Assessment Of Hand Gestures Using Wearable Sensors And Fuzzy Logic, 2019 Santa Clara University
Assessment Of Hand Gestures Using Wearable Sensors And Fuzzy Logic, Angel Cardenas, Ryan Messersmith, Will Newcomb
Bioengineering Senior Theses
Hand dexterity and motor control are critical in our everyday lives because a significant portion of the daily motions we perform are with our hands and require some degree of repetition and skill. Therefore, development of technologies for hand and extremity rehabilitation is a significant area of research that will directly help patients recovering from hand debilities sustained from causes ranging from stroke and Parkinson’s disease to trauma and common injuries. Cyclic activity recognition and assessment is appropriate for hand and extremity rehabilitation because a majority of our essential motions are cyclic in their nature. For a patient on ...
High-Throughput, Portable Microfluidic Aptamer Assay, 2019 Santa Clara University
High-Throughput, Portable Microfluidic Aptamer Assay, Atticus Mccoy, Matthew Curtin
Bioengineering Senior Theses
Aptamer-based assays are a powerful platform for sensing a wide variety of biochemical targets, including drugs, disease biomarker, and biomolecules. However, aptamer assays often lack rapid identification and high-throughput screening. Performing an aptamer-based assay on a microfluidic device is a promising solution to increase throughput, portability, and sensitivity. In this paper, we present a microfluidic device capable of running aptamer-based assays. Our device utilizes normally-closed valves and a central micropump to move fluids throughout the chip. One chip could theoretically be scaled up to run multiple assays, and multiple of these microfluidic devices could be run in parallel to increase ...
Kinematics During Knee Extension, Lunge, And Chair Rise, 2019 University of Denver
Kinematics During Knee Extension, Lunge, And Chair Rise, Center For Orthopaedic Biomechanics, Kevin Shelburne, Phd, Michael D. Harris, Phd, Vasiliki Kefala, Donald R. Hume, Bradley S. Davidson, A. J. Cyr, R. H. Kim, A. A. Ali, E. M. Mannen
Living Kinematics of the Knee
No abstract provided.
Human-Centered Electric Prosthetic (Help) Hand, 2019 Santa Clara University
Human-Centered Electric Prosthetic (Help) Hand, Jamie Ferris, Shiyin Lim, Michael Mehta, Evan Misuraca
Interdisciplinary Design Senior Theses
Through a partnership with Indian non-profit Bhagwan Mahaveer Viklang Sahayata Samiti, we designed a functional, robust, and and low cost electrically powered prosthetic hand that communicates with unilateral, transradial, urban Indian amputees through a biointerface. The device uses compliant tendon actuation, a small linear servo, and a wearable garment outfitted with flex sensors to produce a device that, once placed inside a prosthetic glove, is anthropomorphic in both look and feel. The prosthesis was developed such that future groups can design for manufacturing and distribution in India.
Machine Learning Solution To Organ-At-Risk Segmentation For Radiation Treatment Planning, 2019 Santa Clara University
Machine Learning Solution To Organ-At-Risk Segmentation For Radiation Treatment Planning, Brie Goo, Katrina May, Haobo Zhang, James Olivas
Interdisciplinary Design Senior Theses
In the treatment of cancer using ionizing radiation, it is important to design a treatment plan such that dose to normal, healthy organs is sufficiently low. Today, segmentation requires a trained human to carefully outline, or segment, organs on each slice of a treatment planning computed tomography (CT) scan but it is laborious, time-consuming, and contains intra- and inter-rater variability. Currently, existing clinical automation technology relies on atlas-based automation, which has limited segmentation accuracy. Thus the auto-segmentations require post process editing by an expert. In this paper, we propose a machine learning solution that shortens the segmentation time of organs-at-risk ...
Computational Characterization Of The Cellular Origins Of Electroencephalography, 2019 Marquette University
Computational Characterization Of The Cellular Origins Of Electroencephalography, Shane Hesprich
Master's Theses (2009 -)
Electroencephalography (EEG) is a non-invasive technique used to measure brain activity. Despite its near ubiquitous presence in neuroscience, very little research has gone into connecting the electrical potentials it measures on the scalp to the underlying network activity which generates those signals. This results in most EEG analyses being more macroscopically focused (e.g. coherence and correlation analyses). Despite the many uses of macroscopically focuses analyses, limiting research to only these analyses neglects the insights which can be gained from studying network and microcircuit architecture. The ability to study these things through non-invasive techniques like EEG depends upon the ability ...
Estimating Cognitive Workload In An Interactive Virtual Reality Environment Using Electrophysiological And Kinematic Activity, Christoph Tremmel
Biomedical Engineering Theses & Dissertations
As virtual reality (VR) technology continues to gain prominence in commercial, educational, recreational and research applications, there is increasing interest in incorporating physiological sensors in VR devices for passive user-state monitoring to eventually increase the sense of immersion. By recording physiological signals such as the electroencephalogram (EEG), electromyography (EMG) or kinematic parameters during the use of a VR device, the user’s interactions in the virtual environment could be adapted in real time based on the user’s cognitive state. This dissertation evaluates the feasibility of passively monitoring cognitive workload via electrophysiological and kinematic activity while performing a classical n-back ...
Generation Of Silver Nanoparticle Pharmacokinetic Profiles In A Lung Model, 2019 University of Dayton
Generation Of Silver Nanoparticle Pharmacokinetic Profiles In A Lung Model, Rachel Galaska
Nanomaterial technologies are becoming increasingly prevalent in consumer and industrial applications, including drug delivery, energy harvesting, environmental applications, and medicine due to their unique physiochemical properties. As nanomaterial use increases, so too does human exposure. This has made it progressively more important to understand the toxicological effects of nanomaterials and their interactions with the human body. Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials due to their antibacterial properties. As inhalation is one of the most common exposure routes, understanding the toxicity of these AgNPs on lung tissue was studied. Using A549 cells for a lung tissue ...
Effect Of Activated Carbon On The Performance Of A Solar Thermal Adsorptive Refrigerator (Star) Using Activated Carbon-Ethanol, Joshua Romo
The Solar Thermal Adsorptive Refrigerator (STAR) project at the University of Dayton seeks to bridge sustainability and the need for reliable refrigeration in developing communities. Cost-effective construction, operation, and maintenance as well as the use of a sustainable adsorption pair, activated carbon-ethanol, give STAR great potential in the realm of humanitarian engineering. This project explores the effect of using two activated carbon brands, 8x16 and CocoPlus, on the cyclic performance of the STAR system. Although both brands have similar specifications given by the manufacturer, one (8x16) inhibited successful performance while the other (CocoPlus) enabled it. This project highlights both the ...
Arsenic Remediation Of Maine Drinking Water, 2019 University of Maine
Arsenic Remediation Of Maine Drinking Water, Austin Steward
Arsenic, a metalloid, is one of the most prominent toxins in Maine drinking water. There are approximately 86,500 Maine citizens exposed to water containing arsenic over the maximum contamination level causing adverse effects including nausea, multiple cancers, and a reduction of full scale IQ and executive function. In drinking water, arsenic arises both by the natural leaching from bedrock and from the use of chemicals such as pesticides, embalming fluids, and wood preservatives. Although there are many known arsenic water remediation techniques, finding a method compatible for multiple arsenic isotopes is challenging. In this work, we test the low-energy ...
The Effect Of Defects And Surface Modification On Biomolecular Assembly And Transport, 2019 University of New Mexico - Main Campus
The Effect Of Defects And Surface Modification On Biomolecular Assembly And Transport, Haneen Martinez
Nanoscience and Microsystems ETDs
Nanoscale transport using the kinesin-microtubule (MT) biomolecular system has been successfully used in a wide range of nanotechnological applications including self-assembly, nanofluidic transport, and biosensing. Most of these applications use the ‘gliding motility geometry’, in which surface-adhered kinesin motors attach and propel MT filaments across the surface, a process driven by ATP hydrolysis. It has been demonstrated that active assembly facilitated by these biomolecular motors results in complex, non-equilibrium nanostructures currently unattainable through conventional self-assembly methods. In particular, MTs functionalized with biotin assemble into rings and spools upon introduction of streptavidin and/or streptavidin-coated nanoparticles. Upon closer examination of these ...
Develop A 3d Neurological Disease Model Of Human Cortical Glutamatergic Neurons Using Micropillar-Based Scaffolds, Cheng Chen, Xin Dong, Kai-Heng Fang, Fang Yuan, Yao Hu, Min Xu, Yu Huang, Xixiang Zhang, Danjun Fang, Yan Liu
Biological Engineering Faculty Publications
Establishing an effective three-dimensional (3D) in vitro culture system to better model human neurological diseases is desirable, since the human brain is a 3D structure. Here, we demonstrated the development of a polydimethylsiloxane (PDMS) pillar-based 3D scaffold that mimicked the 3D microenvironment of the brain. We utilized this scaffold for the growth of human cortical glutamatergic neurons that were differentiated from human pluripotent stem cells. In comparison with the 2D culture, we demonstrated that the developed 3D culture promoted the maturation of human cortical glutamatergic neurons by showing significantly more MAP2 and less Ki67 expression. Based on this 3D culture ...
(Poster) Design And Fabrication Of A Custom Wrist Orthosis For Enhanced Patient Comfort, 2019 University of Indianapolis
(Poster) Design And Fabrication Of A Custom Wrist Orthosis For Enhanced Patient Comfort, Marko Tasic, Matthew Hansen, Mang Lian, Demetre Mitchell, Rashedul Sarker, Renny Fernandez, Erin Peterson, Joseph Herzog, David Olawale, Najmus Saqib
ASEE IL-IN Section Conference
This custom wrist orthosis project is the continuation of efforts made by students in the R.B Annis School of Engineering during the 2017-2018 academic year. Throughout this project, we have implemented the Design for Six Sigma (DFSS) methodology to guide the design process. Within the R.B. Annis School of Engineering, this methodology has been adapted into guide the DesignSpine process. We have designed a new orthosis that is custom fabricated for enhanced patient comfort. In the occupational therapy field, patients have reportedly not been wearing their prescribed orthoses/braces, which are designed to stabilize injured areas so that ...
Identification Of New Glutamate Decarboxylases From Streptomyces For Efficient Production Of Γ-Aminobutyric Acid In Engineered Escherichia Coli, Haina Yuan, Hongbo Wang, Ozkan Fidan, Yong Qin, Gongnian Xiao, Jixun Zhan
Biological Engineering Faculty Publications
Gamma (γ)-Aminobutyric acid (GABA) as a bioactive compound is used extensively in functional foods, pharmaceuticals and agro-industry. It can be biosynthesized via decarboxylation of monosodium glutamate (MSG) or L-glutamic acid (L-Glu) by glutamate decarboxylase (GAD; EC188.8.131.52). GADs have been identified from a variety of microbial sources, such as Escherichia coli and lactic acid bacteria. However, no GADs from Streptomyces have been characterized. The present study is aimed to identify new GADs from Streptomyces strains and establish an efficient bioproduction platform for GABA in E. coli using these enzymes.
By sequencing and analyzing the genomes ...
Assessing Data Management Support Needs Of Bioengineering And Biomedical Research Faculty, 2019 University of Illinois at Urbana-Champaign
Assessing Data Management Support Needs Of Bioengineering And Biomedical Research Faculty, Christie A. Wiley, Margaret H. Burnette
Journal of eScience Librarianship
Objectives: This study explores data management knowledge, attitudes, and practices of bioengineering and biomedical researchers in the context of the National Institutes of Health-funded research projects. Specifically, this study seeks to answer the following questions:
- What is the nature of biomedical and bioengineering research on the Illinois campus and what kinds of data are being generated?
- To what degree are biomedical and bioengineering researchers aware of best practices for data management and what are the actual data management behaviors?
- What aspects of data management present the greatest challenges and frustrations?
- To what degree are biomedical and bioengineering researchers aware of ...
Characterizing Short-Wave Infrared Fluorescence Of Conventional Near-Infrared Fluorophores, 2019 Dartmouth College
Characterizing Short-Wave Infrared Fluorescence Of Conventional Near-Infrared Fluorophores, Brook K. Byrd, Margaret R. Folaron, Joseph P. Leonor, Rendall R. Strawbridge, Xu Cao, Petr Bruza, Scott C. Davis
Open Dartmouth: Faculty Open Access Scholarship
The observed behavior of short-wave infrared (SWIR) light in tissue, characterized by relatively low scatter and subdiffuse photon transport, has generated considerable interest for the potential of SWIR imaging to produce high-resolution, subsurface images of fluorescence activity in vivo. These properties have important implications for fluorescence-guided surgery and preclinical biomedical research. Until recently, translational efforts have been impeded by the conventional understanding that fluorescence molecular imaging in the SWIR regime requires custom molecular probes that do not yet have proven safety profiles in humans. However, recent studies have shown that two readily available near-infrared (NIR-I) fluorophores produce measurable SWIR fluorescence ...
Improving Wastewater Treatment Using Algal Biofilms And Bioenergy, 2019 Utah State University
Improving Wastewater Treatment Using Algal Biofilms And Bioenergy, Nathan Guymon
Research on Capitol Hill
This project represents a collaboration between Utah State University, Central Valley Water Reclamation Facility (CVWRF), and WesTech Engineering, Inc. The goal of the project is to help water treatment plants meet state nutrient standards and reduce operating costs. This is being accomplished in three major sections:
1. Wastewater treatment – microalgae is grown to remove nitrogen and phosphorus from water.
2. Biogas generation – the microalgae is harvested and processed to produce methane gas used to generate power.
3. Fertilizer production – nutrients are also collected from the wastewater and turned into high-value fertilizer.
By creating systems that remove nutrients from water and ...
Increasing Stem Literacy Through Directed Outreach, 2019 Purdue University
Increasing Stem Literacy Through Directed Outreach, Liesl Krause, Nicole Vike, Yukai Zou, Jana Vincent
Engagement & Service-Learning Summit: Connecting Through Listening & Scholarship
5th Annual Engagement and Service-Learning Summit: Connecting Through Listening and Scholarship, Thursday February 28th, 2019, Hosted by the Office of Engagement and Purdue Honors College
Developing And Testing Of An Upper Limb Exoskeleton For Stroke Patients, 2019 University of Nebraska at Omaha
Developing And Testing Of An Upper Limb Exoskeleton For Stroke Patients, Drew Dudley, David Salazar
Student Research and Creative Activity Fair
Objective: The main objective of this study was to determine functional and neuromuscular outcomes of stroke patients using their non-preferred hand with and without a 3D printed passive exoskeleton compared to controls using their non-preferred hand with and without the passive exoskeleton. Methods: Adults at least six months post stroke (Stroke, n = 5) and age- and sex- matched healthy controls (Control, n = 5) performed nine trials of a gross motor task while having their brain activity measured. The Fugl-Meyer and “Box and Block” test was used to measure the gross dexterity of the subjects with and without the exoskeleton. Strength ...
Determining The Relationship Between Walking Activity And Inter-Day Patterns In Stroke Survivors, 2019 University of Nebraska at Omaha
Determining The Relationship Between Walking Activity And Inter-Day Patterns In Stroke Survivors, Sydney Andreasen
Student Research and Creative Activity Fair
Populations that have suffered from stroke are generally less active than people of otherwise similar demographics and are more susceptible to further health problems, such as another stroke. This study seeks to assess the validity of a treatment that encourages stroke survivors to walk more steps each day, in order to improve their active abilities and become less idle by establishing motivation for activity and therefore, also establishing patterns in the distribution of that activity throughout a stroke survivor’s day. 172 subjects (6 months post-stroke) have participated in a step activity monitoring program to record steps taken using wearable ...