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Designing Silk Protein-Based Composite Materials With Tunable Heat Transfer And Magnetic Properties, Ye Xue 2020 Rowan University

Designing Silk Protein-Based Composite Materials With Tunable Heat Transfer And Magnetic Properties, Ye Xue

Theses and Dissertations

Renewable and biocompatible silk protein materials with desired physical properties show promising applications in biomedical field. In this work, a set of protein-based composites with desired thermal and magnetic properties, enhanced by the appropriate distribution of nanofillers in the protein matrix in both 2D-film and 1D-fiber forms was investigated. Results indicate that secondary structures of silk protein materials regenerated by a formic acid-calcium chloride method are different from those of their respective natural silk fibers. Intramolecular beta-sheet structures were found to dominate these silk films, causing these regenerated samples to be water-insoluble but more flexible than traditional silk films with ...


3d Culture Strategies For The Dynamic Expansion And Preconditioning Of Adipose-Derived Stromal Cells On Decellularized Adipose Tissue Bioscaffolds, Tim Tian Han 2020 The University of Western Ontario

3d Culture Strategies For The Dynamic Expansion And Preconditioning Of Adipose-Derived Stromal Cells On Decellularized Adipose Tissue Bioscaffolds, Tim Tian Han

Electronic Thesis and Dissertation Repository

Adipose tissue engineering holds promise for the development of therapeutic strategies for subcutaneous adipose tissue regeneration to treat defects resulting from congenital birth defects, invasive surgical procedures and traumatic injuries. Decellularized adipose tissue (DAT) scaffolds represent a potential off-the-shelf tissue substitute for volume augmentation. Seeding the DAT with adipose-derived stromal cells (ASCs) has been shown to enhance adipose tissue regeneration in immunocompetent animals in vivo. Although promising, this strategy is limited by low cell attachment on the DAT. As such, this thesis focused on the development of bioreactor strategies to enhance the capacity of human ASCs to stimulate angiogenesis and ...


Effects Of Hard-To-Soft Segment Ratios On The Synthesis And Physico-Mechanical Properties Of Polyurethane Films, Aaron C. Wilson 2020 University of Texas at Tyler

Effects Of Hard-To-Soft Segment Ratios On The Synthesis And Physico-Mechanical Properties Of Polyurethane Films, Aaron C. Wilson

Mechanical Engineering Theses

Blood-contacting cardiovascular stents often induce a secondary clotting event due to unrestricted enzymatic activities. The use of hemocompatible polyurethane coatings on these implantable devices is one of the most promising methods to reduce device rejection. In this study, four commercial polyurethane films of various thicknesses and compositions were evaluated for their anticoagulation properties. Results suggested that these films exhibited excellent thermal and physico-mechanical properties while capable of increasing contact time with blood plasma by over a thousand-fold as compared to a control surface. Due to the unknown structure and composition of these commercial films, polyurethane samples were synthesized from toluene ...


Design Of A 3d Printed Bioreactor For Bone Cancer Research, Brooklyn K. VanDerWolde, Katelyn Hillson 2020 South Dakota State University

Design Of A 3d Printed Bioreactor For Bone Cancer Research, Brooklyn K. Vanderwolde, Katelyn Hillson

The Journal of Undergraduate Research

Bone cancer is an aggressive disease and has peak occurrence during physiological stimulation of growth and aging. Astronauts who undergo long-term space missions also acquire an increased risk of bone tissue degeneration and cancer. Few in-vitro models currently exist capable of reproducing the complex microenvironment of bone tissue to support multicellular activity in a three-dimensional structure. This limits the ability to understand disease progression and develop suitable treatment strategies. Therefore, developing a bone tissue model and an associated bioreactor is critical to understand the risks associated with cancer progression and improve treatment and preventions related to those risks. The goal ...


Characterization Of Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes During Ultrafiltration And Hemodialysis, Kristyn Robling 2020 University of Arkansas, Fayetteville

Characterization Of Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes During Ultrafiltration And Hemodialysis, Kristyn Robling

Biomedical Engineering Undergraduate Honors Theses

The ninth leading cause of death in the United States is kidney disease, and hemodialysis is the process most commonly prescribed for treatment. It utilizes a selectively permeable membrane filter to remove toxins such as urea from the blood and retain necessary protein levels. However, traditional filters, such as cellulose triacetate, used during dialysis can be inefficient in terms of separation performance and reduction of fouling. Recent exploration of nanoparticles has resulted in the creation of Oxone Mediated TEMPO-Oxidized Nano Cellulose which has properties that are believed to increase hydrophilicity, increase tensile capacity, decrease membrane resistance and lower fouling, making ...


Analysis Of Blood Purification Studies On Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes, Tony Roller 2020 University of Arkansas, Fayetteville

Analysis Of Blood Purification Studies On Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes, Tony Roller

Biomedical Engineering Undergraduate Honors Theses

End-stage renal disease (ESRD) is currently the ninth leading cause of death in the United States, and of the 661,00 Americans diagnosed with ESRD, approximately 468,800 were on hemodialysis in 2016. Hemodialysis refers to a technique where a machine combined with a membrane, often referred to as an artificial kidney, is used to clean blood by removing any waste such as urea, potassium, and other smaller waste products while preserving the concentrations and integrity of cells and proteins in the blood. It has been shown in artificial blood studies that cellulose nanomaterials, like TEMPO/Oxidized cellulose nanoparticles (TOCNs ...


Emergency Eye Simulation Model, Gavin L. Warrington, Christopher Forsyth, Lexus Morris, Natalie Ledezma 2020 University of Tennessee, Knoxville

Emergency Eye Simulation Model, Gavin L. Warrington, Christopher Forsyth, Lexus Morris, Natalie Ledezma

Chancellor’s Honors Program Projects

No abstract provided.


Modified Stent Design For A Coronary Bifurcation Lesion, Abigail Nowell 2020 University of Arkansas, Fayetteville

Modified Stent Design For A Coronary Bifurcation Lesion, Abigail Nowell

Biological Sciences Undergraduate Honors Theses

Currently, 18.2 million adults aged 20 and older are diagnosed with Coronary Artery Disease (CAD) (Benjamin et al., 2019). Stenosis is the most common intervention. However, when a patient has a bifurcated artery, treatment becomes more difficult and is often unsuccessful. This project created a new stent and balloon complex that was tested in vitro using a gel phantom artery model. Two separate prototypes have been created and tested so far, with improvements made upon each. Testing is still underway with Prototype 2.


Design Of An Affordable Rotating Drum Electrospinner For Classroom Education, Peder Solberg 2020 South Dakota State University

Design Of An Affordable Rotating Drum Electrospinner For Classroom Education, Peder Solberg

The Journal of Undergraduate Research

Electrospinning is a technology used to generate small fibers down to nano-scale size. This method of fiber creation has been around for many years. However, in recent years electrospinning has found increased applications, especially in the area of tissue engineering due to its ability to create fibers with properties similar to the extracellular matrix in tissue. An electrospinning platform can illustrate concepts of engineering, electro-mechanical system design, manufacturing, and biomedical applications in one single package. Hence, it provides an excellent opportunity to integrate into secondary (middle and high school) and post-secondary (undergraduate) technology education.

Furthermore, just as integration of 3D ...


Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso 2020 California Polytechnic State University, San Luis Obispo

Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso

Biomedical Engineering

The purpose of this scope of work is to highlight the progress and development of SoloStand sponsored by Derek Herrera, chief technical officer and founder of SpinalSingularity. SoloStand is an attachment to a wheelchair that will benefit paraplegics that use wheelchairs. A portable and customizable attachment to a wheelchair will allow the user to do everyday tasks without transferring into a separate standing wheelchair and travel more easily. This document outlines everything that has been done in fulfillment of our senior project requirements.


Role Of Nanoparticle–Polymer Interactions On The Development Of Double-Network Hydrogel Nanocomposites With High Mechanical Strength, Andrew Chang, Nasim Babhadiashar, Emma Barrett-Catton, Prashanth Asuri 2020 Santa Clara University

Role Of Nanoparticle–Polymer Interactions On The Development Of Double-Network Hydrogel Nanocomposites With High Mechanical Strength, Andrew Chang, Nasim Babhadiashar, Emma Barrett-Catton, Prashanth Asuri

Bioengineering

Extensive experimental and theoretical research over the past several decades has pursued strategies to develop hydrogels with high mechanical strength. Our study investigated the effect of combining two approaches, addition of nanoparticles and crosslinking two different polymers (to create double-network hydrogels), on the mechanical properties of hydrogels. Our experimental analyses revealed that these orthogonal approaches may be combined to synthesize hydrogel composites with enhanced mechanical properties. However, the enhancement in double network hydrogel elastic modulus due to incorporation of nanoparticles is limited by the ability of the nanoparticles to strongly interact with the polymers in the network. Moreover, double-network hydrogel ...


Bubble Lab Exercise, Peter Beltramo 2020 University of Massachusetts Amherst

Bubble Lab Exercise, Peter Beltramo

Science and Engineering Saturday Seminars

The cell membrane is a ubiquitous component in mammalian cells which control many vital biological functions. It consists of a phospholipid bilayer with embedded protein molecules which serve to transport molecules between the interior and exterior of the cell. Understanding what makes cell membranes so important and how they function requires concepts from physics, chemistry, and of course biology, but it is difficult to learn and conceptualize the structure and function of membranes due to their nanoscopic size and dynamic nature which can’t be properly appreciated in a static textbook. This activity draws analogies between the chemistry and structure ...


Gravity-Drawing Flexible Silicone Filaments As Fiber Optics And Model Foldamers, Katherine Snell 2020 Claremont Colleges

Gravity-Drawing Flexible Silicone Filaments As Fiber Optics And Model Foldamers, Katherine Snell

CMC Senior Theses

Here, we present a method of gravity-drawing polydimethylsiloxane (PDMS) silicone fibers with application as fiber optics and as model foldamers. Beginning as a viscous liquid, PDMS is cured using heat until its measured viscosity reaches 4000 mPa•s. The semi-cured elastomer is then extruded through a tube furnace to produce thin (diameters on the order of hundred micrometers) filaments with scalable lengths. PDMS is biocompatible, gas-permeable, flexible, and hydrophobic. Additionally, the PDMS surface hydrophobicity can be modified via UV exposure, O2 plasma, and corona discharge. We demonstrate the patternibility (i.e patterns of hydrophobicity) of PDMS fibers, adding complexity to ...


Binder Saturation, Layer Thickness, Drying Time And Their Effects On Dimensional Tolerance And Density Of Cobalt Chrome - Tricalcium Phosphate Biocomposite, John Ruprecht 2020 Minnesota State University, Mankato

Binder Saturation, Layer Thickness, Drying Time And Their Effects On Dimensional Tolerance And Density Of Cobalt Chrome - Tricalcium Phosphate Biocomposite, John Ruprecht

All Graduate Theses, Dissertations, and Other Capstone Projects

Traditional metals such as stainless steel, titanium and cobalt chrome are used in biomedical applications (implants, scaffolds, etc.) but suffer from issues such as osseointegration and compatibility with existing bone. One way to improve traditional biomaterials is to incorporate ceramics with these metals so that their mechanical properties can be similar to cortical bones. Tricalcium phosphate is such a ceramic with properties such that it can be used in the human body. This research explores the use of the Binder Jetting based additive manufacturing process to create a novel biocomposite made of cobalt chrome and tricalcium phosphate. Experiments were conducted ...


Micrococcal-Nuclease-Triggered On-Demand Release Of Vancomycin From Intramedullary Implant Coating Eradicates Staphylococcus Aureus Infection In Mouse Femoral Canals, Ananta Ghimire, Jordan D. Skelly, Jie Song 2019 University of Massachusetts Medical School

Micrococcal-Nuclease-Triggered On-Demand Release Of Vancomycin From Intramedullary Implant Coating Eradicates Staphylococcus Aureus Infection In Mouse Femoral Canals, Ananta Ghimire, Jordan D. Skelly, Jie Song

Orthopedics and Physical Rehabilitation Publications

Preventing orthopedic implant-associated bacterial infections remains a critical challenge. Current practices of physically blending high-dose antibiotics with bone cements is known for cytotoxicity while covalently tethering antibiotics to implant surfaces is ineffective in eradicating bacteria from the periprosthetic tissue environment due to the short-range bactericidal actions, which are limited to the implant surface. Here, we covalently functionalize poly(ethylene glycol) dimethacrylate hydrogel coatings with vancomycin via an oligonucleotide linker sensitive to Staphylococcus aureus (S. aureus) micrococcal nuclease (MN) (PEGDMA-Oligo-Vanco). This design enables the timely release of vancomycin in the presence of S. aureus to kill the bacteria both on the ...


Liver Cancer: Current And Future Trends Using Biomaterials, Sue Anne Chew, Stefania Moscato, Sachin George, Bahareh Azimi, Serena Danti 2019 The University of Texas Rio Grande Valley

Liver Cancer: Current And Future Trends Using Biomaterials, Sue Anne Chew, Stefania Moscato, Sachin George, Bahareh Azimi, Serena Danti

Health and Biomedical Sciences Faculty Publications and Presentations

Hepatocellular carcinoma (HCC) is the fifth most common type of cancer diagnosed and the second leading cause of death worldwide. Despite advancement in current treatments for HCC, the prognosis for this cancer is still unfavorable. This comprehensive review article focuses on all the current technology that applies biomaterials to treat and study liver cancer, thus showing the versatility of biomaterials to be used as smart tools in this complex pathologic scenario. Specifically, after introducing the liver anatomy and pathology by focusing on the available treatments for HCC, this review summarizes the current biomaterial-based approaches for systemic delivery and implantable tools ...


The Co-Delivery Of Syngeneic Adipose-Derived Stromal Cells And Macrophages On Decellularized Adipose Tissue Bioscaffolds For In Vivo Soft Tissue Regeneration, Hisham A. Kamoun 2019 The University of Western Ontario

The Co-Delivery Of Syngeneic Adipose-Derived Stromal Cells And Macrophages On Decellularized Adipose Tissue Bioscaffolds For In Vivo Soft Tissue Regeneration, Hisham A. Kamoun

Electronic Thesis and Dissertation Repository

Decellularized adipose tissue (DAT) bioscaffolds are a promising platform for the delivery of pro-regenerative cell populations with the goal of promoting adipose tissue regeneration. The current study investigated the effects of seeding DAT bioscaffolds with syngeneic bone marrow-derived macrophages and/or adipose-derived stromal cells (ASCs) on in vivo soft tissue regeneration. Methods were established to derive the macrophages from MacGreen mice, which were dynamically seeded onto the DAT scaffolds alone or in combination with ASCs. Seeded and unseeded scaffolds were implanted subcutaneously into C57Bl/6 mice. At 2 and 4 weeks, cell infiltration, angiogenesis, and adipogenesis were analyzed through histology ...


Cdse Quantum Dots Synthesis Laboratory Course For High School Students, Danlin Zuo, Gyuseok Kim, David Jones 2019 Singh Center for Nanotechnology

Cdse Quantum Dots Synthesis Laboratory Course For High School Students, Danlin Zuo, Gyuseok Kim, David Jones

Protocols and Reports

Cadmium selenide quantum dot is a fascinating subject for leading high school students to the quantum world. An 8-hour laboratory course for up to 12 high school students is proposed. The 8-hour course consist of two 4-hours sections. This laboratory course includes the quantum dot syntheses, absorption and emission characterization, and data analysis. The proposes process runs at relatively lower temperature which means safe and easy, and shows apparent experimental results.


Spark Plasma Sintering Of Low Modulus Titanium-Niobium-Tantalum-Zirconium (Tntz) Alloy For Biomedical Applications, Nicholas Mavros, Taban Larimian, Javier Esqivel, Rajeev Kumar Gupta, Rodrigo Contieri, Tushar Borkar 2019 Cleveland State University

Spark Plasma Sintering Of Low Modulus Titanium-Niobium-Tantalum-Zirconium (Tntz) Alloy For Biomedical Applications, Nicholas Mavros, Taban Larimian, Javier Esqivel, Rajeev Kumar Gupta, Rodrigo Contieri, Tushar Borkar

Mechanical Engineering Faculty Publications

In metallurgy, titanium has been a staple for biomedical purposes. Its slow toxicity and alloying versatility make it an attractive choice for medical applications. However, studies have shown the difference in elastic modulus between titanium alloys (116 GPa) and human bone (10–40 GPa), which contributes to long term issues with loose hardware fixation. Additionally, long term studies have shown elements such as vanadium and aluminum, which are commonly used in Ti-6Al-4V biomedical alloys, have been linked to neurodegenerative diseases like Alzheimer and Parkinson. Alternative metals known to be less toxic are being explored as replacements for alloying elements in ...


Comparison Of Artifacts Between Paste And Collodion Method Of Electrode Application In Pediatric Eeg, Danielle Brigham, Yash Shah, Kanwaljit Singh, Ivan Pavkovic, Shefali Karkare, Sanjeev V. Kothare 2019 Cohen Children's Medical Center

Comparison Of Artifacts Between Paste And Collodion Method Of Electrode Application In Pediatric Eeg, Danielle Brigham, Yash Shah, Kanwaljit Singh, Ivan Pavkovic, Shefali Karkare, Sanjeev V. Kothare

Open Access Articles

Objectives: Children pose challenges to obtain quality EEG data due to excessive artifact. Collodion is used in EEG electrodes due to its water resistance and strong adhesive qualities. This study was done to evaluate differences in artifacts between the collodion and paste method.

Methods: 115 subjects (children age > 3 years) were randomized into paste and collodion groups and artifacts evaluated at baseline and every hour over 30s increments. Age, sleep state, and number of electrodes with artifact were also documented. T-test was performed to determine differences in the various parameters between the two groups.

Results: 61 subjects were in the ...


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