Matrix Metalloproteinase-14 Is A Mechanically Regulated Activator Of Secreted Mmps And Invasion, 2018 Iowa State University
Matrix Metalloproteinase-14 Is A Mechanically Regulated Activator Of Secreted Mmps And Invasion, Amanda Haage, Dong Hyun Nam, Xin Ge, Ian C. Schneider
Ian C. Schneider
Matrix metalloproteinases (MMPs) are extracellular matrix (ECM) degrading enzymes and have complex and specific regulation networks. This includes activation interactions, where one MMP family member activates another. ECM degradation and MMP activation can be initiated by several different stimuli including changes in ECM mechanical properties or intracellular contractility. These mechanical stimuli are known enhancers of metastatic potential. MMP-14 facilitates local ECM degradation and is well known as a major mediator of cell migration, angiogenesis and invasion. Recently, function blocking antibodies have been developed to specifically block MMP-14, providing a useful tool for research as well as therapeutic applications. Here we ...
Exploiting Click-Chemistry And Microfluidics To Map The Neuronal Itinerary Of App Processing And Amyloid-Beta Generation, 2017 Washington University in St. Louis
Exploiting Click-Chemistry And Microfluidics To Map The Neuronal Itinerary Of App Processing And Amyloid-Beta Generation, Namratha Srinivas
Engineering and Applied Science Theses & Dissertations
Alzheimer’s disease (AD) is a chronic neurodegenerative disease and is the sixth leading cause of death in the United States with approximately 5.5 million Americans diagnosed with it. The neuropathological hallmark includes extracellular senile plaques and intraneuronal neurofibrillary tangles. Recent GWAS studies have identified genes associated with AD, and have revealed several classes of genes implicated in disease pathogenesis. In particular, three general pathways associated with an increased risk of AD included: 1) cholesterol metabolism, innate immune system, and the membrane trafficking. Our lab has focused on intracellular trafficking as it relates to the processing of amyloid precursor ...
Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, 2017 The Universty of Western Ontario
Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, Ahmed El Ruby Abdel Rahman Mohamed
Electronic Thesis and Dissertation Repository
The fast diminishing of fossil fuels in the near future, as well as the global warming caused by increasing greenhouse gases have motivated the urgent quest to develop advanced materials as cost-effective photoanodes for solar light harvesting and many other photocatalytic applications. Recently, titania nanotube arrays (TNTAs) fabricated by anodization process has attracted great interest due to their excellent properties such as: high surface area, vertically oriented, highly organized, one-dimensional, nanotubular structure, photoactivity, chemical stability and biocompatibility. This unique combination of excellent properties makes TNTAs an excellent photoanode for solar light harvesting. However, the relatively wide band gap energy of ...
Study The Flexural Properties And Maxmium Shear Stree.Pdf, 2017 University of Technology - Iraq
Study The Flexural Properties And Maxmium Shear Stree.Pdf, Jawad K. Oleiwi, Sihama I. Salih
Jawad K. Oleiwi
An Electrochemical Analysis Of Fretting Corrosion In Metal-On-Metal Hip Implants Subjected To High Impaction Loads, Joe Morin, Timothy L. Norman, Thomas K. Fehring
Timothy L. Norman, Ph.D.
The metal-on-metal total hip arthroplasty, a procedure where the hip joint is replaced by a femoral prosthesis with a metal femoral head and a metal socket, has been a popular option for patients requiring a hip joint replacement. Metal on metal hip implants have been a successful implant design until recently where there has been an increased number of failures of this type of implant due to fretting corrosion, believed to be caused from the use of large femoral heads. Fretting corrosion in hip implants results from cyclic micromotion at the taper-trunnion interface; this interface motion removes the protective oxidation ...
Development Of Starch-Polyvinyl Alcohol (Pva) Biodegradable Film: Effect Of Cross-Linking Agent And Antimicrobials On Film Characteristics, 2017 Agricultural and Food Engineering Department, Indian Institute of Technology, Kharagpur
Development Of Starch-Polyvinyl Alcohol (Pva) Biodegradable Film: Effect Of Cross-Linking Agent And Antimicrobials On Film Characteristics, Aniket Satish More, Chandani Sen, Madhusweta Das
Journal of Applied Packaging Research
To satisfy the need of developing eco-friendly flexible antimicrobial packaging film with minimum use of synthetic chemical ingredients, the present study examined the efficacy of citric acid (CA) as cross-linking agent and essential oils (EOs), viz., cinnamon essential oil (CEO) and oregano essential oil (OEO) as natural antimicrobials in corn starch-polyvinyl alcohol (CS-PVA) film. Compared to film prepared from filmogenic solution (FS) containing 75 kg CS+8.75 kg PVA+24.6 kg glycerol per m3 FS, film additionally containing CA at 0.07 kg/kg CS indicated 95% higher ultimate tensile strength (UTS) and 27% lower water vapor ...
A Graphene-Based Flexible Pressure Sensor With Applications To Plantar Pressure Measurement And Gait Analysis, Cunguang Lou, Shuo Wang, Tie Liang, Chenyao Pang, Lei Huang, Mingtao Run, Xiuling Liu
Open Access Articles
In the present study, we propose and develop a flexible pressure sensor based on the piezoresistive effect of multilayer graphene films on polyester textile. The pressure response results from the deformation of graphene conductive network structure and the changes in resistance. Here, we show that the graphene pressure sensor can achieve a sensitivity value of 0.012 kPa - 1 , the measurement range can be as high as 800 kPa, and the response time can reach to 50 ms. Subsequently, a stable in-shoe wireless plantar pressure measurement system is developed and dynamic pressure distribution is acquired in real-time. Overall, the graphene ...
Identifying And Reducing Variability, Improving Scaffold Morphology, And Investigating Alternative Materials For The Blood Vessel Mimic Lab Electrospinning Process, 2017 California Polytechnic State University, San Luis Obispo
Identifying And Reducing Variability, Improving Scaffold Morphology, And Investigating Alternative Materials For The Blood Vessel Mimic Lab Electrospinning Process, Evan M. Dowey
Master's Theses and Project Reports
The work of the Cal Poly Tissue Engineering Lab is primarily focused on the fabrication, characterization, and improvement of “Blood Vessel Mimics” (BVMs), tissue engineered constructs used to evaluate cellular response to vascular medical devices. Currently, cells are grown onto fibrous, porous tubes made using an in-house electrospinning process from PLGA, a biocompatible co-polymer. The adhesion and proliferation of cells in a BVM is reliant on the micro-scale structure of the PLGA scaffold, and as such it is of great importance for the electrospinning process to consistently produce scaffolds of similar morphologies. Additionally, it has been shown that cell proliferation ...
Effect Of Siwak And Bamboo Fibers On Tensile Properties Of Self-Cure.Pdf, 2017 University of Technology - Iraq
Effect Of Siwak And Bamboo Fibers On Tensile Properties Of Self-Cure.Pdf, Jawad K. Oleiwi, Sihama I. Salih
Jawad K. Oleiwi
Rice Hull Bioreactor For Recirculating Aquaculture, 2017 Louisiana State University and Agricultural and Mechanical College
Rice Hull Bioreactor For Recirculating Aquaculture, Marlon A. Greensword
LSU Doctoral Dissertations
The engineering of floating media biofilters has been optimized over the years. The backwashing process has made them more energy and water efficient. Likewise, moving bed bioreactors (MBBR) are gaining interest and popularity because they are relatively affordable to build. Yet, developing countries’ aquaculture production remains largely excluded from the advances made in recirculating aquaculture systems (RAS). This discrepancy is partially driven by the high costs of media such plastic beads and Kaldnes (KMT) media, commonly used in MBBR.
This dissertation evaluates the usability and profitability of rice hulls (RH), an abundant by-product in many developing nations, as a sinking ...
How Strongly Do Oysters Stick?, 2017 Universidad de Los Andes - Colombia
How Strongly Do Oysters Stick?, Nicolás M. Morato, Andrés M. Tibabuzo, Jonathan J. Wilker
The Summer Undergraduate Research Fellowship (SURF) Symposium
Biological adhesives are a type of interfacial material that has incredible potential to generate new biomimetic compounds that can replace current strong, but toxic, adhesives. Therefore, a study of the chemical composition and mechanical properties of those bio-adhesives is necessary. However, in the case of oysters, despite known chemical characterization of the adult’s adhesive, there are almost no studies on its mechanical properties. Furthermore, there is no available information on the adhesive properties of spat (oysters in their larvae state). Herein, we present the first mechanical characterization of the spat adhesive, measuring its adhesion strength by hydrodynamic determination using ...
Preparation And Investigation Of Some Properties Of.Pdf, 2017 University of Technology - Iraq
Preparation And Investigation Of Some Properties Of.Pdf, Jawad K. Oleiwi
Jawad K. Oleiwi
Hydrodynamic Assessment Of A Porcine Small Intestinal Sub-Mucosa Bioscaffold Valve For Pediatric Mitral Valve Replacement, 2017 Florida International University
Hydrodynamic Assessment Of A Porcine Small Intestinal Sub-Mucosa Bioscaffold Valve For Pediatric Mitral Valve Replacement, Omkar V. Mankame
FIU Electronic Theses and Dissertations
Valve replacement for critical heart valve diseases is in many cases not an option. Our clinical experience in pediatric compassionate care has shown robust function of porcine small intestinal submucosa (PSIS) valves. We assessed functional effectiveness of 4ply (~320µm) and 2ply (~166µm) PSIS mitral valves under pediatric-relevant hemodynamic pulsatile conditions. Key conclusions: (i)PSIS valves demonstrated statistically similar acute functionality in comparison to a commercially available valve. (ii)Energy losses were similar (p>0.05) under pediatric conditions which was not the case under adult aortic conditions. (iii)2ply valves were observed to be superior to 4ply, based on the ...
A Wood-Powered Lawn Mower: Separating The Rules Of Thumb From Engineering Design, 2017 Western Kentucky University
A Wood-Powered Lawn Mower: Separating The Rules Of Thumb From Engineering Design, William White
Honors College Capstone Experience/Thesis Projects
Biomass gasification, the thermal process of exracting combustible gasses from organic matter, is an established procedure that has been used for many years to provide fuel in various applications. It is a potential source of renewable fuel and has proven useful as a crisis energy source. This thesis investigates the primary engineering science principles involved in gasifier-engine system design. It arises from and supplements a WKU mechanical engineering senior project. The senior project has developed a wood gasification system designed to power a riding lawn mower. The thesis reiews theory-based design and separates it from informal hit and miss approaches ...
A Method To Quantify Mixing In A Two Component Fluidized Bed, 2017 Iowa State University
A Method To Quantify Mixing In A Two Component Fluidized Bed, Norman K. Keller, Theodore J. Heindel
Theodore J. Heindel
Fluidized bed technology can be used for pyrolysis and gasification of solid fuel particles such as biomass, which is important to industry because of its potential as an alternative for petroleum-based fuels. To efficiently utilize a fluidized bed reactor it is necessary, among other factors, to investigate the mixing and segregation behavior of the fuel particles with the bed material. In order to characterize the material distribution, a technique to visualize the biomass inside a fluidized bed reactor has been developed using X-ray computed tomography (CT) scans. This paper presents an image analysis procedure that can be used to quantify ...
Rapid Cell Extraction In Aqueous Two-Phase Microdroplet Systems, 2017 Imperial College London
Rapid Cell Extraction In Aqueous Two-Phase Microdroplet Systems, Kalpana Vijayakumar, Shelly Gulati, Andrew J. De Mello, Joshua B. Edel
Distinguishing specific cells is an essential technique in cell research and clinical diagnostics. We report a novel method to passively isolate and extract cells in a microfluidic device. We utilise a droplet-based microfluidic system to generate an aqueous two phase system in which aqueous droplets consist of two phases in the form of a double emulsion. Specifically, we generate PEG droplets that completely encapsulate DEX droplets within a microfluidic channel. Target cells can be introduced directly into the droplets and driven to partition to the more favourable phase, whilst still being contained within the aqueous droplet. Human T lymphoma cells ...
A Tunable, Three-Dimensional In Vitro Culture Model Of Growth Plate Cartilage Using Alginate Hydrogel Scaffolds, 2017 University of Nebraska Medical Center
A Tunable, Three-Dimensional In Vitro Culture Model Of Growth Plate Cartilage Using Alginate Hydrogel Scaffolds, Alek G. Erickson, Taylor D. Laughlin, Sarah Romereim, Catherine Sargus-Patino, Angela K. Pannier, Andrew T. Dudley
Biological Systems Engineering: Papers and Publications
Defining the final size and geometry of engineered tissues through precise control of the scalar and vector components of tissue growth is a necessary benchmark for regenerative medicine, but it has proved to be a significant challenge for tissue engineers. The growth plate cartilage that promotes elongation of the long bones is a good model system for studying morphogenetic mechanisms because cartilage is composed of a single cell type, the chondrocyte; chondrocytes are readily maintained in culture; and growth trajectory is predominately in a single vector. In this cartilage, growth is generated via a differentiation program that is spatially and ...
Optimizing Microfluidic Design For Cell Separation, 2017 University of Massachusetts Lowell
Optimizing Microfluidic Design For Cell Separation, Joseph Wakim, Marisel De Jesus Vega, Nese Orbey, Carol Barry
UMass Center for Clinical and Translational Science Research Retreat
To evaluate the performance of various designs of crossflow filtration microfluidic devices, blood flow was modeled using computational fluid dynamics software (COMSOL Multiphysics). Velocity profiles were generated and used to analyze four critical design parameters: pillar size, pillar shape, gap size, and wall length. These parameters were optimized to yield greatest flow from an unfiltered main channel into two filtered side channels of the device, thereby maximizing filtration capacity.
Devices containing pillars of 10 µm diameter yielded a significantly greater filtration capacity than devices with pillars of 20 µm diameter. Flow patterns from the main channel to the side channels ...
Pulse Oximetry, 2017 Worcester Polytechnic Institute
Pulse Oximetry, Yitzhak Mendelson
UMass Center for Clinical and Translational Science Research Retreat
As part of the mini-symposium entitled "Bench to Bedside: Engineering Technology Translation," Dr. Mendelson describes pulse oximetry technology and how that technology idea successfully developed into a real world medical product.
Design And Validation Of Delivery Systems For Galectin-3 For Skin Healing Applications, 2017 The University of Western Ontario
Design And Validation Of Delivery Systems For Galectin-3 For Skin Healing Applications, Karrington A. Mcleod
Electronic Thesis and Dissertation Repository
Chronic wounds present a significant burden to patients, causing pain, impairing limb function, and often resulting in the need for amputation. Treatment of chronic dermal wounds is challenging, with current therapies showing limited efficacy in clinical trials. As galectin-3 has been implicated in several wound healing processes, its efficacy as a therapeutic in skin healing was investigated in this study. An electrospun gelatin scaffold loaded with galectin-3 was developed as a delivery system. The influence of human recombinant galectin-3 in skin healing, when delivered topically and using an electrospun scaffold, was then investigated in wild type and diabetic mice. Electrospun ...