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331 full-text articles. Page 1 of 13.

The Sub-Chronic Vascular Response To Water-Borne Embolic Coacervates., Joshua P. Jones, Monika Sima, Russell J. Stewart 2017 University of Utah

The Sub-Chronic Vascular Response To Water-Borne Embolic Coacervates., Joshua P. Jones, Monika Sima, Russell J. Stewart

Biomedical Engineering Western Regional Conference

Water-borne coacervates that solidify in response to decreasing ionic strength have been developed as an agent for small vessel transcatheter embolization. Here, the sub-chronic vascular response to these agents will be presented. Embolic coacervates demonstrated a benign foreign body response, which supported tissue ingrowth and stabilized vessel occlusion out to 28 days. As with other liquid embolics, occlusion is dependent upon mechanical obstruction of the vessel and native thrombus. Over time, the thrombus becomes more organized by fibroblasts. Continuation of the processes seen at 28 days will likely result in fibrous encapsulation of the embolic coacervate, further stabilizing the occlusion.


Differentiation And Containment Of Derived Pancreatic Beta Cells, Caden Duffy, Alonzo Cook Ph.D. 2017 Brigham Young University - Provo

Differentiation And Containment Of Derived Pancreatic Beta Cells, Caden Duffy, Alonzo Cook Ph.D.

Biomedical Engineering Western Regional Conference

Currently, the only permanent cure for Type 1 Diabetes is a pancreatic or islet transplant. With the shortage of donors, we are progressing research towards alternative therapies by differentiating induced pluripotent stem cells into derived pancreatic β-cells that can be transplanted and used as treatment for Type 1 Diabetes. We are investigating methods to increase the yield of fully derived, insulin producing pancreatic β-cells and are additionally researching the use of hydrophilized expanded polytetrafluoroethylene for use in cell containment devices. These devices could offer a future alternative for islet transplantation in human patients.


Super-Hydrophobic And Anti-Microbial Surfaces Via Carbon Infiltrated-Carbon Nanotubes, Christian DaLon Esplin, Anton Bowden, Brian Jensen 2017 Brigham Young University

Super-Hydrophobic And Anti-Microbial Surfaces Via Carbon Infiltrated-Carbon Nanotubes, Christian Dalon Esplin, Anton Bowden, Brian Jensen

Biomedical Engineering Western Regional Conference

No abstract provided.


Structural Mrsa Resistance Through Carbon-Infiltrated Carbon Nanotube Coating Of External Fixator Pins, Jaclyn Larsen, Stephanie Morco, Brian Jensen, Anton Bowden 2017 Brigham Young University

Structural Mrsa Resistance Through Carbon-Infiltrated Carbon Nanotube Coating Of External Fixator Pins, Jaclyn Larsen, Stephanie Morco, Brian Jensen, Anton Bowden

Biomedical Engineering Western Regional Conference

No abstract provided.


Resorption Rate Of Bioresorbable Materials For Possible Use In Self-Expanding Stents, Jared R. Park, Jason Porter, Anton Bowden 2017 Brigham Young University

Resorption Rate Of Bioresorbable Materials For Possible Use In Self-Expanding Stents, Jared R. Park, Jason Porter, Anton Bowden

Biomedical Engineering Western Regional Conference

This study investigates the mechanical behavior of various polymers after a period of degradation from exposure to a Saline Solution. The study found that PLA and PDLLA do not have significant degradation over a period of 2 months, while PLA has a sharp decrease in strength after 7 days.


Effect Of Multiple Confined Compression/Stress Relaxation Cycles On Cross-Linked Alginate Pore Size., Sindhu Kolar Venkat, Erik L. Risa, Bergren Antell, Maryam Mobed-Miremadi 2017 Santa Clara University

Effect Of Multiple Confined Compression/Stress Relaxation Cycles On Cross-Linked Alginate Pore Size., Sindhu Kolar Venkat, Erik L. Risa, Bergren Antell, Maryam Mobed-Miremadi

Biomedical Engineering Western Regional Conference

No abstract provided.


Towards A Bioselective Surface For Treatment Of Sepsis In A Hemoperfusion Device, Karl F. Schilke, Ramya Raman, Bonan Yu, Erik Hahn, Jonathan Su 2017 Oregon State University

Towards A Bioselective Surface For Treatment Of Sepsis In A Hemoperfusion Device, Karl F. Schilke, Ramya Raman, Bonan Yu, Erik Hahn, Jonathan Su

Biomedical Engineering Western Regional Conference

Sepsis is a dysregulated immune response to circulating bacteria/endotoxin. Hemoperfusion is a promising treatment, but is not universally effective and can unacceptable blood damage. We are developing protein-repellent hydrogel nanofilms that can be grown on a variety of surfaces, and functionalized with “click-ready” pathogen-binding proteins expressed by Genetic Code Expansion (GCE). The extremely rapid, bioorthogonal “click” immobilization chemistry eliminates prior purification, maximizes surface loading, and guarantees spatial orientation of the immobilized proteins. We have demonstrated pathogen binding and blood protein repulsion by these layers, suggesting that they may be part of effective treatments for sepsis and other applications.


Molecular Modeling Of Antibody-Antigen Binding Near Solid Surfaces, Derek Bush, Thomas Knotts 2017 Brigham Young University

Molecular Modeling Of Antibody-Antigen Binding Near Solid Surfaces, Derek Bush, Thomas Knotts

Biomedical Engineering Western Regional Conference

Antibody microarrays are biosensors that have the potential to revolutionize molecular detection in medicine, scientific research, and national defense. However, current microarrays are not widely used due to problems including poor reproducibility and signal quality, unbalanced antibody performance, and cross-reactivity. Prior work in the area focused mainly on the stability of the antibody alone and not its affinity for its antigen. This presentation shows results of using molecular simulation to determine how different types of surfaces affect antigen binding to surface-tethered antibodies. The results offer an unprecedented, molecular-level view into these protein-protein-surface interactions and how to drive binding to occur.


Effect Of L-Ascorbic Acid And All-Trans Retinoic Acid On Smooth Muscle Cells Cultured On Pcl Scaffolds, Brandon Chaffay 2017 The University of Western Ontario

Effect Of L-Ascorbic Acid And All-Trans Retinoic Acid On Smooth Muscle Cells Cultured On Pcl Scaffolds, Brandon Chaffay

Electronic Thesis and Dissertation Repository

The aim of vascular tissue engineering (VTE) is to fabricate tissues that are both mechanically and biologically competent similar to the native vessel they are intended to replace. To this end, the incorporation of sufficient extracellular matrix elastin and collagen is important. The objective of this thesis work was to evaluate the effect of two biochemical factors, l-ascorbic acid (AA) and all-trans retinoic acid (atRA), on elastin synthesis when coronary artery smooth muscle cells were cultured on 3D polycaprolactone (PCL) scaffolds. First, porous PCL scaffolds were fabricated using a solvent casting and particulate leaching approach. The effect of different ...


Activity Preservation Of Plasmonic Biosensors With A Metal-Organic Framework, Lu Wang 2016 Washington University in St. Louis

Activity Preservation Of Plasmonic Biosensors With A Metal-Organic Framework, Lu Wang

Engineering and Applied Science Theses & Dissertations

Antibody-antigen recognition enables antibody-conjugated nanostructures to serve as plasmonic biosensors with tunable specificity. However due to the instability of antibodies, these biosensors are susceptible to changes in the environment such as heat and aridity, leading to constraints on the transportation and handling of these sensors. Here we establish a method using a metal-organic framework crystal to preserve biosensor activity under severe environmental conditions, including exposure to high temperatures, an organic solvent and a proteolytic agent. After zeolitic imidazolate framework-8 (ZIF-8) crystals formed for 12 hours on a biosensor of gold nanorods conjugated with a model antibody, rabbit IgG, 80% of ...


Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff 2016 University of Nebraska - Lincoln

Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff

Computer Science and Engineering: Theses, Dissertations, and Student Research

Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit them for novel purposes, such as the development of ubiquitous and heterogeneous communication networks to interconnect biological cells with nano and biotechnology-enabled devices, i.e., the Internet of Bio-Nano Things. One major problem in realizing these goals stands in the development of reliable techniques to control the engineered cells and their behavior from ...


A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox 2016 University of Maine

A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox

Electronic Theses and Dissertations

We explored the capabilities of additive manufacturing using a photo-cured jetted material 3D printer to manufacture a milli-microfluidic device with direct application in microalgae Dunaliella sp growth and intracellular compounds biosynthesis tests. A continuous microbioreactor for microalgae culture was CAD designed and successfully built in 1 hour and 49 minutes using black photopolymer cured by UV and a support material. The microreactor was made up of 2 parts including the bioreactor itself and a microchannel network for culture media fluids and microalgae. Both parts were assembled to form a single unit. Additional optical and auxiliar components were added. An external ...


Use Of A Modified Greenscreen Tool To Conduct A Screening-Level Comparative Hazard Assessment Of Conventional Silver And Two Forms Of Nanosilver., Jennifer Sass, Lauren Heine, Nina Hwang 2016 George Washington University

Use Of A Modified Greenscreen Tool To Conduct A Screening-Level Comparative Hazard Assessment Of Conventional Silver And Two Forms Of Nanosilver., Jennifer Sass, Lauren Heine, Nina Hwang

Environmental and Occupational Health Faculty Publications

BACKGROUND: Increased concern for potential health and environmental impacts of chemicals, including nanomaterials, in consumer products is driving demand for greater transparency regarding potential risks. Chemical hazard assessment is a powerful tool to inform product design, development and procurement and has been integrated into alternative assessment frameworks. The extent to which assessment methods originally designed for conventionally-sized materials can be used for nanomaterials, which have size-dependent physical and chemical properties, have not been well established. We contracted with a certified GreenScreen profiler to conduct three GreenScreen hazard assessments, for conventional silver and two forms of nanosilver. The contractor summarized publicly ...


Lipid Coated Microbubbles And Low Intensity Pulsed Ultrasound Enhance Chondrogenesis Of Human Mesenchymal Stem Cells In 3d Printed Scaffolds, Mitra Aliabouzar, Lijie Grace Zhang, Kausik Sarkar 2016 George Washington University

Lipid Coated Microbubbles And Low Intensity Pulsed Ultrasound Enhance Chondrogenesis Of Human Mesenchymal Stem Cells In 3d Printed Scaffolds, Mitra Aliabouzar, Lijie Grace Zhang, Kausik Sarkar

Medicine Faculty Publications

Lipid-coated microbubbles are used to enhance ultrasound imaging and drug delivery. Here we apply these microbubbles along with low intensity pulsed ultrasound (LIPUS) for the first time to enhance proliferation and chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in a 3D printed poly-(ethylene glycol)-diacrylate (PEG-DA) hydrogel scaffold. The hMSC proliferation increased up to 40% after 5 days of culture in the presence of 0.5% (v/v) microbubbles and LIPUS in contrast to 18% with LIPUS alone. We systematically varied the acoustic excitation parameters—excitation intensity, frequency and duty cycle—to find 30 mW/cm2, 1.5 ...


Surface Engineering Of Titanium Alloy To Stimulate The Bone Regeneration, Yubin Meng, Zhenduo Cui, Zhaoyang Li, Xue Li, Jin Zhao, Xubo Yuan, Xianjin Yang 2016 Tianjin University

Surface Engineering Of Titanium Alloy To Stimulate The Bone Regeneration, Yubin Meng, Zhenduo Cui, Zhaoyang Li, Xue Li, Jin Zhao, Xubo Yuan, Xianjin Yang

The 8th International Conference on Physical and Numerical Simulation of Materials Processing

No abstract provided.


Fluorescent Materials Design At Nanoscale For Biomedical Photonics In Near Infrared Window, Kohei Soga, Masao Kamimura 2016 Tokyo University of Science

Fluorescent Materials Design At Nanoscale For Biomedical Photonics In Near Infrared Window, Kohei Soga, Masao Kamimura

The 8th International Conference on Physical and Numerical Simulation of Materials Processing

No abstract provided.


Recent Approaches In Designing Bioadhesive Materials Inspired By Mussel Adhesive Protein, Pegah Kord Forooshani, Bruce P. Lee 2016 Michigan Technological University

Recent Approaches In Designing Bioadhesive Materials Inspired By Mussel Adhesive Protein, Pegah Kord Forooshani, Bruce P. Lee

Department of Biomedical Engineering Publications

Marine mussels secret protein-based adhesives, which enable them to anchor to various surfaces in a saline, intertidal zone. Mussel foot proteins (Mfps) contain a large abundance of a unique, catecholic amino acid, Dopa, in their protein sequences. Catechol offers robust and durable adhe-sion to various substrate surfaces and contributes to the curing of the adhesive plaques. In this article, we review the unique features and the key functionalities of Mfps, catechol chemistry, and strategies for preparing catechol-functionalized poly- mers. Specifically, we reviewed recent findings on the contributions of various features of Mfps on interfacial binding, which include coacervate formation, surface ...


Long-Term Biocompatibility, Imaging Appearance And Tissue Effects Associated With Delivery Of A Novel Radiopaque Embolization Bead For Image-Guided Therapy, Karun Sharma, Zainab Bascal, Hugh Kilpatrick, Koorosh Ashrafi, Sean L. Willis, Matthew R. Dreher, Andrew L. Lewis 2016 George Washington University

Long-Term Biocompatibility, Imaging Appearance And Tissue Effects Associated With Delivery Of A Novel Radiopaque Embolization Bead For Image-Guided Therapy, Karun Sharma, Zainab Bascal, Hugh Kilpatrick, Koorosh Ashrafi, Sean L. Willis, Matthew R. Dreher, Andrew L. Lewis

Pediatrics Faculty Publications

The objective of this study was to undertake a comprehensive long-term biocompatibility and imaging assessment of a new intrinsically radiopaque bead (LC Bead LUMI™) for use in transarterial embolization. The sterilized device and its extracts were subjected to the raft of ISO10993 biocompatibility tests that demonstrated safety with respect to cytotoxicity, mutagenicity, blood contact, irritation, sensitization, systemic toxicity and tissue reaction. Intra-arterial administration was performed in a swine model of hepatic arterial embolization in which 0.22–1 mL of sedimented bead volume was administered to the targeted lobe(s) of the liver. The beads could be visualized during the ...


Cartilage Engineering: Optimization Of Media For Chondrogenic Differentiation In Vitro, Evan Surma, Sherry L. Harbin, Hongji Zhang, Stacy Halum 2016 Purdue University

Cartilage Engineering: Optimization Of Media For Chondrogenic Differentiation In Vitro, Evan Surma, Sherry L. Harbin, Hongji Zhang, Stacy Halum

The Summer Undergraduate Research Fellowship (SURF) Symposium

Lower back pain from intervertebral disc injury affects around 84% of the population at some point in their life, which at its worst may cause total immobilization. This pain can only be temporarily relieved by spinal fusion or intervertebral disc replacement; however, both of these cause loss of natural motion in patients by removing damaged fibrocartilage discs. While these techniques help mitigate pain briefly, no permanent solution exists currently to both relieve pain and preserve natural motion. My work may be a solution by eventually providing patient-specific implants that resemble native tissue in the regeneration process that could be absorbed ...


Optimization Of The Design Of An Amphiphilic Biodegradable Polymer For Tissue-Engineering Application, Ben Zhang, Tera M. Filion, Jie Song 2016 University of Massachusetts Medical School

Optimization Of The Design Of An Amphiphilic Biodegradable Polymer For Tissue-Engineering Application, Ben Zhang, Tera M. Filion, Jie Song

Jie Song

Biodegradable polymers have been widely utilized as drug delivery vehicles and tissue engineering scaffolds. We previously designed amphiphilic triblock copolymer poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) (PELA) and its hydroxyapatite (HA) composites for bone tissue engineering applications. The hydrophilic electrospun PELA-HA composite exhibited aqueous stability and elastic handling characteristics, and was able to template the proliferation and osteogenesis of bone marrow stromal cells (BMSCs) in vitro and in vivo when spiral-wrapped into cylinders and press-fit into critical size femoral segmental defects in rats. However, the slow degradation of PELA has prevented timely disappearance of the scaffold and ...


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