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Using Mathematical Modeling To Unmask The Concealed Nature Of Long Qt-3 Syndrome, Steven Poelzing, Amara Greer-Short, Seth H. Weinberg 2016 Virginia Tech

Using Mathematical Modeling To Unmask The Concealed Nature Of Long Qt-3 Syndrome, Steven Poelzing, Amara Greer-Short, Seth H. Weinberg

Biology and Medicine Through Mathematics Conference

No abstract provided.


Diffusion Modeling And Device Development For Peritoneal Membrane Oxygenation, Liana Hatoum 2016 University of Nebraska - Lincoln

Diffusion Modeling And Device Development For Peritoneal Membrane Oxygenation, Liana Hatoum

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Acute respiratory distress syndrome (ARDS) is a pulmonary disease that causes hypoxemia and respiratory failure. The mortality rate for ARDS ranges between 27% and 45%. Current treatments including mechanical ventilation and extracorporeal membrane oxygenation (ECMO) are often associated with high risk complications including barotrauma, infection, thrombosis, and hemorrhage. Alternative pulmonary support techniques are needed to improve the survival rate of patients suffering from ARDS. Previous studies introducing pure O2 gas, perfluorocarbons and red blood cells into the intraperitoneal (IP) cavity have reported no effect or only a mild increase in oxygenation. Here we report peritoneal membrane oxygenation (PMO) using ...


Interaction Of Fibrinogen With Fibronectin: Purification And Characterization Of A Room Temperature-Stable Fibrinogen-Fibronectin Complex From Normal Human Plasma, Ayman E. Ismail 2016 University of Nebraska-Lincoln

Interaction Of Fibrinogen With Fibronectin: Purification And Characterization Of A Room Temperature-Stable Fibrinogen-Fibronectin Complex From Normal Human Plasma, Ayman E. Ismail

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

A fibrinogen-fibronectin complex (γγ’pdFI-pdFN) was purified from normal human plasma using a sequence of cryoprecipitation, ammonium sulfate fractionation, and DEAE Sepharose chromatography. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) under reducing condition showed both a 1:1 stoichiometric ratio of fibrinogen (FI) to fibronectin (FN) as well as a stoichiometric ratio of 1:1 of γg to gγ’. The γγ’pdFI-pdFN complex was non-covalent in nature as it was disrupted by affinity adsorption to Gelatin Sepharose where pdFN bound strongly and the disrupted γγ’pdFI fell through the chromatographic column. Surprisingly, the purified γγ’pdFI-pdFN complex was more broadly ...


Lesion Identification And The Effect Of Lesion On Motor Mapping After Stroke, Ruixi Zhou 2016 Biomedical Enigneering

Lesion Identification And The Effect Of Lesion On Motor Mapping After Stroke, Ruixi Zhou

Engineering and Applied Science Theses & Dissertations

Stroke is the most common cause of long-term severe disability and the motor system that is most commonly affected in stroke. One of the mechanisms that underlies recovery of motor deficits is reorganization or remapping of functional representations around the motor cortex. This mechanism has been shown in monkeys, but results in human subjects have been variable. In this thesis, I used a database that includes longitudinal behavioral and multimodal imaging data in both stroke patients and healthy controls for two research projects. Firstly, I improved an automatic lesion segmentation method to aid in the identification of the location and ...


Uses Of Textile Composite Materials In Orthopedics, Timothy L. Norman 2016 Cedarville University

Uses Of Textile Composite Materials In Orthopedics, Timothy L. Norman

Timothy L. Norman, Ph.D.

No abstract provided.


A Roadmap To Safe And Reliable Engineered Biological Nano-Communication Networks, Justin W. Firestone 2016 University of Nebraska - Lincoln

A Roadmap To Safe And Reliable Engineered Biological Nano-Communication Networks, Justin W. Firestone

Computer Science and Engineering: Theses, Dissertations, and Student Research

Synthetic biology has the potential to benefit society with novel applications that can improve soil quality, produce biofuels, grow customized biological tissue, and perform intelligent drug delivery, among many other possibilities. Engineers are creating techniques to program living cells, inserting new logic, and leveraging cell-to-cell communication, which result in changes to a cell's core functionality. Using these techniques, we can now create synthetic biological organisms (SBOs) with entirely new (potentially unseen) behaviors, which, similar to silicon devices, can sense, actuate, perform computation, and interconnect with other networks at the nanoscale level. SBOs are programmable evolving entities, and can be ...


Design Of Medical Devices For Diagnostics In The Gastrointestinal System, Charles R. Welch 2016 University of Nebraska-Lincoln

Design Of Medical Devices For Diagnostics In The Gastrointestinal System, Charles R. Welch

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

This thesis presents the design, controls, and testing of two systems: a novel colonoscope locomotion design for diagnostics, and a biosensor capsule that implants a sensor in the small intestine. Each system requires special design considerations for use in the gastrointestinal system.

Colonoscopy procedures are recommended as a screening for colon cancer and related conditions after the age of 50. The need for an improved colonoscope that reduces the colonoscopy time and patient discomfort is apparent. The semi-autonomous device presented here could likely reduce the colonoscopy procedure time by allowing the physician to focus more on the diagnosis and less ...


Spinal Implant Design And Subsidence: Finite Element Analysis, Samuel G. Stanaford, Timothy L. Norman 2016 Cedarville University

Spinal Implant Design And Subsidence: Finite Element Analysis, Samuel G. Stanaford, Timothy L. Norman

The Research and Scholarship Symposium

Artificial disc replacement and intervertebral fusion devices are alternatives to pain and spinal instability when disc failure occurs. Understanding the mechanical performance of these devices can be achieved by long term clinical studies, costly experimental studies or through numeral analysis using finite elements. This study was conducted to study the subsidence, or vertical motion of the artificial disc or fusion device into adjacent vertebral body segments. Specifically, the effect of implant size, shape and sagittal profile was studied using a finite element model of the L4/L5 human spine using ABAQUS finite element software. Results compared the stress state and ...


Spinal Implant Design And Subsidence, Schuyler E. Price, Lorrin Schoeneweis, Hannah Steele, Matthew Shomper, Timothy L. Norman 2016 Cedarville University

Spinal Implant Design And Subsidence, Schuyler E. Price, Lorrin Schoeneweis, Hannah Steele, Matthew Shomper, Timothy L. Norman

The Research and Scholarship Symposium

A spinal implant may be used in people who have diseased or injured intervertebral discs pushing against their spinal cord and nerves, causing them loss of sensation due to nerve impingement. Patients who have not found relief through non-surgical means may require a discectomy, which removes the disc and relieves the pressure. There are several ways to then fill the resulting gap which include fusion devices, artificial disc replacement (ADR) devices, or bone grafts. Our study focused on the first two mechanical options.

Subsidence, or the vertical movement of the device into the adjacent vertebral bodies, is an often reported ...


Development Of A Cao-Based Co2 Sorbent With Improved Cyclic Stability, Karl O. Albrecht, Kyle S. Wagenbach, Justinus A. Satrio, Brent H. Shanks, Thomas D. Wheelock 2016 Iowa State University

Development Of A Cao-Based Co2 Sorbent With Improved Cyclic Stability, Karl O. Albrecht, Kyle S. Wagenbach, Justinus A. Satrio, Brent H. Shanks, Thomas D. Wheelock

Thomas D. Wheelock

The carbonation of CaO is an attractive method for removing CO2 from hot gas mixtures. However, regeneration and reuse of a CaO-based sorbent causes a gradual decline in absorption capacity, which ultimately limits the life of the material. Various methods have been proposed for increasing the life cycle performance of a CaO-based sorbent. Two of these methods were selected for further investigation. One method incorporates an “inert” material in the sorbent, while a second method stabilizes the sorbent through controlled sintering. Promising results were achieved with both methods when they were applied separately to a sorbent derived from a natural ...


A Combined Catalyst And Sorbent For Enhancing Hydrogen Production From Coal Or Biomass, Justinus A. Satrio, Brent H. Shanks, Thomas D. Wheelock 2016 Iowa State University

A Combined Catalyst And Sorbent For Enhancing Hydrogen Production From Coal Or Biomass, Justinus A. Satrio, Brent H. Shanks, Thomas D. Wheelock

Thomas D. Wheelock

Future large-scale production of H2 for use as a clean fuel will likely depend upon gasifying coal or biomass followed by steam reforming the resulting gas mixture and separating the CO2 byproduct. The process of steam reforming and CO2 separation can be greatly simplified by utilizing a new material that combines a reforming catalyst with a sorbent for CO2. Such a material was prepared in the form of small pellets with cores made of calcium and magnesium oxides and shells made largely of alumina impregnated with a nickel catalyst. Subsequent laboratory performance tests of the material showed that CO, CH4 ...


Markerless Radiostereogammetry Of The Shoulder Joint In Humans: Comparisons Of Scapulohumeral Kinematics Between Individuals With Healthy And Supraspinatus-Impaired Shoulders, Ashley N. Hannon 2016 The University of Western Ontario

Markerless Radiostereogammetry Of The Shoulder Joint In Humans: Comparisons Of Scapulohumeral Kinematics Between Individuals With Healthy And Supraspinatus-Impaired Shoulders, Ashley N. Hannon

Electronic Thesis and Dissertation Repository

The purpose of this collection of studies was to further develop the knowledge of shoulder motion in order to better understand joint function through direct measurement of 3D scapulohumeral joint kinematics using a technique of high accuracy. Markerless, bi-planar fluoroscopic radiostereometric analysis using a generic shoulder model was developed in this thesis, reducing the amount of radiation exposure to subjects. The studies compared kinematic data of the scapulohumeral joint in six degrees of freedom with a precise, in-vivo measuring technique. Data were collected on young and older healthy individuals, individuals with a torn supraspinatus and post-surgical intervention.

Although this generic ...


A Numerical Approach To Investigate The Influence Of Deformable Blockages On Blood Flow In An Elastic Vessel, Tai-Hsien Wu 2016 Western Michigan University

A Numerical Approach To Investigate The Influence Of Deformable Blockages On Blood Flow In An Elastic Vessel, Tai-Hsien Wu

Research and Creative Activities Poster Day

In this work, we presented a new numerical approach to study the deformation of blockages and fluid properties in an elastic blood vessel. In computational hemodynamics, only few of the current numerical models considered the elasticity of vessels, and those models were difficult to extend to other topics like the deformation of blockages in elastic blood vessels. In addition, the approach that we employed is especially effective on visualization. A validation for the present method is carried out by comparing the simulation results with a theoretical prediction of the deformation of the pulmonary blood vessel in a steady flow. Subsequently ...


High-Performance Nanostructured Thermoelectric Generators For Micro Combined Heat And Power Systems, Yanliang Zhang, Xiaowei Wang, Martin Cleary, Luke Schoensee, Nicholas Kempf, Joseph Richardson 2016 Boise State University

High-Performance Nanostructured Thermoelectric Generators For Micro Combined Heat And Power Systems, Yanliang Zhang, Xiaowei Wang, Martin Cleary, Luke Schoensee, Nicholas Kempf, Joseph Richardson

Yanliang Zhang

Micro combined heat and power (micro-CHP) systems are promising pathways to increase power generation efficiencies. Here a new class of micro-CHP system without moving parts is experimentally demonstrated by integrating high-temperature thermoelectric generators (TEGs) and residential gas- fired boilers, thus enabling wide applications. The TEGs fabricated using high-efficiency nanostructured bulk half-Heusler alloys generate ultrahigh power density of 2.1 W/cm2 with 5.3% electrical efficiency under 500 °C temperature differences between the hot and cold sides. The TEG system harnesses the untapped exergy between the combustion gas and water, and converts thermal energy into electric power with 4 ...


Reflections Of College Students Promoting Engineering Through Biomechanical Outreach Activities Indicate Dual Benefits, Kimberly Edginton Bigelow 2016 University of Dayton

Reflections Of College Students Promoting Engineering Through Biomechanical Outreach Activities Indicate Dual Benefits, Kimberly Edginton Bigelow

Kimberly Edginton Bigelow

Recent work by the National Academy of Engineering revealed that the public has a poor understanding of what engineers actually do on a day-to-day basis. This issue is compounded for non-traditional fields in engineering, such as biomechanical engineering. This is particularly problematic as such fields could draw interest from students not interested in traditional engineering careers, resulting in increased diversity. To address this, mechanical engineering students taking an elective course, Biomechanical Engineering, were given an outreach assignment to teach at least one individual under the age of 18 about the field of biomechanical engineering through a hands-on activity. Students worked ...


Molecular Combing Of Dna Nanofibers And Comparison To Electrospinning, Tanner L. Buresh 2016 University of Nebraska-Lincoln

Molecular Combing Of Dna Nanofibers And Comparison To Electrospinning, Tanner L. Buresh

UCARE Research Products

The goal of these experiments was to create DNA nanofibers through the method of molecular combing (MC) and then compare the MC fibers to fibers created with electrospinning (ES). The experiment was designed and initial samples were created. After confirming that the method would succeed in creating DNA fibers, several parametric studies were performed in order to optimize the experiment and create the most uniform fibers possible. The parametric studies were done on the following variables: substrate material, pH level of DNA solution, and DNA solution concentration. After completion of all experiments, it was determined that although fibers could be ...


Under The Needle: Ergonomic Issues With Lethal Injection Protocols, Gabriella Hancock 2016 University of Central Florida

Under The Needle: Ergonomic Issues With Lethal Injection Protocols, Gabriella Hancock

Human Factors and Applied Psychology Student Conference

The institution of capital punishment represents one of the most contentious issues affecting societies today; and while the practice is only implemented in 58 countries, the controversy affects the world at large as over 60% of the human population lives in nations that condone the death penalty (Hali, 2015). In the United States, people who support capital punishment believe the practice to be an effective crime deterrent for potential criminals and therefore a prospective protective measure for law abiding citizens. Moreover, advocates defend their position by forwarding the argument that executions are ‘humane’; that use of lethal injection ensures that ...


Brain Tumor In A Dish: Glioma/Astrocyte Co-Cultures As A Model For In Vitro Studies, Erin Eickman, Christina Wilson, Srivatsan Kidambi 2016 University of Nebraska-Lincoln

Brain Tumor In A Dish: Glioma/Astrocyte Co-Cultures As A Model For In Vitro Studies, Erin Eickman, Christina Wilson, Srivatsan Kidambi

UCARE Research Products

This study seeks to engineer an in vitro co-culture model to elucidate the role of glioma-astrocyte interactions on molecular changes in the tumor microenvironment. The use of patterned co-cultures created with polyelectrolyte multilayers and micromolding in capillaries will allow tthe investigation of cell-cell communication. This study will lead to better understanding of the role of healthy cells in cancer progression and potential treatment options.


Circle Of Willis Model For Transcranial Doppler Ultrasound Training, Conner J. Beyersdorf, Ben Hage, Greg Bashford 2016 University of Nebraska-Lincoln

Circle Of Willis Model For Transcranial Doppler Ultrasound Training, Conner J. Beyersdorf, Ben Hage, Greg Bashford

UCARE Research Products

Transcranial Doppler (TCD) ultrasound is a technique involving the use of high frequency transmitters to measure intracranial blood flow. The brain is supplied by blood in an arterial anastomosis called the Circle of Willis. Using TCD ultrasound on the circle is difficult and requires practice and teaching. A functional model of the Circle of Willis could prove to be a valuable teaching tool. Through the use of AutoCAD and 3D printing software, an anatomically accurate model was created and set in gelatin phantom inside of a plastic skull. Milk was pumped through the model with a peristaltic pump to simulate ...


Exploring Oculomotor Trends In Collegiate Athletes, Brett Whorley, Julie A. Honaker 2016 University of Nebraska-Lincoln

Exploring Oculomotor Trends In Collegiate Athletes, Brett Whorley, Julie A. Honaker

UCARE Research Products

Collaborative efforts to improve athlete safety without significantly hindering the rules of the games aim to develop a novel system to better measure and diagnose concussions. Provided that common signs of concussions include blurred vision, distant gaze, and dizziness, the Dizziness and Balance Disorders Lab at UNL believes that the simple oculomotor exam studied in this project may be applied to this procedure. Within the broader goal to better understand the causes, signs, symptoms, and prognosis of concussions, researchers desired to further investigate the results of this oculomotor test. The aim was to identify and interpret correlations between collegiate athlete ...


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