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Biomedical Engineering and Bioengineering Commons

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Electrospinning Of Polycaprolactone Core-Shell Nanofibers With Anti-Cancer Drug, Sakib Iqbal, Mujibur Khan, Saheem Absar, Andrew Diamanduros, Samuel Chambers 2016 Georgia Southern University

Electrospinning Of Polycaprolactone Core-Shell Nanofibers With Anti-Cancer Drug, Sakib Iqbal, Mujibur Khan, Saheem Absar, Andrew Diamanduros, Samuel Chambers

Mujibur R. Khan

Encapsulation of a model anti-cancer drug, 5-Fluorouracul (5-FU) into biocompatible core-shell nanofibers of polycaprolactone (PCL) nanofibers was fabricated using a coaxial electrospinning process. Our work aims to solve these issues using a novel method of fabrication of fibers featuring confinement of drugs within a biodegradable core-shell structure, thereby permitting sustained release of drugs to specific sites of treatment, such as tissues affected with tumor cells. The coaxial electrospinning was performed using a sheath polymer solution consisting of a 14 wt% PCL solution and a 5 wt% solution of 5-FU as the core solution. Dimethylformamide (DMF) was used as the solvent ...


Using Mathematical Modeling To Unmask The Concealed Nature Of Long Qt-3 Syndrome, Steven Poelzing, Amara Greer-Short, Seth H. Weinberg 2016 Virginia Tech

Using Mathematical Modeling To Unmask The Concealed Nature Of Long Qt-3 Syndrome, Steven Poelzing, Amara Greer-Short, Seth H. Weinberg

Biology and Medicine Through Mathematics Conference

No abstract provided.


Pressure Relationships Of Inspired Air Into The Human Lung Bifurcations, Parya Aghasafari, Israr Ibrahim, Ramana Pidaparti 2016 University of Georgia

Pressure Relationships Of Inspired Air Into The Human Lung Bifurcations, Parya Aghasafari, Israr Ibrahim, Ramana Pidaparti

Biology and Medicine Through Mathematics Conference

No abstract provided.


High-Temperature And High-Power-Density Nanostructured Thermoelectric Generator For Automotive Waste Heat Recovery, Yanliang Zhang, Nicholas Kempf, Luke Schoensee 2016 Boise State University

High-Temperature And High-Power-Density Nanostructured Thermoelectric Generator For Automotive Waste Heat Recovery, Yanliang Zhang, Nicholas Kempf, Luke Schoensee

Yanliang Zhang

Given increasing energy use as well as decreasing fossil fuel sources worldwide, it is no surprise that interest in promoting energy efficiency through waste heat recovery is also increasing. Thermoelectric generators (TEGs) are one of the most promising pathways for waste heat recovery. Despite recent thermoelectric efficiency improvement in nanostructured materials, a variety of challenges have nevertheless resulted in few demonstrations of these materials for large-scale waste heat recovery. Here we demonstrate a high-performance TEG by combining high-efficiency nanostructured bulk materials with a novel direct metal brazing process to increase the device operating temperature. A unicouple device generates a high ...


A Cartesian Immersed Boundary Method To Simulate Stably Stratified Turbulent Flows, Clancy Umphrey, Rey DeLeon, Inanc Senocak 2016 Boise State University

A Cartesian Immersed Boundary Method To Simulate Stably Stratified Turbulent Flows, Clancy Umphrey, Rey Deleon, Inanc Senocak

Inanc Senocak

Turbulent katabatic (downslope) flow under stable stratification over a cool surface remains a poorly understood subject, which finds application in geophysical flows. This work investigates an immersed boundary (IB) formulation within a multi-graphics-processing-unit (GPU) parallel incompressible flow solver to impose velocity and heat flux boundary conditions to simulate fundamental katabatic flows. Prandtl's analytical solution for laminar katabatic flow is used to develop an IB formulation to impose heat flux boundary conditions, and to assess its formal order of accuracy. Direct numerical simulation of turbulent katabatic flow is then performed to investigate the applicability of proposed schemes in the turbulent ...


Can Neuromorphic Computer Vision Inform Vision Science? Disparity Estimation As A Case Study, Guido Maiello, Manuela Chessa, Peter J. Bex, Fabio Solari 2016 University College London

Can Neuromorphic Computer Vision Inform Vision Science? Disparity Estimation As A Case Study, Guido Maiello, Manuela Chessa, Peter J. Bex, Fabio Solari

MODVIS Workshop

The primate visual system efficiently and effectively solves a multitude of tasks from orientation detection to motion detection. The Computer Vision community is therefore beginning to implement algorithms that mimic the processing hierarchies present in the primate visual system in the hope of achieving flexible and robust artificial vision systems. Here, we reappropriate the neuroscience “borrowed” by the Computer Vision community and ask whether neuromorphic computer vision solutions may give us insight into the functioning of the primate visual system. Specifically, we implement a neuromorphic algorithm for disparity estimation and compare its performance against that of human observers. The algorithm ...


Modelling Short-Latency Disparity-Vergence Eye Movements Under Dichoptic Unbalanced Stimulation, Agostino Gibaldi, Guido Maiello, Peter J. Bex, Silvio P. Sabatini 2016 University of Genova

Modelling Short-Latency Disparity-Vergence Eye Movements Under Dichoptic Unbalanced Stimulation, Agostino Gibaldi, Guido Maiello, Peter J. Bex, Silvio P. Sabatini

MODVIS Workshop

Vergence eye movements align the optical axes of our two eyes onto an object of interest, thus facilitating the binocular summation of the images projected onto the left and the right retinae into a single percept. Both the computational substrate and the functional behaviour of binocular vergence eye movements have been the topic of in depth investigation. Here, we attempt to bring together what is known about computation and function of vergence mechanism. To this aim, we evaluated of a biologically inspired model of horizontal and vertical vergence control, based on a network of V1 simple and complex cells. The ...


Measuring And Modeling Shared Visual Attention, Jeffrey B. Mulligan, Patrick Gontar 2016 NASA Ames Research Center

Measuring And Modeling Shared Visual Attention, Jeffrey B. Mulligan, Patrick Gontar

MODVIS Workshop

Multi-person teams are sometimes responsible for critical tasks, such as flying an airliner. Here we present a method using gaze tracking data to assess shared visual attention, a term we use to describe the situation where team members are attending to a common set of elements in the environment. Gaze data are quantized with respect to a set of N areas of interest (AOIs); these are then used to construct a time series of N dimensional vectors, with each vector component representing one of the AOIs, all set to 0 except for the component corresponding to the currently fixated AOI ...


Agricultural Field Robotics For Plant Data Acquisition, Jeremy S. Blackford, Jared Werner, Tyler A. Troyer, Ethan Nutter 2016 university of Nebraska lincoln

Agricultural Field Robotics For Plant Data Acquisition, Jeremy S. Blackford, Jared Werner, Tyler A. Troyer, Ethan Nutter

UCARE Research Products

As the demand for food increases, we are presented with the challenge of producing food more efficiently. With the help of agricultural robots it will be possible to achieve greater yields by the application of seeds, fertilizers and chemicals in the most efficient way possible. With more advanced robotic systems accurate crop data can be obtained to improve farming products and techniques.

Flex-Row is a medium sized agricultural robotic platform built for autonomously traversing through rough fields during multiple crop growing stages. This platform consisting of a flexible frame with the ability to vary both width and height will initially ...


Next Generation Electrode, Joseph Daniel Bivona, Samuel Scott Dacus, Mary Harrell, James Frederick Weber Pike 2016 University of South Carolina - Columbia

Next Generation Electrode, Joseph Daniel Bivona, Samuel Scott Dacus, Mary Harrell, James Frederick Weber Pike

Theses and Dissertations

This senior thesis involves the results of a biomedical engineering senior design project where the group worked with Rhythmlink International LLC. The project involved the improvement of the manufacturing process of the Invisa Electrode, a CT compatible electrode sold and manufactured by Rhythmlink. The design of the electrode pin was altered to have a hollow center, where the lead wire can be inserted and heat welded, eliminating two key components of the original design and reducing production time and cost. The type of plastic used in the electrodes was also altered to be a 40% carbon loaded conductive plastic.


Orthopedic Drill System With Screw Length Measurement And Heat Sink System, Hunter Wilcox Rafoth, John Patrick Metz 2016 University of South Carolina - Columbia

Orthopedic Drill System With Screw Length Measurement And Heat Sink System, Hunter Wilcox Rafoth, John Patrick Metz

Theses and Dissertations

Most orthopedic drills currently on the market are rudimentary tools that serve only one purpose: to drill holes through bone. Biosphinx envisions a more versatile orthopedic drill that could serve multiple purposes in the operating room. This report outlines Biosphinx’s solution to design a new orthopedic drill system that would include several key features to improve bone screw length measurement, increase patient safety, and reduce time spent in the operating room.


Diffusion Modeling And Device Development For Peritoneal Membrane Oxygenation, Liana Hatoum 2016 University of Nebraska - Lincoln

Diffusion Modeling And Device Development For Peritoneal Membrane Oxygenation, Liana Hatoum

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Acute respiratory distress syndrome (ARDS) is a pulmonary disease that causes hypoxemia and respiratory failure. The mortality rate for ARDS ranges between 27% and 45%. Current treatments including mechanical ventilation and extracorporeal membrane oxygenation (ECMO) are often associated with high risk complications including barotrauma, infection, thrombosis, and hemorrhage. Alternative pulmonary support techniques are needed to improve the survival rate of patients suffering from ARDS. Previous studies introducing pure O2 gas, perfluorocarbons and red blood cells into the intraperitoneal (IP) cavity have reported no effect or only a mild increase in oxygenation. Here we report peritoneal membrane oxygenation (PMO) using ...


Interaction Of Fibrinogen With Fibronectin: Purification And Characterization Of A Room Temperature-Stable Fibrinogen-Fibronectin Complex From Normal Human Plasma, Ayman E. Ismail 2016 University of Nebraska-Lincoln

Interaction Of Fibrinogen With Fibronectin: Purification And Characterization Of A Room Temperature-Stable Fibrinogen-Fibronectin Complex From Normal Human Plasma, Ayman E. Ismail

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

A fibrinogen-fibronectin complex (γγ’pdFI-pdFN) was purified from normal human plasma using a sequence of cryoprecipitation, ammonium sulfate fractionation, and DEAE Sepharose chromatography. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) under reducing condition showed both a 1:1 stoichiometric ratio of fibrinogen (FI) to fibronectin (FN) as well as a stoichiometric ratio of 1:1 of γg to gγ’. The γγ’pdFI-pdFN complex was non-covalent in nature as it was disrupted by affinity adsorption to Gelatin Sepharose where pdFN bound strongly and the disrupted γγ’pdFI fell through the chromatographic column. Surprisingly, the purified γγ’pdFI-pdFN complex was more broadly ...


Lesion Identification And The Effect Of Lesion On Motor Mapping After Stroke, Ruixi Zhou 2016 Biomedical Enigneering

Lesion Identification And The Effect Of Lesion On Motor Mapping After Stroke, Ruixi Zhou

Engineering and Applied Science Theses & Dissertations

Stroke is the most common cause of long-term severe disability and the motor system that is most commonly affected in stroke. One of the mechanisms that underlies recovery of motor deficits is reorganization or remapping of functional representations around the motor cortex. This mechanism has been shown in monkeys, but results in human subjects have been variable. In this thesis, I used a database that includes longitudinal behavioral and multimodal imaging data in both stroke patients and healthy controls for two research projects. Firstly, I improved an automatic lesion segmentation method to aid in the identification of the location and ...


Stabilizing The Cold Plasma-Stimulated Medium By Regulating Medium’S Composition, Dayun Yan, Niki Nourmohammadi, Ka Bian, Ferid Murad, Jonathan H. Sherman, Michael Keidar 2016 George Washington University

Stabilizing The Cold Plasma-Stimulated Medium By Regulating Medium’S Composition, Dayun Yan, Niki Nourmohammadi, Ka Bian, Ferid Murad, Jonathan H. Sherman, Michael Keidar

Biochemistry and Molecular Medicine Faculty Publications

Over past several years, the cold plasma-stimulated medium (PSM) has shown its remarkable anti-cancer capacity in par with the direct cold plasma irradiation on cancer cells or tumor tissues. Independent of the cold plasma device, PSM has noticeable advantage of being a flexible platform in cancer treatment. Currently, the largest disadvantage of PSM is its degradation during the storage over a wide temperature range. So far, to stabilize PSM, it must be remained frozen at −80 °C. In this study, we first reveal that the degradation of PSM is mainly due to the reaction between the reactive species and specific ...


Wheelchair Fatigue Reducer, Aaron Miller, Dennis Andre Norfleet 2016 University of Tennessee, Knoxville

Wheelchair Fatigue Reducer, Aaron Miller, Dennis Andre Norfleet

University of Tennessee Honors Thesis Projects

No abstract provided.


Lost And Found: Use Of Gps Technology To Improve Storage Of Patient Belongings In Hospital Setting, Shelby A. Sievers, Griffin M. Heise, Min G. Kang, Michael Totty 2016 University of Tennessee, Knoxville

Lost And Found: Use Of Gps Technology To Improve Storage Of Patient Belongings In Hospital Setting, Shelby A. Sievers, Griffin M. Heise, Min G. Kang, Michael Totty

University of Tennessee Honors Thesis Projects

No abstract provided.


Mechanical Properties Of Poly (Vinyl Alcohol) Based Blends And Composites, Nazanin Afghan 2016 The University of Western Ontario

Mechanical Properties Of Poly (Vinyl Alcohol) Based Blends And Composites, Nazanin Afghan

Electronic Thesis and Dissertation Repository

One of the most important product specifications in design of materials for different applications is to closely match desired mechanical properties of the target. The soft tissue could be very elastic such as blood vessels and skin, whereas others are soft and non-elastic such as fat tissue. Soft human tissue has a diverse structural component that give them the different feel, texture, shape, and mechanical properties.

Poly (vinyl alcohol) (PVA) as hydrophobic polymer has outstanding features such as very good physico-mechanical properties, nontoxicity and biocompatibility, and high swelling properties which makes them favorable for biomaterial and biomedical applications. By physically ...


Uses Of Textile Composite Materials In Orthopedics, Timothy L. Norman 2016 Cedarville University

Uses Of Textile Composite Materials In Orthopedics, Timothy L. Norman

Timothy L. Norman, Ph.D.

No abstract provided.


Spinal Implant Design And Subsidence, Schuyler E. Price, Lorrin Schoeneweis, Hannah Steele, Matthew Shomper, Timothy L. Norman 2016 Cedarville University

Spinal Implant Design And Subsidence, Schuyler E. Price, Lorrin Schoeneweis, Hannah Steele, Matthew Shomper, Timothy L. Norman

Timothy L. Norman, Ph.D.

A spinal implant may be used in people who have diseased or injured intervertebral discs pushing against their spinal cord and nerves, causing them loss of sensation due to nerve impingement. Patients who have not found relief through non-surgical means may require a discectomy, which removes the disc and relieves the pressure. There are several ways to then fill the resulting gap which include fusion devices, artificial disc replacement (ADR) devices, or bone grafts. Our study focused on the first two mechanical options.

Subsidence, or the vertical movement of the device into the adjacent vertebral bodies, is an often reported ...


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