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Effect Of Temporal Onset Of Mechanical Loading On Tendon To Bone Healing, Determined With A Novel In-Vivo Device, Mark E. Stasiak 2016 Graduate Center, City University of New York

Effect Of Temporal Onset Of Mechanical Loading On Tendon To Bone Healing, Determined With A Novel In-Vivo Device, Mark E. Stasiak

All Dissertations, Theses, and Capstone Projects (2014-Present)

Background: Exposure to tensile loading has been shown to maintain tendon/ligament homeostasis, with the tensile modulus of the tissue increasing in response to greater loading frequency, and even decreasing in the absence of load. However after injury or surgical repair the effect of tensile load is controversial, with many studies implicating mechanical loading with impaired healing. It is currently unknown when the tensile loading imparted during rehabilitation exercise, can be safely reintroduced after surgical tendon repair or ligament reconstruction, and at what time point it can most benefit the remodeling process. To investigate the effect of tensile loading protocols ...


Equilibrium Testing Of Rat Tail Tendon: An Analysis Of The Viscoelastic Properties Of Collagen Under Different Strain Points, Joshua C. Witt 2016 Rose-Hulman Institute of Technology

Equilibrium Testing Of Rat Tail Tendon: An Analysis Of The Viscoelastic Properties Of Collagen Under Different Strain Points, Joshua C. Witt

Graduate Theses - Biology & Biomedical Engineering

Instantaneous tensile testing and stress-relaxation testing are forms of mechanical testing used to determine the elastic and viscoelastic properties of biological tissue. Equilibrium testing is a form of testing that combines both of these testing approaches at different strain points to determine the elastic properties of a material and also assess their viscoelastic properties in the same test. This testing method is commonly used on highly viscoelastic materials such as cartilage but has never been fully described in dense collagenous materials such as tendon or ligament. This analysis utilizes different strain points selected to capture the classic non-linear behavior of ...


Td Enzymo L3s5_2016.Pdf, Mamoudou H. DICKO, Prof. 2016

Td Enzymo L3s5_2016.Pdf, Mamoudou H. Dicko, Prof.

Pr. Mamoudou H. DICKO, PhD

Travaux Dirigés (TD) d'Enzymologie


Material Redesign Of A Lower Leg Sports Prosthesis, Alexander R. Hendricks, Matthew T. Siniawski 2015 Loyola Marymount University

Material Redesign Of A Lower Leg Sports Prosthesis, Alexander R. Hendricks, Matthew T. Siniawski

Research & Exhibition

In this research project, carbon fiber is explored as a potential replacement material for grade 5 titanium alloy in sports prosthesis. Grade 5 titanium alloy is the main structural component of current sports prosthesis, but as a material it has some key flaws. In order to make improvements in the field of sports prosthesis, carbon fiber is to be tested as a potential replacement material for titanium. Carbon fiber was chosen as it is seen as a very strong, new material and its potential to be used in various fields has been detailed by many scientists, designers, and engineers. The ...


High Throughput Screening Of Priming Candidates For Impact On Nonviral Gene Delivery, Albert L. Nguyen 2015 University of Nebraska-Lincoln

High Throughput Screening Of Priming Candidates For Impact On Nonviral Gene Delivery, Albert L. Nguyen

Biological Systems Engineering--Dissertations, Theses, and Student Research

Priming, in the context of nonviral gene delivery, is the treatment of cells with a compound prior to gene transfer that enhances transfection efficiency and/or transgene expression. Essentially, it is the application of an adjuvant approach to gene delivery. Effective transfection strategies may require priming to compete with the efficiency of viral transduction in order to achieve clinically relevant efficiency and expression in vivo. To search for priming compounds, a high throughput screen of the NIH Clinical Collection was performed using 25kDa b-PEI, an EGFP/luciferase plasmid, and HEK293T cells. The EGFP reporter was multiplexed with Hoechst 33342 and ...


Background Differences In Baseline And Stimulated Mmp Levels Influence Abdominal Aortic Aneurysm Susceptibility, Matthew A. Dale, Melissa K. Suh, Shijia Zhao, Trevor Meisinger, Linxia Gu, Vicki J. Swier, Devendra K. Agrawal, Timothy Greiner, Jeffrey S. Carson, B. Timothy Baxter, Wanfen Xiong 2015 University of Nebraska Medical Center

Background Differences In Baseline And Stimulated Mmp Levels Influence Abdominal Aortic Aneurysm Susceptibility, Matthew A. Dale, Melissa K. Suh, Shijia Zhao, Trevor Meisinger, Linxia Gu, Vicki J. Swier, Devendra K. Agrawal, Timothy Greiner, Jeffrey S. Carson, B. Timothy Baxter, Wanfen Xiong

Mechanical & Materials Engineering Faculty Publications

Objective: Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are less susceptible to aneurysm formation compared to the 129/SvEv genetic background. In this study, we hypothesize that susceptibility to abdominal aortic aneurysm (AAA) will be increased in 129/SvEv mice versus C57Bl/6 mice. We tested this hypothesis by assessing differences in aneurysm size, tissue properties, immune response, and MMP expression.

Methods: Mice of C57Bl/6 or ...


Feasibility Of Using Raman-Based Techniques For Breast Cancer Detection, Sara Mollamohammada 2015 University of Nebraska-Lincoln

Feasibility Of Using Raman-Based Techniques For Breast Cancer Detection, Sara Mollamohammada

Civil Engineering Theses, Dissertations, and Student Research

Breast cancer is one of the common types of cancer among women all over the world. Early diagnosis is an effective way that improve the treatment process and gives the patients a better chance of survival. Many of the patients infected by breast cancer choose breast conservation surgery (BCS). However, some of those will be subjected to mastectomy, and many will have tumor recurrence as there is no precise technique to show the tumor margins. Raman-based methods are powerful techniques with potential to rapidly differentiate normal from tumor tissues and provides a solution to detect tumor margin. This is because ...


The Effect Of Neurostimulation On Ischemic Pain And Methods Of Assessing Pain, Kaylee Keck 2015 California Polytechnic State University - San Luis Obispo

The Effect Of Neurostimulation On Ischemic Pain And Methods Of Assessing Pain, Kaylee Keck

Biomedical Eng/General Eng.

Peripheral arterial disease (PAD) impacts approximately eight million people in the United States [1]. Disease progression leads to chronic ischemic pain, hindering quality of life. Pharmaceuticals are a typical treatment for pain associated with PAD; but as few as 30% of patients have a significant reduction of pain (≥50%) [2].

Neurostimulation is commonly used as a treatment for various diseases and injuries, including Parkinson’s disease and sports-related back and knee injuries [2]. The objective of the study was to explore neurostimulation and its effect on pain and paresthesia for a model of acute peripheral ischemia in young college students ...


Novel Biomechanical Test Method For Cancellous Bone Screws And Screw Augmentation With Cement., Kevin Lancaster 2015 University of Louisville

Novel Biomechanical Test Method For Cancellous Bone Screws And Screw Augmentation With Cement., Kevin Lancaster

Electronic Theses and Dissertations

It is often difficult to achieve adequate screw fixation for plate constructs in fractures with poor quality bone or in metaphyseal bone with extensive bone loss or comminution[7][17]. Furthermore, rescuing or augmenting failed screw fixation in inadequate bone with various cement products has yielded mixed results when tested with pure axial pullout loading[20][21]. In most cases, plate/screw constructs experience both vertical (translational) and horizontal (pullout) forces during physiologic loading[17][20][21]. The increased use of locked screws in plate constructs has also changed the loading patterns of bone screws. For this study, a novel ...


Decellularized Bovine Nucleus Pulposus As A Biomimetic Scaffold For Intervertebral Disc Regeneration, Christopher Fernandez 2015 Clemson University

Decellularized Bovine Nucleus Pulposus As A Biomimetic Scaffold For Intervertebral Disc Regeneration, Christopher Fernandez

All Theses

Low back pain (LBP) is a significant burden with a lifetime prevalence of 84% and estimated expenditures of $85.9 billion.[1,2] Although LBP is multifactorial; it has been shown that LBP can originate from degenerating intervertebral discs (IVDs); a process which initiates in the nucleus pulposus (NP); a hydrated tissue primarily composed of type 2 collagen and proteoglycan. Current therapies for IVD degeneration (IDD) are palliative and merely delay surgical management. While these procedures may relieve pain temporarily, they fail to address the underlying cause of degeneration and make no attempt to regenerate the effected tissue. Additional concerns ...


Analysis Of Citrate Content In Bone Using High Performance Liquid Chromatography, Matthew Konstantin Pysh 2015 Clemson University

Analysis Of Citrate Content In Bone Using High Performance Liquid Chromatography, Matthew Konstantin Pysh

All Theses

Approximately 1.5 wt. % of bone is comprised of citrate molecules bound to the surface of apatite crystals. Furthermore, 80 to 90% of physiological citrate is contained within bone. Recently, interest in citrate has increased due to the potential of a citrate based method for estimation of postmortem intervals, time since death, of skeletal remains. The broad objective of this research was to develop and validate a High-Performance Liquid Chromatography (HPLC) method for quantitative and qualitative analysis of citrate in bone. An appropriate HPLC column and operating conditions for the detection of citrate were selected and subsequently used to analyze ...


Effects Of Growth Factor Supplementation And Environmental Conditions On Human Adipose-Derived Stem Cell Differentiation Towards Urothelial Lineage, James Turner 2015 Clemson University

Effects Of Growth Factor Supplementation And Environmental Conditions On Human Adipose-Derived Stem Cell Differentiation Towards Urothelial Lineage, James Turner

All Dissertations

In recent years, tissue engineering of the bladder has undergone many technological advances. Autologous urothelial cells have been used in animal models and have shown increased performance for ureteral reconstruction compared to unseeded grafts. However, since patients may lack a reliable source of native urothelial cells due to the nature of their specific bladder disease, autologous cells are not an ideal source clinically, and an alternate cell source must be explored. Adipose derived stem cells (ADSCs) are an attractive cell source for such regenerative medicine applications as they have been extensively studied for their multipotential differentiation, immunosuppressive properties, ease of ...


Icloudecg: A Mobile Cardiac Telemedicine System, David S. Clifford 2015 University of Tennessee - Knoxville

Icloudecg: A Mobile Cardiac Telemedicine System, David S. Clifford

Masters Theses

With rising healthcare costs and a substantially growing number of patients 65 or over, the benefits of telemedicine and patient self-monitoring systems are becoming increasingly evident. Patients, physicians, hospitals, and even insurance providers benefit from vigilant, cost-effective patient monitoring systems. This thesis describes the development of a portable, smart-phone connected system for continuous cardiac monitoring. The system is capable of continuously monitoring the conditions of the heart, automated detection of cardiac arrhythmias, and real-time notifying patients and physicians of the detected abnormalities. The system consists of four main subsystems: 1) a Bluetooth capable chest-strap ECG, 2) an Android-enabled mobile device ...


Removal Of Trace Organic Compounds In Domestic Wastewater Using Recirculating Packed-Bed Media Filters, Brittani Nikole Perez 2015 University of Tennessee - Knoxville

Removal Of Trace Organic Compounds In Domestic Wastewater Using Recirculating Packed-Bed Media Filters, Brittani Nikole Perez

Masters Theses

Pharmaceuticals and personal care products (PPCPs) are commonly detected in the environment resulting from their survival from conventional wastewater treatment systems. More information is needed about the fate and transfer of these trace organic compounds in domestic wastewater and their associated risks so that efficient strategies for their removal can be developed for both large/small scale treatment systems. This study aimed to determine whether onsite wastewater treatment systems were capable of providing PPCP removal, in addition to quantifying different forms of removal (biodegradation/sorption). A column study was constructed to determine the removal efficiencies of 3 target PPCPs, endocrine ...


Effects Of Varus Knee Alignment And Using Toe-Cages On Frontal Plane Knee Biomechanics In Stationary Cycling, Guangping Shen 2015 University of Tennessee - Knoxville

Effects Of Varus Knee Alignment And Using Toe-Cages On Frontal Plane Knee Biomechanics In Stationary Cycling, Guangping Shen

Masters Theses

Effects of varus knee alignment on the internal knee abduction moment (KAM) in walking has been widely studied. KAM has been shown to be closely associated with the development of medial knee osteoarthritis (OA). Despite the importance of the knee alignment, no studies have explored its effects on knee frontal plane biomechanics during stationary cycling. The purpose of this study was to examine the effects of varus knee alignment and using a toe-cage on the knee frontal plane biomechanics during stationary cycling. Eleven participants in each of the varus and neutral groups participated in the study. The participants performed in ...


Identifying And Predicting Rat Behavior Using Neural Networks, Jonathan A. Gettner 2015 California Polytechnic State University - San Luis Obispo

Identifying And Predicting Rat Behavior Using Neural Networks, Jonathan A. Gettner

Master's Theses and Project Reports

The hippocampus is known to play a critical role in episodic memory function. Understanding the relation between electrophysiological activity in a rat hippocampus and rat behavior may be helpful in studying pathological diseases that corrupt electrical signaling in the hippocampus, such as Parkinson’s and Alzheimer’s. Additionally, having a method to interpret rat behaviors from neural activity may help in understanding the dynamics of rat neural activity that are associated with certain identified behaviors.

In this thesis, neural networks are used as a black-box model to map electrophysiological data, representative of an ensemble of neurons in the hippocampus, to ...


The Role Of Visualization, Force Feedback, And Augmented Reality In Minimally Invasive Heart Valve Repair, Maria E. Currie 2015 The University of Western Ontario

The Role Of Visualization, Force Feedback, And Augmented Reality In Minimally Invasive Heart Valve Repair, Maria E. Currie

Electronic Thesis and Dissertation Repository

New cardiovascular techniques have been developed to address the unique requirements of high risk, elderly, surgical patients with heart valve disease by avoiding both sternotomy and cardiopulmonary bypass. However, these technologies pose new challenges in visualization, force application, and intracardiac navigation. Force feedback and augmented reality (AR) can be applied to minimally invasive mitral valve repair and transcatheter aortic valve implantation (TAVI) techniques to potentially surmount these challenges. Our study demonstrated shorter operative times with three dimensional (3D) visualization compared to two dimensional (2D) visualization; however, both experts and novices applied significantly more force to cardiac tissue during 3D robotics-assisted ...


Nutritional And Anti-Nutrient Composition Of Three Kola Nuts (Cola Nitida, Cola Acuminata And Garcinia Kola) Produced In Benin, Durand Dah-Nouvlessounon, Aziz SINA, Pacôme Noumavo, Nafan DIARASSOUBA, Charles Parkouda, Yann Madodé, Mamoudou H. DICKO, Prof., Lamine Baba-MOUSSA 2015

Nutritional And Anti-Nutrient Composition Of Three Kola Nuts (Cola Nitida, Cola Acuminata And Garcinia Kola) Produced In Benin, Durand Dah-Nouvlessounon, Aziz Sina, Pacôme Noumavo, Nafan Diarassouba, Charles Parkouda, Yann Madodé, Mamoudou H. Dicko, Prof., Lamine Baba-Moussa

Pr. Mamoudou H. DICKO, PhD

Kola nuts were regularly chewed by West Africans and Beninese in particularly. The aim of this
study was to investigate nutritional and anti-nutrient content of three Benin’s kola nuts (Cola nitida,
Cola acuminata and Garcinia kola). Proximate composition of the three species of kola nuts
was assessed using standard analytical AOAC methods. Phenolics and flavonoids contents were
determined by Folin-Ciocalteu and aluminum trichloride methods, respectively. Mineral composition
was determined by Atomic Absorption Spectrometry method. Free and total amino acids were
separated and quantified by HPLC. Protein content of the three kola nuts ranges from 4.95% (G.
kola) to ...


Determination Of The Frequency Response Of An End Tidal Co2 Analyser, Kabita Shakya, Catherine Deegan, Fran Hegarty 2015 Dublin Institute of Technology

Determination Of The Frequency Response Of An End Tidal Co2 Analyser, Kabita Shakya, Catherine Deegan, Fran Hegarty

The ITB Journal

In a health care environment, mechanical ventilation is used to support patients during acute illness and surgery. Mechanical ventilation is the process by which the patient’s respiratory function is artificially supported using a respirator. During mechanical ventilation, it is necessary to ensure the adequacy of ventilation. The patient is thus monitored for several ventilatory parameters. The end-tidal CO2 (EtCO2) is one of the primary monitoring parameters. EtCO2 is the partial pressure or maximal concentration of carbon dioxide (CO2) at the end of an exhaled breath, which is expressed as a percentage of CO2 or mmHg . Capnography is the technique ...


The Development Of A Novel Polymer Based System For Gene Delivery, Anh Van Le 2015 FIU

The Development Of A Novel Polymer Based System For Gene Delivery, Anh Van Le

FIU Electronic Theses and Dissertations

Gene therapy involves the use of nucleic acids, either DNA or RNA for the treatment, cure, or prevention of human diseases. Synthetic cationic polymers are promising as a tool for gene delivery because of their high level of design flexibility for biomaterial construction and are capable of binding and condensing DNA through electrostatic interactions.

Our lab has developed a novel polymer (poly (polyethylene glycol-dodecanoate) (PEGD), a polyester of polyethylene glycol (PEG) and dodecanedioic acid (DDA). PEGD is a linear viscous polymer that self-assembles into a vesicle upon immersion in an aqueous solution. A copolymer of dodecanedioc acid and polyethylene glycol ...


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