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Biomedical Engineering and Bioengineering Commons

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Spontaneous Firing Of Sensory Neurons Modulates The Gain In The Downstream Circuit Of A Simple Olfactory System, Matthew O'Neill 2015 Washington University in St Louis

Spontaneous Firing Of Sensory Neurons Modulates The Gain In The Downstream Circuit Of A Simple Olfactory System, Matthew O'Neill

Engineering and Applied Science Theses & Dissertations

In locusts and other insects, odorants are transduced into electrical signal by the olfactory receptor neurons and transmitted to central circuits for further processing. Previous studies have shown that exogenous variables (e.g., flow rates, humidity, temperature, odor mixtures, etc.) can influence the responses of the sensory neurons and therefore modulate the central circuits. However, how the sensory neuron activity is manipulated to achieve adaptive gain control in the following circuit is yet to be understood. It is possible that the magnitude of the stimulus-evoked response in the receptor neurons, their spontaneous activity, or both of these factors can change ...


Characterization And Performance Of Algal Biofilms For Wastewater Treatment And Industrial Applications, Maureen Kesaano 2015 Utah State University

Characterization And Performance Of Algal Biofilms For Wastewater Treatment And Industrial Applications, Maureen Kesaano

All Graduate Theses and Dissertations

This study was carried out on algal biofilms grown using rotating algal biofilm reactors (RABRs) with the aim of: i) characterizing their growth in terms of photosynthetic activity and morphology ii) evaluating their performance as a wastewater treatment option and a feedstock for biofuels production, and iii) examining the algal-bacteria interactions.

A review of algal biofilm technologies currently employed in wastewater treatment processes was made to compare nutrient removal efficiencies, factors that influenced algal biofilm growth, and the different bioproducts generated from algal biomass. Consequently, research efforts were directed towards addressing pertinent issues identified in literature in order to optimize ...


Safety And Efficacy Results Of Switch From Imiglucerase To Velaglucerase Alfa Treatment In Patients With Type 1 Gaucher Disease, Deborah Elstein, Atul Mehta, Derralynn A. Hughes, Pilar Giraldo, Joel Charrow, Laurie Smith, Suma P. Shankar, Thomas N. Hangartner, Yune Kunes, Nan Wang, Eric Crombez, Ari Zimran 2015 Wright State University - Main Campus

Safety And Efficacy Results Of Switch From Imiglucerase To Velaglucerase Alfa Treatment In Patients With Type 1 Gaucher Disease, Deborah Elstein, Atul Mehta, Derralynn A. Hughes, Pilar Giraldo, Joel Charrow, Laurie Smith, Suma P. Shankar, Thomas N. Hangartner, Yune Kunes, Nan Wang, Eric Crombez, Ari Zimran

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Gaucher disease (GD) is a lysosomal storage disorder; symptomatic patients with type 1 GD need long-term disease-specific therapy of which the standard of care has been enzyme replacement therapy (ERT). Thirty-eight of 40 patients (aged 9–71 years) clinically stable on ERT with imiglucerase, safely switched to a comparable dose of velaglucerase alfa (units/kg) during TKT034, a 12-month, open-label clinical study, and for 10–50 months in an extension study. The most common adverse events (AEs) judged to be drug-related in the extension were fatigue and bone pain. No drug-related serious AEs were reported. No AEs led to study ...


Velaglucerase Alfa (Vpriv) Enzyme Replacement Therapy In Patients With Gaucher Disease: Long-Term Data From Phase Iii Clinical Trials, Derralynn A. Hughes, Derlis Gonzalez, Elena A. Lukina, Atul Mehta, Madhulika Kabra, Deborah Elstein, Isaac Kisinovsky, Pilar Giraldo, Ashish Bavdekar, Thomas N. Hangartner, Nan Wang, Eric Crombez, Ari Zimran 2015 Wright State University - Main Campus

Velaglucerase Alfa (Vpriv) Enzyme Replacement Therapy In Patients With Gaucher Disease: Long-Term Data From Phase Iii Clinical Trials, Derralynn A. Hughes, Derlis Gonzalez, Elena A. Lukina, Atul Mehta, Madhulika Kabra, Deborah Elstein, Isaac Kisinovsky, Pilar Giraldo, Ashish Bavdekar, Thomas N. Hangartner, Nan Wang, Eric Crombez, Ari Zimran

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Type 1 Gaucher disease is an inherited lysosomal enzyme deficiency with variable age of symptom onset. Common presenting signs include thrombocytopenia, anemia, hepatosplenomegaly, bone abnormalities, and, additionally in children, growth failure. Fifty-seven patients aged 3–62 years at the baseline of two phase III trials for velaglucerase alfa treatment were enrolled in the single extension study. In the extension, they received every-other-week velaglucerase alfa intravenous infusions for 1.2–4.8 years at 60 U/kg, although 10 patients experienced dose reduction. No patient experienced a drug-related serious adverse event or withdrew due to an adverse event. One patient died ...


A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device, Taylor Davis 2015 California Polytechnic State University - San Luis Obispo

A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device, Taylor Davis

Biomedical Eng/General Eng.

The company G-Force CRC LLC is currently experiencing the dichotomy of the FDA's conflicting role right now as they begin to approach FDA approval. G-Force CRC LLC is a small medical device company headquartered in San Diego, CA. The owner of the company, Dr. Ian Purcell, is an Otoneurologist apart of Alvarado Hospital. His medical practice mainly deals with patients who have balance disorders and therefore the devices that he has developed over the last 6+ years are primarily used to assist in the diagnosis of those balance disorders. G-Force CRC LLC was officially created in the summer of ...


Sapien3 Comb Stitch Improvement For Edwards Lifesciences, William Harley, Thomas Pluschkell, John McTigue, Garrett Reed 2015 California Polytechnic State University - San Luis Obispo

Sapien3 Comb Stitch Improvement For Edwards Lifesciences, William Harley, Thomas Pluschkell, John Mctigue, Garrett Reed

Mechanical Engineering

The complete senior project report was submitted to the project advisor and sponsor. The results of this project are of a confidential nature and will not be published at this time.


Transcatheter Heart Valve Subassembly Device, Adam Aslam, Matthew Bezkrovny, Daniel DeGree 2015 California Polytechnic State University - San Luis Obispo

Transcatheter Heart Valve Subassembly Device, Adam Aslam, Matthew Bezkrovny, Daniel Degree

Mechanical Engineering

No abstract provided.


Renal Artery Stent Fatigue Test, Braden Cooper, Munir Eltal, Jennifer Hawthorne, Ashley Schaefer 2015 California Polytechnic State University - San Luis Obispo

Renal Artery Stent Fatigue Test, Braden Cooper, Munir Eltal, Jennifer Hawthorne, Ashley Schaefer

Mechanical Engineering

In today’s world of medical innovation, regulations and requirements set by organizations such as the Food and Drug Administration (FDA), the International Organization for Standardization (ISO), and ASTM International (American Society for Testing and Materials) can inhibit rapid innovation by demanding rigorous testing of new designs. For arterial stents, the standard is that each design must be tested to simulate 10 years of life in an environment congruent to an in vivo environment. Endologix in Irvine, California develops and manufactures minimally invasive treatments for aortic diseases, with a focus on stent grafts for the treatment of abdominal aortic aneurysms ...


Multiphysics Modeling To Enhance Understanding Of Microwave Heating Of Food In Domestic Ovens, Jiajia Chen 2015 University of Nebraska-Lincoln

Multiphysics Modeling To Enhance Understanding Of Microwave Heating Of Food In Domestic Ovens, Jiajia Chen

Biological Systems Engineering--Dissertations, Theses, and Student Research

Nonuniform heating is the biggest issue in the microwave heating of prepared meals. Multiphysics based models are promising tools to improve microwave heating uniformity by properly designing the food product. However, limited availability of accurate temperature-dependent material properties, inadequate model prediction accuracy, and high computational power and complexity in model development are three gaps that greatly limited the application of these models in the food industry.

To fill in the gaps, firstly, we developed a multitemperature calibration protocol to measure temperature-dependent dielectric properties (dielectric constant and loss factor). The temperature-dependent dielectric and thermal (thermal conductivity and specific heat capacity) properties ...


Computational Fluid Dynamics Applied To The Analysis Of Blood Flow Through Central Aortic To Pulmonary Artery Shunts, Carey Celestin Jr 2015 University of New Orleans

Computational Fluid Dynamics Applied To The Analysis Of Blood Flow Through Central Aortic To Pulmonary Artery Shunts, Carey Celestin Jr

University of New Orleans Theses and Dissertations

This research utilizes CFD to analyze blood flow through pathways representative of central shunts, commonly used as part of the Fontan procedure to treat cyanotic heart disease. In the first part of this research, a parametric study of steady, Newtonian blood flow through parabolic pathways was performed to demonstrate the effect that flow pathway curvature has on wall shear stress distribution and flow energy losses. In the second part, blood flow through two shunts obtained via biplane angiograms is simulated. Pressure boundary conditions were obtained via catheterization. Results showed that wall shear stresses were of sufficient magnitude to initiate platelet ...


Biosensing Enhancement Of Dengue Virus Using Microballoon Mixers On Centrifugal Microfluidic Platforms, 2015 SelectedWorks

Biosensing Enhancement Of Dengue Virus Using Microballoon Mixers On Centrifugal Microfluidic Platforms

Faculty of Engineering University of Malaya

Dengue is the current leading cause of death among children in several Latin American and Asian countries. Due to poverty in areas where the disease is prevalent and the high cost of conventional diagnostic systems, low cost devices are needed to reduce the burden caused by dengue infection. Centrifugal microfluidic platforms are an alternative solution to reduce costs and increase the availability of a rapid diagnostic system. The rate of chemical reactions in such devices often depends on the efficiency of the mixing techniques employed in their microfluidic networks. This paper introduces a micromixer that operates by the expansion and ...


Gold Nanostructures For Sensing And Functional Bioimaging, Maximilian Y. Fei 2015 Washington University in St Louis

Gold Nanostructures For Sensing And Functional Bioimaging, Maximilian Y. Fei

Engineering and Applied Science Theses & Dissertations

Gold nanostructures offer an extremely promising path forward in the fields of imaging and sensing because of their unique optical and chemical properties. Here, we demonstrate that plasmonic nanostructures can be employed as nanoscale transducers to monitor the growth and phase transitions in ultrathin polymer films. In particular, gold nanorods with high refractive index sensitivity (~150 nm / refractive index unit (RIU)) were employed to probe the growth and swelling of polyelectrolyte multilayers (PEM). By comparing the wavelength shift and extinction intensity of the localized surface plasmon resonance (LSPR) of the gold nanorods coated with PEM in air and water, the ...


Regional Anesthesiology Ultrasound-Guided Nerve Block Simulator, Avik Purkayastha, David Call, Mehdi Zare, Michael Fister 2015 University of Tennessee, Knoxville

Regional Anesthesiology Ultrasound-Guided Nerve Block Simulator, Avik Purkayastha, David Call, Mehdi Zare, Michael Fister

Biomedical and Diagnostic Sciences Publications and Other Works

The purpose of the model is to allow residents in anesthesiology to practice the ultrasound guided supraclavicular nerve block procedure without having to practice on an actual patient so that they can hone their skills before performing the actual procedure. Our goals when creating the device were having a life-like feel, having the model be anatomically correct, and having the model provide an accurate ultrasound. After 3 iterations we were able to satisfy all 3 requirements but the most accurate ultrasound was provided by the second model, which did we believed did not satisfy the other requirements well enough. For ...


A Space-Variant Model For Motion Interpretation Across The Visual Field, Guido Maiello, Manuela Chessa, Peter J. Bex, Fabio Solari 2015 University College London

A Space-Variant Model For Motion Interpretation Across The Visual Field, Guido Maiello, Manuela Chessa, Peter J. Bex, Fabio Solari

MODVIS Workshop

We implement a neural model for the estimation of the focus of radial motion (FRM) at different retinal locations and we assess the model by comparing its results with respect to the precision with which human observers can estimate the FRM in naturalistic, moving dead leaves stimuli. The proposed neural model describes the deep hierarchy of the first stages of the dorsal visual pathway [Solari et al., 2014]. Such a model is space-variant, since it takes into account the retino-cortical transformation of the primate visual system through log-polar mapping that produces a cortical representation of the visual signal to the ...


Fiber Optic Bandage, Logan McNeil, Cameron Pilkey, Brittani Erwin, Adam Wojnar 2015 University of Tennessee - Knoxville

Fiber Optic Bandage, Logan Mcneil, Cameron Pilkey, Brittani Erwin, Adam Wojnar

Biomedical and Diagnostic Sciences Publications and Other Works

The purpose of this document is to show the report for the Fiber optic device formulated through the biomedical engineering department with a senior design group. A growing issue in medical technology is open wound care. Particularly prevalent in diabetics, open wound care is expensive and time consuming. Certain wavelengths of light have not only shown to have germicidal properties, but also allow cell growth and regeneration. The following design was founded around these ideas, and an initial design was developed. The design centered around using fiber optics as a means of replacing a wet bandage in a normal wound ...


3d Printing In Healthcare, Caleb Branch 2015 St. John Fisher College

3d Printing In Healthcare, Caleb Branch

Undergraduate Review: A Journal of Undergraduate Student Research

Technology is everywhere. Technology surrounds every aspect of 21st century life. It is in the cell phones we use, the cars we drive, and even the food we eat. A large portion of modern technology used is taken for granted and overlooked. Despite this, some technology fields continue to grow. Biomedical engineering, specifically 3D printing’s applications to healthcare, has been often overlooked until. Regardless of its status in the mainstream, 3D printing is prosperous in healthcare and its future looks bright. This piece analyzes 3D printing in healthcare. It hones in on the finer details of each specific ...


Fiber Optic Bandage, Logan McNeil 2015 University of Tennessee, Knoxville

Fiber Optic Bandage, Logan Mcneil

University of Tennessee Honors Thesis Projects

No abstract provided.


Ultrasound-Guided Regional Anesthesia Nerve Block Simulator, Avik Purkayastha, David Call, Alex Zare, Michael Fister 2015 University of Tennessee, Knoxville

Ultrasound-Guided Regional Anesthesia Nerve Block Simulator, Avik Purkayastha, David Call, Alex Zare, Michael Fister

University of Tennessee Honors Thesis Projects

No abstract provided.


Mitochondrial Dysfunction And Loss Of Glutamate Uptake In Primary Astrocytes Exposed To Titanium Dioxide Nanoparticles, Christina L. Wilson 2015 University of Nebraska-Lincoln

Mitochondrial Dysfunction And Loss Of Glutamate Uptake In Primary Astrocytes Exposed To Titanium Dioxide Nanoparticles, Christina L. Wilson

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

The proper function of astrocytes is critical for brain health as they are the most abundant cells in the brain which monitor ion homeostasis, recycle neurotransmitters and respond to tissue damage therefore disruption in astrocyte function can result in overall detrimental effects and has been linked with neurodegenerative diseases. Titanium Dioxide (TiO2) nanoparticles are currently the second most produced engineered nanomaterial in the world with vast usage in consumer products leading to recurrent human exposure. Animal studies indicate significant nanoparticle accumulation in the brain while cellular toxicity studies demonstrate negative effects on neuronal cell viability and function. However, the ...


Vcare: A Personal Emergency Response System To Promote Safe And Independent Living Among Elders Staying By Themselves In Community Or Residential Settings, Priyankar Bhattacharjee 2015 University of Nebraska-Lincoln

Vcare: A Personal Emergency Response System To Promote Safe And Independent Living Among Elders Staying By Themselves In Community Or Residential Settings, Priyankar Bhattacharjee

Dissertations & Student Research in Computer Electronics & Engineering

‘Population aging’ is a growing concern for most of us living in the twenty first century, primarily because many of us in the next few years will have a senior person to care for - spending money towards their healthcare expenditures AND/OR having to balance a full-time job with the responsibility of care-giving, travelling from another city to be with this elderly citizen who might be our parent, grand-parent or even community elders. As informal care-givers, if somehow we were able to monitor the day-to-day activities of our elderly dependents, and be alerted when wrong happens to them that would ...


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