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Blood Supply To The Brain Via The Carotid Arteries: Examining Obstructive And Sclerotic Disorders Using Theoretical And Experimental Models, Onaizah Onaizah 2015 The University of Western Ontario

Blood Supply To The Brain Via The Carotid Arteries: Examining Obstructive And Sclerotic Disorders Using Theoretical And Experimental Models, Onaizah Onaizah

Electronic Thesis and Dissertation Repository

Stroke remains one of the leading causes of death in North America. Approximately half of all ischemic episodes are a direct result of carotid artery disease, which can be categorized into either obstructive or sclerotic disease. Obstructive disease is a result of plaque development that imposes a direct limitation on the physical space available for blood flow. Sclerotic disease involves the hardening of the arteries as is often a result of aging and disease. While the impact of vessel stiffening is not as obvious, it does interfere with wave propagation. Effects of obstructive and sclerotic disease were studied using a ...


Spontaneous Firing Of Sensory Neurons Modulates The Gain In The Downstream Circuit Of A Simple Olfactory System, Matthew O'Neill 2015 Washington University in St Louis

Spontaneous Firing Of Sensory Neurons Modulates The Gain In The Downstream Circuit Of A Simple Olfactory System, Matthew O'Neill

Engineering and Applied Science Theses & Dissertations

In locusts and other insects, odorants are transduced into electrical signal by the olfactory receptor neurons and transmitted to central circuits for further processing. Previous studies have shown that exogenous variables (e.g., flow rates, humidity, temperature, odor mixtures, etc.) can influence the responses of the sensory neurons and therefore modulate the central circuits. However, how the sensory neuron activity is manipulated to achieve adaptive gain control in the following circuit is yet to be understood. It is possible that the magnitude of the stimulus-evoked response in the receptor neurons, their spontaneous activity, or both of these factors can change ...


Passive Acoustic Emissions Monitoring Of Fluidized Bed Pellet Coating, Taylor Sheahan 2015 The University of Western Ontario

Passive Acoustic Emissions Monitoring Of Fluidized Bed Pellet Coating, Taylor Sheahan

Electronic Thesis and Dissertation Repository

Passive acoustic emissions were assessed for their potential as a non-invasive monitoring tool for the coating of pellets in a fluidized bed. Pharmaceutical pellets are small spherical particles that contain an active ingredient. They are film coated for the purpose of modified drug release and packed into capsules as a multiple unit dosage form. A more reliable monitoring and control method is desired to ensure the appropriate drug release profile is achieved by minimizing variations within and between coated pellets.

Microphones attached to the exterior of a conical top spray fluidized bed measured acoustic emissions produced from the coating process ...


Microengineering The Neural Tube, Christopher Demers 2015 University of Maine - Main

Microengineering The Neural Tube, Christopher Demers

Electronic Theses and Dissertations

Early embryonic development is a complex and highly regulated orchestra of instructive cues that collectively guide naïve stem cells towards progressively more specialized fates. In the neural tube, the precursor structure to the brain and spinal cord, these signals emanate from ‘organizing centers’ surrounding the neural tube. These organizing centers send out soluble cues or morphogens that diffuse tens to hundreds of microns to recipient cells residing in the neural tube. Re-creating this dynamic landscape of cues in vitro is impossible using standard cell culture tools and techniques. However, microfluidics is perfectly suited to fill this gap, allowing precise control ...


In Vivo Mechanics Of Cam-Post Engagement In Fixed And Mobile Bearing Tka And Vibroarthrography Of The Knee Joint, Sumesh M. Zingde 2015 University of Tennessee - Knoxville

In Vivo Mechanics Of Cam-Post Engagement In Fixed And Mobile Bearing Tka And Vibroarthrography Of The Knee Joint, Sumesh M. Zingde

Doctoral Dissertations

The objective of this dissertation was to determine the mechanics of the cam-post mechanism for subjects implanted with a Rotating Platform (RP) PS TKA, Fixed Bearing (FB) PS TKA or FB Bi-Cruciate Stabilized (BCS) TKA. Additionally, a secondary goal of this dissertation was to investigate the feasibility of vibroarthrography in correlating in-vivo vibrations with features exhibited in native, arthritic and implanted knees. In-vivo, 3D kinematics were determined for subjects implanted with nine knees with a RP-PS TKA, five knees with a FB-PS TKA, and 10 knees with a FB-BCS TKA, while performing a deep knee bend. Distance between the cam-post ...


Alternating Current Electrokinetics Based Capacitive Affinity Biosensor: A Point-Of-Care Diagnostic Platform, Haochen Cui 2015 University of Tennessee - Knoxville

Alternating Current Electrokinetics Based Capacitive Affinity Biosensor: A Point-Of-Care Diagnostic Platform, Haochen Cui

Doctoral Dissertations

Capacitive bioaffinity detection using microelectrodes is considered as a promising label-free method for point-of-care diagnosis, though with challenges in sensitivity, specificity and the time “from sample to result.” This work presents an alternating current (AC)-electrokinetic based capacitive affinity sensing method that is capable of realizing rapid in-situ detection of specific biomolecular interactions such as probe-analyte binding. The capacitive biosensor presented here employs elevated AC potentials at a fixed frequency for impedimetric interrogation of the microelectrodes. Such an AC signal is capable of inducing dielectrophoresis (DEP) and AC electrothermal (ACET) effects, so as to realize in-situ enrichment of macro and ...


Characterization And Performance Of Algal Biofilms For Wastewater Treatment And Industrial Applications, Maureen Kesaano 2015 Utah State University

Characterization And Performance Of Algal Biofilms For Wastewater Treatment And Industrial Applications, Maureen Kesaano

All Graduate Theses and Dissertations

This study was carried out on algal biofilms grown using rotating algal biofilm reactors (RABRs) with the aim of: i) characterizing their growth in terms of photosynthetic activity and morphology ii) evaluating their performance as a wastewater treatment option and a feedstock for biofuels production, and iii) examining the algal-bacteria interactions.

A review of algal biofilm technologies currently employed in wastewater treatment processes was made to compare nutrient removal efficiencies, factors that influenced algal biofilm growth, and the different bioproducts generated from algal biomass. Consequently, research efforts were directed towards addressing pertinent issues identified in literature in order to optimize ...


Safety And Efficacy Results Of Switch From Imiglucerase To Velaglucerase Alfa Treatment In Patients With Type 1 Gaucher Disease, Deborah Elstein, Atul Mehta, Derralynn A. Hughes, Pilar Giraldo, Joel Charrow, Laurie Smith, Suma P. Shankar, Thomas N. Hangartner, Yune Kunes, Nan Wang, Eric Crombez, Ari Zimran 2015 Wright State University - Main Campus

Safety And Efficacy Results Of Switch From Imiglucerase To Velaglucerase Alfa Treatment In Patients With Type 1 Gaucher Disease, Deborah Elstein, Atul Mehta, Derralynn A. Hughes, Pilar Giraldo, Joel Charrow, Laurie Smith, Suma P. Shankar, Thomas N. Hangartner, Yune Kunes, Nan Wang, Eric Crombez, Ari Zimran

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Gaucher disease (GD) is a lysosomal storage disorder; symptomatic patients with type 1 GD need long-term disease-specific therapy of which the standard of care has been enzyme replacement therapy (ERT). Thirty-eight of 40 patients (aged 9–71 years) clinically stable on ERT with imiglucerase, safely switched to a comparable dose of velaglucerase alfa (units/kg) during TKT034, a 12-month, open-label clinical study, and for 10–50 months in an extension study. The most common adverse events (AEs) judged to be drug-related in the extension were fatigue and bone pain. No drug-related serious AEs were reported. No AEs led to study ...


Velaglucerase Alfa (Vpriv) Enzyme Replacement Therapy In Patients With Gaucher Disease: Long-Term Data From Phase Iii Clinical Trials, Derralynn A. Hughes, Derlis Gonzalez, Elena A. Lukina, Atul Mehta, Madhulika Kabra, Deborah Elstein, Isaac Kisinovsky, Pilar Giraldo, Ashish Bavdekar, Thomas N. Hangartner, Nan Wang, Eric Crombez, Ari Zimran 2015 Wright State University - Main Campus

Velaglucerase Alfa (Vpriv) Enzyme Replacement Therapy In Patients With Gaucher Disease: Long-Term Data From Phase Iii Clinical Trials, Derralynn A. Hughes, Derlis Gonzalez, Elena A. Lukina, Atul Mehta, Madhulika Kabra, Deborah Elstein, Isaac Kisinovsky, Pilar Giraldo, Ashish Bavdekar, Thomas N. Hangartner, Nan Wang, Eric Crombez, Ari Zimran

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Type 1 Gaucher disease is an inherited lysosomal enzyme deficiency with variable age of symptom onset. Common presenting signs include thrombocytopenia, anemia, hepatosplenomegaly, bone abnormalities, and, additionally in children, growth failure. Fifty-seven patients aged 3–62 years at the baseline of two phase III trials for velaglucerase alfa treatment were enrolled in the single extension study. In the extension, they received every-other-week velaglucerase alfa intravenous infusions for 1.2–4.8 years at 60 U/kg, although 10 patients experienced dose reduction. No patient experienced a drug-related serious adverse event or withdrew due to an adverse event. One patient died ...


Nanosecond Pulse Electric Field Activated-Platelet Rich Plasma Enhances The Return Of Blood Flow To Large And Ischemic Wounds In A Rabbit Model, Barbara Y. Hargrave, Francis Li 2015 Old Dominion University

Nanosecond Pulse Electric Field Activated-Platelet Rich Plasma Enhances The Return Of Blood Flow To Large And Ischemic Wounds In A Rabbit Model, Barbara Y. Hargrave, Francis Li

Bioelectrics Publications

Platelet-rich plasma is a therapeutic strategy used for accelerating wound healing of a wide range of tissues through the release of platelet growth factors. Here, we describe a nonchemical, safe method for preparing platelet-rich plasma using nanosecond-pulsed electric fields (nsPEFs) and investigated the effect of this platelet-rich plasma on reperfusion of blood in large skin flap or ischemic hind limb wounds in New Zealand White rabbits. Laser Doppler images of blood flow to the dorsal surface of skin flap wounds or to ischemic hind limb wounds were obtained from wounds treated with 0.9% saline or nanosecond-pulsed electric field prepared ...


Immunization Of Mice With Anthrax Protective Antigen Limits Cardiotoxicity But Not Hepatotoxicity Following Lethal Toxin Challenge, T. Scott Devera, Dawn K. Prusator, Sunil K. Joshi, Jimmy D. Ballard, Mark L. Lang 2015 Old Dominion University

Immunization Of Mice With Anthrax Protective Antigen Limits Cardiotoxicity But Not Hepatotoxicity Following Lethal Toxin Challenge, T. Scott Devera, Dawn K. Prusator, Sunil K. Joshi, Jimmy D. Ballard, Mark L. Lang

Bioelectrics Publications

Protective immunity against anthrax is inferred from measurement of vaccine antigen-specific neutralizing antibody titers in serum samples. In animal models, in vivo challenges with toxin and/or spores can also be performed. However, neither of these approaches considers toxin-induced damage to specific organ systems. It is therefore important to determine to what extent anthrax vaccines and existing or candidate adjuvants can provide organ-specific protection against intoxication. We therefore compared the ability of Alum, CpG DNA and the CD1d ligand alpha-galactosylceramide (alphaGC) to enhance protective antigen-specific antibody titers, to protect mice against challenge with lethal toxin, and to block cardiotoxicity and ...


In Situ Oh Generation From O2 And H2o2 Plays A Critical Role In Plasma-Induced Cell Death, Dehui Xu, Dingxing Liu, Biqing Wang, Chen Chen, Zeyu Chen, Dong Li, Yanjie Yang, Hailan Chen, Michael G. Kong 2015 Old Dominion University

In Situ Oh Generation From O2 And H2o2 Plays A Critical Role In Plasma-Induced Cell Death, Dehui Xu, Dingxing Liu, Biqing Wang, Chen Chen, Zeyu Chen, Dong Li, Yanjie Yang, Hailan Chen, Michael G. Kong

Bioelectrics Publications

Reactive oxygen and nitrogen species produced by cold atmospheric plasma (CAP) are considered to be the most important species for biomedical applications, including cancer treatment. However, it is not known which species exert the greatest biological effects, and the nature of their interactions with tumor cells remains ill-defined. These questions were addressed in the present study by exposing human mesenchymal stromal and LP-1 cells to reactive oxygen and nitrogen species produced by CAP and evaluating cell viability. Superoxide anion (O2-) and hydrogen peroxide (H2O2) were the two major species present in plasma, but their respective concentrations were not sufficient to ...


Transcatheter Heart Valve Subassembly Device, Adam Aslam, Matthew Bezkrovny, Daniel DeGree 2015 California Polytechnic State University - San Luis Obispo

Transcatheter Heart Valve Subassembly Device, Adam Aslam, Matthew Bezkrovny, Daniel Degree

Mechanical Engineering

No abstract provided.


Sapien3 Comb Stitch Improvement For Edwards Lifesciences, William Harley, Thomas Pluschkell, John McTigue, Garrett Reed 2015 California Polytechnic State University - San Luis Obispo

Sapien3 Comb Stitch Improvement For Edwards Lifesciences, William Harley, Thomas Pluschkell, John Mctigue, Garrett Reed

Mechanical Engineering

The complete senior project report was submitted to the project advisor and sponsor. The results of this project are of a confidential nature and will not be published at this time.


Renal Artery Stent Fatigue Test, Braden Cooper, Munir Eltal, Jennifer Hawthorne, Ashley Schaefer 2015 California Polytechnic State University - San Luis Obispo

Renal Artery Stent Fatigue Test, Braden Cooper, Munir Eltal, Jennifer Hawthorne, Ashley Schaefer

Mechanical Engineering

In today’s world of medical innovation, regulations and requirements set by organizations such as the Food and Drug Administration (FDA), the International Organization for Standardization (ISO), and ASTM International (American Society for Testing and Materials) can inhibit rapid innovation by demanding rigorous testing of new designs. For arterial stents, the standard is that each design must be tested to simulate 10 years of life in an environment congruent to an in vivo environment. Endologix in Irvine, California develops and manufactures minimally invasive treatments for aortic diseases, with a focus on stent grafts for the treatment of abdominal aortic aneurysms ...


Multiphysics Modeling To Enhance Understanding Of Microwave Heating Of Food In Domestic Ovens, Jiajia Chen 2015 University of Nebraska-Lincoln

Multiphysics Modeling To Enhance Understanding Of Microwave Heating Of Food In Domestic Ovens, Jiajia Chen

Biological Systems Engineering--Dissertations, Theses, and Student Research

Nonuniform heating is the biggest issue in the microwave heating of prepared meals. Multiphysics based models are promising tools to improve microwave heating uniformity by properly designing the food product. However, limited availability of accurate temperature-dependent material properties, inadequate model prediction accuracy, and high computational power and complexity in model development are three gaps that greatly limited the application of these models in the food industry.

To fill in the gaps, firstly, we developed a multitemperature calibration protocol to measure temperature-dependent dielectric properties (dielectric constant and loss factor). The temperature-dependent dielectric and thermal (thermal conductivity and specific heat capacity) properties ...


A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device, Taylor Davis 2015 California Polytechnic State University - San Luis Obispo

A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device, Taylor Davis

Biomedical Eng/General Eng.

The company G-Force CRC LLC is currently experiencing the dichotomy of the FDA's conflicting role right now as they begin to approach FDA approval. G-Force CRC LLC is a small medical device company headquartered in San Diego, CA. The owner of the company, Dr. Ian Purcell, is an Otoneurologist apart of Alvarado Hospital. His medical practice mainly deals with patients who have balance disorders and therefore the devices that he has developed over the last 6+ years are primarily used to assist in the diagnosis of those balance disorders. G-Force CRC LLC was officially created in the summer of ...


Computational Fluid Dynamics Applied To The Analysis Of Blood Flow Through Central Aortic To Pulmonary Artery Shunts, Carey Celestin Jr 2015 University of New Orleans

Computational Fluid Dynamics Applied To The Analysis Of Blood Flow Through Central Aortic To Pulmonary Artery Shunts, Carey Celestin Jr

University of New Orleans Theses and Dissertations

This research utilizes CFD to analyze blood flow through pathways representative of central shunts, commonly used as part of the Fontan procedure to treat cyanotic heart disease. In the first part of this research, a parametric study of steady, Newtonian blood flow through parabolic pathways was performed to demonstrate the effect that flow pathway curvature has on wall shear stress distribution and flow energy losses. In the second part, blood flow through two shunts obtained via biplane angiograms is simulated. Pressure boundary conditions were obtained via catheterization. Results showed that wall shear stresses were of sufficient magnitude to initiate platelet ...


Biosensing Enhancement Of Dengue Virus Using Microballoon Mixers On Centrifugal Microfluidic Platforms, 2015 SelectedWorks

Biosensing Enhancement Of Dengue Virus Using Microballoon Mixers On Centrifugal Microfluidic Platforms

Faculty of Engineering University of Malaya

Dengue is the current leading cause of death among children in several Latin American and Asian countries. Due to poverty in areas where the disease is prevalent and the high cost of conventional diagnostic systems, low cost devices are needed to reduce the burden caused by dengue infection. Centrifugal microfluidic platforms are an alternative solution to reduce costs and increase the availability of a rapid diagnostic system. The rate of chemical reactions in such devices often depends on the efficiency of the mixing techniques employed in their microfluidic networks. This paper introduces a micromixer that operates by the expansion and ...


Gold Nanostructures For Sensing And Functional Bioimaging, Maximilian Y. Fei 2015 Washington University in St Louis

Gold Nanostructures For Sensing And Functional Bioimaging, Maximilian Y. Fei

Engineering and Applied Science Theses & Dissertations

Gold nanostructures offer an extremely promising path forward in the fields of imaging and sensing because of their unique optical and chemical properties. Here, we demonstrate that plasmonic nanostructures can be employed as nanoscale transducers to monitor the growth and phase transitions in ultrathin polymer films. In particular, gold nanorods with high refractive index sensitivity (~150 nm / refractive index unit (RIU)) were employed to probe the growth and swelling of polyelectrolyte multilayers (PEM). By comparing the wavelength shift and extinction intensity of the localized surface plasmon resonance (LSPR) of the gold nanorods coated with PEM in air and water, the ...


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