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Novel Platform Development Using An Assembly Of Carbon Nanotube, Nanogold And Immobilized Rna Capture Element Towards Rapid, Selective Sensing Of Bacteria, Elizabeth I. Maurer, Kristen K. Comfort, Saber M. Hussain, John J. Schlager, Sharmila M. Mukhopadhyay 2016 Wright State University - Main Campus

Novel Platform Development Using An Assembly Of Carbon Nanotube, Nanogold And Immobilized Rna Capture Element Towards Rapid, Selective Sensing Of Bacteria, Elizabeth I. Maurer, Kristen K. Comfort, Saber M. Hussain, John J. Schlager, Sharmila M. Mukhopadhyay

Sharmila M. Mukhopadhyay

This study examines the creation of a nano-featured biosensor platform designed for the rapid and selective detection of the bacterium Escherichia coli. The foundation of this sensor is carbon nanotubes decorated with gold nanoparticles that are modified with a specific, surface adherent ribonucleic acid (RNA) sequence element. The multi-step sensor assembly was accomplished by growing carbon nanotubes on a graphite substrate, the direct synthesis of gold nanoparticles on the nanotube surface, and the attachment of thiolated RNA to the bound nanoparticles.

The application of the compounded nanomaterials for sensor development has the distinct advantage of retaining the electrical behavior property ...


Somatic Stimulation Causes Frontoparietal Cortical Changes In Neonates: A Functional Near-Infrared Spectroscopy Study, Nasser H. Kashou, Irfaan Akram Dar, Kathryn Hasenstab, Ramzi W. Nahhas, Sudarshan R. Jadcherla 2016 Wright State University - Main Campus

Somatic Stimulation Causes Frontoparietal Cortical Changes In Neonates: A Functional Near-Infrared Spectroscopy Study, Nasser H. Kashou, Irfaan Akram Dar, Kathryn Hasenstab, Ramzi W. Nahhas, Sudarshan R. Jadcherla

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Palmar and plantar grasp are the foremost primitive neonatal reflexes and functions. Persistence of these reflexes in infancy is a sign of evolving cerebral palsy. Our aims were to establish measurement feasibility in a clinical setting and to characterize changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbD) concentration in the bilateral frontoparietal cortex in unsedated neonates at the crib-side using functional near-infrared spectroscopy (fNIRS). We hypothesized that bilateral concentration changes will occur upon somatic central and peripheral somatic stimulation. Thirteen preterm neonates (five males) underwent time 1, and six (two males) returned for time 2 (mean PMA ¼ 41.6 and ...


Modeling Effective Connectivity In High-Dimensional Cortical Source Signals, Yuxiao Wang, Chee-Ming Ting PhD, Hernando Ombao 2016 University of California, Irvine

Modeling Effective Connectivity In High-Dimensional Cortical Source Signals, Yuxiao Wang, Chee-Ming Ting Phd, Hernando Ombao

Chee-Ming Ting PhD

To study effective connectivity among sources in a densely voxelated (high-dimensional) cortical surface, we develop the source-space factor VAR model. The first step in our procedure is to estimate cortical activity from multichannel electroencephalograms (EEG) using anatomically constrained brain imaging methods. Following parcellation of the cortical surface into disjoint regions of interest (ROIs), latent factors within each ROI are computed using principal component analysis. These factors are ROI-specific low-rank approximations (or representations) which allow for efficient estimation of connectivity in the high-dimensional cortical source space. The second step is to model effective connectivity between ROIs by fitting a VAR model ...


A Study On Biocompatibility Of Carbon Nanoparticles In Hela Cells Dictated By Synthesis And Sterilization, Elisa Panzarini, Cristian Vergallo, Stefania Mariano 2016 University of Salento

A Study On Biocompatibility Of Carbon Nanoparticles In Hela Cells Dictated By Synthesis And Sterilization, Elisa Panzarini, Cristian Vergallo, Stefania Mariano

Kevin Lee

Due to their unique chemical and physical properties, carbon-based NanoMaterials (C-NMs) are largely exploited in biomedicine, i.e., cell and tissue imaging, drug delivery and tissue engineering scaffold, even if reports regarding their toxicity are still conflicting. In fact, biological effects strictly depend on the dynamic physicochemical characteristics of C-NMs, which in turn are strongly influenced by the procedures of their synthesis, and nanometrological techniques, e.g., Electron Microscopy (EM)-based analysis, are becoming the main tool for researchers to characterize nanoproducts. The aim of the present work is the study of the influence of synthesis and sterilization protocols on ...


Optimization Of The Design Of An Amphiphilic Biodegradable Polymer For Tissue-Engineering Application, Ben Zhang, Tera M. Filion, Jie Song 2016 University of Massachusetts Medical School

Optimization Of The Design Of An Amphiphilic Biodegradable Polymer For Tissue-Engineering Application, Ben Zhang, Tera M. Filion, Jie Song

Jie Song

Biodegradable polymers have been widely utilized as drug delivery vehicles and tissue engineering scaffolds. We previously designed amphiphilic triblock copolymer poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) (PELA) and its hydroxyapatite (HA) composites for bone tissue engineering applications. The hydrophilic electrospun PELA-HA composite exhibited aqueous stability and elastic handling characteristics, and was able to template the proliferation and osteogenesis of bone marrow stromal cells (BMSCs) in vitro and in vivo when spiral-wrapped into cylinders and press-fit into critical size femoral segmental defects in rats. However, the slow degradation of PELA has prevented timely disappearance of the scaffold and ...


Microscale Investigation Of Thermo-Fluid Transport In The Transition Fil, Region Of An Evaporating Capillary Meniscus Using A Microgravity Environment, Kenneth D. Kihm, Jeffrey S. Allen, Kevin P. Hallinan, David M. Pratt 2016 University of Tennessee, Knoxville

Microscale Investigation Of Thermo-Fluid Transport In The Transition Fil, Region Of An Evaporating Capillary Meniscus Using A Microgravity Environment, Kenneth D. Kihm, Jeffrey S. Allen, Kevin P. Hallinan, David M. Pratt

Kevin Hallinan

In order to enhance the fundamental understanding of thin film evaporation and thereby improve the critical design concept for two-phase heat transfer devices, microscale heat and mass transport is to be investigated for the transition film region using state-of-the-art optical diagnostic techniques. By utilizing a microgravity environment, the length scales of the transition film region can be extended sufficiently, from submicron to micron, to probe and measure the microscale transport fields which are affected by intermolecular forces. Extension of the thin film dimensions under microgravity will be achieved by using a conical evaporator made of a thin silicon substrate under ...


Nanocharacterization Of Bio-Silica Using Atomic Force And Ultrasonic Force Microscopy, Vinaypreet S. Gill, Kevin P. Hallinan, N. S. Brar 2016 Brown University

Nanocharacterization Of Bio-Silica Using Atomic Force And Ultrasonic Force Microscopy, Vinaypreet S. Gill, Kevin P. Hallinan, N. S. Brar

Kevin Hallinan

Nanotechnology has become central to our research efforts to fabricate relatively smaller size devices, which are more versatile than their older and larger predecessors. Silica is a very important material in this regard. Recently, a new biomimetically inspired path to silica production has been demonstrated. This processing technique was inspired from biological organisms, such as marine diatoms, which produce silica at ambient conditions and almost neutral ph with beautiful control over location and structure. Recently, several researchers have demonstrated that positional control of silica formed could be achieved by application of an electric field to locate charged enzymes responsible for ...


Leveraging Students’ Passion And Creativity: Ethos At The University Of Dayton, Margaret Pinnell, Malcolm Daniels, Kevin P. Hallinan, Gretchen Berkemeier 2016 University of Dayton

Leveraging Students’ Passion And Creativity: Ethos At The University Of Dayton, Margaret Pinnell, Malcolm Daniels, Kevin P. Hallinan, Gretchen Berkemeier

Kevin Hallinan

The Engineers in Technical Humanitarian Opportunities of Service-learning (ETHOS) program was developed in the spring of 2001 by an interdisciplinary group (electrical, chemical, civil and mechanical) of undergraduate engineering students at the University of Dayton (UD). ETHOS was founded on the belief that engineers are more apt and capable to appropriately serve our world if they have an understanding of technology’s global linkage with values, culture, society, politics, and the economy. Since 2001, the ETHOS program at UD has grown and changed.

From conceptualization, to implementation, to maturation and national recognition, the program has addressed challenges of academic acceptance ...


Industrial Solid-State Energy Harvesting: Mechanisms And Examples, Matthew Kocoloski, Carl Eger, Robin McCarty, Kevin P. Hallinan, J. Kelly Kissock 2016 Carnegie Mellon University

Industrial Solid-State Energy Harvesting: Mechanisms And Examples, Matthew Kocoloski, Carl Eger, Robin Mccarty, Kevin P. Hallinan, J. Kelly Kissock

Kevin Hallinan

This paper explores the potential for solid-state energy harvesting in industrial applications. In contrast to traditional heat recovery, the output of solid-state devices is electricity, which can be readily used in virtually any plant. The progress in harvesting waste heat via thermoelectric and thermionic generators is described. With second law efficiencies now approaching 50% and 80% respectively, we show that these technologies are on the cusp of practical use. Finally, we present an example of energy harvesting using thermionic devices in an industrial application. The example considers energy harvesting from a furnace at a glass manufacturing facility where exhaust gases ...


Energy Information Augmented Community-Based Energy Reduction, Kevin P. Hallinan, Harvey Enns, Stephenie Ritchey, Phil Brodrick, Nathan Lammers, Nichole Hanus, Mark Rembert, Tony Rainsberger 2016 University of Dayton

Energy Information Augmented Community-Based Energy Reduction, Kevin P. Hallinan, Harvey Enns, Stephenie Ritchey, Phil Brodrick, Nathan Lammers, Nichole Hanus, Mark Rembert, Tony Rainsberger

Kevin Hallinan

More than one-half of all U.S. states have instituted energy efficiency mandates requiring utilities to reduce energy use. To achieve these goals, utilities have been permitted rate structures to help them incentivize energy reduction projects. This strategy is proving to be only modestly successful in stemming energy consumption growth. By the same token, community energy reduction programs have achieved moderate to very significant energy reduction. The research described here offers an important tool to strengthen the community energy reduction efforts—by providing such efforts energy information tailored to the energy use patterns of each building occupant. The information provided ...


Clean Energy Infrastructure Educational Initiative, Kevin P. Hallinan, James A. Menart, Robert Gilbert 2016 University of Dayton

Clean Energy Infrastructure Educational Initiative, Kevin P. Hallinan, James A. Menart, Robert Gilbert

Kevin Hallinan

The Clean Energy Infrastructure Educational Initiative represents a collaborative effort by the University of Dayton, Wright State University and Sinclair Community College. This effort above all aimed to establish energy related programs at each of the universities while also providing outreach to the local, state-wide, and national communities. At the University of Dayton, the grant has aimed at: solidfying a newly created Master's program in Renewable and Clean Energy; helping to establish and staff a regional sustainability organization for SW Ohio. As well, as the prime grantee, the University of Dayton was responsible for ensuring curricular sharing between WSU ...


A Study Of The Fundamental Operations Of A Capillary Driven Heat Transfer Device In Both Normal And Low Gravity Part 1-Liquid Slug Formation In Low Gravity, Jeffrey S. Allen, Kevin P. Hallinan, Jack Lekan 2016 NASA Glenn Research Center

A Study Of The Fundamental Operations Of A Capillary Driven Heat Transfer Device In Both Normal And Low Gravity Part 1-Liquid Slug Formation In Low Gravity, Jeffrey S. Allen, Kevin P. Hallinan, Jack Lekan

Kevin Hallinan

Research has been conducted to observe the operation of a capillary pumped loop (CPL) in both normal and low gravity environments in order to ascertain the causes of device failure. The failures of capillary pumped heat transport devices in low gravity; specifically; evaporator dryout, are not understood and the available data for analyzing the failures is incomplete.

To observe failure in these devices an idealized experimental CPL was configured for testing in both a normal-gravity and a low-gravity environment. The experimental test loop was constructed completely of Pyrex tubing to allow for visualization of system operations. Heat was added to ...


Differential Association Of Vitronectin And Fibronectin With Glass And Electrospun Fibers Of A Poly (D-Lysine) /Poly (Acrylic Acid), Syed Muhammad Sohaib Zafar Zafar 2016 University of South Florida

Differential Association Of Vitronectin And Fibronectin With Glass And Electrospun Fibers Of A Poly (D-Lysine) /Poly (Acrylic Acid), Syed Muhammad Sohaib Zafar Zafar

Graduate Theses and Dissertations

Proteins represent major constituent of the extracellular matrix which plays an important role in the formation, maintenance and remodeling of tissues, this project focuses on adsorption of two specific serum proteins fibronectin (FN) and vitronectin (VTN) responsible for mediating cell matrix interaction through integrin binding, tripeptide Arg-Gly-Asp (RGD) sequence found in these protein features are recognized by αβV3 integrin which ultimately helps in clot formation.


Phylogenetic And Experimental Characterization Of An Acyl-Acp Thioesterase Family Reveals Significant Diversity In Enzymatic Specificity And Activity, Fuyuan Jing, David C. Cantu, Jarmila Tvaruzkova, Jay P. Chipman, Basil J. Nikolau, Marna D. Yandeau-Nelson, Peter J. Reilly 2016 Iowa State University

Phylogenetic And Experimental Characterization Of An Acyl-Acp Thioesterase Family Reveals Significant Diversity In Enzymatic Specificity And Activity, Fuyuan Jing, David C. Cantu, Jarmila Tvaruzkova, Jay P. Chipman, Basil J. Nikolau, Marna D. Yandeau-Nelson, Peter J. Reilly

Basil Nikolau

Background: Acyl-acyl carrier protein thioesterases (acyl-ACP TEs) catalyze the hydrolysis of the thioester bond that links the acyl chain to the sulfhydryl group of the phosphopantetheine prosthetic group of ACP. This reaction terminates acyl chain elongation of fatty acid biosynthesis, and in plant seeds it is the biochemical determinant of the fatty acid compositions of storage lipids.

Results: To explore acyl-ACP TE diversity and to identify novel acyl ACP-TEs, 31 acyl-ACP TEs from wide-ranging phylogenetic sources were characterized to ascertain their in vivo activities and substrate specificities. These acylACP TEs were chosen by two different approaches: 1) 24 TEs were ...


Combining Real-Time Fmri Neurofeedback Training Of The Dlpfc With N-Back Practice Results In Neuroplastic Effects Confined To The Neurofeedback Target Region, Matthew Sherwood, Michael Patrick Weisend Ph.D., Jessica Kane, Jason G. Parker 2016 Wright State University - Main Campus

Combining Real-Time Fmri Neurofeedback Training Of The Dlpfc With N-Back Practice Results In Neuroplastic Effects Confined To The Neurofeedback Target Region, Matthew Sherwood, Michael Patrick Weisend Ph.D., Jessica Kane, Jason G. Parker

Matthew Sherwood

In traditional fMRI, individuals respond to exogenous stimuli and are naïve to the effects of the stimuli on their neural activity patterns. Changes arising in the fMRI signal are analyzed post-hoc to elucidate the spatial and temporal activation of brain regions associated with the tasks performed. The advent of real-time fMRI has enabled a new method to systematically alter brain activity across space and time using neurofeedback training (NFT), providing a new tool to study internally-driven processes such as neuroplasticity. In this work, we combined n-back practice with fMRI-NFT of the left dorsolateral prefrontal cortex (DLPFC) to better understand ...


The Development Of A Prosthetic Training Software For Upper Limb Amputees, Tyler Kayne Sullins 2016 University of South Florida

The Development Of A Prosthetic Training Software For Upper Limb Amputees, Tyler Kayne Sullins

Graduate Theses and Dissertations

The purpose of this study was to develop an intuitive software that aids in the field of prosthetic training and rehabilitation by creating an individualized visualization of joint angles. This software is titled “the prosthetic training software (PTS) for individualized joint angle representation”, and it enables the individualized portrayal of predicted or pre-recorded joint angles. The PTS is an intuitive program for clinicians and prosthesis users that produces an animation of a virtual avatar reflecting the user’s segment lengths and amputation for rehabilitation and training purposes.

The PTS consists of a graphical user interface (GUI) and a 3D visualization ...


Intracranial Pressure Sensor, Matthew Murray, Jared Shimada 2016 Santa Clara University

Intracranial Pressure Sensor, Matthew Murray, Jared Shimada

Bioengineering Senior Theses

Idiopathic Intracranial Hypertension (IIH) also known as Pseudotumor Cerebri is a condition resulting from an increase of Cerebrospinal Fluid (CSF), a fluid that helps to protect the brain and spinal cord, in the cranial cavity. Currently the only treatment method for this health condition is the draining of the fluid via implanted intracranial shunts that get clogged in approximately 50% of patients. Clogged shunts can only be detected when IIH symptoms begin to reappear. We propose to create an ultrasound-read intracranial pressure sensor used to supplement shunts implanted in patients who suffer from Idiopathic Intracranial Hypertension. This will provide immediate ...


Preclinical Study For Targeted Breast Cancer Therapy, Katie Bond, Lauren McCormick, Jordan Karroll 2016 Santa Clara University

Preclinical Study For Targeted Breast Cancer Therapy, Katie Bond, Lauren Mccormick, Jordan Karroll

Bioengineering Senior Theses

Cancer is a devastating disease which affects millions. For this reason, many scientists are working to develop drugs that can specifically target cancer cells within the body. Preclinical trials are an important phase in the drug development process, as they allow scientists to determine whether or not a drug candidate may be viable for human use. Targeted therapies can be achieved by using monoclonal antibodies as well as small molecule drugs. In this study we compared the effects of two control monoclonal antibody drugs, “mAb1” and “mAb2,” with one small molecule drug, “Drug S,” on the MDAMB231 human breast cancer ...


Suture Passing Device For Hyoid Susupension In Sleep Apnea Surgery, Corbin Craven, Nicholas Leavengood, Solomon Mulugeta 2016 Santa Clara University

Suture Passing Device For Hyoid Susupension In Sleep Apnea Surgery, Corbin Craven, Nicholas Leavengood, Solomon Mulugeta

Bioengineering Senior Theses

Obstructive Sleep Apnea (OSA) is a condition which is characterized by momentary pauses in a person’s breathing while they are sleeping. Current treatment options for sleep apnea include CPAP, oral appliances, and surgery. Of these options, hyoid suspension surgery is one of the most effective, but is significantly underutilized. This is due to the fact that performing hyoid suspension surgery by current methods is complicated and can be painful for the patient. As our senior design project, we designed and prototyped a novel medical device that facilitates fast, easy, and consistent hyoid suspension surgery. Through functional testing of our ...


Bolstering The Cell Membrane Of S. Cerevisiae For Efficient Bioethanol Production From Lignocellulosic Biomass, Conary Meyer, Matt Kubit 2016 Santa Clara University

Bolstering The Cell Membrane Of S. Cerevisiae For Efficient Bioethanol Production From Lignocellulosic Biomass, Conary Meyer, Matt Kubit

Bioengineering Senior Theses

With the need for alternatives to fossil fuels becoming more prevalent, biofuels has become an increasingly attractive alternative. Traditional biofuel production was quickly halted as a result of its ethical complications, leading to the development of secondgeneration biofuels. This system utilizes plant waste instead of food as its starting material, allowing for rapid recycling of this widely available and cheap carbon source. This switch was, however, coupled with complications. Of those, the most prominent is the inevitable release of acetic acid resulting from the breakdown of the lignocellulosic waste. This acetic acid is challenging to neutralize or extract in a ...


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