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Monitoring Of Pseudomonas Aeruginosa Toxins Via Miniaturized Electrochemical Assemblies, Thaddaeus Webster 2015 Northeastern University

Monitoring Of Pseudomonas Aeruginosa Toxins Via Miniaturized Electrochemical Assemblies, Thaddaeus Webster

Chemical Engineering Dissertations

The production of pyocyanin from the opportunistic pathogen Pseudomonas aeruginosa was probed using a variety of miniaturized electrochemical systems. Goal 1 used disposable screen printed carbon electrodes to measure pyocyanin in medically relevant samples showing for the first time that pyocyanin can be detected at medically relevant concentrations (1-100 µM) without sample processing. Goal 2 coupled these same electrodes with Polydimethylsiloxane growth chambers to expose P. aeruginosa biofilms to varying concentrations of colistin sulphate. A reduction in electrochemical signal from pyocyanin, of approximately 80% when exposed to 100 mg/L colistin sulphate, highlights this molecules relation to biofilm health. Goal ...


Gold Nanostructures For Sensing And Functional Bioimaging, Maximilian Y. Fei 2015 Washington University in St Louis

Gold Nanostructures For Sensing And Functional Bioimaging, Maximilian Y. Fei

Engineering and Applied Science Theses & Dissertations

Gold nanostructures offer an extremely promising path forward in the fields of imaging and sensing because of their unique optical and chemical properties. Here, we demonstrate that plasmonic nanostructures can be employed as nanoscale transducers to monitor the growth and phase transitions in ultrathin polymer films. In particular, gold nanorods with high refractive index sensitivity (~150 nm / refractive index unit (RIU)) were employed to probe the growth and swelling of polyelectrolyte multilayers (PEM). By comparing the wavelength shift and extinction intensity of the localized surface plasmon resonance (LSPR) of the gold nanorods coated with PEM in air and water, the ...


Regional Anesthesiology Ultrasound-Guided Nerve Block Simulator, Avik Purkayastha, David Call, Mehdi Zare, Michael Fister 2015 University of Tennessee, Knoxville

Regional Anesthesiology Ultrasound-Guided Nerve Block Simulator, Avik Purkayastha, David Call, Mehdi Zare, Michael Fister

Biomedical and Diagnostic Sciences Publications and Other Works

The purpose of the model is to allow residents in anesthesiology to practice the ultrasound guided supraclavicular nerve block procedure without having to practice on an actual patient so that they can hone their skills before performing the actual procedure. Our goals when creating the device were having a life-like feel, having the model be anatomically correct, and having the model provide an accurate ultrasound. After 3 iterations we were able to satisfy all 3 requirements but the most accurate ultrasound was provided by the second model, which did we believed did not satisfy the other requirements well enough. For ...


A Space-Variant Model For Motion Interpretation Across The Visual Field, Guido Maiello, Manuela Chessa, Peter J. Bex, Fabio Solari 2015 University College London

A Space-Variant Model For Motion Interpretation Across The Visual Field, Guido Maiello, Manuela Chessa, Peter J. Bex, Fabio Solari

MODVIS Workshop

We implement a neural model for the estimation of the focus of radial motion (FRM) at different retinal locations and we assess the model by comparing its results with respect to the precision with which human observers can estimate the FRM in naturalistic, moving dead leaves stimuli. The proposed neural model describes the deep hierarchy of the first stages of the dorsal visual pathway [Solari et al., 2014]. Such a model is space-variant, since it takes into account the retino-cortical transformation of the primate visual system through log-polar mapping that produces a cortical representation of the visual signal to the ...


3d Printing In Healthcare, Caleb Branch 2015 St. John Fisher College

3d Printing In Healthcare, Caleb Branch

Undergraduate Review: A Journal of Undergraduate Student Research

Technology is everywhere. Technology surrounds every aspect of 21st century life. It is in the cell phones we use, the cars we drive, and even the food we eat. A large portion of modern technology used is taken for granted and overlooked. Despite this, some technology fields continue to grow. Biomedical engineering, specifically 3D printing’s applications to healthcare, has been often overlooked until. Regardless of its status in the mainstream, 3D printing is prosperous in healthcare and its future looks bright. This piece analyzes 3D printing in healthcare. It hones in on the finer details of each specific ...


Fiber Optic Bandage, Logan McNeil 2015 University of Tennessee, Knoxville

Fiber Optic Bandage, Logan Mcneil

University of Tennessee Honors Thesis Projects

No abstract provided.


Ultrasound-Guided Regional Anesthesia Nerve Block Simulator, Avik Purkayastha, David Call, Alex Zare, Michael Fister 2015 University of Tennessee, Knoxville

Ultrasound-Guided Regional Anesthesia Nerve Block Simulator, Avik Purkayastha, David Call, Alex Zare, Michael Fister

University of Tennessee Honors Thesis Projects

No abstract provided.


Mitochondrial Dysfunction And Loss Of Glutamate Uptake In Primary Astrocytes Exposed To Titanium Dioxide Nanoparticles, Christina L. Wilson 2015 University of Nebraska-Lincoln

Mitochondrial Dysfunction And Loss Of Glutamate Uptake In Primary Astrocytes Exposed To Titanium Dioxide Nanoparticles, Christina L. Wilson

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

The proper function of astrocytes is critical for brain health as they are the most abundant cells in the brain which monitor ion homeostasis, recycle neurotransmitters and respond to tissue damage therefore disruption in astrocyte function can result in overall detrimental effects and has been linked with neurodegenerative diseases. Titanium Dioxide (TiO2) nanoparticles are currently the second most produced engineered nanomaterial in the world with vast usage in consumer products leading to recurrent human exposure. Animal studies indicate significant nanoparticle accumulation in the brain while cellular toxicity studies demonstrate negative effects on neuronal cell viability and function. However, the ...


Vcare: A Personal Emergency Response System To Promote Safe And Independent Living Among Elders Staying By Themselves In Community Or Residential Settings, Priyankar Bhattacharjee 2015 University of Nebraska-Lincoln

Vcare: A Personal Emergency Response System To Promote Safe And Independent Living Among Elders Staying By Themselves In Community Or Residential Settings, Priyankar Bhattacharjee

Dissertations & Student Research in Computer Electronics & Engineering

‘Population aging’ is a growing concern for most of us living in the twenty first century, primarily because many of us in the next few years will have a senior person to care for - spending money towards their healthcare expenditures AND/OR having to balance a full-time job with the responsibility of care-giving, travelling from another city to be with this elderly citizen who might be our parent, grand-parent or even community elders. As informal care-givers, if somehow we were able to monitor the day-to-day activities of our elderly dependents, and be alerted when wrong happens to them that would ...


Electrospinning Of Polycaprolactone Core-Shell Nanofibers With Anti-Cancer Drug, Sakib Iqbal, Mujibur Khan, Saheem Absar, Andrew Diamanduros, Samuel Chambers 2015 Georgia Southern University

Electrospinning Of Polycaprolactone Core-Shell Nanofibers With Anti-Cancer Drug, Sakib Iqbal, Mujibur Khan, Saheem Absar, Andrew Diamanduros, Samuel Chambers

Georgia Southern University Research Symposium

Encapsulation of a model anti-cancer drug, 5-Fluorouracul (5-FU) into biocompatible core-shell nanofibers of polycaprolactone (PCL) nanofibers was fabricated using a coaxial electrospinning process. Our work aims to solve these issues using a novel method of fabrication of fibers featuring confinement of drugs within a biodegradable core-shell structure, thereby permitting sustained release of drugs to specific sites of treatment, such as tissues affected with tumor cells. The coaxial electrospinning was performed using a sheath polymer solution consisting of a 14 wt% PCL solution and a 5 wt% solution of 5-FU as the core solution. Dimethylformamide (DMF) was used as the solvent ...


Multivariate Analysis Of Mr Images In Temporal Lobe Epilepsy, Diego H. Cantor-Rivera 2015 The University of Western Ontario

Multivariate Analysis Of Mr Images In Temporal Lobe Epilepsy, Diego H. Cantor-Rivera

University of Western Ontario - Electronic Thesis and Dissertation Repository

Epilepsy stands aside from other neurological diseases because clinical patterns of progression are unknown: The etiology of each epilepsy case is unique and so it is the individual prognosis. Temporal lobe epilepsy (TLE) is the most frequent type of focal epilepsy and the surgical excision of the hippocampus and the surrounding tissue is an accepted treatment in refractory cases, specially when seizures become frequent increasingly affecting the performance of daily tasks and significantly decreasing the quality of life of the patient. The sensitivity of clinical imaging is poor for patients with no hippocampal involvement and invasive procedures such as the ...


In-Vivo Corrosion And Fretting Of Modular Ti-6al-4v/Co-Cr-Mo Hip Prostheses: The Influence Of Microstructure And Design Parameters, Jose Luis Gonzalez Jr 2015 Florida International University

In-Vivo Corrosion And Fretting Of Modular Ti-6al-4v/Co-Cr-Mo Hip Prostheses: The Influence Of Microstructure And Design Parameters, Jose Luis Gonzalez Jr

FIU Electronic Theses and Dissertations

The purpose of this study was to evaluate the incidence of corrosion and fretting in 48 retrieved titanium-6aluminum-4vanadium and/or cobalt-chromium-molybdenum modular total hip prosthesis with respect to alloy material microstructure and design parameters. The results revealed vastly different performance results for the wide array of microstructures examined. Severe corrosion/fretting was seen in 100% of as-cast, 24% of low carbon wrought, 9% of high carbon wrought and 5% of solution heat treated cobalt-chrome. Severe corrosion/fretting was observed in 60% of Ti-6Al-4V components. Design features which allow for fluid entry and stagnation, amplification of contact pressure and/or increased ...


Osteoarthritis Induced Glenoid Morphology And Bone Quality: An Evaluation Of Augmented Glenoid Components, Nikolas K. Knowles 2015 The University of Western Ontario

Osteoarthritis Induced Glenoid Morphology And Bone Quality: An Evaluation Of Augmented Glenoid Components, Nikolas K. Knowles

University of Western Ontario - Electronic Thesis and Dissertation Repository

Osteoarthritis of the glenoid results in regional bone density variations and bone loss that may compromise early component fixation and support. The two common morphologies, symmetric and asymmetric erosion, were characterized by bone density and morphology, and assessed on the basis of bone removal and bone quality in the context of augmented glenoid components. The bone strain field was also compared when different augmented glenoid components underwent simulated joint loading using finite element analysis.

Asymmetrically eroded glenoids were found to have denser bone (p<0.001) and fewer voids (p<0.05) in the posteroinferior quadrant, while symmetrically eroded glenoids were found to have a uniform density distribution. Asymmetric glenoid erosion was found to be oriented 28 ± 11° from the superoinferior axis toward the posterior region, which resulted in increased bone removal when placing various augmented glenoid component designs. No correlation was found between the bone strain field and bone density under joint loading of augmented glenoid components using finite element analysis.


Finite Element Analysis (Fea) Of The Taper-Trunnion Interface In A Metal On Metal Hip Implant, Kyle M. Bradley, Timothy L. Norman, Thomas K. Fehring 2015 Cedarville University

Finite Element Analysis (Fea) Of The Taper-Trunnion Interface In A Metal On Metal Hip Implant, Kyle M. Bradley, Timothy L. Norman, Thomas K. Fehring

The Research and Scholarship Symposium

Metal on metal total hip replacements are a common procedure in which the hip joint is replaced with a metal stem, a metal femoral head and a metal socket, usually made of titanium or cobalt chromium. The stem has a tapered region (trunnion) where the femoral head is impacted onto. This creates what is known as the taper-trunnion interface within a hip implant. However, these hip implants seem to be very susceptible to fretting corrosion, where the corrosive fluid environment of the body accelerates the process of wear between two contact surfaces. Previous research has suggested that the design parameters ...


Cilia Have A Significant Role In Regulating Cell Size In Response To Fluid Flow Induced Shear Stress In A Flow Chamber, Ryan M. Hecklinger, Schuyler E. Price, Matthew B. Welkie Jr., Timothy L. Norman, Elisha R. Injeti 2015 Cedarville University

Cilia Have A Significant Role In Regulating Cell Size In Response To Fluid Flow Induced Shear Stress In A Flow Chamber, Ryan M. Hecklinger, Schuyler E. Price, Matthew B. Welkie Jr., Timothy L. Norman, Elisha R. Injeti

The Research and Scholarship Symposium

Cilia are hair-like protrusions on the apical surface of cells. Their function is to relay mechanical signals like shear stress from extracellular into intracellular environment and thereby maintain cellular homeostasis. Ciliary dysfunctions include polycystic kidney disease and new therapeutic interventions based on ciliary function are under investigation. The current study evaluates the use of a custom designed fluid flow chamber’s ability to study the role of cilia in regulating cell size in response to shear stress.

A fluid flow chamber that continually maintains laminar flow at different flow rates and temperature was designed. Endothelial wild type cells (ETWT) that ...


Design Of Tkr Tibial Insert For Bowlegged Gait, Michael R. Gardner, Nathan A. Hanbury, Joel D. Hutchison, Dana C. Madsen, Joel D. Slabach, Kyle M. Bradley, Timothy L. Norman, J. D. Blaha 2015 Cedarville University

Design Of Tkr Tibial Insert For Bowlegged Gait, Michael R. Gardner, Nathan A. Hanbury, Joel D. Hutchison, Dana C. Madsen, Joel D. Slabach, Kyle M. Bradley, Timothy L. Norman, J. D. Blaha

The Research and Scholarship Symposium

One of the causes associated with total knee replacement (TKR) surgery is abnormal gait. In these gait cases, however, the TKR does not solve the ultimate issue because abnormal gait still occurs, and similar excessive forces still occur on the knee. It is likely that the TKR will experience accelerated wear, and the individual may have to undergo a second TKR sometime in the future. For our purposes, bowleggedness is either the external rotation of the hip or excessive varus of the knee. It was hypothesized that the inability to internally rotate the hip increases adduction moment and medial compartment ...


Developments In Opto-Electronic Holography (Oeh) For Measurement Of Sound-Induced Eardrum Motion, Ivo Dobrev, Jeffrey Tao Cheng, Morteza Khaleghi, Jérémie Guignard, Michael E. Ravicz, John J. Rosowski, Cosme Furlong 2015 Worcester Polytechnic Institute

Developments In Opto-Electronic Holography (Oeh) For Measurement Of Sound-Induced Eardrum Motion, Ivo Dobrev, Jeffrey Tao Cheng, Morteza Khaleghi, Jérémie Guignard, Michael E. Ravicz, John J. Rosowski, Cosme Furlong

Ivo Dobrev

Prior to 2009 the data available to characterize the function of the mammalian eardrum was rather limited and consisted of time-averaged holograms gathered 30 to 40 years previously or laser-vibrometer measurements usually made with low spatial density or over small regions of the eardrum. These few measurements could be compared to the plethora of Finite-Element models of eardrum and middle ear function. More recently, a collaboration between an optics group at the Center for Holographic Studies and Laser micro-mechaTronics at the Worcester Polytechnic Institute in Worcester MA and physiologists and acousticians at the Eaton-Peabody Laboratory at the Massachusetts Eye and ...


Sound-Induced In-Plane And Out-Of-Plane Motion Of Human Tympanic Membranes, Morteza Khaleghi, Jeffrey T. Cheng, Cosme Furlong, John J. Rosowski 2015 Worcester Polytechnic Institute

Sound-Induced In-Plane And Out-Of-Plane Motion Of Human Tympanic Membranes, Morteza Khaleghi, Jeffrey T. Cheng, Cosme Furlong, John J. Rosowski

Morteza Khaleghi

The acousto-mechanical-transformer behavior of the Tympanic Membrane (TM) is determined by its geometry (shape and thickness) and mechanical properties. The questions of “How the TM couples acoustic energy to the ossicles?” and “How TM shape and vibration affect this series of events?” have yet to be fully answered. Holographic studies of 1D vibrations of the TM have been reported by several groups; however, 3D measurements of TM motions are few. In this study, we use full-field-of-view holographic techniques to measure near simultaneously the shape and 3D sound-induced displacement of cadaveric human TMs. Combinations of shape and 3D displacement measurements are ...


Altered Cd161bright Cd8+ Mucosal Associated Invariant T (Mait)-Like Cell Dynamics And Increased Differentiation States Among Juvenile Type 1 Diabetics., Robert Z. Harms, Kristina M. Lorenzo, Kevin P. Corley, Monina S. Cabrera, Nora Sarvetnick 2015 University of Nebraska Medical Center

Altered Cd161bright Cd8+ Mucosal Associated Invariant T (Mait)-Like Cell Dynamics And Increased Differentiation States Among Juvenile Type 1 Diabetics., Robert Z. Harms, Kristina M. Lorenzo, Kevin P. Corley, Monina S. Cabrera, Nora Sarvetnick

Journal Articles: Regenerative Medicine

Type 1A diabetes (T1D) is believed to be caused by immune-mediated destruction of β-cells, but the immunological basis for T1D remains controversial. Microbial diversity promotes the maturation and activation of certain immune subsets, including CD161bright CD8+ mucosal associated invariant T (MAIT) cells, and alterations in gut mucosal responses have been reported in type 1 diabetics (T1Ds). We analyzed T cell populations in peripheral blood leukocytes from juvenile T1Ds and healthy controls. We found that proportion and absolute number of MAIT cells were similar between T1Ds and controls. Furthermore, while MAIT cell proportions increased with age among healthy controls, this trend ...


Transitioning The Benefits Of Algal Growth To The Byproducts Of Oil And Natural Gas Production, Alan Hodges, Tyler Gladwin, Cody Maxfield, Jonathan Wood 2015 Utah State University

Transitioning The Benefits Of Algal Growth To The Byproducts Of Oil And Natural Gas Production, Alan Hodges, Tyler Gladwin, Cody Maxfield, Jonathan Wood

Research on Capitol Hill

No abstract provided.


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