Novel Platform Development Using An Assembly Of Carbon Nanotube, Nanogold And Immobilized Rna Capture Element Towards Rapid, Selective Sensing Of Bacteria, 2016 Wright State University - Main Campus
Novel Platform Development Using An Assembly Of Carbon Nanotube, Nanogold And Immobilized Rna Capture Element Towards Rapid, Selective Sensing Of Bacteria, Elizabeth I. Maurer, Kristen K. Comfort, Saber M. Hussain, John J. Schlager, Sharmila M. Mukhopadhyay
Sharmila M. Mukhopadhyay
This study examines the creation of a nano-featured biosensor platform designed for the rapid and selective detection of the bacterium Escherichia coli. The foundation of this sensor is carbon nanotubes decorated with gold nanoparticles that are modified with a specific, surface adherent ribonucleic acid (RNA) sequence element. The multi-step sensor assembly was accomplished by growing carbon nanotubes on a graphite substrate, the direct synthesis of gold nanoparticles on the nanotube surface, and the attachment of thiolated RNA to the bound nanoparticles.
The application of the compounded nanomaterials for sensor development has the distinct advantage of retaining the electrical behavior property ...
Somatic Stimulation Causes Frontoparietal Cortical Changes In Neonates: A Functional Near-Infrared Spectroscopy Study, 2016 Wright State University - Main Campus
Somatic Stimulation Causes Frontoparietal Cortical Changes In Neonates: A Functional Near-Infrared Spectroscopy Study, Nasser H. Kashou, Irfaan Akram Dar, Kathryn Hasenstab, Ramzi W. Nahhas, Sudarshan R. Jadcherla
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Palmar and plantar grasp are the foremost primitive neonatal reflexes and functions. Persistence of these reflexes in infancy is a sign of evolving cerebral palsy. Our aims were to establish measurement feasibility in a clinical setting and to characterize changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbD) concentration in the bilateral frontoparietal cortex in unsedated neonates at the crib-side using functional near-infrared spectroscopy (fNIRS). We hypothesized that bilateral concentration changes will occur upon somatic central and peripheral somatic stimulation. Thirteen preterm neonates (five males) underwent time 1, and six (two males) returned for time 2 (mean PMA ¼ 41.6 and ...
Modeling Effective Connectivity In High-Dimensional Cortical Source Signals, 2016 University of California, Irvine
Modeling Effective Connectivity In High-Dimensional Cortical Source Signals, Yuxiao Wang, Chee-Ming Ting Phd, Hernando Ombao
Chee-Ming Ting PhD
A Study On Biocompatibility Of Carbon Nanoparticles In Hela Cells Dictated By Synthesis And Sterilization, 2016 University of Salento
A Study On Biocompatibility Of Carbon Nanoparticles In Hela Cells Dictated By Synthesis And Sterilization, Elisa Panzarini, Cristian Vergallo, Stefania Mariano
Optimization Of The Design Of An Amphiphilic Biodegradable Polymer For Tissue-Engineering Application, 2016 University of Massachusetts Medical School
Optimization Of The Design Of An Amphiphilic Biodegradable Polymer For Tissue-Engineering Application, Ben Zhang, Tera M. Filion, Jie Song
Biodegradable polymers have been widely utilized as drug delivery vehicles and tissue engineering scaffolds. We previously designed amphiphilic triblock copolymer poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) (PELA) and its hydroxyapatite (HA) composites for bone tissue engineering applications. The hydrophilic electrospun PELA-HA composite exhibited aqueous stability and elastic handling characteristics, and was able to template the proliferation and osteogenesis of bone marrow stromal cells (BMSCs) in vitro and in vivo when spiral-wrapped into cylinders and press-fit into critical size femoral segmental defects in rats. However, the slow degradation of PELA has prevented timely disappearance of the scaffold and ...
Microscale Investigation Of Thermo-Fluid Transport In The Transition Fil, Region Of An Evaporating Capillary Meniscus Using A Microgravity Environment, 2016 University of Tennessee, Knoxville
Microscale Investigation Of Thermo-Fluid Transport In The Transition Fil, Region Of An Evaporating Capillary Meniscus Using A Microgravity Environment, Kenneth D. Kihm, Jeffrey S. Allen, Kevin P. Hallinan, David M. Pratt
In order to enhance the fundamental understanding of thin film evaporation and thereby improve the critical design concept for two-phase heat transfer devices, microscale heat and mass transport is to be investigated for the transition film region using state-of-the-art optical diagnostic techniques. By utilizing a microgravity environment, the length scales of the transition film region can be extended sufficiently, from submicron to micron, to probe and measure the microscale transport fields which are affected by intermolecular forces. Extension of the thin film dimensions under microgravity will be achieved by using a conical evaporator made of a thin silicon substrate under ...
Nanocharacterization Of Bio-Silica Using Atomic Force And Ultrasonic Force Microscopy, 2016 Brown University
Nanocharacterization Of Bio-Silica Using Atomic Force And Ultrasonic Force Microscopy, Vinaypreet S. Gill, Kevin P. Hallinan, N. S. Brar
Nanotechnology has become central to our research efforts to fabricate relatively smaller size devices, which are more versatile than their older and larger predecessors. Silica is a very important material in this regard. Recently, a new biomimetically inspired path to silica production has been demonstrated. This processing technique was inspired from biological organisms, such as marine diatoms, which produce silica at ambient conditions and almost neutral ph with beautiful control over location and structure. Recently, several researchers have demonstrated that positional control of silica formed could be achieved by application of an electric field to locate charged enzymes responsible for ...
Leveraging Students’ Passion And Creativity: Ethos At The University Of Dayton, 2016 University of Dayton
Leveraging Students’ Passion And Creativity: Ethos At The University Of Dayton, Margaret Pinnell, Malcolm Daniels, Kevin P. Hallinan, Gretchen Berkemeier
The Engineers in Technical Humanitarian Opportunities of Service-learning (ETHOS) program was developed in the spring of 2001 by an interdisciplinary group (electrical, chemical, civil and mechanical) of undergraduate engineering students at the University of Dayton (UD). ETHOS was founded on the belief that engineers are more apt and capable to appropriately serve our world if they have an understanding of technology’s global linkage with values, culture, society, politics, and the economy. Since 2001, the ETHOS program at UD has grown and changed.
From conceptualization, to implementation, to maturation and national recognition, the program has addressed challenges of academic acceptance ...
Industrial Solid-State Energy Harvesting: Mechanisms And Examples, 2016 Carnegie Mellon University
Industrial Solid-State Energy Harvesting: Mechanisms And Examples, Matthew Kocoloski, Carl Eger, Robin Mccarty, Kevin P. Hallinan, J. Kelly Kissock
This paper explores the potential for solid-state energy harvesting in industrial applications. In contrast to traditional heat recovery, the output of solid-state devices is electricity, which can be readily used in virtually any plant. The progress in harvesting waste heat via thermoelectric and thermionic generators is described. With second law efficiencies now approaching 50% and 80% respectively, we show that these technologies are on the cusp of practical use. Finally, we present an example of energy harvesting using thermionic devices in an industrial application. The example considers energy harvesting from a furnace at a glass manufacturing facility where exhaust gases ...
Energy Information Augmented Community-Based Energy Reduction, 2016 University of Dayton
Energy Information Augmented Community-Based Energy Reduction, Kevin P. Hallinan, Harvey Enns, Stephenie Ritchey, Phil Brodrick, Nathan Lammers, Nichole Hanus, Mark Rembert, Tony Rainsberger
More than one-half of all U.S. states have instituted energy efficiency mandates requiring utilities to reduce energy use. To achieve these goals, utilities have been permitted rate structures to help them incentivize energy reduction projects. This strategy is proving to be only modestly successful in stemming energy consumption growth. By the same token, community energy reduction programs have achieved moderate to very significant energy reduction. The research described here offers an important tool to strengthen the community energy reduction efforts—by providing such efforts energy information tailored to the energy use patterns of each building occupant. The information provided ...
Clean Energy Infrastructure Educational Initiative, 2016 University of Dayton
Clean Energy Infrastructure Educational Initiative, Kevin P. Hallinan, James A. Menart, Robert Gilbert
The Clean Energy Infrastructure Educational Initiative represents a collaborative effort by the University of Dayton, Wright State University and Sinclair Community College. This effort above all aimed to establish energy related programs at each of the universities while also providing outreach to the local, state-wide, and national communities. At the University of Dayton, the grant has aimed at: solidfying a newly created Master's program in Renewable and Clean Energy; helping to establish and staff a regional sustainability organization for SW Ohio. As well, as the prime grantee, the University of Dayton was responsible for ensuring curricular sharing between WSU ...
A Study Of The Fundamental Operations Of A Capillary Driven Heat Transfer Device In Both Normal And Low Gravity Part 1-Liquid Slug Formation In Low Gravity, Jeffrey S. Allen, Kevin P. Hallinan, Jack Lekan
Research has been conducted to observe the operation of a capillary pumped loop (CPL) in both normal and low gravity environments in order to ascertain the causes of device failure. The failures of capillary pumped heat transport devices in low gravity; specifically; evaporator dryout, are not understood and the available data for analyzing the failures is incomplete.
To observe failure in these devices an idealized experimental CPL was configured for testing in both a normal-gravity and a low-gravity environment. The experimental test loop was constructed completely of Pyrex tubing to allow for visualization of system operations. Heat was added to ...
Differential Association Of Vitronectin And Fibronectin With Glass And Electrospun Fibers Of A Poly (D-Lysine) /Poly (Acrylic Acid), 2016 University of South Florida
Differential Association Of Vitronectin And Fibronectin With Glass And Electrospun Fibers Of A Poly (D-Lysine) /Poly (Acrylic Acid), Syed Muhammad Sohaib Zafar Zafar
Graduate Theses and Dissertations
Proteins represent major constituent of the extracellular matrix which plays an important role in the formation, maintenance and remodeling of tissues, this project focuses on adsorption of two specific serum proteins fibronectin (FN) and vitronectin (VTN) responsible for mediating cell matrix interaction through integrin binding, tripeptide Arg-Gly-Asp (RGD) sequence found in these protein features are recognized by αβV3 integrin which ultimately helps in clot formation.
Phylogenetic And Experimental Characterization Of An Acyl-Acp Thioesterase Family Reveals Significant Diversity In Enzymatic Specificity And Activity, Fuyuan Jing, David C. Cantu, Jarmila Tvaruzkova, Jay P. Chipman, Basil J. Nikolau, Marna D. Yandeau-Nelson, Peter J. Reilly
Background: Acyl-acyl carrier protein thioesterases (acyl-ACP TEs) catalyze the hydrolysis of the thioester bond that links the acyl chain to the sulfhydryl group of the phosphopantetheine prosthetic group of ACP. This reaction terminates acyl chain elongation of fatty acid biosynthesis, and in plant seeds it is the biochemical determinant of the fatty acid compositions of storage lipids.
Results: To explore acyl-ACP TE diversity and to identify novel acyl ACP-TEs, 31 acyl-ACP TEs from wide-ranging phylogenetic sources were characterized to ascertain their in vivo activities and substrate specificities. These acylACP TEs were chosen by two different approaches: 1) 24 TEs were ...
Combining Real-Time Fmri Neurofeedback Training Of The Dlpfc With N-Back Practice Results In Neuroplastic Effects Confined To The Neurofeedback Target Region, 2016 Wright State University - Main Campus
Combining Real-Time Fmri Neurofeedback Training Of The Dlpfc With N-Back Practice Results In Neuroplastic Effects Confined To The Neurofeedback Target Region, Matthew Sherwood, Michael Patrick Weisend Ph.D., Jessica Kane, Jason G. Parker
The Development Of A Prosthetic Training Software For Upper Limb Amputees, 2016 University of South Florida
The Development Of A Prosthetic Training Software For Upper Limb Amputees, Tyler Kayne Sullins
Graduate Theses and Dissertations
The purpose of this study was to develop an intuitive software that aids in the field of prosthetic training and rehabilitation by creating an individualized visualization of joint angles. This software is titled “the prosthetic training software (PTS) for individualized joint angle representation”, and it enables the individualized portrayal of predicted or pre-recorded joint angles. The PTS is an intuitive program for clinicians and prosthesis users that produces an animation of a virtual avatar reflecting the user’s segment lengths and amputation for rehabilitation and training purposes.
The PTS consists of a graphical user interface (GUI) and a 3D visualization ...
Intracranial Pressure Sensor, 2016 Santa Clara University
Intracranial Pressure Sensor, Matthew Murray, Jared Shimada
Bioengineering Senior Theses
Idiopathic Intracranial Hypertension (IIH) also known as Pseudotumor Cerebri is a condition resulting from an increase of Cerebrospinal Fluid (CSF), a fluid that helps to protect the brain and spinal cord, in the cranial cavity. Currently the only treatment method for this health condition is the draining of the fluid via implanted intracranial shunts that get clogged in approximately 50% of patients. Clogged shunts can only be detected when IIH symptoms begin to reappear. We propose to create an ultrasound-read intracranial pressure sensor used to supplement shunts implanted in patients who suffer from Idiopathic Intracranial Hypertension. This will provide immediate ...
Preclinical Study For Targeted Breast Cancer Therapy, 2016 Santa Clara University
Preclinical Study For Targeted Breast Cancer Therapy, Katie Bond, Lauren Mccormick, Jordan Karroll
Bioengineering Senior Theses
Cancer is a devastating disease which affects millions. For this reason, many scientists are working to develop drugs that can specifically target cancer cells within the body. Preclinical trials are an important phase in the drug development process, as they allow scientists to determine whether or not a drug candidate may be viable for human use. Targeted therapies can be achieved by using monoclonal antibodies as well as small molecule drugs. In this study we compared the effects of two control monoclonal antibody drugs, “mAb1” and “mAb2,” with one small molecule drug, “Drug S,” on the MDAMB231 human breast cancer ...
Suture Passing Device For Hyoid Susupension In Sleep Apnea Surgery, 2016 Santa Clara University
Suture Passing Device For Hyoid Susupension In Sleep Apnea Surgery, Corbin Craven, Nicholas Leavengood, Solomon Mulugeta
Bioengineering Senior Theses
Obstructive Sleep Apnea (OSA) is a condition which is characterized by momentary pauses in a person’s breathing while they are sleeping. Current treatment options for sleep apnea include CPAP, oral appliances, and surgery. Of these options, hyoid suspension surgery is one of the most effective, but is significantly underutilized. This is due to the fact that performing hyoid suspension surgery by current methods is complicated and can be painful for the patient. As our senior design project, we designed and prototyped a novel medical device that facilitates fast, easy, and consistent hyoid suspension surgery. Through functional testing of our ...
Bolstering The Cell Membrane Of S. Cerevisiae For Efficient Bioethanol Production From Lignocellulosic Biomass, 2016 Santa Clara University
Bolstering The Cell Membrane Of S. Cerevisiae For Efficient Bioethanol Production From Lignocellulosic Biomass, Conary Meyer, Matt Kubit
Bioengineering Senior Theses
With the need for alternatives to fossil fuels becoming more prevalent, biofuels has become an increasingly attractive alternative. Traditional biofuel production was quickly halted as a result of its ethical complications, leading to the development of secondgeneration biofuels. This system utilizes plant waste instead of food as its starting material, allowing for rapid recycling of this widely available and cheap carbon source. This switch was, however, coupled with complications. Of those, the most prominent is the inevitable release of acetic acid resulting from the breakdown of the lignocellulosic waste. This acetic acid is challenging to neutralize or extract in a ...