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Spontaneous Firing Of Sensory Neurons Modulates The Gain In The Downstream Circuit Of A Simple Olfactory System, Matthew O'Neill 2015 Washington University in St Louis

Spontaneous Firing Of Sensory Neurons Modulates The Gain In The Downstream Circuit Of A Simple Olfactory System, Matthew O'Neill

Engineering and Applied Science Theses & Dissertations

In locusts and other insects, odorants are transduced into electrical signal by the olfactory receptor neurons and transmitted to central circuits for further processing. Previous studies have shown that exogenous variables (e.g., flow rates, humidity, temperature, odor mixtures, etc.) can influence the responses of the sensory neurons and therefore modulate the central circuits. However, how the sensory neuron activity is manipulated to achieve adaptive gain control in the following circuit is yet to be understood. It is possible that the magnitude of the stimulus-evoked response in the receptor neurons, their spontaneous activity, or both of these factors can change ...


A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device, Taylor Davis 2015 California Polytechnic State University - San Luis Obispo

A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device, Taylor Davis

Biomedical Eng/General Eng.

The company G-Force CRC LLC is currently experiencing the dichotomy of the FDA's conflicting role right now as they begin to approach FDA approval. G-Force CRC LLC is a small medical device company headquartered in San Diego, CA. The owner of the company, Dr. Ian Purcell, is an Otoneurologist apart of Alvarado Hospital. His medical practice mainly deals with patients who have balance disorders and therefore the devices that he has developed over the last 6+ years are primarily used to assist in the diagnosis of those balance disorders. G-Force CRC LLC was officially created in the summer of ...


Sapien3 Comb Stitch Improvement For Edwards Lifesciences, William Harley, Thomas Pluschkell, John McTigue, Garrett Reed 2015 California Polytechnic State University - San Luis Obispo

Sapien3 Comb Stitch Improvement For Edwards Lifesciences, William Harley, Thomas Pluschkell, John Mctigue, Garrett Reed

Mechanical Engineering

The complete senior project report was submitted to the project advisor and sponsor. The results of this project are of a confidential nature and will not be published at this time.


Transcatheter Heart Valve Subassembly Device, Adam Aslam, Matthew Bezkrovny, Daniel DeGree 2015 California Polytechnic State University - San Luis Obispo

Transcatheter Heart Valve Subassembly Device, Adam Aslam, Matthew Bezkrovny, Daniel Degree

Mechanical Engineering

No abstract provided.


Renal Artery Stent Fatigue Test, Braden Cooper, Munir Eltal, Jennifer Hawthorne, Ashley Schaefer 2015 California Polytechnic State University - San Luis Obispo

Renal Artery Stent Fatigue Test, Braden Cooper, Munir Eltal, Jennifer Hawthorne, Ashley Schaefer

Mechanical Engineering

In today’s world of medical innovation, regulations and requirements set by organizations such as the Food and Drug Administration (FDA), the International Organization for Standardization (ISO), and ASTM International (American Society for Testing and Materials) can inhibit rapid innovation by demanding rigorous testing of new designs. For arterial stents, the standard is that each design must be tested to simulate 10 years of life in an environment congruent to an in vivo environment. Endologix in Irvine, California develops and manufactures minimally invasive treatments for aortic diseases, with a focus on stent grafts for the treatment of abdominal aortic aneurysms ...


Multiphysics Modeling To Enhance Understanding Of Microwave Heating Of Food In Domestic Ovens, Jiajia Chen 2015 University of Nebraska-Lincoln

Multiphysics Modeling To Enhance Understanding Of Microwave Heating Of Food In Domestic Ovens, Jiajia Chen

Biological Systems Engineering--Dissertations, Theses, and Student Research

Nonuniform heating is the biggest issue in the microwave heating of prepared meals. Multiphysics based models are promising tools to improve microwave heating uniformity by properly designing the food product. However, limited availability of accurate temperature-dependent material properties, inadequate model prediction accuracy, and high computational power and complexity in model development are three gaps that greatly limited the application of these models in the food industry.

To fill in the gaps, firstly, we developed a multitemperature calibration protocol to measure temperature-dependent dielectric properties (dielectric constant and loss factor). The temperature-dependent dielectric and thermal (thermal conductivity and specific heat capacity) properties ...


Computational Fluid Dynamics Applied To The Analysis Of Blood Flow Through Central Aortic To Pulmonary Artery Shunts, Carey Celestin Jr 2015 University of New Orleans

Computational Fluid Dynamics Applied To The Analysis Of Blood Flow Through Central Aortic To Pulmonary Artery Shunts, Carey Celestin Jr

University of New Orleans Theses and Dissertations

This research utilizes CFD to analyze blood flow through pathways representative of central shunts, commonly used as part of the Fontan procedure to treat cyanotic heart disease. In the first part of this research, a parametric study of steady, Newtonian blood flow through parabolic pathways was performed to demonstrate the effect that flow pathway curvature has on wall shear stress distribution and flow energy losses. In the second part, blood flow through two shunts obtained via biplane angiograms is simulated. Pressure boundary conditions were obtained via catheterization. Results showed that wall shear stresses were of sufficient magnitude to initiate platelet ...


Gold Nanostructures For Sensing And Functional Bioimaging, Maximilian Y. Fei 2015 Washington University in St Louis

Gold Nanostructures For Sensing And Functional Bioimaging, Maximilian Y. Fei

Engineering and Applied Science Theses & Dissertations

Gold nanostructures offer an extremely promising path forward in the fields of imaging and sensing because of their unique optical and chemical properties. Here, we demonstrate that plasmonic nanostructures can be employed as nanoscale transducers to monitor the growth and phase transitions in ultrathin polymer films. In particular, gold nanorods with high refractive index sensitivity (~150 nm / refractive index unit (RIU)) were employed to probe the growth and swelling of polyelectrolyte multilayers (PEM). By comparing the wavelength shift and extinction intensity of the localized surface plasmon resonance (LSPR) of the gold nanorods coated with PEM in air and water, the ...


Regional Anesthesiology Ultrasound-Guided Nerve Block Simulator, Avik Purkayastha, David Call, Mehdi Zare, Michael Fister 2015 University of Tennessee, Knoxville

Regional Anesthesiology Ultrasound-Guided Nerve Block Simulator, Avik Purkayastha, David Call, Mehdi Zare, Michael Fister

Biomedical and Diagnostic Sciences Publications and Other Works

The purpose of the model is to allow residents in anesthesiology to practice the ultrasound guided supraclavicular nerve block procedure without having to practice on an actual patient so that they can hone their skills before performing the actual procedure. Our goals when creating the device were having a life-like feel, having the model be anatomically correct, and having the model provide an accurate ultrasound. After 3 iterations we were able to satisfy all 3 requirements but the most accurate ultrasound was provided by the second model, which did we believed did not satisfy the other requirements well enough. For ...


A Space-Variant Model For Motion Interpretation Across The Visual Field, Guido Maiello, Manuela Chessa, Peter J. Bex, Fabio Solari 2015 University College London

A Space-Variant Model For Motion Interpretation Across The Visual Field, Guido Maiello, Manuela Chessa, Peter J. Bex, Fabio Solari

MODVIS Workshop

We implement a neural model for the estimation of the focus of radial motion (FRM) at different retinal locations and we assess the model by comparing its results with respect to the precision with which human observers can estimate the FRM in naturalistic, moving dead leaves stimuli. The proposed neural model describes the deep hierarchy of the first stages of the dorsal visual pathway [Solari et al., 2014]. Such a model is space-variant, since it takes into account the retino-cortical transformation of the primate visual system through log-polar mapping that produces a cortical representation of the visual signal to the ...


Fiber Optic Bandage, Logan McNeil, Cameron Pilkey, Brittani Erwin, Adam Wojnar 2015 University of Tennessee - Knoxville

Fiber Optic Bandage, Logan Mcneil, Cameron Pilkey, Brittani Erwin, Adam Wojnar

Biomedical and Diagnostic Sciences Publications and Other Works

The purpose of this document is to show the report for the Fiber optic device formulated through the biomedical engineering department with a senior design group. A growing issue in medical technology is open wound care. Particularly prevalent in diabetics, open wound care is expensive and time consuming. Certain wavelengths of light have not only shown to have germicidal properties, but also allow cell growth and regeneration. The following design was founded around these ideas, and an initial design was developed. The design centered around using fiber optics as a means of replacing a wet bandage in a normal wound ...


3d Printing In Healthcare, Caleb Branch 2015 St. John Fisher College

3d Printing In Healthcare, Caleb Branch

Undergraduate Review: A Journal of Undergraduate Student Research

Technology is everywhere. Technology surrounds every aspect of 21st century life. It is in the cell phones we use, the cars we drive, and even the food we eat. A large portion of modern technology used is taken for granted and overlooked. Despite this, some technology fields continue to grow. Biomedical engineering, specifically 3D printing’s applications to healthcare, has been often overlooked until. Regardless of its status in the mainstream, 3D printing is prosperous in healthcare and its future looks bright. This piece analyzes 3D printing in healthcare. It hones in on the finer details of each specific ...


Fiber Optic Bandage, Logan McNeil 2015 University of Tennessee, Knoxville

Fiber Optic Bandage, Logan Mcneil

University of Tennessee Honors Thesis Projects

No abstract provided.


Ultrasound-Guided Regional Anesthesia Nerve Block Simulator, Avik Purkayastha, David Call, Alex Zare, Michael Fister 2015 University of Tennessee, Knoxville

Ultrasound-Guided Regional Anesthesia Nerve Block Simulator, Avik Purkayastha, David Call, Alex Zare, Michael Fister

University of Tennessee Honors Thesis Projects

No abstract provided.


Mitochondrial Dysfunction And Loss Of Glutamate Uptake In Primary Astrocytes Exposed To Titanium Dioxide Nanoparticles, Christina L. Wilson 2015 University of Nebraska-Lincoln

Mitochondrial Dysfunction And Loss Of Glutamate Uptake In Primary Astrocytes Exposed To Titanium Dioxide Nanoparticles, Christina L. Wilson

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

The proper function of astrocytes is critical for brain health as they are the most abundant cells in the brain which monitor ion homeostasis, recycle neurotransmitters and respond to tissue damage therefore disruption in astrocyte function can result in overall detrimental effects and has been linked with neurodegenerative diseases. Titanium Dioxide (TiO2) nanoparticles are currently the second most produced engineered nanomaterial in the world with vast usage in consumer products leading to recurrent human exposure. Animal studies indicate significant nanoparticle accumulation in the brain while cellular toxicity studies demonstrate negative effects on neuronal cell viability and function. However, the ...


Vcare: A Personal Emergency Response System To Promote Safe And Independent Living Among Elders Staying By Themselves In Community Or Residential Settings, Priyankar Bhattacharjee 2015 University of Nebraska-Lincoln

Vcare: A Personal Emergency Response System To Promote Safe And Independent Living Among Elders Staying By Themselves In Community Or Residential Settings, Priyankar Bhattacharjee

Dissertations & Student Research in Computer Electronics & Engineering

‘Population aging’ is a growing concern for most of us living in the twenty first century, primarily because many of us in the next few years will have a senior person to care for - spending money towards their healthcare expenditures AND/OR having to balance a full-time job with the responsibility of care-giving, travelling from another city to be with this elderly citizen who might be our parent, grand-parent or even community elders. As informal care-givers, if somehow we were able to monitor the day-to-day activities of our elderly dependents, and be alerted when wrong happens to them that would ...


Doping Of Fluorchlorozirconate And Borate-Silica Glass Ceramics For Medical Imaging And Fast Neutron Scintillation, Julie Elizabeth Swafford 2015 University of Tennessee - Knoxville

Doping Of Fluorchlorozirconate And Borate-Silica Glass Ceramics For Medical Imaging And Fast Neutron Scintillation, Julie Elizabeth Swafford

Masters Theses

Borate silica glass ceramics were produced for neutron scintillation. The Glass ceramics were doped with europium fluoride [EuF2] and cerium chloride [CeCl3]. Isotopic lithium fluoride [6LiF] and boron oxide [10B2O3] were used in most samples while non-isotopic lithium fluoride [LiF] and boron oxide [ B2O3] were used in the rest. When exposed to a neutron beam, samples doped with europium fluoride [EuF2] scintillated while samples doped with cerium chloride [CeCl3] did not. This contradicts current literature on fast scintillation. What is even more significant is that with europium fluoride ...


Assessment Of Bore-Cone Taper Junctions In Explanted Modular Total Hip Replacements, Christine Margaret Stamer 2015 Clemson University

Assessment Of Bore-Cone Taper Junctions In Explanted Modular Total Hip Replacements, Christine Margaret Stamer

All Theses

For people with chronic hip pain due to arthritis or other conditions, a total hip replacement (THR) is a common procedure used to eliminate the pain. Due to the natural variation in patient anatomy, THR prostheses are becoming increasingly more modular to allow for a more customized initial replacement and for an easier revision if needed in the future. Currently, THR prostheses routinely have modular femoral heads to provide surgeons with intraoperative flexibility. This modularity allows the surgeons to maintain the proper leg length and restore hip biomechanics for the patient and insert the components more easily and precisely. Modular ...


Effect Of Ion Concentration On Mechanosynthesis Of Carbonated Chlorapatite Nanopowders, 2015 SelectedWorks

Effect Of Ion Concentration On Mechanosynthesis Of Carbonated Chlorapatite Nanopowders

Faculty of Engineering University of Malaya

Carbonated chlorapatite nanopowders (n-CCAp) with different degrees of substitution were successfully synthesized by the one-step mechanochemical process. Results demonstrated that the formation of n-CCAp was influenced strongly by the carbonate content (x). From X-ray analysis, crystallite size, crystallinity degree, and unit cell volume of n-CCAp decreased significantly as carbonate content (x) increased from 0 to 2. Conversely, the lattice strain and the volume fraction of grain boundaries grew considerably. Microscopic analysis showed the average particle size of the synthesized powders was 15 +/- 10 nm. The influence of carbonate concentration on mechanosynthesis of pure n-CCAp utilizing a facile solid-state process has ...


Force Sensing In Arthroscopic Instruments Using Fiber Bragg Gratings, Daniel S. Yurkewich 2015 The University of Western Ontario

Force Sensing In Arthroscopic Instruments Using Fiber Bragg Gratings, Daniel S. Yurkewich

University of Western Ontario - Electronic Thesis and Dissertation Repository

Minimally-invasive surgery has revolutionized many medical procedures; however, it also impedes the ability to feel the interaction between the surgical tool and the anatomical part being operated on. In order to address this problem, it is necessary to obtain accurate measurements of the interaction forces exerted on the surgical tools during surgery. These forces can then be manifested to the surgeon via a haptic device or presented visually (visual-force feedback). This thesis describes the use of a fiber optic device to measure and display to the surgeon interaction forces acting on an arthroscopic tool. The sensorization of the tool involves ...


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