Biomedical Engineering and Bioengineering Commons^™

Experimental And Numerical Investigation Of The Mechanism Of Blast Wave Transmission Through A Surrogate Head, Yi Hua, Praveen Akula, Linxia Gu, Jeff Berg, Carl A. Nelson

Mechanical & Materials Engineering Faculty Publications

This work is to develop an experiment-validated numerical model to elucidate the wave transmission mechanisms through a surrogate head under blast loading. Repeated shock tube tests were conducted on a surrogate head, i.e., water-filled polycarbonate shell. Surface strain on the skull simulant and pressure inside the brain simulant were recorded at multiple locations. A numerical model was developed to capture the shock wave propagation within the shock tube and the fluid-structure interaction between the shock wave and the surrogate head. The obtained numerical results were compared with the experimental measurements. The experiment-validated numerical model was then used to further ...

Integration Of Time-Resolved Fluorescence And Diffuse Reflectance Spectroscopy For Intraoperative Detection Of Brain Tumour Margin, Zhaojun Nie

Open Access Dissertations and Theses

The annual incidence rate of tumours in the brain and central nervous system (CNS) was 19.89 per 100,000 persons between 2004 and 2008 in the United States. Surgery is a common treatment option for brain and CNS tumours. Typically, biopsy followed by histological analysis is used to confirm tumour types and margin during neurosurgery as an intraoperative diagnostic tool. However, this biopsy method is invasive, sampling number limited and not in real-time. To overcome these problems, many minimally invasive optical techniques, called optical biopsies, have been developed towards intraoperative diagnosis.

The research work carried out in this dissertation ...

Vicon Motion System, Arezoo Eshraghi

AREZOO ESHRAGHI

No abstract provided.

Characterizing Phantom Arteries With Multi-Channel Laser Ultrasonics And Photo-Acoustics, Jami L. Johnson, Kasper Van Wijk, Michelle Sabick

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Multi-channel photo-acoustic and laser ultrasonic waves are used to sense the characteristics of proxies for healthy and diseased vessels. The acquisition system is non-contacting and non-invasive with a pulsed laser source and a laser vibrometer detector. As the wave signatures of our targets are typically low in amplitude, we exploit multi-channel acquisition and processing techniques. These are commonly used in seismology to improve the signal-to-noise ratio of data. We identify vessel proxies with a diameter on the order of 1 mm, at a depth of 18 mm. Variations in scattered and photo-acoustic signatures are related to differences in vessel wall ...

Cv, Arezoo Eshraghi

AREZOO ESHRAGHI

No abstract provided.

Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen

University of Western Ontario - Electronic Thesis and Dissertation Repository

Colloidal inorganic nanoparticles (NPs) have been attracting considerable interest in biomedicine, from drug and gene delivery to imaging, sensing and diagnostics. It is essential to modify the surface of nanoparticles to have enhanced biocompatibility and functionality for the in vitro and in vivo applications, especially in delivering locally and recognizing biomolecules. Herein, the goal of this research work is to develop advanced NPs with well-tailored surface functionalities and/or bio-functionality for the applications in cell tracking and analytes detection.

In the first project, quantum dots incorporating with gelatin nanoparticles (QDs-GNPs) have been developed for bioimaging applications. Two different approaches have ...

Correlation Between Energy Distribution Profile And Lev El Of Consciousness, D. K. Chaturvedi Dr.

D. K. Chaturvedi Dr.

The purpose of this experimental study was to determine the energy levels corresponding to the different focal points (Chakras or centers) of the body, which is related with consciousness. In this experiment, the energy level is measured at four different centers, namely, the navel center, the heart center, the throat center and the eye center of the Human beings. The measurements have been taken using Energy Measurement System (EMS) developed at Department of Electrical Engineering, Dayalbagh Education Institute, Dayalbagh, Agra, India, which works on the principle of tissue resistance of body. The probe was placed at different centers and subsequent ...

Design And Control Of A 2 Degree Of Freedom Upper Limb Robotic Rehabilitation Device, Patrick Joseph Murphy

Mechanical Engineering Master's Theses

Robotic neurorehabilitation is a rapidly growing field in both research and industry. Robotics offer the ability to create less labor-intensive rehabilitation for therapists, while providing an interactive experience for patients. Robotic therapy also provides the advantage of object data collection for therapists to track patient progress; however, there is still both a clinical and market need for a low-cost, assistive hand rehabilitation system. Therefore, the comprehensive design, control, and initial testing of an actuated, assistive 2 degree of freedom hand rehabilitation system with a virtual environment is presented.

The 2 degree of freedom hand rehabilitation system, named the Navigator hand ...

Design, Prototyping And Bench Testing For Biomedical Devices, Yu Pu

Mechanical Engineering Master's Theses

Bench testing for different torque based devices have different specific requirements, such as load and position requirements. Also, bench testing is very important for torque based devices before they go to real application. Therefore, bench design for new torque sensing product devices is crucial.

Three projects are included in this thesis. The first is the design and bench test for Customized Sensors for Humans Using an Integrated Polymer (C-SHIP). The second is the design and bench test for Patient Customized Ankle Foot Orthotics using Rapid Prototyping. The last is design a testbed for Gear Bearing Drives (GBD).

First, the design ...

Rsvp Keyboard: An Eeg Based Bci Typing System With Context Information Fusion, Umut Orhan

Electrical Engineering Dissertations

Worldwide, there are millions of people with severe motor and speech impairment, which prohibits them from participating in daily functional activities such as personal care. While many individuals may understand language fully and retain cognitive skills, they have no way to produce speech. Communication with other people, especially with their family members and care providers, becomes a significant challenge. Brain computer interface (BCI) is a technology that uses neural signals as the physiological input for various assistive technology applications. In BCIs, electroencephalography (EEG) has drawn increasing attention of the researchers due to noninvasiveness, portability, feasibility, and a relatively low cost ...

Transtibial Prosthesis, Hossein Gholizadeh

Hossein Gholizadeh

No abstract provided.

My Cv (January 2014), Hossein Gholizadeh

Hossein Gholizadeh

No abstract provided.

P&O, Arezoo Eshraghi

AREZOO ESHRAGHI

No abstract provided.

کارگاه اصول نگارش مقالات علمی 1, Dr Alireza Zolfaghari

Dr Alireza Zolfaghari

No abstract provided.

Under-Sampled Reconstructiontechniques For Accelerated Magnetic Resonance Imaging, Mohammad H. Kayvanrad

University of Western Ontario - Electronic Thesis and Dissertation Repository

Due to physical and biological constraints and requirements on the minimum resolution and SNR, the acquisition time is relatively long in magnetic resonance imaging (MRI). Consequently, a limited number of pulse sequences can be run in a clinical MRI session because of constraints on the total acquisition time due to patient comfort and cost considerations. Therefore, it is strongly desired to reduce the acquisition time without compromising the reconstruction quality. This thesis concerns under-sampled reconstruction techniques for acceleration of MRI acquisitions, i.e., parallel imaging and compressed sensing.

While compressed sensing MRI reconstructions are commonly regularized by penalizing the decimated ...

Temperature-Dependent Dielectric And Thermal Properties Of Whey Protein Gel And Mashed Potato, Jiajia Chen, Krishnamoorthy Pitchai, Sohan Birla, Ricardo Gonzalez, David Jones, Jeyamkondan Subbiah

Biological Systems Engineering: Papers and Publications

Temperature-dependent dielectric properties (dielectric constant and dielectric loss factor) and thermal properties (thermal conductivity and specific heat capacity) of whey protein gel and mashed potato were measured from -20°C to 100°C. A dielectric properties measurement system and a multipoint temperature calibration protocol were developed. The system consists of an impedance analyzer, a high-temperature coaxial cable, a high-temperature coaxial probe, a micro-climatic chamber and a metal sample holder. Calibrations at two temperatures (25°C and 85°C) were sufficient to accurately measure the dielectric properties of foods from frozen to hot temperatures. Both dielectric constant and dielectric loss factor ...

Biomimetic Poly(Ester Amide) Biomaterials For Vascular Tissue Engineering, Darryl K. Knight

University of Western Ontario - Electronic Thesis and Dissertation Repository

The focus of this research was to develop a biomimetic, degradable vascular scaffold that could be considered as part of a tissue-engineered vascular graft strategy. A family of degradable poly(ester amide)s (PEAs) derived from naturally occurring α-amino acids, aliphatic diols and diacids were synthesized to yield PEAs with glass transition temperatures below physiologic temperature ensuring their pliability. Tri-functional amino acids l-lysine or l-aspartic acid were incorporated into the polymer backbone yielding complementary functional handles for subsequent conjugation of growth factors. Higher molecular weight PEAs were obtained using an interfacial polycondensation technique compared with a solution polymerization approach.

Human ...

Near-Infrared Surface-Enhanced Fluorescence Using Silver Nanoparticles In Solution, Michael D. Furtaw

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Fluorescence spectroscopy is a widely used detection technology in many research and clinical assays. Further improvement to assay sensitivity may enable earlier diagnosis of disease, novel biomarker discovery, and ultimately, improved outcomes of clinical care along with reduction in costs. Near-infrared, surface-enhanced fluorescence (NIR-SEF) is a promising approach to improve assay sensitivity via simultaneous increase in signal with a reduction in background. This dissertation describes research conducted with the overall goal to determine the extent to which fluorescence in solution may be enhanced by altering specific variables involved in the formation of plasmonactive nanostructures of dye-labeled protein and silver nanoparticles ...

Mechanical Properties Of Bone Due To Sost Expression: Nanoindentation Assessment Of Murine Femurs, Amir Rafie

Master's Theses and Project Reports

In the human genome, the SOST gene codes for a protein sclerostin. Sclerostin is an osteocyte-expressed negative regulator of bone formation. When the SOST gene is not coded, bone formation is reduced in individuals during skeletal maturation. This study utilizes nanoindentation methods to test for the mechanical properties of bones that both express and do not express the SOST gene. 100 transgenic murine femurs were obtained from Lawrence Livermore Labs in the form of 6 and 8 month SOST transgenic mice, 6 and 12 month SOST knockout mice, and wild type control littermates for each of the 4 age groups ...

Functional 3-D Cellulose & Nitrocellulose Paper-Based, Mulitplex Diagnostic Platforms Without Coupling Agents, Mackenzie Elizabeth Tageson

Master's Theses and Project Reports

The purpose of this thesis was to demonstrate device functionality of 3-D paper-based, multiplex platforms, µPADs, without the use of coupling agents between layers. Previously, these platforms were fabricated with double-sided tape and cellulose powder to try to augment proper fluid routing, but difficulties with this method occurred. An acrylic housing unit with strategically placed pressure tabs was designed to aid horizontal and vertical fluid routing through the platform, thus eliminating the inconsistencies associated with coupling agents. Channel characterization studies, a COMSOL^TM simulation, and development time studies were performed to aid device design and demonstrate device functionality.

The implementation ...