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Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson 2016 University of Tennessee - Knoxville

Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson

Michael Johnson

Osteoarthritis (OA) of the knee is one of the leading causes of chronic disability (along with the hip). Due to rising healthcare costs associated with OA, it is important to fully understand the disease and how it progresses in the knee. One symptom of knee OA is the degeneration of cartilage in the articulating knee. The cartilage pad plays a major role in painting the biomechanical picture of the knee. This work attempts to quantify the cartilage thickness of healthy male and female knees using statistical shape models (SSMs) for a deep knee bend activity. Additionally, novel cartilage segmentation from ...


Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson 2016 University of Tennessee - Knoxville

Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson

Michael Johnson

Osteoarthritis (OA) of the knee is one of the leading causes of chronic disability (along with the hip). Due to rising healthcare costs associated with OA, it is important to fully understand the disease and how it progresses in the knee. One symptom of knee OA is the degeneration of cartilage in the articulating knee. The cartilage pad plays a major role in painting the biomechanical picture of the knee. This work attempts to quantify the cartilage thickness of healthy male and female knees using statistical shape models (SSMs) for a deep knee bend activity. Additionally, novel cartilage segmentation from ...


Evaluation System For Craniosynostosis Surgeries With Computer Simulation And Statistical Modelling, Jing Jin 2016 The University of Western Ontario

Evaluation System For Craniosynostosis Surgeries With Computer Simulation And Statistical Modelling, Jing Jin

Electronic Thesis and Dissertation Repository

Craniosynostosis is a pathology in infants when one or more sutures prematurely closed, leading to abnormal skull shape. It has been classified according to the specific suture that has been closed, each of which has a typical skull shape. Surgery is the common treatment to correct the deformed skull shape and to reduce the excessive intracranial pressure. Since every case is unique, the cranial facial teams have difficulties to select an optimum solution for a specific patient from multiple options. In addition, there is not an appropriate quantified measurement existed currently to help cranial facial team to quantitatively evaluate their ...


Technology Transfer: A View From The Trenches, Harvey Drucker 2016 University of New Hampshire

Technology Transfer: A View From The Trenches, Harvey Drucker

RISK: Health, Safety & Environment

Dr. Drucker, who has lab-wide responsibility for technology transfer at Argonne National Laboratory, argues that transferring rights in discoveries made through tax supported research to private entities can contribute to public welfare in many ways.


Overview Of Federal Technology Transfer, Lawrence Rudolph 2016 University of New Hampshire

Overview Of Federal Technology Transfer, Lawrence Rudolph

RISK: Health, Safety & Environment

Mr. Rudolph reviews approximately thirteen years of legal and political developments that have contributed to laws governing the extent to which private firms may secure rights in technology at least partly developed with federal funds.


Lipid Coated Microbubbles And Low Intensity Pulsed Ultrasound Enhance Chondrogenesis Of Human Mesenchymal Stem Cells In 3d Printed Scaffolds, Mitra Aliabouzar, Lijie Grace Zhang, Kausik Sarkar 2016 George Washington University

Lipid Coated Microbubbles And Low Intensity Pulsed Ultrasound Enhance Chondrogenesis Of Human Mesenchymal Stem Cells In 3d Printed Scaffolds, Mitra Aliabouzar, Lijie Grace Zhang, Kausik Sarkar

Medicine Faculty Publications

Lipid-coated microbubbles are used to enhance ultrasound imaging and drug delivery. Here we apply these microbubbles along with low intensity pulsed ultrasound (LIPUS) for the first time to enhance proliferation and chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in a 3D printed poly-(ethylene glycol)-diacrylate (PEG-DA) hydrogel scaffold. The hMSC proliferation increased up to 40% after 5 days of culture in the presence of 0.5% (v/v) microbubbles and LIPUS in contrast to 18% with LIPUS alone. We systematically varied the acoustic excitation parameters—excitation intensity, frequency and duty cycle—to find 30 mW/cm2, 1.5 ...


Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont 2016 Selected Works

Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont

R. Dupont

No abstract provided.


Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont 2016 Utah State University

Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont

R. Dupont

No abstract provided.


Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont 2016 Utah State University

Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont

R. Dupont

No abstract provided.


Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont 2016 Utah State University

Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont

R. Dupont

No abstract provided.


Comparing The Tensile And Compressive Young’S Moduli Of Cortical Bone, Deshawn Hoskins, Meir Barak 2016 Clemson University

Comparing The Tensile And Compressive Young’S Moduli Of Cortical Bone, Deshawn Hoskins, Meir Barak

The Winthrop McNair Research Bulletin

Various methods have been used in the testing of the mechanical properties of cortical bone, specifically the young’s modulus. However, in the case of the material’s Young’s modulus in compression and tension, there is a significant disagreement among the published findings that may be a result of experimental artifacts. This study attempts to solve the scientific question of whether cortical bone is stiffer in compression or tension and if so to understand why that is. Using small samples taken from the distal portion of the neck of a femur belonging to a young white tailed deer, both ...


Electrospinning Of Poly (Ester Amide) Fibres For Mesenchymal Progenitor Cell Differentiation, Sarah Kiros 2016 The University of Western Ontario

Electrospinning Of Poly (Ester Amide) Fibres For Mesenchymal Progenitor Cell Differentiation, Sarah Kiros

Electronic Thesis and Dissertation Repository

The in vitro vascular tissue engineering paradigm seeks to produce biologically responsive vascular substitutes using cells, biodegradable scaffolds, and bioreactors to mature the tissue for the potential treatment of vascular occlusions and to create 3D tissue models for pre-clinical testing. In this work, a poly (ester amide) (PEA) derived from from L-phenylalanine, sebacoyl chloride and 1,4 butanediol was synthesized and electrospun to form both 3D fibrous mats and tubular constructs. Both the polymer solution concentration and mandrel rotation speed were optimized to fabricate bead-free fibres. Cytocompatibility and proliferation studies using mesenchymal progenitor 10T1/2 cells showed PEA fibres were ...


Price Controls Through The Back Door: The Parallel Importation Of Pharmaceuticals, A. Bryan Baer 2016 University of Georgia School of Law

Price Controls Through The Back Door: The Parallel Importation Of Pharmaceuticals, A. Bryan Baer

Journal of Intellectual Property Law

No abstract provided.


Neurosurgical Ultrasound Pose Estimation Using Image-Based Registration And Sensor Fusion - A Feasibility Study, Utsav Pardasani 2016 The University of Western Ontario

Neurosurgical Ultrasound Pose Estimation Using Image-Based Registration And Sensor Fusion - A Feasibility Study, Utsav Pardasani

Electronic Thesis and Dissertation Repository

Modern neurosurgical procedures often rely on computer-assisted real-time guidance using multiple medical imaging modalities. State-of-the-art commercial products enable the fusion of pre-operative with intra-operative images (e.g., magnetic resonance [MR] with ultrasound [US] images), as well as the on-screen visualization of procedures in progress. In so doing, US images can be employed as a template to which pre-operative images can be registered, to correct for anatomical changes, to provide live-image feedback, and consequently to improve confidence when making resection margin decisions near eloquent regions during tumour surgery.

In spite of the potential for tracked ultrasound to improve many neurosurgical procedures ...


Robust Feedback Control Based On Low Order Models With Uncertainty Estimation For A Class Of Biomedical Problems, Hector Puebla, Miguel A. Gutierrez-Limon, Eliseo Hernandez-Martinez, Alejandra Velasco-Perez 2016 Universidad Autonoma Metropolitana

Robust Feedback Control Based On Low Order Models With Uncertainty Estimation For A Class Of Biomedical Problems, Hector Puebla, Miguel A. Gutierrez-Limon, Eliseo Hernandez-Martinez, Alejandra Velasco-Perez

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Surface Engineering Of Titanium Alloy To Stimulate The Bone Regeneration, Yubin Meng, Zhenduo Cui, Zhaoyang Li, Xue Li, Jin Zhao, Xubo Yuan, Xianjin Yang 2016 Tianjin University

Surface Engineering Of Titanium Alloy To Stimulate The Bone Regeneration, Yubin Meng, Zhenduo Cui, Zhaoyang Li, Xue Li, Jin Zhao, Xubo Yuan, Xianjin Yang

The 8th International Conference on Physical and Numerical Simulation of Materials Processing

No abstract provided.


Fluorescent Materials Design At Nanoscale For Biomedical Photonics In Near Infrared Window, Kohei Soga, Masao Kamimura 2016 Tokyo University of Science

Fluorescent Materials Design At Nanoscale For Biomedical Photonics In Near Infrared Window, Kohei Soga, Masao Kamimura

The 8th International Conference on Physical and Numerical Simulation of Materials Processing

No abstract provided.


Elbow Patients’ Data Collection And Analysis: An Examination Of Electromyography Healing Patterns, Raneem Haddara 2016 The University of Western Ontario

Elbow Patients’ Data Collection And Analysis: An Examination Of Electromyography Healing Patterns, Raneem Haddara

Electronic Thesis and Dissertation Repository

Musculoskeletal conditions are the most common cause of severe long-term pain and physical disability, accounting for the highest disability costs of about $17 billion yearly. To provide better rehabilitation tactics, the knowledge gap between injuries and their healing mechanisms needs to be addressed. The use of electromyography (EMG) is very popular in detecting neuromuscular diseases or nerve lesions; however, there is limited knowledge available for quantifying healing patterns of EMG in orthopedic patients who have injured their joints, muscles, or bones. In order to quantify the progress of orthopedic patients and assess their neuromuscular health and muscle synergy patterns, EMG ...


Stem Cell Based Tissue Engineering And Regenerative Medicine: A Review Focusing On Adult Stem Cells, Jordan Greenberg, Veronica R. Fortino, Daniel Pelaez, Herman S. Cheung 2016 University of Miami

Stem Cell Based Tissue Engineering And Regenerative Medicine: A Review Focusing On Adult Stem Cells, Jordan Greenberg, Veronica R. Fortino, Daniel Pelaez, Herman S. Cheung

Veronica Fortino

Tissue engineering has emerged as a field that attempts to harness the bodies' own developmental and repair features to treat diseases and illnesses. Many of these illnesses are caused by necrosis or loss of functionality of complete organs or specific cell types. Early discoveries in embryonic stem cells fueled a wave of research that led to claims about possibly regenerating nonfunctioning organs. Although we are still far away from being able to grow functional organs in a Petri dish, the field continues to progress forward, and new clinical trials have been approved for using both embryonic and adult stem cell ...


Progress Of Mesenchymal Stem Cell Therapy For Neural And Retinal Diseases, Tsz Kin Ng, Veronica R. Fortino, Daniel Pelaez, Herman S. Cheung 2016 The Chinese University of Hong Kong

Progress Of Mesenchymal Stem Cell Therapy For Neural And Retinal Diseases, Tsz Kin Ng, Veronica R. Fortino, Daniel Pelaez, Herman S. Cheung

Veronica Fortino

Complex circuitry and limited regenerative power make central nervous system (CNS) disorders the most challenging and difficult for functional repair. With elusive disease mechanisms, traditional surgical and medical interventions merely slow down the progression of the neurodegenerative diseases. However, the number of neurons still diminishes in many patients. Recently, stem cell therapy has been proposed as a viable option. Mesenchymal stem cells (MSCs), a widely-studied human adult stem cell population, have been discovered for more than 20 years. MSCs have been found all over the body and can be conveniently obtained from different accessible tissues: bone marrow, blood, and adipose ...


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