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Biomedical Engineering and Bioengineering Commons

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Determination Of Anti-Fibrotic Effects Of Possible Scar-Collagen Antagonists On Tgf-Β1 Treated Dermal Fibroblasts, Janelle DeJong 2017 Dominican University of California

Determination Of Anti-Fibrotic Effects Of Possible Scar-Collagen Antagonists On Tgf-Β1 Treated Dermal Fibroblasts, Janelle Dejong

Scholarly & Creative Works Conference 2017

High levels of collagen being produced by cells in response to wounding is scarring. Scarring, or fibrosis, is a major medical science problem because of the lack of functionality of the affected organ. To reenact collagen levels during scarring, primary dermal fibroblasts were treated with TGF-β1 before the addition of test compounds. Transforming growth factor beta I (TGF-β1), a cytokine, is a known inducer of scar collagen production. Anti-fibrotic effects of test compounds were screened and evaluated in vitro by measuring amounts of collagen produced at the protein level. To measure secreted collagen as part of the extra-cellular ...


Oculomotor Neurocircuitry, A Structural Connectivity Study Of Infantile Nystagmus Syndrome, Nasser H. Kashou, Angelica R. Zampini 2017 Wright State University - Main Campus

Oculomotor Neurocircuitry, A Structural Connectivity Study Of Infantile Nystagmus Syndrome, Nasser H. Kashou, Angelica R. Zampini

Nasser H. Kashou

Infantile Nystagmus Syndrome (INS) is one of the leading causes of significant vision loss in children and affects about 1 in 1000 to 6000 births. In the present study, we are the first to investigate the structural pathways of patients and controls using diffusion tensor imaging (DTI). Specifically, three female INS patients from the same family were scanned, two sisters and a mother. Six regions of interest (ROIs) were created manually to analyze the number of tracks. Additionally, three ROI masks were analyzed using TBSS (Tract-Based Spatial Statistics). The number of fiber tracks was reduced in INS subjects, compared to ...


A Novel Hybrid Imaging System To Aid In Surgical Decision Making, Lawrence Yip, Madeleine Van De Kleut, Ivan Kosik, Astrid Chamson-Reig, Jeffrey JL Carson 2017 Western University

A Novel Hybrid Imaging System To Aid In Surgical Decision Making, Lawrence Yip, Madeleine Van De Kleut, Ivan Kosik, Astrid Chamson-Reig, Jeffrey Jl Carson

Western Research Forum

Background:

Breast cancer accounts for 25% of all cancer cases among women. In breast-conserving surgery, a common treatment, the tumour is excised with a healthy tissue margin. However, detection of the margin can be difficult. Current techniques to guide excision are often insufficient, and re-excision can occur up to 25% of the time.

Methods:

Photoacoustic imaging is a hybrid imaging modality that combines the advantages of optical imaging and ultrasound while using safe non-ionizing light. This project involves the development of a novel imaging system with a new scanner design to overcome common limitations and provide images to aid in ...


Validation Of Postural Sway Measurements Using Wii Balance Board, Zachary Meade 2017 University of Nebraska Omaha

Validation Of Postural Sway Measurements Using Wii Balance Board, Zachary Meade

Student Research and Creative Activity Fair

Standing balance measurements, such as postural sway, are vital for determining functional ability, risk of falling and recovery of injuries. Often the need to collect data outside of the typical clinical or research setting arises. However, obtaining these measurements outside of a laboratory setting can be very difficult, as the mobility of a laboratory-grade force plate (FP) is minimal, and its cost can be upwards of $20,000. The purpose of this study is to create a cheaper alternative by validating the Wii Balance Board’s (WBB; Nintendo, Redmond, Washington, USA) ability to measure postural sway patterns. The WBB can ...


On Utilizing Big Data To Assess Health Levels, Elham Rastegari 2017 University of Nebraska at Omaha

On Utilizing Big Data To Assess Health Levels, Elham Rastegari

Student Research and Creative Activity Fair

The general relationship between mobility/gait patterns and health conditions, has been established by many research studies. Gait patterns have been used in predicting fall incidents, assessing the movement of people with Parkinson disease and assessing gait characteristics of patients with major depression. However, not much has been reported in terms of how to utilize mobility data along with gait patterns to assess health levels and to identify early stages of certain diseases or conditions that impact mobility/gait patterns. In this project, we propose to develop a population analysis system based on recent Big Data technologies that relies on ...


Peak Vertical Ground Reaction Force & Stance Phase Time To Assess Post-Tka Interlimb Asymmetry, Abderrahman Ouattas 2017 University of Nebraska at Omaha

Peak Vertical Ground Reaction Force & Stance Phase Time To Assess Post-Tka Interlimb Asymmetry, Abderrahman Ouattas

Student Research and Creative Activity Fair

In the US, more than 500,000 TKA surgeries are performed annually, to which 97% of those are led by OA1. Although knee pain is diminished post-TKA, unilateral efficiency and walking asymmetry is still unresolved several years after the surgery2. In fact, within a minimum of 10 years after the primary TKA, almost 50% of patients undergo a secondary TKA on the contralateral limb due to OA progression3. The purpose of this study was to determine if post-Total Knee Arthroplasty peak vertical ground reaction force (pVGRF) asymmetry could be identified using stance phase time differences between the ...


Acl Reconstruction Results In Alterations For Force Control Variability During Multidirectional Force Production, Amelia S. Lanier 2017 University of Nebraska at Omaha

Acl Reconstruction Results In Alterations For Force Control Variability During Multidirectional Force Production, Amelia S. Lanier

Student Research and Creative Activity Fair

After anterior cruciate ligament (ACL) rupture most will undergo reconstructive surgery. Within the first year after surgery 25% of patients will re-tear their ACL. Most of those injured attempt to return to sports which include running and cutting. The ability to produce appropriate ground reaction forces may be crucial for the successful return to sports without re-injury. Understanding stability of multidirectional ground reaction force (mGRF) production in healthy and ACL reconstructed (ACL-r) patients can lend insight to the high instance of re-injury. Typically, stability has been measured using linear analyses, but these analyses cannot capture the subtle time varying changes ...


The Effects Of Walking Speed On Gait Propulsion When Wearing An Ankle-Foot Orthosis, Alli Kalina 2017 University of Nebraska at Omaha

The Effects Of Walking Speed On Gait Propulsion When Wearing An Ankle-Foot Orthosis, Alli Kalina

Student Research and Creative Activity Fair

Peripheral artery disease (PAD) is a cardiovascular disease that results from blockage of one or more arteries in the lower extremity. Often, patients with PAD have reduced ability to push off with the foot at the end of the gait cycle. When walking, the ankle contributes the majority of the power to propel the body into the next step. An ankle-foot orthosis (AFO) is a device that aids in ankle propulsion by increasing the energy return, thus decreasing the ankle deficit in pathological individuals. The purpose is to investigate the effect of walking speed on ankle propulsion during walking. Subjects ...


Investigating The Role Of Mechanosensitive Ion Channels In Urothelial Cell Pressure Mechanotransduction, Shawn Olsen 2017 Clemson University

Investigating The Role Of Mechanosensitive Ion Channels In Urothelial Cell Pressure Mechanotransduction, Shawn Olsen

Shawn Olsen

Overactive bladder (OAB) is a bladder disorder that is characterized by bladder storage symptoms of urgency with or without urge incontinence, frequency, nocturia, and, as of 2003, affected approximately 16.5% of adults in the United States with an annual treatment cost of over $65 billion. While therapies are available to mitigate the symptoms of OAB, there are no treatments for the cause of OAB, due to the lack of understanding of the etiology of the disorder. Recent research has provided evidence that the bladder urothelium is not just a passive barrier, but is also sensitive to various chemical and ...


Compare And Investigate The Evolutionary Optimization Algorithms Insect.Pdf, Ata Jahangir Moshayedi 2017 University of Pune

Compare And Investigate The Evolutionary Optimization Algorithms Insect.Pdf, Ata Jahangir Moshayedi

Ata Jahangir Moshayedi

Today, SI group intelligence and inspired computations from the nature have attracted considerable amount of attention, especially in optimization, computational intelligence and computer fields.
Based on algorithms SI such as ant algorithm, bee algorithm, termite algorithm, firefly algorithm and so on provide way more advantages compared with ordinary algorithms. Currently, inspired heuristic algorithms from the nature among other algorithms and computational intelligence are employed for
optimization. Optimization is the ultimate goal of many applications such as engineering, industrial designing, etc. The aim of optimization is to minimize energy consumption and costs,
maximize profits, output, performance, efficiency and so on. Present ...


Estimation Of The Centre Of Mass From Motion Capture And Force Plate Recordings: A Study On The Elderly, Sebastien Cotton, Michele Vanoncini, Philippe Fraisse, Nacim Ramdani, Emel Demircan, Andrew P. Murray, Thierry Keller 2017 Universite de Montpellier II

Estimation Of The Centre Of Mass From Motion Capture And Force Plate Recordings: A Study On The Elderly, Sebastien Cotton, Michele Vanoncini, Philippe Fraisse, Nacim Ramdani, Emel Demircan, Andrew P. Murray, Thierry Keller

Andrew P. Murray

The estimation of the centre of mass position in humans is usually based on biomechanical models developed from anthropometric tables. This method can potentially introduce errors in studies involving elderly people, since the ageing process is typically associated with a modification of the distribution of the body mass. In this paper, an alternative technique is proposed, and evaluated with an experimental study on 9 elderly volunteers. The technique is based on a virtual chain, identified from experimental data and locating the subject's centre of mass. Its configuration defines the location of the centre of mass, and is a function ...


A Review Of The Evolutionary Optimization Algorithms Inspired From.Pdf, Ata Jahangir Moshayedi, Mohammad Amin Iravani Rad, Saeed Safarafard 2017 University of Pune

A Review Of The Evolutionary Optimization Algorithms Inspired From.Pdf, Ata Jahangir Moshayedi, Mohammad Amin Iravani Rad, Saeed Safarafard

Ata Jahangir Moshayedi

n the past two decades, nature inspired optimization algorithm along with classical methods have gained noticeable accomplishments. Optimization, which had led to various types of algorithm design has been one of the signification areas of research in recent decades. In most engineering issues one
encounters with objective function which needs to be optimized. In group methods, factors work with one another and the collaborative behavior of all factors leads to a convergence. Now there are various ways or methods to reach optimization, however, undoubtedly, each has its own pitfalls. The present
study investigates mammal algorithms such as wolves, bats and ...


Design Of A Practice Fundamentals Of Engineering Exam For Undergraduate Biomedical Engineering Students, Matthew J. A. Rickard, Seung-Jae Kim, Mark Gordon, Seong Deok Kong, Peter Havrisik 2017 California Baptist University

Design Of A Practice Fundamentals Of Engineering Exam For Undergraduate Biomedical Engineering Students, Matthew J. A. Rickard, Seung-Jae Kim, Mark Gordon, Seong Deok Kong, Peter Havrisik

Biomedical Engineering Western Regional Conference

KEYWORDS:

Biomedical Engineering Undergraduate Bioengineering Fundamentals Exam FE standardized test


Differentiation Of Kidney Progenitors Using Induced Pluripotent Stem Cells And Conditioned Media Of Renal Cortical Tubular Epithelial Cells, Matthew Nielsen 3644978, Steven Passey, Maxwell Beers, Alonzo Cook 2017 Brigham Young University - Provo

Differentiation Of Kidney Progenitors Using Induced Pluripotent Stem Cells And Conditioned Media Of Renal Cortical Tubular Epithelial Cells, Matthew Nielsen 3644978, Steven Passey, Maxwell Beers, Alonzo Cook

Biomedical Engineering Western Regional Conference

No abstract provided.


Dual Mechanism For Toughening And Sustained Aminoglycoside Elution From A Polyphosphate Hydrogel, Dwight D. Lane, Russell J. Stewart PhD 2017 University of Utah

Dual Mechanism For Toughening And Sustained Aminoglycoside Elution From A Polyphosphate Hydrogel, Dwight D. Lane, Russell J. Stewart Phd

Biomedical Engineering Western Regional Conference

No abstract provided.


Redesign Of Computer Keyboards For Hospital And Consumer Use, Kent Williams, Brian Jensen, Anton Bowden 2017 Brigham Young University - Provo

Redesign Of Computer Keyboards For Hospital And Consumer Use, Kent Williams, Brian Jensen, Anton Bowden

Biomedical Engineering Western Regional Conference

Application of carbon nanotube coatings to computer keyboards in order to reduce the spread of bacteria in hospitals and homes.

Keywords: carbon nanotube, bacteria, antimicrobial, keyboard, design, MRSA, biofilm


Soft-Tissue Artifact Compensation For Electromagnetic Motion Capture, George T. Dickinson, Steven K. Charles 2017 Brigham Young University - Provo

Soft-Tissue Artifact Compensation For Electromagnetic Motion Capture, George T. Dickinson, Steven K. Charles

Biomedical Engineering Western Regional Conference

This purpose of this study is to develop a soft-tissue artifact compensation algorithm for the upper arm using electromagnetic motion capture systems that can be implemented in a wide range of applications. This study focuses on compensation of humeral axial rotation and forearm axial rotation.


The Sub-Chronic Vascular Response To Water-Borne Embolic Coacervates., Joshua P. Jones, Monika Sima, Russell J. Stewart 2017 University of Utah

The Sub-Chronic Vascular Response To Water-Borne Embolic Coacervates., Joshua P. Jones, Monika Sima, Russell J. Stewart

Biomedical Engineering Western Regional Conference

Water-borne coacervates that solidify in response to decreasing ionic strength have been developed as an agent for small vessel transcatheter embolization. Here, the sub-chronic vascular response to these agents will be presented. Embolic coacervates demonstrated a benign foreign body response, which supported tissue ingrowth and stabilized vessel occlusion out to 28 days. As with other liquid embolics, occlusion is dependent upon mechanical obstruction of the vessel and native thrombus. Over time, the thrombus becomes more organized by fibroblasts. Continuation of the processes seen at 28 days will likely result in fibrous encapsulation of the embolic coacervate, further stabilizing the occlusion.


Serum Comp And The Inflammatory Environment Of The Knee Before And After Exercise-Induced Load, Alyssa Evans, Robert D. Hyldahl, Sarah T. Ridge, Sunku Kwon, Ty J. Hopkins, Eric R. Robinson, Matthew K. Seeley 2017 Brigham Young University

Serum Comp And The Inflammatory Environment Of The Knee Before And After Exercise-Induced Load, Alyssa Evans, Robert D. Hyldahl, Sarah T. Ridge, Sunku Kwon, Ty J. Hopkins, Eric R. Robinson, Matthew K. Seeley

Biomedical Engineering Western Regional Conference

The purpose of this study was to determine how accurately serum COMP represents inflammatory cytokine levels, within the knee, before and after exercise.

Cytokines included: GM-CSF, IFNa2, IL-10, IL-12p40, IL-13, IL-15, IL-1ra, IL1b, IL1a, IL-4, IL-6, IL-8, IP-10, MCP-1, MIP-1a, MIP-1b and IL-17.


Differentiation And Containment Of Derived Pancreatic Beta Cells, Caden Duffy, Alonzo Cook Ph.D. 2017 Brigham Young University - Provo

Differentiation And Containment Of Derived Pancreatic Beta Cells, Caden Duffy, Alonzo Cook Ph.D.

Biomedical Engineering Western Regional Conference

Currently, the only permanent cure for Type 1 Diabetes is a pancreatic or islet transplant. With the shortage of donors, we are progressing research towards alternative therapies by differentiating induced pluripotent stem cells into derived pancreatic β-cells that can be transplanted and used as treatment for Type 1 Diabetes. We are investigating methods to increase the yield of fully derived, insulin producing pancreatic β-cells and are additionally researching the use of hydrophilized expanded polytetrafluoroethylene for use in cell containment devices. These devices could offer a future alternative for islet transplantation in human patients.


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