Biomedical Engineering and Bioengineering Commons^™

Evaluation Of Thermophile Algae In Horizontal Photo-Bioreactor, Olivier Schmied

BioResource and Agricultural Engineering

No abstract provided.

Investigating The Reproducibility Of The Current Bvm Protocol, Corey Gross

Biomedical Eng/General Eng.

Coronary Artery Disease (CAD) is responsible for 1 death every minute in the US. Angioplasty with the implantation of stents is a common treatment method for CAD. Although there is a variety of stents currently on the market, there is still a need to develop new types for different pathologic conditions. Preliminary assessment of the physiological response to new stents is needed as they are being developed. The FDA approval process implemented today is a long, tedious path with a range of testing methods that include static in vitro testing and high-cost animal testing. Tissue engineered blood vessels have been ...

Finite Element Analysis Of The Nerve Cuff To Determine Usability And Stress Analysis During Regular Use, Vivek Machhi

Biomedical Eng/General Eng.

To determine the stress analysis on the Nerve Cuff by MicroProbes, a finite element analysis was conducted. A simplified model was created in Solid Works using the geometry of the basic model of the nerve cuff. The solid model was then imported into Abaqus and the appropriate materials, boundary conditions, and loads were designated. Initially a tensile test simulation was conducted using a tensile force of 2.87 Newtons. The maximum stress experienced with this tensile force was 8.225 MPa which was greater than the ultimate tensile strength of 5.5 MPa of Silicone. Both the actual tensile test ...

Guidance System, Kayaking For The Visually Impaired, D. Ryan Kirtland, Ryan Phife, William Gardner, Amy Johnson

Biomedical Eng/General Eng.

Quality Life Plus is working with Team River Runner to develop an assistive guidance system for veterans who want to remain active by kayaking, after sustaining an injury that impairs vision. This system allows these veterans to complete a slalom speed race independent of a personal guide in the water. The system incorporates 3 stations that each contain a speaker connected to a microcontroller system covered by a Pelican Case on a custom made buoy. During the slalom race, a kayaker will travel from shore towards buoy #1 as it omits sound from the speaker. As the kayaker moves around ...

Design Of An Experimental Approach To Study The Growth Of Biofilm On Polymethylmethacrylate, Eireen S. Escalona

Biomedical Eng/General Eng.

Biofilms are present in virtually every solid-liquid contact surface and are partially responsible for some diseases and water cleaning. They are a community of a variety of organisms that live symbiotically and are bound together by extracellular polymeric substances, or EPS. Biofilms go through five stages of development. These include initial and irreversible attachments, maturations I and II, and dispersion. In the dental world, biofilms are often associated with mouth infections including dental caries, gingivitis and periodontitis. Elderly denture wearers are susceptible to the pathogen-causing bacteria associated with these diseases, particularly those who have Alzheimer's disease or other forms ...

Computational Modeling To Evaluate Helical Electrode Designs For Use In Vagus Nerve Stimulation, Anthony W. Cowley

Master's Theses and Project Reports

An estimated 0.5% of world’s population has been diagnosed with epilepsy. Of these patients 20-30% will be unable to achieve seizure control with anti-epileptic drugs. Vagus nerve stimulation (VNS) may be an appropriate treatment option for some patients with pharmaceutically refractory, partial-onset seizures.

VNS therapy uses a helical electrode to interface between the implantable pulse generator and the vagus nerve. While there have been several studies related to the mechanical and electrical safety of such electrodes, little work has been done toward understanding the effectiveness of the helical electrode in nerve stimulation. A better understanding of the voltage ...

Development Of A Microchip-Based Flow Cytometer With Integrated Optics – Device Design, Fabrication, And Testing, Benjamin Watts

Open Access Dissertations and Theses

Lab-on-a-chip technologies have created a burgeoning number of new and novel devices designed to automate biological processes on-chip in an efficient and inexpensive format for far reaching point-of-care (POC) medicine and diagnostic treatments and for remote and on-line monitoring functions. This work designed a device that integrated advanced optical functionality on-chip with the microfluidics to relieve the reliance on traditional bulky and expensive free-space optics and a high-quality light source. The multimodal input beam was reshaped into an optimized geometry in the microchannel via a 2D system of lenses - improving the quality and reliability of detection through uniform detection of ...

Edwards Lifesciences - Skirt To Frame Attachment Manufacturing Aid, Samuel Joda, Cesar Grimaldo, Patrick Hutchinson

Mechanical Engineering

No abstract provided.

Evaluation Of The Anterior Talofibular And Calcaneofibular Ligament In Relation To Supination Ankle Sprains, Peter Tran

Biomedical Eng/General Eng.

Ankle injuries have always posed an issue to a number of athletes. Sports that involve running and jumping accumulate about 25% of injuries correlating to ankle sprains. In most ankle sprains the inversion (supination) of the ankle cause damage to lateral ligaments. The two most common lateral ligaments to experience damage are the anterior talofibular (ATFL) and calcaneofibular (CFL) ligaments. The methods of taping and ankle braces have allowed athletes to prevent recurring sprains from occurring. However, sprains can still occur even when one or both methods are applied. The purpose of each method is to restrict the range of ...

From Olin To India, Geetanjali Gubba

2013 Grand Challenge Scholars Program

This portfolio is a compilation of experiences related to the Grand Challenges area of Engineering Better Medicines. I spent six months working in India for a startup called Embrace Innovations to develop low cost infant warmers to help save millions on babies’ lives in developing area. With my interdisciplinary background from Olin in entrepreneurship, user-centric design, and mechanical engineering, I was able to apply myself in a global context and learn about the problems in the world that engineers like me can tackle and solve. In this set of reflections, I recount a summary of my experiences over the past ...

Effects Of Ovariectomy And Anatomical Location On Osteonal Encroachment In Adult Cortical Ovine Bone, Paige Brell Ryan

Master's Theses and Project Reports

The purpose of this study is to further quantify adult ovine ovariectomized bone for new remodeling characteristics to obtain a better understanding of how remodeling is occurring and the effectiveness of this animal model for the study of postmenopausal osteoporosis. Postmenopausal osteoporosis is a major health concern and animal models to test new treatment options are needed. The ovine model is a good option because the ewes undergo Haversian remodeling, are a large sized animal, and have a similar hormone profile to humans. Ewes, however, do not undergo a natural menopause, so an ovariectomy surgery was conducted in the sheep ...

On The Development Of A Dynamic Contrast-Enhanced Near-Infrared Technique To Measure Cerebral Blood Flow In The Neurocritical Care Unit, Jonathan T. Elliott

University of Western Ontario - Electronic Thesis and Dissertation Repository

A dynamic contrast-enhanced (DCE) near-infrared (NIR) method to measure cerebral blood flow (CBF) in the neurocritical care unit (NCU) is described. A primary concern in managing patients with acquired brain injury (ABI) is onset of delayed ischemic injury (DII) caused by complications during the days to weeks following the initial insult, resulting in reduced CBF and impaired oxygen delivery.

The development of a safe, portable, and quantitative DCE-NIR method for measuring CBF in NCU patients is addressed by focusing on four main areas: designing a clinically compatible instrument, developing an appropriate analytical framework, creating a relevant ABI animal model, and ...

Storage And Loss Moduli Of Bone In Osteogenesis Imperfecta (Oi), Carolyne Albert, John Jameson, Jeffrey Toth, Peter Smith, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

No abstract provided.

A Biomechanical Model For The Validation Of Modular Control In Balance, S. Piazza, M. Mansouri, D. Torricelli, Jeffrey A. Reinbolt, J. L. Pons

Jeffrey A. Reinbolt

No abstract provided.

Muscle Force Estimates During The Weight-Acceptance Phase Of Single-Leg Jump Landing, K. D. Morgan, C. J. Donnelly, Jeffrey A. Reinbolt

Jeffrey A. Reinbolt

No abstract provided.

The Use Of A Platform For Dynamic Simulation Of Movement: Application To Balance Recovery, M. B. Mansouri, A. E. Clark, Jeffrey A. Reinbolt

Jeffrey A. Reinbolt

No abstract provided.

Using Principal Components Analysis To Model Muscle Force Contribution In Acl Injury, K. D. Morgan, M. H. Morgan, C. B. Donnelly, Jeffrey A. Reinbolt

Jeffrey A. Reinbolt

No abstract provided.

Biomedical Photoacoustic Imaging Using Gas-Coupled Laser Acoustic Detection, Jami L. Johnson

Student Research Initiatives

Several detection methods have been explored for photoacoustic and ultrasound imaging of biological tissues. Piezoelectric transducers are commonly used, which require contact with the sample and have limiting bandwidth characteristics. Interferometry detection exhibits improved bandwidth characteristics and resolution, yet generally require complicated optics and the incorporation of a contacting reflective medium. Here, we report the use of a noncontact photoacoustic and laser-ultrasound imaging system that does not require the use of a reflective layer. A simple, robust technique known as gas-coupled laser acoustic detection is used, which has previously been applied to composite material evaluation. This technique has the potential ...

Capstone Design Courses, Part Ii: Preparing Biomedical Engineers For The Real World, Jay R. Goldberg

Books by Marquette University Faculty

The biomedical engineering senior capstone design course is probably the most important course taken by undergraduate biomedical engineering students. It provides them with the opportunity to apply what they have learned in previous years, develop their communication, teamwork, project management, and design skills, and learn about the product development process. It prepares students for professional practice and serves as a preview of what it will be like to work as a biomedical engineer. The capstone design experience can change the way engineering students think about technology, themselves, society, and the world around them. It can make them aware of their ...

Surface Modification Of Polydimethylsiloxane With A Covalent Antithrombin-Heparin Complex For Blood Contacting Applications, Jennifer M. Leung

Open Access Dissertations and Theses

Medical devices used for diagnosis and treatment often involve the exposure of the patient’s blood to biomaterials that are foreign to the body, and blood-material contact may trigger coagulation and lead to thrombotic complications. Therefore, the risk of thrombosis and the issue of blood compatibility are limitations in the development of biomaterials for blood-contacting applications. The objective of this research was to develop a dual strategy for surface modification of polydimethylsiloxane (PDMS) to prevent thrombosis by (1) grafting polyethylene glycol (PEG) to inhibit non-specific protein adsorption, and (2) covalently attaching an antithrombin-heparin (ATH) covalent complex to the distal end ...