Injectable, Magnetic Plum Pudding Hydrogel Composites For Controlled Pulsatile Drug Release, Danielle Maitland

Open Access Dissertations and Theses

Injectable, in-situ gelling magnetic plum pudding hydrogel composites were fabricated by entrapping superparamagnetic iron oxide nanoparticles (SPIONs) and thermosensitive N-isopropylacrylamide (NIPAM)-co–N-isopropylmethacrylamide (NIPMAM) microgels in a pNIPAM-hydrazide/carbohydrate-aldehyde hydrogel matrix. The resulting composites exhibited significant, repeatable pulsatile release of 4 kDa FITC-dextran upon exposure to an alternating magnetic field. The pulsatile release from the composites could be controlled by altering the volume phase transition temperatures of the microgel particles (with VPTTs over 37°C corresponding to improved pulsatile release) and changing the microgel content of the composite (with higher microgel content corresponding to higher pulsatile release). By changing the ...

A Multi-Well Concentration Gradient Drug Delivery Microfluidic Device For High-Content And High-Throughput Screening, Michael M. Nelson

Open Access Dissertations and Theses

A microfluidic device capable of drug delivery to multiple wells in a concentration gradient was designed for automated high content and high throughput screening. The design was proposed to utilize a nanoporous polycarbonate membrane to spatially and temporally control drug dosage from the microchannels below to the wells above. Microchannels were to hold to the drugs or reagents, while wells were to culture cells. An array of 16 wells was to fit in the equivalent area of a single well of a 96 well plate. Two simpler devices were created to validate electrokinetic drug delivery to a single well and ...

Implementation And Validation Of Aortic Remodeling In Hypertensive Rats, Shijia Zhao, Linxia Gu

Mechanical & Materials Engineering Faculty Publications

A computational framework was implemented and validated to better understand the hypertensive artery remodeling in both geometric dimensions and material properties. Integrating the stress-modulated remodeling equations into commercial finite element codes allows a better control and visualization of local mechanical parameters. Both arterial thickening and stiffening effects were captured and visualized. An adaptive material remodeling strategy combined with the element birth and death techniques for the geometrical growth were implemented. The numerically predicted remodeling results in terms of the wall thickness, inner diameter, and the ratio of elastin to collagen content of the artery were compared with and fine-tuned by ...

Some Analytic And Finite Element Solutions Of The Graphene Euler Beam, Dongming Wei

Dongming Wei

No abstract provided.

Experimental And Numerical Investigation Of The Mechanism Of Blast Wave Transmission Through A Surrogate Head, Yi Hua, Praveen Akula, Linxia Gu, Jeff Berg, Carl A. Nelson

Mechanical & Materials Engineering Faculty Publications

This work is to develop an experiment-validated numerical model to elucidate the wave transmission mechanisms through a surrogate head under blast loading. Repeated shock tube tests were conducted on a surrogate head, i.e., water-filled polycarbonate shell. Surface strain on the skull simulant and pressure inside the brain simulant were recorded at multiple locations. A numerical model was developed to capture the shock wave propagation within the shock tube and the fluid-structure interaction between the shock wave and the surrogate head. The obtained numerical results were compared with the experimental measurements. The experiment-validated numerical model was then used to further ...

Frontal White Matter Integrity In Adults With Down Syndrome With And Without Dementia, David K. Powell, Allison Caban-Holt, Greg A. Jicha, William C. Robertson, Roberta Davis, Brian T. Gold, Frederick A. Schmitt, Elizabeth Head

Magnetic Resonance Imaging and Spectroscopy Center Faculty Publications

Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease after the age of 40 years. To detect white matter (WM) changes in the brain linked to dementia, fractional anisotropy (FA) from diffusion tensor imaging was used. We hypothesized that adults with DS without dementia (DS n = 10), DS with dementia (DSAD n = 10) and age matched non-DS subjects (CTL n = 10) would show differential levels of FA and an association with scores from the Brief Praxis Test and the Severe Impairment Battery. WM integrity differences in DS compared with CTL were found predominantly in the ...

Preliminary Test Of A Real-Time, Interactive Silent Speech Interface Based On Electromagnetic Articulograph, Jun Wang, Ashok Samal, Jordan R. Green

CSE Conference and Workshop Papers

A silent speech interface (SSI) maps articulatory movement data to speech output. Although still in experimental stages, silent speech interfaces hold significant potential for facilitating oral communication in persons after laryngectomy or with other severe voice impairments. Despite the recent efforts on silent speech recognition algorithm development using offline data analysis, online test of SSIs have rarely been conducted. In this paper, we present a preliminary, online test of a real-time, interactive SSI based on electromagnetic motion tracking. The SSI played back synthesized speech sounds in response to the user’s tongue and lip movements. Three English talkers participated in ...

Mathematically Modeling Fetal Electrocardiograms, Samuel Estes, Kiersten Utsey, Erick Kalobwe

Pursuit - The Journal of Undergraduate Research at the University of Tennessee

Abstract

Some of the most common and fatal birth defects are those related to the heart. In adults, possible heart conditions are often identified through the use of an electrocardiogram (ECG). However, due to the presence of other signals and noise in the recording, fetal eletrocardiography has not yet proven effective in diagnosing these defects. This paper develops a mathematical model of three-dimensional heart vector trajectories, which was used to generate synthetic maternal and fetal ECG signals. The dipole model is a useful simplification in which the electrical activity of the heart is viewed as a single time-varying vector originating ...

Image-Based Registration Methods For Quantification And Compensation Of Prostate Motion During Trans-Rectal Ultrasound (Trus)-Guided Biopsy, Tharindu De Silva

University of Western Ontario - Electronic Thesis and Dissertation Repository

Prostate biopsy is the clinical standard for cancer diagnosis and is typically performed under two-dimensional (2D) transrectal ultrasound (TRUS) for needle guidance. Unfortunately, most early stage prostate cancers are not visible on ultrasound and the procedure suffers from high false negative rates due to the lack of visible targets. Fusion of pre-biopsy MRI to 3D TRUS for targeted biopsy could improve cancer detection rates and volume of tumor sampled. In MRI-TRUS fusion biopsy systems, patient or prostate motion during the procedure causes misalignments in the MR targets mapped to the live 2D TRUS images, limiting the targeting accuracy of the ...

Sonar For The Visually Impaired, Anastasia Newark, Edwin Ng, Scott Terhorst

Biomedical Eng/General Eng.

There are currently no inexpensive assistive devices that allow the visually impaired detect low hanging objects that are above waist height and may cause injury, such as a rope or tree branch. The challenge presented to the team by the Quality of Life Plus Lab (QL+) was to develop a Sonar Cane device that attaches to a traditional white cane to address this problem. This device must be lightweight, inexpensive to manufacture, have a long battery life, and accurately detect obstacles to prevent user injury.

Team Omnimouse, Derek J. Halman, Josh B. Porter, Steven A. Silver, Ian S. Stemper

Computer Engineering

INFORMATION, DATA, FIGURES AND DRAWINGS EMBODIED IN THIS DOCUMENT ARE STRICTLY CONFIDENTIAL AND ARE SUPPLIED ON THE UNDERSTANDING THAT THEY WILL NOT BE DISCLOSED TO THIRD PARTIES WITHOUT THE PRIOR WRITTEN CONSENT OF QUALITY OF LIFE PLUS.

Alternate Computer Input Device For Individuals With Quadriplegia, Tobais Elder, Michelle Martinez, David Sylvester

Biomedical Eng/General Eng.

This project details the design development of an alternative computer input system that allows a person with quadriplegia to move a computer's cursor and activate left and right click button inputs. After researching and analyzing possible solutions, an end design was chosen that most appropriately satisfied all user requirements and engineering specifications. This final design employs a head mounted Inertial Measurement Unit (IMU) with 9 DoF (Degrees of Freedom) to track head movements and correlate these motions to computer cursor movements. A Sip-Puff Transducer monitors and interprets a user's application of negative and positive air pressure differentials to ...

Characterizing The Reproducibility Of The Properties Of Electrospun Poly(D,L-Lactide-Co-Glycolide) Scaffolds For Tissue-Engineered Blood Vessel Mimics, Toni M. Pipes

Master's Theses and Project Reports

“Blood vessel mimics” (BVMs) are tissue-engineered constructs that serve as in vitro preclinical testing models for intravascular devices. The Cal Poly Tissue Engineering lab specifically uses BVMs to test the cellular response to stent implantation. PLGA scaffolds are electrospun in-house using the current “Standard Protocol” and used as the framework for these constructs. The performance of BVMs greatly depends on material and mechanical properties of the scaffolds. It is desirable to create BVMs with reproducible properties so that they can be consistent models that ultimately generate more reliable results for intravascular device testing. Reproducibility stems from the consistency of the ...

Neuromodulation: Action Potential Modeling, Vladimir Ruzov

Master's Theses and Project Reports

There have been many different studies performed in order to examine various properties of neurons. One of the most important properties of neurons is an ability to originate and propagate action potential. The action potential is a source of communication between different neural structures located in different anatomical regions. Many different studies use modeling to describe the action potential and its properties. These models mathematically describe physical properties of neurons and analyze and explain biological and electrochemical processes such as action potential initiation and propagation. Therefore, one of the most important functions of neurons is an ability to provide communication ...

The Effect Of Fiber Depth On The Estimation Of Peripheral Nerve Fiber Diameter Using Group Delay And Simulated Annealing Optimization, Nam Tran

Master's Theses and Project Reports

Peripheral neuropathy refers to diseases of or injuries to the peripheral nerves in the human body. The damage can interfere with the vital connection between the central nervous system and other parts of the body, and can significantly reduce the quality of life of those affected. In the US, approximately between 15 and 20 million people over the age of 40 have some forms of peripheral neuropathy. The diagnosis of peripheral neuropathy often requires an invasive operation such as a biopsy because different forms of peripheral neuropathy can affect different types of nerve fibers. There are non-invasive methods available to ...

Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes

Master's Theses and Project Reports

The American Cancer Society predicts that 1,665,540 people will be diagnosed with cancer, and 585,720 people will die from cancer in 2014. One of the most common types of cancer in the United States is skin cancer. Melanoma alone is predicted to account for 10,000 of the cancer related deaths in 2014. As a highly mobile and aggressive form of cancer, melanoma is difficult to fight once it has metastasized through the body. Early detection in such varieties of cancer is critical in improving survival rates in afflicted patients. Present methods of detection rely on visual ...

Fluid Flow-Induced Mesenchymal Stem Cell Migration: Role Of Fak And Rock Mechanosensors, Brandon D. Riehl

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

The study of mesenchymal stem cell (MSC) migration under mechanical stimulation conditions with investigation of the underlying molecular mechanism could lead to a better understanding and outcomes in stem cell-based regenerative medicine. MSCs having multipotent regenerative capability exist in niches in the bone marrow, muscle, vasculature, and in other tissues throughout the body, and their migration through tissues and vasculature for the repair of damaged tissue is a key process of cell and tissue homeostasis, remodeling, and regeneration. While cell migration in response to cytokines and other chemo-attractants is relatively well understood, little is revealed in regard to the effect ...

Mr To Ultrasound Registration For Image-Guided Prostate Biopsy, Yue Sun

University of Western Ontario - Electronic Thesis and Dissertation Repository

Transrectal ultrasound (TRUS) guided prostate biopsy is the standard approach for diagnosis of prostate cancer (PCa). However, due to the lack of image contrast of prostate tumors, it often results in false negatives. Magnetic Resonance Imaging (MRI) has been considered to be a promising imaging modality for noninvasive identification of PCa, since it can provide a high sensitivity and specificity for the detection of early stage PCa. Our main objective is to develop a registration method of 3D MR-TRUS images, allowing generation of volumetric 3D maps of targets identified in 3D MR images to be biopsied using 3D TRUS images ...

Comprehensive T Cell Antigen Discovery Using A Genomic Approach, Jessica Baker

Vaccine Technology IV

No abstract provided.

Nasopharyngeal Method For Selective Brain Cooling And Development Of A Time-Resolved Near-Infrared Technique To Monitor Brain Temperature And Oxidation Status During Hypothermia, Mohammad Fazel Bakhsheshi

University of Western Ontario - Electronic Thesis and Dissertation Repository

Mild hypothermia at 32-35^oC (HT) has been shown to be neuroprotective for neurological emergencies following severe head trauma, cardiac arrest and neonatal asphyxia. However, HT has not been widely deployed in clinical settings because: firstly, cooling the whole body below 33-34°C can induce severe complications; therefore, applying HT selectively to the brain could minimize adverse effects by maintaining core body temperature at normal level. Secondly, development of an effective and easy to implement selective brain cooling (SBC) technique, which can quickly induce brain hypothermia while avoiding complications from whole body cooling, remains a challenge. In this thesis ...