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Biomechanics and Biotransport Commons

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366 full-text articles. Page 1 of 17.

The Effect Of Radial And Ulnar Length Change On Distal Forearm Loading, Ahaoiza D. Isa 2017 The University of Western Ontario

The Effect Of Radial And Ulnar Length Change On Distal Forearm Loading, Ahaoiza D. Isa

Electronic Thesis and Dissertation Repository

The effect of distal radial and ulnar length change on forearm bone loading is not well understood during simulated dynamic wrist loading. This thesis presents two studies which investigate the effect of these length changes on distal forearm loading under simulated dynamic wrist motion. The first study investigates the effect of radial length change on axial loading at the distal radius and ulna and relationship between ulnar variance and distal forearm loading. The complex variation in axial loads in the distal radius and during length change and dynamic wrist motion were studied and discussed. There was no correlation between native ...


Intrinsic Regulators Of Actomyosin Contractility Engendering Pulsatile Behaviors, Qilin Yu, Jing Li, Taeyoon Kim 2017 Purdue University

Intrinsic Regulators Of Actomyosin Contractility Engendering Pulsatile Behaviors, Qilin Yu, Jing Li, Taeyoon Kim

The Summer Undergraduate Research Fellowship (SURF) Symposium

Actomyosin contractility regulates various biological processes including cell migration, muscle contraction, and tissue morphogenesis. Cell cortex underlying a membrane, which is a representative actomyosin network in eukaryote cells, exhibits dynamic contractile behaviors. Interestingly, the cell cortex shows reversible aggregation of actin and myosin called pulsatile contraction in diverse cellular phenomena, such as embryogenesis and tissue morphogenesis. While contractile behaviors have been studied in several in vitro experiments and computational studies, none of them demonstrated the pulsatile contraction of actomyosin networks observed in vivo. Here, we used an agent-based computational model based on Brownian dynamics to identify factors facilitating the pulsatile ...


Bacterial Motility And Its Role In Biofilm Formation, Clayton J. Culp, Arezoo M. Ardekani, Adib Ahmadzadegan 2017 Purdue University

Bacterial Motility And Its Role In Biofilm Formation, Clayton J. Culp, Arezoo M. Ardekani, Adib Ahmadzadegan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Bacterial biofilms are known to cause millions of dollars in damage in the medical industry per year via infection of central venous catheters, urinary catheters, and mechanical heart valves. Unfortunately, there are some characteristics of biofilm formation that are yet to be fully understood. Recently much work has been done to investigate the motility characteristics of bacteria with hopes of better understanding the phenomena of biofilm formation. Still, one of the least understood stages is bacterial attachment or adhesion, a process designed to anchor bacteria in an advantageous environment. Providing a better understanding of bacterial motility near solid interfaces will ...


Stretch Control Of Adipocyte Insulin Signaling, Tasneem Bouzid 2017 University of Nebraska - Lincoln

Stretch Control Of Adipocyte Insulin Signaling, Tasneem Bouzid

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Obesity and related metabolic disorders have reached global epidemic proportions in recent decades. Excess and hypertrophic adipose tissue has been implicated in the development of various pathological diseases and disorders including Type-2 diabetes mellitus (Type-2 DM). In addition to serving as energy storage for the body, evidence also suggests that adipose tissue behaves as an endocrine organ capable of secreting bioactive cytokines known as adipokines, which mediate insulin signaling pathways in various tissues. Physical exercise has been demonstrated to positively affect insulin signaling activities potentially through increasing the secretion of insulin sensitizing adipokines and/or decreasing the secretion of pro-inflammatory ...


Human Biomechanics Ii Course Project, Abdelaziz Mohammad 2017 Wright State University

Human Biomechanics Ii Course Project, Abdelaziz Mohammad

Best Integrated Writing

Mohammad tested Human Arm Module PASCO ME-6807A, in order to determine some of the biomechanical characteristics, such as force, tension, instantaneous angular velocity, and acceleration vs. angular position required for various movements and arm positions in space.


Rapid Cell Extraction In Aqueous Two-Phase Microdroplet Systems, Kalpana Vijayakumar, Shelly Gulati, Andrew J. de Mello, Joshua B. Edel 2017 Imperial College London

Rapid Cell Extraction In Aqueous Two-Phase Microdroplet Systems, Kalpana Vijayakumar, Shelly Gulati, Andrew J. De Mello, Joshua B. Edel

Shelly Gulati

Distinguishing specific cells is an essential technique in cell research and clinical diagnostics. We report a novel method to passively isolate and extract cells in a microfluidic device. We utilise a droplet-based microfluidic system to generate an aqueous two phase system in which aqueous droplets consist of two phases in the form of a double emulsion. Specifically, we generate PEG droplets that completely encapsulate DEX droplets within a microfluidic channel. Target cells can be introduced directly into the droplets and driven to partition to the more favourable phase, whilst still being contained within the aqueous droplet. Human T lymphoma cells ...


A Deterministic Model Of The Effect Of Electric Field On Chemotherapeutics Delivery Into A Tumor, Maryam Moarefian, Luke Achenie 2017 Virginia Polytechnic Institute and State University

A Deterministic Model Of The Effect Of Electric Field On Chemotherapeutics Delivery Into A Tumor, Maryam Moarefian, Luke Achenie

Biology and Medicine Through Mathematics Conference

No abstract provided.


Optimizing Microfluidic Design For Cell Separation, Joseph Wakim, Marisel De Jesus Vega, Nese Orbey, Carol Barry 2017 University of Massachusetts Lowell

Optimizing Microfluidic Design For Cell Separation, Joseph Wakim, Marisel De Jesus Vega, Nese Orbey, Carol Barry

UMass Center for Clinical and Translational Science Research Retreat

To evaluate the performance of various designs of crossflow filtration microfluidic devices, blood flow was modeled using computational fluid dynamics software (COMSOL Multiphysics). Velocity profiles were generated and used to analyze four critical design parameters: pillar size, pillar shape, gap size, and wall length. These parameters were optimized to yield greatest flow from an unfiltered main channel into two filtered side channels of the device, thereby maximizing filtration capacity.

Devices containing pillars of 10 µm diameter yielded a significantly greater filtration capacity than devices with pillars of 20 µm diameter. Flow patterns from the main channel to the side channels ...


Dynamic Simulation And Analysis Of Gait Modification For Treating Knee Osteoarthritis, Taylor Elyse Schlotman 2017 University of Tennessee, Knoxville

Dynamic Simulation And Analysis Of Gait Modification For Treating Knee Osteoarthritis, Taylor Elyse Schlotman

Doctoral Dissertations

Roughly 47.5 million people in the US have a disability, with 8.6 million reporting arthritis as their main cause of disability, making arthritis the leading cause of physical disability. With decreased mortality rates and a large, aging baby boomer generation, there will be more adults living with chronic musculoskeletal conditions causing disabilities that limit walking. Since walking ability is directly related to an individual’s independence at home and in the community, losing this ability is a major setback for patients with arthritis. Knee osteoarthritis (OA) is the most prevalent form of arthritis affecting approximately 27 million adults ...


Musculoskeletal Loads During Stationary Cycling And The Effects Of Pedal Modifications For Knee Osteoarthritis, Rachel Lynn Thompson 2017 University of Tennessee, Knoxville

Musculoskeletal Loads During Stationary Cycling And The Effects Of Pedal Modifications For Knee Osteoarthritis, Rachel Lynn Thompson

Doctoral Dissertations

Knee OA is a deteriorating joint disease affecting 27 million people in the US and current exercise prescriptions may be improved with new knowledge of their effects on muscle forces and joint contact loads. Cycling rather than other exercise modalities is generally considered an alternative for people with knee OA. If these research objectives were achieved, clinicians would have additional tools related to joint contact loads for treating people with OA with an cycling exercise while controlling progression of OA. The long-term goal of this research is to provide a scientific basis for planning, evaluation and improvement of subject-specific rehabilitation ...


Chemical And Physical Priming Of Human Mesenchymal Stem Cells To Alter Nonviral Gene Delivery Outcomes, Tyler Kozisek, Andrew Hamann, Amy Mantz, Mathias Schubert, Eva Schubert, Angela K. Pannier 2017 University of Nebraska-Lincoln

Chemical And Physical Priming Of Human Mesenchymal Stem Cells To Alter Nonviral Gene Delivery Outcomes, Tyler Kozisek, Andrew Hamann, Amy Mantz, Mathias Schubert, Eva Schubert, Angela K. Pannier

Biological Systems Engineering--Dissertations, Theses, and Student Research

Human Mesenchymal Stem Cells: Human mesenchymal stem cells (hMSCs) are a multipotent cell, meaning they are able to differentiate into a more mature cell type, such as osteocytes, chondrocytes, and adipocytes, that are found in numerous tissues in the human body, such as bone marrow, fat, and muscle. Since hMSCs can be derived from adult human tissues, they do not have the same ethical concern associated with them as other stem cells, such as embryonic stem cells. Due to hMSCs multipotency and ease of obtaining, they have become one of the most widely researched stem cell types in areas such ...


Assessment Of The Non-Linear Stress-Strain Characteristics Of Poly (Vinyl Alcohol) Cryogel, Mojdeh Zakeri 2017 The University of Western Ontario

Assessment Of The Non-Linear Stress-Strain Characteristics Of Poly (Vinyl Alcohol) Cryogel, Mojdeh Zakeri

Electronic Thesis and Dissertation Repository

Creation of tissue-mimicking constructs is of great importance in the field of biomedical engineering. Poly (vinyl Alcohol) (PVA) is a biomaterial capable of simulating a wide range of geometries and mechanical properties of biological tissues. It is nontoxic, biocompatible, and easy to produce. PVA can be physically crosslinked by repeated cycles of freezing and thawing. The final product of this process is called PVA cryogel (PVA-C). The mechanical properties of PVA-C can be accurately controlled by changing PVA molecular weight, PVA concentration, and number and duration of freeze/thaw cycles (FTC). In this study, the stress-strain behavior of PVA cryogel ...


Validation Of Postural Sway Measurements Using Wii Balance Board, Zachary Meade 2017 University of Nebraska Omaha

Validation Of Postural Sway Measurements Using Wii Balance Board, Zachary Meade

Student Research and Creative Activity Fair

Standing balance measurements, such as postural sway, are vital for determining functional ability, risk of falling and recovery of injuries. Often the need to collect data outside of the typical clinical or research setting arises. However, obtaining these measurements outside of a laboratory setting can be very difficult, as the mobility of a laboratory-grade force plate (FP) is minimal, and its cost can be upwards of $20,000. The purpose of this study is to create a cheaper alternative by validating the Wii Balance Board’s (WBB; Nintendo, Redmond, Washington, USA) ability to measure postural sway patterns. The WBB can ...


Peak Vertical Ground Reaction Force & Stance Phase Time To Assess Post-Tka Interlimb Asymmetry, Abderrahman Ouattas 2017 University of Nebraska at Omaha

Peak Vertical Ground Reaction Force & Stance Phase Time To Assess Post-Tka Interlimb Asymmetry, Abderrahman Ouattas

Student Research and Creative Activity Fair

In the US, more than 500,000 TKA surgeries are performed annually, to which 97% of those are led by OA1. Although knee pain is diminished post-TKA, unilateral efficiency and walking asymmetry is still unresolved several years after the surgery2. In fact, within a minimum of 10 years after the primary TKA, almost 50% of patients undergo a secondary TKA on the contralateral limb due to OA progression3. The purpose of this study was to determine if post-Total Knee Arthroplasty peak vertical ground reaction force (pVGRF) asymmetry could be identified using stance phase time differences between the ...


Acl Reconstruction Results In Alterations For Force Control Variability During Multidirectional Force Production, Amelia S. Lanier 2017 University of Nebraska at Omaha

Acl Reconstruction Results In Alterations For Force Control Variability During Multidirectional Force Production, Amelia S. Lanier

Student Research and Creative Activity Fair

After anterior cruciate ligament (ACL) rupture most will undergo reconstructive surgery. Within the first year after surgery 25% of patients will re-tear their ACL. Most of those injured attempt to return to sports which include running and cutting. The ability to produce appropriate ground reaction forces may be crucial for the successful return to sports without re-injury. Understanding stability of multidirectional ground reaction force (mGRF) production in healthy and ACL reconstructed (ACL-r) patients can lend insight to the high instance of re-injury. Typically, stability has been measured using linear analyses, but these analyses cannot capture the subtle time varying changes ...


The Effects Of Walking Speed On Gait Propulsion When Wearing An Ankle-Foot Orthosis, Alli Kalina 2017 University of Nebraska at Omaha

The Effects Of Walking Speed On Gait Propulsion When Wearing An Ankle-Foot Orthosis, Alli Kalina

Student Research and Creative Activity Fair

Peripheral artery disease (PAD) is a cardiovascular disease that results from blockage of one or more arteries in the lower extremity. Often, patients with PAD have reduced ability to push off with the foot at the end of the gait cycle. When walking, the ankle contributes the majority of the power to propel the body into the next step. An ankle-foot orthosis (AFO) is a device that aids in ankle propulsion by increasing the energy return, thus decreasing the ankle deficit in pathological individuals. The purpose is to investigate the effect of walking speed on ankle propulsion during walking. Subjects ...


Estimation Of The Centre Of Mass From Motion Capture And Force Plate Recordings: A Study On The Elderly, Sebastien Cotton, Michele Vanoncini, Philippe Fraisse, Nacim Ramdani, Emel Demircan, Andrew P. Murray, Thierry Keller 2017 Universite de Montpellier II

Estimation Of The Centre Of Mass From Motion Capture And Force Plate Recordings: A Study On The Elderly, Sebastien Cotton, Michele Vanoncini, Philippe Fraisse, Nacim Ramdani, Emel Demircan, Andrew P. Murray, Thierry Keller

Andrew P. Murray

The estimation of the centre of mass position in humans is usually based on biomechanical models developed from anthropometric tables. This method can potentially introduce errors in studies involving elderly people, since the ageing process is typically associated with a modification of the distribution of the body mass. In this paper, an alternative technique is proposed, and evaluated with an experimental study on 9 elderly volunteers. The technique is based on a virtual chain, identified from experimental data and locating the subject's centre of mass. Its configuration defines the location of the centre of mass, and is a function ...


Shape Recovery With Concomitant Mechanical Strengthening Of Amphiphilic Shape Memory Polymers In Warm Water, Ben Zhang, Janae E. DeBartolo, Jie Song 2017 University of Massachusetts Medical School

Shape Recovery With Concomitant Mechanical Strengthening Of Amphiphilic Shape Memory Polymers In Warm Water, Ben Zhang, Janae E. Debartolo, Jie Song

University of Massachusetts Medical School Faculty Publications

Maintaining adequate or enhancing mechanical properties of shape memory polymers (SMPs) after shape recovery in an aqueous environment are greatly desired for biomedical applications of SMPs as self-fitting tissue scaffolds or minimally invasive surgical implants. Here we report stable temporary shape fixing and facile shape recovery of biodegradable triblock amphiphilic SMPs containing a poly(ethylene glycol) (PEG) center block and flanking poly(lactic acid) or poly(lactic-co-glycolic acid) blocks in warm water, accompanied by concomitant enhanced mechanical strengths. Differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WXRD), and small-angle X-ray scattering (SAXS) analyses revealed that the unique stiffening of the amphiphilic ...


Design Of A Device For Measuring Bulk Fluid Flow In Spine Segments Under Tensile Loads, Tysum Ruchti, Anton Bowden 2017 Brigham Young University

Design Of A Device For Measuring Bulk Fluid Flow In Spine Segments Under Tensile Loads, Tysum Ruchti, Anton Bowden

Biomedical Engineering Western Regional Conference

No abstract provided.


Effect Of Multiple Confined Compression/Stress Relaxation Cycles On Cross-Linked Alginate Pore Size., Sindhu Kolar Venkat, Erik L. Risa, Bergren Antell, Maryam Mobed-Miremadi 2017 Santa Clara University

Effect Of Multiple Confined Compression/Stress Relaxation Cycles On Cross-Linked Alginate Pore Size., Sindhu Kolar Venkat, Erik L. Risa, Bergren Antell, Maryam Mobed-Miremadi

Biomedical Engineering Western Regional Conference

No abstract provided.


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