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Biomechanics and Biotransport Commons

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A Deterministic Model Of The Effect Of Electric Field On Chemotherapeutics Delivery Into A Tumor, Maryam Moarefian, Luke Achenie 2017 Virginia Polytechnic Institute and State University

A Deterministic Model Of The Effect Of Electric Field On Chemotherapeutics Delivery Into A Tumor, Maryam Moarefian, Luke Achenie

Biology and Medicine Through Mathematics Conference

No abstract provided.


Validation Of Postural Sway Measurements Using Wii Balance Board, Zachary Meade 2017 University of Nebraska Omaha

Validation Of Postural Sway Measurements Using Wii Balance Board, Zachary Meade

Student Research and Creative Activity Fair

Standing balance measurements, such as postural sway, are vital for determining functional ability, risk of falling and recovery of injuries. Often the need to collect data outside of the typical clinical or research setting arises. However, obtaining these measurements outside of a laboratory setting can be very difficult, as the mobility of a laboratory-grade force plate (FP) is minimal, and its cost can be upwards of $20,000. The purpose of this study is to create a cheaper alternative by validating the Wii Balance Board’s (WBB; Nintendo, Redmond, Washington, USA) ability to measure postural sway patterns. The WBB can ...


Peak Vertical Ground Reaction Force & Stance Phase Time To Assess Post-Tka Interlimb Asymmetry, Abderrahman Ouattas 2017 University of Nebraska at Omaha

Peak Vertical Ground Reaction Force & Stance Phase Time To Assess Post-Tka Interlimb Asymmetry, Abderrahman Ouattas

Student Research and Creative Activity Fair

In the US, more than 500,000 TKA surgeries are performed annually, to which 97% of those are led by OA1. Although knee pain is diminished post-TKA, unilateral efficiency and walking asymmetry is still unresolved several years after the surgery2. In fact, within a minimum of 10 years after the primary TKA, almost 50% of patients undergo a secondary TKA on the contralateral limb due to OA progression3. The purpose of this study was to determine if post-Total Knee Arthroplasty peak vertical ground reaction force (pVGRF) asymmetry could be identified using stance phase time differences between the ...


Acl Reconstruction Results In Alterations For Force Control Variability During Multidirectional Force Production, Amelia S. Lanier 2017 University of Nebraska at Omaha

Acl Reconstruction Results In Alterations For Force Control Variability During Multidirectional Force Production, Amelia S. Lanier

Student Research and Creative Activity Fair

After anterior cruciate ligament (ACL) rupture most will undergo reconstructive surgery. Within the first year after surgery 25% of patients will re-tear their ACL. Most of those injured attempt to return to sports which include running and cutting. The ability to produce appropriate ground reaction forces may be crucial for the successful return to sports without re-injury. Understanding stability of multidirectional ground reaction force (mGRF) production in healthy and ACL reconstructed (ACL-r) patients can lend insight to the high instance of re-injury. Typically, stability has been measured using linear analyses, but these analyses cannot capture the subtle time varying changes ...


The Effects Of Walking Speed On Gait Propulsion When Wearing An Ankle-Foot Orthosis, Alli Kalina 2017 University of Nebraska at Omaha

The Effects Of Walking Speed On Gait Propulsion When Wearing An Ankle-Foot Orthosis, Alli Kalina

Student Research and Creative Activity Fair

Peripheral artery disease (PAD) is a cardiovascular disease that results from blockage of one or more arteries in the lower extremity. Often, patients with PAD have reduced ability to push off with the foot at the end of the gait cycle. When walking, the ankle contributes the majority of the power to propel the body into the next step. An ankle-foot orthosis (AFO) is a device that aids in ankle propulsion by increasing the energy return, thus decreasing the ankle deficit in pathological individuals. The purpose is to investigate the effect of walking speed on ankle propulsion during walking. Subjects ...


Estimation Of The Centre Of Mass From Motion Capture And Force Plate Recordings: A Study On The Elderly, Sebastien Cotton, Michele Vanoncini, Philippe Fraisse, Nacim Ramdani, Emel Demircan, Andrew P. Murray, Thierry Keller 2017 Universite de Montpellier II

Estimation Of The Centre Of Mass From Motion Capture And Force Plate Recordings: A Study On The Elderly, Sebastien Cotton, Michele Vanoncini, Philippe Fraisse, Nacim Ramdani, Emel Demircan, Andrew P. Murray, Thierry Keller

Andrew P. Murray

The estimation of the centre of mass position in humans is usually based on biomechanical models developed from anthropometric tables. This method can potentially introduce errors in studies involving elderly people, since the ageing process is typically associated with a modification of the distribution of the body mass. In this paper, an alternative technique is proposed, and evaluated with an experimental study on 9 elderly volunteers. The technique is based on a virtual chain, identified from experimental data and locating the subject's centre of mass. Its configuration defines the location of the centre of mass, and is a function ...


Design Of A Device For Measuring Bulk Fluid Flow In Spine Segments Under Tensile Loads, Tysum Ruchti, Anton Bowden 2017 Brigham Young University

Design Of A Device For Measuring Bulk Fluid Flow In Spine Segments Under Tensile Loads, Tysum Ruchti, Anton Bowden

Biomedical Engineering Western Regional Conference

No abstract provided.


Effect Of Multiple Confined Compression/Stress Relaxation Cycles On Cross-Linked Alginate Pore Size., Sindhu Kolar Venkat, Erik L. Risa, Bergren Antell, Maryam Mobed-Miremadi 2017 Santa Clara University

Effect Of Multiple Confined Compression/Stress Relaxation Cycles On Cross-Linked Alginate Pore Size., Sindhu Kolar Venkat, Erik L. Risa, Bergren Antell, Maryam Mobed-Miremadi

Biomedical Engineering Western Regional Conference

No abstract provided.


Modeling The Combined Effect Of Convection And Diffusion In Cross-Linked Alginate Capsules, Erik L. Risa, Sindhu Kolar Venkat, Bergren Antell, Maryam Mobed-Miremadi 2017 Santa Clara University

Modeling The Combined Effect Of Convection And Diffusion In Cross-Linked Alginate Capsules, Erik L. Risa, Sindhu Kolar Venkat, Bergren Antell, Maryam Mobed-Miremadi

Biomedical Engineering Western Regional Conference

No abstract provided.


Rapid And Label-Free Detection Of Interferon Gamma Via An Electrochemical Aptasensor Comprising A Ternary Surface Monolayer On A Gold Interdigitated Electrode Array, Shaowei Ding, Curtis L. Mosher, Xian Y. Lee, Suprem R. Das, Allison A. Cargill, Xiaohui Tang, Bolin Chen, Eric S. McLamore, Carmen Gomes, Jesse M. Hostetter, Jonathan C. Claussen 2017 Iowa State University

Rapid And Label-Free Detection Of Interferon Gamma Via An Electrochemical Aptasensor Comprising A Ternary Surface Monolayer On A Gold Interdigitated Electrode Array, Shaowei Ding, Curtis L. Mosher, Xian Y. Lee, Suprem R. Das, Allison A. Cargill, Xiaohui Tang, Bolin Chen, Eric S. Mclamore, Carmen Gomes, Jesse M. Hostetter, Jonathan C. Claussen

Mechanical Engineering Publications

A label-free electrochemical impedance spectroscopy (EIS) aptasensor for rapid detection (<35 min) of interferon-gamma (IFN-γ) was fabricated by immobilizing a RNA aptamer capture probe (ACP), selective to IFN-γ, on a gold interdigitated electrode array (Au IDE). The ACP was modified with a thiol group at the 5′ terminal end and subsequently co-immobilized with 1,6-hexanedithiol (HDT) and 6-mercapto-1-hexanolphosphate (MCH) to the gold surface through thiol–gold interactions. This ACP/HDT-MCH ternary surface monolayer facilitates efficient hybridization with IFN-γ and displays high resistance to nonspecific adsorption of nontarget proteins [i.e., fetal bovine serum (FBS) and bovine serum albumin (BSA)]. The Au IDE functionalized with ACP/HDT-MCH was able to measure IFN-γ in actual FBS solution with a linear sensing range from 22.22 pM to 0.11 nM (1–5 ng/mL) and a detection limit of 11.56 pM. The ability to rapidly sense IFN-γ within this sensing range makes the developed electrochemical platform conducive toward in-field disease detection of a variety of diseases including paratuberculosis (i.e., Johne’s Disease). Furthermore, experimental results were numerically validated with an equivalent circuit model that elucidated the effects of the sensing process and the influence of the immobilized ternary monolayer on signal output. This is the first time that ternary surface monolayers have been used to selectively capture/detect IFN-γ on Au IDEs.


Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff 2016 University of Nebraska - Lincoln

Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff

Computer Science and Engineering: Theses, Dissertations, and Student Research

Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit them for novel purposes, such as the development of ubiquitous and heterogeneous communication networks to interconnect biological cells with nano and biotechnology-enabled devices, i.e., the Internet of Bio-Nano Things. One major problem in realizing these goals stands in the development of reliable techniques to control the engineered cells and their behavior from ...


Synchronization And Random Triggering Of Lymphatic Vessel Contractions, James W. Baish, Christian Kunert, Timothy P. Padera, Lance L. Munn 2016 Bucknell University

Synchronization And Random Triggering Of Lymphatic Vessel Contractions, James W. Baish, Christian Kunert, Timothy P. Padera, Lance L. Munn

Faculty Journal Articles

The lymphatic system is responsible for transporting interstitial fluid back to the bloodstream, but unlike the cardiovascular system, lacks a centralized pump-the heart–to drive flow. Instead, each collecting lymphatic vessel can individually contract and dilate producing unidirectional flow enforced by intraluminal check valves. Due to the large number and spatial distribution of such pumps, high-level coordination would be unwieldy. This leads to the question of how each segment of lymphatic vessel responds to local signals that can contribute to the coordination of pumping on a network basis. Beginning with elementary fluid mechanics and known cellular behaviors, we show that ...


Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson 2016 University of Tennessee - Knoxville

Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson

Michael Johnson

Osteoarthritis (OA) of the knee is one of the leading causes of chronic disability (along with the hip). Due to rising healthcare costs associated with OA, it is important to fully understand the disease and how it progresses in the knee. One symptom of knee OA is the degeneration of cartilage in the articulating knee. The cartilage pad plays a major role in painting the biomechanical picture of the knee. This work attempts to quantify the cartilage thickness of healthy male and female knees using statistical shape models (SSMs) for a deep knee bend activity. Additionally, novel cartilage segmentation from ...


Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson 2016 University of Tennessee - Knoxville

Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson

Michael Johnson

Osteoarthritis (OA) of the knee is one of the leading causes of chronic disability (along with the hip). Due to rising healthcare costs associated with OA, it is important to fully understand the disease and how it progresses in the knee. One symptom of knee OA is the degeneration of cartilage in the articulating knee. The cartilage pad plays a major role in painting the biomechanical picture of the knee. This work attempts to quantify the cartilage thickness of healthy male and female knees using statistical shape models (SSMs) for a deep knee bend activity. Additionally, novel cartilage segmentation from ...


Industrial Solid-State Energy Harvesting: Mechanisms And Examples, Matthew Kocoloski, Carl Eger, Robin McCarty, Kevin P. Hallinan, J. Kelly Kissock 2016 Carnegie Mellon University

Industrial Solid-State Energy Harvesting: Mechanisms And Examples, Matthew Kocoloski, Carl Eger, Robin Mccarty, Kevin P. Hallinan, J. Kelly Kissock

J. Kissock

This paper explores the potential for solid-state energy harvesting in industrial applications. In contrast to traditional heat recovery, the output of solid-state devices is electricity, which can be readily used in virtually any plant. The progress in harvesting waste heat via thermoelectric and thermionic generators is described. With second law efficiencies now approaching 50% and 80% respectively, we show that these technologies are on the cusp of practical use. Finally, we present an example of energy harvesting using thermionic devices in an industrial application. The example considers energy harvesting from a furnace at a glass manufacturing facility where exhaust gases ...


Development Of Standard Criteria To Evaluate The Effectiveness Of Helmets At Decreasing The Risk Of Concussions, Daniel Y. Shyu, Goutham N. Sankaran, Kevin G. McIver, Nicolas Leiva, Eric A. Nauman 2016 Purdue University

Development Of Standard Criteria To Evaluate The Effectiveness Of Helmets At Decreasing The Risk Of Concussions, Daniel Y. Shyu, Goutham N. Sankaran, Kevin G. Mciver, Nicolas Leiva, Eric A. Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

In many sports, such as American football, accumulations of mild traumatic brain injuries have been suggested as a possible link to neurodegeneration and future mental disorders. With head impacts occurring at all levels of competition and in different sports, it is critical to develop an accurate method for quantifying the effects of head impacts and determining the efficacy of helmets. This study examines the derivation of different dimensionless numbers and ascertains the critical factors needed to predict the effects of head impacts, specifically the resulting accelerations from an impact. Given a known force of impact, parameters such as peak translation ...


Ball Pressure Correlations With Peak Impact Force And The Potential For Cumulative Mtbi When Heading A Soccer Ball, Nicolas Leiva, Daniel Y. Shyu, Josh Auger, Eric Nauman 2016 Universidad de Los Andes - Colombia

Ball Pressure Correlations With Peak Impact Force And The Potential For Cumulative Mtbi When Heading A Soccer Ball, Nicolas Leiva, Daniel Y. Shyu, Josh Auger, Eric Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

Soccer is a unique sport in which athletes use their heads as tools for gameplay, which may ultimately cause cumulative traumatic brain injuries. Due to rising popularity of soccer in the United States alongside the increased occurrence of CTE and mTBI in other contact sports, there is a growing concern over how to keep the repetitive forces caused by heading, as low as possible. Different variables that can affect the peak force felt when heading a soccer ball can be simulated and compared with in-game data, however, this has never been properly tested before. In the present study two size ...


Microscale Investigation Of Thermo-Fluid Transport In The Transition Fil, Region Of An Evaporating Capillary Meniscus Using A Microgravity Environment, Kenneth D. Kihm, Jeffrey S. Allen, Kevin P. Hallinan, David M. Pratt 2016 University of Tennessee, Knoxville

Microscale Investigation Of Thermo-Fluid Transport In The Transition Fil, Region Of An Evaporating Capillary Meniscus Using A Microgravity Environment, Kenneth D. Kihm, Jeffrey S. Allen, Kevin P. Hallinan, David M. Pratt

Kevin Hallinan

In order to enhance the fundamental understanding of thin film evaporation and thereby improve the critical design concept for two-phase heat transfer devices, microscale heat and mass transport is to be investigated for the transition film region using state-of-the-art optical diagnostic techniques. By utilizing a microgravity environment, the length scales of the transition film region can be extended sufficiently, from submicron to micron, to probe and measure the microscale transport fields which are affected by intermolecular forces. Extension of the thin film dimensions under microgravity will be achieved by using a conical evaporator made of a thin silicon substrate under ...


Nanocharacterization Of Bio-Silica Using Atomic Force And Ultrasonic Force Microscopy, Vinaypreet S. Gill, Kevin P. Hallinan, N. S. Brar 2016 Brown University

Nanocharacterization Of Bio-Silica Using Atomic Force And Ultrasonic Force Microscopy, Vinaypreet S. Gill, Kevin P. Hallinan, N. S. Brar

Kevin Hallinan

Nanotechnology has become central to our research efforts to fabricate relatively smaller size devices, which are more versatile than their older and larger predecessors. Silica is a very important material in this regard. Recently, a new biomimetically inspired path to silica production has been demonstrated. This processing technique was inspired from biological organisms, such as marine diatoms, which produce silica at ambient conditions and almost neutral ph with beautiful control over location and structure. Recently, several researchers have demonstrated that positional control of silica formed could be achieved by application of an electric field to locate charged enzymes responsible for ...


Leveraging Students’ Passion And Creativity: Ethos At The University Of Dayton, Margaret Pinnell, Malcolm Daniels, Kevin P. Hallinan, Gretchen Berkemeier 2016 University of Dayton

Leveraging Students’ Passion And Creativity: Ethos At The University Of Dayton, Margaret Pinnell, Malcolm Daniels, Kevin P. Hallinan, Gretchen Berkemeier

Kevin Hallinan

The Engineers in Technical Humanitarian Opportunities of Service-learning (ETHOS) program was developed in the spring of 2001 by an interdisciplinary group (electrical, chemical, civil and mechanical) of undergraduate engineering students at the University of Dayton (UD). ETHOS was founded on the belief that engineers are more apt and capable to appropriately serve our world if they have an understanding of technology’s global linkage with values, culture, society, politics, and the economy. Since 2001, the ETHOS program at UD has grown and changed.

From conceptualization, to implementation, to maturation and national recognition, the program has addressed challenges of academic acceptance ...


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