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Biomechanics and Biotransport Commons

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Optimal Design Of Bacterial Carpets For Fluid Pumping, Minghao W. Rostami, Weifan Liu, Amy Buchmann, Eva Strawbridge, Longhua Zhao 2022 Syracuse University

Optimal Design Of Bacterial Carpets For Fluid Pumping, Minghao W. Rostami, Weifan Liu, Amy Buchmann, Eva Strawbridge, Longhua Zhao

Biology and Medicine Through Mathematics Conference

No abstract provided.


Insole Fall Prevention Device, Nick M. Hughes, Andrew M. Slaboda 2022 California Polytechnic State University, San Luis Obispo

Insole Fall Prevention Device, Nick M. Hughes, Andrew M. Slaboda

Biomedical Engineering

Falls among the aging population occur every single day, with 1 in every 5 resulting in some injury and 300,000 hospitalized every year with a hip fracture [1]. The most popular and effective way to mitigate these falls is through physical therapist intervention. However, with the increased popularity in telerehab, many patients at risk for falls cannot accurately convey their gait tendencies to their physical therapists from the comfort of their home or while not in direct contact with the PT. A device like an insole, implanted with force sensors, which measures different parts of a patient’s foot ...


Design Of A Four Channel Pulsatile Perfusion Bioreactor For Ex-Vivo Study Of Vascular Grafts, Thomas M. Fair 2022 Clemson University

Design Of A Four Channel Pulsatile Perfusion Bioreactor For Ex-Vivo Study Of Vascular Grafts, Thomas M. Fair

All Theses

Cardiovascular diseases are the leading cause of death in the United States. Atherosclerosis in peripheral arteries is a major contributing factor. Autologous saphenous vein grafts are the most common bypass grafts for treating peripheral artery diseases. A quarter of these grafts fail within a year, and around half have failed within 10 years of the initial surgery. Graft failure is attributed to the development of intimal hyperplasia indicated by the migration and proliferation of vascular smooth muscle cells, fibroblasts, and the deposition of extracellular proteins.

Increases in flow, pressure, the pulse frequency, and the differential of pressure that model an ...


The Application Of Digital Volume Correlation Bone Strain Measurements In The Osteoarthritic Glenohumeral Joint, Jakub R. Targosinski 2022 The University of Western Ontario

The Application Of Digital Volume Correlation Bone Strain Measurements In The Osteoarthritic Glenohumeral Joint, Jakub R. Targosinski

Electronic Thesis and Dissertation Repository

This thesis investigates the accuracy and precision of digital volume correlation measurements derived from micro-computed tomography imagery of interfaces in the upper extremity of clinical relevance, namely, the implant-cement-bone interface of glenoid implants used in total shoulder arthroplasties and the implant-bone interface of shoulder hemiarthroplasties. The works within derive relationships between measurement accuracy and precision and parameters of practical interest such as image quality and measurement spatial resolution. It also analyzes the effects of micro-computed tomography image artifact-inducing materials on the accuracy and precision of digital volume correlation-based measurements and the spatial relationship between distance between the artifacting material and ...


A Novel Ultrasound Elastography Technique For Evaluating Tumor Response To Neoadjuvant Chemotherapy In Patients With Locally Advanced Breast Cancer, Niusha Kheirkhah 2022 The University of Western Ontario

A Novel Ultrasound Elastography Technique For Evaluating Tumor Response To Neoadjuvant Chemotherapy In Patients With Locally Advanced Breast Cancer, Niusha Kheirkhah

Electronic Thesis and Dissertation Repository

Breast cancer is the second most diagnosed cancer in women, estimated to affect 1 in 8 women during their lifetime. About 10% to 20% of new breast cancer cases are diagnosed with locally advanced breast cancer (LABC). LABC tumors are usually larger than 5 cm and/or attached to the skin or chest wall. It has been reported that when such cases are treated with surgery alone, metastasis and mortality rates are high, especially where skin involvement or attachment to the chest wall is extensive. As such, efficient treatment for this kind of breast cancer includes neoadjuvant chemotherapy (NAC) to ...


Tracking Simulated Somatosensory Deficiencies That Affect Postural Stability Through Detrended Fluctuation Analysis, Cameron Steele 2022 Olivet Nazarene University

Tracking Simulated Somatosensory Deficiencies That Affect Postural Stability Through Detrended Fluctuation Analysis, Cameron Steele

Scholar Week 2016 - present

Falls are a prevalent problem within elderly populations. Falls also increase the cost of healthcare, since they cause severe injuries frequently and negatively affect quality of life. Lack of postural stability is the consequence of falls, and postural stability is defined as the correct biomechanical execution based on sensory feedback. The types of sensory feedback are vision, vestibular (ear), proprioceptive (body awareness), and somatosensory (sensation of the environment). This study focuses on the lack of postural stability in quiet standing due to somatosensory and vision deficiencies. To track these deficiencies, 51 subjects stood for 60 seconds on two force plates ...


Biomechanical Analysis Of Athletes Sprinting With Varying Degrees Of Resistance, Michaela Ott 2022 University of Nebraska - Lincoln

Biomechanical Analysis Of Athletes Sprinting With Varying Degrees Of Resistance, Michaela Ott

Honors Theses, University of Nebraska-Lincoln

Utilizing resistance methods for sprinters is a common approach to their training. In this study, six athletes from the University of Nebraska-Lincoln Women’s Track and Field Team ran a series of sprints using a resistance machine to collect data regarding the change in power output, stride length, level of trunk tilt with respect to the ground, and acceleration throughout a distance of ten meters when different amounts of resistant forces were applied to the athlete. It was hypothesized that as resistance increased, power output would increase, stride length would decrease, the runners would become more horizontal resulting in a ...


A Meshless Approach To Computational Pharmacokinetics, Anthony Matthew Khoury 2022 Embry-Riddle Aeronautical University

A Meshless Approach To Computational Pharmacokinetics, Anthony Matthew Khoury

PhD Dissertations and Master's Theses

The meshless method is an incredibly powerful technique for solving a variety of problems with unparalleled accuracy and efficiency. The pharmacokinetic problem of transdermal drug delivery (TDDD) is one such topic and is of significant complexity. The locally collocated meshless method (LCMM) is developed in solution to this topic. First, the meshless method is formulated to model this transport phenomenon and is then validated against an analytical solution of a pharmacokinetic problem set, to demonstrate this accuracy and efficiency. The analytical solution provides a locus by which convergence behavior are evaluated, demonstrating the super convergence of the locally collocated meshless ...


The Effects Of A Porous Internal Lattice Design On The Articular Contact Mechanics Of Radial Head Hemiarthroplasty Implants, Jessica Benitah 2022 The University of Western Ontario

The Effects Of A Porous Internal Lattice Design On The Articular Contact Mechanics Of Radial Head Hemiarthroplasty Implants, Jessica Benitah

Electronic Thesis and Dissertation Repository

Hemiarthroplasty, where one side of a joint is replaced, is a minimally invasive procedure. It allows for the preservation of native tissue, though a significant ramification is accelerated cartilage wear when articulating with high stiffness materials that do not mimic the mechanical stiffness of the native tissue. An implant that employs a lattice design can significantly lower the stiffness of a solid structure whilst maintaining strength. This study was conducted to investigate the effect of implementing a porous internal lattice structure with a thin outer shell on the articular contact mechanics, using a radial head hemiarthroplasty. It was hypothesized that ...


Characterizing Mechanical Regulation Of Bone Metastatic Breast Cancer Cells, Boyuan Liu 2022 University of Massachusetts Amherst

Characterizing Mechanical Regulation Of Bone Metastatic Breast Cancer Cells, Boyuan Liu

Doctoral Dissertations

Breast cancer most frequently metastasizes to the skeleton. Bone metastatic cancer is incurable and induces wide-spread bone osteolysis, resulting in significant patient morbidity and mortality. Mechanical stimuli in the skeleton are an important microenvironmental parameter that modulates tumor formation, osteolysis, and tumor cell-bone cell signaling, but which mechanical signals are the most beneficial and the corresponding molecular mechanisms are unknown. This work focused on bone matrix deformation and interstitial fluid flow based on their well-known roles in bone remodeling and in primary breast cancer. The goal of our research was to establish a platform that could define the relationship between ...


Reducing Loading On The Contralateral Limb Using Human-In-The-Loop Optimization, Siena Senatore 2022 University of Nebraska at Omaha

Reducing Loading On The Contralateral Limb Using Human-In-The-Loop Optimization, Siena Senatore

Student Research and Creative Activity Fair

In most everyday activities, we head towards a specific goal by updating our choices for a more direct path. However, there are specific clinical tasks where taking the direct path is more challenging. Clinical investigations of optimizing a prosthesis involve the assessment of multiple parameter settings through trial and error rather than goal-directed optimization. We investigate if a human-in-the-loop optimization algorithm can guide manual alterations to a prosthesis-simulating device to reduce the ground reaction force on the contralateral limb. In most participants, the optimal condition reduced the loading rate on the contralateral limb compared to the initial condition tested. These ...


Changes In Ankle Muscle Force And Power During Walking In Patients With Peripheral Artery Disease, Hafizur Rahman, Cody Anderson, Iraklis I. Pipinos, Jason M. Johanning, Jianghu Dong, Sara A. Myers 2022 University of Nebraska at Omaha

Changes In Ankle Muscle Force And Power During Walking In Patients With Peripheral Artery Disease, Hafizur Rahman, Cody Anderson, Iraklis I. Pipinos, Jason M. Johanning, Jianghu Dong, Sara A. Myers

Student Research and Creative Activity Fair

Background: Patients with peripheral artery disease (PAD) have significantly reduced lower extremity muscle strength compared with healthy individuals as measured during isolated, single plane joint motion by isometric and isokinetic strength dynamometers. The objective of this study was to understand the contribution of the ankle muscles during walking in patients with PAD and compared to healthy older individuals.

Methods: A total of 12 patients diagnosed with Fontaine stage II PAD and 10 healthy older controls were recruited for the study. Each subject walked across a 10-meter pathway with reflective markers placed on specific anatomical locations on lower limbs while the ...


Bone And Cartilage Compression Simulator, Karoline M. Wucherer, Benjamin A. Parmentier, Thomasina E. Hinkle 2022 California Polytechnic State University, San Luis Obispo

Bone And Cartilage Compression Simulator, Karoline M. Wucherer, Benjamin A. Parmentier, Thomasina E. Hinkle

Biomedical Engineering

A device was developed that delivers mechanical loads to bone and soft tissue samples under physiological conditions to aid in the research of tissue engineering bone and cartilage. To begin the design process, a Network Diagram and Gantt Chart were produced to create a general timeline for the project to follow. This allowed us to measure our progress and determine what effects (if any) delays could have on our project.


Analysis Of Time-Delayed Non-Linear Equations Using Hf Functions, Shailesh Verma, Aniruddha Ghosh, Anindita Ganguly, Nilotpal Chakraborty 2022 Indian Institute of Technology Dhanbad

Analysis Of Time-Delayed Non-Linear Equations Using Hf Functions, Shailesh Verma, Aniruddha Ghosh, Anindita Ganguly, Nilotpal Chakraborty

International Journal of Computer and Communication Technology

The paper deals with the analysis of non-linear time delayed differential equations solved using HF functions. The analysis is first performed on Mackey-Glass Equation, which is a standard model for quantitative characterization of chaotic dynamics. The procedure is then performed on a generalized Human respiratory control model, where for different simulation parameters the analysis of Cheyne-Stokes Breathing is done. Both models are simulated in MATLAB. The graphs thus generated are used to provide suitable conclusions.


Improving Quantification Of Mitral Regurgitation Through Computational Fluid Dynamics And Ex Vivo Testing, Alexandra Flowers 2022 University of Denver

Improving Quantification Of Mitral Regurgitation Through Computational Fluid Dynamics And Ex Vivo Testing, Alexandra Flowers

Electronic Theses and Dissertations

Mitral regurgitation (MR) is a prominent cardiac disease affecting more than two million people in the United States alone. In order for patients to receive proper therapy, regurgitant volume must first be quantified. As there are an array of methods to do so, the proximal isovelocity surface area (PISA) method continues to be the most accurate and clinically used method. However, there are some difficulties obtaining the necessary measurements need for this when performing transthoracic echocardiography. This study aims to evaluate and present techniques that may be used to more accurately quantify regurgitation through ex vivo testing and computational fluid ...


Totally Tubulair - Adjustable Nasal Cannula, Megan Bruns, Emily McGrath, Angelina Marchio, Olivia Renkel 2022 The University of Akron

Totally Tubulair - Adjustable Nasal Cannula, Megan Bruns, Emily Mcgrath, Angelina Marchio, Olivia Renkel

Williams Honors College, Honors Research Projects

Many individuals require short-term and long-term oxygen therapy. These users experience discomfort and problems with the standard nasal cannula that are compounded by issues with oxygen sources being heavy with limited supply and tubing getting tangled, kinked, or not providing enough mobility. The objective of this project was to address ergonomic issues with oxygen therapy devices to increase the ease of use for healthcare workers, patients, and families. By following the engineering design process, a prototype was developed for a nasal cannula with interchangeable prongs. The new design allows users to select a prong size that is more comfortable for ...


Hands Free Fitted Shoe, Maddison Schutt, Nicole Rizkala, Elizabeth Scheatzle, Alexander Hershey, Austin Fowkes 2022 The University of Akron

Hands Free Fitted Shoe, Maddison Schutt, Nicole Rizkala, Elizabeth Scheatzle, Alexander Hershey, Austin Fowkes

Williams Honors College, Honors Research Projects

The ability to don and doff fitted shoes can be a challenge for many people including those diagnosed with diabetes, obesity, limb loss, pregnancy, Parkinson’s disease, arthritis, surgical complications, and aging. Though these actions may seem trivial, the ability to independently put on shoes is necessary because it can significantly impact one’s capacity to complete everyday tasks, hold relationships, and maintain mental health. Current competitors in the market are excessively expensive, not completely hands-free, or not fully enclosed shoes, so a new design for an accessible and affordable hands-free fitted shoe could be of great benefit to the ...


Biomechanical Analysis Of Ligament Modelling Techniques And Femoral Component Malrotation Following Tka, Liam A. Montgomery 2021 The University of Western Ontario

Biomechanical Analysis Of Ligament Modelling Techniques And Femoral Component Malrotation Following Tka, Liam A. Montgomery

Electronic Thesis and Dissertation Repository

Previous studies have demonstrated that satisfaction and revision rates following total knee arthroplasty (TKA) are lower than those of comparable surgeries such as total hip replacements. A leading cause for these revisions is joint instability which may be due to improper ligament balancing or poorly aligned surgical implants. One of the methods used to investigate biomechanical forces and kinematics is computational modelling of the post-operative TKA knee.

A unique knee model was used to investigate the biomechanical and kinematic effects of ligament model complexity, as well as the effects of simulating ligament wrapping versus ignoring ligament wrapping. We then used ...


The Use Of Ct To Assess Shoulder Kinematics And Measure Glenohumeral Arthrokinematics, Baraa Daher 2021 The University of Western Ontario

The Use Of Ct To Assess Shoulder Kinematics And Measure Glenohumeral Arthrokinematics, Baraa Daher

Electronic Thesis and Dissertation Repository

Recently, studies have started employing dynamic four-dimensional computed tomography (4DCT) imaging as a biomechanical assessment tool. These studies would benefit from the valuable work that has been done in the past using three-dimensional computed tomography (3DCT). Thus, a structured review was conducted to examine the extent and range of methods employing CT imaging to measure shoulder kinematics. The findings of the review were utilized to conduct a study that employed 4DCT imaging to measure glenohumeral joint congruency and arthrokinematics during internal rotation to the back in a population of healthy individuals. The results of this work show the importance of ...


Subtalar Joint Definition In Biomechanical Models, Julia Noginova 2021 Old Dominion University

Subtalar Joint Definition In Biomechanical Models, Julia Noginova

Biomedical Engineering Theses & Dissertations

The effect of including a subtalar joint in a dynamic musculoskeletal model has not been fully explored or validated. The subtalar joint is often modeled as a one DOF hinge with the tri-planar axis defined as a combination of inclination and deviation angles measured from the ground and midline of the foot, respectively. The overall purposes of this dissertation were to explore how the inclusion of the subtalar joint and the definition of origin location and axis orientation affect the kinematics, joint kinetics, and muscle activations of the knee, ankle, and subtalar joint during dynamic tasks of walking and running ...


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