Microscale Investigation Of Thermo-Fluid Transport In The Transition Fil, Region Of An Evaporating Capillary Meniscus Using A Microgravity Environment, 2016 University of Tennessee, Knoxville
Microscale Investigation Of Thermo-Fluid Transport In The Transition Fil, Region Of An Evaporating Capillary Meniscus Using A Microgravity Environment, Kenneth D. Kihm, Jeffrey S. Allen, Kevin P. Hallinan, David M. Pratt
In order to enhance the fundamental understanding of thin film evaporation and thereby improve the critical design concept for two-phase heat transfer devices, microscale heat and mass transport is to be investigated for the transition film region using state-of-the-art optical diagnostic techniques. By utilizing a microgravity environment, the length scales of the transition film region can be extended sufficiently, from submicron to micron, to probe and measure the microscale transport fields which are affected by intermolecular forces. Extension of the thin film dimensions under microgravity will be achieved by using a conical evaporator made of a thin silicon substrate under ...
Nanocharacterization Of Bio-Silica Using Atomic Force And Ultrasonic Force Microscopy, 2016 Brown University
Nanocharacterization Of Bio-Silica Using Atomic Force And Ultrasonic Force Microscopy, Vinaypreet S. Gill, Kevin P. Hallinan, N. S. Brar
Nanotechnology has become central to our research efforts to fabricate relatively smaller size devices, which are more versatile than their older and larger predecessors. Silica is a very important material in this regard. Recently, a new biomimetically inspired path to silica production has been demonstrated. This processing technique was inspired from biological organisms, such as marine diatoms, which produce silica at ambient conditions and almost neutral ph with beautiful control over location and structure. Recently, several researchers have demonstrated that positional control of silica formed could be achieved by application of an electric field to locate charged enzymes responsible for ...
Leveraging Students’ Passion And Creativity: Ethos At The University Of Dayton, 2016 University of Dayton
Leveraging Students’ Passion And Creativity: Ethos At The University Of Dayton, Margaret Pinnell, Malcolm Daniels, Kevin P. Hallinan, Gretchen Berkemeier
The Engineers in Technical Humanitarian Opportunities of Service-learning (ETHOS) program was developed in the spring of 2001 by an interdisciplinary group (electrical, chemical, civil and mechanical) of undergraduate engineering students at the University of Dayton (UD). ETHOS was founded on the belief that engineers are more apt and capable to appropriately serve our world if they have an understanding of technology’s global linkage with values, culture, society, politics, and the economy. Since 2001, the ETHOS program at UD has grown and changed.
From conceptualization, to implementation, to maturation and national recognition, the program has addressed challenges of academic acceptance ...
Industrial Solid-State Energy Harvesting: Mechanisms And Examples, 2016 Carnegie Mellon University
Industrial Solid-State Energy Harvesting: Mechanisms And Examples, Matthew Kocoloski, Carl Eger, Robin Mccarty, Kevin P. Hallinan, J. Kelly Kissock
This paper explores the potential for solid-state energy harvesting in industrial applications. In contrast to traditional heat recovery, the output of solid-state devices is electricity, which can be readily used in virtually any plant. The progress in harvesting waste heat via thermoelectric and thermionic generators is described. With second law efficiencies now approaching 50% and 80% respectively, we show that these technologies are on the cusp of practical use. Finally, we present an example of energy harvesting using thermionic devices in an industrial application. The example considers energy harvesting from a furnace at a glass manufacturing facility where exhaust gases ...
Energy Information Augmented Community-Based Energy Reduction, 2016 University of Dayton
Energy Information Augmented Community-Based Energy Reduction, Kevin P. Hallinan, Harvey Enns, Stephenie Ritchey, Phil Brodrick, Nathan Lammers, Nichole Hanus, Mark Rembert, Tony Rainsberger
More than one-half of all U.S. states have instituted energy efficiency mandates requiring utilities to reduce energy use. To achieve these goals, utilities have been permitted rate structures to help them incentivize energy reduction projects. This strategy is proving to be only modestly successful in stemming energy consumption growth. By the same token, community energy reduction programs have achieved moderate to very significant energy reduction. The research described here offers an important tool to strengthen the community energy reduction efforts—by providing such efforts energy information tailored to the energy use patterns of each building occupant. The information provided ...
Clean Energy Infrastructure Educational Initiative, 2016 University of Dayton
Clean Energy Infrastructure Educational Initiative, Kevin P. Hallinan, James A. Menart, Robert Gilbert
The Clean Energy Infrastructure Educational Initiative represents a collaborative effort by the University of Dayton, Wright State University and Sinclair Community College. This effort above all aimed to establish energy related programs at each of the universities while also providing outreach to the local, state-wide, and national communities. At the University of Dayton, the grant has aimed at: solidfying a newly created Master's program in Renewable and Clean Energy; helping to establish and staff a regional sustainability organization for SW Ohio. As well, as the prime grantee, the University of Dayton was responsible for ensuring curricular sharing between WSU ...
A Study Of The Fundamental Operations Of A Capillary Driven Heat Transfer Device In Both Normal And Low Gravity Part 1-Liquid Slug Formation In Low Gravity, Jeffrey S. Allen, Kevin P. Hallinan, Jack Lekan
Research has been conducted to observe the operation of a capillary pumped loop (CPL) in both normal and low gravity environments in order to ascertain the causes of device failure. The failures of capillary pumped heat transport devices in low gravity; specifically; evaporator dryout, are not understood and the available data for analyzing the failures is incomplete.
To observe failure in these devices an idealized experimental CPL was configured for testing in both a normal-gravity and a low-gravity environment. The experimental test loop was constructed completely of Pyrex tubing to allow for visualization of system operations. Heat was added to ...
Prosthetic Leg Kit For Deployment In Developing Countries, 2016 California Polytechnic State University, San Luis Obispo
Prosthetic Leg Kit For Deployment In Developing Countries, Brian Murphy, Dominique Porcincula, Derek Morgan, Kendall Ruggles, Christian Aguayo
Biomedical Eng/General Eng.
The World Health Organization estimates that over 30 million people require some sort of prosthetic technology. However, traditional prosthetic fitting practices take a lot of time and cost a lot of money, making them inaccessible to millions of people around the world. StandUP Worldwide is an interdisciplinary project team devoted to creating low-cost prosthetic technologies for use around the world, especially in resource poor areas. They are currently developing a low cost, below-the-knee prosthetic kit that can be easily deployed in a resource-poor area. The following presents their solution for a below-the-knee prosthetic socket, foot, and leg.
A Reduced Order Model For Efficient Physiological Flow Analysis In Aneurysms By Proper Orthogonal Decomposition, 2016 University of Massachusetts Amherst
A Reduced Order Model For Efficient Physiological Flow Analysis In Aneurysms By Proper Orthogonal Decomposition, Gary Han Chang, Yahya Modarres-Sadeghi
UMass Center for Clinical and Translational Science Research Retreat
Simulating physiological flows using computational fluid dynamics (CFD) remains to be computationally expensive and difficult for clinical usage because of the physiological flow and geometrical complexity involved in patient specific situations. We use the reduced order modeling (ROM) of such systems with high nonlinearity and geometrical non-uniformity to replace the full, nonlinear model with a low-degrees of freedom ROM model. We construct ROM models by the proper orthogonal decomposition (POD) method to estimate the flow-induced wall shear stress (WSS) and pressure loading of a simplified abdominal aortic aneurysm and a bifurcation cerebral aneurysm. This method allows us to investigate a ...
Microengineering Approaches For Regenerative Medicine, 2016 University of Massachusetts Amherst
Microengineering Approaches For Regenerative Medicine, Yubing Sun
UMass Center for Clinical and Translational Science Research Retreat
Stem cells, especially human pluripotent stem cells (hPSCs), hold significant promise for modeling developmental and disease processes, drug and toxicology screening, and cell-based regenerative medicine. Most hPSC studies have so far focused on identifying extrinsic soluble factors, intracellular signaling pathways, and transcriptional regulatory networks involved in regulating hPSC behaviors. We focus on the development and applications of some novel synthetic micromechanical systems to understand the mechano-sensitive and -responsive properties of hPSCs and their functional regulation of self-renewal, directed differentiation, and survival of hPSCs. First, we have demonstrated that rigid PDMS micropost arrays (PMAs) support the maintenance of pluripotency of hPSCs ...
Geometric Control Of Yap-Dependent Mechanotransduction: A Proposed Model, 2016 Worcester Polytechnic Institute
Geometric Control Of Yap-Dependent Mechanotransduction: A Proposed Model, Ngozi A. Eze, Heather A. Cirka, Kristen L. Billiar
UMass Center for Clinical and Translational Science Research Retreat
The Billiar lab is interested in the interplay between mechanical tension and programmed cell death (namely, apoptosis) in cells growing on micro-contact printed aggregates. The Billiar lab uses a bioinspired hydrogel to develop an in vitro model for mechanosensitive signaling in mammalian cells. The micro-contact printed cell aggregates experience a loss of tensional homeostasis at the center of the aggregates, which results in selective cell death at the center, but not periphery of the aggregates, followed by calcification, similar to excised diseased aortic valves. However, the subcellular mechanisms responsible for transducing the mechanical cues from the loss of tensional homeostasis ...
Design Of Exercise Equipment For Wheelchair Users: A Case Study In Accessibility Standards, 2016 University of Connecticut
Design Of Exercise Equipment For Wheelchair Users: A Case Study In Accessibility Standards, Kate Craddock Rescsanszky
Honors Scholar Theses
Engineers must consider a number of aspects of every project they work on. Accessibility is one aspect that presents a unique challenge. Rather than being based on absolute material parameters, accessibility is based on how people interact with technology and their built environment. Since 1990, the Americans with Disabilities Act has been the predominant standard in accessibility because of its wide reach and legal mandate. In addition to the ADA, the ASTM and the Institute for Universal Design offer helpful guidelines for designing for accessibility. However, in addition to standards, guidelines, and recommendations, it is important to consult the intended ...
Wheelchair Fatigue Reducer, 2016 University of Tennessee, Knoxville
Wheelchair Fatigue Reducer, Aaron Miller, Dennis Andre Norfleet
University of Tennessee Honors Thesis Projects
No abstract provided.
Markerless Radiostereogammetry Of The Shoulder Joint In Humans: Comparisons Of Scapulohumeral Kinematics Between Individuals With Healthy And Supraspinatus-Impaired Shoulders, 2016 The University of Western Ontario
Markerless Radiostereogammetry Of The Shoulder Joint In Humans: Comparisons Of Scapulohumeral Kinematics Between Individuals With Healthy And Supraspinatus-Impaired Shoulders, Ashley N. Hannon
Electronic Thesis and Dissertation Repository
The purpose of this collection of studies was to further develop the knowledge of shoulder motion in order to better understand joint function through direct measurement of 3D scapulohumeral joint kinematics using a technique of high accuracy. Markerless, bi-planar fluoroscopic radiostereometric analysis using a generic shoulder model was developed in this thesis, reducing the amount of radiation exposure to subjects. The studies compared kinematic data of the scapulohumeral joint in six degrees of freedom with a precise, in-vivo measuring technique. Data were collected on young and older healthy individuals, individuals with a torn supraspinatus and post-surgical intervention.
Although this generic ...
Reflections Of College Students Promoting Engineering Through Biomechanical Outreach Activities Indicate Dual Benefits, Kimberly Edginton Bigelow
Kimberly Edginton Bigelow
Recent work by the National Academy of Engineering revealed that the public has a poor understanding of what engineers actually do on a day-to-day basis. This issue is compounded for non-traditional fields in engineering, such as biomechanical engineering. This is particularly problematic as such fields could draw interest from students not interested in traditional engineering careers, resulting in increased diversity. To address this, mechanical engineering students taking an elective course, Biomechanical Engineering, were given an outreach assignment to teach at least one individual under the age of 18 about the field of biomechanical engineering through a hands-on activity. Students worked ...
Fluid Flow Characterization In Rapid Prototyped Common Iliac Artery Aneurysm Molds, Daniel Cole Greinke
Master's Theses and Project Reports
The goal of this project was to determine whether i) fused deposition modeling could be employed to manufacture molds for vascular constructs, ii) whether vascular constructs could be created from these molds, and iii) to verify practical equivalence between observed fluid velocities. Dye tracking was to be employed to characterize fluid velocity profiles through the in vitro vascular constructs, including a half-vessel model and a full vessel model of an iliac artery aneurysm. A PDMS half-vessel construct was manufactured, and the movement of dye through the construct was tracked by a cellphone camera. Thresholds were applied to each video in ...
The Rheological Impact Of Cell Activation On The Flow Behavior Of Neutrophils, 2016 University of Kentucky
The Rheological Impact Of Cell Activation On The Flow Behavior Of Neutrophils, Nolan M. Horrall
Theses and Dissertations--Biomedical Engineering
Previously, it was reported that the morphological changes (pseudopod projection) that circulating neutrophils adopt due to cell activation raises peripheral vascular resistance by disrupting microvascular rheology. Studies utilized murine muscle preparations to link neutrophil pseudopod formation to cell activation and a viscous impact on hemodynamic resistance. But because of the complexity associated with the organization of the vasculature and microvasculature in tissues, it was unclear whether the effects of neutrophil activation on hemodynamic resistance were associated with the macro-/micro- circulation. This research describes an in vitro analysis using viscometry and microvascular network mimics (microporous membranes) to assess the rheological ...
Retargeting The Clostridium Botulinum C2 Toxin To The Neuronal Cytosol, 2016 University of Nebraska- Lincoln
Retargeting The Clostridium Botulinum C2 Toxin To The Neuronal Cytosol, Benjamin J. Pavlik, Elizabeth J. Hruska, Kevin Van Cott, Paul Blum
Chemical and Biomolecular Engineering -- All Faculty Papers
Many biological toxins are known to attack specific cell types, delivering their enzymatic payloads to the cytosol. This process can be manipulated by molecular engineering of chimeric toxins. Using toxins with naturally unlinked components as a starting point is advantageous because it allows for the development of payloads separately from the binding/translocation components. Here the Clostridium botulinum C2 binding/translocation domain was retargeted to neural cell populations by deleting its non-specific binding domain and replacing it with a C. botulinum neurotoxin binding domain. This fusion protein was used to deliver fluorescently labeled payloads to Neuro-2a cells. Intracellular delivery was ...
Reference Point Indentation Of Human Trabecular Bone Treated With Bisphosphonates For Varying Durations, 2016 University of Kentucky
Reference Point Indentation Of Human Trabecular Bone Treated With Bisphosphonates For Varying Durations, Drew Jones
Theses and Dissertations--Biomedical Engineering
Reference point indentation (RPI), a novel form of micro-indentation, quantifies RPI material parameters which correlate with modulus, yield stress, strength, or toughness. Information linking bisphosphonate treatment length with the material properties of osteoporotic trabecular bone is needed to improve patient treatment. The objectives of this study were to: 1) determine if RPI can be used to successfully evaluate human trabecular bone and if so, determine an optimized test method for using RPI on trabecular bone, and 2) use this method to determine if any RPI parameters are related to the duration of bisphosphonate treatment.
Indentation using a 4 N applied ...
Protein-Targeted Corona Phase Molecular Recognition, 2016 Massachusetts Institute of Technology
Protein-Targeted Corona Phase Molecular Recognition, Gili Bisker, Juyao Dong, Hoyoung D. Park, Nicole M. Iverson, Jiyoung Ahn, Justin T. Nelson, Markita P. Landry, Sebastian Kruss, Michael S. Strano
Biological Systems Engineering: Papers and Publications
Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening procedure of single-walled carbon nanotubes (SWCNT) and use it against a panel of human blood proteins, revealing a specific corona phase that recognizes fibrinogen with high selectivity. In response to fibrinogen binding, SWCNT fluorescence decreases by >80% at saturation. Sequential binding of the three fibrinogen nodules is suggested by selective fluorescence quenching by isolated sub-domains and validated ...