Biomedical Devices and Instrumentation Commons^™

Air Wear, Ani M. Svadjian, Ada A. Tadeo, Deepthi Ravuru

General Engineering

Since the outbreak of COVID-19 pandemic, hospitals have experienced an overwhelming increase in patients needing respiratory assistance. Our client identified the need for a sustainable, affordable, and portable outpatient device that will provide supplemental oxygen and assisted breathing to speed up the patient recovery process. Our team accomplished to design a device that contains a more sustainable oxygen supply method, has a longer functional duration, is safer and ergonomic, as well as compact.

Eagle Medical Tray Denesting & Debris Removal Process, Nicholas Allen Ungefug, Noah Chavez, Susana Shu-Lin Okhuysen, Michael Augustine Pennington

Industrial and Manufacturing Engineering

Eagle Medical Incorporated is a contract medical device packaging and sterilization company. The company purchases thermoformed medical packaging trays, which maintain the sterility of medical devices, from various manufacturers. To ensure packaging quality and to prevent cleanroom contamination, Eagle Medical inspects and sterilizes each blister tray that they order. This process is an essential non-value-added activity that creates a bottleneck. Cleanroom employees must stop packaging medical devices and attend to the processing of blister trays and packaging solutions. The blister trays arrive at Eagle’s facility in nested stacks. Vibration and movement during shipping further compresses the stacks, which makes ...

Increasing Accessibility To Monitoring Ammonia Levels In The Body Through Development Of A Novel Point-Of-Care Breath Ammonia Diagnostic Device, Emily C. Wright, Ashwin M. Sivalingam

Honors Theses

Hyperammonemia is a life-threatening metabolic condition that is characterized by elevated levels of ammonia concentrations in the blood. Resulting from serious conditions such as chronic kidney disease or liver failure, the limited functions of the liver and kidney lead to an increase in blood urea nitrogen (BUN) within the body. Currently, there are a wide variety of treatments for this condition, ranging from various medications to surgical procedures such as liver transplants. However, there is a lack of variety in diagnostic testing methods to determine a patient’s ammonia levels. In most cases, patients will need to schedule a doctor ...

Hinged Temperature-Immune Self-Referencing Fabry–Pérot Cavity Sensors [Us Patent Us11320596b2], Jeremiah C. Williams, Hengky Chandrahalim

Faculty Publications

A passive microscopic Fabry-Pérot Interferometer (FPI) sensor includes a three-dimensional microscopic optical structure formed on a cleaved tip of the optical fighter using a two-photon polymerization process on a photosensitive polymer by a three-dimensional micromachining device. The three-dimensional microscopic optical structure having a hinged optical layer pivotally connected to a distal portion of a suspended structure. A reflective layer is deposited on a mirror surface of the hinged optical layer while in an open position. The hinged optical layer is subsequently positioned in the closed position to align the mirror surface to at least partially reflect a light signal back ...

Clinical Retractable Infant Barrier, Josh Duzan, Kalani Carter, Jack Oberman, Hunter Thomas

Chancellor’s Honors Program Projects

No abstract provided.

Insole Fall Prevention Device, Nick M. Hughes, Andrew M. Slaboda

Biomedical Engineering

Falls among the aging population occur every single day, with 1 in every 5 resulting in some injury and 300,000 hospitalized every year with a hip fracture [1]. The most popular and effective way to mitigate these falls is through physical therapist intervention. However, with the increased popularity in telerehab, many patients at risk for falls cannot accurately convey their gait tendencies to their physical therapists from the comfort of their home or while not in direct contact with the PT. A device like an insole, implanted with force sensors, which measures different parts of a patient’s foot ...

Design Of A Four Channel Pulsatile Perfusion Bioreactor For Ex-Vivo Study Of Vascular Grafts, Thomas M. Fair

All Theses

Cardiovascular diseases are the leading cause of death in the United States. Atherosclerosis in peripheral arteries is a major contributing factor. Autologous saphenous vein grafts are the most common bypass grafts for treating peripheral artery diseases. A quarter of these grafts fail within a year, and around half have failed within 10 years of the initial surgery. Graft failure is attributed to the development of intimal hyperplasia indicated by the migration and proliferation of vascular smooth muscle cells, fibroblasts, and the deposition of extracellular proteins.

Increases in flow, pressure, the pulse frequency, and the differential of pressure that model an ...

Porous Silicon Photonics For Label-Free Interferometric Biosensing And Flat Optics, Tahmid Hassan Talukdar

All Dissertations

This dissertation uses porous silicon as a material platform to explore novel optical effects in three domains: (i) It studies dispersion engineering in integrated waveguides to achieve high performance group index sensing. With proper design parameters, the sensor waveguides can theoretically achieve 6 times larger group index shift compared to the actual bulk effective refractive index shift. We demonstrate the guided mode confinement factor to be a key parameter in design and implementation of these waveguides. (ii) It explores multicolor laser illumination to experimentally demonstrate perceptually enhanced colorimetric sensing, overcoming the limitations faced by many contemporary colorimetric sensors. Our technique ...

Early Biological Response Of Articular Cartilage To Hemiarthroplasty Wear, Debora Rossetti

Electronic Thesis and Dissertation Repository

Hemiarthroplasties typically result in accelerated wear of the preserved side of the joint, resulting in suboptimal clinical outcomes and limited longevity. This in vitro study investigated the effects of hemiarthroplasty implant curvature on the early biological response of articular cartilage measured by proteoglycan release, histology, and surface morphology. Cartilage from boar radiocarpal joints were worn by metal pins of varying radii of curvature (RoC) using a pin-on-plate wear simulator. Histology and proteoglycan assays showed no significant differences between RoC treatment groups, and proteoglycan assays showed increased proteoglycan release 72 hours after wear testing in worn cartilage specimens compared to control ...

Evaluating The Use Of Nintendo Labo As A Rehabilitation Tool, Jacob Colwell, Logan Suiter, Amanda Wells

ONU Student Research Colloquium

Serious gaming is the practice of using video games, either commercial or specifically designed, for physical rehabilitation. Serious games have emerged in the last decade as a way to increase patient involvement in rehabilitation, increase the likelihood of patients continuing treatment after progress stalls, and generally increase mental health during treatment. However, the current literature has not kept pace with the evolution of technology and therefore the use of next-generation consoles for serious gaming is underdeveloped.

The Nintendo Switch could provide new avenues for serious gaming because of the advanced sensing ability of its controllers (Joy-Cons) and the engaging ways ...

Design And Computational Validation Of A Shear Stress Bioreactor For Conditioning Vascular Tissue To Time-Varying Multidirectional Fluid Shear Stress, Rajeshwari Raja, Philippe Sucosky, Jason Shar

Symposium of Student Scholars

Design and Computational Validation of a Shear Stress Bioreactor for Conditioning Vascular Tissue to Time-Varying Multidirectional Fluid Shear Stress

Author: Rajeshwari Raja Mentor: Dr. Jason A. Shar Department of Mechanical Engineering Kennesaw State University 1100 South Marietta Pkwy SE, 30060

Altered biological environments and conditions, such as microgravity and pregnancy, can impact vascular blood flow and, in turn, generate fluid wall shear stress (WSS; frictional force generated on the tissue surface due to blood flow) abnormalities. These abnormalities are known to affect cardiovascular tissue biology and can be replicated experimentally using a cone-and-plate shear stress bioreactor. This device exposes tissue ...

Senior Subject Gait Analysis Using Self-Supervised Method, Haben Yhdego, Michel Audette

Modeling, Simulation and Visualization Student Capstone Conference

There are many issues regarding the technology used for fall detection gait analysis in the geriatric center of senior patients. The fall detection system used should examine the privacy of the patients and the flexibility of the system. Several researchers have developed fall detection using wearable sensors due to their flexibility and nature of privacy. Most of those developed methods are supervised deep learning methods. However, data annotation is expensive because we use camera video recording and playback of each participant’s recorded video to label the data. Moreover, labelling using a camera recording limits the flexible and private nature ...

Abbott Lab Instrumentation Validation, Brandon James Mukai, Bosung Josh Kim

Biomedical Engineering: Graduate Reports and Projects

Over the past 40 years, since the initial catheter ablation procedure was completed, cardiac mapping has become an essential part of electrophysiological procedures. Cardiac mapping is an electrophysiological study that allows physicians to analyze the electrical activity of the heart in order to diagnose and treat cardiovascular disease. Institutions like Cal Poly can utilize professional instrumentation systems with an appropriate wet lab to develop new devices and study various phenomena in an in-vitro physiological environment. Cardiac mapping systems used in tandem with catheter ablation procedures are essential to ensuring that the trend of deaths due to cardiovascular disease continues to ...

Understanding Healthcare Professionals' Perspectives On Point-Of-Care Testing, Sean Teebagy, Zi-Yue Wang, Denise Dunlap, Connor Saleeba, Danielle Dimezza, Joann Crain, Craig M. Lilly, Bryan Buchholz, David D. Mcmanus, Nathaniel S. Hafer

COVID-19 Publications by UMass Chan Authors

Point-of-care testing (POCT) is an emerging technology that provides crucial assistance in delivering healthcare. The COVID-19 pandemic led to the accelerated importance of POCT technology due to its in-home accessibility. While POCT use and implementation has increased, little research has been published about how healthcare professionals perceive these technologies. The objective of our study was to examine the current perspectives of healthcare professionals towards POCT. We surveyed healthcare professionals to quantify perceptions of POCT usage, adoption, benefits, and concerns between October 2020 and November 2020. Questions regarding POCT perception were assessed on a 5-point Likert Scale. We received a total ...

Technology, Community, And Equity: Considerations For Collecting Social Determinants Data, Aditi Singh, Eric Y. Ding, Jordy Mehawej, Shiksha Joshi, Apurv Soni, Mahasin S. Mujahid

COVID-19 Publications by UMass Chan Authors

Gathering detailed information on an individual’s neighborhood environment is becoming increasingly recognized as a crucial component of understanding the impact that social determinants have on individual and public health, and this has been further highlighted by the ongoing COVID-19 pandemic. Emerging research clearly demonstrates COVID-19’s differential impact on underserved and rural communities, and it is imperative to adequately capture important neighborhood-level predictors of health outcomes to better understand the extent to which these communities have been affected, and to equitably promote their recovery and healing. mHealth tools have drastically transformed the framework of data collection within clinical and ...

3d Bioprinting And Implantation Of Mouse Mammary Epithelial Structures Using A Custom Accessible 3d Bioprinting Platform, Xavier-Lewis Palmer, Saad Jafri, Patrick C. Sachs, Robert D. Bruno

College of Engineering & Technology (Batten) Posters

Prior work has shown that our bioprinting system can reliably produce human mammary organoids and tumoroids with high precision. However, this was not previously applied to mouse models, which are also important with respect to translational research in cancer drug development. To address this, we have produced protocols for the development of in vitro structures from murine mammary epithelial and tumor cells. Additionally, we assessed the translatability of both human and murine bioprinted organoids into mouse mammary fat pads over a period of 6 weeks. Our lab found that our produced organoids are reliable, they can survive in vivo, and ...

Cochlear Implant Training Model, Devin Baughn, Sidney Mingle, Aaron Bowman

Williams Honors College, Honors Research Projects

Currently available training methods for cochlear implant surgeries such as cadavers and imaging systems are expensive and available for a limited number of training sessions. With the goal of decreasing risk factors associated with cochlear implant surgery, our team developed a cochlear implant training model prototype that is designed to provide a trial-and-error, tactile training method for developing force perception levels required to avoid causing damage to the cochlea. This model is designed to utilize a disposable material that ruptures when exposed to critical force levels. A material testing device was developed and utilized to test an assortment of easily ...

The Lognometer: A New Normalized And Computerized Device For Assessing The Neurodevelopment Of Fine Motor Control In Children, Christian O'Reilly, Rejean Plamondon, Nadir Faci

Faculty Publications

Motor skills are fundamental for the development of children. Neurodevelopmental tests currently used by professionals for measuring motor control maturity exhibit several limitations. To address some of these, we have designed the Lognometer, a tablet-based device that can run computerized neuromotor tests. To normalize this tool against a representative population, we collected handwritten triangles from 780 children. We used the Sigma-Lognormal model and a prototype-based parameter estimation algorithm to analyze these movements. To ensure clinical acceptance, we developed an explainable solution relying on statistical regression. We evaluated how well the proposed lognormal decomposition captures the motor control maturation between 6 ...

An Electrochemical, Fluidic, Chip-Based Biosensor For Biomarker Detection, Lauren Bell

Theses and Dissertations--Biomedical Engineering

Biosensors and their use in both the research and clinical field for the detection and monitoring of critical biomarkers are prevalent and constantly improving. However, continued research needs to be done to address shortcomings, such as low sensitivity, poor specificity, and poor readiness for integration into research use and patient care. The objective of this research was to create a combined fluidic, chip-based biosensor that could detect different biomarkers with high sensitivity and ease of use. For assessing the developed sensor, three separate biomarkers were tested: glucose, cholesterol, and oxygen. Both the glucose biosensor and cholesterol biosensor were combined with ...

Totally Tubulair - Adjustable Nasal Cannula, Megan Bruns, Emily Mcgrath, Angelina Marchio, Olivia Renkel

Williams Honors College, Honors Research Projects

Many individuals require short-term and long-term oxygen therapy. These users experience discomfort and problems with the standard nasal cannula that are compounded by issues with oxygen sources being heavy with limited supply and tubing getting tangled, kinked, or not providing enough mobility. The objective of this project was to address ergonomic issues with oxygen therapy devices to increase the ease of use for healthcare workers, patients, and families. By following the engineering design process, a prototype was developed for a nasal cannula with interchangeable prongs. The new design allows users to select a prong size that is more comfortable for ...