Exploring Attacks And Defenses In Additive Manufacturing Processes: Implications In Cyber-Physical Security, 2020 Washington University in St. Louis
Exploring Attacks And Defenses In Additive Manufacturing Processes: Implications In Cyber-Physical Security, Nicholas Deily
Engineering and Applied Science Theses & Dissertations
Many industries are rapidly adopting additive manufacturing (AM) because of the added versatility this technology offers over traditional manufacturing techniques. But with AM, there comes a unique set of security challenges that must be addressed. In particular, the issue of part verification is critically important given the growing reliance of safety-critical systems on 3D printed parts.
In this thesis, the current state of part verification technologies will be examined in the con- text of AM-specific geometric-modification attacks, and an automated tool for 3D printed part verification will be presented. This work will cover: 1) the impacts of malicious attacks on ...
Implementation Of A Computer-Vision System As A Supportive Diagnostic Tool For Parkinson’S Disease, 2020 University of Mississippi
Implementation Of A Computer-Vision System As A Supportive Diagnostic Tool For Parkinson’S Disease, Diego Machado Reyes
Parkinson’s disease is the second most common neurodegenerative disorder, affecting nearly 1 million people in the US and it is predicted that the number will keep increasing. Parkinson’s disease is difficult to diagnose due to its similarity with other diseases that share the parkinsonian symptoms and the subjectivity of its assessment, thus increasing the probabilities of misdiagnosis. Therefore, it is relevant to develop diagnostic tools that are quantitatively based and monitoring tools to improve the patient’s quality of life. Computer-based assessment systems have shown to be successful in this field through diverse approaches that can be classified ...
Theoretical Applicability Of Crispr-Mediated Exon Skipping In Duchenne Muscular Dystrophy, 2020 University of Arkansas, Fayetteville
Theoretical Applicability Of Crispr-Mediated Exon Skipping In Duchenne Muscular Dystrophy, Andrew Greek
Biomedical Engineering Undergraduate Honors Theses
Duchenne muscular dystrophy (DMD) affects approximately 1 in 5,000 males. DMD results from genetic mutations within the gene that interrupts the open reading frame and prematurely truncates the protein. From a non-functional dystrophin protein, DMD results in serious muscle weakening and muscle wasting ultimately leading to death around the age of 26. In some cases of muscular dystrophy, a mutation can occur in areas of the gene that are less essential. In Becker muscular dystrophy (BMD), these mutations cause less significant consequences in phenotype as the dystrophin protein is still semi-functional. With gene editing techniques, it may be possible ...
Synthetic Lethality In Pediatric Brain Cancer Cells By Optimized Plga Nanoparticles And Drug Combinations, 2020 University of Nebraska-Lincoln
Synthetic Lethality In Pediatric Brain Cancer Cells By Optimized Plga Nanoparticles And Drug Combinations, Megan Ruckman, Megan Otte, Forrest Kievit
UCARE Research Products
Here we test drugs effectiveness to inhibit various DNA repair pathways with the purpose of sensitizing cancer cells to radiotherapy. We work on optimizing delivery of DNA repair pathway inhibiting drugs by the use of PLGA nanoparticles.
Ikioo Flying Robot, 2020 California Polytechnic State University, San Luis Obispo
Ikioo Flying Robot, Nicholas Michael Lapidus, Bosung Josh Kim, Jenny Fong
No abstract provided.
Solostand, 2020 California Polytechnic State University, San Luis Obispo
Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso
The purpose of this scope of work is to highlight the progress and development of SoloStand sponsored by Derek Herrera, chief technical officer and founder of SpinalSingularity. SoloStand is an attachment to a wheelchair that will benefit paraplegics that use wheelchairs. A portable and customizable attachment to a wheelchair will allow the user to do everyday tasks without transferring into a separate standing wheelchair and travel more easily. This document outlines everything that has been done in fulfillment of our senior project requirements.
Left Atrial Appendage Printing Process, 2020 California Polytechnic State University, San Luis Obispo
Left Atrial Appendage Printing Process, Areli Reyes, Brandon James Mukai, Mia Noelle Von Knorring
The left atrial appendage senior design team aims to assist in closing off the left atrial appendage that is susceptible to coagulation due to non-valvular atrial fibrillation. Coagulation in the left atrial appendage (LAA) can be life threatening as it can lead to a stroke. Dr. Chris Porterfield performs a procedure that uses the Boston Scientific Watchman to close the appendage. He finds that sizing the Watchman properly is difficult with limited visuals from live CT scans. He proposed converting the CT scans into a 3D printed model of the left atrial appendage and left atrium so he can visually ...
Using An Internal Auditory Stimulus To Activate The Developing Primary Auditory Cortex: A Fetal Fmri Study, 2020 The University of Western Ontario
Using An Internal Auditory Stimulus To Activate The Developing Primary Auditory Cortex: A Fetal Fmri Study, Estee Goldberg
Electronic Thesis and Dissertation Repository
Insight into the rapidly developing brain in utero is scarce. Fetal functional magnetic resonance imaging (fMRI) is a technique used to gain awareness into the developmental process. Previous auditory task-based fMRI studies employed an external sound stimulus directly on the maternal abdomen. However, there has since been recommendation to cease doing so. We sought to investigate a reliable paradigm to study the development of fetal brain networks and postulate that by using an internal stimulus, such as the mother singing, it would result in activation of the fetal primary auditory cortex. Volunteers carrying singleton fetuses with a gestational age of ...
The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, 2020 Virginia Commonwealth University
The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, Michael S. Valentine
Theses and Dissertations
Patients with severe lung pathologies, such as Acute Respiratory Distress Syndrome (ARDS), often require mechanical ventilation as a clinical intervention; however, this procedure frequently exacerbates the original pulmonary issue and produces an exaggerated inflammatory response that potentially leads to sepsis, multisystem organ failure, and mortality. This acute lung injury (ALI) condition has been termed Ventilator-Induced Lung Injury (VILI). Alveolar overdistension, cyclic atelectasis, and biotrauma are the primary injury mechanisms in VILI that lead to the loss of alveolar barrier integrity and pulmonary inflammation. Stress and strains during mechanical ventilation are believed to initiate alveolar epithelial mechanotransduction signaling mechanisms that contribute ...
How Degrees Of Freedom Affects Sense Of Agency, 2019 Chapman University
How Degrees Of Freedom Affects Sense Of Agency, Akima Connelly, Jungsu Pak, Tian Lan, Uri Maoz
Student Scholar Symposium Abstracts and Posters
Can the rubber-hand illusion be extended to a moving robotic arm in different degrees of freedom (DOF), inducing sense of ownership & agency over the arm? We hypothesize that DOF closer to what humans possess will result in a stronger sense of ownership and agency.
Effect Of Corrective Surgery On Lower Limb Mechanics In Patients With Crouch Gait, 2019 Boise State University
Effect Of Corrective Surgery On Lower Limb Mechanics In Patients With Crouch Gait, Adelle Milholland
Boise State University Theses and Dissertations
Crouch gait a progressively degrading gait deviation associated with the neurological disorder cerebral palsy. If left untreated it can lead to anterior knee pain and a loss of ambulation. At present there exists no agreed upon metric for determining the surgical procedures used to treat crouch gait and there is insufficient means to analytically compare the results of different procedures. The aims of this thesis work were to create a pipeline to transform a patient’s gait analysis data into a finite element model, develop a model of sufficient complexity to evaluate a range of outcomes by which to judge ...
Blood Glucose Predictor, 2019 California Polytechnic State University, San Luis Obispo
Blood Glucose Predictor, Jessica Patterson
For my senior project, I perform data analysis using statistical methods to determine body metrics that correlate with blood glucose levels. Working with Dr. Tina Smilkstein, I take repeat measurements from 6 different volunteers to establish trends in bodily metric data. The data taken includes weight, body fat, pulse rate, VO2, blood glucose, blood pressure, hours slept, and quality of sleep. Using these values, I use the program MiniTab to view results.
A few examples of correlations with blood glucose found in this project are:
- Systolic blood pressure for females had a regression line of 124.0 -0.3366*Blood ...
Effect Of Annealing On The Contact Resistance Of Aluminum On A P-Type Substrate, 2019 Singh Center for Nanotechnology
Effect Of Annealing On The Contact Resistance Of Aluminum On A P-Type Substrate, Shrey Shah, George Patrick Watson
Protocols and Reports
Aluminum contacts are widely used to form both ohmic and rectifying contacts. The process to form these contacts involves annealing, thus it is important to study the effect of annealing on the electrical properties of the contacts. Here, we present a way to measure the contact resistance of aluminum contacts formed on a p-type silicon substrate. It was found the contact resistivity decreased by an average of 18%. It was thus found that annealing at 400°C in a forming gas environment improves the electrical properties of aluminum contacts.
Diagnostic Sequence Detection Against A Complex Background Using A Dna Molecular Computation Framework, 2019 University of New Mexico - Main Campus
Diagnostic Sequence Detection Against A Complex Background Using A Dna Molecular Computation Framework, Adan Leon Myers Y Gutierrez
Nanoscience and Microsystems ETDs
Diagnostic assays are designed to detect a unique analyte profile in a disease of interest. Nucleic acids contain an information-dense sequence, and thus are ideal candidates for unique analytes. The gold-standard of nucleic-acid-based detection is PCR which has high sensitivity, but involves time, expertise, and cost. DNA molecular logic technology holds much promise as an alternative molecular detection method due to the potential to save cost and expertise, while also achieving a high sensitivity. However, nucleic acid detection in biomedical applications carries with it the difficulty of choice of appropriate sequence and potential biological sample background.
This work describes the ...
A Framework For Evaluating Cortical Architectural Anomalies In Temporal Lobe Epilepsy Patients, 2019 The University of Western Ontario
A Framework For Evaluating Cortical Architectural Anomalies In Temporal Lobe Epilepsy Patients, Hossein Rajali
Electronic Thesis and Dissertation Repository
Focal cortical dysplasia (FCD) are localized regions of malformed cerebral cortex that are frequently associated with drug-resistant epilepsy. Currently, there is a lack of research towards providing quantitative methods for characterizing minor abnormalities in cortical architecture, hindering efforts to determine whether removal affects surgical outcome, and define potential imaging correlates. In our work, we have developed a tool to extract relevant features associated with cortical architectural abnormalities that can deal with artifacts including cortical layer distortions and morphological differences caused by cortical folding effects, and processing artifacts due to improper sectioning. This framework was applied to detect abnormalities across multiple ...
Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, 2019 The University of Texas at Tyler
Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali
The dry powder inhaler (DPI) is a popular, effective and convenient drug delivery device for inhalation therapy to treat asthma. However, a large quantity (approximately 54%) of inhaled aerosols deposit in the oropharyngeal region. Deposition in this region is undesirable because it provides minimum therapeutic benefits and has adverse localized or systemic side effects. This study reports a method of examining electrostatic charge effects on deposition of three DPI aerosols (Spiriva™ Handihaler, Advair Diskus™, and Pulmicort™ Turbohaler) in a cadaver-based cast of the human oral-pharyngeal-laryngeal (OPL) regions. Experimental aerosols were generated from the three commercially available DPIs by means of ...
Characterization Of Nano-Cellulose Based Composites For Biomedical Applications, 2019 University of Maine
Characterization Of Nano-Cellulose Based Composites For Biomedical Applications, Mitchell P. Chesley
Electronic Theses and Dissertations
The number of orthopedic surgeries performed globally has steadily increased over the past decade due to the standardization of procedures as well as technological advancements. During this time orthopedic devices have been composed predominantly of metals, such as Titanium, Vanadium, Molybdenum, and Stainless steel, as well as their alloys, due to the high strength and durability of these materials. However, metals may, in fact, be suboptimal for orthopedic devices. For example, metals exhibit Young’s modulus much greater than the surrounding bone, inducing localized stress-shielding promoting cortical atrophy, which can lead to osteoporosis. In recent years polymers have been successfully ...
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, 2019 University of Maine
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Electronic Theses and Dissertations
Two-photon microscopy (TPM) is a powerful, versatile imaging modality for the study of biological systems. This thesis overviews the relevant physics involved in TPM, design considerations and process of constructing a home-built, two-photon microscope, and provides a set of procedures to operate the system. Furthermore, this work explores several applications of TPM through the study of single-cell metabolism and imaging the cellular-material interface. Explored in particular depth was the imaging of cellulose nanofiber (CNF) materials, with the goal of understanding the three-dimensional nature of fibroblast cell growth when embedded within the materials. This work uncovered several optical properties of CNF ...
Simulation Of A Continuum Tumor Model Using Distributed Computing., 2019 University of Louisville
Simulation Of A Continuum Tumor Model Using Distributed Computing., Dylan A Goodin
Electronic Theses and Dissertations
Mathematical modeling aims to provide a theoretical framework for understanding tissue dynamics and for establishing treatment response for diseased tissues, such as tumors. Previously published continuum models have successfully represented idealized two-dimensional and three-dimensional tissue for short periods of time. A recently published continuum model of cancer increases model complexity and describes three-dimensional tissue that, due to the required complexity of the geometric multigrid solver, can only be feasibly applied to millimeter-scale simulations. Furthermore, the computational cost for such models has hindered their application in the laboratory and in the clinic. With computational demands greatly outpacing current openMP-based approaches on ...
The Effect Of Radial Head Hemiarthroplasty Stem Fit On Radiocapitellar Contact Mechanics: Is Loose Fit Better Than Rigidly Fixed?, Jakub Szmit, Graham J.W. King, James A. Johnson, G. Daniel G. Langohr
Western Research Forum
Background/Methods: Radial head hemiarthroplasty is commonly employed to manage comminuted displaced fractures. With regards to implant fixation, current designs vary with some prostheses aiming to achieve a tight 'fixed' fit, and others utilizing a smooth stem with an over reamed 'loose' fit. The purpose of the present study was to evaluate the effect of radial head hemiarthroplasty stem fit on radiocapitellar contact using a finite element model which simulated both fixed (size-for-size) and loose (1, 2 & 3mm over reamed) stem fits.
Hypothesis: It was hypothesized that a loose stem fit would improve radiocapitellar contact mechanics, with increased contact area ...