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A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox Mr 2016 University of Maine

A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox Mr

Electronic Theses and Dissertations

We explored the capabilities of additive manufacturing using a photo-cured jetted material 3D printer to manufacture a milli-microfluidic device with direct application in microalgae Dunaliella sp growth and intracellular compounds biosynthesis tests. A continuous microbioreactor for microalgae culture was CAD designed and successfully built in 1 hour and 49 minutes using black photopolymer cured by UV and a support material. The microreactor was made up of 2 parts including the bioreactor itself and a microchannel network for culture media fluids and microalgae. Both parts were assembled to form a single unit. Additional optical and auxiliar components were added. An external ...


Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff 2016 University of Nebraska - Lincoln

Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff

Computer Science and Engineering: Theses, Dissertations, and Student Research

Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit them for novel purposes, such as the development of ubiquitous and heterogeneous communication networks to interconnect biological cells with nano and biotechnology-enabled devices, i.e., the Internet of Bio-Nano Things. One major problem in realizing these goals stands in the development of reliable techniques to control the engineered cells and their behavior from ...


Performance Factors In Neurosurgical Simulation And Augmented Reality Image Guidance, Ryan Armstrong 2016 The University of Western Ontario

Performance Factors In Neurosurgical Simulation And Augmented Reality Image Guidance, Ryan Armstrong

Electronic Thesis and Dissertation Repository

Virtual reality surgical simulators have seen widespread adoption in an effort to provide safe, cost-effective and realistic practice of surgical skills. However, the majority of these simulators focus on training low-level technical skills, providing only prototypical surgical cases. For many complex procedures, this approach is deficient in representing anatomical variations that present clinically, failing to challenge users’ higher-level cognitive skills important for navigation and targeting. Surgical simulators offer the means to not only simulate any case conceivable, but to test novel approaches and examine factors that influence performance. Unfortunately, there is a void in the literature surrounding these questions. This ...


Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson 2016 University of Tennessee - Knoxville

Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson

Michael Johnson

Osteoarthritis (OA) of the knee is one of the leading causes of chronic disability (along with the hip). Due to rising healthcare costs associated with OA, it is important to fully understand the disease and how it progresses in the knee. One symptom of knee OA is the degeneration of cartilage in the articulating knee. The cartilage pad plays a major role in painting the biomechanical picture of the knee. This work attempts to quantify the cartilage thickness of healthy male and female knees using statistical shape models (SSMs) for a deep knee bend activity. Additionally, novel cartilage segmentation from ...


Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson 2016 University of Tennessee - Knoxville

Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson

Michael Johnson

Osteoarthritis (OA) of the knee is one of the leading causes of chronic disability (along with the hip). Due to rising healthcare costs associated with OA, it is important to fully understand the disease and how it progresses in the knee. One symptom of knee OA is the degeneration of cartilage in the articulating knee. The cartilage pad plays a major role in painting the biomechanical picture of the knee. This work attempts to quantify the cartilage thickness of healthy male and female knees using statistical shape models (SSMs) for a deep knee bend activity. Additionally, novel cartilage segmentation from ...


Evaluation System For Craniosynostosis Surgeries With Computer Simulation And Statistical Modelling, Jing Jin 2016 The University of Western Ontario

Evaluation System For Craniosynostosis Surgeries With Computer Simulation And Statistical Modelling, Jing Jin

Electronic Thesis and Dissertation Repository

Craniosynostosis is a pathology in infants when one or more sutures prematurely closed, leading to abnormal skull shape. It has been classified according to the specific suture that has been closed, each of which has a typical skull shape. Surgery is the common treatment to correct the deformed skull shape and to reduce the excessive intracranial pressure. Since every case is unique, the cranial facial teams have difficulties to select an optimum solution for a specific patient from multiple options. In addition, there is not an appropriate quantified measurement existed currently to help cranial facial team to quantitatively evaluate their ...


Technology Transfer: A View From The Trenches, Harvey Drucker 2016 University of New Hampshire

Technology Transfer: A View From The Trenches, Harvey Drucker

RISK: Health, Safety & Environment

Dr. Drucker, who has lab-wide responsibility for technology transfer at Argonne National Laboratory, argues that transferring rights in discoveries made through tax supported research to private entities can contribute to public welfare in many ways.


Overview Of Federal Technology Transfer, Lawrence Rudolph 2016 University of New Hampshire

Overview Of Federal Technology Transfer, Lawrence Rudolph

RISK: Health, Safety & Environment

Mr. Rudolph reviews approximately thirteen years of legal and political developments that have contributed to laws governing the extent to which private firms may secure rights in technology at least partly developed with federal funds.


Microfluidic Cantilever Detects Bacteria And Measures Their Susceptibility To Antibiotics In Small Confined Volumes, Hashem Etayash, M. F. Khan, Kamaljit Kaur, Thomas Thundat 2016 University of Alberta

Microfluidic Cantilever Detects Bacteria And Measures Their Susceptibility To Antibiotics In Small Confined Volumes, Hashem Etayash, M. F. Khan, Kamaljit Kaur, Thomas Thundat

Pharmacy Faculty Articles and Research

In the fight against drug-resistant bacteria, accurate and high-throughput detection is essential. Here, a bimaterial microcantilever with an embedded microfluidic channel with internal surfaces chemically or physically functionalized with receptors selectively captures the bacteria passing through the channel. Bacterial adsorption inside the cantilever results in changes in the resonance frequency (mass) and cantilever deflection (adsorption stress). The excitation of trapped bacteria using infrared radiation (IR) causes the cantilever to deflect in proportion to the infrared absorption of the bacteria, providing a nanomechanical infrared spectrum for selective identification. We demonstrate the in situ detection and discrimination of Listeria monocytogenes at a ...


Next Generation In-Vivo Forward Solution Physiological Model Of The Human Lower Limb To Predict Implanted Knee Mechanics, Bradley Allen Meccia 2016 University of Tennessee, Knoxville

Next Generation In-Vivo Forward Solution Physiological Model Of The Human Lower Limb To Predict Implanted Knee Mechanics, Bradley Allen Meccia

Doctoral Dissertations

Current total knee arthroplasty (TKA) evaluation methods are both time consuming and expensive. They require fabrication of the TKA and then utilize a wear or cadaveric simulator which does not necessarily replicate in-vivo conditions. Other analysis methods involve following the long-term success of TKA in subjects for five or more years. Mathematical modeling of TKA provide an efficient method at a greatly reduced cost for evaluating TKA. Obviously, the accuracy of a mathematical model is extremely important to the validity of the results.

Mathematical modeling of the knee faces many difficulties. The number of muscles actuating the knee is much ...


Functional Vasodilation And Vascular Reactivity In Arteriolar Collaterals In The Spinotrapezius Of Males And Females, Britta C. Nelson 2016 California Polytechnic State University, San Luis Obispo

Functional Vasodilation And Vascular Reactivity In Arteriolar Collaterals In The Spinotrapezius Of Males And Females, Britta C. Nelson

Biomedical Eng/General Eng.

Peripheral arterial occlusive disease (PAOD) occurs when there is narrowing or blockage of the peripheral arteries that carry blood to the extremities, most commonly the legs. The most common symptom of PAOD is intermittent claudication, or ischemic pain during exercise. Women with PAOD experience a greater extremity functional impairment than men. Since impaired vasodilation might cause the ischemic pain from PAOD, we should evaluate vasodilation post ligation in males and females in collateral vessels, which connect two arterial segments to maintain blood flow to an otherwise hypoxic area. First, we need to examine collateral vasodilation in unoperated male and female ...


Portable Sensory Room For The West Orange County Consortium For Special Education, Lindsey Chase, Emma Eskildsen, Alex Fox, Claire Francis, Nate Hoffman, Kaylee Keck, Sarah Sullivan 2016 California Polytechnic State University, San Luis Obispo

Portable Sensory Room For The West Orange County Consortium For Special Education, Lindsey Chase, Emma Eskildsen, Alex Fox, Claire Francis, Nate Hoffman, Kaylee Keck, Sarah Sullivan

Biomedical Eng/General Eng.

This report discusses the development of a Portable Sensory Room to be used at Newland Elementary School in Huntington Beach. Newland Elementary has an exceptional Special Needs program that teaches the children with the most severe cases of autism in its school district. People with autism typically also have sensory processing disorders, which can be extremely disruptive for a child’s development and can make it difficult for a child to be able to concentrate long enough to gain necessary life skills. The idea behind a Sensory Rooms is to create a place to calm the students and to expose ...


Prosthetic Leg Kit For Deployment In Developing Countries, Brian Murphy, Dominique Porcincula, Derek Morgan, Kendall Ruggles, Christian Aguayo 2016 California Polytechnic State University, San Luis Obispo

Prosthetic Leg Kit For Deployment In Developing Countries, Brian Murphy, Dominique Porcincula, Derek Morgan, Kendall Ruggles, Christian Aguayo

Biomedical Eng/General Eng.

The World Health Organization estimates that over 30 million people require some sort of prosthetic technology. However, traditional prosthetic fitting practices take a lot of time and cost a lot of money, making them inaccessible to millions of people around the world. StandUP Worldwide is an interdisciplinary project team devoted to creating low-cost prosthetic technologies for use around the world, especially in resource poor areas. They are currently developing a low cost, below-the-knee prosthetic kit that can be easily deployed in a resource-poor area. The following presents their solution for a below-the-knee prosthetic socket, foot, and leg.


Optimized Protocol For Measuring 2-Nbdg Uptake As A Cellular Marker Of Glycolytic Demand, Drew Folgmann 2016 University of Arkansas, Fayetteville

Optimized Protocol For Measuring 2-Nbdg Uptake As A Cellular Marker Of Glycolytic Demand, Drew Folgmann

Biomedical Engineering Undergraduate Honors Theses

2[N-(7-nitrobenz-2-oxa-1,2-diaxol-4-yl)amino]-2-deoxyglucose (2-NBDG) a fluorescently tagged analog of FDG is ideal for in vitro studies and imaging. 2-NBDG has been proven to be an adequate marker for glucose uptake in many different types of cells [1]. However, across the spectrum of 2-NBDG use a lack of consensus is observed for the following questions. What is the ideal time to fast cells to optimize cellular uptake of 2-NBDG? Also, what is the ideal concentration of 2-NBDG to be used when quantifying glucose uptake? Finally, what is the effect of serum on the uptake of 2-NBDG? To answer ...


Non-Directional Conjugation Of Fluorescent Antibodies To Gold Nanoparticles For Stem Cell Therapy, Kunal B. Shah 2016 University of Arkansas, Fayetteville

Non-Directional Conjugation Of Fluorescent Antibodies To Gold Nanoparticles For Stem Cell Therapy, Kunal B. Shah

Biomedical Engineering Undergraduate Honors Theses

The objective of this study was to design citrate-coated gold nanoparticles conjugated with FITC-IgG, a fluorescent antibody, and to qualitatively and quantitatively measure the resulting fluorescent emission. Optical properties of the gold nanoparticles were measured at various stages to provide evidence of successful conjugation. The absorbance spectrum of the citrate gold nanoparticles was compared to that of the reaction mixture containing the gold nanoparticles and the FITC-IgG. A noticeable broadening of the absorption peak was observed at 519 nm indicating a surface modification of the gold nanoparticles. Fluorescence data was obtained with a fluorospectrometer and revealed a significant amount of ...


Crizotinib And Ceritinib Induce Apoptosis And Necrosis In Primary Rat Hepatocytes With Distinct Capacity, Alec T. Salminen 2016 University of Arkansas, Fayetteville

Crizotinib And Ceritinib Induce Apoptosis And Necrosis In Primary Rat Hepatocytes With Distinct Capacity, Alec T. Salminen

Biomedical Engineering Undergraduate Honors Theses

Drug development makes up a major portion of biomedical engineering research interests. The FDA oversees the introduction, experimentation, and implementation of all drugs before market approval is granted. Even after market approval is granted, the FDA continues to monitor the safety of all drugs. Crizotinib and ceritinib are two anaplastic lymphoma kinase (ALK) inhibitors recently approved by the FDA. Both drugs are indicated for treatment of non-small cell lung cancers (NSCLC) with abnormal ALK gene, and they are approved with a companion diagnostic test that determines ALK abnormality. Clinical trial data suggest that crizotinib and ceritinib can cause liver injury ...


Design Of Exercise Equipment For Wheelchair Users: A Case Study In Accessibility Standards, Kate Craddock Rescsanszky 2016 University of Connecticut

Design Of Exercise Equipment For Wheelchair Users: A Case Study In Accessibility Standards, Kate Craddock Rescsanszky

Honors Scholar Theses

Engineers must consider a number of aspects of every project they work on. Accessibility is one aspect that presents a unique challenge. Rather than being based on absolute material parameters, accessibility is based on how people interact with technology and their built environment. Since 1990, the Americans with Disabilities Act has been the predominant standard in accessibility because of its wide reach and legal mandate. In addition to the ADA, the ASTM and the Institute for Universal Design offer helpful guidelines for designing for accessibility. However, in addition to standards, guidelines, and recommendations, it is important to consult the intended ...


Magnetism Of Magnetite Nanoparticles As Determined By Mössbauer Spectroscopy, Hien-Yoong Hah 2016 University of Tennessee - Knoxville

Magnetism Of Magnetite Nanoparticles As Determined By Mössbauer Spectroscopy, Hien-Yoong Hah

Masters Theses

Fe3O4 [Magnetite] nanoparticles have magnetism that differs greatly from their bulk counterparts. Whereas bulk Fe3O4 is a ferrimagnet, single-domain Fe3O4 nanoparticles have been found to be superparamagnetic. This allows for increased magnetization of the nanoparticles compared to the bulk when in a magnetic field. For most paramagnets, magnetization requires applied fields of a few Tesla at low temperatures. This is achievable through the application of superconducting magnets. In superparamagnets, the high susceptibility of the particles allows magnetization through a Nd-Fe-B permanent magnet at room temperature. This is caused by an increased ...


Identification Of A Rational, Physiologically Based Early Biomarker And Pathogenic Pathway For Preeclampsia, Mark K. Santillan 2016 University of Iowa

Identification Of A Rational, Physiologically Based Early Biomarker And Pathogenic Pathway For Preeclampsia, Mark K. Santillan

Theses and Dissertations

Preeclampsia is a hypertensive disorder of pregnancy that is diagnosed after the 20th week of gestation. It is defined by the American College of Obstetrics and Gynecology as de novo hypertension of at least 140/90 in a pregnant woman. Proteinuria with the hypertension is sufficient but not required for the diagnosis, especially if a woman displays severe symptoms such as headache, blurry vision, right upper quadrant pain, and low platelet count. Despite significant research, preeclampsia continues to kill 76,000 mothers and 500,000 babies per year worldwide. It causes short and long term consequences such as future metabolic ...


Circle Of Willis Model For Transcranial Doppler Ultrasound Training, Conner J. Beyersdorf, Ben Hage, Greg Bashford 2016 University of Nebraska-Lincoln

Circle Of Willis Model For Transcranial Doppler Ultrasound Training, Conner J. Beyersdorf, Ben Hage, Greg Bashford

UCARE Research Products

Transcranial Doppler (TCD) ultrasound is a technique involving the use of high frequency transmitters to measure intracranial blood flow. The brain is supplied by blood in an arterial anastomosis called the Circle of Willis. Using TCD ultrasound on the circle is difficult and requires practice and teaching. A functional model of the Circle of Willis could prove to be a valuable teaching tool. Through the use of AutoCAD and 3D printing software, an anatomically accurate model was created and set in gelatin phantom inside of a plastic skull. Milk was pumped through the model with a peristaltic pump to simulate ...


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