University of Pennsylvania
University of Arkansas, Fayetteville
California Polytechnic State University, San Luis Obispo
University of Connecticut - Storrs
University of Nebraska-Lincoln
The University of Western Ontario
University of Tennessee - Knoxville
University of Kentucky
Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance,
2023
California Polytechnic State University, San Luis Obispo
Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian
Biomedical Engineering: Graduate Reports and Projects
As the prevalence of cardiovascular diseases continues to exponentially grow in populations across the globe, the necessity of determining underlying factors, effective methods of diagnoses, and universally available preventive measures also grows. Early detection of endothelial dysfunction, a proven precursor of cardiovascular diseases, can be extremely impactful in encouraging preventative measures and early intervention before medical conditions become chronic. In recent years, ice plunging, a form of cryotherapy involving full body immersion in cold water, has gained popularity within circles of fitness and health practitioners, gaining the interest of people of all backgrounds. Certain parallels observed between the human physiological …
Controlled Radiation Capsule For Precision And Rapid Cancer Treatment,
2023
Kennesaw State University
Controlled Radiation Capsule For Precision And Rapid Cancer Treatment, Hoseon Lee, Zsolt Kollar, Bailey R. White, Junia Nguyen, David Roque, Sowjanya Palagani
Symposium of Student Scholars
This research aims to transform cancer treatment through the optimization of brachytherapy, with a focus on reducing treatment duration, setup complexities, and financial burdens, all while emphasizing patient safety. Patients living at a distance from radiation clinics, particularly those undergoing extended Low Dose Radiation brachytherapy, often struggle with the formidable financial challenges associated with securing nearby accommodations. In response to these issues, the research introduces a radiation capsule designed to condense the conventional six-month treatment period to approximately just one week, thereby significantly reducing the duration of required accommodations. This capsule is especially relevant considering the construction cost of $40 …
Corrosion Of Implant Materials In The Human Body,
2023
Western University
Corrosion Of Implant Materials In The Human Body, Maedeh Barzmehri
Corrosion Research
This paper extensively examines the complex problem of implant corrosion occurring within the human body. The corrosion of implants gives rise to substantial challenges, encompassing compromised implant durability, patient safety concerns, and potential adverse impacts on the long-term functionality of the medical device. The study's primary objectives include offering a concise overview of the various corrosion mechanisms that impact a range of implant materials and outlining health complications linked to the byproducts of implant corrosion. Furthermore, it delves into a cost analysis specific to hip or knee revision arthroplasty, which has become a prevalent scenario in implant failure cases on …
Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance,
2023
California Polytechnic State University, San Luis Obispo
Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian
Master's Theses
As the prevalence of cardiovascular diseases continues to exponentially grow in populations across the globe, the necessity of determining underlying factors, effective methods of diagnoses, and universally available preventive measures also grows. Early detection of endothelial dysfunction, a proven precursor of cardiovascular diseases, can be extremely impactful in encouraging preventative measures and early intervention before medical conditions become chronic. In recent years, ice plunging, a form of cryotherapy involving full body immersion in cold water, has gained popularity within circles of fitness and health practitioners, gaining the interest of people of all backgrounds. Certain parallels observed between the human physiological …
Hierarchical Based Classifcation Method Based On Fusion Ofgaussian Map Descriptors Foralzheimer Diagnosis Using T1‑Weighted Magnetic Resonance Imaging,
2023
The British University in Egypt
Hierarchical Based Classifcation Method Based On Fusion Ofgaussian Map Descriptors Foralzheimer Diagnosis Using T1‑Weighted Magnetic Resonance Imaging, Nourhan Zayed, Shereen E. Morsy, Inas A. Yassine
Mechanical Engineering
Alzheimer’s disease (AD) is considered one of the most spouting elderly diseases. In 2015, AD is reported the US’s sixth cause of death. Substantially, non-invasive imaging is widely employed to provide biomarkers supporting AD screening, diagnosis, and progression. In this study, Gaussian descriptors-based features are proposed to be efcient new biomarkers using Magnetic Resonance Imaging (MRI) T1-weighted images to diferentiate between Alzheimer’s disease (AD), Mild Cognitive Impairment (MCI), and Normal controls (NC). Several Gaussian map-based features are extracted such as Gaussian shape operator, Gaussian curvature, and mean curvature. The aforementioned features are then introduced to the Support Vector Machine (SVM). …
Longitudinal Case-Control Study Of Mammographic Breast Tissue Subtypes,
2023
University of Maine
Longitudinal Case-Control Study Of Mammographic Breast Tissue Subtypes, Kendra Batchelder
Electronic Theses and Dissertations
Breast density is a known risk factor for breast cancer. However, there has been limited research on potential subtypes of mammographic dense breast tissue to identify areas of active dense tissue that is structurally reorganizing and links to cancer dynamics, versus areas of passive dense tissue which remains organized. We hypothesize that the amounts of subtypes of mammographic dense tissue and the associated rate of change through time could provide insights into breast cancer risk. A retrospective study was conducted to investigate breast cancer using longitudinal screening mammograms and accompanying pathology reports collected in 2015. Patients were matched by age …
Investigating The Potential Of A Cell-Based Gene Editing Therapy For Inherited Metabolic Liver Disease,
2023
Clemson University
Investigating The Potential Of A Cell-Based Gene Editing Therapy For Inherited Metabolic Liver Disease, Ilayda Ates
All Dissertations
Inherited metabolic diseases (IMDs) affecting the liver are relatively rare but collectively have a prevalence of 1 in 800 live births. These diseases result from autosomal recessive single-gene mutations, leading to organ dysfunction and potentially fatal consequences if left untreated. One potential therapeutic strategy for IMDs of the liver involves using CRISPR-Cas9-induced loss of function mutations. However, translating this approach into the clinic is limited by the need for safe and effective CRISPR delivery methods. Adeno-associated viral vectors (AAVs), commonly used for CRISPR delivery, are associated with significant safety and efficacy concerns, including risks for immunogenicity, off-target mutagenesis, and genotoxicity …
The Effects Of Compression Wrapping Techniques And Primary Wound Dressings On Leg Skin Interface Pressure,
2023
Clemson University
The Effects Of Compression Wrapping Techniques And Primary Wound Dressings On Leg Skin Interface Pressure, James Cox
All Theses
Peripheral edema affects approximately 20% of people in the US over the age of 50 and is frequently encountered among individuals with conditions such as heart disease, prolonged immobility, and venous insufficiency.1 Compression is an established therapeutic tool utilized for the management of several chronic edema presentations including lymphedema and venous leg ulcers.2,3 Therapeutic efficacy of compressive applications can be evaluated by defining interface pressure (IP) and IP distributions associated with specific textile combinations.2 During compressive applications where an open wound is present, primary wound dressings should be used in combination with compressive wraps. Primary wound dressings …
Static Vascular Modeling Of Diabetes Progression,
2023
California Polytechnic State University, San Luis Obispo
Static Vascular Modeling Of Diabetes Progression, Andrea Skattenborg
Master's Theses
Cardiovascular disease is the leading cause of mortality in diabetic patients, and diabetes is one of the main causes of cardiovascular disease. Risk factors for cardiovascular disease result in structural and functional changes in the vascular wall. Arterial stiffness is a prominent structural change observed in the arterial wall that can be measured in clinical settings. The purpose of this thesis was to create a static model of the changes in arterial stiffness seen in diabetes. Elastic tubes with varying wall thicknesses were used to create artificial arteries for this purpose. Compliance (inverse of stiffness) of the arteries was determined …
Motion-Resistant Pulse Oximetry,
2023
New Jersey Institute of Technology
Motion-Resistant Pulse Oximetry, Ludvik Alkhoury
Dissertations
The measurement of vital signs ? such as peripheral capillary oxygen saturation (SpO2) and heart rate (HR) levels ? by a pulse oximeter is studied. The pulse oximeter is a non-invasive device that measures photoplethysmography (PPG) signals and extracts vital signs from them. However, the quality of the PPG signal measured by oximetry sensors is known to deteriorate in the presence of substantial human and sensor movements contributing to the measurement noise. Methods to suppress such noise from PPG signals measured by an oximeter and to calculate the associated vital signs with high accuracy even when the wearer …
Dual Color Optogenetic Control For Analyzing Cardiac Function In Drosophila,
2023
Washington University in St. Louis
Dual Color Optogenetic Control For Analyzing Cardiac Function In Drosophila, Jiantao Zhu
McKelvey School of Engineering Theses & Dissertations
Prolonged consumption of carbohydrate-rich diets and immobile lifestyles frequently cause metabolic disorders and obesity and, as a result, may lead to progressive heart dysfunction among broad social groups of the population. Drosophila melanogaster serves as an essential model organism in cardiovascular disease research due to conserved physiological and genomic traits shared with humans, its genetic and molecular toolbox versatility, and cost-effective maintenance. Here, we combine optogenetics and optical coherence tomography to study cardiovascular function in D. melanogaster. A new optogenetic pacing system has been developed, employing a transgenic line carrying two opsins: ChR2 and NpHR2.0. A custom-built hardware setup …
Antimicrobial Activity And Mechanism Of Amyloid Proteins And Synthetic Conjugated Polyelectrolytes,
2023
University of New Mexico - Main Campus
Antimicrobial Activity And Mechanism Of Amyloid Proteins And Synthetic Conjugated Polyelectrolytes, Fahimeh Maghsoodi
Nanoscience and Microsystems ETDs
Although the exact cause of Alzheimer’s disease (AD) is still unknown, it is widely considered that the accumulation of amyloid plaques composed of the amyloid-β (Aβ) peptide in the brain is linked to neurodegeneration. Co-localization of viral DNA with Aβ plaques, the association of brain infection and AD, and research indicating the protective effect of Aβ against bacteria and fungi in mice and human cells have led to the hypothesis that Aβ expression and deposition may be central to its function as an antimicrobial peptide (AMP). In my thesis research, we seek to elucidate how Aβ functions as an AMP …
Hybrid Power Spectral And Wavelet Image Roughness Analysis,
2023
University of Maine
Hybrid Power Spectral And Wavelet Image Roughness Analysis, Basel White
Electronic Theses and Dissertations
The Two-Dimensional Wavelet Transform Modulus Maxima (2D WTMM) sliding window methodology has proven to be a robust approach, in particular for the extraction of the Hurst (H) roughness exponent from grayscale mammograms. The power spectrum is a computational analysis based on the Fourier transform that can be used to estimate the roughness of a scale-invariant image or region via the calculation of H. We aim to examine how the calculation of H in fractional Brownian motion (fBm) images and mammograms can be improved. fBm images are generated for H ∈ [0.00,1.00] for testing through the previous 2D …
Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement,
2023
University of Mississippi
Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement, Sydney Ruth Rester, Shelby Lynn Berry
Honors Theses
Seniors at the University of Mississippi studying biomedical engineering complete a senior project that seeks to solve a problem in healthcare. Our team, composed of Sydney Rester, Shelby Berry, Andrew Ulmer, and Alex Bromley, sought to improve care associated with nasogastric feeding tubes. We identified two major problems: clogging and tube dislodgement. To address the problem of dislodgement, the team crafted a new feeding tube design with a balloon attachment. The attachment prevents a patient from pulling the feeding tube out and keeps the tube from dislodging due to normal patient movement. We further determined that our tube should be …
Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement,
2023
University of Mississippi
Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement, Shelby Lynn Berry, Sydney Ruth Rester
Honors Theses
Seniors at the University of Mississippi studying biomedical engineering complete a senior project that seeks to solve a problem in healthcare. Our team, composed of Sydney Rester, Shelby Berry, Andrew Ulmer, and Alex Bromley, sought to improve care associated with nasogastric feeding tubes. We identified two major problems: clogging and tube dislodgement. To address the problem of dislodgement, the team crafted a new feeding tube design with a balloon attachment. The attachment prevents a patient from pulling the feeding tube out and keeps the tube from dislodging due to normal patient movement. We further determined that our tube should be …
Development And Implementation Of A Computational Modeling Tool For Evaluation Of Tha Component Position,
2023
University of Tennessee, Knoxville
Development And Implementation Of A Computational Modeling Tool For Evaluation Of Tha Component Position, Thang Dac Nguyen
Doctoral Dissertations
The human body is a complicated structure with muscles, ligaments, bones, and joints. Modeling human body with computational tools are becoming a trend [1]. More importantly, using computational tools to evaluate human body is a non-invasive technique that could help surgeons and researchers evaluate implant products [2]. Therefore, the development of a model which can analyze both implant sizing suggestion and kinematics of subject specific data could prove valuable. For total hip arthroplasty, one common complication is in vivo separation and dislocation of the femoral head within the acetabular cup [3] [4]. Developing a successful computational tool to address this …
Investigating Myosin Ensemble Force Generation Using Optical Tweezers,
2023
University of Mississippi
Investigating Myosin Ensemble Force Generation Using Optical Tweezers, Janie Watts
Honors Theses
Myosin is a motor protein that facilitates muscle contraction and movement by stepping along actin filaments using energy from ATP hydrolysis. If myosin or other motors are disrupted throughout the body, it can have many harmful effects. Hypertrophic cardiomyopathy is a disease caused by gene mutations that affect myosin heavy chains in the heart. The tissue of the heart becomes abnormally thick, which can make it more difficult to pump blood or block blood flow out of the heart. Our goal is to discern the mechanistic difference function of a healthy and diseased heart. To accomplish this, we construct model …
Counterventions: A Reparative Reflection On Interventionist Hci,
2023
Purdue University
Counterventions: A Reparative Reflection On Interventionist Hci, Rua Mae Williams, Louanne E. Boyd, Juan E. Gilbert
Engineering Faculty Articles and Research
Research in HCI applied to clinical interventions relies on normative assumptions about which bodies and minds are healthy, valuable, and desirable. To disrupt this normalizing drive in HCI, we define a “counterventional approach” to intervention technology design informed by critical scholarship and community perspectives. This approach is meant to unsettle normative assumptions of intervention as urgent, necessary, and curative. We begin with a historical overview of intervention in HCI and its critics. Then, through reparative readings of past HCI projects in autism intervention, we illustrate the emergent principles of a counterventional approach and how it may manifest research outcomes that …
Split And Join: An Efficient Approach For Simulating Stapled Intestinal Anastomosis In Virtual Reality,
2023
Chapman University
Split And Join: An Efficient Approach For Simulating Stapled Intestinal Anastomosis In Virtual Reality, Di Qi, Suvranu De
Engineering Faculty Articles and Research
Colorectal cancer is a life-threatening disease. It is the second leading cause of cancer-related deaths in the United States. Stapled anastomosis is a rapid treatment for colorectal cancer and other intestinal diseases and has become an integral part of routine surgical practice. However, to the best of our knowledge, there is no existing work simulating intestinal anastomosis that often involves sophisticated soft tissue manipulations such as cutting and stitching. In this paper, for the first time, we propose a novel split and join approach to simulate a side-to-side stapled intestinal anastomosis in virtual reality. We mimic the intestine model using …
Developing A Finite Element Model For Evaluating The Posterior Tibial Slope In A Medial Opening Wedge High Tibial Osteotomy,
2023
The University of Western Ontario
Developing A Finite Element Model For Evaluating The Posterior Tibial Slope In A Medial Opening Wedge High Tibial Osteotomy, Victor Alexander Carranza
Electronic Thesis and Dissertation Repository
This thesis aimed to develop and validate a computation finite element (FE) model to investigate the effect of hinge axis orientation on the posterior tibial slope (PTS) and mechanical medial proximal tibial angle (mMPTA) while analyzing the mechanical response around the hinge in a medial opening wedge high tibial osteotomy (MOWHTO). Chapter 2 highlights the importance of selecting an appropriate modeling method that best represents the clinical scenario. Chapter 3 validated a FE model using the Bland-Altman agreement analysis which yielded 95% limits of agreement of −0.9° to 1.2° for PTS and −1.4° to 1.9° for mMPTA. A parametric study …
