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Next Generation In-Vivo Forward Solution Physiological Model Of The Human Lower Limb To Predict Implanted Knee Mechanics, Bradley Allen Meccia 2016 University of Tennessee, Knoxville

Next Generation In-Vivo Forward Solution Physiological Model Of The Human Lower Limb To Predict Implanted Knee Mechanics, Bradley Allen Meccia

Doctoral Dissertations

Current total knee arthroplasty (TKA) evaluation methods are both time consuming and expensive. They require fabrication of the TKA and then utilize a wear or cadaveric simulator which does not necessarily replicate in-vivo conditions. Other analysis methods involve following the long-term success of TKA in subjects for five or more years. Mathematical modeling of TKA provide an efficient method at a greatly reduced cost for evaluating TKA. Obviously, the accuracy of a mathematical model is extremely important to the validity of the results.

Mathematical modeling of the knee faces many difficulties. The number of muscles actuating the knee is much ...


Prosthetic Leg Kit For Deployment In Developing Countries, Brian Murphy, Dominique Porcincula, Derek Morgan, Kendall Ruggles, Christian Aguayo 2016 California Polytechnic State University, San Luis Obispo

Prosthetic Leg Kit For Deployment In Developing Countries, Brian Murphy, Dominique Porcincula, Derek Morgan, Kendall Ruggles, Christian Aguayo

Biomedical Eng/General Eng.

The World Health Organization estimates that over 30 million people require some sort of prosthetic technology. However, traditional prosthetic fitting practices take a lot of time and cost a lot of money, making them inaccessible to millions of people around the world. StandUP Worldwide is an interdisciplinary project team devoted to creating low-cost prosthetic technologies for use around the world, especially in resource poor areas. They are currently developing a low cost, below-the-knee prosthetic kit that can be easily deployed in a resource-poor area. The following presents their solution for a below-the-knee prosthetic socket, foot, and leg.


Portable Sensory Room For The West Orange County Consortium For Special Education, Lindsey Chase, Emma Eskildsen, Alex Fox, Claire Francis, Nate Hoffman, Kaylee Keck, Sarah Sullivan 2016 California Polytechnic State University, San Luis Obispo

Portable Sensory Room For The West Orange County Consortium For Special Education, Lindsey Chase, Emma Eskildsen, Alex Fox, Claire Francis, Nate Hoffman, Kaylee Keck, Sarah Sullivan

Biomedical Eng/General Eng.

This report discusses the development of a Portable Sensory Room to be used at Newland Elementary School in Huntington Beach. Newland Elementary has an exceptional Special Needs program that teaches the children with the most severe cases of autism in its school district. People with autism typically also have sensory processing disorders, which can be extremely disruptive for a child’s development and can make it difficult for a child to be able to concentrate long enough to gain necessary life skills. The idea behind a Sensory Rooms is to create a place to calm the students and to expose ...


Identification Of A Rational, Physiologically Based Early Biomarker And Pathogenic Pathway For Preeclampsia, Mark K. Santillan 2016 University of Iowa

Identification Of A Rational, Physiologically Based Early Biomarker And Pathogenic Pathway For Preeclampsia, Mark K. Santillan

Theses and Dissertations

Preeclampsia is a hypertensive disorder of pregnancy that is diagnosed after the 20th week of gestation. It is defined by the American College of Obstetrics and Gynecology as de novo hypertension of at least 140/90 in a pregnant woman. Proteinuria with the hypertension is sufficient but not required for the diagnosis, especially if a woman displays severe symptoms such as headache, blurry vision, right upper quadrant pain, and low platelet count. Despite significant research, preeclampsia continues to kill 76,000 mothers and 500,000 babies per year worldwide. It causes short and long term consequences such as future metabolic ...


Non-Directional Conjugation Of Fluorescent Antibodies To Gold Nanoparticles For Stem Cell Therapy, Kunal B. Shah 2016 University of Arkansas, Fayetteville

Non-Directional Conjugation Of Fluorescent Antibodies To Gold Nanoparticles For Stem Cell Therapy, Kunal B. Shah

Biomedical Engineering Undergraduate Honors Theses

The objective of this study was to design citrate-coated gold nanoparticles conjugated with FITC-IgG, a fluorescent antibody, and to qualitatively and quantitatively measure the resulting fluorescent emission. Optical properties of the gold nanoparticles were measured at various stages to provide evidence of successful conjugation. The absorbance spectrum of the citrate gold nanoparticles was compared to that of the reaction mixture containing the gold nanoparticles and the FITC-IgG. A noticeable broadening of the absorption peak was observed at 519 nm indicating a surface modification of the gold nanoparticles. Fluorescence data was obtained with a fluorospectrometer and revealed a significant amount of ...


Design Of Exercise Equipment For Wheelchair Users: A Case Study In Accessibility Standards, Kate Craddock Rescsanszky 2016 University of Connecticut

Design Of Exercise Equipment For Wheelchair Users: A Case Study In Accessibility Standards, Kate Craddock Rescsanszky

Honors Scholar Theses

Engineers must consider a number of aspects of every project they work on. Accessibility is one aspect that presents a unique challenge. Rather than being based on absolute material parameters, accessibility is based on how people interact with technology and their built environment. Since 1990, the Americans with Disabilities Act has been the predominant standard in accessibility because of its wide reach and legal mandate. In addition to the ADA, the ASTM and the Institute for Universal Design offer helpful guidelines for designing for accessibility. However, in addition to standards, guidelines, and recommendations, it is important to consult the intended ...


Crizotinib And Ceritinib Induce Apoptosis And Necrosis In Primary Rat Hepatocytes With Distinct Capacity, Alec T. Salminen 2016 University of Arkansas, Fayetteville

Crizotinib And Ceritinib Induce Apoptosis And Necrosis In Primary Rat Hepatocytes With Distinct Capacity, Alec T. Salminen

Biomedical Engineering Undergraduate Honors Theses

Drug development makes up a major portion of biomedical engineering research interests. The FDA oversees the introduction, experimentation, and implementation of all drugs before market approval is granted. Even after market approval is granted, the FDA continues to monitor the safety of all drugs. Crizotinib and ceritinib are two anaplastic lymphoma kinase (ALK) inhibitors recently approved by the FDA. Both drugs are indicated for treatment of non-small cell lung cancers (NSCLC) with abnormal ALK gene, and they are approved with a companion diagnostic test that determines ALK abnormality. Clinical trial data suggest that crizotinib and ceritinib can cause liver injury ...


Optimized Protocol For Measuring 2-Nbdg Uptake As A Cellular Marker Of Glycolytic Demand, Drew Folgmann 2016 University of Arkansas, Fayetteville

Optimized Protocol For Measuring 2-Nbdg Uptake As A Cellular Marker Of Glycolytic Demand, Drew Folgmann

Biomedical Engineering Undergraduate Honors Theses

2[N-(7-nitrobenz-2-oxa-1,2-diaxol-4-yl)amino]-2-deoxyglucose (2-NBDG) a fluorescently tagged analog of FDG is ideal for in vitro studies and imaging. 2-NBDG has been proven to be an adequate marker for glucose uptake in many different types of cells [1]. However, across the spectrum of 2-NBDG use a lack of consensus is observed for the following questions. What is the ideal time to fast cells to optimize cellular uptake of 2-NBDG? Also, what is the ideal concentration of 2-NBDG to be used when quantifying glucose uptake? Finally, what is the effect of serum on the uptake of 2-NBDG? To answer ...


Magnetism Of Magnetite Nanoparticles As Determined By Mössbauer Spectroscopy, Hien-Yoong Hah 2016 University of Tennessee - Knoxville

Magnetism Of Magnetite Nanoparticles As Determined By Mössbauer Spectroscopy, Hien-Yoong Hah

Masters Theses

Fe3O4 [Magnetite] nanoparticles have magnetism that differs greatly from their bulk counterparts. Whereas bulk Fe3O4 is a ferrimagnet, single-domain Fe3O4 nanoparticles have been found to be superparamagnetic. This allows for increased magnetization of the nanoparticles compared to the bulk when in a magnetic field. For most paramagnets, magnetization requires applied fields of a few Tesla at low temperatures. This is achievable through the application of superconducting magnets. In superparamagnets, the high susceptibility of the particles allows magnetization through a Nd-Fe-B permanent magnet at room temperature. This is caused by an increased ...


Circle Of Willis Model For Transcranial Doppler Ultrasound Training, Conner J. Beyersdorf, Ben Hage, Greg Bashford 2016 University of Nebraska-Lincoln

Circle Of Willis Model For Transcranial Doppler Ultrasound Training, Conner J. Beyersdorf, Ben Hage, Greg Bashford

UCARE Research Products

Transcranial Doppler (TCD) ultrasound is a technique involving the use of high frequency transmitters to measure intracranial blood flow. The brain is supplied by blood in an arterial anastomosis called the Circle of Willis. Using TCD ultrasound on the circle is difficult and requires practice and teaching. A functional model of the Circle of Willis could prove to be a valuable teaching tool. Through the use of AutoCAD and 3D printing software, an anatomically accurate model was created and set in gelatin phantom inside of a plastic skull. Milk was pumped through the model with a peristaltic pump to simulate ...


Analysis Of Breath-Holding Index As An Assessment Of Cerebrovascular Reactivity, Allison P. Porter, Madison Burger, Mohammed Alwatban, Benjamin Hage, Greg Bashford 2016 University of Nebraska - Lincoln

Analysis Of Breath-Holding Index As An Assessment Of Cerebrovascular Reactivity, Allison P. Porter, Madison Burger, Mohammed Alwatban, Benjamin Hage, Greg Bashford

UCARE Research Products

Cerebrovascular reactivity (CVR) is a key factor in regulating blood flow into the brain, and a marker for vascular disease. If the brain's regulatory system is not working, a patient may be in serious trouble. Testing of CVR is one method of assessing the brain's regulatory capabilities. Transcranial Doppler ultrasound (TCD) is one tool to measure CVR. In this method, carbon dioxide in the blood is transiently increased (such as with the holding of breath), and the resulting blood flow in the brain is measured. In this study, we are going to measure the variability of the breathholding ...


A Perturbation Based Decomposition Of Compound-Evoked Potentials For Characterization Of Nerve Fiber Size Distributions, Robert B. Szlavik 2016 California Polytechnic State University - San Luis Obispo

A Perturbation Based Decomposition Of Compound-Evoked Potentials For Characterization Of Nerve Fiber Size Distributions, Robert B. Szlavik

Robert Szlavik

The characterization of peripheral nerve fiber distributions,
in terms of diameter or velocity, is of clinical significance
because information associated with these distributions can be
utilized in the differential diagnosis of peripheral neuropathies.
Electro-diagnostic techniques can be applied to the investigation
of peripheral neuropathies and can yield valuable diagnostic
information while being minimally invasive. Nerve conduction
velocity studies are single parameter tests that yield no detailed
information regarding the characteristics of the population of
nerve fibers that contribute to the compound-evoked potential.
Decomposition of the compound-evoked potential, such that
the velocity or diameter distribution of the contributing nerve
fibers may ...


The Molecular And Mechanical Mechanisms Of The Age-Associated Increase In The Severity Of Experimental Ventilator Induced Lung Injury, Joseph Ames Herbert 2016 Virginia Commonwealth University

The Molecular And Mechanical Mechanisms Of The Age-Associated Increase In The Severity Of Experimental Ventilator Induced Lung Injury, Joseph Ames Herbert

Theses and Dissertations

Abstract

Background

The majority of patients requiring mechanical ventilation are over the age of 65 and advanced age is known to increase the severity of ventilator-induced lung injury (VILI) and mortality. However, the mechanisms which predispose aging ventilator patients to increased mortality rates are not fully understood.

Pulmonary edema is a hallmark of VILI and the severity of edema increases with age. Ventilation with conservative fluid management decreases mortality rates in acute respiratory distress (ARDS) patients, but has not been investigated in VILI. We hypothesized that age-associated increases in pulmonary edema promote age-related increases in ventilator-associated mortality. Endoplasmic reticulum (ER ...


Providing Support For An Interdisciplinary Research Group With A Multidisciplinary Informationist Team: Is It Effective?, Margaret Henderson, Karen Gau, Julie A. Arendt, Martha Roseberry, John Cyrus 2016 Virginia Commonwealth University

Providing Support For An Interdisciplinary Research Group With A Multidisciplinary Informationist Team: Is It Effective?, Margaret Henderson, Karen Gau, Julie A. Arendt, Martha Roseberry, John Cyrus

VCU Libraries Faculty and Staff Presentations

Background

Three subject librarians and a data librarian, representing three departments and two libraries at a university, were awarded an NLM Informationist Supplement to support an interdisciplinary Research Group with an NIH grant. The Informationist Team developed a model to utilize the skills of multiple librarians to support the increasing number of interdisciplinary and interprofessional research groups at the university. Librarians routinely attended lab meetings and shared notes with each other to monitor researcher needs.

Methods

The Informationist Team regularly provided support for literature searches, creating search alerts, bibliographic citation management and sharing, and data management to an interdisciplinary Research ...


The Effect Of Neurostimulation On Ischemic Pain And Methods Of Assessing Pain, Kaylee Keck 2015 California Polytechnic State University - San Luis Obispo

The Effect Of Neurostimulation On Ischemic Pain And Methods Of Assessing Pain, Kaylee Keck

Biomedical Eng/General Eng.

Peripheral arterial disease (PAD) impacts approximately eight million people in the United States [1]. Disease progression leads to chronic ischemic pain, hindering quality of life. Pharmaceuticals are a typical treatment for pain associated with PAD; but as few as 30% of patients have a significant reduction of pain (≥50%) [2].

Neurostimulation is commonly used as a treatment for various diseases and injuries, including Parkinson’s disease and sports-related back and knee injuries [2]. The objective of the study was to explore neurostimulation and its effect on pain and paresthesia for a model of acute peripheral ischemia in young college students ...


Cobalt Ferrite Nanoparticles Fabricated Via Co-Precipitation In Air: Overview Of Size Control And Magnetic Properties, Dennis Toledo 2015 Florida International University

Cobalt Ferrite Nanoparticles Fabricated Via Co-Precipitation In Air: Overview Of Size Control And Magnetic Properties, Dennis Toledo

FIU Electronic Theses and Dissertations

Cobalt Ferrite has important, size-dependent magnetic properties. Consequently, an overview of particle size is important. Co-precipitation in air was the fabrication method used because it is comparatively simple and safe. The effects of three different reaction times including 1, 2, 3 hour(s) on particle size were compared. Also, the effectiveness of three different capping agents (Oleic Acid, Polyvinylpyrollidone (PVP), and Trisodium Citrate) in reducing aggregation and correspondingly particle size were examined. Using Welch’s analysis of variance (ANOVA) and the relevant post hoc tests, there was no significant difference (p=0.05) between reaction times of 1 hour and ...


Biomechanical Investigation Of Elite Place-Kicking, Chase M. Pfeifer 2015 University of Nebraska-Lincoln

Biomechanical Investigation Of Elite Place-Kicking, Chase M. Pfeifer

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Many studies aim to understand the fundamentals of kicking commonly displayed by soccer players [4,6,10,16,17,18,24,25,28,29,30,34,36,38,40]. Of those studies, most are limited to a two-dimensional (2D) analysis using high-speed cameras for position tracking or utilizing electromyography to observe the activity of select muscles [4,6,18,25,29,36]. The few studies that investigate kicking using a three-dimensional (3D) model are limited in their position tracking capabilities and focus mainly on joint flexion potentials and foot speed.

This dissertation is a comprehensive biomechanical analysis (kinematic and EMG ...


Computational Characterization Of Exogenous Micrornas That Can Be Transferred Into Human Circulation, Jiang Shu, Kevin Chiang, Janos Zempleni, Juan Cui 2015 University of Nebraska-Lincoln

Computational Characterization Of Exogenous Micrornas That Can Be Transferred Into Human Circulation, Jiang Shu, Kevin Chiang, Janos Zempleni, Juan Cui

CSE Journal Articles

MicroRNAs have been long considered synthesized endogenously until very recent discoveries showing that human can absorb dietary microRNAs from animal and plant origins while the mechanism remains unknown. Compelling evidences of microRNAs from rice, milk, and honeysuckle transported to human blood and tissues have created a high volume of interests in the fundamental questions that which and how exogenous microRNAs can be transferred into human circulation and possibly exert functions in humans. Here we present an integrated genomics and computational analysis to study the potential deciding features of transportable microRNAs. Specifically, we analyzed all publicly available microRNAs, a total of ...


Mattrack: A Matlab-Based Quantitative Image Analysis Platform For Investigating Real-Time Photo-Converted Fluorescent Signals In Live Cells, Jane Courtney, Elena Woods, Virginie Gautier, William Hall, Dimitri Scholz 2015 Dublin Institute of Technology

Mattrack: A Matlab-Based Quantitative Image Analysis Platform For Investigating Real-Time Photo-Converted Fluorescent Signals In Live Cells, Jane Courtney, Elena Woods, Virginie Gautier, William Hall, Dimitri Scholz

Articles

We introduce here MATtrack, an open source MATLAB-based computational platform developed to process multi-Tiff files produced by a photo-conversion time lapse protocol for live cell fluorescent microscopy. MATtrack automatically performs a series of steps required for image processing, including extraction and import of numerical values from Multi-Tiff files, red/green image classification using gating parameters, noise filtering, background extraction, contrast stretching and temporal smoothing. MATtrack also integrates a series of algorithms for quantitative image analysis enabling the construction of mean and standard deviation images, clustering and classification of subcellular regions and injection point approximation. In addition, MATtrack features a simple ...


Concept Frequency Distribution In Biomedical Text Summarization, Lawrence Reeve, Hyoil Han, Saya Nagori, Jonathan Yang, Tamara Schwimmer, Ari Brooks 2015 Drexel University

Concept Frequency Distribution In Biomedical Text Summarization, Lawrence Reeve, Hyoil Han, Saya Nagori, Jonathan Yang, Tamara Schwimmer, Ari Brooks

Hyoil Han

Text summarization is a data reduction process. The use of text summarization enables users to reduce the amount of text that must be read while still assimilating the core information. The data reduction offered by text summarization is particularly useful in the biomedical domain, where physicians must continuously find clinical trial study information to incorporate into their patient treatment efforts. Such efforts are often hampered by the high-volume of publications. Our contribution is two-fold: 1) to propose the frequency of domain concepts as a method to identify important sentences within a full-text; and 2) propose a novel frequency distribution model ...


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