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Phototherapy Mounting System For Inpatient Rehabilitation, Kelsey Henderson, Elizabeth Fortunato, Jacob Dixon 2017 University of Tennessee, Knoxville

Phototherapy Mounting System For Inpatient Rehabilitation, Kelsey Henderson, Elizabeth Fortunato, Jacob Dixon

University of Tennessee Honors Thesis Projects

No abstract provided.


Design And Validation Of An In Vivo Long-Term Attachment Capsule Robot, Wanchuan Xie 2017 University of Nebraska-Lincoln

Design And Validation Of An In Vivo Long-Term Attachment Capsule Robot, Wanchuan Xie

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

The invention of capsule endoscopy (CE) made the non-invasive monitoring of the entire small bowel possible and became the primary means for diagnosing small bowel pathology. In the last decade, capsule robots have been transformed from diagnostic devices into a widely studied biomedical platform with the potential for active locomotion, drug delivery and therapeutic capabilities. To perform accurate on-site drug release and therapy, it is necessary for a capsule robot to be able to attach to the intestinal tissue and maintain its position long-term. Design challenges derive from the task of long-term mucosal adhesion which requires firm, quick-response attachment without ...


Characterization Of Murine Breast Cancer Cell Lines For Anti-Cancer Vaccine, Haven N. Frazier 2017 University of Arkansas, Fayetteville

Characterization Of Murine Breast Cancer Cell Lines For Anti-Cancer Vaccine, Haven N. Frazier

Biological Sciences Undergraduate Honors Theses

Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer death among women in the United States (1). While treatments involving radiation and chemotherapy currently exist, disease must be detected early in order for the treatments to be somewhat effective, and there is no effective treatment after metastasis occurs (2). Additionally, current therapies do not mitigate tumor immunosuppression. Decreasing the tumor-associated immunosuppressive conditions while activating antitumor immunity could prevent recurrence and metastasis, possibly leading to an effective treatment for cancer (3). Tumor cell vaccines could possibly address this issue and have become a ...


Chemical And Physical Priming Of Human Mesenchymal Stem Cells To Alter Nonviral Gene Delivery Outcomes, Tyler Kozisek, Andrew Hamann, Amy Mantz, Mathias Schubert, Eva Schubert, Angela K. Pannier 2017 University of Nebraska-Lincoln

Chemical And Physical Priming Of Human Mesenchymal Stem Cells To Alter Nonviral Gene Delivery Outcomes, Tyler Kozisek, Andrew Hamann, Amy Mantz, Mathias Schubert, Eva Schubert, Angela K. Pannier

Biological Systems Engineering--Dissertations, Theses, and Student Research

Human Mesenchymal Stem Cells: Human mesenchymal stem cells (hMSCs) are a multipotent cell, meaning they are able to differentiate into a more mature cell type, such as osteocytes, chondrocytes, and adipocytes, that are found in numerous tissues in the human body, such as bone marrow, fat, and muscle. Since hMSCs can be derived from adult human tissues, they do not have the same ethical concern associated with them as other stem cells, such as embryonic stem cells. Due to hMSCs multipotency and ease of obtaining, they have become one of the most widely researched stem cell types in areas such ...


A Novel Biochamberfor Modeling Of Atherosclerotic Arteries: In-Vitro Capabilities And Applications, Iman Salafian, Angelos Karagiannis, Benjamin S. Terry, Yiannis S. Chatzizisis 2017 University of Nebraska–Lincoln

A Novel Biochamberfor Modeling Of Atherosclerotic Arteries: In-Vitro Capabilities And Applications, Iman Salafian, Angelos Karagiannis, Benjamin S. Terry, Yiannis S. Chatzizisis

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Atherosclerosis is a chronic disease that involves the lipid accumulation and inflammation of the arterial wall [1,2]. Despite great efforts,its pathophysiology has not been fully elucidated. Existent drugs can reduce its progression but there are no available drugs to prevent its complications [3,4]. Atherosclerosis remains the leading global cause of death[5].

The purpose of this work is to design and build a customized biochamber which can be used for the following studies:

•Study the pathophysiology of atherosclerosis in vitro & ex vivo

•Investigate the mechanisms of atherosclerotic plaque disruption

•Examine the direct effect of different anti-atherosclerotic drugs ...


Acl Reconstruction Results In Alterations For Force Control Variability During Multidirectional Force Production, Amelia S. Lanier 2017 University of Nebraska at Omaha

Acl Reconstruction Results In Alterations For Force Control Variability During Multidirectional Force Production, Amelia S. Lanier

Student Research and Creative Activity Fair

After anterior cruciate ligament (ACL) rupture most will undergo reconstructive surgery. Within the first year after surgery 25% of patients will re-tear their ACL. Most of those injured attempt to return to sports which include running and cutting. The ability to produce appropriate ground reaction forces may be crucial for the successful return to sports without re-injury. Understanding stability of multidirectional ground reaction force (mGRF) production in healthy and ACL reconstructed (ACL-r) patients can lend insight to the high instance of re-injury. Typically, stability has been measured using linear analyses, but these analyses cannot capture the subtle time varying changes ...


Serum Comp And The Inflammatory Environment Of The Knee Before And After Exercise-Induced Load, Alyssa Evans, Robert D. Hyldahl, Sarah T. Ridge, Sunku Kwon, Ty J. Hopkins, Eric R. Robinson, Matthew K. Seeley 2017 Brigham Young University

Serum Comp And The Inflammatory Environment Of The Knee Before And After Exercise-Induced Load, Alyssa Evans, Robert D. Hyldahl, Sarah T. Ridge, Sunku Kwon, Ty J. Hopkins, Eric R. Robinson, Matthew K. Seeley

Biomedical Engineering Western Regional Conference

The purpose of this study was to determine how accurately serum COMP represents inflammatory cytokine levels, within the knee, before and after exercise.

Cytokines included: GM-CSF, IFNa2, IL-10, IL-12p40, IL-13, IL-15, IL-1ra, IL1b, IL1a, IL-4, IL-6, IL-8, IP-10, MCP-1, MIP-1a, MIP-1b and IL-17.


Super-Hydrophobic And Anti-Microbial Surfaces Via Carbon Infiltrated-Carbon Nanotubes, Christian DaLon Esplin, Anton Bowden, Brian Jensen 2017 Brigham Young University

Super-Hydrophobic And Anti-Microbial Surfaces Via Carbon Infiltrated-Carbon Nanotubes, Christian Dalon Esplin, Anton Bowden, Brian Jensen

Biomedical Engineering Western Regional Conference

No abstract provided.


A Nanocomposite Sensor Neck Sleeve For Tracking In Vivo Spine Kinematics In The Alpaca, Colton Porter Graham, Anton Bowden 2017 Brigham Young University

A Nanocomposite Sensor Neck Sleeve For Tracking In Vivo Spine Kinematics In The Alpaca, Colton Porter Graham, Anton Bowden

Biomedical Engineering Western Regional Conference

Chronic low back pain in the US is often attributed to intervertebral disc degeneration. Camelids, particularly alpacas, pose a potential model for spinal treatment due to similarity of the spinal structure and vertical loading. Alpacas also exhibit a high rate of natural disc degeneration. To gain more understanding about how disc degeneration is caused in alpacas it is necessary to understand the loading and motion of the alpaca cervical spine. The goal of the present work was to incorporate nanocomposite sensors into a custom-designed neck sleeve to track the daily in-vivo neck motion of an alpaca in its natural environment.


Separation Of Bacteria From Blood For Rapid Sepsis Diagnosis, Mahsa Alizadeh, Daniel Scott Mc Clellan, Colin Grant Bledsoe, Rae Blanco, Madison Melville, William G. Pitt 2017 Brigham Young University - Provo

Separation Of Bacteria From Blood For Rapid Sepsis Diagnosis, Mahsa Alizadeh, Daniel Scott Mc Clellan, Colin Grant Bledsoe, Rae Blanco, Madison Melville, William G. Pitt

Biomedical Engineering Western Regional Conference

No abstract provided.


Mri Field Mapping Using Bssfp Elliptical Signal Model, joseph valentine, Meredith Taylor, Steven Whitaker, Michael Hoff, Neal Bangerter 2017 Brigham Young University

Mri Field Mapping Using Bssfp Elliptical Signal Model, Joseph Valentine, Meredith Taylor, Steven Whitaker, Michael Hoff, Neal Bangerter

Biomedical Engineering Western Regional Conference

MRI, Field Mapping, bSSFP, ssfp, Elliptical Signal model, ellipse, phase unwrapping


Engineering Fret Biosensors For Microrna Presence/Absence Analysis, Nicholas E. Larkey, Sean M. Burrows 2017 Oregon State University

Engineering Fret Biosensors For Microrna Presence/Absence Analysis, Nicholas E. Larkey, Sean M. Burrows

Biomedical Engineering Western Regional Conference

No abstract provided.


Towards A Bioselective Surface For Treatment Of Sepsis In A Hemoperfusion Device, Karl F. Schilke, Ramya Raman, Bonan Yu, Erik Hahn, Jonathan Su 2017 Oregon State University

Towards A Bioselective Surface For Treatment Of Sepsis In A Hemoperfusion Device, Karl F. Schilke, Ramya Raman, Bonan Yu, Erik Hahn, Jonathan Su

Biomedical Engineering Western Regional Conference

Sepsis is a dysregulated immune response to circulating bacteria/endotoxin. Hemoperfusion is a promising treatment, but is not universally effective and can unacceptable blood damage. We are developing protein-repellent hydrogel nanofilms that can be grown on a variety of surfaces, and functionalized with “click-ready” pathogen-binding proteins expressed by Genetic Code Expansion (GCE). The extremely rapid, bioorthogonal “click” immobilization chemistry eliminates prior purification, maximizes surface loading, and guarantees spatial orientation of the immobilized proteins. We have demonstrated pathogen binding and blood protein repulsion by these layers, suggesting that they may be part of effective treatments for sepsis and other applications.


Histological Quantification In Temporal Lobe Epilepsy, Charlotte Anne Blinston 2017 The University of Western Ontario"

Histological Quantification In Temporal Lobe Epilepsy, Charlotte Anne Blinston

Electronic Thesis and Dissertation Repository

Approximately 30 percent of epilepsy patients suffer from refractory temporal lobe epilepsy which is commonly treated with resection of the epileptogenic tissue. However, surgical treatment presents many challenges in locating the epileptogenic focus and thus not all patients become seizure-free following surgery. Advances in techniques can lead to improved localization of the epileptogenic zone and may be validated by correlating MRI with neuropathology of the excised cortical tissue. Focal cortical dysplasias are a neuropathological group of cortical malformations that are often found in cases of refractory epilepsy, however, they are subtle and difficult to quantify. The purpose of this research ...


Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff 2016 University of Nebraska - Lincoln

Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff

Computer Science and Engineering: Theses, Dissertations, and Student Research

Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit them for novel purposes, such as the development of ubiquitous and heterogeneous communication networks to interconnect biological cells with nano and biotechnology-enabled devices, i.e., the Internet of Bio-Nano Things. One major problem in realizing these goals stands in the development of reliable techniques to control the engineered cells and their behavior from ...


Mechanism Of Interaction Of Peptide Modified Nanoparticles With Porphyromonas Gingivalis., Ankita Jain 2016 University of Louisville

Mechanism Of Interaction Of Peptide Modified Nanoparticles With Porphyromonas Gingivalis., Ankita Jain

Electronic Theses and Dissertations

Studies suggest that P. gingivalis functions as a keystone pathogen and interacts with primary colonizers in the supragingival biofilm such as S. gordonii. This interaction contributes to the initial colonization of the oral cavity by P. gingivalis and thus represents a potential target for therapeutic intervention. We have identified a peptide (BAR) derived from the streptococcal SspB protein that functions to inhibit P. gingivalis adherence to S. gordonii. In addition, we showed that nanoparticles (NPs) functionalized with BAR inhibit this interaction more potently than free soluble peptide, possibly by promoting interaction with P. gingivalis at higher valency than free peptide ...


A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox 2016 University of Maine

A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox

Electronic Theses and Dissertations

We explored the capabilities of additive manufacturing using a photo-cured jetted material 3D printer to manufacture a milli-microfluidic device with direct application in microalgae Dunaliella sp growth and intracellular compounds biosynthesis tests. A continuous microbioreactor for microalgae culture was CAD designed and successfully built in 1 hour and 49 minutes using black photopolymer cured by UV and a support material. The microreactor was made up of 2 parts including the bioreactor itself and a microchannel network for culture media fluids and microalgae. Both parts were assembled to form a single unit. Additional optical and auxiliar components were added. An external ...


The Impacts Of Arterial Occlusion, Sex, And Exercise On Arteriogenesis And Functional Vasodilation, Megan Tze-Mei Chu 2016 California Polytechnic State University, San Luis Obispo

The Impacts Of Arterial Occlusion, Sex, And Exercise On Arteriogenesis And Functional Vasodilation, Megan Tze-Mei Chu

Master's Theses and Project Reports

The most frequent clinical presentation of peripheral arterial occlusive disease (PAOD) is intermittent claudication, which may be caused by impaired vasodilation. Patients demonstrate both local and systemic impairments in vasodilation, but as the collateral circulation is the primary site of resistance to the ischemic zone, impaired collateral vasodilation would have the greatest potential to induce claudication. Collateral function following arterial occlusion is not well defined, but immature collaterals may demonstrate impaired vasodilation in animal models, although this is potentially improved with exercise training. Furthermore, as females exhibit poorer physical function with ischemia and less improvement with therapeutic exercise, there appears ...


Performance Factors In Neurosurgical Simulation And Augmented Reality Image Guidance, Ryan Armstrong 2016 The University of Western Ontario

Performance Factors In Neurosurgical Simulation And Augmented Reality Image Guidance, Ryan Armstrong

Electronic Thesis and Dissertation Repository

Virtual reality surgical simulators have seen widespread adoption in an effort to provide safe, cost-effective and realistic practice of surgical skills. However, the majority of these simulators focus on training low-level technical skills, providing only prototypical surgical cases. For many complex procedures, this approach is deficient in representing anatomical variations that present clinically, failing to challenge users’ higher-level cognitive skills important for navigation and targeting. Surgical simulators offer the means to not only simulate any case conceivable, but to test novel approaches and examine factors that influence performance. Unfortunately, there is a void in the literature surrounding these questions. This ...


Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson 2016 University of Tennessee - Knoxville

Analysis, Segmentation And Prediction Of Knee Cartilage Using Statistical Shape Models, Joseph Michael Johnson

Michael Johnson

Osteoarthritis (OA) of the knee is one of the leading causes of chronic disability (along with the hip). Due to rising healthcare costs associated with OA, it is important to fully understand the disease and how it progresses in the knee. One symptom of knee OA is the degeneration of cartilage in the articulating knee. The cartilage pad plays a major role in painting the biomechanical picture of the knee. This work attempts to quantify the cartilage thickness of healthy male and female knees using statistical shape models (SSMs) for a deep knee bend activity. Additionally, novel cartilage segmentation from ...


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