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Biomedical Engineering and Bioengineering Commons

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How Do Surgeon Preferences And Technique Variances Affect Outcome?, Anastasia Axiopoulou, Caroline G. L. Cao, Katherine Lin MD, Keith Watson MD 2020 Wright State University - Main Campus

How Do Surgeon Preferences And Technique Variances Affect Outcome?, Anastasia Axiopoulou, Caroline G. L. Cao, Katherine Lin Md, Keith Watson Md

Symposium of Student Research, Scholarship, and Creative Activities Materials

The goal of the research project is to create a blue-print of a robot-assisted hysterectomy procedure to support design and evaluation of technology to enhance system performance. To create this blue-print, we will conduct a task analysis, model the cognitive task flow and decision making, and develop a simulation of the hysterectomy procedure. The surgical simulation will be used as a platform to train surgeons on robotic-assisted hysterectomies, as well as to assess learning and performance. Additionally, it will be used to design and develop techniques and novel technology to support surgeons in their performance of the surgery. Current research ...


Indirect Structural Connectivity As A Biomarker For Stroke Motor Recovery, Miguel Renato Sotelo Munoz 2020 Marquette University

Indirect Structural Connectivity As A Biomarker For Stroke Motor Recovery, Miguel Renato Sotelo Munoz

Dissertations (2009 -)

In this dissertation project, we demonstrated that diffusion magnetic resonance imaging and measures of indirect structural brain connectivity are sensitive to changes in fiber integrity and connectivity to remote regions in the brain after stroke. Our results revealed new insights into the effects local lesions have on global connectivity—in particular, the cerebellum—and how these changes in connectivity and integrity relate to motor impairment. We tested this methodology on two stroke groups—subacute and chronic—and were able to show that indirect connectivity is sensitive to differences in connectivity during stroke recovery. Our work can inform clinical methods for ...


Mechanobiology Of Breast Cancer Cells, Shea Thompson 2020 University of Nebraska-Lincoln

Mechanobiology Of Breast Cancer Cells, Shea Thompson

UCARE Research Products

Mechanobiology Cells response to mechanical loading Mechanical loading includes Shear flow, Stretching, Compression

How does shear flow effect breast cancer cell migration in a three dimensional space?

By going through the engineering cycle, I was able to successfully convert the Parallel Flow Chamber into a Three Dimensional Flow Chamber. At this point, I have no results due to the COVID-19 outbreak.

Future Research Understanding how breast cancer migrates is essential to preventing the spread of cancer. While other chemical means have been investigated, mechanotransduction is relatively unexplored. Next step: Mechanobiology of breast cancer cells moving through a maze Cells have ...


“Gobabygo!” – Rehab Engineering To Make Children Mobile, Connor Albin, Chase M Pfeifer 2020 University of Nebraska - Lincoln

“Gobabygo!” – Rehab Engineering To Make Children Mobile, Connor Albin, Chase M Pfeifer

UCARE Research Products

GoBabyGo! is a project to give children with movement difficulties a chance to move on their own. GoBabyGo! conducts community builds of modified ride-on-cars for these children and grants them mobility. Once issue is that once children have cars, there is no feedback to improve future builds. This project "“GoBabyGo!” – Rehab Engineering to Make Children Mobile," wishes to collect quantifiable data on how these cars are being used and how they can be improved. This project aims to do this by collecting surveys from caretakers and through a programmed module to be installed in cars. The installed car module collects ...


Nanoparticle Treatment To Counter Reactive Oxygen Species After Traumatic Brain Injury, Brandon McDonald, Forrest Kievit 2020 University of Nebraska - Lincoln

Nanoparticle Treatment To Counter Reactive Oxygen Species After Traumatic Brain Injury, Brandon Mcdonald, Forrest Kievit

UCARE Research Products

Traumatic brain injury (TBI) is defined as damage to the brain, resulting from an external mechanical force, such as an impact to the head (Kievit et. al, 2016).There are several examples that could result in a potential TBI; such as falling with contact to the head, car accidents and even physical activities including football, wrestling, and boxing. Because of the several different scenarios that an individual could impact their head, TBI’s have become an all too common aspect of everyday life. TBI is currently the leading cause of death and disability in children and adults under the age ...


Design Of An Affordable Rotating Drum Electrospinner For Classroom Education, Peder Solberg 2020 South Dakota State University

Design Of An Affordable Rotating Drum Electrospinner For Classroom Education, Peder Solberg

The Journal of Undergraduate Research

Electrospinning is a technology used to generate small fibers down to nano-scale size. This method of fiber creation has been around for many years. However, in recent years electrospinning has found increased applications, especially in the area of tissue engineering due to its ability to create fibers with properties similar to the extracellular matrix in tissue. An electrospinning platform can illustrate concepts of engineering, electro-mechanical system design, manufacturing, and biomedical applications in one single package. Hence, it provides an excellent opportunity to integrate into secondary (middle and high school) and post-secondary (undergraduate) technology education.

Furthermore, just as integration of 3D ...


Machine Learning Towards General Medical Image Segmentation, Clara Tam 2020 The University of Western Ontario

Machine Learning Towards General Medical Image Segmentation, Clara Tam

Electronic Thesis and Dissertation Repository

The quality of patient care associated with diagnostic radiology is proportionate to a physician's workload. Segmentation is a fundamental limiting precursor to diagnostic and therapeutic procedures. Advances in machine learning aims to increase diagnostic efficiency to replace single applications with generalized algorithms. We approached segmentation as a multitask shape regression problem, simultaneously predicting coordinates on an object's contour while jointly capturing global shape information. Shape regression models inherent point correlations to recover ambiguous boundaries not supported by clear edges and region homogeneity. Its capabilities was investigated using multi-output support vector regression (MSVR) on head and neck (HaN) CT ...


Cuffless Single-Site Photoplethysmography For Blood Pressure Monitoring, Manish Hosanee, Richard Fletcher, Mohamed Elgendi 2020 University of British Columbia

Cuffless Single-Site Photoplethysmography For Blood Pressure Monitoring, Manish Hosanee, Richard Fletcher, Mohamed Elgendi

Open Access Articles

One in three adults worldwide has hypertension, which is associated with significant morbidity and mortality. Consequently, there is a global demand for continuous and non-invasive blood pressure (BP) measurements that are convenient, easy to use, and more accurate than the currently available methods for detecting hypertension. This could easily be achieved through the integration of single-site photoplethysmography (PPG) readings into wearable devices, although improved reliability and an understanding of BP estimation accuracy are essential. This review paper focuses on understanding the features of PPG associated with BP and examines the development of this technology over the 2010-2019 period in terms ...


Effects Of Novel Tool Use: Cortical And Functional Measures In Children Using A Prosthetic Simulator, Chris Copeland 2020 University of Nebraska at Omaha

Effects Of Novel Tool Use: Cortical And Functional Measures In Children Using A Prosthetic Simulator, Chris Copeland

Student Research and Creative Activity Fair

As of 2005, there were a total of 1.6 million people living with the loss of a limb, with this population projected to double to 3.6 million by 2050 [1]. While prostheses aim to enhance the function of these individuals, it is estimated that 45% of pediatric prosthetic users reject their prosthesis [2]. The literature which describes the neurological control mechanisms of prosthetic use is sparse and often low-powered due to an inadequate number of participants. However, prosthetic simulators may be a solution to chronically low-powered prosthetic-centric studies by serving as functional homologues, though this has yet to ...


Autocorrelation And Probability Distributions In Gait-Metronome Synchronization, Charles Sloan 2020 University of Nebraska at Omaha

Autocorrelation And Probability Distributions In Gait-Metronome Synchronization, Charles Sloan

Student Research and Creative Activity Fair

Recent research has shown that the structure of different pacing signals influences gait dynamics during coordination to those signals. Those studies, however, have not looked at the impact that probability distribution functions play in influencing our gait. This study looks at how both autocorrelation functions and probability distribution has in noisy metronomes to look for sources of synchronization. 10 healthy subjects volunteered to complete this study. The participants were required to wear custom-built glasses with a small screen projected on the lens. The screen showed a visual stimulus that correlated with various signals. The results of the study suggest that ...


On-Body Pressure For Subcutaneous Infusion Of Drug, Hannah Cole, Kayla Meacham, Eleanor Moran, Kaylee Voss 2020 California Polytechnic State University, San Luis Obispo

On-Body Pressure For Subcutaneous Infusion Of Drug, Hannah Cole, Kayla Meacham, Eleanor Moran, Kaylee Voss

Biomedical Engineering

No abstract provided.


Ikioo Flying Robot, Nicholas Michael Lapidus, Bosung Josh Kim, Jenny Fong 2020 California Polytechnic State University, San Luis Obispo

Ikioo Flying Robot, Nicholas Michael Lapidus, Bosung Josh Kim, Jenny Fong

Biomedical Engineering

No abstract provided.


Cumulative Shear In Vitro Model, Jared Olson, Alex Deppe, Braden Andrews 2020 California Polytechnic State University, San Luis Obispo

Cumulative Shear In Vitro Model, Jared Olson, Alex Deppe, Braden Andrews

Biomedical Engineering

The purpose of our project is to find a reliable method of Subclinical Atherosclerosis detection by measuring the pressure drop across an artery. This model is intended to display how a pressure change correlates with arterial shear rate, and how a decrease in shear rate is ultimately related to atherosclerosis wherein early detection could prove life saving for millions of patients worldwide.


Gesea Biosciences - Core Shell Pellet Manufacturing Device, Claire Edelman, Maria Medrano, Rachel Longoria 2020 California Polytechnic State University, San Luis Obispo

Gesea Biosciences - Core Shell Pellet Manufacturing Device, Claire Edelman, Maria Medrano, Rachel Longoria

Biomedical Engineering

No abstract provided.


Integrity Testing Of Gas Permeable Silicone Filters, Maggie M. Baker, Thomas P. Humann, Kevin J. Yerina 2020 California Polytechnic State University, San Luis Obispo

Integrity Testing Of Gas Permeable Silicone Filters, Maggie M. Baker, Thomas P. Humann, Kevin J. Yerina

Biomedical Engineering

This report investigates the most reasonable, cost efficient, and reliable ways to integrity test a filter made from a permeable silicone membrane for future biomedical and pharmaceutical applications. The goal of the project was to create a fixture that a pharmaceutical company can use to quickly and reliably test the integrity of the filter. A variety of methods are outlined to test the integrity of the filter, after a series of quantitative tests, a single method was established that meet the requirements most thoroughly. The method that was determined to be most effective involves a series of components including a ...


Esophageal Temperature Mapping And Monitoring Sheath, Nicole M. Rogers, Hillary Johnson, Alexander Silva 2020 California Polytechnic State University, San Luis Obispo

Esophageal Temperature Mapping And Monitoring Sheath, Nicole M. Rogers, Hillary Johnson, Alexander Silva

Biomedical Engineering

The purpose of this document is to provide a product development summary for an accessory device that joins an esophageal temperature probe and a mapping catheter together to be used during cardiac ablation. Catheter ablation therapy is performed in the left atrium, utilizing extremely hot or cold temperatures to create scar tissue and treat atrial fibrillation and other arrhythmias. The close positioning of the left atria adjacent to the esophagus presents a large risk as the extreme temperatures used during ablation can lead to esophageal damage or fistulas. This device is designed to integrate correlate data from the temperature probe ...


Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso 2020 California Polytechnic State University, San Luis Obispo

Solostand, Hau Nhat Doan, Sydney Gray, Celina Dioso

Biomedical Engineering

The purpose of this scope of work is to highlight the progress and development of SoloStand sponsored by Derek Herrera, chief technical officer and founder of SpinalSingularity. SoloStand is an attachment to a wheelchair that will benefit paraplegics that use wheelchairs. A portable and customizable attachment to a wheelchair will allow the user to do everyday tasks without transferring into a separate standing wheelchair and travel more easily. This document outlines everything that has been done in fulfillment of our senior project requirements.


Prosthetic Thumb, Allison M. Sigdestad, Sahil Sharma, Cale Foreman 2020 California Polytechnic State University, San Luis Obispo

Prosthetic Thumb, Allison M. Sigdestad, Sahil Sharma, Cale Foreman

Biomedical Engineering

The Prosthetic Thumb Project is a senior design project completed by Biomedical Engineering Undergraduate students at California Polytechnic State University. This senior design project is aimed at designing a prosthetic thumb for a Cal Poly Pomona student who lost their thumb in an accident last year. The patient has ultimately lost between 30-40% of functionality of his left hand, and so we would like to give him that mobility back. Originally, the patient was worried about having a prosthesis, and wanted something more stagnant that would resemble the look of the thumb he lost. However, after working with him, we ...


Left Atrial Appendage Printing Process, Areli Reyes, Brandon James Mukai, Mia Noelle von Knorring 2020 California Polytechnic State University, San Luis Obispo

Left Atrial Appendage Printing Process, Areli Reyes, Brandon James Mukai, Mia Noelle Von Knorring

Biomedical Engineering

The left atrial appendage senior design team aims to assist in closing off the left atrial appendage that is susceptible to coagulation due to non-valvular atrial fibrillation. Coagulation in the left atrial appendage (LAA) can be life threatening as it can lead to a stroke. Dr. Chris Porterfield performs a procedure that uses the Boston Scientific Watchman to close the appendage. He finds that sizing the Watchman properly is difficult with limited visuals from live CT scans. He proposed converting the CT scans into a 3D printed model of the left atrial appendage and left atrium so he can visually ...


Pulmonary Imaging Of Chronic Obstructive Pulmonary Disease Using Multi-Parametric Response Maps, Jonathan MacNeil 2020 The University of Western Ontario

Pulmonary Imaging Of Chronic Obstructive Pulmonary Disease Using Multi-Parametric Response Maps, Jonathan Macneil

Electronic Thesis and Dissertation Repository

Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction caused by airway remodelling and parenchymal destruction. Clinically, observation of COPD is performed using spirometry, but this technique only provides a global measure of lung health. To supplement these clinical measurements, thoracic computed tomography (CT) and hyperpolarized gas magnetic resonance imaging (MRI) have been used to measure regional structure and function abnormalities. Although CT and MRI have been used to research COPD, combination of both modalities into an interrelated image has never been performed. Therefore, we developed an image processing pipeline to combine MRI-CT information into a multi-parametric response ...


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