Family, Life Course, and Society Commons^™

Rheumatoid Arthritis-Associated Polymorphisms Are Not Protective Against Alzheimer's Disease, Christopher R. Simmons, Fanggeng Zou, Steven G Younkin, Steven Estus

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Rheumatoid arthritis (RA) and Alzheimer's disease (AD) are inversely associated. To test the hypothesis that genetic elements associated with increased RA risk are associated with decreased AD risk, we evaluated RA genetic risk factors recently identified in genome-wide association studies (GWAS) for their association with AD in a two-stage, case-control analysis.

RESULTS: In our Stage 1 analysis of ~800 AD and ~1,200 non-AD individuals, three of seventeen RA-associated SNPs were nominally associated with AD (p < 0.05) with one SNP, rs2837960, retaining significance after correction for multiple testing (p = 0.03). The rs2837960_G (minor) allele, which is associated with increased RA risk, was associated with increased AD risk. Analysis of these three SNPs in a Stage 2 population, consisting of ~1,100 AD and ~2,600 non-AD individuals, did not confirm their association with AD. Analysis of Stage 1 and 2 combined suggested that rs2837960 shows a trend for association with AD. When the Stage 2 population was age-matched for the Stage 1 population, rs2837960 exhibited a non-significant trend with AD. Combined analysis of Stage 1 and the age-matched Stage 2 subset showed a significant association of rs2837960 with AD (p = 0.002, OR 1.24) that retained significance following correction for age, sex and APOE (p = 0.02, OR = 1.20). Rs2837960 is near BACE2, which encodes an aspartic protease capable of processing the AD-associated amyloid precursor protein. Testing for an association between rs2837960 and the expression of BACE2 isoforms in human brain, we observed a trend between rs2837960 and the total expression of BACE2 and the expression of a BACE2 transcript lacking exon 7 (p = 0.07 and 0.10, respectively).

CONCLUSIONS: RA-associated SNPs are generally not associated with AD. Moreover, rs2837960_G is associated with increased risk of both RA and, in individuals less than …

The Influence Of Profession And Therapy Type For The Cost Effective Treatment Of Sexual Dysfunction, David Fawcett

Theses and Dissertations

Sexual dysfunctions are serious mental health issues that impact an estimated one in three Americans. Due to the complex, relational nature of most sexual dysfunctions, mental health professionals trained to work with couples and their relationship interactions are likely to have better outcomes when treating clients with sexual dysfunction. Data from CIGNA Health Solutions was analyzed to explore differences in therapy outcome for various types of mental health professions when treating clients with sexual dysfunctions. The current research is a retrospective analysis of administrative data that explores whether or not type of profession (i.e. psychologists, Masters of social work, marriage …

Analyzing Sexual Expression: Marriage, Prostitution, And The Law, Leah Christiani

Honors Scholar Theses

Marriage and prostitution laws solidify and propagate norms about sexual expression. Marriage law functions positively to dictate the kind of expression that is acceptable, normal, and natural while prostitution law frames the illegal, deviant, and unnatural. The legal benefits offered to those who marry function as an endorsement of a particular type of sexual expression: monogamous, faithful, loving, long term, and procreative. Equally, the criminalization of prostitution solidifies norms about the wrong, illegal unnatural kind of sexual expression; one focused on pleasure and money, not monogamy, fidelity, love, or procreation. These valuations of sexual expression solidified by the law impact …

The Politics Of Health Outcomes And Income Inequality: A Time Series Cross-Sectional Analysis Of County-Level Mortality Rates In The United States, Timothy H. Callaghan

Honors Scholar Theses

: Health inequalities are pervasive in the United States today. Despite social epidemiologists frequently citing political and economic factors for this variance, political science has largely ignored these issues. Given this gap in the literature and the importance of the issue, more research is clearly needed to better understand the political and economic causes and implications of these health disparities. This study analyzes the topic in depth, examining how income inequality, which is believed to be a key factor in explaining health inequalities, is related to mortality rates at the county level. Examining aggregate data from all US counties from …

Residents' Perceptions Of Social Interaction And Social Activity In An Affordable Assisted Living Facility, Elena Garcia

Honors Scholar Theses

This study is a qualitative study looking at the social interactions and social activities in an assisted living facility, based on the residents’ perceptions. In this study I interviewed 20 residents of an affordable assisted living facility. The participants were male and female, 65 or older, and any ethnicity. Inclusion criteria include: (1) Residing in the assisted living facility at least 6 months and no more than 2 years; and (2) being mentally competent to give informed consent. I recruited the participants based on a list of who was eligible from the facilities administration and then asked the eligible participants …

The Effects Of Domestic Violence: The Male Victims Perspective., Ramon B. Younger

Electronic Theses and Dissertations

Domestic violence from a male victim's perspective is something that is not discussed in society very much because information is very limited and incidents are often unreported. Research was done on this aspect of domestic violence to see how the types of abuse have had an impact on the victim from a physical and emotional perspective. The secondary data used for this study were from the Violence and Threats of Violence Against Women and Men in the United States, 1994-1996. Eight thousand men were selected to participate in the survey. The question of whether domestic violence is a problem was …

A Funny Thing About Marriage, Genevia R. Slate

Graduate Theses

The purpose of the present study was to examine the relationship between marital satisfaction and the use of humor, and to investigate whether or not this relationship was influenced by the length of marriage. I also examined how humor was appreciated as the couples were married longer and who produced the most humor; the husband or the wife. It was hypothesized that marital satisfaction would be highest among married couples who use higher levels of humor, that couples who had been married longer would have a greater appreciation of humor, and that the male partner would produce the most humor …

Poverty In Massachusetts For Families With Children, Randy Albelda, Ferry Cadet, Dinghong Mei

Center for Social Policy Publications

Massachusetts has lower poverty rates compared to the US average for all families with children. The poverty rates for female-headed families with children (single mother families) are 5.5 times higher than those of married couples with children in Massachusetts and the US.

Poverty rates for families with children differ considerably across Massachusetts’ ten largest cities, and are typically considerably higher than the Massachusetts average for all family types. Springfield has the highest poverty rates for each family type with children while Quincy has the lowest.

The Experience Of Counseling The Terminally Ill And The Best Counseling Practices, Helen Jackson Bleicher

Student Work

As people approach the end of their lives, many experience anxiety throughout the dying experience. This research investigated the death experience of terminally ill patients and the best counseling practices among licensed mental health practitioners. The questions developed by the researcher served as the measure, which was developed specifically for this research. The questions were given to a small purposive sample of counselors (N=10) who work in hospice settings, private practice, and oncology clinics. This research found that counselors focus on the psychosocial and spiritual aspects of dying, and observe patients having less death anxiety when they are comfortable with …

The Process Of Becoming A Strong Glbt Family: A Grounded Theory, Maureen E. Todd

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Using the qualitative method of grounded theory, data were collected from 21 couples who identified as Gay, Lesbian, Bisexual, and/or Transgender (GLBT) from across the country. The purpose of this grounded theory was to generate a model that explains the process of developing family strengths in GLBT couples. In-depth interviews (both in person and phone interviews), observations with field notes, and member checking were used. A theoretical model was developed describing 1) the central phenomenon of strong GLBT families, 2) the contexts in which GLBT families thrive, 3) the various strategies GLBT couples use to build and maintain their strengths, …

Emotion Work On The Home-Front: The Special Case Of Military Wives, Kimberly Michelle Murray

Graduate Theses and Dissertations

This research includes interviews with twelve military wives to examine emotion-work techniques used to negotiate the everyday life of wives during their husbands' deployment. In this study, I seek to better understand the ways in which military wives negotiate their feelings within a context of military masculinity and how they manage role strain, feelings of loneliness, isolation, and marginalization. In addition, I examine the cultural constructs available to wives, such as traditional gender roles and subordination. Interviews confirm the complexity of the life of the military wife, revealing challenges of contradictory emotions in relationship to the military, her husband, her …

Housing Factors Associated With Marital Satisfaction, Samantha J. Nelson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to assess the direction and magnitude of the relationship between levels of marital satisfaction and two main housing variables--the housing burden ratio and the amount of home equity. The influence that these variables have on levels of marital satisfaction was mediated and moderated by how satisfied couples were with their homes and their finances, as well as their perceived experience of economic pressure. The results ultimately provide insights that can improve both couple well-being and financial/housing situations by pinpointing factors that account for the variance in marital satisfaction.

This study used existing data from …

An Examination Of The Grieving Processes Of Suicide Survivors, Sarah Van Der Pol

UNLV Theses, Dissertations, Professional Papers, and Capstones

The scope of this research serves to aid in the understanding and counseling of survivors of loved ones who have committed suicide. This study will examine the phenomenon of survivors; specifically, what occurs as survivors move through the experience of grief and loss, as well as their individual grieving processes. The grieving process of those who deal with suicidal deaths of loved ones will be examined. Themes that emerge within the experiences of the participants will be identified and examined. Further, recommendations for the clinical practice of current and future counselors for work with suicide survivors will be suggested. Recommendations …

Examining Activity Levels And Motor Proficiency: A Comparison Of Children Who Are Overweight And At A Healthy Weight To Their Parents And Peers, Aaron Copeland, Maresa Madsen, Riley Phelps, Brandon Richards

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective: The purpose of this study was to examine relationships and differences between motor proficiency, activity level, and parental activity level in children who are at a healthy weight and children who are overweight or obese.

Methods: Forty-four children (26 children at a healthy weight and 18 children who were overweight or obese) between the ages of 8-16 (BMI: 14.3-43.6 kg/m2) and 36 parents (BMI: 18.1-44.7) participated in this study. Children and parents wore StepWatch activity monitors (SAM) to measure activity levels over a 72 hour period. Tests reflecting several determinants of motor performance were also administered to …

Clark Memorandum: Spring 2011, J. Reuben Clark Law Society, Byu Law School Alumni Association, J. Reuben Clark Law School

The Clark Memorandum

• Law and Becoming (Elder D. Todd Christofferson)
• Ambiguity in Law and in Life (Elder Bruce C. Hafen)
• "Serve God, Love Me, and Mend" (Annette W. Jarvis)
• Do U.S. Courts Discriminate Against Treaties? (David H. Moore)

Toward A Conceptual Model Linking Community Violence Exposure To Hiv-Related Risk Behaviors Among Adolescents: Directions For Research, Dexter R. Voisin

Faculty Scholarship

Purpose: To present a conceptual framework which accounts for the relationship between community violence exposures (CVEs) and youth HIV risk behaviors. Methods: This article provides an overview of existing research on the links between CVE and HIV risk for youth and offers a conceptual framework for clarifying how CVE might contribute to HIV sexual risk behaviors. Results: Increasing empirical findings substantiate that the links between CVE and HIV risk behaviors among youth are mediated by psychological problem behaviors, low school success rates, and negative peer influences. Conclusions: Researchers have identified the behaviors that place teens at risk for becoming infected …

An Assessment Of Child Welfare: The Value Of Training And Family Engagement, Kelly L. Scherado

Graduate Research Symposium (2010 - 2017)

Child maltreatment in the United States continues to be one of the nation’s most serious social problems. Child welfare practice is intended to ensure the safety, permanency, and well-being of children and families. One of the ways child welfare systems can achieve positive outcomes for vulnerable children is to utilize the most current best practices in training, focused on family engagement and strengths-based empowerment. To this end, child welfare training programs that are family centered, culturally competent, and focused on preventing out of home placements, should be implemented nationwide to better prepare child welfare agencies to meet the needs of …

Infertility Help Seeking And Social Support: Do Conventional Theories Explain Internet Behaviors And Outcomes, Kathleen S. Slauson-Blevins

Department of Sociology: Dissertations, Theses, and Student Research

This dissertation uses data from the National Survey of Fertility Barriers (NSFB), a nationally representative sample, to assess factors associated with face-to-face and internet help seeking (study 1) and perceived social support (study 2).  In study one, I examine whether the General Help Seeking Model, a theory that has been used to explain in-person help seeking, generalizes to internet help seeking. I assess four types of help seeking:  (1) no help seeking, (2) only internet help seeking, (3)only medical help seeking, and (4) both online and medical help seeking.  Results suggest that online help seeking is differentiated from in person …

Antecedents Of Parental Psychological Control: A Test Of Bowen's Theory, Spencer D. Bradshaw

Theses and Dissertations

Parental psychological control has been found to be associated with both internalized and externalized problems for youth and adolescents. Research contributing to an understanding of the possible antecedents of parental psychological control is both limited and of need; specifically regarding parents' psychological attributes. This study sample included 323 two-parent families and an identified target child from each family. Bowen's theory of family systems, [chronic] stress, and differentiation of self and its relation to parental psychological control was examined. Differentiation of self was hypothesized to mediate the relationship between chronic stress and parental psychological control. Differentiation was conceptualized and measured using …

Personality And Relationship Satisfaction: Evaluating The Direct Associations Between Neuroticism, Agreeableness, Extraversion, And Relationship Satisfaction In Romantic Couple Relationships, Sarah Lefevre Tackett

Theses and Dissertations

Specifically, using a sample of 2,848 couples from the RELATE dataset, a model was tested examining the direct associations between personality factors (neuroticism, agreeableness, and extraversion) and relationship satisfaction in romantic couple relationships. The results indicated that lower levels of neuroticism, higher levels of agreeableness, and lower levels of extraversion were associated with greater relationship satisfaction. In particular, ratings of agreeableness had the strongest associations with satisfaction for males and females, while neuroticism had the next strongest associations, followed by extraversion. Paths between male variables and female variables and satisfaction were not significantly different; however, slight gender differences were present …