Family, Life Course, and Society Commons^™

Immunomodulators As Therapeutic Agents In Mitigating The Progression Of Parkinson's Disease, Bethany Grimmig, Josh Morganti, Kevin Nash, Paula C. Bickford

Sanders-Brown Center on Aging Faculty Publications

Parkinson’s disease (PD) is a common neurodegenerative disorder that primarily afflicts the elderly. It is characterized by motor dysfunction due to extensive neuron loss in the substantia nigra pars compacta. There are multiple biological processes that are negatively impacted during the pathogenesis of PD, and are implicated in the cell death in this region. Neuroinflammation is evidently involved in PD pathology and mitigating the inflammatory cascade has been a therapeutic strategy. Age is the number one risk factor for PD and thus needs to be considered in the context of disease pathology. Here, we discuss the role of neuroinflammation within …

Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic And Ca2+-Handling Deficits In Alzheimer's Disease Models, Erez Eitan, Emmette R. Hutchison, Krisztina Marosi, James Comotto, Maja Mustapic, Saket M. Nigam, Caitlin Suire, Chinmoyee Maharana, Gregory A. Jicha, Dong Liu, Vasiliki Machairaki, Kenneth W. Witwer, Dimitrios Kapogiannis, Mark P. Mattson

Sanders-Brown Center on Aging Faculty Publications

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder in which aggregation-prone neurotoxic amyloid β-peptide (Aβ) accumulates in the brain. Extracellular vesicles (EVs), including exosomes, are small 50–150 nm membrane vesicles that have recently been implicated in the prion-like spread of self-aggregating proteins. Here we report that EVs isolated from AD patient cerebrospinal fluid and plasma, from the plasma of two AD mouse models, and from the medium of neural cells expressing familial AD presenilin 1 mutations, destabilize neuronal Ca²⁺ homeostasis, impair mitochondrial function, and sensitize neurons to excitotoxicity. EVs contain a relatively low amount of Aβ but have an …

Reduced Efficacy Of Anti-AΒ Immunotherapy In A Mouse Model Of Amyloid Deposition And Vascular Cognitive Impairment Comorbidity, Erica M. Weekman, Tiffany L. Sudduth, Carly N. Caverly, Timothy J. Kopper, Oliver W. Phillips, David K. Powell, Donna M. Wilcock

Sanders-Brown Center on Aging Faculty Publications

Vascular cognitive impairment and dementia (VCID) is the second most common form of dementia behind Alzheimer's disease (AD). It is estimated that 40% of AD patients also have some form of VCID. One promising therapeutic for AD is anti-Aβ immunotherapy, which uses antibodies against Aβ to clear it from the brain. While successful in clearing Aβ and improving cognition in mice, anti-Aβ immunotherapy failed to reach primary cognitive outcomes in several different clinical trials. We hypothesized that one potential reason the anti-Aβ immunotherapy clinical trials were unsuccessful was due to this high percentage of VCID …

The Only Way I Was Going To 'Veganize' My Life Was To Immerse Myself, Amanda Osorio

UCF Forum

This summer I made the decision to do something that many Latins often hesitate to attempt: become a vegan.

Prospective And Dyadic Associations Between Expectant Parents’ Prenatal Hormone Changes And Postpartum Parenting Outcomes, Robin S. Edelstein, William J. Chopik, Darby E. Saxbe, Britney M. Wardecker, Amy C. Moors, Onawa P. Labelle

Psychology Faculty Articles and Research

During the transition to parenthood, both men and women experience hormone changes that are thought to promote parental care. Yet very few studies have explicitly tested the hypothesis that prenatal hormone changes are associated with postpartum parenting behavior. In a longitudinal study of 27 first-time expectant couples, we assessed whether prenatal hormone changes predicted self and partner-reported parenting outcomes at three months postpartum. Expectant fathers showed prenatal declines in testosterone and estradiol, and larger declines in these hormones predicted larger contributions to household and infant care tasks postpartum. Women whose partners showed larger testosterone declines also reported receiving more support …

Bringing Mothers And Fathers Together: Undergraduate Studies In Anthropology And Sociology, Angela Castañeda, Matthew Oware

Sociology and Anthropology Faculty Publications

As social scientists in a combined Sociology and Anthropology department at a small liberal arts institution, we approach research questions on mothering and fathering from our respective disciplines. In the summer of 2014 we made plans to experiment with a first year seminar that would bring our distinct courses together: Oware’s Man Up: Unpacking Manhood and Masculinity, and Castañeda’s Global Perspectives on Reproduction and Childbirth. In the fall of 2014, we combined our courses over two-weeks to discuss the roles of fathering and mothering in our research agendas. As we suspected, our courses were unevenly represented on their own with …

Network Approaches To Substance Use And Hiv/Hepatitis C Risk Among Homeless Youth And Adult Women In The United States: A Review, Kirk Dombrowski, Kelley J. Sittner, Devan Crawford, Melissa L. Welch-Lazoritz, Patrick Habecker, Bilal Khan

Department of Sociology: Faculty Publications

During the United States economic recession of 2008–2011, the number of homeless and unstably housed people in the United States increased considerably. Homeless adult women and unaccompanied homeless youth make up the most marginal segments of this population. Because homeless individuals are a hard to reach population, research into these marginal groups has traditionally been a challenge for researchers interested in substance abuse and mental health. Network analysis techniques and research strategies offer means for dealing with traditional challenges such as missing sampling frames, variation in definitions of homelessness and study inclusion criteria, and enumeration/population estimation procedures. This review focuses …

L'Effet De La Sélection De L’Immigrant En Bonne Santé Au Canada: Une Revue Systématique, Zoua Vang, Jennifer Sigouin, Astrid Flenon, Alain Gagnon

Population Change and Lifecourse Strategic Knowledge Cluster Discussion Paper Series/ Un Réseau stratégique de connaissances Changements de population et parcours de vie Document de travail

Au Canada, la politique d'immigration favorise les individus ayant un capital humain élevé (Knowles, 2007). Étant donné les liens étroits entre le capital humain et la santé (Jasso et al., 2004) et le fait que les recherches suggèrent la présence d'un avantage de santé universel au sein de la population immigrante au Canada, nous nous attendions à observer l'effet de la sélection de l’immigrant en bonne santé à tous les stades du parcours de vie et sur des problèmes de santé multiples. Notre examen suggère plutôt un modèle plus complexe qu’envisagé initialement. Cette synthèse indique que les immigrants ont clairement …

Macondo And Leota, Howard Schaap

Faculty Work Comprehensive List

No abstract provided.

Opportunities And Challenges In Incorporating Ancillary Studies Into A Cancer Prevention Randomized Clinical Trial, Phyllis J. Goodman, Catherine M. Tangen, Amy K. Darke, Kathryn B. Arnold, Joann Hartline, Monica Yee, Karen Anderson, Allison Caban-Holt, William G. Christen, Patricia A Cassano, Peter Lance, Eric A. Klein, John J. Crowley, Lori M. Minasian, Frank L. Meyskens

Sanders-Brown Center on Aging Faculty Publications

Background: The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was a randomized, double-blind, placebo-controlled, prostate cancer prevention study funded by the National Cancer Institute and conducted by SWOG (Southwest Oncology Group). A total of 35,533 men were assigned randomly to one of four treatment groups (vitamin E + placebo, selenium + placebo, vitamin E + selenium, placebo + placebo). At the time of the trial’s development, NIH had invested substantial resources in evaluating the potential benefits of these antioxidants. To capitalize on the knowledge gained from following a large cohort of healthy, aging males on the effects of selenium …

Primetimes Newsletter, Fall 2016, Office Of Lifespan Studies

PrimeTimes Newsletter

PrimeTimes is the newsletter of the Office of Lifespan Studies in the College of Science at Coastal Carolina University.

Outliving Love: Marital Estrangement In An African Insurance Market, Casey Golomski

Anthropology

Marital estrangement and formal divorce are vital conjunctures for married women’s kinship relations and life course, where a horizon of future possibilities are revalued and negotiated at the interstices of custom, law, and social and ritual obligations. In this article, after delineating the forms of customary and civil marriage and the possibilities for divorce or estrangement from each, I describe how some married women in Swaziland and South Africa mediate this complex social field for their children and families through pensions and continuing to pay for their partners’ insurance coverage. This was not solely out of avarice to reap future …

Black Gentrification Twice Removed: A Study Of Migration And Community Involvement In Washington, Dc, Janwin A. Zeegar-Holman

Capstone Collection

This paper is about Black people and community involvement against the backdrop of gentrification in Washington, DC, and possibility of Black-led neighborhood revitalization. My practicum in Southeast Washington DC compelled me to examine the ability of a Black person in Washington DC to sustain commitment to a community that they do not live in, and if Black people moving to gentrifying areas of Washington DC can help the predominantly Black non-gentrifying areas to gentrify on their own terms.

This paper focuses specifically on Black individuals who have spent time in DC and proposed ways that Black non-gentrifying communities can revitalize …

Perceived Emotional Invalidation In A Developmental Context: Does Gender Matter?, Brian B. Johnson

USC Aiken Psychology Theses

Emotional invalidation is the dismissal, minimization, or punishment of an individual’s emotional experience (Linehan, 1993). Although it has been sparsely studied, the research that has been conducted indicates that it is likely implicated in a multitude of psychopathology and adjustment issues. The current study had three main objectives. The first of these was to investigate the current perceptions of emotional invalidation in a peer interaction for emerging adults and how that is predicted by gender, perceptions of childhood emotional invalidation via caregivers, and gender of the caregivers. The second objective of this study was to investigate the propagation of emotionally …

Breastfeeding Matters : Infant Feeding Decision Making And Mothering Sense Of Competence Among Korean American Mothers, Soo-Bin You

Theses, Dissertations and Culminating Projects

The current study examined the influence of ecological variables in breastfeeding role expectations on mothers’ sense of competence in infant care, and the mediating effect of breastfeeding experience of mothers on the relationship between breastfeeding role expectations and mothering sense of competence. Thirty nine Korean American mothers who have babies under 18 months old participated in the survey asking about various ecological factors in breastfeeding role expectation, their actual breastfeeding experience, and mothering sense of competence. Findings suggested that each ecological variable (i.e. mother self, baby, family, and community) influencing Korean American mothers’ breastfeeding role expectation was differently related to …

The Father Motive: Predicting The Impact Of Father Attitudes On Involvement, Nathan Lovell Robbins

Theses and Dissertations

The purpose of this study was to evaluate the effects that a man's attitudes towards fathering have on the level of involvement with his children. Of particular interest was whether fathering attitudes moderated some of the more consistent predictors of involvement, such as relationship quality, maternal gatekeeping, mother's and father's employment hours, a man's history with his own father, family structure, and child characteristics. A sample of 2300 men was used to evaluate the effects of fathering attitudes on engagement and warmth among children ages 2 to 8 and 9 to 11. Results indicate an inconsistent main effect between fathering …

Tiers 1, 2 & 3 Intervention: Pyramid Model For Early Childhood Education, Allison Heifner, Jan Thelan, Christine Marvin, Emily A. Dorsey, Teresa Berube, Ana Damme, Reece L. Peterson

Department of Special Education and Communication Disorders: Faculty Publications

Conclusion

The Pyramid Model represents a comprehensive effort to provide teachers, caregivers, and families the tools and strategies needed to promote and support positive behavior, prevent challenging behavior, and address the social needs of all young children. The Pyramid Model emphasizes data-based decision making, employs evidence based prevention and intervention practices, and matches the intensity of behavior intervention to the intensity level of behavior for those children in need of individual support. The Pyramid Model provides a program- wide approach for use by early childhood teachers, caregivers, and families to support the social-emotional development of young children and decrease or …

Care, Constraint, And Collaboration : Situating Gender And Power Among Multidisciplinary Human Service Organizations., Christa Jane Moore

Electronic Theses and Dissertations

This study incorporated a feminist approach to the use of multiple qualitative methods by conducting participant observation, focus group interviewing, and in-depth interviewing of women and men affiliated with a diverse representation of human service organizations. An applied research partnership with a multi-county human service organization provided entrée to the study population. Through analytic induction using a grounded theoretical approach the study explored perceptions of power, authority, gender, inequality, and bureaucratic constraints that emerged during organizational processes of interagency collaboration among multidisciplinary human service organizations (Charmaz 2014; Corbin and Strauss 2014). Findings indicate that establishing relationships is critical for interagency …

Eight Reasons Women Stay In Abusive Relationships, Jason B. Whiting

Faculty Publications

When NFL linebacker Ray Rice knocked his fiancée Janay Palmer unconscious in an elevator in 2014, it didn't initially get much attention. He was accused of domestic violence and suspended for two games. After a few weeks he was formally charged, but he and Palmer were married the next day. However, when a security video of the event surfaced, it quickly went viral. Watching Palmer get knocked out and roughly dragged out of the elevator by Rice had a powerful effect on viewers. The waves of outrage that followed caused the NFL to scramble to increase their punishment of Ray …

Nebraska's Wedding Crasher, Jennine Capó Crucet

Department of English: Faculty Publications

My building thinks of itself as Lincoln's premier wedding venue. I was not told this when I signed the lease. A glitch of duct work sends the sounds of every single party straight through the exhaust fan of my apartment's bathroom, so loud and clear that I can hear the names of everyone in the wedding party as they are announced -- not just in the bathroom, but from the living room. I can hear when people are clapping, can hear the claps as individual sonic events: I can almost always make out the crisp echo of the last person …