Prediction Of Disease-Free Survival For Precision Medicine Using Cooperative Learning On Multi-Omic Data,
2024
The Texas Medical Center Library
Prediction Of Disease-Free Survival For Precision Medicine Using Cooperative Learning On Multi-Omic Data, Georg Hahn, Dmitry Prokopenko, Julian Hecker, Sharon M Lutz, Kristina Mullin, Leinal Sejour, Winston Hide, Ioannis Vlachos, Stacia Desantis, Rudolph E Tanzi, Christoph Lange
Faculty, Staff and Student Publications
In precision medicine, both predicting the disease susceptibility of an individual and forecasting its disease-free survival are areas of key research. Besides the classical epidemiological predictor variables, data from multiple (omic) platforms are increasingly available. To integrate this wealth of information, we propose new methodology to combine both cooperative learning, a recent approach to leverage the predictive power of several datasets, and polygenic hazard score models. Polygenic hazard score models provide a practitioner with a more differentiated view of the predicted disease-free survival than the one given by merely a point estimate, for instance computed with a polygenic risk score. …
Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function,
2024
CUNY Bernard M Baruch College
Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander
Student Theses and Dissertations
Aerobic metabolism is known to generate damaging ROS, particularly hydrogen peroxide. Reactive oxygen species (ROS) are highly reactive molecules containing oxygen that have the potential to cause damage to cells and tissues in the body. ROS are highly reactive atoms or molecules that rapidly interact with other molecules within a cell. Intracellular accumulation can result in oxidative damage, dysfunction, and cell death. Due to the limitations of H2O2 (hydrogen peroxide) detectors, other impacts of ROS exposure may have been missed. HyPer7, a genetically encoded sensor, measures hydrogen peroxide emissions precisely and sensitively, even at sublethal levels, during …
Parents’ Perception Of An Intensive Interdisciplinary Pain Treatment For Amplified Pain Syndrome,
2024
Children's Mercy Kansas City
Parents’ Perception Of An Intensive Interdisciplinary Pain Treatment For Amplified Pain Syndrome, Jacqueline Pabis Phd, Sabrina Ung Ma, Jenny Scheurich Phd, Dustin Wallace Phd
Research Days
This study examines overall parent satisfaction with Intensive interdisciplinary pain treatment for youth with amplified pain syndrome. Additionally, it evaluates the relationship between parent-provider communication and satisfaction, as well as with perceived child outcomes.
Bridging Services To Evidenced-Based Care: Implementing A Psychology Consult Check-Up Clinic,
2024
Children's Mercy Kansas City
Bridging Services To Evidenced-Based Care: Implementing A Psychology Consult Check-Up Clinic, Jacqueline Pabis Phd, Sabrina Ung Ma, Angela Combs Ma, Mallory Netz Phd, Carisa Parrish Phd, Casey Lawless Phd
Research Days
This quality improvement project examines the feasibility, satisfaction, and preliminary outcomes of a hospital follow-up program for the CMH Inpatient Psychology Consultation & Liaison team.
The Impact Of Perceived Self-Connection On Possession-Based Placebo Analgesia : An Investigation Using Implicit And Explicit Measures,
2024
Lingnan University
The Impact Of Perceived Self-Connection On Possession-Based Placebo Analgesia : An Investigation Using Implicit And Explicit Measures, Sze Ki Ng
Lingnan Theses (MPhil & PhD)
Previous study found merely possessing a placebo analgesic cream (without using) has similar pain outcomes when it is compared with using a placebo analgesic cream, but the underlying mechanism is unclear (Yeung et al., 2019). Yeung et al. (2020) proposed that an object-to-self expectancy can be a possible mechanism underlying a possession-based placebo effect, which means people believe that the owned object will benefit them. The present study aimed to examine this hypothetical mechanism and investigate how forming a cognitive connection between the analgesic cream and the self affects the possession-based placebo effect. We demonstrated the effect existed and observed …
Female Medical Students’ Lived Experiences Of Financial Stress And Coping,
2024
Walden University
Female Medical Students’ Lived Experiences Of Financial Stress And Coping, Untara Shaikh, Dr. Kimberlee Bonura
Georgia Public Health Association Annual Meeting & Conference
Financial stress is a pervasive concern among medical students, with documented associations with adverse physical health, psychological morbidity, and ineffective coping. This study focuses on understanding the financial stressors female medical students face and the coping strategies they employ. While financial stress and coping mechanisms have been explored in the literature, a notable gap exists in understanding these dynamics among female students.
The study employed a phenomenological research approach to obtain data from the respondents, where data collection involved face-to-face semi-structured interviews. The Adaptation Model of Nursing, complemented by Lazarus and Folkman's Coping Theory, was a comprehensive framework for analyzing …
Assessing Cannabidiol As A Novel Therapeutic For Depression Among College Students,
2024
James Madison University
Assessing Cannabidiol As A Novel Therapeutic For Depression Among College Students, Noah Gustin
Masters Theses, 2020-current
The purpose of the current study was to assess the utility of cannabidiol (CBD) as a novel therapeutic for college students with mild-to-moderate depression. Participants completed a fourteen-week protocol: a four-week baseline, a four-week consumption phase, a two-week washout phase, and a second four-week consumption phase. Participants were randomly assigned to a CBD condition (150mg or 300mg). Study phases were counterbalanced such that if CBD was consumed in the first consumption phase, placebo was consumed in the second consumption phase, and vice versa. Participants completed weekly and monthly surveys used to assess depressive symptoms and secondary health-related measures. While graphical …
Psychosocial Factors Associated With Substance Use Vulnerability In Black Americans,
2024
University of Connecticut
Psychosocial Factors Associated With Substance Use Vulnerability In Black Americans, Aanya Mehta
Honors Scholar Theses
In 2010, the World Health Organization developed the Conceptual Framework for the Social Determinants of Health as a response to epidemiologists’ and public health workers’ need to estimate the impact of social inequality. Within this framework, psychosocial factors are intermediary determinants of health that influence an individual’s interactions with their environment. This paper analyzes data and results from ten articles from the Family and Community Health Study (FACHS), which looks at the impacts of psychosocial, contextual, and family effects on health and developmental outcomes in Black American families. The findings across the ten articles provide strong evidence that there are …
Test Anxiety Inflation,
2024
Northern Illinois University
Test Anxiety Inflation, Brian Podkulski, David P. Valentiner
Honors Capstones
Mental health conditions are higher than ever worldwide, despite best efforts to increase public awareness and deliver informed solutions. To account for this rise, some suggested models argue that measures taken to ameliorate mental health problems are actually contributing to their inflation through iatrogenic effects. The current proposed study seeks to identify the possibility of iatrogenic effects on test anxiety as a product of psychoeducational material. The scope of this study includes the immediate effects of viewing a typical short-form informational video on core and adjacent symptoms of test anxiety. Participants will engage with our study entirely through an online …
An Actuarial Prediction Of Adhd Using Neuropsychological Data,
2024
University of South Alabama
An Actuarial Prediction Of Adhd Using Neuropsychological Data, Kimberlyn Williams
Poster Presentations
Attention-Deficit/Hyperactivity Disorder (ADHD) is the most common psychiatric diagnosis in children and a frequent psychiatric diagnosis in adults. ADHD is a clinical diagnosis based on self-reported symptoms which makes accurate diagnosis challenging. Actuarial prediction has been demonstrated to be more accurate than clinical judgment. The current study explored an actuarial approach to predicting ADHD based on a comprehensive battery of neuropsychological tests. This project utilized test data from Meyers Neuropsychological Battery (MNB) to develop a logistic regression model to accurately predict diagnosed ADHD cases (n=65) from normal functioning cases (n=79) with a history of Mild Traumatic Brain Injury (mTBI). Binary …
Dual-Systems And Fuzzy-Trace Theory Predictions Of Covid-19 Risk Taking In Young Adults,
2024
University of Washington School of Law
Dual-Systems And Fuzzy-Trace Theory Predictions Of Covid-19 Risk Taking In Young Adults, Sarah M. Edelson, Valerie F. Reyna, Bridget B. Hayes, David M. N. Garavito
Articles
Risk-reduction behaviors are the first line of defense in viral epidemics. Choosing to not engage in risk-reduction behaviors produced millions of preventable deaths from COVID-19. Understanding why this happens and how to predict it is important for theory development and public policy. We took four approaches to this problem: experimentally varying theory-driven predictors (social rewards, transmission risk, and mandatory/voluntary regulations) in choice scenarios, further probing choices in specific scenarios predicted to elicit risk taking, conducting hierarchical regressions with demographic and theory-driven predictors for both scenario types, and conducting corresponding regressions for self-reported protective behaviors. The sample consisted of 247 young …
Effectiveness Of A Peer-Supported Digital Brief Intervention: Reducing Alcohol Use & Related Harms In Young Adults With Histories Of Interpersonal Trauma,
2024
Western Kentucky University
Effectiveness Of A Peer-Supported Digital Brief Intervention: Reducing Alcohol Use & Related Harms In Young Adults With Histories Of Interpersonal Trauma, Caitlin Mcgettrick
Masters Theses & Specialist Projects
Alcohol is the most frequently used substance in the United States, and young adults ages 18-25 have the highest rates of heavy alcohol use. Heavy and persistent alcohol use is associated with a host of negative outcomes in young adults, including poor mental health, lower life satisfaction, cognitive impairments, poor academic performance, increased risk for motor vehicle accidents, and substance use disorders. Brief interventions (BI) are low-resource, short-term interventions designed to reduce problematic substance use and mitigate the substantial harms posed by heavy and persistent use of substances such as alcohol. BIs have limited effectiveness in trauma survivors despite trauma …
Meaning In Life And Metacognition: Application Of The Self-Validation Hypothesis,
2024
Western Kentucky University
Meaning In Life And Metacognition: Application Of The Self-Validation Hypothesis, Liam Hill
Masters Theses & Specialist Projects
Meaning in Life is a robust predictor of various positive outcomes, and provides a buffer against a host of negative outcomes. Due to this fact, it becomes important to examine all the facets of a meaningful life. One consistent predictor of Meaning in Life (MIL) in the literature is one’s sense of positive affect. I tested the idea that it is possible to doubt (or have confidence in) one’s affect, such that under conditions of doubt, positive affect is less strongly related to MIL. It may be the case that positive affect predicts MIL because of what we think of …
Impact Of Framing Depression On Illness Perceptions And Coping Strategies,
2024
Western Kentucky University
Impact Of Framing Depression On Illness Perceptions And Coping Strategies, Abby Mcginnis
Masters Theses & Specialist Projects
The current study aimed to adopt an experimental design used by Schroder et al. (2023) to investigate how framing of depression (as a disease vs a functional signal) impacts illness perceptions and coping strategies. Participants were given the Depression Anxiety and Stress Scale (DASS-42) to assess depression severity and prime participants for the framing condition. Each condition had five videos describing depression and the corresponding frameworks. Perceived control, timeline, and causes of depression were measured using the Illness Perception Questionnaire (IPQ-R). Participants were given the brief-COPE questionnaire to measure coping strategies, such as avoidant and problem-focused. There were no differences …
The Tripartite Influence Model Of Body Image And Disordered Eating Among Female Athletes: Testing An Expanded Model,
2024
University of South Alabama
The Tripartite Influence Model Of Body Image And Disordered Eating Among Female Athletes: Testing An Expanded Model, Emma Nyrup Tonsberg
Honors Theses
The aim of the study was to investigate how different sources of sociocultural pressure (family, media, peers) described in the Tripartite Influence Model, and additions of teammate- and coach pressures, were associated with thinness-and muscularity internalization and appearance comparisons among athletes. Subsequently, these potential mechanisms were explored as predictors of disordered eating among athletes. Analyses included 71 female athletes. Athletes were recruited through a student subject pool recruitment portal, as well as with local and regional flyers and emails. Participants completed a series of self-report measures in Qualtrics. Hierarchical linear regression analysis was utilized to test the hypotheses. Partial support …
Examining The Effects Of Menstrual Cycle Phase And Hormonal Contraceptive Use On Women's Sleep,
2024
University of Arkansas, Fayetteville
Examining The Effects Of Menstrual Cycle Phase And Hormonal Contraceptive Use On Women's Sleep, Charles Ethan Coombs
Psychological Science Undergraduate Honors Theses
Women overrepresent men for sub-optimal sleep, a consequence of hormone fluctuation in the menstrual cycle affecting sleep regulatory pathways. While research has examined the prevalence of sub-optimal sleep through cycle phases, little research has examined how hormonal contraceptives (HC’s) could similarly affect women’s sleep, while also neglecting to utilize subjective sleep measures. In this study, we examine subjective sleep quality among naturally cycling (NC) women, women using different HC types, and between active and inactive phase pill users by subjecting 463 women to a subjective sleep battery. We hypothesized that HC users would report more sub-optimal sleep than NC women. …
Believe In Yourself And Keep The Doctor Away: Health Self-Efficacy Mediates The Relationship Between Retrospectively Reported Adverse Childhood Experiences (Aces) And College Students’ Current Self-Reported Physical Health,
2024
University of Arkansas, Fayetteville
Believe In Yourself And Keep The Doctor Away: Health Self-Efficacy Mediates The Relationship Between Retrospectively Reported Adverse Childhood Experiences (Aces) And College Students’ Current Self-Reported Physical Health, Amber Sale
Psychological Science Undergraduate Honors Theses
Adverse childhood experiences (ACEs) are potentially traumatic events occurring during the first 18 years of life (CDC, 2022) and are strong predictors of later negative outcomes such as poor physical health, risky health behaviors, and poor lifestyle habits (Felitti et al., 1998; Lovis-Schmidt et al., 2022; Windle et al., 2018). Previous literature has suggested that self-efficacy may explain the negative impact ACEs have on later physical health (Sachs-Ericsson et al., 2011). Therefore, the present study examined the relationship between college students’ retrospectively reported ACEs and current self-reported physical health, in the context of health self-efficacy levels (i.e., self-perceptions of one’s …
Victim Or Villain: Female Resilience And Agency In The Face Of Trauma In Chimamanda Adichie’S, Purple Hibiscus (2003) And Tsitsi Dangarembga’S, Nervous Conditions (1988),
2024
East Tennessee State University
Victim Or Villain: Female Resilience And Agency In The Face Of Trauma In Chimamanda Adichie’S, Purple Hibiscus (2003) And Tsitsi Dangarembga’S, Nervous Conditions (1988), Adaobi Juliet Chukwuma
Electronic Theses and Dissertations
As long as disparities persist in the way women are treated as compared to their male counterparts, the issue of gender will continue to call forth literary productions. For this reason, female writers are on a mission to dismantle the stereotypes that keep women confined to societal roles. Grounded in a feminist framework, this study focuses on the gender disparity theme in Chimamanda Adichie’s Purple Hibiscus and Tsitsi Dangarembga’s Nervous Conditions. The aim is to examine how these writers represent the trauma of women living in an African patriarchal system. The traumatic experiences of the female characters in both texts …
The Role Of Social Support And Emotional Regulation In Relationship With Adverse Childhood Experiences And Food Addiction,
2024
California State University, San Bernardino
The Role Of Social Support And Emotional Regulation In Relationship With Adverse Childhood Experiences And Food Addiction, Negin Ghaffari
Electronic Theses, Projects, and Dissertations
Adverse childhood experiences (ACEs) are potentially traumatic experiences that occur before the age of 18 and can have long-standing impacts on mental and physical health. Individuals with high exposure to ACEs may be at increased risk for depression, substance use disorders, and cardiovascular disease (Hughes et al., 2017). Social support has been shown to play an essential role in reducing the likelihood of adverse outcomes, such as substance dependence following exposure to adverse experiences. Furthermore, emotional regulation difficulties have been shown to mediate the relationship between childhood trauma and food addiction. There has been little research on adverse events in …
Psychological Mediation Of Minority Stress And Health: Exploration Of Risk Factors In Lgbq College Students,
2024
East Tennessee State University
Psychological Mediation Of Minority Stress And Health: Exploration Of Risk Factors In Lgbq College Students, Kyndal Grammer
Electronic Theses and Dissertations
Decades of research have documented pervasive physical and mental health disparities among individuals holding a marginalized identity, including those who identify as lesbian, gay, bisexual, or queer (LGBQ). Heterosexism in the forms of harassment, rejection, and discrimination likely increases minority stress, which is theorized to contribute to documented health disparities. One group that may be particularly vulnerable to effects of heterosexist discrimination, harassment, and rejection is LGBQ college students, especially those who identify as first-generation and were raised in rural environments. The current study aimed to evaluate relationships between LGBQ discrimination, depression, and physical health outcomes at the bivariate level, …
