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Articles 391 - 420 of 455
Full-Text Articles in Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
12th Annual Pacific Research Day Abstracts, University Of The Pacific
12th Annual Pacific Research Day Abstracts, University Of The Pacific
Excellence Day
No abstract provided.
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
11th Annual Pacific Research Day Abstracts, University Of The Pacific
11th Annual Pacific Research Day Abstracts, University Of The Pacific
Excellence Day
No abstract provided.
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
Pick1 Deficiency Causes Male Infertility In Mice By Disrupting Acrosome Formation, Nan (Tori) Xiao, Chuen Kam, Chong Shen, Wenying Jin, Junqi Wang, Kwong Man Lee, Liwen Jiang, Jun Xia
Pick1 Deficiency Causes Male Infertility In Mice By Disrupting Acrosome Formation, Nan (Tori) Xiao, Chuen Kam, Chong Shen, Wenying Jin, Junqi Wang, Kwong Man Lee, Liwen Jiang, Jun Xia
All Dugoni School of Dentistry Faculty Articles
Protein interacting with C kinase 1 (PICK1) is a peripheral membrane protein involved in protein trafficking, a function that has been well characterized in neurons. Here, we report that male mice deficient in PICK1 are infertile and have a phenotype resembling the human disease globozoospermia. The primary defect in the testes of Pick1-knockout mice was fragmentation of acrosomes in the early stages of spermiogenesis. This fragmentation was followed by defects in nuclear elongation and mitochondrial sheath formation, leading to round-headed sperm, reduced sperm count, and severely impaired sperm motility. We found that PICK1 interacted with Golgi-associated PDZ- and coiled-coil motif-containing …
Transferrin Lipoplex-Mediated Suicide Gene Therapy Of Oral Squamous Cell Carcinoma In An Immunocompetent Murine Model And Mechanisms Involved In The Antitumoral Response, S. Neves, Henrique Faneca, S. Bertin, Krystyna Konopka, Nejat Düzgüneş, V. Pierrefite-Carle, S. Simões, M. C. Pedroso De Lima
Transferrin Lipoplex-Mediated Suicide Gene Therapy Of Oral Squamous Cell Carcinoma In An Immunocompetent Murine Model And Mechanisms Involved In The Antitumoral Response, S. Neves, Henrique Faneca, S. Bertin, Krystyna Konopka, Nejat Düzgüneş, V. Pierrefite-Carle, S. Simões, M. C. Pedroso De Lima
All Dugoni School of Dentistry Faculty Articles
Suicide gene therapy has been used for the treatment of a variety of cancers. We reported previously the in vitro efficacy of the Herpes Simplex Virus Thymidine kinase (HSV-tk)/ganciclovir (GCV) system to mediate cytotoxicity in oral squamous cancer cells, using transferrin (Tf)-lipoplexes, prepared from cationic liposomes composed of 1,2-dioleoyl-3-(trimethylammonium) propane (DOTAP) and cholesterol. In the present study, we evaluated the antitumoral efficacy mediated by this lipoplex formulation in two suicide gene therapy strategies, HSV-tk/GCV and cytosine deaminase (CD)/5-fluorocytosine (5-FC), using a syngeneic, orthotopic murine model for head and neck squamous cell carcinoma. The cellular and molecular events associated with the …
Correlation Between The Levels Of Survivin And Survivin Promoter-Driven Gene Expression In Cancer And Non-Cancer Cells, Krystyna Konopka, Christopher Spain, Allison Yen, Nathan Overlid, Senait Gebremedhin, Nejat Düzgüneş
Correlation Between The Levels Of Survivin And Survivin Promoter-Driven Gene Expression In Cancer And Non-Cancer Cells, Krystyna Konopka, Christopher Spain, Allison Yen, Nathan Overlid, Senait Gebremedhin, Nejat Düzgüneş
All Dugoni School of Dentistry Faculty Articles
Survivin, a member of the inhibitor of apoptosis (IAP) protein family, is associated with malignant transformation and is over-expressed in most human tumors. Using lipoplex-mediated transfection, we evaluated the activity of the reporter enzyme, luciferase, expressed from plasmids encoding the enzyme under the control of either the cytomegalovirus (CMV) or survivin promoters, in tumor- and non-tumor-derived human and murine cells. We also examined whether there is a correlation between the survivin promoter-driven expression of luciferase and the level of endogenous survivin. Human cancer cells (HeLa, KB, HSC-3, H357, H376, H413), oral keratinocytes, GMSM-K, and chemically immortalized human mammary cells, 184A-1, …
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
Enzastaurin, An Inhibitor Of Pkc Beta, Enhances Antiangiogenic Effects And Cytotoxicity Of Radiation Against Endothelial Cells., Aaron C. Spalding, Benjamin David Zeitlin, Kari Wilder-Romans, Mary Ellen Davis, Jacques E. Nör, Theodore S. Lawrence, Edgar Ben-Josef
Enzastaurin, An Inhibitor Of Pkc Beta, Enhances Antiangiogenic Effects And Cytotoxicity Of Radiation Against Endothelial Cells., Aaron C. Spalding, Benjamin David Zeitlin, Kari Wilder-Romans, Mary Ellen Davis, Jacques E. Nör, Theodore S. Lawrence, Edgar Ben-Josef
All Dugoni School of Dentistry Faculty Articles
PURPOSE: Angiogenesis plays an important role in pancreas cancer pathobiology. Pancreatic tumor cells secrete vascular endothelial growth factor (VEGF), activating endothelial cell protein kinase C beta (PKC beta) that phosphorylates GSK3 beta to suppress apoptosis and promote endothelial cell proliferation and microvessel formation. We used Enzastaurin (Enz) to test the hypothesis that inhibition of PKC beta results in radiosensitization of endothelial cells in culture and in vivo. MATERIALS/METHODS: We measured PKC beta phosphorylation, VEGF pathway signaling, colony formation, and capillary sprout formation in primary human dermal microvessel endothelial cells (HDMECs) after Enz or radiation (RT) treatment. Microvessel density and tumor …
Expanding Circle Of Inhibition: Small-Molecule Inhibitors Of Bcl-2 Asanticancer Cell And Antiangiogenic Agents, Benjamin David Zeitlin, Isaac J. Zeitlin, Jacques E. Nör
Expanding Circle Of Inhibition: Small-Molecule Inhibitors Of Bcl-2 Asanticancer Cell And Antiangiogenic Agents, Benjamin David Zeitlin, Isaac J. Zeitlin, Jacques E. Nör
All Dugoni School of Dentistry Faculty Articles
The specific targeting of diseases, particularly cancer, is a primary aim in drug development, as specificity reduces unwelcome effects on healthy tissue and increases drug efficacy at the target site. Drug specificity can be increased by improving the delivery system or by selecting drugs with affinity for a molecular ligand specific to the disease state. The role of the prosurvival Bcl-2 protein in maintaining the normal balance between apoptosis and cellular survival has been recognized for more than a decade. Bcl-2 is vital during development, much less so in adults. It has also been noted that some cancers evade apoptosis …
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
10th Annual Pacific Research Day Abstracts, University Of The Pacific
10th Annual Pacific Research Day Abstracts, University Of The Pacific
Excellence Day
No abstract provided.
Longitudinal Evaluation Of Prostaglandin E2 (Pge2) And Periodontal Status In Hiv+ Patients, Tamer Alpagot, John Remien, Mouchumi Bhattacharyya, Krystyna Konopka, William Lundergan, Nejat Düzgüneş
Longitudinal Evaluation Of Prostaglandin E2 (Pge2) And Periodontal Status In Hiv+ Patients, Tamer Alpagot, John Remien, Mouchumi Bhattacharyya, Krystyna Konopka, William Lundergan, Nejat Düzgüneş
All Dugoni School of Dentistry Faculty Articles
The study aim was to determine whether prostaglandin E2 (PGE2) in gingival crevicular fluid (GCF) could serve as a risk factor for periodontitis in human immunodeficiency virus-positive (HIV+) patients. Clinical measurements, including gingival index (GI), plaque index, bleeding index, probing depth (PD), attachment loss (AL) and GCF samples were taken from two healthy sites (including sites with gingival recession, GI = 0; PD ≤ 3 mm; AL ≤ 2 mm), three gingivitis sites (GI > 0; PD ≤ 3 mm; AL = 0) and three periodontitis sites (GI > 0; PD ≥ 5 mm; AL ≥ 3 mm) of each of the …
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
9th Annual Pacific Research Day Abstracts, University Of The Pacific
9th Annual Pacific Research Day Abstracts, University Of The Pacific
Excellence Day
No abstract provided.
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
Serum Decreases The Size Of Metafectene- And Genejammer-Dna Complexes But Does Not Affect Significantly Their Transfection Activity In Sccvii Murine Squamous Cell Carcinoma Cells, Krystyna Konopka, Nathan Overlid, Anitha C. Nagaraj, Nejat Düzgüneş
Serum Decreases The Size Of Metafectene- And Genejammer-Dna Complexes But Does Not Affect Significantly Their Transfection Activity In Sccvii Murine Squamous Cell Carcinoma Cells, Krystyna Konopka, Nathan Overlid, Anitha C. Nagaraj, Nejat Düzgüneş
All Dugoni School of Dentistry Faculty Articles
Cationic liposome-DNA (lipoplexes) or polymer-DNA (polyplexes) complexes have been used to deliver therapeutic genes, both in vitro and in vivo. However, gene transfer by these non-viral vectors is usually inhibited by biological milieu. A relatively high efficiency of transfection could be achieved in human oral cancer cells transfected with the polycationic liposome, Metafectene, and the polyamine reagent, GeneJammer, in the presence of 60% fetal bovine serum (FBS) (Konopka et al., Cell. Mol. Biol. Lett. 10 (2005) 455-470). Here, we examined the efficacy of these vectors to deliver β-galactosidase (β-gal), luciferase and Herpes Simplex Virus thymidine kinase (HSV-tk) genes to SCCVII …
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point, Arthur A. Dugoni School Of Dentistry
Contact Point
No abstract provided.
7th Annual Pacific Research Day Abstracts, University Of The Pacific
7th Annual Pacific Research Day Abstracts, University Of The Pacific
Excellence Day
No abstract provided.
6th Annual Pacific Research Day Abstracts, University Of The Pacific
6th Annual Pacific Research Day Abstracts, University Of The Pacific
Excellence Day
No abstract provided.
On The Formulation Of Ph-Sensitive Liposomes With Long Circulation Times, Sérgio Simões, João Nuno Moreira, Cristina Fonseca, Nejat Düzgüneş, Maria C. Pedroso De Lima
On The Formulation Of Ph-Sensitive Liposomes With Long Circulation Times, Sérgio Simões, João Nuno Moreira, Cristina Fonseca, Nejat Düzgüneş, Maria C. Pedroso De Lima
All Dugoni School of Dentistry Faculty Articles
Strategies used to enhance liposome-mediated drug delivery in vivo include the enhancement of stability and circulation time in the bloodstream, targeting to specific tissues or cells, and facilitation of intracytoplasmic delivery. pH-sensitive liposomes have been developed to mediate the introduction of highly hydrophilic molecules or macromolecules into the cytoplasm. These liposomes destabilize under acidic conditions found in the endocytotic pathway, and usually contain phosphatidylethanolamine (PE) and titratable stabilizing amphiphiles. Formulations without PE have also been developed. Encapsulated compounds are thought to be transported into the cytoplasm through destabilization of or fusion with the endosome membrane. Incorporation of a low mole …
The Shape Parameter Of Liposomes And Dna-Lipid Complexes Determined By Viscometry Utilizing Small Sample Volumes, Yan Sun, X. Li, Nejat Düzgüneş, Y. Takaoka, S. Ohi, S. Hirota
The Shape Parameter Of Liposomes And Dna-Lipid Complexes Determined By Viscometry Utilizing Small Sample Volumes, Yan Sun, X. Li, Nejat Düzgüneş, Y. Takaoka, S. Ohi, S. Hirota
All Dugoni School of Dentistry Faculty Articles
A minicapillary viscometer utilizing <0.5 ml of sample at a volume fraction of <0.1% is described. The calculated a/b of DPPC/DPPG multilamellar liposome was 1.14 as prolate ellipsoids and a/b of dioleoylpropyltrimethyl ammonium methylsulfate-DNA complex at a charge ratio of 4:1 (+/-) was 3.7 as prolate ellipsoids or 4.9 as oblate ellipsoids. The deviation of shape from perfect sphere is thus expressed quantitatively in more than two significant figures. In these measurement, the necessary amount of DNA is <0.5 mg.
5th Annual Pacific Research Day Abstracts, University Of The Pacific
5th Annual Pacific Research Day Abstracts, University Of The Pacific
Excellence Day
No abstract provided.
Increased Receptor-Mediated Gene Delivery To The Liver By Protamine-Enhanced-Asialofetuin-Lipoplexes, M. A. Arangoa, Nejat Düzgüneş, C. Tros De Ilarduya
Increased Receptor-Mediated Gene Delivery To The Liver By Protamine-Enhanced-Asialofetuin-Lipoplexes, M. A. Arangoa, Nejat Düzgüneş, C. Tros De Ilarduya
All Dugoni School of Dentistry Faculty Articles
A novel lipidic vector composed of DOTAP/Chol liposomes, asialofetuin (AF), protamine sulfate and DNA has been developed. The resulting protamine-AF-lipoplexes improved significantly the levels of gene expression in cultured cells and in the liver upon i.v. administration. Lipoplexes containing the optimal amount of AF (1 μg/μg DNA) showed a 16-fold higher transfection activity in HepG2 cells than non-targeted (plain) complexes. The uptake by cells having asialoglycoprotein receptors (ASGPr) on their plasma membrane was decreased by the addition of free AF, indicating that AF-lipoplexes were taken up specifically by cells via ASGPr-mediated endocytosis. Results from transfections performed in cells defective in …