Other Nutrition Commons^™

The Effects Of Sodium Bicarbonate Supplementation On Lower-Body Hypertrophy-Type Resistance Exercise, Benjamin Mclean Carr

Dissertations

A number of studies have demonstrated the ergogenic effects of induced-alkalosis on high-intensity intermittent exercise performance. Purpose: The aim of the present study was to examine the effects of sodium bicarbonate (NaHCO₃) administration on a high-volume hypertrophy-type resistance exercise regimen for the lower body. Methods: In a double-blind counterbalanced manner, 12 resistance-trained male participants (mean ± SD; age = 20.3 ± 2 yr, mass = 88.3 ± 13.2 kg, height = 1.80 ± 0.07 m), with a minimum of two years of training experience, ingested either 0.3 g˙kg^-1 of NaHCO₃ or calcium carbonate (CaCO₃) …

Examining Dietary Acculturation In Hispanic Males Residing In South Mississippi, Diana Katherine Cuy Castellanos

Dissertations

This study explored dietary behavior in terms of dietary intake, dietary intake change and dietary contributing factors in a sample of Hispanic males residing in southern Mississippi that are at various stages of the acculturation process. Grounded theory and the bidimensional acculturation model were incorporated to identify the dietary factors and assess acculturation in each participant. Qualitative and quantitative measures were used in data collection. Qualitative measurements included Semistructured interviews, a focus group, and photovoice with group interviews. The ARSMA-II, Marginality Scale, Fruit/Vegetable and Fat Food Screeners, a psychosocial dietary questionnaire, and the New Vital Signs Food Label for Health …

Unsaturated Fatty Acids Repress The Expression Of Atp-Binding Cassette Transporter A1 In Hepg2 And Fhs 74 Int Cells, Chai Siah Ku, Heather E. Rasmussen, Young-Ki Park, Elliot D. Jesch, Ji-Young Lee

Department of Nutrition and Health Sciences: Faculty Publications

Adenosine triphosphate–binding cassette transporter A1 (ABCA1) plays a critical role in the formation and metabolism of high-density lipoproteins (HDLs). Adenosine triphosphate–binding cassette transporter A1 in the liver and small intestine, in particular, accounts for approximately 90% of plasma HDL cholesterol. Therefore, any alterations in the hepatic and intestinal expression of ABCA1 could have a large impact on HDL biogenesis. We tested the hypothesis that ABCA1 expression is regulated differentially by different types of fatty acids in the liver and small intestine. Human hepatoma HepG2 and human small intestine epithelial FHs 74 Int cells were used as an in vitro model. …

Effect Of Brown Midrib Corn Silage And Dried Distillers Grains Plus Solubles On Lactational Performance And Nitrogen Utilization By Dairy Cows, Hugo A. Ramirez

Department of Animal Science: Dissertations, Theses, and Student Research

Thirty six Holstein cows, four ruminally cannulated, (mean ± SD, 111 ± 35 DIM; 664 ± 76.5 kg BW) were used in replicated 4×4 Latin squares to investigate the effects of brown midrib (bm3) and conventional (DP) corn silages, and the inclusion of dried distillers grains plus solubles (DDGS) on milk production and N utilization. In each 28 d period cows were assigned to one of four treatments: DP plus 0% DDGS (CON); bm3 plus 0% DDGS (BMR); DP corn silage plus 30% DDGS (DP+DG); and bm3 plus 30% DDGS (BMR+DG). Dry matter intake was greater (P < 0.01) for cows consuming bm3 (25.8 VS 24.4 ± 0.47 kg), likewise for DDGS (24.3 and 25.9 ± 0.47 kg/d for 0 and 30%). Compared to DP hybrid, NDFD was higher (P < 0.01) for bm3 (32.5 VS 38.1 ± 1.79%). There was a hybrid × DDGS interaction (P < 0.01) for total concentration of volatile fatty acids (VFA) and rumen pH as the highly digestible treatment BMR+DG resulted in the highest VFA and the lowest pH. Milk yield was not affected by treatment and averaged 30.6 ± 1.09 kg/d. Milk protein yield (MPY) was greater (P < 0.01) for bm3 and DDGS treatments. There was a hybrid by DDGS interaction (P = 0.02) for milk fat yield (MFY) resulting in 1.03, 1.08, 0.84 and 0.78 ± 0.045 kg/d for DP, BMR, DP+DG and BMR+DG. Fat corrected milk (FCM) was affected by DDGS (P < 0.01) and averaged 30.0 and 26.4 ± 1.0kg/d (0% and 30% inclusions). Urinary N excretion was similar among treatments; however fecal N was lower (P = 0.03) for diets containing bm3 corn silage which caused lower (P = 0.02) manure N. These results indicate that bm3 corn silage and DDGS increase DMI, NDFD and MPY; however high inclusion of corn silage with 30% DDGS reduces FCM. Nitrogen excretion was reduced when cows consumed bm3.

Adipose Tissue Abca1 Contributes To Hdl Biogenesis In Vivo, Soonkyu Chung, Janet K. Sawyer, Abraham K. Gebre, Nobuyo Maeba, John S. Parks

Department of Nutrition and Health Sciences: Faculty Publications

Background—Adipose tissue (AT) is the body’s largest free cholesterol (FC) reservoir and abundantly expresses ATP binding cassette transporter A1 (ABCA1), a key cholesterol transporter for HDL biogenesis. However, the extent to which AT ABCA1 expression contributes to HDL biogenesis in vivo is unknown.

Methods and Results—Adipocyte-specific ABCA1 knockout mice (ABCA1^−A/−A) were

generated by crossing ABCA1floxed mice with aP2 cre transgenic mice. AT from ABCA1^−A/−A mice had −^A/−A mice had a twofold increase in FC content, compared to WT mice, and failed to efflux cholesterol to apoA-I. …

The Role Of Histone H4 Biotinylation In The Structure Of Nucleosomes, Nina A. Filenko, Carol Kolar, John T. West, S. Abbie Smith, Yousef I. Hassan, Gloria E. O. Borgstahl, Janos Zempleni, Yuri L. Lyubchenko

Department of Nutrition and Health Sciences: Faculty Publications

Background: Post-translational modifications of histones play important roles in regulating nucleosome structure and gene transcription. It has been shown that biotinylation of histone H4 at lysine-12 in histone H4 (K12Bio-H4) is associated with repression of a number of genes. We hypothesized that biotinylation modifies the physical structure of nucleosomes, and that biotin-induced conformational changes contribute to gene silencing associated with histone biotinylation.

Methodology/Principal Findings: To test this hypothesis we used atomic force microscopy to directly analyze structures of nucleosomes formed with biotin-modified and non-modified H4. The analysis of the AFM images revealed a 13% increase in the length of …

Body Mass Index Is Associated With Dietary Patterns And Health Conditions In Georgia Centenarians, Dorothy B. Hausman, Mary Ann Johnson, Adam Davey, Leonard W. Poon

Department of Nutrition and Health Sciences: Faculty Publications

Associations between body mass index (BMI) and dietary patterns and health conditions were explored in a population-based multiethnic sample of centenarians from northern Georgia. BMI ≤20 and ≥25 was prevalent in 30.9% and 25.3% of study participants, respectively. In a series of logistic regression analyses controlled for gender and place of residence, the probability of having BMI ≥25 was increased by being black versus white and having a low citrus fruit, noncitrus fruit, orange/yellow vegetable or total fruit and vegetable intake. The probability of having BMI ≤20 was not associated with dietary intake. When controlled for race, gender, residence, and …

Interaction Between Roughages And Corn Milling Byproducts In Finishing Cattle Diets, Joshua R. Benton

Department of Animal Science: Dissertations, Theses, and Student Research

During ethanol production, starch is the primary nutrient fermented and the remaining byproducts are excellent sources of fiber and protein. In addition, inclusion of byproducts in finishing diets may reduce the incidence of acidosis. As a result, roughage level and quality could potentially be reduced in finishing diets containing byproducts. Three experiments were conducted to examine the effects of roughage and wet corn gluten feed (WCGF) in finishing cattle diets containing corn distillers grains plus solubles. Cattle fed finishing diets containing wet distillers grains plus solubles (WDGS) with no roughage had decreased DMI and ADG compared to cattle fed roughage. …

Combined Therapy Of Dietary Fish Oil And Stearoyl-Coa Desaturase 1 Inhibition Prevents The Metabolic Syndrome And Atherosclerosis, J. Mark Brown, Soonkyu Chung, Janet K. Sawyer, Chiara Degirolamo, Heather M. Alger, Tam M. Nguyen, Xuewei Zhu, My-Ngan Duong, Amanda L. Brown, Caleb Lord, Ramesh Shah, Matthew A. Davis, Kathryn Kelley, Martha D. Wilson, Jennifer Madenspacher, Michael B. Fessler, John S. Parks, Lawrence L. Rudel

Department of Nutrition and Health Sciences: Faculty Publications

Background—Stearoyl-CoA desaturase 1 (SCD1) is a critical regulator of energy metabolism and inflammation. We have previously reported that inhibition of SCD1 in hyperlipidemic mice fed a saturated fatty acid (SFA)-enriched diet prevented development of the metabolic syndrome, yet surprisingly promoted severe atherosclerosis. In this study we tested whether dietary fish oil supplementation could prevent the accelerated atherosclerosis caused by SCD1 inhibition.

Methods and Results—LDLr^-/-, ApoB^100/100 mice were fed diets enriched in saturated fat or fish oil in conjunction with antisense oligonucleotide (ASO) treatment to inhibit SCD1. As previously reported, in SFA-fed mice, SCD1 inhibition dramatically protected against …

‘Food For Life’: Looking Beyond The Horizon, Charles A. Francis, John W. Doran

Department of Agronomy and Horticulture: Faculty Publications

Our real challenge appears to be anticipating what the major challenges and constraints will be to food production and distribution a decade or more into the future. This could be called ‘Beyond the Horizon’ thinking. Today there is little disagreement over the massive depletion on a global scale of two essential inputs to agriculture: fossil fuels and fresh water. We also recognize that phosphorus is found in concentrated form in only a few deposits in nature, and that agriculture is rapidly using this limited resource and dispersing it through harvested products and soil loss from fields in forms that make …

Liver Injury In Acute Fatty Liver Of Pregnancy: Possible Link To Placental Mitochondrial Dysfunction And Oxidative Stress, Sathish Kumar Natarajan, Kavitha R. Thangaraj, C. E. Eapen, Anup Ramachandran, Ashis Mukhopadhya, Mathews Mathai, Lakshmi Seshadri, Abraham Peedikayil, Banumathi Ramakrishna, Kunnissery A. Balasubramanian

Department of Nutrition and Health Sciences: Faculty Publications

Acute fatty liver of pregnancy (AFLP) is a rare disorder which is fatal if not recognized and treated early. Delivery of the feto-placental unit results in dramatic improvement in maternal liver function, suggesting a role for the placenta. However, the mechanisms by which defects in the fetus or placenta lead to maternal liver damage are not well understood and form the focus of this study. Placenta and serum were obtained at delivery from patients with AFLP, and placental mitochondria and peroxisomes were isolated. Placental mitochondrial function, oxidative stress, and fatty acid composition as well asserumantioxidants, oxidativeandnitrosative stress markers,andfatty acid analysis …

Targeted Deletion Of Hepatocyte Abca1 Leads To Very Low Density Lipoprotein Triglyceride Overproduction And Low Density Lipoprotein Hypercatabolism, Soonkyu Chung, Jenelle M. Timmins, Myngan Duong, Chiara Degirolamo, Shunxing Rong, Janet K. Sawyer, Roshni R. Singaraja, Michael R. Hayden, Nobuyo Maeda, Lawrence L. Rudel, Gregory S. Shelness, John S. Parks

Department of Nutrition and Health Sciences: Faculty Publications

Loss of ABCA1 activity in Tangier disease (TD) is associated with abnormal apoB lipoprotein (Lp) metabolism in addition to the complete absence of high density lipoprotein (HDL). We used hepatocyte-specific ABCA1 knock-out (HSKO) mice to test the hypothesis that hepatic ABCA1 plays dual roles in regulating Lp metabolism and nascent HDL formation. HSKO mice recapitulated the TD lipid phenotype with postprandial hypertriglyceridemia, markedly decreased LDL, and near absence of HDL. Triglyceride (TG) secretion was 2-fold higher in HSKO compared with wild type mice, primarily due to secretion of larger TG-enriched VLDL secondary to reduced hepatic phosphatidylinositol 3-kinase signaling. HSKO mice …

Nutrition-Related Practices And Attitudes Of Kansas Skipped-Generation(S) Caregivers And Their Grandchildren, Mary Meck Higgins, Bethany J. Murray

Department of Nutrition and Health Sciences: Faculty Publications

Despite growing numbers, the nutrition practices and attitudes of skipped-generation(s) kinship caregivers regarding feeding the dependent children in their care have not been examined. In this qualitative study, transcriptions of semi-structured interviews with 19 female and four male skipped-generation(s) Kansas caregivers (ages 47 to 80, 92% non-Hispanic whites, 83% female, 78% grandparents and 22% great-aunt or great-grandparent caregivers; caring for a range of one to four children, ages three to 18, for an average of nine years) were content analyzed for how their nutrition-related practices and attitudes had changed since parenting the first time. Sub-themes regarding practices included: being more …

Predicting Successful Aging In A Population-Based Sample Of Georgia Centenarians, Jonathan Arnold, Jianliang Dai, Lusine Nahapetyan, Ankit Arte, Mary Ann Johnson, Dorothy Hausman, Willard L. Rodgers, Robert Hensley, Peter Martin, Maurice Macdonald, Adam Davey, Ilene C. Siegler, S. Michal Jazwinski, Leonard W. Poon

Department of Nutrition and Health Sciences: Faculty Publications

Used a population-based sample (Georgia Centenarian Study, GCS), to determine proportions of centenarians reaching 100 years as (1) survivors (43%) of chronic diseases first experienced between 0–80 years of age, (2) delayers (36%) with chronic diseases first experienced between 80–98 years of age, or (3) escapers (17%) with chronic diseases only at 98 years of age or older. Diseases fall into two morbidity profiles of 11 chronic diseases; one including cardiovascular disease, cancer, anemia, and osteoporosis, and another including dementia. Centenarians at risk for cancer in their lifetime tended to be escapers (73%), while those at risk for cardiovascular disease …

Tailoring Messages To Individual Differences In Monitoring- Blunting Styles To Increase Fruit And Vegetable Intake, Pamela Williams-Piehota, Amy E. Latimer, Nicole A. Katulak, Ashley Cox, Stephanie A. Navarro Silvera, Linda Mowad, Peter Salovey

Department of Public Health Scholarship and Creative Works

Objective

To examine whether messages matched to individuals' monitoring-blunting coping styles (MBCS) are more effective in increasing fruit and vegetable intake than mismatched messages. MBCS refers to the tendency to either attend to and amplify, or distract oneself from and minimize threatening information.

Design/Setting

Randomly assigned messages were tailored to resonate with either monitors or blunters and delivered at baseline, 1 week, 2 months, and 3 months later. Surveys were conducted at baseline and 2 and 4 months later.

Participants

531 callers to a cancer information hotline who did not meet the 5 A Day guideline.

Intervention

A brief telephone-delivered …

Alteration Of The Gastrointestinal Microbiota Of Mice By Edible Blue-Green Algae, H. E. Rasmussen, I. Martínez, J. Y. Lee, J. Walter

Department of Nutrition and Health Sciences: Faculty Publications

Aims: To characterize the effect of edible blue-green algae (cyanobacteria) on the gastrointestinal microbiota of mice. Methods and Results: C57BL⁄6J mice were fed a diet supplemented with 0% or 5% dried Nostoc commune, Spirulina platensis, or Aphanizominon flos-aquae (w⁄w) for 4 weeks. Molecular fingerprinting of the colonic microbiota using denaturing gradient gel electrophoresis revealed that administration of N. commune induced major alterations in colonic microbiota composition, while administration of S. platensis or A. flos-aquae had a more subtle impact. Community profile analysis revealed that administration of N. commune did not reduce microbial diversity indices of the colonic microbiota. …

Hypocholesterolemic Effect Of Nostoc Commune Var. Sphaeroides Kützing, An Edible Blue-Green Alga, Heather E. Rasmussen, Kara R. Blobaum, Elliot D. Jesch, Chai Siah Ku, Young-Ki Park, Fan Lu, Timothy P. Carr, Ji-Young Li

Department of Nutrition and Health Sciences: Faculty Publications

Background Intake of an edible blue-green alga Nostoc commune var. sphaeroides Kützing (N. commune) has been shown to lower plasma total cholesterol concentration, but the mechanisms behind the hypocholesterolemic effect have not been elucidated. Aim of the study To elucidate the mechanisms underlying the cholesterol-lowering effect of N. commune in mice. Methods Male C57BL/6J mice were fed the AIN-93 M diet supplemented with 0 or 5% (wt/wt) dried N. commune for 4 weeks. Lipid levels in the plasma and liver, intestinal cholesterol absorption, and fecal sterol excretion were measured. Expression of hepatic and intestinal genes involved in cholesterol …

The “Babe” Vegetarians: Bioethics, Animal Minds And Moral Methodology, Nathan Nobis

Attitudes Towards Animals Collection

Here I discuss the role the film “Babe” has played in helping people address these challenges and make this moral progress. It is thought that a significant number of young people (mostly girls, now young women) became vegetarians due to their seeing “Babe.” These people are often called “Babe Vegetarians,” influence by what has been called “The Babe Effect.” Many of their stories are found on the internet.

Effects Of Β-Alanine Supplementation And High-Intensity Interval Training On Endurance Performance And Body Composition In Men; A Double-Blind Trial, Abbie E. Smith, Ashley A. Walter, Jennifer L. Graef, Kristina L. Kendall, Jordan R. Moon, Christopher M. Lockwood, David H. Fukuda, Travis W. Beck, Joel T. Cramer, Jeffrey R. Stout

Department of Nutrition and Health Sciences: Faculty Publications

Background: Intermittent bouts of high-intensity exercise result in diminished stores of energy substrates, followed by an accumulation of metabolites, promoting chronic physiological adaptations. In addition, β-alanine has been accepted has an effective physiological hydrogen ion (H⁺) buffer. Concurrent high-intensity interval training (HIIT) and β-alanine supplementation may result in greater adaptations than HIIT alone. The purpose of the current study was to evaluate the effects of combining β-alanine supplementation with high-intensity interval training (HIIT) on endurance performance and aerobic metabolism in recreationally active college-aged men.

Methods: Forty-six men (Age: 22.2 ± 2.7 yrs; Ht: 178.1 ± 7.4 cm; Wt: …

Effects Of Β-Alanine Supplementation And High-Intensity Interval Training On Endurance Performance And Body Composition In Men; A Double-Blind Trial, Abbie E. Smith, Ashley A. Walter, Jennifer L. Graef, Kristina L. Kendall, Jordan R. Moon, Christopher M. Lockwood, David H. Fukuda, Travis W. Beck, Joel T. Cramer, Jeffrey R. Stout

Department of Nutrition and Health Sciences: Faculty Publications

Background: Intermittent bouts of high-intensity exercise result in diminished stores of energy substrates, followed by an accumulation of metabolites, promoting chronic physiological adaptations. In addition, β-alanine has been accepted has an effective physiological hydrogen ion (H⁺) buffer. Concurrent high-intensity interval training (HIIT) and β-alanine supplementation may result in greater adaptations than HIIT alone. The purpose of the current study was to evaluate the effects of combining β-alanine supplementation with high-intensity interval training (HIIT) on endurance performance and aerobic metabolism in recreationally active college-aged men.

Methods: Forty-six men (Age: 22.2 ± 2.7 yrs; Ht: 178.1 ± 7.4 cm; Wt: …

Acute Effects Of A Thermogenic Nutritional Supplement On Cycling Time To Exhaustion And Muscular Strength In College-Aged Men, Ashley A. Walter, Trent J. Herda, Eric D. Ryan, Pablo B. Costa, Katherine M. Hoge, Travis W. Beck, Jeffrey R. Stout, Joel T. Cramer

Department of Nutrition and Health Sciences: Faculty Publications

Background: The purpose of the present study was to examine the acute effects of a thermogenic nutritional supplement containing caffeine, capsaicin, bioperine, and niacin on muscular strength and endurance performance.

Methods: Twenty recreationally-active men (mean ± SD age = 21.5 ± 1.4 years; stature = 178.2 ± 6.3 cm; mass = 76.5 ± 9.9 kg; VO_{2 PEAK} = 3.05 ± 0.59 L/min^-1) volunteered to participate in this randomized, double-blinded, placebo-controlled, cross-over study. All testing took place over a three-week period, with each of the 3 laboratory visits separated by 7 days (± 2 hours). During the initial …

2009- 2010 Unlv Mcnair Journal, Kathleen Bell, Danetta Bradley, Vacheral M. Carter, Nydia Diaz, Kathryn E. English, Sarah Harrison, Michelle Israel, Christina Macke, Erica Orozco, Pilar Palos, Sandra Ramos, Soraya A. Silverman, Susan Taylor, Sajar Camara, William Mccurdy, Yvonne C. Morris, Maxym V. Myroshnychenko, Ricardo Rios, Monique Sulls, Bremen Vance, Barbara Wallen

McNair Journal

Journal articles based on research conducted by undergraduate students in the McNair Scholars Program

Table of Contents

Biography of Dr. Ronald E. McNair

Statements:

Dr. Neal J. Smatresk, UNLV President

Dr. Juanita P. Fain, Vice President of Student Affairs

Dr. William W. Sullivan, Associate Vice President for Retention and Outreach

Mr. Keith Rogers, Deputy Executive Director of the Center for Academic Enrichment and Outreach

McNair Scholars Institute Staff

Initial Interaction Of Apoa-I With Abca1 Impacts In Vivo Metabolic Fate Of Nascent Hdl, Anny Mulya, Ji-Young Lee, Abraham K. Gebre, Elena Y. Boudyguina, Soonkyu Chung, Thomas L. Smith, Perry L. Colvin, Xian-Cheng Jiang, John S. Parks

Department of Nutrition and Health Sciences: Faculty Publications

We investigated the in vivo metabolic fate of preb HDL particles in human apolipoprotein A-I transgenic (hA-I Tg) mice. Pre-b HDL tracers were assembled by incubation of [125I]tyramine cellobiose-labeled apolipoprotein A-I (apoA-I) with HEK293 cells expressing ABCA1. Radiolabeled pre-b HDLs of increasing size (pre-b1, -2, -3, and -4 HDLs) were isolated by fast-protein liquid chromatography and injected into hA-I Tg-recipient mice, after which plasma decay, in vivo remodeling, and tissue uptake were monitored. Pre-b2, -3, and -4 had similar plasma die-away rates, whereas pre-b1 HDL was removed 7-fold more rapidly. Radiolabel recovered in liver and kidney 24 h after tracer …

Lipid Extract Of Nostoc Commune Var. Sphaeroides Kützing, A Blue-Green Alga, Inhibits The Activation Of Sterol Regulatory Element Binding Proteins In Hepg2 Cells, Heather E. Rasmussen, Kara R. Blobaum, Young-Ki Park, Sarah J. Ehlers, Fan Lu, Ji-Young Lee

Department of Nutrition and Health Sciences: Faculty Publications

Nostoc commune var. sphaeroides Kützing (N. commune), a blue-green alga, has been used as both a food ingredient and in medicine for centuries. To determine the effect of N. commune on cholesterol metabolism, N. commune lipid extract was incubated at increasing concentrations (25–100 mg/L) with HepG2 cells, a human hepatoma cell line. The addition of N. commune lipid extract markedly reduced mRNA abundance of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) and LDL receptor (LDLR) (P < 0.05), with a concomitant decrease in their protein expression (P < 0.001). Reduced HMGR activity by 90% with N. commune lipid extract confirmed the inhibitory role of N. commune in cholesterol synthesis (P < 0.006). To elucidate a molecular mechanism underlying the repression of HMGR and LDLR by N. commune lipid extract, expression of sterol regulatory …

Effects Of A Supplement Designed To Increase Atp Levels On Muscle Strength, Power Output, And Endurance, Trent J. Herda, Eric D. Ryan, Jeffrey R. Stout, Joel T. Cramer

Department of Nutrition and Health Sciences: Faculty Publications

Background: The present study examined the acute effects of a nutritional supplement intended to improve adenosine triphosphate (ATP) concentrations on vertical jump height, isometric strength of the leg extensors, leg extension endurance, and forearm flexion endurance.

Methods: Twenty-four healthy men (mean age ± SD = 23 ± 4 yrs, stature = 181 ± 7 cm, and body mass = 82 ± 12 kg) volunteered to complete a familiarization trial plus 2 randomly-ordered experimental trials separated by a 7-day washout period. Participants received either 6 (body mass < 91 kg) or 8 (body mass ≥ 91 kg) tablets of the treatment (TR; 625 mg of adenylpyrophosphoric acid and calcium pyruvate, 350.8 mg of cordyceps sinensis extract and yohimbine hydrochloride) or placebo (PL; 980 mg of microcrystalline cellulose) 1 hour prior to the following tests: countermovement vertical jump (CVJ), forearm flexion repetitions to exhaustion, isometric maximal voluntary contractions (MVCs) of the leg extensors, and a 50-repetition maximal concentric isokinetic leg extension endurance test.

Results: There were no differences between the TR and PL trials for CVJ height …

The Effect Of Beta-Alanine Supplementation On Neuromuscular Fatigue In Elderly (55–92 Years): A Double-Blind Randomized Study, Jeffrey R. Stout, B. Sue Graves, Abbie E. Smith, Michael J. Hartman, Joel T. Cramer, Travis W. Beck, Roger C. Harris

Department of Nutrition and Health Sciences: Faculty Publications

Background: Ageing is associated with a significant reduction in skeletal muscle carnosine which has been linked with a reduction in the buffering capacity of muscle and in theory, may increase the rate of fatigue during exercise. Supplementing beta-alanine has been shown to significantly increase skeletal muscle carnosine. The purpose of this study, therefore, was to examine the effects of ninety days of beta-alanine supplementation on the physical working capacity at the fatigue threshold (PWC_FT) in elderly men and women.

Methods: Using a double-blind placebo controlled design, twenty-six men (n = 9) and women (n = 17) (age ± …

Inhibition Of Stearoyl-Coa Desaturase 1 (Scd1) Dissociates Insulin Resistance And Obesity From Atherosclerosis, J. Mark Brown, Soonkyu Chung, Janet K. Sawyer, Chiara Degirolamo, Heather M. Alger, Tam Nguyen, Xuewei Zhu, My-Ngan Duong, Amanda L. Wibley, Ramesh Shah, Matthew A. Davis, Kathryn Kelley, Martha D. Wilson, Carol Kent, John S. Parks, Lawrence L. Rudel

Department of Nutrition and Health Sciences: Faculty Publications

Background—Stearoyl-CoA Desaturase 1 (SCD1) is a well-known enhancer of the metabolic syndrome. The purpose of the present study was to investigate the role of SCD1 in lipoprotein metabolism and atherosclerosis progression.

Methods and Results—Antisense oligonucleotides were used to inhibit SCD1 in a mouse model of hyperlipidemia and atherosclerosis (LDLr^-/-Apob^100/100). In agreement with previous reports, inhibition of SCD1 protected against diet-induced obesity, insulin resistance, and hepatic steatosis. However, unexpectedly SCD1 inhibition strongly promoted aortic atherosclerosis, which could not be reversed by dietary oleate. Further analyses revealed that SCD1 inhibition promoted accumulation of saturated fatty acids …

Total Body Water Estimations In Healthy Men And Women Using Bioimpedance Spectroscopy: A Deuterium Oxide Comparison, Jordan R. Moon, Sarah E. Tobkin, Michael D. Roberts, Vincent J. Dalbo, Chad M. Kerksick, Michael G. Bemben, Joel T. Cramer, Jeffrey R. Stout

Department of Nutrition and Health Sciences: Faculty Publications

Background: Total body water (TBW) estimations have been used to estimate body composition, particularly fat-free mass, to aid in nutritional interventions, and to monitor hydration status. In the past, bioimpedance spectroscopy (BIS) devices have been used to estimate TBW. Previous investigations have examined the validity of the XiTRON 4000B (XiTRON Technologies) BIS device for estimating TBW. Recently, a new BIS device (Imp™ SFB7) has become available, claiming greater precision when estimating TBW. The Imp™ SFB7 (SFB7) is based on similar BIS principles, while offering increased portability and a greater range of frequencies when compared to older devices, such as the …

Minimal Nutrition Intervention With High-Protein/Low-Carbohydrate And Low-Fat, Nutrient-Dense Food Supplement Improves Body Composition And Exercise Benefits In Overweight Adults: A Randomized Controlled Trial, Christopher M. Lockwood, Jordan R. Moon, Sarah E. Tobkin, Ashley A. Walter, Abbie E. Smith, Vincent J. Dalbo, Joel T. Cramer, Jeffrey R. Stout

Department of Nutrition and Health Sciences: Faculty Publications

Background: Exercise and high-protein/reduced-carbohydrate and -fat diets have each been shown separately, or in combination with an energy-restricted diet to improve body composition and health in sedentary, overweight (BMI > 25) adults. The current study, instead, examined the physiological response to 10 weeks of combined aerobic and resistance exercise (EX) versus exercise + minimal nutrition intervention designed to alter the macronutrient profile, in the absence of energy restriction, using a commercially available high-protein/low-carbohydrate and low-fat, nutrient-dense food supplement (EXFS); versus control (CON).

Methods: Thirty-eight previously sedentary, overweight subjects (female = 19; male = 19) were randomly assigned to either CON (n …

Pre-Workout Consumption Of Celsius® Enhances The Benefits Of Chronic Exercise On Body Composition And Cardiorespiratory Fitness, Jeffrey R. Stout, Jordan R. Moon, Sarah E. Tobkin, Christopher M. Lockwood, Abbie E. Smith, Jennifer L. Graef, Kristina L. Kendall, Travis W. Beck, Joel T. Cramer

Department of Nutrition and Health Sciences: Faculty Publications

The functional beverage Celsius®, has recently been shown, after acute and chronic (28 days) consumption, to increase resting metabolism and serum blood markers of lipolysis in healthy, college-aged men and women. The purpose of this study was to examine the combined effects of a 10-week exercise program while consuming Celsius® on body composition and cardiorespiratory fitness changes in sedentary men and women.