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Articles 2041 - 2070 of 3876

Full-Text Articles in Exercise Science

Effective Treatment Of An Apparent Lateral Ankle Sprain Using A Regional Interdependent Approach With Positional Release Therapy And Mulligan Concept, Joshua K. Underwood Mar 2020

Effective Treatment Of An Apparent Lateral Ankle Sprain Using A Regional Interdependent Approach With Positional Release Therapy And Mulligan Concept, Joshua K. Underwood

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Objective: Present a pair of clinical cases demonstrating the utilization of regional interdependent (RI) evaluation and treatment in an apparent lateral ankle sprain. The utilization of both Positional Release Therapy (PRT) and Mulligan Concept (MC) on secondary school athletes with an apparent acute lateral ankle sprain are presented. Background: Lateral ankle sprains are a common injury in athletics. While the MC has been shown to be an effective manual therapy in ankle sprains, if the treatment is not pain-free it is considered not warranted. The concept of RI attempts to connect apparently unconnected dysfunctions within the body which collectively contribute …


Student Athlete Perceptions Of Athletic Trainers’ Competence Based On Appearance And Dress, Jennifer J. Rogers Mar 2020

Student Athlete Perceptions Of Athletic Trainers’ Competence Based On Appearance And Dress, Jennifer J. Rogers

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Context: Physical appearance and dress attire may be a major influence on a person’s perception of an individual’s professional competence. Objective: To examine influence of Athletic Trainer (AT) physical appearance and dress attire on student-athletes’ perception of an AT’s competence. Design: Cross-Sectional Study Setting: NATA District 5 Participants: Student athletes (n=156; female: n=71; male: n=78) from NCAA Division III and NAIA institutions participated in the study. Interventions: Participants viewed one of four Body Mass Index (BMI) specific AT images [underweight BMI=18, normal weight BMI=24, overweight BMI=30, or an obese BMI=36] while answering 36 Student Athlete Response (SAR) Form survey questions …


The Effectiveness Of An Infrapatellar Strap On Reducing Pain Associated With Patellar Tendinopathy, Jenny Toonstra, Andrea Cripps Mar 2020

The Effectiveness Of An Infrapatellar Strap On Reducing Pain Associated With Patellar Tendinopathy, Jenny Toonstra, Andrea Cripps

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Purpose: To determine the effectiveness of an infrapatellar strap on pain reduction in participants with patellar tendinopathy. Methods: Articles were identified from PubMed, CINAHL, Medline, and SportDiscus using the string “((((patellar tendinitis OR patellar tendinopathy))) AND ((cho-pat strap OR infrapatellar strap OR compression device OR brace))) AND pain” from January 2009-January 2019, resulting in nine studies. After a review of the title and abstracts, six studies were reviewed in-depth. Of these articles, four studies met the inclusion criteria. Two independent reviewers assessed the level of evidence of included studies using the Oxford Center for Evidence-Based Medicine (2009). Changes in pain …


Comparisons Of Muscle Strength, Size, And Neuromuscular Function In Pre- And Post-Pubescent Males And Females, Zachary M. Gillen Mar 2020

Comparisons Of Muscle Strength, Size, And Neuromuscular Function In Pre- And Post-Pubescent Males And Females, Zachary M. Gillen

College of Education and Human Sciences: Dissertations, Theses, and Student Research

The purpose of this study was to compare measurements of muscle strength, size, and neuromuscular function of the forearm flexors in pre- and post-pubescent males and females. Forty pre-pubescent (mean ± 95% confidence interval, age = 9.79 ± 0.35 yrs, n = 10 males, n = 10 females) and post-pubescent (age = 17.23 ± 0.58 yrs, n = 10 males, n = 10 females) participants completed this study. Biceps brachii muscle cross-sectional area (CSA) and muscle volume (MV) were quantified from ultrasound images. Participants completed maximal voluntary isometric contractions (MVICs) of the forearm flexors and extensors, and submaximal isometric step …


A 24 Hour Naproxen Dose On Gastrointestinal Distress And Performance During Cycling In The Heat, Dawn M. Emerson, J Mark Davis, Stephen Cl Chen, Toni M. Torres-Mcgehee, Craig E. Pfeifer, Charles C. Emerson, Joseph D. Bivona, Justin V. Stone Mar 2020

A 24 Hour Naproxen Dose On Gastrointestinal Distress And Performance During Cycling In The Heat, Dawn M. Emerson, J Mark Davis, Stephen Cl Chen, Toni M. Torres-Mcgehee, Craig E. Pfeifer, Charles C. Emerson, Joseph D. Bivona, Justin V. Stone

Faculty Publications

Using a double-blind, randomized and counterbalanced, cross-over design, we assessed naproxen's effects on gastrointestinal (GI) distress and performance in eleven volunteers (6 male, 5 female). Participants completed 4 trials: 1) placebo and ambient); 2) placebo and heat; 3) naproxen and ambient; and 4) naproxen and heat. Independent variables were one placebo or 220 mg naproxen pill every 8 h (h) for 24 h and ambient (22.7 ± 1.8°C) or thermal environment (35.7 ± 1.3°C). Participants cycled 80 min at a steady heart rate then 10 min for maximum distance. Perceived exertion was measured throughout cycling. Gastrointestinal distress was assessed pre-, …


The Basics Of Training For Muscle Size And Strength: A Brief Review On The Theory, Samuel L. Buckner, Matthew B. Jessee, Grant J. Mouser, Scott J. Dankel, Kevin T. Mattocks, Zachary W. Bell, Takashi Abe, Jeremy P. Loenneke Mar 2020

The Basics Of Training For Muscle Size And Strength: A Brief Review On The Theory, Samuel L. Buckner, Matthew B. Jessee, Grant J. Mouser, Scott J. Dankel, Kevin T. Mattocks, Zachary W. Bell, Takashi Abe, Jeremy P. Loenneke

Faculty Scholarship

The periodization of resistance exercise is often touted as the most effective strategy for optimizing muscle size and strength adaptations. This narrative persists despite a lack of experimental evidence to demonstrate its superiority. In addition, the general adaptation syndrome, which provides the theoretical framework underlying periodization, does not appear to provide a strong physiological rationale that periodization is necessary. Hans Selye conducted a series of rodent studies which used toxic stressors to facilitate the development of the general adaptation syndrome. To our knowledge, normal exercise in humans has never been shown to produce a general adaptation syndrome. We question whether …


Examining Group Differences In Emotion Regulation Strategies And The State And Trait Anxiety Of Lifeguards And Non-Lifeguards In A Real-World Precompetitive Situation, Hannah Calverley, Dr Paul Davis, Dr Jack Harvey, Dr Christopher Mesagno Feb 2020

Examining Group Differences In Emotion Regulation Strategies And The State And Trait Anxiety Of Lifeguards And Non-Lifeguards In A Real-World Precompetitive Situation, Hannah Calverley, Dr Paul Davis, Dr Jack Harvey, Dr Christopher Mesagno

International Journal of Aquatic Research and Education

The purpose of this study was to investigate differences, between swimmer-lifeguards and swimmer-non-lifeguards, in trait and state anxiety and emotion regulation techniques in a real-life precompetitive situation with a secondary focus on gender differences. The Emotion Regulation Questionnaire, Sport Anxiety Scale – 2 and the Mental Readiness Form – 3 were distributed to 100 participants at university swimming competitions in the United Kingdom. Swimmer-lifeguards displayed significantly lower cognitive (p=.03) and somatic state (p=.05) anxiety and cognitive trait anxiety (p=.02) than swimmer-non-lifeguards. Males reported significantly lower levels of cognitive and somatic trait anxiety (ppp=.01); no …


Temporal Trends In The Standing Broad Jump Performance Of United States Children And Adolescents, Bridget K. Pinoniemi, Grant R. Tomkinson, Tanis J. Walch, James N. Roemmich, John S. Fitzgerald Feb 2020

Temporal Trends In The Standing Broad Jump Performance Of United States Children And Adolescents, Bridget K. Pinoniemi, Grant R. Tomkinson, Tanis J. Walch, James N. Roemmich, John S. Fitzgerald

Education, Health & Behavior Studies Faculty Publications

Purpose: To estimate temporal trends in broad jump performance for United States youth, a marker of muscular fitness and health.

Method: Electronic databases, topical systematic reviews, and personal libraries were systematically searched for studies reporting descriptive standing broad jump data for apparently healthy United States youth (age 10–17 years). Temporal trends at the sex-age level were estimated using sample-weighted regression models associating the year of testing to mean jump performance, with national trends standardized to the year 1985 using a post-stratified population-weighting procedure.

Results: Collectively, there was a small increase of 12.6 cm (95%CI: 12.5 to 12.7) or 7.9% (95%CI: …


Developing A Research Agenda In Applied Exercise Science, Kenneth P. Clark Feb 2020

Developing A Research Agenda In Applied Exercise Science, Kenneth P. Clark

Kinesiology Faculty Publications

No abstract provided.


Exercise In Thermal Inversions: Pm2.5 Air Pollution Effects On Pulmonary Function And Aerobic Performance, Dale R. Wagner, Daniel C. Brandley Feb 2020

Exercise In Thermal Inversions: Pm2.5 Air Pollution Effects On Pulmonary Function And Aerobic Performance, Dale R. Wagner, Daniel C. Brandley

Kinesiology and Health Science Faculty Publications

Introduction Wintertime thermal inversions can lead to the accumulation of small particulate matter (PM2.5). Despite an association between respiratory hospital admissions and elevated PM2.5 levels, many people continue to exercise outdoors during inversions. This study compared pulmonary function and exercise performance during periods of low and high ambient PM2.5 concentrations. Methods Forced vital capacity and forced expiratory volume in 1 s were measured outdoors before and after two 3200 m running time trials: one with low ambient PM2.5 (0.6–14.7 microgram·m-3), and the other during high PM2.5 (19.1–42.5 micrograms·m-3). A 10 …


Practitioner Perceptions Regarding The Practices Of Soccer Substitutes, Samuel P. Hills, Jon N. Radcliffe, Martin J. Barwood, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Carlton B. Cooke, Mark Russell Feb 2020

Practitioner Perceptions Regarding The Practices Of Soccer Substitutes, Samuel P. Hills, Jon N. Radcliffe, Martin J. Barwood, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Carlton B. Cooke, Mark Russell

Faculty Publications

Despite empirical observations suggesting that practitioners value the use of substitutions during soccer match-play, limited research has sought to substantiate such claims. This study used online surveys to assess the perceptions of practitioners within professional soccer about the use and practices of substitutes. Thirty-three practitioners completed one of two surveys (each requiring both open and closed questions to be answered), depending upon whether their primary role related mostly to tactical (‘tactical practitioners’; n = 7) or physical (‘physical practitioners’; n = 26) aspects of player/team management. Thematic content analysis of responses identified four higher-order themes: ‘impact of substitutions’, ‘planning and …


Limb Occlusion Pressure: A Method To Assess Changes In Systolic Blood Pressure, Zachary W. Bell, Matthew B. Jessee, Kevin T. Mattocks, Samuel L. Buckner, Scott J. Dankel, J. Grant Mouser, Takashi Abe, Jeremy P. Loenneke Feb 2020

Limb Occlusion Pressure: A Method To Assess Changes In Systolic Blood Pressure, Zachary W. Bell, Matthew B. Jessee, Kevin T. Mattocks, Samuel L. Buckner, Scott J. Dankel, J. Grant Mouser, Takashi Abe, Jeremy P. Loenneke

Faculty Scholarship

Although often used as a surrogate, comparisons between traditional blood pressure measurements and limb occlusion assessed via hand-held Doppler have yet to be completed. Using limb occlusion pressure as a method of assessing systolic pressure is of interest to those studying the acute effects of blood flow restriction, where the removal of the cuff may alter the physiological response. Purpose: We sought to determine how changes in limb occlusion pressure track with changes in traditional assessments of blood pressure. Basic Procedures: Limb occlusion pressure measured by hand-held Doppler and blood pressure measured by an automatic blood pressure cuff were assessed …


Approaches To Teaching In Kinesiology, Bryan L. Haddock Jan 2020

Approaches To Teaching In Kinesiology, Bryan L. Haddock

Q2S Enhancing Pedagogy

This is a syllabus for a new class in the semester system for the Kinesiology department. The syllabus is for KINE 4700, Clinical Exercise Physiology. This course upper division course will review common clinical diseases, disorders, and conditions. Students will review the epidemiology, physiology, and pathophysiology of these conditions. Students will participate in active learning activities, such as the development of videos, in which students will demonstrate and explain how different exercise movements will be utilized. The course will follow an outline derived from information gained in the textbook from the world’s premier sports medicine organization, The American College of …


Early-Morning And Late-Night Maximal Runs: Metabolic And Perceived Exertion Outcomes, Jenna L. Carducci, Matthew J. Garver, Whitley J. Stone, Meera Penumetcha, Dustin W. Davis, Nicolas M. Philipp, Josie N. Hair Jan 2020

Early-Morning And Late-Night Maximal Runs: Metabolic And Perceived Exertion Outcomes, Jenna L. Carducci, Matthew J. Garver, Whitley J. Stone, Meera Penumetcha, Dustin W. Davis, Nicolas M. Philipp, Josie N. Hair

Topics in Exercise Science and Kinesiology

  • People may exercise at the ends of their day to fit activity into their schedule; the purpose of this investigation was to determine if metabolic or perceived exertion outcomes differed between maximal runs early in the morning and late at night.
  • After consuming a standardized, glucose drink, thirteen recreationally active individuals completed an early-morning and a late-night run on the treadmill while researchers measured metabolic (aerobic capacity and substrate usage) and perceived exertion outcomes.
  • Point of application #1: Aerobic capacity (maximal consumption of oxygen) and the usage of fat as a fuel to support energy production during exercise were …


Guidelines For Reviewers: Topics In Exercise Science And Kinesiology, James W. Navalta, Donald L. Hoover, Robert Salatto, Whitley J. Stone, Scott Lyons Phd Jan 2020

Guidelines For Reviewers: Topics In Exercise Science And Kinesiology, James W. Navalta, Donald L. Hoover, Robert Salatto, Whitley J. Stone, Scott Lyons Phd

Topics in Exercise Science and Kinesiology

  • The purpose of this document is to serve as a guide for evaluators who agree to review work submitted to Topics in Exercise Science and Kinesiology.
  • To assist evaluators, a Reviewer Rubric has been created with the following sections: Title Page and Abstract, Introduction and Methods Page, Point of Application Page(s), Other Considerations, and Reviewer Decisions.
  • Point of application: Reviewing the Title and Abstract page – rubric shared for title, author list, affiliations, the abstract, and key words.
  • Point of application: Reviewing the Introduction and Methods page – evaluation of introductory paragraph, paragraph for methodology and/or results.
  • Point of …


Ground Contact Time Imbalances Strongly Related To Impaired Running Economy, Dustin P. Joubert, Nicholas A. Guerra, Eric J. Jones, Erica G. Knowles, Aaron D. Piper Jan 2020

Ground Contact Time Imbalances Strongly Related To Impaired Running Economy, Dustin P. Joubert, Nicholas A. Guerra, Eric J. Jones, Erica G. Knowles, Aaron D. Piper

Faculty Publications

Running economy (RE) is defined as the oxygen consumption (VO2) or caloric unit cost required to move at a specific velocity and is an important performance marker. Ground contact time (GCT) has been associated with RE; however, it has not been established how GCT imbalances between feet impact RE. Purpose: Determine the relationship between cadence, GCT, and GCT imbalances and RE. Methods: 11 NCAA Division I distance runners (7 male) completed a graded exercise test on a treadmill to determine lactate threshold (LT) and VO2max. Body composition was also assessed via DEXA. Subjects ran with a heart rate monitor capable …


Comparison Of Post-Activation Potentiating Stimuli On Jump And Sprint Performance, Aaron D. Piper, Dustin P. Joubert, Eric J. Jones, Malcom T. Whitehead Jan 2020

Comparison Of Post-Activation Potentiating Stimuli On Jump And Sprint Performance, Aaron D. Piper, Dustin P. Joubert, Eric J. Jones, Malcom T. Whitehead

Faculty Publications

Post-activation potentiation (PAP) is a phenomenon characterized by improved muscle performance based on the previous contractile activity of the muscle. The purpose of this study was to determine the effect of different potentiating stimuli on jump and sprint performance in 13 resistance trained, college-aged men and women. After determining back squat 1 repetition max, subjects returned for testing on separate days to complete one of four interventions (dynamic resistance, weighted plyometric, isometric, or control) in a randomized order. A standardized warmup was performed, followed by a baseline countermovement jump (CMJ) and 20m sprint. Following warm-up and baseline measurements, subjects performed …


How Exercise Impacts The Brain And Cognition, Cody Larson Jan 2020

How Exercise Impacts The Brain And Cognition, Cody Larson

Biology and Microbiology Graduate Students Plan B Research Projects

Physical exercise has been shown to impact the brains composition and functionality. The changes that arise in the structure of brain, as result of engaging in physical exercise, give rise to cognitive changes. Structural changes are observed most notably in the prefrontal cortex and hippocampus. These changes are preceded by elevations in cerebral blood flow, and growth factors, resulting increased neuroplasticity and neurogenesis. Frequency, duration, intensity, and type of physical exercise can have differing effects on the brain. Moderate intensity aerobic exercise presents the most profound improvements in memory, and inhibitory control over time.


Heart Rate And Rating Of Perceived Exertion During High-Intensity Interval Training: Implications For Prescribing Intensity, Emily R. Dunston, Alan Coelho, Katie Taylor Jan 2020

Heart Rate And Rating Of Perceived Exertion During High-Intensity Interval Training: Implications For Prescribing Intensity, Emily R. Dunston, Alan Coelho, Katie Taylor

2020 Symposium Posters

High-intensity interval training (HIIT) is a popular and effective time-efficient alternative to moderate-intensity continuous training for improving cardiorespiratory fitness. However, there is limited research investigating the most effective and practical way to prescribe training intensities for HIIT. PURPOSE: To determine heart rate (HR) and rating of perceived exertion (RPE) responses across a bout of HIIT. Additionally, the relationship between HR and RPE was examined. METHODS: Young adults (n=16; age 21.8±1.4 years; 10 females) visited the lab on two separate occasions. At the first visit, participants completed an incremental exercise test on a cycle ergometer to determine peak power output (PPO). …


Affective Response To Upper Body And Lower Body Exercise, Shanelle J. Osorio Jan 2020

Affective Response To Upper Body And Lower Body Exercise, Shanelle J. Osorio

Honors Undergraduate Theses

More than one-half of university students in the United States and Canada are not active enough to gain health benefits. Enjoyment of exercise proposes a feasible solution to the absence of motivation surrounding physical activity. The purpose of this study is to compare the differences in reported enjoyment between upper and lower body cycling graded exercise to exhaustion (GXT). Seven university students (23 ± 3 years old; 26 ± 4 kg/m2) performed two randomized graded exercise tests on different days: one for upper body, one for lower body. Feeling Scale (FS) measured the affective response during exercise. Post-exercise enjoyment values …


Determining Risk Factors For Neck Pain Development Due To Smartphone Use Using The Pain Pressure Threshold Test, Sally Barnes Jan 2020

Determining Risk Factors For Neck Pain Development Due To Smartphone Use Using The Pain Pressure Threshold Test, Sally Barnes

2020 Honors Symposium

BACKGROUND
• Smartphone use has become increasingly popular recently, especially in the young adult population.
• Neck flexion, the most common position when using a smartphone, has previously been linked to neck pain development.

RESEARCH QUESTION:
• Is thirty minutes of smartphone use linked to neck pain development?


Determining Muscle Fatigue From Reading A Smartphone With The Cervical Extensor Fatigue Test, Sarah Davis Jan 2020

Determining Muscle Fatigue From Reading A Smartphone With The Cervical Extensor Fatigue Test, Sarah Davis

2020 Honors Symposium

Background
• Smartphone use has led to pain and injuries associated with neck flexion while looking down.
• It is important to identify exactly how neck flexion during smartphone use leads to neck pain and muscle fatigue.

Purpose
• To measure the effects of neck flexion on neck endurance during smartphone use.


Effects Of Asthma On Lung Function, Aerobic Fitness, And Physical Activity In Young Adults, Trey Deal Jan 2020

Effects Of Asthma On Lung Function, Aerobic Fitness, And Physical Activity In Young Adults, Trey Deal

2020 Honors Symposium

INTRODUCTION
• Asthma is one of the most commonly diagnosed conditions in the United States, affecting 25 million individuals
• 90% of individuals with asthma will experience exercise-induced bronchoconstriction while performing physical activity (AAFA, 2015)
• In one study, 70% of the participants in the asthma group were classified as “predominantly sedentary” (Hul et al., 2016)
• In one survey, 20% of parents of children with asthma stated they believed exercise is dangerous for their child (Lang, Butz, Duggan, and Serwint, 2004)

OBJECTIVES
• To determine if physical activity differs between those with or without asthma
• To determine if …


The Relationship Between Glucose Levels And Physical Activity, Rebecca Eberle Jan 2020

The Relationship Between Glucose Levels And Physical Activity, Rebecca Eberle

2020 Honors Symposium

INTRODUCTION
• Elevated glucose levels can increase the risk for disease
• Physical activity behaviors are associated with glucose levels
• Limited research on young adults and their glucose levels compared to activity

OBJECTIVES
• To complete a cross sectional study and determine associations between fasting glucose with physical activity, and fitness


Hunger Regulation Before And After A Bout Of Exercise, Lindsay Spitaletto Jan 2020

Hunger Regulation Before And After A Bout Of Exercise, Lindsay Spitaletto

2020 Honors Symposium

INTRODUCTION
• Obesity is an epidemic in the United States (Kim, et. al., 2016).
• Research suggests exercise aids in preventing risk factors that lead to obesity (Cercato, Fonseca, 2019 and Blundell, et. al., 2015).
• Exercise affects appetite regulation, but few studies have explored the effect of exercise on energy intake (Schoeller, et. Al, 1997).

OBJECTIVES
•Compare appetite level changes pre-and post-exercise bout using a Visual Analog Scale (VAS)
•Compare energy intake (food consumption) pre-and post-exercise bout using two 24hour food recalls


El Baloncesto Es Vida: A Look Into Strength And Conditioning, Physical Therapy, And Coaching During My Internship Abroad, Jessica Doublesin Jan 2020

El Baloncesto Es Vida: A Look Into Strength And Conditioning, Physical Therapy, And Coaching During My Internship Abroad, Jessica Doublesin

2020 Honors Symposium

An experience abroad can help a person grow in confidence and knowledge and allow them to immerse themselves in a new culture. During my time in Valencia, Spain, I was able to work at a youth basketball club, CB L’Horta Godella, alongside the club’s strength and conditioning coaches and the physical therapist and be a coach for the young athletes. The fact that I lived with a Spanish family and had an open mindset towards making friends and exploring new things allowed me to grow closer to the culture in Spain. By using my knowledge and passion for sports and …


Energy Compensation With Exercise Is Not Dependent On Dose, H. Michael Hays Jan 2020

Energy Compensation With Exercise Is Not Dependent On Dose, H. Michael Hays

Theses and Dissertations--Nutrition and Food Systems

Background: Exercise induced weight loss is often less than expected due to a coordinated set of compensatory mechanisms that serve to maintain energy homeostasis. The extent to which exercise frequency, duration, intensity and exercise energy expenditure (ExEE) influences the compensatory response to an exercise-induced energy deficit (energy compensation) is controversial. Determining how these variables impact energy compensation would help health care providers prescribe exercise with greater probability of creating a sustained negative energy balance and subsequent weight loss.

Methods: 44 Overweight/obese men and women (BMI=25-35kg/m²) aged 18 to 40 years were randomized to perform aerobic exercise 2 or 6 days/week …


The Impact Of Exercise In Spaceflight And Microgravity Environments, William Bybee Jan 2020

The Impact Of Exercise In Spaceflight And Microgravity Environments, William Bybee

Mahurin Honors College Capstone Experience/Thesis Projects

Since mankind’s first spaceflight, a significant barricade in reaching distant planets has been the damaging effects of microgravity upon the human body. Effects range from loss in bone mineral density and severe muscle atrophy to autoimmune disorders. The most effective countermeasure of these effects to date is exercise. Implementation of exercise in microgravity is not an easy task, so various specialized equipment must be utilized to effectively administer it. Even with this equipment, exercise as it is currently used does not entirely prevent body systems from undergoing detrimental changes. New modalities and implementations are currently being investigated that may significantly …


The Role Of Mitochondrial Pyruvate Carrier 1 (Mpc1) In Heart Failure And Its Implications For Cardiac Recovery, Obadiah Issachar Kirk Jan 2020

The Role Of Mitochondrial Pyruvate Carrier 1 (Mpc1) In Heart Failure And Its Implications For Cardiac Recovery, Obadiah Issachar Kirk

Mahurin Honors College Capstone Experience/Thesis Projects

Heart failure (HF) is a complex syndrome with high mortality rates around the world. HF also has diverse etiology as many things contribute such as hypertension, obesity, coronary artery disease, inflammation, and cardiac arrhythmias. Studies have shown that unloading of a failing heart with a left ventricular assist device (LVAD) can lead to cardiac recovery in a subpopulation of individuals with advanced HF. RNA-sequencing and protein expression analysis of myocardial tissue from HF patients who underwent the LVAD implant and heart transplant indicated that subpopulation of HF patients who responded to LVAD unloading had significantly lower levels of mitochondrial pyruvate …


Vitamin D3 Supplementation And Stress Fractures In High-Risk Collegiate Athletes - A Pilot Study, Kevin Williams, Christian Askew, Christopher Mazoue, Jeffrey Guy, Toni M. Torres-Mcgehee, J Benjamin Jackson Iii Jan 2020

Vitamin D3 Supplementation And Stress Fractures In High-Risk Collegiate Athletes - A Pilot Study, Kevin Williams, Christian Askew, Christopher Mazoue, Jeffrey Guy, Toni M. Torres-Mcgehee, J Benjamin Jackson Iii

Faculty Publications

INTRODUCTION: Vitamin D is paramount to bone health and little is known about vitamin D's role in the prevention of stress fractures in high-risk athletes. This study consists of a prospective, cross-sectional analysis accompanied by a retrospective review for control comparison of vitamin D3 supplementation in high-risk athletes. Our hypothesis is that supplemental vitamin D3 treatment will decrease the occurrence of stress fractures in high-risk collegiate athletes. MATERIALS AND METHODS: A total of 118 NCAA Division I athletes were recruited from 6 high-risk collegiate teams. Blood draws in August and February established baseline 25(OH)D levels. Subjects with serum 25(OH)D <30 ng/mL were supplemented with 50,000 IU of vitamin D3/week for 8 weeks. Treated subjects were re-tested to ensure serum 25(OH)D levels rose to sufficient status. All enrolled subjects were monitored for the development of stress fractures. A 5-year retrospective chart review of athletes from the same sports teams was conducted to determine the incidence of any reported stress fractures in the past. RESULTS: Prospective: 112 of the 118 enrolled subjects were tested in August. Sixty-one demonstrated vitamin D sufficiency (40.2 ng/mL ±8.28) and 51 were either insufficient or deficient (22.7 ng/mL ±4.89). Of the 118 enrolled subjects, 104 were tested in February. Fifty-six demonstrated vitamin D sufficiency (40.7 ng/mL ±9.47) and 48 were insufficient or deficient (21.6 ng/mL ±5.87). Two stress fractures were diagnosed amongst our cohort of 118 student athletes (1.69%). Retrospective: 34 stress fractures were diagnosed in 453 subjects from 01/2010-05/2015 (7.51%). Amongst our athletic teams, the cross-country team specifically demonstrated a statistically significant decrease in stress fracture incidence (p<0.05). We also found a statistically significant reduction in stress fracture incidence amongst the current overall cohort compared to our retrospective cohort (p<0.05). CONCLUSION: In our population, almost half of the tested athletes proved to be vitamin D deficient. Hypovitaminosis D was prevalent throughout the winter months compared with the summer. With vitamin D3 supplementation, the stress fracture rate in our overall cohort demonstrated a statistically significant decrease from 7.51% to 1.65% (p=0.009).