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Articles 10231 - 10260 of 13843
Full-Text Articles in Operations Research, Systems Engineering and Industrial Engineering
Digital Holographic Imaging Of Aerosol Particles In Flight, Matthew J. Berg, Gorden Videen
Digital Holographic Imaging Of Aerosol Particles In Flight, Matthew J. Berg, Gorden Videen
United States Army: Publications
This work describes the design and application of an apparatus to image aerosol
particles using digital holography in a flow-through, contact-free manner. Particles in an aerosol stream are illuminated by a triggered, pulsed laser and the pattern produced by the interference of this light with that scattered by the particles is recorded by a digital camera. The recorded pattern constitutes a digital hologram from which an image of the particles is computationally reconstructed using a fast Fourier transform. This imaging is validated using a cluster of ragweed pollen particles. Examples involving mineral-dust aerosols demonstrate the technique’s in situ imaging capability …
Application Of Hyperspectral Vegetation Indices To Detect Variations In High Leaf Area Index Temperate Shrub Thicket Canopies, Steven T. Brantley, Julie C. Zinnert, Donald R. Young
Application Of Hyperspectral Vegetation Indices To Detect Variations In High Leaf Area Index Temperate Shrub Thicket Canopies, Steven T. Brantley, Julie C. Zinnert, Donald R. Young
United States Army: Publications
Accurate measurement of leaf area index (LAI), an important characteristic of plant canopies directly linked to primary production, is essential for monitoring changes in ecosystem C stocks and other ecosystem level fluxes. Direct measurement of LAI is labor intensive, impractical at large scales and does not capture seasonal or annual variations in canopy biomass. The need to monitor canopy related fluxes across landscapes makes remote sensing an attractive technique for estimating LAI. Many vegetation indices, such as Normalized Difference Vegetation Index (NDVI), tend to saturate at LAI levels >4 although tropical and temperate forested ecosystems often exceed that threshold. Using …
Purification Of A Recombinant Heavy Chain Fragment C Vaccine Candidate Against Botulinum Serotype C Neurotoxin [Rbontc(HC)] Expressed In Pichia Pastoris, Michael P. Dux, Jicai Huang, Rick Barent, Mehmet Inan, S. Todd Swanson, Jayanta Sinha, John T. Ross, Leonard A. Smith, Theresa J. Smith, Ian Henderson, Michael M. Meagher
Purification Of A Recombinant Heavy Chain Fragment C Vaccine Candidate Against Botulinum Serotype C Neurotoxin [Rbontc(HC)] Expressed In Pichia Pastoris, Michael P. Dux, Jicai Huang, Rick Barent, Mehmet Inan, S. Todd Swanson, Jayanta Sinha, John T. Ross, Leonard A. Smith, Theresa J. Smith, Ian Henderson, Michael M. Meagher
United States Army: Publications
A purification process for the manufacture of a recombinant C-terminus heavy chain fragment from botulinum neurotoxin serotype C [rBoNTC(Hc)], a potential vaccine candidate, has been defined and successfully scaled-up. The rBoNTC(Hc) was produced intracellularly in Pichia pastoris X-33 using a three step fermentation process, i.e., glycerol batch phase, a glycerol fed-batch phase to achieve high cell densities, followed by a methanol induction phase. The rBoNTC(Hc) was captured from the soluble protein fraction of cell lysate using hydrophobic charge induction chromatography (HCIC; MEP HyperCel™), and then further purified using a CM 650M ion exchange chromatography …
The Role Of Conflict Management On Virtual Team Performance And Satisfaction, Pilar Pazos, Anil Ustun, Rolando Delaguila
The Role Of Conflict Management On Virtual Team Performance And Satisfaction, Pilar Pazos, Anil Ustun, Rolando Delaguila
Engineering Management & Systems Engineering Faculty Publications
The role that input factors from project planning processes play on conflict emergence and conflict resolution in virtual teams is not well understood. Of particular interest for this paper is the role that factors during planning stages play in preventing interpersonal conflict, supporting conflict resolution and ultimately enhancing team outcomes in virtual team settings. This study examines the relationships among commitment to team goals, conflict management and team outcomes in virtual teams. First we provide an in depth review of relevant empirical findings. Next, we describe a study examining the relationships between three sets of variables: 1) goal commitment, 2) …
Process Modeling System For Press Cure, Closed-Cavity Tooled Thick Composites, Arven H. Saunders
Process Modeling System For Press Cure, Closed-Cavity Tooled Thick Composites, Arven H. Saunders
Industrial, Manufacturing, and Systems Engineering Dissertations - Archive
Thick structural composite parts often use press curing with closed-cavity tooling for achieving dimensional tolerances. A commonly encountered defect for these parts is fiber waviness, whick limits its structural strength. The yield for such parts often suffers due to trial and error methods used to develop successful cure processes. In addition, yield for these parts suffers due to material variation. The objectives of this research were to: develop and validate a simplified yet practical cure process model for press cured thick composite parts, utilize the model in order to seek time-efficient optimized cure processes, investigate the effects of material variation …
Improving Throughput And Predictability Of High-Volume Business Processes Through Embedded Modeling, Joseph S. Dekeyrel
Improving Throughput And Predictability Of High-Volume Business Processes Through Embedded Modeling, Joseph S. Dekeyrel
Electronic Theses and Dissertations
Being faster is good. Being predictable is better. A faithful model of a system, loaded to reflect the system's current state, can then be used to look into the future and predict performance. Building faithful models of processes with high degrees of uncertainty can be very challenging, especially where this uncertainty exists in terms of processing times, queuing behavior and re-work rates. Within the context of an electronic, multi-tiered workflow management system (WFMS) the author builds such a model to endogenously quote due dates. A WFMS that manages business objects can be recast as a flexible flow shop in which …
Models For Evaluation Of Supply Chain Risk With Application To Healthcare Management, Ford Guangfu Zeng
Models For Evaluation Of Supply Chain Risk With Application To Healthcare Management, Ford Guangfu Zeng
Industrial, Manufacturing, and Systems Engineering Dissertations - Archive
Over the past two decades, supply chain management has come to be a key component of organization competitiveness and effectiveness. In the same period, most organizations have put a great deal of effort into improving their own and their supplier's supply chain performance. To a large extent, much of this effort has been aimed at improving the efficiency of supply chain operations. However, organizations have ignored or played down the risks from supply chain disruptions when developing supply strategies, which focus on cost reduction. It is proposed, therefore, that one such standard measure should measure the risk involved with organizations …
Mathematical Optimization Techniques For Managing Selective Catalytic Reduction For Coal-Fired Power Plants, Passakorn Phananiramai
Mathematical Optimization Techniques For Managing Selective Catalytic Reduction For Coal-Fired Power Plants, Passakorn Phananiramai
Industrial, Manufacturing, and Systems Engineering Dissertations - Archive
Coal is one of the most important energy sources in the U.S. However, it is also one of the biggest air polluters where the major emissions generated from coal combustion are oxides of nitrogen (NOx). NOx leads to ozone formation and make people more susceptible to respiratory illness. The US Environmental Protection Agency (EPA) has steadily tightened the regulation for NOx emissions that can be discharged into the atmosphere. Many techniques and technologies can all assist with NOx removal. However, to meet upcoming EPA mandates, more aggressive technique such as Selective Catalytic Reduction (SCR) is highly recommended. SCR is an …
Design Of The Layout Of A Manufacturing Facility With A Closed Loop Conveyor With Shortcuts Using Queueing Theory And Genetic Algorithms, Vernet Michael Lasrado
Design Of The Layout Of A Manufacturing Facility With A Closed Loop Conveyor With Shortcuts Using Queueing Theory And Genetic Algorithms, Vernet Michael Lasrado
Electronic Theses and Dissertations
With the ongoing technology battles and price wars in today's competitive economy, every company is looking for an advantage over its peers. A particular choice of facility layout can have a significant impact on the ability of a company to maintain lower operational expenses under uncertain economic conditions. It is known that systems with less congestion have lower operational costs. Traditionally, manufacturing facility layout problem methods aim at minimizing the total distance traveled, the material handling cost, or the time in the system (based on distance traveled at a specific speed). The proposed methodology solves the looped layout design problem …
A Model To Integrate Sustainability Into The User-Centered Design Process, Adrienne Shevonne Brown
A Model To Integrate Sustainability Into The User-Centered Design Process, Adrienne Shevonne Brown
Electronic Theses and Dissertations
With concerns for the environment becoming more prevalent in business and the government, it is increasingly important to re-evaluate and update processes to include sustainability considerations early in the design process. In response to this charge, this research effort was designed to integrate sustainability factors into the usercentered design process. The results of this research highlight the benefits of sustainability requirement planning, as well as those derived from integrating sustainability into the current user-centered design model
A Framework For Quantifying Sustainability Of Lean Implementation In Healthcare Organizations, Haitham Ahmed Bahaitham
A Framework For Quantifying Sustainability Of Lean Implementation In Healthcare Organizations, Haitham Ahmed Bahaitham
Electronic Theses and Dissertations
Due to the remarkable positive effect of lean adoption in various firms in the manufacturing sector, it has been adopted by several organizations within the healthcare industry. Although the rate of adopting lean by hospitals in the developed countries is slower than it should be, it proved to be effective in helping healthcare organizations maintain or even improve their quality of care while containing their related costs. However, such adoption did not take place until the beginning of the new millennium. And with such adoption, it has been accompanied with major challenges related to proper lean implementation, sustainability of achieved …
Dynamic Routing On Stochastic Time-Dependent Networks Using Real-Time Information, Ali R. Guner
Dynamic Routing On Stochastic Time-Dependent Networks Using Real-Time Information, Ali R. Guner
Wayne State University Dissertations
In just-in-time (JIT) manufacturing environments, on-time delivery is one of the key performance measures for dispatching and routing of freight vehicles. Both the travel time delay and its variability impact the efficiency of JIT logistics operations, that are becoming more and more common in many industries, and in particular, the automotive industry. In this dissertation, we first propose a framework for dynamic routing of a single vehicle on a stochastic time dependent transportation network using real-time information from Intelligent Transportation Systems (ITS). Then, we consider milk-run deliveries with several pickup and delivery destinations subject to time windows under same network …
Modeling And Surveillance Of Pandemic Influenza Outbreaks, Diana Prieto
Modeling And Surveillance Of Pandemic Influenza Outbreaks, Diana Prieto
USF Tampa Graduate Theses and Dissertations
Pandemic outbreaks are unpredictable as to their virus strain, transmissibility, and impact on our quality of life. Hence, the decision support models for mitigation of pandemic outbreaks must be user-friendly and operational, and also incorporate valid estimates of disease transmissibility and severity. This dissertation research is aimed at 1) reviewing the existing pandemic simulation models to identify their implementation gaps with regard to usability and operability, and suggesting research remedies, 2) increasing operability of simulation models by calibrating them via an epidemiological model that estimates infection probabilities using viral shedding profiles of concurrent pandemic and seasonal influenza, and 3) developing …
Cap-And-Trade Modeling And Analysis For Electric Power Generation Systems, Patricio Rocha
Cap-And-Trade Modeling And Analysis For Electric Power Generation Systems, Patricio Rocha
USF Tampa Graduate Theses and Dissertations
Cap-and-trade is the most discussed CO2 emissions control scheme in the U.S. It is a market-based mechanism that has been used previously to successfully reduce the levels of SO2 and NOx emitted by power generators. Since electricity generators are responsible for about 40% of the CO2 emissions in the U.S., the implementation of CO2 cap-and-trade will have a significant impact on electric power generation systems. In particular, cap-and-trade will influence the investment decisions made by power generators. These decisions in turn, will affect electricity prices and demand. If the allowances (or emission permits) created by …
Development Of Risk Uncertainty Factors From Historical Nasa Projects, Tahani R. Amer
Development Of Risk Uncertainty Factors From Historical Nasa Projects, Tahani R. Amer
EMSE Doctoral Projects
NASA is a good investment of federal funds and strives to provide the best value to the nation. NASA has consistently budgeted to unrealistic cost estimates, which are evident in the cost growth in many of its programs. In this investigation, NASA has been using available uncertainty factors from the Aerospace Corporation, Air Force, and Booz Allen Hamilton to develop projects' risk posture. NASA has no insight into the developmental of these factors and, as demonstrated here, this can lead to unrealistic risks in many NASA Programs and projects (P/p). The primary contribution of this project is the development of …
Mixed Integer Programming Models For Selecting Ground-Level Ozone Control Strategies, Wei-Che Hsu
Mixed Integer Programming Models For Selecting Ground-Level Ozone Control Strategies, Wei-Che Hsu
Industrial, Manufacturing, and Systems Engineering Dissertations - Archive
Under the Clean Air Act (CAA) in 1990, the U.S Environmental Protection Agency (EPA) was required to set National Ambient Air Quality Standards (NAAQS) for six common air pollutants that are considered harmful to public health and the environment. Ground–level ozone was one of the six criteria pollutants monitored by the EPA and considered the most widespread health threat. Two precursors of ground level ozone are nitrogen oxides (NOx) and volatile organic compounds (VOC) and the common sources of these two precursors include on–road vehicles, non–road engines, area sources, point sources, and biogenic and miscellaneous sources. An area …
Acuta Enews January 2011 Vol. 40, No. 1
Acuta Enews January 2011 Vol. 40, No. 1
ACUTA Newsletters
In this issue.....
Board approves slate of nominees
From ACUTA headquaters: rebalancing IT for the future.......... Jeri A. Semer, CAE, Executive Dir.
Nominate now for ACUTA Ruth A. Michalecki Leadership Award
Tech Talk: doing more with less, but in a good way........ Kevin Tanzillo, Dux PR
Washington Update Newsletter
Video Surveillance Technology........ Ron Walczak, RCDD, Walczak Techology Consultants
Forensic Tools: keeping up with the bad guys.......... Gary Audin, Delphi, Inc.
Board Report.............. George Denbow, Univ. of Texas, Austin
Thanks to Event Sponsors for 2010
ACUTA 2011 Event Calender
Info links......... Randy Hayes, Univ. of Northern Iowa
Welcome New Members
Check …
Multivariate Adaptive Regression Spline Based Framework For Statistically Parsimonious Adaptive Dynamic Programming, Subrat Sahu
Multivariate Adaptive Regression Spline Based Framework For Statistically Parsimonious Adaptive Dynamic Programming, Subrat Sahu
Industrial, Manufacturing, and Systems Engineering Dissertations - Archive
Central to Dynamic Programming (DP) is the `cost-to-go' or `future value' function, which is obtained via actually solving the Bellman's equation and central to Approximate Dynamic Programming (ADP) is the use of an approximation of the future value function. The exact DP algorithm seeks to compute and store a table consisting of one cost-to-go value for each point in the state space and its usefulness is limited by the curse of dimensionality, which renders the methodology computationally intractable in the face of real life problems with high dimensional state space and in the face of continuous state variables. ADP methodology …
Arguing Security Of Generic Avionic Mission Control Computer System (Mcc) Using Assurance Cases, Bhanuchander Reddy Poreddy, Steven Corns
Arguing Security Of Generic Avionic Mission Control Computer System (Mcc) Using Assurance Cases, Bhanuchander Reddy Poreddy, Steven Corns
Engineering Management and Systems Engineering Faculty Research & Creative Works
An assurance case is a body of evidence organized into an argument demonstrating that some claim about a system holds, i.e., is assured. Assurance cases are used to comment about system safety, and it serves as a mean to show that the systems acceptably satisfy their safety properties. Assurance cases perform rigorous security analysis on safety-critical complex systems. in this paper, the analysis done is an approach to documenting an assurance case for system security, i.e., a security assurance case. the paper deals with the Assurance cases for Generic Avionic Mission Control Computer system, by constructing tangible claims and investigating …
Local Linear Regression For Soft-Sensor Design With Application To An Industrial Deethanizer, Zhanxing Zhu, Francesco Corona, Amaury Lendasse, Roberto Baratti, Jose A. Romagnoli
Local Linear Regression For Soft-Sensor Design With Application To An Industrial Deethanizer, Zhanxing Zhu, Francesco Corona, Amaury Lendasse, Roberto Baratti, Jose A. Romagnoli
Engineering Management and Systems Engineering Faculty Research & Creative Works
Soft-Sensors for Estimating in Real-Time Important Quality Variables Are a Key Technology in Modern Process Industry. the Successful Development of a Soft-Sensor Whose Performance Does Not Deteriorate with Time and Changing Process Characteristics is Troublesome and Only Seldom Achieved in Real-World Setups. the Design of Soft-Sensors based on Local Regression Models is Becoming Popular. Simplicity of Calibration, Ability to Handle Nonlinearities And, Most Importantly, Reduced Maintenance Costs While Retaining the Requested Accuracy Are the Major Assets. in This Paper, We Introduce Several Approaches for Defining an Appropriate Locality Neighborhood and We Propose a Recursive Version of Local Linear Regression for …
Toward A Technology Management Core: Defining What The Technology Manager Needs To Know, Mark Doggett, Pam Mcgee, Sophia Scott
Toward A Technology Management Core: Defining What The Technology Manager Needs To Know, Mark Doggett, Pam Mcgee, Sophia Scott
SEAS Faculty Publications
With the increasing demands on organizations to do “more with less,” and produce acceptable market results, productivity and performance standards continually raise the expectations on competitive success. To meet these expectations, organizations should create learning opportunities that combine the application of technical management skills along with the softer skills involved in people management. Technical managers with little training or past experience with nontechnical skills often perform poorly in technical management positions (Kroecker, 2007). Because this generation lives in a highly technical environment, managers need to be proficient in dealing with knowledge workers and systems; therefore, there is a growing emphasis …
Critical Success Factors In The Re-Engineering Of 21st Century Supply Chains, Edward Sweeney
Critical Success Factors In The Re-Engineering Of 21st Century Supply Chains, Edward Sweeney
Practitioner Journals
No abstract provided.
An Integrated Decision Support Framework For Remanufacturing In The Automotive Industry, Akhilesh Kumar
An Integrated Decision Support Framework For Remanufacturing In The Automotive Industry, Akhilesh Kumar
Wayne State University Dissertations
In today's global economy, firms are seeking any and every opportunity to differentiate from competitors by reducing supply chain costs and adding value to end customers. One increasingly popular option, under growing consumer awareness and increasing legislation, is to reintegrate returned products into the supply chain to achieve economic benefits as well as improve sustainability. An important class of such "reverse" goods flows has to do with remanufacturing (reman), which refers to activities that restore returned products ("cores") or their major modules to operational condition for using in place of new product or distributing through other channels (e.g., spare parts). …
Ambient- And High-Temperature Mechanical Properties Of Isochronally Aged Al–0.06sc, Al–0.06zr And Al–0.06sc–0.06zr (At.%) Alloys, Keith E. Knipling, David N. Seidman, David C. Dunand
Ambient- And High-Temperature Mechanical Properties Of Isochronally Aged Al–0.06sc, Al–0.06zr And Al–0.06sc–0.06zr (At.%) Alloys, Keith E. Knipling, David N. Seidman, David C. Dunand
United States Navy: Publications
Ambient- and high-temperature precipitation strengthening are investigated in Al–0.06Sc, Al–0.06Zr and Al–0.06Sc–0.06Zr (at.%) alloys. Following solidification, Sc is concentrated at the dendrite peripheries while Zr is segregated at the dendrite cores. During isochronal aging, precipitation of Al3Sc (L12) commences between 250 and 300 °C for Al–0.06Sc, and reaches a 429 MPa peak microhardness at 325 °C. For Al–0.06Zr, precipitation of Al3Zr (L12) first occurs between 400 and 425 °C and reaches a 295 MPa peak microhardness at 475 °C. A pronounced synergistic effect is observed when both Sc and Zr are present. Above 325 °C, Zr …
A Phase Field Model Of Deformation Twinning: Nonlinear Theory And Numerical Simulations, J. D. Clayton, J. Knap
A Phase Field Model Of Deformation Twinning: Nonlinear Theory And Numerical Simulations, J. D. Clayton, J. Knap
United States Army: Publications
A continuum phase field theory and corresponding numerical solution methods are developed to describe deformation twinning in crystalline solids. An order parameter is associated with the magnitude of twinning shear, i.e., the lattice transformation associated with twinning. The general theory addresses the following physics: large deformations, nonlinear anisotropic elastic behavior, and anisotropic phase boundary energy. The theory is applied towards prediction of equilibrium phenomena in the athermal and non-dissipative limit, whereby equilibrium configurations of an externally stressed crystal are obtained via incremental minimization of a free energy functional. Outcomes of such calculations are elastic fields (e.g., displacement, strain, stress, and …
Investigations Of Transcript Expression In Fathead Minnow (Pimephales Promelas) Brain Tissue Reveal Toxicological Impacts Of Rdx Exposure, Kurt A. Gust, Mitchell S. Wilbanks, Xin Guan, Mehdi Pirooznia, Tanwir Habib, Leslie Yoo, Henri Wintz, Chris D. Vulpe, Edward J. Perkins
Investigations Of Transcript Expression In Fathead Minnow (Pimephales Promelas) Brain Tissue Reveal Toxicological Impacts Of Rdx Exposure, Kurt A. Gust, Mitchell S. Wilbanks, Xin Guan, Mehdi Pirooznia, Tanwir Habib, Leslie Yoo, Henri Wintz, Chris D. Vulpe, Edward J. Perkins
United States Army: Publications
Production, usage and disposal of the munitions constituent (MC) cyclotrimethylenetrinitramine (RDX) has led to environmental releases on military facilities. The chemical attributes of RDX are conducive for leaching to surface water which may put aquatic organisms at risk of exposure. Because RDX has been observed to cause aberrant neuromuscular effects across a wide range of animal phyla, we assessed the effects of RDX on central nervous system (CNS) functions in the representative aquatic ecotoxicological model species, fathead minnow (Pimephales promelas). We developed a fathead minnow brain-tissue cDNA library enriched for transcripts differentially expressed in response to RDX and …
Fatigue-Induced Grain Coarsening In Nanocrystalline Platinum Films, Roi A. Meirom, Daan Hein Alsem, Amber L. Romasco, Trevor Clark, Ronald G. Polcawich, Jeffrey S. Pulskamp, Madan Dubey, Robert O. Ritchie, Christopher L. Muhlstein
Fatigue-Induced Grain Coarsening In Nanocrystalline Platinum Films, Roi A. Meirom, Daan Hein Alsem, Amber L. Romasco, Trevor Clark, Ronald G. Polcawich, Jeffrey S. Pulskamp, Madan Dubey, Robert O. Ritchie, Christopher L. Muhlstein
United States Army: Publications
Mechanisms to explain the unique mechanical behavior of nanograined metals focus primarily on grain and grain boundary mobility. In most nanograined metal materials systems (both pure and alloyed) it has not been possible to decouple these time- and cycle-dependent contributions. In contrast, the 460 nm thick, (1 1 1) textured, nanograined platinum thin films evaluated in this work have robust grain morphologies that allow us to uniquely identify the fatigue damage accumulation processes. Unlike other reports of face-centered cubic metal behavior, the platinum films exhibited a particularly limited range of fatigue crack growth (<3 MPa √m) with extremely large (~10.5) power law exponents typically associated with fatigue of structural ceramics and ordered intermetallics. Transmission electron microscopy and fatigue crack growth data suggest that the crack growth mechanism appears to be intrinsic in origin and dislocation mediated.
Thermoreversible And Remendable Glass–Polymer Interface For Fiber-Reinforced Composites, Amy M. Peterson, Robert E. Jensen, Giuseppe R. Palmese
Thermoreversible And Remendable Glass–Polymer Interface For Fiber-Reinforced Composites, Amy M. Peterson, Robert E. Jensen, Giuseppe R. Palmese
United States Army: Publications
Adhesion of the reinforcement to the polymer matrix is essential for load transfer from the polymer matrix to the reinforcement material in fiber-reinforced composites. The reversible Diels–Alder reaction between a furan-functionalized epoxy-amine thermosetting matrix with a maleimide-functionalized glass fiber was used to impart remendability at the polymer–glass interface for potential application in glass fiber-reinforced composites. At room temperature the Diels–Alder adduct is formed spontaneously and above 90 °C the adduct breaks apart to reform the original furan and maleimide moieties. Healing of the interface was investigated with single fiber microdroplet pull-out testing. Following complete failure of this interface, significant healing …
Micro-Cracks Informed Damage Models For Brittle Solids, Xiaodan Ren, Jiun-Shyan Chen, Jie Li, T. R. Slawson, M. J. Roth
Micro-Cracks Informed Damage Models For Brittle Solids, Xiaodan Ren, Jiun-Shyan Chen, Jie Li, T. R. Slawson, M. J. Roth
United States Army: Publications
A class of micro-cracks informed damage models for describing the softening behavior of brittle solids is proposed, in which damage evolution is treated as a consequence of micro-crack propagation. The homogenized stress–strain relation in the cracked microscopic cell defines the degradation tensor, which can be obtained by the equivalence between the averaged strain energy of the microscopic cell and the strain energy density of the homogenized material. This energy equivalence relationship serves as an energy bridging vehicle between the damaged continuum and the cracked microstructure. Several damage evolution equations are obtained by this energy bridging method. The size effect of …
Antimicrobial Decapeptide Ksl-W Attenuates Candida Albicans Virulence By Modulating Its Effects On Toll-Like Receptor, Human Β-Defensin, And Cytokine Expression By Engineered Human Oral Mucosa, A. Semlali, K. P. Leung, S. Curt, M. Rouabhia
Antimicrobial Decapeptide Ksl-W Attenuates Candida Albicans Virulence By Modulating Its Effects On Toll-Like Receptor, Human Β-Defensin, And Cytokine Expression By Engineered Human Oral Mucosa, A. Semlali, K. P. Leung, S. Curt, M. Rouabhia
United States Army: Publications
We investigated the toxicity of synthetic antimicrobial decapeptide KSL-W on normal human gingival epithelial cell cultures, its effect on Candida albicans adhesion and growth, and the activation of epithelial cell innate immunity. Our results indicate that KSL-W had no toxic effect on cell adhesion or growth, suggesting its safe use with human cells. Pre-treating C. albicans with KSL-W attenuated the yeast’s virulence as demonstrated by its reduced adhesion and growth on engineered human oral mucosa epithelium and the subsequent decreased expression of some innate defense molecules by targeted epithelial cells. Indeed, the expression of Toll-like receptors and human β-defensins was …