Digital Commons Network^™

3d Reconstruction Of Spatial Transcriptomics With Spatial Pattern Enhanced Graph Convolutional Neural Network, Chen Tang, Yuansheng Zhou, Xue Xiao, Lei Dong, Lei Yu, Qiwei Li, Guanghua Xiao, Lin Xu

Faculty, Staff and Student Publications

Spatially resolved transcriptomics (SRT) is a promising new technology that enables simultaneous analysis of gene expression and spatial information for biomedical research. However, the existing statistical and deep learning algorithms used for analyzing SRT data rely solely on two-dimensional (2D) spatial coordinates, which limits their ability to accurately identify spatial domains, spatially variable genes (SVGs), cell-to-cell communications, and developmental trajectories in a three-dimensional (3D) spatial manner. To address these limitations, we introduced Spa3D, which utilized the anti-leakage Fourier transform and graph convolutional neural network model to reconstruct 3D-based spatial structures from multiple 2D SRT slices. We demonstrate that Spa3D is …

Wikipedia And Archival Internships: Preparing Memory Workers For Inclusive Practice, April K. Anderson-Zorn

Faculty and Staff Publications – Milner Library

Archival internships guided by the Rayfield Archives offer opportunities for future archivists, public historians, and other memory workers to gain hands-on experience working with historical records and their communities. Along with archival processing, exhibit curation, and metadata, interns can also learn to create authoritative Wikipedia entries for underrepresented members of the ISU community. From its early, grant-funded stages in 2020 to its current iteration as an interactive, guided project, the Wikipedia internship at the Rayfield Archives prepares students for inclusive practice in memory work in the classroom and the field.

Teaching Students How To Access The World: Information Fluency Modules In World Criminal Justice Systems Courses, Grace Allbaugh, Chad M. Kahl, Dawn Beichner

Faculty and Staff Publications – Milner Library

This presentation discusses a long-term collaboration between Milner Library and the Department of Criminal Justices Sciences to bring information fluency training to students in CJS 369: World Criminal Justice Systems. Learn how it has changed from pen and paper, responded to COVID, and where it's at now.

Experimental And Simulation Analysis For Different Pot-In-Pot Indirect Heating Scenarios For Cooking Applications, Pamella K. Kajumba, Jimmy Chaciga, Denis Okello, Karidewa Nyeinga

Tanzania Journal of Science

The paper presents simulation and experimental results to demonstrate heat transfer performance during cooking that can be practical in pot-in-pot arrangements for indirect cooking/heating. The cases included single pots, pot-in-pot with oil, and pot-in-pot with no oil. The aim was to optimize the heat transfer through conduction and the cooking process for a recently developed small-scale sensible heat storage system integrated with a cooking unit. Cooking experiments reported were carried out using an electric hot plate with a power rating of 1.8 kW, 220V. Temperature measurements were recorded using a TC-08 data logger. The heating rates were analyzed for the …

Appropriate Wireless Technology For Blue Data Communication To Enhance Artisanal Fishery, Abdi T. Abdalla, Eva Shayo, Angelina Misso, Baraka Maiseli, Kwame S. Ibwe, Narriman Jiddawi, Moses Ismail

Tanzania Journal of Science

The paper examines the development of a system architecture to support smart fishing. This includes the establishment of a blue data center, which would allow government agencies and research institutions to access fisheries data. The goal is to provide policymakers with the tools they need to efficiently manage artisanal fisheries resources. The architecture also incorporates wireless communication components that are suitable for small-scale fishers in remote areas. The study delves into the selection of appropriate wireless communication technology for transmitting fishing data to the communication center. Factors such as coverage range, data rates, and cost implications are taken into consideration. …

Qualitative And Numerical Observations Into The Career Trajectories Of Early Career Academics: A Mathematical Model Approach, Oluwatayo M. Ogunmiloro

Tanzania Journal of Science

This study develops and analyzes a mathematical model that describes the interplay among different researcher groups within academia by focusing on how variables such as mentorship, access to funding, and academic peer influence affect the career trajectories of early-career, experienced, redundant, and successful researchers. Using stability theory and relevant theorems of differential equations, this study ensures the existence, uniqueness, positivity, and boundedness of the model's solutions. Additionally, the model’s equilibrium states, are analyzed to determine the local asymptotic stability. Numerical simulations using the Runge-Kutta fourth-order (RK4) method, implemented in Python, are performed to illustrate issues related to career growth within …

Research And Innovation Update, January 7, 2026, Office Of The Vice President For Research And Innovation

Office of Research, Economic Engagement and Outreach

No abstract provided.

Re: Comment Letter For Draft Clark Tailings Consolidated Waste Management Area (Ctcwma) 2024 Data Summary Report (Dated October 15, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Minority Leaders’ Impact On Corporate Diversity And Organizational Change, Nana Kwasi Amponsah

Walden Dissertations and Doctoral Studies

Workplace diversity continues to face criticism due to the limited representation of minority groups, with little progress made in the corporate sector. Despite corporations’ efforts to increase diversity and inclusion in the workplace, a notable lack of minority leadership persists in upper management roles. The purpose of this explanatory sequential mixed-method study was to explore the factors that affect the selection of minority leaders and how corporate executives utilize diversity, equity, and inclusion (DEI) initiatives to foster significant organizational change, even in the face of ongoing underrepresentation in upper management. Social dominance theory, anti-egalitarianism, and social construction theory grounded this …

Serum Protein Signatures For Breast Cancer Detection In Treatment-Naïve African American Women Using Integrated Proteomics And Pattern Analysis, Padma Uppala, Elmer Rivera, Hyun Kwon, Sharon S. Lum

Faculty Publications

No abstract provided.

Priestly Christology And Holiness: Christ’S Priesthood And The Sanctification Of Believers, Adriani Rodrigues

Faculty Publications

No abstract provided.

Centralized Qr Trust Repository (Cqtr) With Merchant Name Uniqueness For Fraud Prevention In Qr Code Payments, Alok Roy Mr

Defensive Publications Series

The disclosed systems and methods use a Centralized QR Trust Repository (CQTR) for securing and streamlining merchant onboarding and transaction validation, and to address critical challenges in QR-based payments such as cross-acquirer fraud and counterfeit QR codes system performs transaction validation. At the time of onboarding, merchant details such as merchant or business name, account information, and KYC are collected by client servers and CQTR conducts uniqueness validation to ensure name uniqueness across all acquirers. CQTR performs similarity checks, including fuzzy matching and phonetic analysis and prevents duplicate registrations. After successful validation, CQTR generates and registers unique QR codes static …

Ai-Driven Application Intent For Seamless End-To-End Guaranteed Quality Of Service Packet Forwarding, Jaganbabu Rajamanickam, Madhan Sankaranarayanan, Paul Jensen, Sumant Mali, Krishna Deevi

Defensive Publications Series

A next-generation approach to network Quality of Service (QoS) is proposed herein that enables direct, in-band communication of application intent using an innovative extension header, such as an Internet Protocol version 6 (IPv6) extension header. Using the proposed innovation, applications can embed concise, high-level QoS requirement strings or "intents" (e.g., 'ultra-low latency', 'AI/ML Training', etc.) into packet headers, allowing ingress edge devices to interpret these intents using a local policy database. Advanced matching engines, potentially leveraging machine learning, can enable flexible and semantically rich interpretation of these requirements/intents, surpassing traditional rigid classifications.

Read My Lips: No New Constructs! Construct Proliferation As A Threat To The Future Of I-O Psychology, Nathan A. Bowling, Valerie I. Sessa, Jonathan A. Shaffer, George C. Banks

Department of Psychology Faculty Scholarship and Creative Works

Industrial and organizational (I-O) psychology recognizes dozens of different constructs, including several individual differences, environmental variables, job attitudes, and work-related behaviors. It is, of course, necessary to retain a variety of constructs in order to adequately capture the complexities, subtleties, and diversity of work-related phenomena. But do the many constructs recognized by I-O psychologists all serve a useful purpose? Or has our field been too eager to welcome redundant, unnecessary constructs into the fold? And if I-O psychology has embraced too many unnecessary constructs, then what—if anything—should we do about it? In the current focal article, we first discuss when …

Health Impacts Of Migration And Policy On The Iranian Diaspora, Jihye Lee, Mitra Naseh, Sahar Badiezadeh, Sarvenaz Taridashti, Erick Da Luz Scherf

Department of Psychology Faculty Scholarship and Creative Works

Migration is shaped by a complex interplay of political, economic, and social factors that drive individuals to seek stability and better prospects abroad. Since the 1979 Islamic Revolution, Iran has experienced significant emigration of its highly educated population, driven by political instability, economic challenges, and restrictive societal norms. This study explores how U.S. immigration policies affect the health and well-being of highly educated Iranian immigrants, with particular attention given to the impact of nationality-based restrictions on psychosocial outcomes. Using a phenomenological approach, we analyzed in-depth interviews with 40 participants to examine the lived experiences of highly educated Iranian immigrants in …

The Effect Of Exercise On Cognitive Function In The Elderly, Anna Petersen

Advocate GME

No abstract provided.

Powering Up Clinical Scholarship In Evidence-Based Practice For Nurse Residents, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This Nurse Residency Evidence-Based Practice workshop introduces core concepts of clinical scholarship for nurse residents, emphasizing how to turn clinical questions into structured literature searches and use HSLIC resources to support scholarly projects. Topics include framing answerable clinical questions (e.g., PICOT), navigating key clinical information tools (PubMed, CINAHL, PsycINFO, EMBASE, ClinicalKey, UpToDate), applying practical literature search techniques (Boolean operators, truncation, wildcards, proximity operators, subject headings), documenting basic search strategies, accessing full text (LibKey Nomad, proxy authentication, interlibrary loan and document delivery), and a brief introduction to critical appraisal tools and publishing supports available through HSLIC.

Pathways, Outputs And Impact Of Nih-Supported Bioinformatics And Genomics Graduate Trainees In Africa, Daudi Jjingo, Andrew Walakira, Suhaila Hashim, Cisse Cheickna, Ronald Galiwango, Caleb Kibet, Florence N Kivunike, Gerald Mboowa, Fredrick Elishama Kakembo, Babajide Ayodele, Jean-Baka Domelevo Entfellner, Santie De Villiers, Karen Wambui, Segun Fatumo, Tinashe Chikowore, John Mukisa, Alfred Ssekagiri, Nicholas Bbosa, Julius Mulindwa, Samuel Kyobe, Mike Nsubuga, Grace Kebirungi, Eric Katagirya, Savannah Mwesigwa, Ibra Lujumba, Rogers Kamulegeya, Samuel Kirimunda, Stephen Kanyerezi, Shahiid Kiyaga, Ivan Sserwadda, Davis Kiberu, Bernard S Bagaya, Julius Okwir, Patricia Nabisubi, Grace Nabakooza, Mugume Twinamatsiko Atwine, Ricard Sserunjogi, Rolanda Julius, Mariam Quiñones, Meghan Mccarthy, Phillip Cruz, Karlynn Noble, Christopher J Whalen, Darrell Hurt, Maria Y Giovanni, Michael Tartakovsky, Deogratius Ssemwanga, John M Kitayimbwa, Steven J Reynolds, Christopher C Whalen, Andrew Kambugu, Neil A Hanchard, Li Jian, Peter Amoako-Yirenkyi, Graeme Mardon, I King Jordan, Samson Pandam Salifu, Mamadou Wele, Ezekiel Adebiyi, Jeffrey G Shaffer, Seydou Doumbia, David Patrick Kateete, Michelle Skelton, Nicola Mulder, Jonathan K Kayondo, Daniel Masiga, H3africa Consortium

Faculty, Staff and Students Publications

Global biomedical and health research is increasingly relying on genomic and computational approaches, largely driven by the increasing volumes of nucleic acid sequencing. Concurrently, epidemiological studies and clinical records are generating enormous amounts of data amenable to disease modeling, machine learning, and artificial intelligence techniques. Bioinformatics and data science expertise is therefore essential for improved population health. Accordingly, in 2012, the US National Institutes of Health (NIH) in partnership with the Wellcome Trust, and with support from the African Society for Human Genetics, initiated the H3Africa (Human Heredity and Health in Africa) consortium. One of its key goals was to …

Employment Stability And Security Of Low-Wage Workers In The United States, Mathieu Despard, Guangli Zhang, Stephen Roll

Center for Social Development Research

One quarter of workers in the United States make $35,000 or less, and nearly half of these are between 35 and 64 years old. Forty percent are caring for children in the home. As temporary and gig working arrangements become increasingly common, this brief explores the stability of work and income for low-wage workers. The analyses draw upon data from the Workforce Economic Inclusion and Mobility survey administered to a nationally representative sample of U.S. workers earning less than 250% of the federal poverty line. The findings from this work have direct implications for employment practices and labor policies.

Characterization Of Inflammatory Pseudotumors In A Large Animal Model Of Liver Cancer, Erik N K Cressman, Samantha Hicks, Natalie W Fowlkes, Danielle L Stolley, Maria Sophia Stenkamp

Faculty, Staff and Student Publications

Background: The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease. Transgenic approaches hold promise in addressing this complex problem. One such model, the Oncopig, has been reported to develop tumors of up to 4 cm in diameter within 7-14 days at sites of in situ vector inoculation. However, the resulting lesions reportedly contained an extensive inflammatory component that has not been evaluated in detail.

Methods: Herein, we describe our results from multiparametric characterization of the lesions generated using liver biopsy cores incubated in vector solution and replaced …

Defective Dna Damage Response Is A Targetable Therapeutic Vulnerability In Esr1 Mutant Breast Cancer, Sarah K Herzog, Jessica H Stevens, Guowei Gu, Sandra L Grimm, Kloma Cardoza, Autumn G M Hawkins, Hangqing Lin, Daniela Ramos, Amanda R Beyer, David G Edwards, Derek Dustin, Harry J Yang, Nicole Liang, Ashfia F Khan, Tasneem Bawa-Khalfe, Daniel J Mcgrail, Shiaw-Yih Lin, Cristian Coarfa, Suzanne A W Fuqua

Faculty, Staff and Student Publications

ESR1 mutations are the leading cause of endocrine therapy resistance and progression in ER-positive metastatic breast cancer. ESR1 mutations are detected in ~50% of metastatic breast cancer patients, and identification of effective targeted therapeutics are critically needed. Here, we identified enrichment of dysregulated replication stress and DNA damage responses in multiple ESR1 mutant models. Targeting the replication stress response utilizing checkpoint inhibition in combination with PARP inhibition synergistically suppressed growth, induced cell cycle arrest, and attenuated DNA replication. PARP inhibition blocked metastatic dissemination in vivo and reduced both PARP1 and ER-regulated protein expression. PARP trapping by olaparib treatment with or …

Machine Learning-Based Multimodal Biomarkers Enable Accurate Diagnosis And Early Detection Of Pancreatic Ductal Adenocarcinoma, Tsung-Hung Yao, Warapen Treekitkarnmongkol, Nagireddy Putluri, Deivendran Sankaran, Tristian Nguyen, Seetharaman Balasenthil, Mark W Hurd, Meng Chen, Randall E Brand, Paul D Lampe, Abu Hena M Kamal, Vasanta Putluri, Tony Y Hu, Anirban Maitra, Eugene J Koay, Ann M Killary, Subrata Sen, Suprateek Kundu

Faculty, Staff and Students Publications

While there has been some progress on discovering clinically validated biomarkers for early detection in pancreatic ductal adenocarcinoma (PDAC), several challenges remain. Most approaches rely on single-modality biomarkers with limited sensitivity and/or specificity. Using data from a multicenter study with an age-matched cohort (n = 203 with healthy controls n = 46, pancreatitis controls n = 36, and diagnosed cases n = 121), we developed a machine learning approach integrating 2,096 microRNAs, 125 metabolites, and CA19-9. Our method performs unsupervised selection of an optimal subset of biomarkers with maximal discriminatory power for diagnosis and early detection. In training data, the …

Investigating The Role Of Team Chemistry In Winning Percentage Of Collegiate Women’S Soccer Teams At The End Of A Fall Competitive Season, Erin Kasmarik-Mallett

Doctorate in Kinesiology

This study examined the relationship between team chemistry and winning percentage in collegiate women’s soccer teams following a fall competitive season. Using a quantitative, correlational design, team-level survey data assessing cohesion, team mental models, collective efficacy, and leadership were aggregated and analyzed in relation to end-of-season performance. Pearson correlations and linear regression analyses indicated a positive association between overall team chemistry and winning percentage, with team mental models and collective efficacy showing the strongest relationships. These findings support team chemistry as a measurable, multidimensional contributor to performance success and provide empirical guidance for coaches seeking evidence-based strategies to enhance team …

21st-Century Mangrove Expansion Along The Southeastern United States, Lucia I.A. Enes Gramoso, Dustin Carroll, Kyle C. Cavanaugh, Remi Bardou, Michael J. Osland, Tom Van Der Stocken

Faculty Research, Scholarly, and Creative Activity

Warming winter temperatures are driving range expansion of tropical, cold-sensitive mangroves into temperate ecosystems. Along the Atlantic coast of North America, the mangrove range limit is particularly sensitive to climate variability and historical data demonstrate that the mangrove-salt marsh ecotone on this coast has shifted recurrently during recent centuries. However, a comprehensive understanding of how this mangrove-salt marsh ecotone may shift in the future remains lacking. Here, we combine ensemble forecasting of mangrove distribution for the next century with high-resolution oceanographic dispersal simulations, phenological observations, and historical hurricane data to project future mangrove-salt marsh dynamics at the rapidly changing range …

Collaborating With ‘Blue Food’ System Stakeholders To Achieve Optimal Nutritional Health And Wellbeing In Less Affluent Communities, Clare Pettinger, Louise Hunt, Carol Wagstaff

School of Health Professions

UK food system transformation is urgently needed, but to date, minimal research has investigated ‘blue foods’ probably because they are ethically nuanced. There exists a paradox whereby materially deprived communities should be eating more fish to meet nutritional requirements, yet there is a global ‘red flag’ around global overfishing. New collaborative and creative solutions are, therefore, needed to tackle such food system inequities. By working together, all voices can be equally heard when decisions are being made to improve the system. Similarly, innovation and disruption of established supply chains will enable better access to healthy, affordable and tasty food that …

Understanding Recruitment To A Randomised Controlled Trial (Rct) During Liver Transplantation: An Observational Mixed-Methods Study Within A Trial (Swat), Katherine Elizabeth Sarah Coppack, Ilya Kantsedikas, Edgar Brodkin, Ee Neng Loh, Gareth Ambler, Suneetha Ramani Moonesinghe, Jeremy Fabes, Vivienne Hannon, Michael Spiro, Duncan Wagstaff

Peninsula Medical School

Objectives Perioperative randomised controlled trials (RCTs) in liver transplantation are relatively infrequent. RCTs performed in this complex patient population need to be robustly conducted to maximise patient benefit and graft utility given the scarcity of donor organs. Recruitment challenges can compromise RCTs and studies in this population face unique challenges due to recipient illness severity, their comorbidities, demographics and the geographical constraints of specialist transplant centres. Emergency presentation and after-hours admission may further limit patients’ capacity or readiness to consider trial participation. This Study Within a Trial (SWAT) specifically explored motivators and barriers to recruitment in patients awaiting liver transplantation.Design …

Back Cover, Michaela Velleno

.RAW Journal of Art and Design

No abstract provided.

Credits, Michaela Velleno

.RAW Journal of Art and Design

No abstract provided.

Artist Index, Maneli Mianji

.RAW Journal of Art and Design

No abstract provided.

'West Coast Orpheus', Maneli Mianji

.RAW Journal of Art and Design

No abstract provided.