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日本から1000人の宣教師を送り出す, Yoshihiko Ariizumi
日本から1000人の宣教師を送り出す, Yoshihiko Ariizumi
Spiritual Proficiency
兄弟姉妹の皆さん、日本から1,000人以上の宣教師を世界へ送り出すという夢を、今日はお話しします。今の100倍を超える努力が必要な、「無謀だ」と思われても仕方のない目標です。けれども、14歳の少年の祈りも、わずか6人で組織された教会も、数字の上では何の見込みもありませんでした。この教会の歴史は「現実的ではない」と言われた歩みの積み重ねであり、主は「小さなことから大いなることが生じる」と約束しておられます。若者やシニアの宣教師は、異国の地で涙の夜も経験しながら、信仰と忍耐を深め、他者を理解する力を養って帰ってきます。そして、家庭、職場、地域に仕え、少子高齢化や孤立に悩む日本の社会を、内側から支える柱となるのです。この夢は一人の力では届きません。だからこそ、どうか一緒に祈ってください。宣教の準備をする若人を励まし、家族として送り出す文化を築きましょう。1,000人は、一人から始まります。その一人が、あなたの家庭から出るかもしれません。
ユーピで10倍の影響力を!, Yoshihiko Ariizumi
ユーピで10倍の影響力を!, Yoshihiko Ariizumi
Spiritual Proficiency
労力の強度や効率性とその時間を10倍にするのは無理です。ストレスが10倍になったら危険です。楽しく、最初は小さなことをコツコツと、そしてユーピの第4原則を使って、サイクルを上手に作り、絶えず目標とやり方を工夫しながら進化させます。そして、何よりも何かを向上させるプロジェクトについては、天父にシニアパートナーになっていただき、細かいことについても相談し、指示を仰ぐのです。天と調和するとき、自分の力をはるかに超えることができるのは当然ですよね。
次に、「影響力」とはどういう風に働かせるのか。自分一人ですべてのことをやろうとしたら限りがあります。でも、誰かほかの人に働きかけて一緒にやれば、自分の影響力を、1.2倍とかにするのは控え目に見積もってもできるでしょう。その輪を広げていくと、3倍とか5倍とかにまでできますよね。さらに、相手の人やグループの人に働きかけて、その人やグループが、関係ある人たちに自分が与えようとしている影響力を、その人たちの方法で周りに発散するように丁寧に訓練していくなら、時間はかかるかもしれませんが、結果的には、自分の力の及ぶ人たちの全体として、自分の10倍以上の影響力を周りの人たちに対して与えることになります。
以上のように考えると、10倍の影響力を社会に対して与えるというのは、あながち不可能ではないと、意外と、根気よくやればできることだと思えてきませんか?
ユーピとは何か?復習編, Yoshihiko Ariizumi
ユーピとは何か?復習編, Yoshihiko Ariizumi
Spiritual Proficiency
ユーピメソッドについて、一般の人にとって親しみやすい表現で簡単に説明されています。もっと深く学びたい人への参考資料もこれを通してアクセスできます。
Building Appreciation For Natural History Collections From Biological Collection Data., Jamie Jensen, Seth Bybee
Building Appreciation For Natural History Collections From Biological Collection Data., Jamie Jensen, Seth Bybee
ScholarsArchive Data
These data represent the pre- and post-survey responses by students in an undergraduate, non-majors biology course given before and after a unit on Natural History Collections. We administered the Revised New Ecological Paradigm (R-NEP; Dunlap et al., 2000) survey which measures pro-environmental attitudes using 15 Likert-scale items.
シオンからの便りシリーズ, Ryuichi Inouye
シオンからの便りシリーズ, Ryuichi Inouye
Spiritual Proficiency
長年教会の教育部門に携わり、とりわけ若い世代との関わりを大切にしてこられた井上兄弟は、豊かな福音知識だけでなく、日々の小さな出来事にも心を配る「実践の人」として知られています。伝道会長、地区代表、神殿会長など、多岐にわたる奉仕を通して培われた独自の視点が、本書のいたるところに息づいています。
収録されているメッセージの数々は、井上兄弟が率いる「シオンのグループ」へ宛てて書き送られた記事を、ほぼ原文のまま年代順にまとめたものです。1つ1つが2~3分で読める分量なので、まずは通読して全体の流れをつかみ、その後トピックごとに立ち止まりながら、日々の生活に少しずつ取り入れていただければと思います。今後は音声やビデオ、エッセイなど多様な形での展開も計画しており、本資料はBYU ScholarsArchiveの「Spiritual Proficiency」セクションに掲載されます。皆さんご自身の霊的な経験も、ぜひお寄せください。
Why Does God Hate Me? A Theistic And Empirical Review Of Attachment To God, Rachel K. Weber
Why Does God Hate Me? A Theistic And Empirical Review Of Attachment To God, Rachel K. Weber
Student Works
General attachment is based on a person’s perceived ability to receive help from their primary caregiver and their perceived worthiness of such help (Bowlby, 1973). This style is separated into four categories that create a paradigm with which future relationships align (Acevedo et al., 2012; Bartholomew & Horowitz, 1991). These four categories are fearful-avoidant, dismissive-avoidant, secure, and anxious-preoccupied (Bartholomew & Horowitz, 1991). This is biologically based and used to ensure an infant’s survival (Bowlby, 1973). These attachment styles are also applicable to one’s relationship to God (Kirkpatrick & Shaver, 1992). Secure attachment to God is indicative of positive religious coping …
Heavy-Duty Diesel Vehicle Deterioration: Impact Of Vehicle Age And Emission Control Technology On Nox Emissions - Preprint, Amber L. Gurecki Allen, Andrew R. Colman, Max D. Sommer, William D. Waddoups, Darrell B. Sonntag
Heavy-Duty Diesel Vehicle Deterioration: Impact Of Vehicle Age And Emission Control Technology On Nox Emissions - Preprint, Amber L. Gurecki Allen, Andrew R. Colman, Max D. Sommer, William D. Waddoups, Darrell B. Sonntag
FEAT Publications
Pre-print manuscript.
Abstract
This study examines the effect of aging and deterioration on NOx emissions from heavy-duty diesel trucks (HDDTs) with different emission control technologies, including Engine Control only, exhaust gas recirculation (EGR), and selective catalytic reduction (SCR). In-use tailpipe emissions were measured from 12,023 HDDTs from 13 roadside measurement campaigns conducted in California and Utah between 2008 and 2024. Vehicle registration records and the Environmental Protection Agency’s (EPA) engine certification database were used to identify engine NOx control technology. At younger ages, SCR-equipped HDDTs generally emitted significantly less NOx than non-SCR-equipped HDDTs. However, after several years …
Survey Data For Decision Support Tool Development With A Focus On Emerging Design Spaces, Tyson Humphrey, Chris Mattson, Michael L. Anderson, Colin C. Engebretsen
Survey Data For Decision Support Tool Development With A Focus On Emerging Design Spaces, Tyson Humphrey, Chris Mattson, Michael L. Anderson, Colin C. Engebretsen
ScholarsArchive Data
This dataset contains the survey responses and PASE matrix used to support the derivation of nine development principles for decision support tools in emerging design spaces. The survey captures observations from a multidisciplinary DST development team, while the PASE matrix documents relationships among desired DST outcomes, architecture strategies, effects, and supporting literature.
A Square Peg In A Round Hole: Academic Review And Exhibitions, Cory L. Nimer, Megan E. Frost
A Square Peg In A Round Hole: Academic Review And Exhibitions, Cory L. Nimer, Megan E. Frost
Faculty Publications
Academic libraries increasingly use exhibitions as scholarly communication, yet conventional peer-review models rarely account for their collaborative, interdisciplinary nature. Museums and other GLAM institutions have developed standards addressing exhibition goals, audiences, interpretation, attribution, access, and visitor engagement, offering a useful foundation for academic library practice. At Brigham Young University, a library task force examined peer-review models across disciplines and adapted museum standards into a policy for evaluating exhibitions as scholarship in retention and promotion processes. Approved in January 2025, the policy was first applied to By Study and By Faith: 150 Years of BYU, an exhibition developed for the …
Nepal Brick Dust And Silica Exposure 2023-2025 Combined Data, Brinly Openshaw, Willow A. Call, Parker D. Willis, Claire Owens, Gregory L. Snow, Seshananda Sanjel, James D. Lecheminant, Neil E. Peterson, Andrew J. South, Clifton B. Farnsworth, Jayson Gifford, Scott C. Collingwood, James D. Johnston
Nepal Brick Dust And Silica Exposure 2023-2025 Combined Data, Brinly Openshaw, Willow A. Call, Parker D. Willis, Claire Owens, Gregory L. Snow, Seshananda Sanjel, James D. Lecheminant, Neil E. Peterson, Andrew J. South, Clifton B. Farnsworth, Jayson Gifford, Scott C. Collingwood, James D. Johnston
ScholarsArchive Data
A quantitative, cross-sectional study was conducted over an approximately three-year period with sample collection events occurring March 13-21, 2023, March 17 – 23, 2024, and February 18 – 26, 2025. Samples were taken across 4 brick kilns in Bhaktapur, Nepal, including Kiln 1 in 2023, Kiln 2 in 2024, and Kilns 3 and 4 in 2025. Participants (N = 248) were recruited by convenience sampling from kiln 1 (n = 49), kiln 2 (n = 70), kiln 3 (n = 69), and kiln 4 (n = 60).
Developing A Protocol To Obtain Source Directivity Of Hydroacoustic Transducers In A Water Tank, Benjamin White
Developing A Protocol To Obtain Source Directivity Of Hydroacoustic Transducers In A Water Tank, Benjamin White
Undergraduate Honors Theses
This thesis describes the formulation and application of a methodology designed to obtain source directivity of hydroacoustic transducers in the BYU Underwater Acoustics Laboratory. Piezoelectric transducers are presented, and common methodologies to measure their directivity are reviewed. The schematics of the BYU Underwater Acoustics Lab are explained, including the use of positioning robots to position the source-receiver pair in the measurement chain. The protocol is divided into different configurations comprising various source-receiver orientations. The processes of time gating, calculation of OASPL, and plotting onto directional axes are described. The protocol is tested across four different alternative configurations, including one method …
Data For Advocacy Intention Using Pmt, Alice Ann Crandall
Data For Advocacy Intention Using Pmt, Alice Ann Crandall
ScholarsArchive Data
This includes the deidentified data and code for the article Advocacy Intention Across Politically Sensitive Health Issues: A Cross-Sectional Study Using Protection Motivation Theory
Welcome To Our Charity Bazaar, Leslee Thorne-Murphy, Maggie Kopp
Welcome To Our Charity Bazaar, Leslee Thorne-Murphy, Maggie Kopp
Faculty Publications
Catalog for the 2017-2018 exhibit at L. Tom Perry Special Collections, BYU Library. Charity bazaars were a product of a massive nineteenth-century philanthropic undertaking in the United Kingdom, as private citizens attempted to respond to the social ills created by a rapidly industrializing economy. Bazaars combined the entertainment value of a social gathering and the fun of a town fair, with the moral earnestness of philanthropic work. Typically organized by women, these bazaars offered handmade goods for sale, raising funds for numerous local and national charitable causes. The exhibit showcases the history and print culture of the charity bazaar, from …
Genai And The Self Represented Litigant, Kristen Clarke Kellems, Kristen Clarke Kellems, Kristen Clarke Kellems
Genai And The Self Represented Litigant, Kristen Clarke Kellems, Kristen Clarke Kellems, Kristen Clarke Kellems
Faculty Publications
Generative AI is making it easier for self-represented litigants to produce polished legal documents, but easier filing does not necessarily lead to better outcomes. This presentation examines how AI may expand access to courts while increasing weak filings, early dismissals, and burdens on the legal system.
The session reviews attorneys’ duties of technological competence, confidentiality, supervision, and citation verification. It also distinguishes general-purpose AI from legal research tools. Using a Utah third-party custody and guardianship problem, the presentation compares several tools based on statutory accuracy, legal comprehension, treatment of case law, and completeness. The results show that identifying controlling cases …
Parental Perceptions Of Censorship In Utah: Working Paper, Rachel L. Wadham, Dallyn Edmunds
Parental Perceptions Of Censorship In Utah: Working Paper, Rachel L. Wadham, Dallyn Edmunds
Faculty Publications
The rapid rise of book challenges and removals in U.S. school libraries has increasingly been justified through appeals to parental rights, yet relatively little research has explored what parents themselves believe about censorship and book removal. This exploratory qualitative study examined Utah parents’ perceptions of censorship in school libraries, the kinds of content they believe should be restricted, and the reasoning underlying those beliefs. Using a grounded theory-informed thematic analysis approach, data were collected through a survey of 319 Utah parents with children enrolled in public schools. The survey combined closed-ended and open-ended questions, allowing participants to articulate their views …
Myths, Risks, And Realities Of Floppy Disk Preservation, Tyler Thorsted, Leontien Talboom, Julianna Barrera-Gomez, Ross Spencer
Myths, Risks, And Realities Of Floppy Disk Preservation, Tyler Thorsted, Leontien Talboom, Julianna Barrera-Gomez, Ross Spencer
Faculty Publications
Floppy disks remain vital for accessing early digital collections, yet online forums and blogs circulate many untested myths around these carriers. This paper examines common claims about reading disks; handling, cleaning, storage and media fragility; evaluating them in the context of contemporary workflows. Drawing on practical experience, targeted testing, and collaboration with conservation experts, we distinguish between theoretical risks and real-world workflows. By situating online advice within our own preservation practice, we provided a grounded perspective that helps preservation practitioners navigate legacy media.
Data Management Fundamentals, Maggie Marchant, Paul Kj Robbins, Adam Griggs, Ellen Amatangelo
Data Management Fundamentals, Maggie Marchant, Paul Kj Robbins, Adam Griggs, Ellen Amatangelo
Library Scholarly Communications Workshops
This session will teach good principles of data management including:
- Data management lifecycle
- File naming conventions
- Readme files and data documentation
- Data formats and storage
The Impact Of Partner Support On Vaginismus Treatment Outcomes: A Mixed Methods Study, Anna R. Ames, Alisha H. Redelfs, Nana Mensah
The Impact Of Partner Support On Vaginismus Treatment Outcomes: A Mixed Methods Study, Anna R. Ames, Alisha H. Redelfs, Nana Mensah
ScholarsArchive Data
A mixed-methods design was used to gain a nuanced understanding of how partner support affects the experiences of people with vaginismus.
Study aim: To guide partners of people with vaginismus in understanding how they can best help their partners with their vaginismus experience.
- Quantitative Data: cross-sectional survey to reveal correlations in the relationship between vaginismus treatment outcomes and partner support [Available]
- Qualitative Data: Individual interviews to explore specific ways that people with vaginismus receive, or want to receive, support from their partners and the significance that they place on partner support [Not Available]
Survey Data
Survey participants were recruited in …
Temperature Predictions With Zncuins/Zns Quantum Dots, Reu/Fri Program Physics And Astronomy, Amber Banks
Temperature Predictions With Zncuins/Zns Quantum Dots, Reu/Fri Program Physics And Astronomy, Amber Banks
Student Works
For hundreds of years, humans have built thermometers based on the principles of thermal expansion and contraction. In the modern world, there is a need to scale down our thermometers to monitor cellular reactions, both within the human body and within artificial organ chips. Lewis et al. (2020) introduces a nanoscale thermometer based on the thermal expansion of CdTe quantum dots. When ex panded, these dots exhibit systematic changes in photoluminescence (PL) which are recognized by a neural network as an increase in temperature. Our research builds upon the framework of Lewis et al. (2020), testing its feasibility with ZnCuInS/ZnS …
God's Will Or Man's? The Power Of Religious Rhetoric In Shaping Wartime Domestic Policy Preferences, Claire E. Brimhall
God's Will Or Man's? The Power Of Religious Rhetoric In Shaping Wartime Domestic Policy Preferences, Claire E. Brimhall
Undergraduate Honors Theses
How do individuals represent their religious beliefs in the political sphere? Is this impacted by levels of conflict in a given society? In times of war, people of faith often rally behind leaders and policies that diverge from the values upheld by their religious institutions. In fact, in many such cases, religious affiliation and church attendance are among the strongest predictors of support for these political actors.
This thesis examines two such cases where religious voters support policies that contradict the moral teachings of their faith, advancing a theory that a state’s appeals to religion can fundamentally reshape how believers …
Interpreting Title Vi: Translation Theory And The Making Of Language Policy, Olivia A. Allred
Interpreting Title Vi: Translation Theory And The Making Of Language Policy, Olivia A. Allred
Undergraduate Honors Theses
Title VI of the Civil Rights Act provides the primary statutory basis for the development of policies supporting language access. Rather than explicitly requiring institutions to accommodate individuals with limited English proficiency (LEP), the statute establishes a broad prohibition against discrimination based on race, color, and national origin. This thesis examines the process through which that broad statutory mandate has been interpreted and applied to specific language-access policies.
To elucidate the application of language access polices at the federal level, this analysis focuses on three landmark Supreme Court decisions concerning Title VI: Lau v. Nichols, Regents of the University …
シオンからの便り(2), Ryuichi Inouye
シオンからの便り(2), Ryuichi Inouye
Spiritual Proficiency
長年教会の教育部門に携わり、とりわけ若い世代との関わりを大切にしてこられた井上兄弟は、豊かな福音知識だけでなく、日々の小さな出来事にも心を配る「実践の人」として知られています。伝道会長、地区代表、神殿会長など、多岐にわたる奉仕を通して培われた独自の視点が、本書のいたるところに息づいています。
収録されているメッセージの数々は、井上兄弟が率いる「シオンのグループ」へ宛てて書き送られた記事を、ほぼ原文のまま年代順にまとめたものです。1つ1つが2~3分で読める分量なので、まずは通読して全体の流れをつかみ、その後トピックごとに立ち止まりながら、日々の生活に少しずつ取り入れていただければと思います。今後は音声やビデオ、エッセイなど多様な形での展開も計画しており、本資料はBYU ScholarsArchiveの「Spiritual Proficiency」セクションに掲載されます。皆さんご自身の霊的な経験も、ぜひお寄せください。
編集者:有泉芳彦
シオンからの便り(4), Ryuichi Inouye
シオンからの便り(4), Ryuichi Inouye
Spiritual Proficiency
長年教会の教育部門に携わり、とりわけ若い世代との関わりを大切にしてこられた井上兄弟は、豊かな福音知識だけでなく、日々の小さな出来事にも心を配る「実践の人」として知られています。伝道会長、地区代表、神殿会長など、多岐にわたる奉仕を通して培われた独自の視点が、本書のいたるところに息づいています。
収録されているメッセージの数々は、井上兄弟が率いる「シオンのグループ」へ宛てて書き送られた記事を、ほぼ原文のまま年代順にまとめたものです。1つ1つが2~3分で読める分量なので、まずは通読して全体の流れをつかみ、その後トピックごとに立ち止まりながら、日々の生活に少しずつ取り入れていただければと思います。今後は音声やビデオ、エッセイなど多様な形での展開も計画しており、本資料はBYU ScholarsArchiveの「Spiritual Proficiency」セクションに掲載されます。皆さんご自身の霊的な経験も、ぜひお寄せください。
編集者:有泉芳彦
シオンからの便りシリーズへのリンク, Ryuichi Inouye
シオンからの便りシリーズへのリンク, Ryuichi Inouye
Spiritual Proficiency
長年教会の教育部門に携わり、とりわけ若い世代との関わりを大切にしてこられた井上兄弟は、豊かな福音知識だけでなく、日々の小さな出来事にも心を配る「実践の人」として知られています。伝道会長、地区代表、神殿会長など、多岐にわたる奉仕を通して培われた独自の視点が、本書のいたるところに息づいています。
収録されているメッセージの数々は、井上兄弟が率いる「シオンのグループ」へ宛てて書き送られた記事を、ほぼ原文のまま年代順にまとめたものです。1つ1つが2~3分で読める分量なので、まずは通読して全体の流れをつかみ、その後トピックごとに立ち止まりながら、日々の生活に少しずつ取り入れていただければと思います。今後は音声やビデオ、エッセイなど多様な形での展開も計画しており、本資料はBYU ScholarsArchiveの「Spiritual Proficiency」セクションに掲載されます。皆さんご自身の霊的な経験も、ぜひお寄せください。
編集者:有泉芳彦
シオンからの便り(1), Ryuichi Inouye
シオンからの便り(1), Ryuichi Inouye
Spiritual Proficiency
長年教会の教育部門に携わり、とりわけ若い世代との関わりを大切にしてこられた井上兄弟は、豊かな福音知識だけでなく、日々の小さな出来事にも心を配る「実践の人」として知られています。伝道会長、地区代表、神殿会長など、多岐にわたる奉仕を通して培われた独自の視点が、本書のいたるところに息づいています。
収録されているメッセージの数々は、井上兄弟が率いる「シオンのグループ」へ宛てて書き送られた記事を、ほぼ原文のまま年代順にまとめたものです。1つ1つが2~3分で読める分量なので、まずは通読して全体の流れをつかみ、その後トピックごとに立ち止まりながら、日々の生活に少しずつ取り入れていただければと思います。今後は音声やビデオ、エッセイなど多様な形での展開も計画しており、本資料はBYU ScholarsArchiveの「Spiritual Proficiency」セクションに掲載されます。皆さんご自身の霊的な経験も、ぜひお寄せください。
編集者:有泉芳彦
シオンからの便り(3), Ryuichi Inouye
シオンからの便り(3), Ryuichi Inouye
Spiritual Proficiency
長年教会の教育部門に携わり、とりわけ若い世代との関わりを大切にしてこられた井上兄弟は、豊かな福音知識だけでなく、日々の小さな出来事にも心を配る「実践の人」として知られています。伝道会長、地区代表、神殿会長など、多岐にわたる奉仕を通して培われた独自の視点が、本書のいたるところに息づいています。
収録されているメッセージの数々は、井上兄弟が率いる「シオンのグループ」へ宛てて書き送られた記事を、ほぼ原文のまま年代順にまとめたものです。1つ1つが2~3分で読める分量なので、まずは通読して全体の流れをつかみ、その後トピックごとに立ち止まりながら、日々の生活に少しずつ取り入れていただければと思います。今後は音声やビデオ、エッセイなど多様な形での展開も計画しており、本資料はBYU ScholarsArchiveの「Spiritual Proficiency」セクションに掲載されます。皆さんご自身の霊的な経験も、ぜひお寄せください。
編集者:有泉芳彦
Developing An Object Level Understanding Of Sine And Cosine As Ratios And A Coherent Trigonometry, Jeffrey Peter Nair
Developing An Object Level Understanding Of Sine And Cosine As Ratios And A Coherent Trigonometry, Jeffrey Peter Nair
Theses and Dissertations
Solving right-triangle problems as well as integrating right-triangle and circular trigonometry into a coherent understanding are documented challenges for students. Prior research has deeply investigated students constructing ratio meanings for sine and cosine using a circle-first approach, which then can be extended to right triangles. Also, past work has separately documented distinct meanings that are useful for sine and cosine, in addition to the ratio meaning, including as lengths in a unit circle and coordinate points. This study took these existing ideas and put them together into one possible developmental progression, based on APOS theory, where students can learn length, …
Actionable Hydrologic Data To Information With National Water Model-Based Derived Dataset, Cutting-Edge Data Services, And Agentic Ai System, Sujan Chandra Mondol
Actionable Hydrologic Data To Information With National Water Model-Based Derived Dataset, Cutting-Edge Data Services, And Agentic Ai System, Sujan Chandra Mondol
Theses and Dissertations
Hydrologic data are the cornerstone of many complex hydrologic research and operational workflows that produce useful hydrologic information for water resources decision-making, flood risk communication, and water availability implications. The National Water Model (NWM) is a valuable source of hydrologic data, particularly for its extended coverage of unmonitored streams and the large-scale continuity of hydrologic processes. Precomputed secondary datasets derived from this simulated data, such as streamflow indices, can improve operational efficiency through thresholding. Disseminating the data through modern technologies, such as application programming interfaces, is required for ready integration into applications. However, if extraction requires an intermediate service, there …
"Tithing Is An Insurance Premium": A Framing Analysis Of Speaker Innovation And Diachronic Trends In Latter-Day Saint Religious Discourse, Reid Empey
Theses and Dissertations
Religious language relies on shared metaphor and frames that contextualize religious experience and practice. Current approaches to frame semantics (Fillmore 1982) and cognitive metaphor (Lakoff & Johnson 1980) lend important insight into religious language, particularly in describing the role that figurative language serves in a religious speech community. However, a vital component of many religious speech communities is the presence of and engagement with a scriptural canon, which often contains metaphorical and framing language that religious speakers can directly reference. Yet, past conceptualizations of speech communities have not accounted for this engagement with a shared canon. To illustrate the role …
Synthetic Strategies For Bioactive Peptides: From Aggregation Inhibitors To The Total Synthesis Of Tunicyclin C, Stephanie Graciela Garcia Morin
Synthetic Strategies For Bioactive Peptides: From Aggregation Inhibitors To The Total Synthesis Of Tunicyclin C, Stephanie Graciela Garcia Morin
Theses and Dissertations
In Alzheimer's disease (AD), a brain protein called "tau" abnormally clumps and forms neurofibrillary tangles (NFTs), causing damage to brain cells. Ac-PHF6-NH2 is a hexapeptide segment of tau protein that plays a dominant role in tau aggregation and is used as a model to design tau protein aggregation inhibitors. In this research we synthesized four dehydroamino acid (□AA) containing PHF6 analogues with △Abu (derived from L-threonine) and △Val (derived from □-OH-Valine) at position 2 or 3 via dehydrations or azlactone ring-openings as key reactions. We evaluated their proteolytic resistance, ability to inhibit aggregation of PHF6, and impact on the morphology …