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Articles 97051 - 97080 of 5207136
Full-Text Articles in Entire DC Network
Muslim-Based Parties And The Strategic Use Of Polarization In Indonesia’S Multiparty Politics After 2014, Ari Ganjar Herdiansah, Raden Widya Setiabudi Sumadinata, Aliyuna Pratisti
Muslim-Based Parties And The Strategic Use Of Polarization In Indonesia’S Multiparty Politics After 2014, Ari Ganjar Herdiansah, Raden Widya Setiabudi Sumadinata, Aliyuna Pratisti
Jurnal Wacana Politik
The article explores how Indonesian Muslim-based parties are structurally responding to, and using, post-2014 polarization in coalition politics through party institutionalization. Party institutionalization is understood as the mediator that shapes how polarization results in coalition formation, internal organizational dynamics, and electoral performance. A comparative case study of PKB, PKS, PAN, and PPP is covered here, based on interviews with party elites and activists for Islamic organizations, along with secondary sources, electoral reports, and media coverage. Results indicate patterned variation across parties. PKB and PKS, with more cohesive constituencies and stronger organizational capacity, have been able to better exploit the impact …
Prabowo’S Independent Active Foreign Policy On Palestine And Its Global Implications, Syafiuddin Fadlillah, Ujang Komarudin
Prabowo’S Independent Active Foreign Policy On Palestine And Its Global Implications, Syafiuddin Fadlillah, Ujang Komarudin
Jurnal Wacana Politik
This study discusses the implementation of Indonesia’s free and active foreign policy under President Prabowo Subianto concerning the Palestinian issue and its implications for Indonesia’s global role. The principle of Indonesia’s free and active foreign policy serves as the foundation for determining the direction of its foreign policy, particularly regarding the Israel–Palestine conflict. This research employs a qualitative method using Rosenau’s Foreign Policy Analysis theory to analyze the domestic and international factors influencing Indonesia’s foreign policy decisions, and interviews with experts. The findings indicate that President Prabowo reaffirmed his commitment to Palestinian independence through active diplomacy at the United Nations …
Digitalization And Power In Southeast Asia: Rethinking Democracy And Development, Taqiya Arini Putri, Hamzah Turmudi
Digitalization And Power In Southeast Asia: Rethinking Democracy And Development, Taqiya Arini Putri, Hamzah Turmudi
Jurnal Wacana Politik
Digitalization has become an inevitable driver of Southeast Asia’s economic development, simultaneously reshaping policy frameworks and reconfiguring regional power dynamics. Control over and access to digital infrastructure not only influence the distribution of power but also determine the extent to which digital transformation contributes to equitable and sustainable growth. This study, grounded in the theoretical lens of power relations, explores how digitalization initiatives intersect with political agendas and economic trajectories in the region. Methodologically, the research employs a literature-based analysis that conceptualizes digitalization as a non-human actor interacting with human agency in shaping development outcomes. The findings highlight that technological …
Integrating Zotero With Your Writing: From Research To Publication For Pediatric Fellows, Evelyn Wang
Integrating Zotero With Your Writing: From Research To Publication For Pediatric Fellows, Evelyn Wang
HSLIC Faculty and Staff Instructional Resources
This Pediatric Fellows workshop introduces practical skills for integrating Zotero into research and writing workflows, from managing references to generating citations and bibliographies. Topics include installing and configuring Zotero and the Zotero Connector, collecting and organizing references with collections, tags, and PDFs, inserting citations and bibliographies in Microsoft Word and Google Docs, managing PDFs and annotations, and using advanced features such as sync, collaboration, custom citation styles, and ZoteroBib.
Condensation Clouds In Substellar Atmospheres With Virga, Natasha E. Batalha, Caoimhe M. Rooney, Channon Visscher, Sarah E. Moran, Mark S. Marley, Aditya R. Sengupta, Sven Kiefer, Matt G. Lodge, James Mang, Caroline V. Morley, Sagnick Mukherjee, Jonathan J. Fortney, Peter Gao, Nikole K. Lewis, L. C. Mayorga, Logan A. Pearce, Hannah R. Wakeford
Condensation Clouds In Substellar Atmospheres With Virga, Natasha E. Batalha, Caoimhe M. Rooney, Channon Visscher, Sarah E. Moran, Mark S. Marley, Aditya R. Sengupta, Sven Kiefer, Matt G. Lodge, James Mang, Caroline V. Morley, Sagnick Mukherjee, Jonathan J. Fortney, Peter Gao, Nikole K. Lewis, L. C. Mayorga, Logan A. Pearce, Hannah R. Wakeford
Faculty Work Comprehensive List
Here we present an open-source cloud model for substellar atmospheres, called Virga. The Virga-v0 series has already been widely adopted in the literature. It is written in Python and has heritage from the A. S. Ackerman & M. S. Marley model (often referred to as eddysed), used to study clouds on both exoplanets and brown dwarfs. In the development of the official Virga-v1 we have retained all the original functionality of eddysed and updated/expanded several components, including the back-end optical constant data, calculations of the Mie properties, available condensate species, saturation vapor pressure curves, and formalism for fall speed calculations. …
Adversarial Comparativism: The Role Of Emotion In United States–China Comparative Law Projects, Matthew S. Erie
Adversarial Comparativism: The Role Of Emotion In United States–China Comparative Law Projects, Matthew S. Erie
Scholarly Articles in Law Reviews & Journals
Contemporary comparative law operates across a landscape riven by protectionism, nationalism, and securitization, all of which complicate comparative law projects. Nowhere is this more evident than in the U.S-China relationship, the most important bilateral relationship in the world. Despite economic “delinking,” the U.S. and Chinese legal systems are interacting more than ever; however, how this interaction works is poorly understood. This Article proposes “adversarial comparativism” to explain this dynamic. It is an approach to comparative law and politics that includes different modalities: competition, aggressiveness, transactionalism, misunderstanding, opportunism, and gaslighting. Many of these are underpinned by emotion. As such, while this …
Radionuclide-Stimulated Dynamic Therapy Induces Complementary Immunogenic Necroptosis And Apoptosis Cancer Cell Death Pathways, Christopher Egbulefu, Kvar Black, Xinming Su, Partha Karmakar, Lemoyne Habimana-Griffin, Julie Prior, Alex Zheleznyak, Baogang Xu, Yalin Xu, Alison Esser, Matthew Mixdorf, Evan Moss, Brad Manion, Cody Hongsermeier, Nisha Gamadia, Nicole Blasi, Luke Stallings, Chidube Alagbaoso, Nathan Reed, Matthew M Gubin, Chieh-Yu Lin, Robert Schreiber, Katherine Weilbaecher, Samuel Achilefu
Radionuclide-Stimulated Dynamic Therapy Induces Complementary Immunogenic Necroptosis And Apoptosis Cancer Cell Death Pathways, Christopher Egbulefu, Kvar Black, Xinming Su, Partha Karmakar, Lemoyne Habimana-Griffin, Julie Prior, Alex Zheleznyak, Baogang Xu, Yalin Xu, Alison Esser, Matthew Mixdorf, Evan Moss, Brad Manion, Cody Hongsermeier, Nisha Gamadia, Nicole Blasi, Luke Stallings, Chidube Alagbaoso, Nathan Reed, Matthew M Gubin, Chieh-Yu Lin, Robert Schreiber, Katherine Weilbaecher, Samuel Achilefu
Faculty, Staff and Student Publications
Radionuclide-stimulated dynamic therapy (RaST) utilizes Cerenkov-radiating radiopharmaceuticals to activate light-sensitive drugs and materials, generating reactive oxygen species (ROS) that inhibit cancer progression. However, the underlying cell death mechanisms are not fully understood. Using ROS-regenerative nanophotosensitizers coated with a tumor-targeting transferrin-titanocene complex and radiolabeled 2-fluorodeoxyglucose, we found that RaST induced apoptosis and necroptosis, characterized by the activation of RIPK-1, RIPK-3, nuclear factor kappa B, and mixed lineage kinase domain-like pseudokinase, leading to membrane permeabilization, cytokine release, and the expression of immunogenic damage-associated molecular patterns. In immune-deficient breast tumor-bearing mice with adequate stroma and growth factors, RaST did not prevent tumor growth …
Comprehensive Metabolic Profiling Across Five Lifespan Stages In Murine Hippocampus And Cortex Reveals Sex-Related Variation In Age-Related Cognitive Decline, Xi Long, Wuping Liu, Changhan Chen, Qi Guo, Yidan Wang, Yujin Zhang, Yang Xia
Comprehensive Metabolic Profiling Across Five Lifespan Stages In Murine Hippocampus And Cortex Reveals Sex-Related Variation In Age-Related Cognitive Decline, Xi Long, Wuping Liu, Changhan Chen, Qi Guo, Yidan Wang, Yujin Zhang, Yang Xia
Faculty, Staff and Student Publications
This study employs Barnes maze behavioral assessments, untargeted liquid chromatography-mass spectrometry metabolomics, and 13C6-glucose isotopic tracing to systematically investigate cognitive function and metabolic profiles in hippocampal and cortical tissues of male and female mice across five distinct age-ranges. Behavioral analyses reveal significant cognitive decline in both sexes by 16-months-of-age, with females exhibiting more severe impairment by 23-months, demonstrating a sex-related variation. 13C6-glucose tracing analyses reveals that glucose is rapidly and preferentially metabolized toward the Tricarboxylic acid cycle over glycolysis and the pentose phosphate pathway (PPP), with metabolism rates increasing from juvenility to meet developmental demands and maintaining homeostasis into pre-elderly. …
Successful Bacteriophage Treatment Of A Recalcitrant Intra-Abdominal Infection Caused By Multi-Drug-Resistant Pseudomonas Aeruginosa In A 2-Year-Old Child, Ishminder Kaur, Kristina Adachi, Nanda Ramachandar, Austin L Terwilliger, Anthony Maresso, Robert S Venick, Suzanne V Mcdiarmid, John S Bradley
Successful Bacteriophage Treatment Of A Recalcitrant Intra-Abdominal Infection Caused By Multi-Drug-Resistant Pseudomonas Aeruginosa In A 2-Year-Old Child, Ishminder Kaur, Kristina Adachi, Nanda Ramachandar, Austin L Terwilliger, Anthony Maresso, Robert S Venick, Suzanne V Mcdiarmid, John S Bradley
Faculty, Staff and Students Publications
Antimicrobial resistance is life-threatening to complex pediatric patients who receive multiple courses of broad-spectrum antibiotics. Bacteriophages offer a safe treatment alternative when our antibiotic armamentarium is no longer sufficient. We describe successful use of bacteriophage therapy on a patient with a recalcitrant Pseudomonas aeruginosa infection after receiving a multi-organ transplant.
An Open-Source Application For Self-Service, Health Insurance And Portability Accountability Act-Compliant Geocoding., Harpreet Gill, Kevin Power, Catherine Jackson, Jared Johnson, Matthew Llewelyn, Kushal Vallambhatla, Natalie J. Kane, Jeffrey Thompson, Kelechi Anuforo, Cole Brokamp, Mark A. Hoffman
An Open-Source Application For Self-Service, Health Insurance And Portability Accountability Act-Compliant Geocoding., Harpreet Gill, Kevin Power, Catherine Jackson, Jared Johnson, Matthew Llewelyn, Kushal Vallambhatla, Natalie J. Kane, Jeffrey Thompson, Kelechi Anuforo, Cole Brokamp, Mark A. Hoffman
Manuscripts, Articles, Book Chapters and Other Papers
OBJECTIVE: DeGAUSS is a privacy-preserving application that ingests addresses and generates output that includes latitude, longitude, census tract, deprivation index and drive times to major hospitals. The application uses a complex command line interface and a container management platform to perform analysis. Our objective was to develop a user-friendly DeGAUSS-based application that simplifies place-based analysis. We also enabled automated geomarker generation by providing an API modality to DeGAUSS.
METHODS: We developed a self-service platform based on the DeGAUSS application. The application was linked to user authentication platforms. The self-service application can be implemented as an API, enabling high-volume geocoding transactions. …
Underrepresented And Understudied: Exploring The Lived Experiences Of African American Women In Policing, Brenda Goss Andrews
Underrepresented And Understudied: Exploring The Lived Experiences Of African American Women In Policing, Brenda Goss Andrews
Walden Dissertations and Doctoral Studies
African American women are underrepresented in policing and understudied in the research. Grounded in Collins’ Black feminist thought, whose theme seeks to empower Black women to speak in their authentic voices, this qualitative phenomenological study explored the lived experiences of 12 African American female officers from Midwest departments. It examined how the intersection of race and gender shaped their workplace realities. The purpose of the study was to gain perspectives from the participants on strategies to recruit and retain African American female officers. Historically, policing has been a gendered and hypermasculine profession, making it difficult for African American female officers …
Navigating Blended Family Dynamics: Lived Experiences Of Newly - Married Black American Couples With Children, Nichole King-Price
Navigating Blended Family Dynamics: Lived Experiences Of Newly - Married Black American Couples With Children, Nichole King-Price
Walden Dissertations and Doctoral Studies
Remarriage offers the opportunity to create new family structures, giving individuals second chances to forge meaningful connections and develop new family dynamics. This study involved investigating the experiences of newly-married Black American couples with children as they faced challenges inherent to blended family dynamics. The objective was to understand how these families navigated the complexities of integrating different family systems during their formative years. Using a basic qualitative research design, the study was guided by Bowen’s family systems theory, which emphasizes how individuals construct knowledge within their socioemotional contexts. A convenience sample of nine spouses from blended families was purposefully …
Effective Leadership Strategies That Enhance Banking Employees’ Productivity, Biljana Matevska
Effective Leadership Strategies That Enhance Banking Employees’ Productivity, Biljana Matevska
Walden Dissertations and Doctoral Studies
Ineffective leader-follower relationships in banks can negatively affect productivity. Branch bank leaders in New Jersey are concerned that low productivity reduces the quality of service provided to clients. Based on leader-member exchange theory, the purpose of this qualitative pragmatic inquiry project is to identify and explore effective strategies that some leaders in the banking industry in New Jersey use to build leader-follower relationships for increasing and sustaining worker productivity. Participants were six bank managers in New Jersey who had implemented strategies. Data were collected through semistructured interviews and a review of publicly available industrial documents, and three themes were identified …
Narratives Of First-Generation Mexican American Bilingual Licensed Counselors, Marleny Soriano
Narratives Of First-Generation Mexican American Bilingual Licensed Counselors, Marleny Soriano
Walden Dissertations and Doctoral Studies
Despite the growing demand for mental health services in Spanish, bilingual counselors are often ill-equipped to provide services in Spanish and frequently enter state-required supervised licensure without adequate training or opportunities for clinical supervision to support their growth as bilingual counseling professionals. The purpose of this qualitative narrative inquiry was to answer the research question: What are the narratives of first-generation Mexican American bilingual counselors during supervised licensure? Guided by Anzaldua’s Borderlands Theory as a conceptual framework, data were collected from eight participants through semi-structured virtual interviews and analyzed using thematic analysis. Findings revealed four themes mirroring the stages of …
Overseas Military Transition And Post-Military Job Retention, Chea Hale-Hernandez
Overseas Military Transition And Post-Military Job Retention, Chea Hale-Hernandez
Walden Dissertations and Doctoral Studies
Adjustment from military life to the corporate or civilian world can be challenging for some individuals who have served in the armed forces. The purpose of this qualitative phenomenological study was to explore the lived experiences of U.S. military veterans transitioning from overseas service to civilian employment and to identify the factors contributing to long-term job retention. The military transition theory and turnover contagion theory grounded this study. The participants consisted of 20 male veterans representing the U.S. Army, Navy, Air Force, and Army National Guard in Dayton, Ohio. Data were collected using semistructured interviews and public documents. Two themes …
Exploring Effective Strategies For Optimizing Financial Investments In Healthcare Technology, Bashir Adeniyi Agboola
Exploring Effective Strategies For Optimizing Financial Investments In Healthcare Technology, Bashir Adeniyi Agboola
Walden Dissertations and Doctoral Studies
Ineffective optimization of the billions of dollars spent annually on healthcare technology threatens the sustainability of healthcare systems and exacerbates inequities in patient access. Healthcare technology leaders who lack effective investment optimization strategies risk reducing the operational effectiveness of their healthcare system. The purpose of this qualitative, pragmatic inquiry was to explore the effective strategies that healthcare technology leaders use to optimize financial investments in healthcare technology to improve the patient care experience and equitable access to healthcare services. The participants were nine healthcare technology leaders who used optimal financial investment strategies. Data were collected through semistructured interviews and a …
Fort William First Nation People’S Perceptions Of Receiving Nursing Care To Meet Their Wholistic Health Needs, Kara Morriseau
Fort William First Nation People’S Perceptions Of Receiving Nursing Care To Meet Their Wholistic Health Needs, Kara Morriseau
Walden Dissertations and Doctoral Studies
There was limited knowledge of First Nations people’s experiences receiving nursing care to meet their wholistic health needs in Northern Ontario. The purpose of this qualitative interpretive description study, grounded in the two-eyed seeing framework and the Indigenous wholistic theory, was to explore First Nations people’s descriptions of receiving nursing care to meet their wholistic health needs in Northern Ontario. The study took place in the community of Fort William First Nation, a First Nations community in Northern Ontario. With approval from the Chief and Council of Fort William First Nation, semistructured interviews were conducted in person and on Zoom …
Best Practices To Reduce Patient Falls In Skilled Nursing Facilities In Virginia, Kianna J. Tinsley
Best Practices To Reduce Patient Falls In Skilled Nursing Facilities In Virginia, Kianna J. Tinsley
Walden Dissertations and Doctoral Studies
Patient falls in skilled nursing homes highlight the need for effective, evidence-based strategies to reduce falls and improve residents' quality of life. The purpose of this integrative review was to identify administrative strategies for reducing patient falls within skilled nursing facilities. The review question centered on the most effective strategies and best practices that healthcare administrators can use to reduce patient falls and injuries and increase patient satisfaction. The Donabedian model served as the theoretical framework, providing a strong foundation for evaluating health services and quality of care to reduce patient falls. A comprehensive literature review identified 50 relevant articles, …
Reducing Youth False Confessions With Attorney Presence, Rosa Bowden-Maccalla
Reducing Youth False Confessions With Attorney Presence, Rosa Bowden-Maccalla
Walden Dissertations and Doctoral Studies
Interrogation techniques are influenced by the interrogator's style and the individual being interviewed. Most law enforcement agencies use adult-centered interrogation methods, leading to suboptimal results when working with youth. The research has focused on youth offenders in the interrogation room and the choices they make, often leading to false confessions when an attorney is absent. This suggests that the presence of legal representation helps protect youths' vulnerability, suggestibility, and rights, thereby reducing the likelihood of false confessions. This qualitative collective case study aimed to understand why youth offenders falsely confess by collecting seven anonymous questionnaires from multigender U.S. practicing attorneys …
Managerial Strategies To Increase Employee Retention In The Health Care Industry, Albert Scales Iii
Managerial Strategies To Increase Employee Retention In The Health Care Industry, Albert Scales Iii
Walden Dissertations and Doctoral Studies
Employee turnover remains a significant business concern for Hawaiian health care organizations. Health care organization leaders are concerned about employee retention because of its implications for organizational effectiveness and the continuity of customer care. Grounded in Herzberg’s two-factor theory, the purpose of this qualitative pragmatic inquiry was to identify and explore successful strategies used by eight purposively selected health care leaders in Hawaii to improve employee retention. Thematic analysis of semistructured interview data and public organizational documents revealed six themes: (a) competitive compensation and benefits, (b) professional development and training, (c) recognition and rewards, (d) work–life balance and flexibility, (e) …
Imu-Driven Watch Face With Performance-Optimized Graphics, Gabriela Namie, Teddy Guerrero, Seth Benson, Courtney Cox, Tyler Gough, Mike Humphrey
Imu-Driven Watch Face With Performance-Optimized Graphics, Gabriela Namie, Teddy Guerrero, Seth Benson, Courtney Cox, Tyler Gough, Mike Humphrey
Defensive Publications Series
A smartwatch interface displays dynamic, three-dimensional-like animations which are directly responsive to the user's wrist movements. The system uses data from the watch's Inertial Measurement Unit (IMU) to drive the animation of on-screen graphical elements in real-time. The method includes code-based techniques for simulating visual effects like gradients and for managing element animation to maintain fluid performance (e.g., 30 frames per second) to overcome hardware limitations related to rendering complex graphics and a high number of elements.
Trust Based Intelligent Bidding Mechanism For Selecting Efficient, Highly Rated And Suitable Worker Agents, Aditya Kesarwani, Sushanth Patil, Sunil Pareek
Trust Based Intelligent Bidding Mechanism For Selecting Efficient, Highly Rated And Suitable Worker Agents, Aditya Kesarwani, Sushanth Patil, Sunil Pareek
Defensive Publications Series
A system including a trust-based intelligent bidding mechanism is proposed herein that addresses the critical challenge of selecting an appropriate agent within an agentic artificial intelligence ecosystem, where users and customers often struggle to evaluate agents, resulting in suboptimal outcomes. This innovative system incorporates bidding agents and a trust layer that facilitates the selection of trustworthy agents for user task execution. Thus, the system rapidly and accurately provides users with appropriate worker agents while considering other factors such as cost, ratings, and user feedback.
Unified Multi-Modal Adaptive Caregiving Assistance Platform, Kshitij Suresh Gaikar
Unified Multi-Modal Adaptive Caregiving Assistance Platform, Kshitij Suresh Gaikar
Defensive Publications Series
The present disclosure relates to a unified, multi-modal, adaptive platform configured to monitor and analyze the needs of human infants and domestic pets. The system utilizes a sensing module to capture audio, video, and environmental data, which is processed through a hybrid edge and cloud computing architecture. By employing deep multi-modal data fusion, the system integrates synchronized feature vectors to infer specific subject needs. The platform generates ranked, actionable recommendations for caregivers and incorporates a reinforcement learning feedback loop to personalize suggestions based on subject-specific responses.
Keywords: Caregiving, Multi-modal Data Fusion, Artificial Intelligence, Reinforcement Learning, Infant Monitoring, Pet Monitoring.
Generative Model-Assisted Generation Of Structural Selectors For Web Data Extraction, Jordan Janeiro
Generative Model-Assisted Generation Of Structural Selectors For Web Data Extraction, Jordan Janeiro
Defensive Publications Series
The automated web data extraction can be challenged by time-consuming manual methods and direct data retrieval by generative models that may be unreliable due to outdated training data. A disclosed technique can address these challenges by using a generative model to analyze the document object model of web pages. Instead of extracting data content, the model can identify stable structural patterns containing desired data and can output corresponding selectors, such as cascading style sheets selectors or XPath expressions. This approach, which may involve clustering structurally similar pages before analysis, can separate structural pattern recognition from final value extraction. This process …
Account Risk-Based Watermarking Of Generative Ai Content, Pingping Chen, Meng Ya, Tyler Kress, Jonathan Joa, Chris Xu
Account Risk-Based Watermarking Of Generative Ai Content, Pingping Chen, Meng Ya, Tyler Kress, Jonathan Joa, Chris Xu
Defensive Publications Series
Systems and methods are described that may link a user account's risk profile to the content it generates. The technology can assess account behavior to generate a risk score and can embed corresponding digital watermarks into AI-generated content. For example, an origin watermark may identify the content as AI-generated, while a safety watermark may encode information related to potential risks based on the account's score and the user's prompt. This approach may allow downstream platforms to detect these watermarks, which can enable them to apply context-aware moderation, such as displaying informational labels or providing user-configurable controls, facilitating safety enforcement at …
System For Autonomous Behavioral Verification And Remediation Of Migrated Database Code, Khushmeet Rekhi
System For Autonomous Behavioral Verification And Remediation Of Migrated Database Code, Khushmeet Rekhi
Defensive Publications Series
The migration of database code may result in data corruption when static translation tools do not fully account for behavioral differences between source and target platforms, for example, in rounding or null value handling. A dynamic verification approach can address this. A system may passively observe a legacy database to capture truth vectors, which can be records linking transaction inputs to their verified outputs. Translated code can then be executed in an isolated sandbox environment using these inputs. A semantic comparator may analyze the new output against the legacy output from the truth vector. If a material discrepancy is found, …
Non-Invasive Dielectric Fluid Health Monitoring System, Dhruv S Chaddah, Zaid A Issa, Gowrav Bukkapattana Gururaj, Yaagna Krupal Modi
Non-Invasive Dielectric Fluid Health Monitoring System, Dhruv S Chaddah, Zaid A Issa, Gowrav Bukkapattana Gururaj, Yaagna Krupal Modi
Defensive Publications Series
Proposed herein is a system that integrates high-resolution capacitive, optical, and infrared temperature sensing into a compact, clamp-on module that mounts directly onto a non-metallic coolant tube. Ideally, the clamp-on module can be located at the pump outlet, where fluid temperature, flow, and dielectric properties are most representative of system health. This fully non-invasive approach enables continuous, real-time monitoring without disrupting the cooling loop.
An Improved Process For The Preparation Of Momelotinib Dihydrochloride Monohydrate, Anonymous
An Improved Process For The Preparation Of Momelotinib Dihydrochloride Monohydrate, Anonymous
Defensive Publications Series
The present publication relates to a process for the preparation of Momelotinib dihydrochloride monohydrate, chemically known as N-(cyanomethyl)-4-{2-[4-(morpholin-4-yl) anilino] pyrimidin-4-yl} benzamide dihydrochloride monohydrate (Formula I).
Conscious Ai Thought Origination In Llm, Shreyas Kc, Yu Gu
Conscious Ai Thought Origination In Llm, Shreyas Kc, Yu Gu
Defensive Publications Series
The present disclosure relates to the field of Artificial Intelligence (AI), and more specifically to conscious AI systems integrated with Large Language Models (LLMs) for autonomous ideation and decision-making. The present disclosure introduces a consciousness layer to a fine-tuned LLM, enabling the model to continuously generate candidate topics, rank them using a weighted scoring algorithm, and select the highest-priority topic for ideation. The consciousness layer captures and stores intermediate outcomes, embeddings, agent actions, and metadata, which are vectorized and re-injected into the LLM’s context to maintain continuity. This loop operates without external prompting, emulating humans like spontaneous thought and topic …
Bempedoic Acid: A Novel Lipid-Lowering Pharmacological Agent For The Management Of Dyslipidemia, Hajir Karim Abdul-Husseein
Bempedoic Acid: A Novel Lipid-Lowering Pharmacological Agent For The Management Of Dyslipidemia, Hajir Karim Abdul-Husseein
Maaen Journal for Medical Sciences
Bempedoic acid is a newly discovered a novel lipid-lowering non-statin agent used for the management of dyslipidemiaand the reduction of cardiovascular risk. Its therapeutic mechanism of action is mediated by the inactivation of upstream enzymatic activity of adenosine triphosphate-citrate lyase (ATP -citrate lyase) that implicated in the cholesterol biosynthetic pathway. Clinical studies have reported that the treatment with bempedoic acid alone may reduce LDL-C levels via nearly 20% when compared with placebo, and by up to 38% when administered in combination with ezetimibe. This new drug has showed a satisfactory safety and tolerability profile demonstrated by a minimal level of …