Digital Commons Network^™

Ns5-Targeting Nucleoside Analogs Inhibit Dengue Virus And Other Flaviviruses, Priyanka Bhakt, Swechha Pokharel, Yue Li, Tamanna Srivastava, Jesse Miller, Mark Dittmar, Yongqing Zhu, David Nguyen, Zachary Walter, Kasirajan Ayyanathan, Matthew Tudor, Chenguang Yu, Arnab Chatterjee, Holly Ramage, David Schultz, Sara Cherry

Department of Microbiology and Immunology Faculty Papers

Dengue virus (DENV) is a mosquito-transmitted flavivirus that circulates globally as four distinct serotypes and poses a substantial threat to public health. There are an estimated ~96 million symptomatic infections yearly, including severe cases of dengue fever, underscoring the urgency of identifying effective therapeutics targeting all four serotypes. Nucleoside analogs, which mimic endogenous nucleosides to inhibit viral RNA replication, offer a promising strategy for broad-spectrum antiviral development. Here, we conducted a high-throughput screen of 1,101 nucleoside analogs against DENV serotype 2 (DENV2) in a panel of human cell models, including human epithelial cells, hepatocytes, and fibroblasts. Candidates that were active …

Unravelling Antecedents And Bidirectional Impacts Of Nurse Work Rumination: A Scoping Review To Enhance Nurses’ Well-Being And Improve Nursing Quality, Wenjun Hu, Xiaofeng Xie, Xun Xu, Siying Wei, Ling Zhu, Yawen An

Faculty Research, Scholarly, and Creative Activity

Background Globally, work rumination is a common phenomenon related to nurse burnout. However, most existing studies focus on the single negative impacts of rumination, with less exploration of its dual effects and antecedents. Therefore, comprehensively exploring the effect of nurse work rumination and its influencing factors is crucial for enhancing the accuracy of nursing management. Objectives Identify the antecedents and dual effects of nurse work rumination to deepen understanding of this phenomenon and provide references for formulating interventions that enhance nurses’ well-being and improve the quality of nursing work. Eligibility criteria Included studies were original research articles focusing on work-related …

Regalado V. Hughes Avenue Corp. And The Department Of Housing Preservation And Development Of The City Of New York

All Decisions

In this HP proceeding, the tenant moved for civil contempt and civil penalties against the landlord for failing to comply with a consent order to correct HPD violations, including those for mold and lead-based paint. The court granted the tenant's motion, finding the landlord in civil contempt for non-compliance with the order. The landlord's arguments, including a vague superintendent's affirmation and an unauthenticated D.H.P.D. repair bill, were insufficient to rebut the presumption that violations persisted. The court imposed a $350 per day fine, payable to the tenant, until outstanding "C" and "B" violations are corrected, and referred the calculation of …

State Siting Of Renewable Energy – Preemptive Power Grab Or Power Play?, Sarah Everhart

Duke Environmental Law & Policy Forum

The United States needs more—and cleaner—energy. Experts project that in the near future, the United States will need to significantly increase its electricity generation. Currently, the burning of fossil fuels remains a significant source of power generation in the United States. However, these fossil fuels produce greenhouse gases that are one of the main drivers of the impending and likely disastrous, climate change. Therefore, it has never been more vital to decarbonize the energy sector. However, there are two significant impediments to the deployment of renewable energy: restrictive local siting laws and community opposition.

According to the Sabin Center for …

Offshore Wind In Vertically-Integrated Versus Deregulated Models: Considerations For State Policymakers, Caroline Daniel

Duke Environmental Law & Policy Forum

Energy law scholars and economists have long studied the theoretical differences between vertically-integrated and deregulated models of electricity regulation. Now, diverse regulatory approaches and advances in renewable electricity technology present the opportunity to go beyond the abstract. This case study applies tenets of energy law and economic theory to offshore wind initiatives to concretize lessons of a clean energy transition for state policymakers going forward.

By comparing Virginia’s and New York’s offshore wind ventures, this analysis lends nuance and practicality to otherwise abstract energy regulation principles. These states are leaders in the volatile offshore wind industry, a target for the …

Environmental Law’S Missing Piece: The Right To Nature, Ori Sharon

Duke Environmental Law & Policy Forum

For decades, environmental law has been trapped in a binary value system: it either treats nature instrumentally, as property to be used for human benefit, or views it as intrinsically valuable, deserving protection for its own sake. Both approaches, though ethically powerful, have struggled to deliver consistent and enforceable protections. As ecological crises deepen, this conceptual stalemate is no longer just inadequate—it is dangerous.

This article argues that environmental law remains structurally incomplete. It has overlooked a third category of value—relational value—long recognized in ethics and conservation science but largely absent from legal doctrine. Relational values arise from the lived, …

Journal Staff

Duke Environmental Law & Policy Forum

No abstract provided.

Search Techniques In Pubmed, Kristin Kroger

Library Learn - Complete Video Collection

This recording provides an overview of essential PubMed search techniques to develop a structured search strategy, integrate MeSH terms with keywords, refine and manage results, access full‑text articles, and make use of key My NCBI features to streamline ongoing research.

When Tokenized Real-World Assets Collide With Real World, Biying Cheng, David J. Reiss

Cornell Law Faculty Publications

The city of Detroit filed a public nuisance lawsuit in July of last year in the Michigan Circuit Court for the Third Judicial Circuit against Real Token, its co-founders and 165 affiliated entities, alleging building code and safety violations across over 400 Detroit residential properties.[1] RealT is a blockchain real estate platform that sells fractional interests in individual U.S. rental properties through the issuance of crypto security tokens.

On July 22, the judge issued a temporary restraining order — later converted into a preliminary injunction on Nov. 4 — barring RealT from collecting rent, pursuing evictions without a certificate of …

Stress Management And Resiliency Program For Accelerated Bsn Students In A Dedicated Education Unit, Marcela Alvarez-Lazo

Creating Healthy Work Environments (CHWE)

Background: About 12-25% of newly graduated nurses will leave nursing within the first-year post-graduation. These statistics surrounding nursing retention are alarming and are not expected to improve, as 900,000 nurses are projected to depart from nursing by the year 2027. Addressing the underlying issues are critical in making a real impact to increase retention.

Aim: This quality improvement project aims to integrate a Stress Management and Resiliency. Program for accelerated BSN nursing students. The project aims to apply a CBT-based program to increase the knowledge of principles of stress and resilience for nursing students and preceptors, decrease stress, increase resilience, …

Caregiving Experiences Of Latino And Caucasian Dementia Caregivers Amid Pandemic, Alexis Ross

Creating Healthy Work Environments (CHWE)

More than 6.7 million American older adults are diagnosed with Alzheimer’s and related dementias (Alzheimer’s Association, 2023). Caregivers for community dwelling persons living with dementia (PWD) are usually family members such as a spouse or offspring. Resources such as adult day care centers, in-home supportive services, and family support groups were widely used before the COVID-19 pandemic. Following the California ‘Stay-At-Home’ administrative order during the early pandemic, such necessary support services were forced to close.

The purpose of this study was to identify similarities and differences in caregiving experiences between Latino caregivers and non-Hispanic White caregivers of community dwelling persons …

The Effects Of Patient Care In Relation To Toxic Workplace Environments, Kayla Fitzgerald

Creating Healthy Work Environments (CHWE)

Background: Bullying in the workplace setting is a significant issue that can severely impact one’s career. Bullying can be demonstrated in several forms- such as verbal abuse, isolation, intimidation, and physical harm. Specific to nursing practice, workplace bullying is shown to have negative effects on mental health, patient care, and overall job satisfaction. While there are no definite means that organizations will take complete action towards this ongoing issue, several implementations can be instilled to reduce the incidence of workplace bullying.

Methods: In this project, studies of negative work environments, specifically workplace bullying, and patient care were critiqued and synthesized. …

Exploring The Impact Of Intersectional Identity On Maternal Morbidity/Birth Outcomes Among Afro-Latinas In Florida, Alexa Parra, Cynthia Lebron, Michaela Larson, Yue Pan, Jonell Potter, Hudson Santos

Creating Healthy Work Environments (CHWE)

Background: The “Hispanic/Latina Paradox" is a phenomenon where Latina women and their infants have perinatal and birth outcomes similar to those of White women. This is often seen as a protective mechanism that helps reduce maternal health inequities. However, this paradox overlooks the fact that there are different subgroups of Latina women, including Afro-Latinas, who are often neglected when addressing racial disparities related to perinatal birth outcomes in the US. The intersectionality of multiple minority identities may put Afro-Latinas at a disadvantage in terms of perinatal health outcomes.

Objective: Determine differences in maternal morbidity, including pregnancy-related hypertension and diabetes, and …

Screening For Postpartum Depression At A Suburban Chiropractic Clinic, Emma Stedronsky, Mary Degrote Goering

Creating Healthy Work Environments (CHWE)

Background: The pregnancy and postpartum period are crucial times to evaluate for mental health conditions. The American College of Obstetrics and Gynecology (ACOG) recommends that providers screen for perinatal and postpartum depression (PPD) at least once during pregnancy and once during the postpartum period using a validated screening tool. A chiropractic clinic in the upper Midwestern United States identified an anecdotal increase in mental health concerns in their pregnant and postpartum patient population since the COVID-19 pandemic. This project utilized interprofessional collaboration by implementing PPD screening at a chiropractic office according to the recommended guidelines using the Edinburgh Postnatal Depression …

Lymphatic Pumping Failure In The Arm Precedes Dermal Backflow And Breast Cancer-Related Lymphedema, Melissa B Aldrich, Meghan E Mcwain, Simona F Shaitelman, Rian E Kuhns, John C Rasmussen, Wendy A Woodward, Sarah M Desnyder, Wenyaw Chan, Eva M Sevick-Muraca

The Brown Foundation: Institute of Molecular Medicine

Background

Breast cancer patients who undergo regional nodal irradiation therapy (RNI) following neoadjuvant chemotherapy and mastectomy or lumpectomy with axillary lymph node dissection (ALND) frequently encounter breast cancer-related lymphedema (BCRL). Early detection and treatment can significantly improve outcomes. Previously, near-infrared fluorescence lymphatic imaging (NIRF-LI) detection of dermal backflow, or retrograde lymphatic flow into initial lymphatics, was shown to precede clinical BCRL diagnosis by 8–23 months. Herein, we hypothesize that lymphatic pump failure is responsible for dermal backflow and may be a target to prevent onset of BCRL symptoms.

Methods

Arm lymphatics in 51 patients with locally advanced breast cancer were …

Waiver Of Statutory Employment Rights In The United Kingdom, Hugh Collins

Comparative Labor Law & Policy Journal

The common law endorses the principle of freedom of contract, but, with few exceptions, Parliament has explicitly prevented straightforward waivers of statutory employment rights. Nevertheless, for the sake of promoting settlements of claims by employees, it is surprisingly easy for individual employees to enter into agreements to compromise claims for breach of those rights without appropriate safeguards such as independent advice and freedom from pressure. Moreover, employers’ lawyers have demonstrated considerable ingenuity in finding ways to avoid the application of employment rights either by manipulations of employment status or by seeking contractual agreements on the facts of the case that …

Relaxation Of Mandatory Rules Through Collective And Individual Agreements In Japanese Labour Law, Ryuichi Yamakawa

Comparative Labor Law & Policy Journal

This article analyses the legal situation in Japan regarding the relaxation of or deviation from mandatory regulations in labour law through collective and individual agreements. Although many statutory labour laws in Japan have a mandatory effect over individual employment contracts, several statutory provisions provide that such mandatory regulations can be relaxed through collective agreements under certain circumstances, as is the case in other industrialised countries. However, Japan’s situation is unique insofar as the relaxation is permissible through collective agreements concluded by non-union (individual) representatives of a majority of employees in the absence of union representatives who have been elected by …

Transformation From Sap Ecc To Sap S/4hana Finance Erp In The Usa: Investigating Human-Centric Challenges And Strategic Benefits, Muhammad Kamran Mirza Mr.

Harrisburg University Dissertations and Theses

This study examines the human-centric challenges and organizational strategic benefits associated with migrating from SAP ECC to SAP S/4HANA Finance in U.S.-based organizations. The motivation behind this ERP transformation is that the company aims to automate its business processes and achieve operational efficiency. The success of ERP migration is shaped by user experience. Human barriers such as cognitive load, burnout and reluctance to change, insufficient user training, and work stress can threaten the success of ERP migration. This study aims to examine human-centric issues and organizational dynamics to propose effective ERP migration strategies that can help future ERP migrations and …

Student Life E-Newsletter February 17, 2026, Seattle University School Of Law Student Life

Student Life E-Newsletters

No abstract provided.

Creating A Flipped-Classroom With Universal Instructional Design In A Hybrid Stem Course To Facilitate Active Learning, Lori L. Dunlop-Pyle

Teaching Online Pedagogical Repository

The strategy describes using Universal Instructional Design (UID) principles to create a hybrid STEM course to facilitate active learning exercises in class for a diverse group of learners.

Assessing Working Musicians’ Perspectives Of Need And Barriers Regarding Lay Harm Reduction Efforts For Substance-Related Harm In South Carolina, Sarah Grace Frary

Faculty Publications

Background

Harm Reduction (HR) approaches applied to substance use aim to decrease the toxic consequences of overdose. The addition of xylazine and benzodiazepines to fentanyl, the primary opioid in the US drug supply, increases the likelihood of overdose. Likewise, adding fentanyl to other popular substances, such as cocaine and methamphetamine, has further driven the exponential increase in opioid and stimulant overdoses. Engaging lay community members in HR efforts may help to combat the overdose crisis. Substance use is common in live music settings, and working musicians may be uniquely positioned within “the scene” – individuals who populate specific cultural niches …

Understanding Software Engineering Practices And Tools In Undergraduate Mechanical Engineering Students, Prisha Bhatia, Ramzey Burdette, Titilayo Oshinowo, Michelle Jarvie-Eggart, Stephanos Matsumoto

Michigan Tech Publications

Though software development has increasingly become a part of modern engineering practice, even outside of computing, we lack a sufficiently deep understanding of how engineers in many disciplines learn and use software engineering practices and tools (SEPTs). SEPTs include, but extend beyond, programming itself, consisting of practices (e.g., unit testing) and tools (e.g., version control software) that support the design, implementation, or maintenance of software. While many disciplines outside of computing teach programming in their undergraduate curricula, little is known about how these disciplines use, teach, or adopt SEPTs. We thus conducted an exploratory qualitative study on SEPTs among undergraduate …

Spartan Daily, February 17, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 11

Neurophysiological Connectomic Signatures Of Consciousness During Propofol-Induced General Anesthesia, Qingyu Teng, Zhongcong Xie, Daniel Sessler, Zhe Zhang, Peng Xu, Ti-Fei Yuan, Tao Xu

Faculty, Staff and Student Publications

General anesthesia induces reversible changes in consciousness through cortical activity and connectivity alterations, yet the functional connectome dynamics underlying propofol-induced unconsciousness remains unclear. We analyze high-density 128-channel electroencephalogram (EEG) from 31 surgical patients using source localization to identify neurobiological connectome signatures of propofol anesthesia. Propofol anesthesia increases delta and theta functional connectivity and decreases alpha, beta, and gamma connectivity. A classification model and dynamic analysis of consciousness loss reveals that alpha-band connectivity between parietal, occipital, and subcortical regions is critical for sustaining consciousness, with its disruption marking a key transition to unconsciousness. EEG from 46 additional patients under mild sedation …

International Society Of Sports Nutrition Position Stand: Effects Of Dietary Antioxidants On Exercise And Sports Performance, Drew E. Gonzalez, Broderick L. Dickerson, Brandon M. Roberts, Jennifer A. Kurtz, Adam M. Gonzalez, Matthew J. Mcallister, Jeffrey L. Heileson, Richard J. Bloomer, Shawn M. Arent, Darren G. Candow, Jeffrey R. Stout, Karen A. Hecht, Bill Campbell, Chad M. Kerksick, Douglas Kalman, Jose Antoino, Richard B. Kreider

Faculty Publications

Following a comprehensive review, the International Society of Sports Nutrition (ISSN) has developed an official position on the role of dietary antioxidants in exercise and sport. Antioxidants play a complex, context-dependent role in vivo; they can facilitate recovery from exercise but may also hinder training adaptations when consumed at supraphysiological doses. While endogenous antioxidant systems can effectively maintain redox balance, dietary sources, particularly whole foods, can help mitigate excessive oxidative stress following intense/heavy training or inadequate recovery. The influence of dietary antioxidants depend on timing, dosage, type, and individual factors. The ISSN’s official position encompasses the following: (1) Redox balance …

Evaluating The American Society Of Hematology Quality Measure On Timeliness Of Analgesics For Sickle Cell Disease Pain Crisis, Ibrahim Gwarzo, Harish Chandra Dega, Paula Tanabe, Robin Miller, David C. Brousseau

Department of Medicine Faculty Papers

The American Society of Hematology (ASH) proposed the median time to first emergency department (ED) administration of pain medication for patients with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE) as a site-level quality measure. Generalizable studies assessing current guideline adherence recommending pain medications within 60 minutes are lacking. We leveraged multisite electronic health record data from Epic's Cosmos research platform to analyze ED encounters for SCD VOE from 1 January 2019 to 31 December 2024, with administration of at least 1 pain medication. We calculated the quality measure (median time to first pain medication) and ranked sites based on …

Vegetation Enhances Nitrogen Removal In Stormwater Ponds In Coastal South Carolina, Darcy Perin, Annie Bourbonnais

Faculty Publications

Coastal development and the increase in impervious surfaces lead to greater stormwater volumes, a key contributor to nonpoint source pollution. Stormwater ponds are generally highly efficient in eliminating particle-bound nutrients, such as phosphorus, but are often much less effective at removing dissolved nutrients, like nitrogen. Excess inorganic nitrogen can lead to coastal eutrophication, harmful cyanobacterial blooms, and coastal hypoxia. However, inorganic nitrogen can be removed from the environment through several different microbially facilitated processes. This research aims to estimate the rates of nitrogen removal (i.e., by denitrification), the net N₂ fluxes, and internal recycling (DNRA) across the sediment-water interface …

Rock Galaxy Album Release Concert And Lunar New Year Celebration

Bailey School of Music Concert Programs

featuring music composed using feng shui by Zack Browning

Managing Acute Myocardial Infarction In Remote Oman: Real-World Data From Al Wusta Governorate, Thuraiya Malik Abdullah Al Harthi, Ibrahim Al Mahrouqi, Amin Elbanna, Karema Hamed, Mohammed Abushilla, Venkatesh Kumar, Maryam Al Nabhani, Hasina Al Harthi, Abdulmunim Al Farsi, Adil Al Mahrouqi

Sultan Qaboos University Medical Journal

Objectives: Acute ST-segment elevation myocardial infarction (STEMI) is a time-sensitive cardiac emergency requiring prompt reperfusion therapy. Management and outcomes in remote areas are underexplored. This study explored the STEMI reperfusion network in Al Wusta governorate in Oman and evaluated the effectiveness of pharmacological thrombolysis in general practitioner (GP)-led, resource-limited hospitals. Methods: This retrospective study reviewed administrative health registries and medical records of patients presenting with STEMI to hospitals in the Al Wusta governorate between June 2017 and December 2024. Response to thrombolysis was defined as 50% resolution of ST-segment on electrocardiogram. Outcomes post-thrombolysis were prespecified. Multivariate logistic regression was used …

Micro-Refuges Or Ecological Traps: Context-Dependent Effects Of Rock Pools On Intertidal Biodiversity Across Latitudes, Louise B. Firth, Andrea Desiderato, Antony M. Knights, J. David Aguirre, Juan C. Astudillo, Juan C. Azofeifa-Solano, David T. Bilton, Su Yin Chee, Hartvig C. Christie, Ronaldo A. Christofoletti, Amelia Curd, Katherine A. Dafforn, Megan N. Dethier, Yun Wei Dong, Gabin Droual, Stanislas F. Dubois, Free Espinosa, Ally J. Evans, Andy Foggo, Stephen J. Hawkins, Mick E. Hanley, Ben P. Harvey, Eliza Heery, Seokwoo Hong, Amanda R. Hsiung, Tommy T.Y. Hui, Mar Humet, Katrin Iken, Soniya B. Jethva

School of Biological and Marine Sciences

AimWe investigated how local-scale environmental heterogeneity influences biodiversity patterns across broad biogeographic gradients, using intertidal microhabitats as a model system within one of the most environmentally stressful ecosystems on Earth.LocationIntertidal habitats at 26 locations (two rocky shore sites per location) across six continents, spanning 98° of latitude (38°S to 60°N).Time Period2019–2022.Major Taxa StudiedAlgae, sessile and mobile invertebrates.MethodsWe compared biodiversity and thermal environments across contrasting microhabitats (rock pools and adjacent emergent rock) along a latitudinal gradient, sampling during environmentally ‘milder’ and ‘harsher’ periods. Biodiversity was quantified using multiple richness metrics (mean, total, unique taxa) and functional diversity.ResultsMicrohabitat differences strongly influenced biodiversity …