Digital Commons Network^™

Remnant Cholesterol And Atherosclerotic Cardiovascular Disease Risk In Populations With Different Low-Density Lipoprotein Cholesterol Elevations: A Prospective Cohort Study, Hong Zheng, Guanlin Chen, Zhenyu Huo, Yulong Lan, Yuxian Wang, Peng Fu, Weiqiang Wu, Haixiang Zheng, Kuangyi Wu, Zegui Huang, Dan Wu, Shouling Wu, Youren Chen

Research outputs 2022 to 2026

Background: Low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC) are risk factors for atherosclerotic cardiovascular disease (ASCVD). However, the extent to which differences in RC levels affect ASCVD risk in populations with varying degrees of LDL-C elevation remains unclear. This study aimed to investigate whether RC can provide additional risk stratification value across different sexes, ages, and elevated LDL-C statuses. Methods: This study included 12 743 elevated LDL-C participants (LDL-C ≥3.4 mmol/L) and 50 073 age- and sex-matched non-elevated LDL-C controls from the Kailuan Study. Elevated LDL-C participants were categorized by RC levels into <0.5, 0.5 to <1.0, and ≥1.0 mmol/L subgroups. Kaplan-Meier curves and Cox proportional hazards models were used to assess the relationship between RC levels and ASCVD risk across different sexes, ages, and high LDL-C statuses. Results: During a median follow-up of 12.8 years, 1686 elevated LDL-C participants (13.2%) and 5252 non-elevated LDL-C participants (10.5%) developed ASCVD. In the borderline-high LDL-C group (3.4 ≤ LDL-C < 4.1 mmol/L), those with the lowest RC levels showed no significant risk difference compared with controls (hazard ratio [HR], 1.03 [95% CI, 0.93-1.13]), and this pattern remained consistent across different sexes and ages. In contrast, in the high LDL-C group (LDL-C ≥4.1 mmol/L), even when RC was at the lowest level, ASCVD risk remained significantly higher than that of controls (HR, 1.20 [95% CI, 1.02-1.41]). CONCLUSIONS: In the borderline-high LDL-C population, those with the lowest RC levels showed no significant risk difference compared with controls, and this pattern remained consistent across different sexes and age subgroups. In the high LDL-C population, even when RC was at the lowest level, ASCVD risk remained significantly higher than that of controls.

Empowering Neurodiverse Talent In Cybersecurity Through Fair And Inclusive Ai Education, Sheikh Rabiul Islam, Yansi Keim, Mohiuddin Ahmed, Maanak Gupta, Ingrid Russell, Mahmoud Abdelsalam

Research outputs 2022 to 2026

Cybersecurity demands creativity, persistence, and sharp pattern recognition—strengths frequently reported among neurodivergent people (e.g., autism, ADHD, dyslexia). Yet AI-driven hiring pipelines can systematically disadvantage neurodivergent applicants by misreading communication styles or valuing narrow proxies of “fit.” Demand for cybersecurity talent is growing, and experts note that neurodiverse individuals are both underrepresented and highly valuable to security teams. However, progress remains uneven without targeted educational interventions [1]. We present a curricular module that simultaneously (a) centers neurodiversity as a strength in the cybersecurity workforce and (b) trains students to audit and redesign AI hiring systems using open-source fairness and explainability toolkits …

University Placed-Based Community Engagement And Adult Learners: A Field Report In Mutual Flourishing, Elisabeth Stevens, Kate Witvliet, Abbie Lipsker, Craig Mattson

University Faculty Publications and Creative Works

Although higher education increasingly focuses on both community engagement and adult learners, community-engaged research rarely considers them together. This article bridges the gap in the literature between undergraduate adult learners and community engagement. Providing one example of a partnership that considers adult learners as necessary partners for community engagement, Calvin University’s 49507 Initiative is a place-based community educational project in southeast Grand Rapids, Michigan, focusing on the goals and needs of adult learners in the 49507 zip code and adjacent neighborhoods. Through 12 focus groups in the community, adult residents discussed their interests in higher education, identified barriers to higher …

Front Matter, Editors Of Comparative Labor Law & Policy Journal

Comparative Labor Law & Policy Journal

Volume 45, Issue 4

Non-Waivability In Labour Law: A Foundational Principle In Transition, Guy Davidov, Cynthia Estlund

Comparative Labor Law & Policy Journal

EMPLOYMENT RIGHTS SECURED IN LEGISLATION cannot be waived by employee consent. This is almost a trite proposition, a truism that labour lawyers and students usually take for granted.

Hungarian Steps Towards Freedom Of Contract, Tamás Gyulavári

Comparative Labor Law & Policy Journal

Since 1992, derogations have been allowed in individual agreements in favour of employees, with minor exceptions. The labour law reform of 2012 brought about the comprehensive reform of the hierarchy of labour law sources. As for individual agreements of the parties, the Labour Code retained the traditional rule of favourability, however, with a growing number and importance of exceptions allowing in peius derogations. Section II sets the scene by explaining the legal hierarchy of labour law sources, including derogations in collective agreements, agreements of the parties, and the meaning of the “more favourable rule.” Against this background, Section III delves …

Non-Waivability In Labour Law: An Australian Perspective, Joellen Riley Munton

Comparative Labor Law & Policy Journal

Australian industrial relations laws traditionally provided detailed mandatory standards through a system of arbitrated occupation-based awards. In the years since a shift to enterprise bargaining, the system has tolerated a greater level of flexibility, even in the way that legislated minima are framed. The options for waiving otherwise mandatory standards are, however, limited by procedural protections. The Fair Work Commission maintains a supervisory role to ensure that workers are “better off overall” as a consequence of their bargains. This article explains the many ways in which Australian labour standards permit flexible application, within constraints designed to preclude exploitative practices.

The Non-Waivability Principle: Possible Derogations From Collective Bargaining And Re-Assessment Of Individual Bargaining In Assisted Procedures, Elena Gramano, Silvio Sonnati

Comparative Labor Law & Policy Journal

This article examines the evolving landscape of Italian labour law, with a focus on the principle of non-waivability and its gradual adaptation to demands for flexibility and competitiveness. Traditionally, the Italian labour law framework has been characterised by a strong non-waivability regime, which protects employees from negotiating away their rights due to inherent power imbalances vis-à-vis employers. However, recent regulatory developments have facilitated a shift towards both collective and individual agreements that allow deviations from statutory provisions, including to the detriment of employees. The article analyses the implications of this trend, exploring key regulatory models that enhance the role of …

Derogability By Collective Agreements In Germany And The Presumption, Eva Kocher

Comparative Labor Law & Policy Journal

The promotion of derogability clauses, which allow collective agreements to deviate from statutory protection to the detriment of employees, has been an issue in the political debate on German labour law for some 20 years. While such derogability clauses can effectively allow for flexibility at the company or sectoral level, there are differing views on their suitability for promoting collective bargaining. This article highlights the paradox of such derogability clauses: They are legitimised by the presumption of fairness that underpins collective autonomy; at the same time, they create incentives for employers that challenge the very presumption of fairness. All in …

Derogability From Swedish Statutory Labour Law, Birgitta Nyström

Comparative Labor Law & Policy Journal

The possibility for the social partners to derogate from statutory legislation in the area of labour and employment law is an important characteristic of the so-called “Swedish model” for industrial relations and labour market regulation. With a system built on collective bargaining and collective agreements, and where legislation in the labour law area was rather scarce until the 1970s, freedom for the social partners is a core element. The possibility to derogate from certain parts of statutory labour law by collective agreements also gives room to adapt rules for different kinds of businesses and trades. Sweden is a member of …

The International Covenant On Economic, Social And Cultural Rights And The Employment Relation By Klaus Lörcher, Niklas Bruun, Ana Teresa Ribeiro, Hart Publishing, 2025, Manfred Weiss

Comparative Labor Law & Policy Journal

AFTER HAVING PUBLISHED THREE ENLIGHTENING BOOKS on the European Convention on Human Rights (ECHR), on the European Social Charter (ESC), and on the Charter of Fundamental Rights of the European Union (CFREU), the authors of the Transnational Trade Union Rights Expert Network of the European Trade Union Institute have now transcended the European territory and presented a publication on a global scale.

The Cost Of Admission: Consent, Non-Waivability, And The Governance Of Migrant Labour, Hanny Ben-Israel, Hila Shamir

Comparative Labor Law & Policy Journal

This article examines how the principle of non-waivability in labour law is being systematically eroded for migrant workers. It argues that a fundamental tension exists between labour law — which seeks to protect and empower workers — and migration law — which prioritises the welfare of citizens, instrumentalises migrant labour, and seeks to limit redistribution of a nation’s resources, benefits, and opportunities to non-citizens. The article demonstrates how consent-based arguments, rooted in migration law, are used to justify the exclusion of non-citizens from otherwise non-waivable labour protections. By analysing legislative, judicial, and policy decisions, it reveals how these arguments contribute …

Limit Theorems For Andrews’ Restricted Overpartitions, Tapas Bhowmik, Alex Cao, Jack Frew, John Lehman, Wei-Lun Tsai

Faculty Publications

The study of overpartitions in recent years has been used to great effect in various fields, including hypergeometric series, q-series identities, and mathematical physics. We investigate the limiting distributions of the number of parts in a family of overpartitions of n,  introduced by Andrews, where parts are counted with two different weights. Using Andrews’ identities and the saddle-point method, we establish two central limit theorems (CLTs) for the number of parts as n → ∞, corresponding to these weightings. We also derive explicit formulas for the mean and variance in each case.

Fort Zumwalt East Students March On St. Peter’S City Hall In I.C.E. Protest, Justin Powell

Lindenlink (2012- )

No abstract provided.

General Anesthesia Versus Conscious Sedation For Mechanical Thrombectomy In Patients With Acute Ischemic Stroke In The Most Trial, Umeshkumar Athiraman, Akash Roy, Andrew Barreto, Joseph Broderick, Colin Derdeyn, Jordan Elm, James C Grotta, James Ingles, Achala Vagal, Max Wintermark, Opeolu Adeoye

2020-Current year OA Pubs

BACKGROUND: Several observational studies have supported the use of conscious sedation (CS) for endovascular thrombectomy in patients with acute ischemic stroke and associated general anesthesia (GA) with poor functional outcomes. Recently, few randomized controlled trials have shown no difference in the functional outcomes between GA and CS. The aim of this paper is to compare the outcomes of GA versus CS in patients with acute ischemic stroke undergoing mechanical thrombectomy in the MOST (Multi-arm Optimization of Stroke Thrombolysis) trial.

METHODS: Patients who underwent mechanical thrombectomy for acute ischemic stroke under GA or CS in the MOST trial were included. The …

Long-Acting Interleukin-7 Improves The Efficacy Of Oncolytic Viral Therapy In Glioblastoma, Yuping Derek Li, David A Giles, Yi Huang, Ashwani Kesarwani, Tong Hu, Logan Page, Amanda De Andrade Costa, Jingqin Luo, Mai T Dang, Albert H Kim, John F Dipersio, David T Curiel, Michael S Diamond, Milan G Chheda, Et Al.

2020-Current year OA Pubs

Despite advances in immunotherapy, the prognosis for patients with glioblastoma (GBM) remains poor. The efficacy of GBM-targeted immunotherapies is limited by the paucity of functional T cells in the tumor microenvironment, a consequence of the local and systemic immunosuppression prevalent in patients with GBM. To overcome these challenges, here we develop a treatment strategy we term "expand and pull," which uses systemic administration of rhIL-7-hyFc, a long-acting recombinant human interleukin-7, to increase peripheral T cell abundance ("expand"), followed by intratumoral oncolytic virus treatment to recruit these cells to the tumor microenvironment ("pull"). We show that rhIL-7-hyFc improves the efficacy of …

Spatiotemporal Histogenesis Of The Developing Human Cerebellum Reveals Dynamic Layering Of Bergmann Glia, Sri Yellampally, Anders W Erickson, Virginia Fernandez, Ferechte Encha-Razavi, Kimberley A Phillips, Christine Haberler, Nicole Amberg, Victor Borrell, Paul A Northcott, Michael D Taylor, Kathleen J Millen, Parthiv Haldipur

Faculty, Staff and Students Publications

Bergmann glia (BG) are a specialized glial population essential for cerebellar development, yet their developmental timeline and molecular identity in the human cerebellum remain poorly understood. Here, we combined detailed histopathological analysis with spatial transcriptomics and single-nucleus RNA sequencing to generate a developmental atlas of human cerebellar BG. Histology revealed that BG emerge around 11 post-conception weeks (PCW), initially serving as a scaffold for Purkinje cells (PCs) migrating into the PC layer of the cerebellar cortex. Following the establishment of a multilayered PC arrangement, BG form a distinct parallel layer separated from the PCs by the lamina dissecans (LD), with …

Chemical And Structural Characterization Of Ramie-Based Epoxy Composites Reinforced With Macadamia Nut Shell Biochar, Dawit Tafesse Gebreyohannes

Faculty, Staff and Students Publications

This study examined the effect of biochar by macadamia nut shell waste on the mechanical behaviour of ramie fibre reinforced epoxy composite. Controlled pyrolysis was used to prepare biochar at 350 °C, followed by ball milling to produce a mesoporous carbon structure with a crystallinity index of 40.5%, a crystallite size of 1.6 nm, a Brunauer–Emmett–Teller (BET) surface area of 326 m2/g and an average pore size of 3.8 nm. Fourier Transform Infrared Spectroscopy (FTIR) and X-ray diffraction (XRD) analyses confirmed partial graphitization and the presence of oxygen-containing functional groups, while surface roughness analysis (Ra = 0.2382 µm, Rq = …

Lowering Morbidity And Readmissions Of Underserved Preterm Infants To Reduce Acute Care Hospital Spend, Adaugo Amuta

Walden Dissertations and Doctoral Studies

Neonatal readmissions remain a significant challenge in urban acute care hospitals serving indigent preterm infants. These readmissions impose substantial financial burdens, with high-cost conditions such as bronchopulmonary dysplasia, necrotizing enterocolitis, and retinopathy of prematurity driving recurring expenditures. This integrative review examined strategies that healthcare administrators can implement to reduce neonatal readmissions, improve care equity, and optimize healthcare spending in hospitals serving vulnerable populations in the Commonwealth of Virginia. A comprehensive literature search of empirical and non-empirical studies yielded 105 results for quality assessment using the Johns Hopkins appraisal tools. A total of 29 were included for thematic analysis. Five main …

Lipidomic Profiles Associated With Treatment Related Hepatotoxicity In Children With Acute Lymphoblastic Leukemia., M Monica Gramatges, Kevin J Williams, Baojiang Chen, Melissa B Harrell, Olga A Taylor, Michael E Scheurer, Philip J Lupo, Karen R Rabin, Joanna S Yi, Van Huynh, Steven D Mittelman, Etan Orgel, Austin Brown

Faculty, Staff and Students Publications

Introduction: Treatment for childhood acute lymphoblastic leukemia (ALL) can result in hepatotoxicity. Despite being a common complication of ALL therapy, mechanisms and biomarkers of treatment-associated hepatotoxicity (TAH) are not well described.

Methods: We conducted lipidomic profiling to identify plasma lipids associated with TAH in children receiving ALL therapy utilizing a nested case-control framework. TAH was defined as (1) transaminitis: ALT/AST ≥ CTCAE grade 3, and/or (2) conjugated hyperbilirubinemia: > 3.0 mg/dL during induction therapy or > 2.0 mg/dL post induction. A total of 90 patients (45 matched pairs) treated at Texas Children's Hospital between 2012 and 2021 were selected for lipidomic profiling, …

Associations Between The Microbiome And Immune Responses To An Adenovirus-Based Hiv-1 Candidate Vaccine Are Distinct Between African And Us Cohorts, Yuhao Li, Daniel J Stieh, Lindsay Droit, Andrew Hyoungjin Kim, Rachel Rodgers, Kathie A Mihindukulasuriya, Leran Wang, Maria G Pau, Olive Yuan, Herbert W Virgin, Dan H Barouch, Megan T Baldridge, Scott A Handley

2020-Current year OA Pubs

Optimization of prophylactic vaccine regimens to elicit strong, long-lasting immunity is an urgent need highlighted by the COVID-19 pandemic. Stronger vaccine immunogenicity is frequently reported in individuals living in high-income countries compared to individuals living in low- and middle-income countries. While numerous host genetic and immune factors may influence vaccine responses, geographic restrictions to vaccine effectiveness may also be influenced by the intestinal microbiota, which modulates host immune systems. However, the potential role of the gut microbiota on responses to HIV-1 vaccines has not yet been explored. We analyzed the bacteriome by targeted 16S sequencing and the virome by virus-like …

Community-Associated Quinolone-Resistant And Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Isolates Are Similar To Clinical Infection Isolates By Sequence Type And Resistome, Emily E Benedict, Wesley Agee, Tiffany Hink, Katelyn L Parrish, Kimberly A Reske, Kate Peacock, Rachel E Bosserman, Alyssa Valencia, Akshay Saluja, Elianora Ovchiyan, Olivia Arter, Kevin Jolani, Erik R Dubberke, Gautam Dantas, Jennie H Kwon

2020-Current year OA Pubs

No abstract provided.

Variable And Conserved Features Of Copy-Back Viral Genome Populations Generated De Novo During Sendai Virus Infection, Yanling Yang, Yuchen Wang, Carolina B López

2020-Current year OA Pubs

Copy-back viral genomes (cbVGs) are generated during the replication of negative-sense RNA viruses when the polymerase drops off from the genome and reattaches to the nascent strand. cbVGs have strong immunostimulatory properties and impact infection outcomes. Despite their importance, the composition and mechanisms of

Larval Zebrafish Minimize Energy Consumption During Hunting Via Adaptive Movement Selection, Thomas Darveniza, Robert Wong, Shuyu I Zhu, Zac Pujic, Biao Sun, Matthew Levendosky, Ramesh Agarwal, Michael H Mccullough, Geoffrey J Goodhill

2020-Current year OA Pubs

Animals must balance behavioral goals with the energetic costs of movement. How such trade-offs are implemented algorithmically during natural behavior, and how they adapt to changing energetic constraints, remains poorly understood. Here we show that larval zebrafish adjust their motor strategies during prey hunting to minimize energy expenditure. Using high-speed video tracking and 3D computational fluid dynamics simulations, we quantified the energy costs (in Joules) of different movement types across three developmental stages. While the structure of discrete movement types ("bouts") remained stable with age, their selection probabilities changed depending on their energetic cost, such that more expensive bouts were …

Cannabis And Psychedelics Among U.S. Young Adults: Use, Messaging Exposure, Perceptions, And Legalization Support, Carla J Berg, Cassidy R Loparco, Darcey M Mccready, Laura C Schubel, Patricia A Cavazos-Rehg, Erin Kasson, Shriya Thakkar, Diane M Ndisebuye, Y Tony Yang

2020-Current year OA Pubs

This study assessed the correlates of cannabis and psychedelic use and legalization support among young adults in the United States (US). Using 2025 data among adults ages 18-34 (

Accurate Interpretation Of Within-Host Dissemination Using Barcoded Bacteria, Rachel T Giorgio, My T Le, Ting Zhang, Caitlyn L Holmes, Karthik Hullahalli

2020-Current year OA Pubs

Bacterial dissemination across tissues is a critically important process influencing infection outcomes. Monitoring within-host dissemination is challenging because conventional measures of bulk bacterial burden cannot distinguish between lineages that are shared between tissues and those that replicate locally. This limitation can be overcome using barcoded bacteria, where deep sequencing of the barcode locus and comparisons of barcodes between tissues define which lineages spread within the host. Numerous studies have used barcoded bacteria to generate high-resolution maps of dissemination. However, since multiple cells in the infectious inoculum can contain identical barcodes, inferences about dissemination can be confounded when distinct lineages from …

To Shape A New World, Robin Friedman

Dewey Studies

No abstract provided.

Research Note: Project Initiated In China To Translate And Research The Philosophical Writings Of William James, Wang Chengbing

Dewey Studies

No abstract provided.

Contemporary Philosophical Proposals For The University, Seth Vanetta

Dewey Studies

No abstract provided.

John Dewey Studies In Central Europe: Eli Kramer Interviews Emil Visnovsky, Emil Visnovsky, Eli Kramer

Dewey Studies

No abstract provided.