Digital Commons Network^™

S6k1 Modulates Stat3 Activation To Promote Resistance To Radiotherapy In Lung Cancer, Ali Calderon-Aparicio, Noelle Francois, Tyler Grenda, Shan Xu, Olugbenga Okusanya, Jun He, Nicole L Simone

Department of Radiation Oncology Faculty Papers

Radiotherapy is a mainstay in the management of locally advanced lung cancer; however, intrinsic and acquired radioresistance contribute to poor prognosis. S6K1, a serine/threonine kinase, regulates cell growth, protein synthesis, and survival, and is increased in tumors, which is linked to enhanced survival under therapeutic stress, including radiation. The mechanisms, however, are not fully understood. This study investigates the role of S6K1 in lung cancer radioresistance and the mechanisms involved. Intrinsic radioresistance in lung cancer cells was associated with increased S6K1 activation. Pharmacologic inhibition or genetic deletion of S6K1 enhanced radiosensitivity both in vitro and in vivo, highlighting the therapeutic …

Donors Provide Difference Between Hardship And Hope, Michael Newsom

University of Mississippi News

OXFORD, Miss. – When the January ice storm swept across north Mississippi, the University of Mississippi campus fell into an uneasy quiet. Trees snapped under the weight of heavy ice. Power lines froze. Buildings went dark.

Resilience In Young People Living With Hiv In Low To Middle-Income Countries: A Critical Review, Lily R. Bastian

Creating Healthy Work Environments (CHWE)

Background: According to the Joint United Nations Programme on HIV/AIDS (UNAIDS, 2023), 39 million people globally were living with HIV, and 1.3 million people became infected in 2022. Of those, 27% were young people (ages 15-24), including 210,000 young women and 140,000 young men. HIV is an expanding epidemic despite an overall reduction in the annual incidence percentage and the significant strides that have been made towards prevention of transmission and treatment with antiretroviral therapy (ART). Low to middle-income countries (LMICs) are especially vulnerable to the HIV/AIDs epidemic. The identification and promotion of resilience factors could play a crucial role …

Executive Committee - Agenda, 02/17/2026, Academic Senate

Academic Senate Agendas

No abstract provided.

February 17, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Gebhardt Speaker Amy Tenhouse '97 Gives Students Lobbying Industry Insights, Chris Francis

Press Releases 2020-2029

No abstract provided.

Exploring Bilingual Coding For Inclusive Computer Science Learning, Ethel Tshukudu, Neel Asheshbhai Shah, Thien Khang Kieu, Leqaa Deeb, Harshitha Venkateswaran, Aarav Ghai, Yusuf Gadelrab, Purujit Hada

Faculty Research, Scholarly, and Creative Activity

As computing education expands globally, the dominance of English in programming languages can present barriers for students who are not native English speakers. This research work investigates whether language matters in programming by examining how a bilingual programming workshop influences student attitudes, perceived understanding and comfort. Sixty bilingual participants from San Jose State University, 40 with little to no prior programming experience and 20 experienced programmers completed a two-hour workshop using the multilingual Hedy platform. Pre- and post-surveys measured changes in confidence, enjoyment, motivation, identity, and usefulness, complemented by open-ended questions about participants’ experiences. All students showed improvements across most …

Exploring K–12 Teacher Motivation To Engage With Ai In Education, Ethel Tshukudu, Katharine Childs, Gaokgakala Alogeng, Emma R. Dodoo, Douglas R. Case, Tebogo Videlmah Molebatsi

Faculty Research, Scholarly, and Creative Activity

While global interest in K–12 AI and ML education grows, many African education systems lack foundational computing education beyond basic computer literacy. This creates unique challenges for AI integration in countries where computer science isn’t part of the K–12 curriculum. Teachers are central to this effort, but little is known about what motivates them to engage with these technologies or how they use them. This study examined what motivates K–12 teachers to engage with AI and ML in Botswana. Using a mixed-methods approach, we surveyed 59 teachers using an adapted version of the Motivation to Teach Computer Science (MTCS) scale …

Racial And Sex Differences In Acute Pericarditis Among Emergency Department Chest Pain Patients: A Retrospective Cohort Study, Joshua Emakhu, Wan Ting Su, Jamie Joseph, Indra Adrianto, Christiana David, Egbe Etu Etu, Imokhai Tenebe, Andrew Bossick, Joseph Miller

Faculty Research, Scholarly, and Creative Activity

Background: Acute pericarditis is a rare diagnosis among emergency department (ED) patients with chest pain, and how race and sex jointly influence risk remains poorly characterized. We evaluated race–sex heterogeneity in acute pericarditis risk using interaction-based and marginal analytic approaches. Methods: This retrospective cohort study utilized patient-level electronic health records from 10 EDs in a large integrated health system (2016–2022). Adult patients (≥ 18 years) self-identifying as non-Hispanic Black or non-Hispanic White and presenting with chest pain were included. Acute pericarditis was identified using International Classification of Diseases, Tenth Revision codes I30.x, supported by clinical documentation. Generalized linear models with …

Validating Uas-Based Ndvi Data With Satellite Landsat Imagery For Bald Eagle Habitat Prediction In The Del Rio Springs Ecosystem, Noah Morales, Ronny Schroeder, Elise Anderson

Student Works

Vegetation health is commonly assessed using the Normalized Difference Vegetation Index (NDVI), which can be derived from multispectral sensors operating at different spatial resolutions. Validating NDVI products across sensor platforms is essential to determine their reliability for environmental monitoring and habitat assessment. This research compares NDVI derived from moderate-resolution satellite imagery and high-resolution unmanned aircraft system (UAS) imagery collected over the same study area. Landsat imagery, provided through the joint USGS–NASA mission, was used to represent satellite-based vegetation patterns, while high-resolution multispectral data were acquired using a MicaSense sensor mounted on a UAS to capture fine-scale vegetation detail.

NDVI values …

Minutes, Curriculum Committee Meeting, Tuesday, February 17, 2026, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Alaska Earthquake Center Quarterly Review July-September 2025, Heather Mcfarlin, Beth Grassi, Austin Holland, Nate Murphy, Elisabeth Nadin, Carolyn Parcheta, Michael West

Alaska Earthquake Center Reports

This series of technical quarterly reports from the Alaska Earthquake Center (AEC) includes detailed summaries and updates on Alaska seismicity, the AEC seismic network and stations, fieldwork, our online presence, public outreach, and lists publications and presentations by AEC staff. Multiple AEC staff members contributed to this report.

Community Engagement And Implementation Science: A Hermeneutic Review For Implementation Scientists, Minh X Nguyen, Zhuoheng Yin, Ye Liu, Cory D Bradley, Elvin Geng, Mayuko Itofukunaga, Nyanyiwe M Mbeye, Rayner K J Tan, Sherika Hanley, Radhika Sundararajan, Joseph D Tucker

2020-Current year OA Pubs

BACKGROUND: Community engagement is increasingly part of implementation research. However, some implementation scientists are less familiar with how to use community engagement approaches in implementation research. This hermeneutic review explores the gaps in community engagement within implementation research and examines community engagement approaches for implementation researchers.

METHODS: We conducted a hermeneutic review to synthesize information in the literature on community engagement in implementation research. We searched PubMed related to community engagement and implementation research. Articles were eligible for inclusion if they were published in English, had full-text available and were likely to add meaning and valuable insights to address our …

The Recent Rash Of Biotechnology Risks: A Call To Fortify Force Capability, James Giordano

Strategic Insights

This commentary looks at recent incidents that highlight emerging national security risks posed by advances in biotechnology and synthetic biology. The discovery of suspicious biological materials stored in a residential facility in Reedley, California, and reports that a rare neurotoxin may have been used against Russian opposition leader Alexei Navalny illustrate how barriers to acquiring and operationalizing biological and chemical agents are declining. Tools such as gene editing, modular DNA assembly, laboratory automation, and AI-enabled biological design are expanding the range of actors capable of producing or modifying bioagents while complicating detection and attribution. Strengthened biodefense measures, including “biosecurity-by-design,” improved …

2026 Psalms Of Lament: Lenten Devotionals, Benjamin Wagner, Stephenie Hovland, Jonathan Landrey, Christopher Genszler, Matthew Byrd, Jonathan Poppe, Amy Genszler, Joshua Camp, Lydia Grabau, Ezekiel Grabau, Henry Eising, Jonathan Lehms, Mark Squire, Wesley Clark, Stephen Christian, Kyle Bliss, Brian Schneck, Jack Engelder, Nicholas Vukalovich, Cole Carlson, Aaron Halboth, Rick Crain, Ezekiel Potts, Zachary Benkert, Natnael Kebede, Jacob Stefanec, Joshua Fields, Peter Ventimiglia, Andrew Borseth, Jesse O’Shell, Isaiah Mudge, Erik Osmundson, Stephen Moore, Nathaniel Hall, Matthew Younghouse, Corrie Steel, Nathaniel Pekari, David Gray, Jarod Vorseth, Ryan Skove, Samuel Held, Joseph Musolino, Chris Atlee, David Krueger

Other Student Publications

The Psalms of Lament comprise nearly a third of the Psalter, making them one of the most prominent prayer forms in Scripture. These psalms give voice to human suffering, doubt, and struggle before God—not as expressions of weak faith, but as honest cries from those who trust God enough to bring their deepest pain into His presence. A lament typically moves through several stages: addressing God, describing the complaint or distress, asking "how long?" or "why?", petitioning God for help, expressing trust despite circumstances, and often concluding with praise or a vow to praise. Through lament, the psalmists model a …

How Do Repeated Financial Incentives Affect Hiv Care-Seeking Behaviours Over Time? Evidence From A Cluster-Randomised Controlled Trial, Solis Winters, Emmanuel Katabaro, Babuu Joseph, Janeth Msasa, Hamza Maila, Kassim Hassan, Amon Sabasaba, William H. Dow, Prosper F. Njau, Sandra I. Mccoy

Health Studies Faculty Publications

Background A more nuanced understanding of behavioural responses to incentives over time, particularly after they are removed, could guide more effective interventions. In this study, we build on the primary trial evaluation to explore the dynamic effectiveness of small, short-term monthly financial incentives on HIV care-seeking behaviours during and after incentive removal.

Methods We conducted a 32-site cluster-randomised controlled trial (NCT04201353) among adult antiretroviral therapy (ART) initiates (< 30 days) in four regions of Lake Zone, Tanzania. HIV care and treatment clinics were randomly assigned 1:1 to the intervention (up to 6 monthly cash transfers of 22 500 TZS each (~US$10), conditional on appointment attendance) or standard of care. Using time-to-event analysis, we assess the effect of incentives on three HIV-care seeking behaviours: missed appointment by >4 days, < 90% ART adherence and interruption in treatment of >28 days.

Results Among 1990 participants, we found large significant reductions in rate of missed appointments (hazard ratio (HR), 95% CI: 0.51, 0.39 to 0.68), < 90% ART adherence (HR, 95% CI: 0.58, 0.41 to 0.83) and interruption in treatment (>28 days without …

Outsourcing Legal Modernity: Late Colonial Constitutionalism In Muslim Northern Nigeria, Rabiat Akande

Articles & Book Chapters

The final years of British imperial rule in Northern Nigeria witnessed efforts to source appropriate models of legal modernization from the Muslim world. The models afloat in constitutional discourse, those of Libya, Sudan, Pakistan, and Egypt, were held up by respective proponents as ideal for resolving the long-fraught question of the relationship between Islam and public law in a modern state. Yet, the evocations of these foreign models were idealized imaginaries; by framing these models as settled facts, the Northern Nigerian evocations flattened the constitutional experience of these states and obscured unfolding struggles over the nature of legal modernity. Against …

Faculty Senate Executive Committee Minutes February 17, 2026, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Call to Order
• Provost Search
• University Business
• Faculty Senate Business
• Reports
• Faculty Development and Educational Leadership
• Parking and Transportation
• Information
• Old Business
• New Business
• Adjourn: 4:50 PM

Faculty Senate Executive Committee Agenda February 17, 2026, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order
• Approval of Minutes January 20, 2026
• 3:05 Provost Search
• 3:20 University Business
• 3:35 Faculty Senate Business
• 3:50 Report
• Faculty Development and Educational Leadership
• Parking and Transportation
• 4:00 Information
• EPC Report - February 5, 2026
• 4:10 Old Business
• 4:15 New Business
• Special Faculty Forum
• Adjourn: 4:30 pm

Molecular Profiling And Tumor Biomarker Analysis Of Gog281/Logs: A Positive Late-Phase Trial Of Trametinib For Recurrent/Persistent Low-Grade Serous Ovarian Carcinoma, Robert L. Hollis, Austin Miller, Heather A. Lankes, Kwong-Kwok Wong, William Rodgers, David Millan, Karen Carty, Robert L. Coleman, Kathleen N. Moore, Angeles Alvarez Secord, David M. O'Malley, John K. Chan, Andrea R. Hagemann, Stephanie Gaillard, Saketh R. Guntupalli, Mitchell I. Edelson, Peter G. Rose, Oliver Dorigo, Susana Banerjee, Ailith Ewing, Michael Churchman, Anil K. Sood, C. Simon Herrington, Charlie Gourley, David M. Gershenson

Abington Jefferson Health Papers

PURPOSE: Low-grade serous ovarian carcinoma (LGSOC) is a distinct form of ovarian cancer characterized by younger patient age and relative chemoresistance. The GOG281/LOGS trial (NCT02101788) investigated the efficacy of the MEK inhibitor trametinib compared with physician's choice standard-of-care (SOC) in patients with LGSOC with persistent/recurrent disease. The study demonstrated significantly improved progression-free survival (PFS) in the trametinib-treated arm.

EXPERIMENTAL DESIGN: Two hundred and sixty patients with recurrent/persistent LGSOC were enrolled and randomly assigned in GOG281. We performed molecular analysis of 170 patients with available tumor specimens, comprising whole-exome sequencing and phospho-ERK (pERK) IHC, to identify biomarkers of clinical benefit from …

Evaluating The Implementation Of Oregon's Dsm-5-Informed Autism Eligibility Revisions: Interest-Holder Perspectives And Policy Implications, Bradley Josef Hendershott

Dissertations and Theses

Under the Individuals with Disabilities Education Act (IDEA), states establish their own autism spectrum disorder (ASD) eligibility criteria, resulting in substantial interstate variation and frequent misalignment with medical diagnostic standards. In 2019, Oregon revised its ASD eligibility criteria by directly incorporating DSM-5 diagnostic criteria, reflecting proponents' theory of action that this alignment would improve conceptual clarity, identification accuracy, and coherence across educational and medical systems. While an early implementation study documented generally positive early effects reported by evaluators, no research has systematically examined whether the DSM-5 alignment achieved its anticipated effects, how the revised criteria function after multiple years of …

Minutes, Faculty Affairs Committee Meeting, Tuesday, February 17, 2026, Faculty Affairs Committee

Faculty Affairs Committee Minutes

No abstract provided.

Winter Olympic Wildcats: Current Student, Recent Graduate Compete In Italy, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Und Leads Implementation Team Meeting Agenda — February 17, 2026, University Of North Dakota

LEADS Implementation Documents

Agenda for the February 17, 2026 meeting of the UND LEADS Implementation Team. The agenda includes subgroup reports, event announcement distribution, and continued discussion of Affinity recommendation development.

‘Focus’ On Ecommons, Ryan O'Grady

University Libraries Blog Archive

A campus newspaper published for faculty and staff from 1967 to 1982 is now available digitally worldwide.

Executive Committee - Minutes, 02/17/2026, Academic Senate

Academic Senate Minutes

No abstract provided.

Effects Of Varying Ph, Temperature, And Sucrose Concentration On The Activity Of Invertase Enzyme, B. Rainwater, S. Pratihar

Journal of the Arkansas Academy of Science

The purpose of this research is to study the factors that affect the enzymatic activity of invertase, extracted from baker’s yeast, on hydrolysis of sucrose in aqueous medium. Invertase, a glycoprotein, is an enzyme in the glycoside hydrolase family. It catalyzes the hydrolysis of sucrose producing equimolar mixture of a-D-glucose and b-D-fructose. Invertase shows high affinity for the substrate, and is capable of both cleaving the glycosidic linkage in sucrose and transferring ab-D-O-fructofuranoside residue to an acceptor substrate. (Toledo et al. 2019). A detailed mechanism of the action of invertase was postulated by Shall et al. (Shall et al. 1971). …

Autoimmune Encephalitis: The Psychological Impact Of Brain Inflammation, Ophelia Hyde

Creating Healthy Work Environments (CHWE)

Autoimmune Encephalitis (AE) is a disease in which the cells of the immune system attack the brain, causing inflammation also known as encephalitis. Brain Inflammation diminishes its proper functioning and can severely impact basic processing skills. The presentation of AE is difficult to identify, because it varies depending on the antibodies involved and the location of inflammation. Autoimmune encephalitis can gradually worsen over time, and can even be fatal. The disease is rare, but as diagnosis methods improve, more and more cases are being discovered. Autoimmune Encephalitis has been found to be more common in women than men. There …

Biomarkers In Alzheimer's Disease Clinical Trials: 2025, Amanda M. Leisgang Osse, Yadi Zhou, Jefferson W. Kinney, Andrew Hooyman, Ayan Sengupta, Jorge Fonseca, Aaron H. Burstein, Laura Nisenbaum, Howard M. Fillit, Feixiong Cheng, Jeffrey L. Cummings

Physical Therapy Faculty Articles and Research

Biomarkers play an important role in Alzheimer's disease (AD) clinical trials in several contexts of use, including defining trial eligibility and serving as outcome measures. Utilizing clinicaltrials.gov, a registry of clinical trials, we assessed biomarker usage across all active AD disease-targeted therapeutic (DTT) trials. Biomarkers are widely used in AD DTT trials, with 84% including a fluid, imaging, and/or digital biomarker, either as an inclusion criterion or as an outcome measure. In DTT trials, biomarkers were included in 83% of Phase 3 trials, 91% of Phase 2 trials, and 72% of Phase 1 trials. Biomarkers were used for trial inclusion …

Faculty Senate Executive Committee Agenda (2/17/2026), Csusb Faculty Senate

CSUSB Faculty Senate records

No abstract provided.