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Coping Strategies, Barriers, And Supports Of Female Nurses And Veterans With A Work-Related Traumatic Exacerbation Of An Existing Respiratory Disorder, Joanna Lynn Phillips Mar 2026

Coping Strategies, Barriers, And Supports Of Female Nurses And Veterans With A Work-Related Traumatic Exacerbation Of An Existing Respiratory Disorder, Joanna Lynn Phillips

Walden Dissertations and Doctoral Studies

The United States Department of Defense and Bureau of Labor Statistics estimated that female veterans and nurses experience work-related trauma at rates of 51% or higher. While many studies have examined their mental health outcomes, posttraumatic worsening of physical health has been less studied in this population. This generic qualitative inquiry was conducted to gain a deeper understanding of the subjective lived experiences of female nurses and veterans' work-related traumatic exacerbation of an existing respiratory disorder. The coping strategies developed, the potential barriers they overcame, and the support systems used were examined. The theoretical framework that grounded this study was …

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Exercise Effects On Decreased Levels Of Depression In Female Breast Cancer Patients, Dorothy Y. Spencer Mar 2026

Exercise Effects On Decreased Levels Of Depression In Female Breast Cancer Patients, Dorothy Y. Spencer

Walden Dissertations and Doctoral Studies

Breast cancer patients with major depressive disorder (MDD) are at a high risk of experiencing pain and fatigue, anxiety and substance use, poor quality of life, marital spouses with elevated depression, impaired sexual functioning, sleep disorders, poor immune system functioning, rapid progression of cancer, and higher mortality rates. Grounded in Fritz Heider’s attribution theory, the purpose of this quantitative quasi-experimental study was to examine the relationship between physical exercise and a decrease in MDD. The participants comprised of 15 female breast cancer patients, 18 years of age and older, who may have experienced depression. The participants completed the Beck Depression …

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Effective Strategies For Hospital Adoption Of Value-Based Reimbursement Models, Nicholas Isbell Mar 2026

Effective Strategies For Hospital Adoption Of Value-Based Reimbursement Models, Nicholas Isbell

Walden Dissertations and Doctoral Studies

Acute care hospitals continue to experience financial strain as the healthcare system transitions from fee for service to value-based reimbursement (VBR) models. The purpose of this integrative review was to identify evidence-based financial, clinical, and operational strategies that support hospital adaptation to value-based models while maintaining financial stability and high-quality care. The guiding question focused on determining which strategies reduce financial pressures and improve value-based performance in acute care hospitals. Guided by resource-based theory, this integrative review included 25 empirical and nonempirical studies published between 2019 and 2025 that examined U.S. acute care hospitals. Data were synthesized through a thematic …

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Effect Of Physical Custody On Relationship Satisfaction In Adults, Mathew Aaron Richards Mar 2026

Effect Of Physical Custody On Relationship Satisfaction In Adults, Mathew Aaron Richards

Walden Dissertations and Doctoral Studies

Custody decisions are often informed by attachment-based arguments, yet little research has examined long-term effects of custody type on adult outcomes. This study involved examining whether joint versus sole physical custody predicted relationship satisfaction, testing both parental attachment and socioeconomic status as mediators. Data were collected from 226 adult participants (mean age = 33.42), whose parents separated before age 13. Validated measures were used to assesse relationship satisfaction, parental attachment, and socioeconomic status. Participants who grew up in joint physical custody arrangements reported significantly higher relationship satisfaction compared to those who experienced sole physical custody (b = 0.54, p = …

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Perspectives Of Elementary Teachers On The Challenges Of Implementing Reading Technology, Hajirah Abdullah Mar 2026

Perspectives Of Elementary Teachers On The Challenges Of Implementing Reading Technology, Hajirah Abdullah

Walden Dissertations and Doctoral Studies

Reading skills in elementary school students continue to decline despite the efforts of teachers and lawmakers. The problem addressed through this study was that although teachers at ABC Elementary School (pseudonym) had access to 30 different software/apps for technology literacy programs that could help improve student achievement on state assessments, district data showed that very few teachers were using the technology with students. The purpose of this qualitative project study was to explore the perspectives of elementary teachers on the challenges of implementing reading technology and ways to better support its use in classroom instruction at ABC Elementary School. The …

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Hr Strategies Used To Reduce Employee Turnover And Employee Replacement Costs, Karlita Mcclinton Mar 2026

Hr Strategies Used To Reduce Employee Turnover And Employee Replacement Costs, Karlita Mcclinton

Walden Dissertations and Doctoral Studies

Ineffective employee well-being strategies can contribute to elevated levels of voluntary turnover, resulting in increased employee replacement costs, lost organizational knowledge, and operational disruption. Human resource (HR) leaders who do not successfully develop employee well-being strategies may find their organization facing operational disruptions as a result. Grounded in social sustainability and the European corporate sustainability frameworks, the purpose of this qualitative pragmatic inquiry research project was to identify and explore effective employee well-being strategies used by HR leaders to reduce employee turnover and employee replacement costs. The participants were 10 HR leaders who had implemented effective employee well-being strategies. Data …

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Exploring The Strategies Used By Caribbean Business Leaders To Adopt Artificial Intelligence To Improve Business Performance And Decision-Making, Hazarie Ramoutar Mar 2026

Exploring The Strategies Used By Caribbean Business Leaders To Adopt Artificial Intelligence To Improve Business Performance And Decision-Making, Hazarie Ramoutar

Walden Dissertations and Doctoral Studies

A lack of effective strategies for adopting generative artificial intelligence (GenAI) limits business leaders in the Caribbean’s ability to enhance business performance and decision-making. Business executives, shareholders, employees, and policymakers are vested in the success of Caribbean businesses to remain competitive and become more efficient. Grounded in the technology acceptance model (TAM), the purpose of this qualitative, pragmatic inquiry project was to identify and explore the strategies Caribbean business leaders use to successfully adopt GenAI, thereby enhancing business performance and decision-making. The participants were seven business leaders from for-profit organizations in the English-speaking Caribbean. Data were collected using semistructured interview-based …

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The Experiences Of Faith-Based Non-Profit Human Services Professionals In The Implementation Of Parental Resources For Homeless Mothers, Latasha Sublett Mar 2026

The Experiences Of Faith-Based Non-Profit Human Services Professionals In The Implementation Of Parental Resources For Homeless Mothers, Latasha Sublett

Walden Dissertations and Doctoral Studies

Homelessness is a worldwide, complex social problem that has impacted groups like women and children. In recent studies, researchers have demonstrated that homeless mothers can face mental health challenges and stressors related to parenting, while homeless children can experience emotional and physical difficulties. Parental resources have been cited as a tool to help homeless families address stress and development in distinct settings in current research; however, there was limited research on how faith-based non-profits utilize parental resources to help homeless mothers. The purpose of the generic qualitative study was to learn the perceptions and experiences of faith-based non-profit human services …

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Lived Experiences Of Black, Indigenous, And People Of Color (Bipoc) Counselors Collaborating With Multidisciplinary Teams To Treat Bipoc Clients Diagnosed With Eating Disorders, Melissa Sherfield Mar 2026

Lived Experiences Of Black, Indigenous, And People Of Color (Bipoc) Counselors Collaborating With Multidisciplinary Teams To Treat Bipoc Clients Diagnosed With Eating Disorders, Melissa Sherfield

Walden Dissertations and Doctoral Studies

Eating disorder (ED) treatment has historically been grounded in Eurocentric models that inadequately account for the cultural contexts and lived experiences of Black, Indigenous, and people of color (BIPOC), contributing to persistent disparities in care. The purpose of this descriptive transcendental phenomenological study was to explore the lived experiences of BIPOC counselors who provide culturally responsive care to BIPOC clients diagnosed with EDs. Guided by Husserl’s phenomenological philosophy of intentionality and Giorgi’s descriptive phenomenological method, the central research question addressed the lived experiences of BIPOC counselors providing culturally responsive ED care, with a sub-question addressing how counselors describe their preparedness …

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U.S. Pharmacists’ Perceptions Of Getting The Covid-19 Vaccine And How That Affects Their Interactions With The Public, Megan Boals Mar 2026

U.S. Pharmacists’ Perceptions Of Getting The Covid-19 Vaccine And How That Affects Their Interactions With The Public, Megan Boals

Walden Dissertations and Doctoral Studies

Pharmacists play a pivotal role in public health, particularly in promoting vaccination. However, vaccine hesitancy among pharmacists significantly undermines their willingness to provide effective patient counseling and to advocate for vaccination, potentially eroding public trust in vaccines. This descriptive-phenomenological study sought to understand the factors contributing to pharmacists’ COVID-19 vaccine hesitancy and how this hesitancy affected their willingness to recommend vaccines to patients. Twenty practicing pharmacists were interviewed via Zoom between September 23 and October 14, 2025. The health belief model helped interpret the study findings. Thematic analysis, as described by Braun and Clarke, was conducted to identify and interpret …

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Exploring The Lived Experiences Of African American Women In Counseling For Body Dysmorphia, Sitonja Valenzuela Mar 2026

Exploring The Lived Experiences Of African American Women In Counseling For Body Dysmorphia, Sitonja Valenzuela

Walden Dissertations and Doctoral Studies

African American women may experience body dysmorphia differently due to cultural, racial, and societal influences that shape their body perceptions and counseling experiences. Guided by a Heideggerian theoretical foundation, this hermeneutic phenomenological study aimed to explore how African American women experience receiving counseling for body dysmorphia in the United States. The guiding research question was: How do African American women with body dysmorphia experience receiving help in counseling? Eight African American women participated in in-depth, semi-structured interviews, and data analytic procedures were analyzed using the hermeneutic circle. Key findings revealed body dysmorphia as a persistent, embodied experience shaped by racialized …

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Exploring The Process Of Using Equine-Assisted Psychotherapy To Treat Anxiety, Danica Yates Mar 2026

Exploring The Process Of Using Equine-Assisted Psychotherapy To Treat Anxiety, Danica Yates

Walden Dissertations and Doctoral Studies

Anxiety is the most rapidly growing mental health problem globally, particularly among adolescents and young adults. Mental health clinicians need effective integrative health treatment strategies to address the anxiety epidemic. The purpose of this qualitative generic study was to explore the perspectives of clinicians on the process of using equine-assisted psychotherapy (EAP) to treat adolescents and young adults with anxiety through the lens of a somatic theory, bioenergetics. Data were collected using semi-structured interviews with 12 EAP clinicians and analyzed using Braun and Clarke’s thematic analysis. Three themes were identified: 1. The process of EAP is highly effective because energetic …

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Teachers And Administrators’ Perspectives Of Teacher Retention Rates During The First 5 Years Of Employment, Seth Hay Mar 2026

Teachers And Administrators’ Perspectives Of Teacher Retention Rates During The First 5 Years Of Employment, Seth Hay

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study was the high percentage of novice teachers leaving the profession during the first 5 years of teaching in a Southwestern state. Grounded in Mitchell et al.'s job embeddedness theory, the purpose of this qualitative study was to explore K-12 teachers’ perspectives on factors influencing their decision to remain in the education profession, as well as K-12 administrators’ perspectives on influencing novice teachers’ decisions to persist in the education profession in a Southwestern state. For this basic qualitative design, data were collected from 10 teachers and three administrators and analyzed using Braun and …

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The Role Of Language On Percieved Emotional Safety And Willingness To Disclose, Alexis Michele Craig Mar 2026

The Role Of Language On Percieved Emotional Safety And Willingness To Disclose, Alexis Michele Craig

Honors Capstone Projects and Theses

No abstract provided.

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Family-Level Mediators In The Intergenerational Transmission Of Maternal Childhood Trauma: Systematic Review And Meta-Analysis Of Pooled Effect Measures, Emma J. Mew, Rhayna Poulin, Veronika Shabanova, Hannah Gorman, Marie-Claire Meadows, Jessica L. Bonumwezi, Victoria Chung, Rachel Hennein, Audrey Y. Huang, Kevin Quach, Vanessa Blas, Ashlin Ondrusek, Karly Sara Weinreb, Kate Nyhan, Si’Itia Soliai-Lemusu, Jueta Mccutchan-Tofaeono, Nicola L. Hawley, Sarah R. Lowe Mar 2026

Family-Level Mediators In The Intergenerational Transmission Of Maternal Childhood Trauma: Systematic Review And Meta-Analysis Of Pooled Effect Measures, Emma J. Mew, Rhayna Poulin, Veronika Shabanova, Hannah Gorman, Marie-Claire Meadows, Jessica L. Bonumwezi, Victoria Chung, Rachel Hennein, Audrey Y. Huang, Kevin Quach, Vanessa Blas, Ashlin Ondrusek, Karly Sara Weinreb, Kate Nyhan, Si’Itia Soliai-Lemusu, Jueta Mccutchan-Tofaeono, Nicola L. Hawley, Sarah R. Lowe

Department of Psychology Faculty Scholarship and Creative Works

Children of mothers with childhood trauma are at an increased risk for mental health problems, yet the most influential family-related mediators of this intergenerational transmission remain unclear. This systematic review and meta-analysis synthesized effect sizes from 29 studies (n = 352,279 dyads) examining psychosocial family-level mediators between maternal childhood trauma and child mental health. We identified 380 simple and 40 serial mediation paths across four domains: child characteristics, maternal characteristics, parent–child relationship factors, and household characteristics. Maternal characteristics showed the largest pooled effects (proportion median [PM]: 31.2%; ratio median [RM]: 0.21), particularly maternal mental health (PM: 36.0%), maternal attachment style …

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The Relationship Of Concussion And Alcohol Use: An Investigation Into Intervening Cognitive Mechanisms, Alexi Cranford Mar 2026

The Relationship Of Concussion And Alcohol Use: An Investigation Into Intervening Cognitive Mechanisms, Alexi Cranford

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Traumatic brain injury (TBI) and alcohol use are common and pervasive issues in society today. Alcohol use is frequently linked with brain injury even in its mildest form, concussion, also known as mild traumatic brain injury (mTBI). The brain’s reward system has been shown to be involved in alcohol and substance use behaviors, and a neural basis has been demonstrated to underlie reactivity to alcohol cues. Learning theories such as classical and operant conditioning can also help conceptualize how these relationships develop. Reward sensitivity and executive functioning (particularly decision-making skills) are cognitive processes that may moderate the relationship between brain …

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Mental Health Focont Primary Care: A Continuing Education Initiative, Collin P. Mcdowell, Maddie Lozinski, Tristan Senenfelder Mar 2026

Mental Health Focont Primary Care: A Continuing Education Initiative, Collin P. Mcdowell, Maddie Lozinski, Tristan Senenfelder

DNP and Student Works

Many primary care Advanced Practice Providers (APPs) lack access to continuing education (CE) tailored to managing mental health disorders. This quality improvement project evaluated changes in APP confidence before and after participating in an online, asynchronous CE program focused on behavioral health in primary care. The project was conducted through a higher education institution in northeastern Minnesota and included 21 APPs practicing in Minnesota (N = 21); however, only two participants completed at least two of the three courses during the implementation window. Paired t-tests and the Pearson correlation coefficient were used to evaluate changes in confidence using a validated …

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Bedrock Equities Llc V. Husain Mar 2026

Bedrock Equities Llc V. Husain

All Decisions

Court denied tenant's motion to dismiss GCEL holdover premised on nonpayment of rent under RPL § 216(1)(a)(i), holding that a predicate 90-day notice of termination need not include specific factual allegations regarding the amounts of rent arrears or the months unpaid. Court noted that the landlord still bears the burden of proof at trial including demonstrating good cause to evict, the tenant retains numerous defenses, and a post-trial cure is available under RPAPL § 751(1) as incorporated by RPL § 216(3).

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Field V. Pinto Mar 2026

Field V. Pinto

All Decisions

In this licensee holdover under RPAPL § 713, court denies respondents' motion to dismiss and grants petitioner's cross-motion for summary judgment. Respondents found to be licensees, not tenants, because they lacked exclusive control and possession of a defined space — they slept in a curtained-off portion of the living room/kitchen. Rent payments alone did not create a tenancy where none was contemplated.

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Electronic Trap-State Modulation In Sm-Doped Sno Nanofibers Enables Ultrasensitive Hydrogen Sensing, Asky Fungura, Shan Hu, Shuang Gu, Yixin Liu Mar 2026

Electronic Trap-State Modulation In Sm-Doped Sno Nanofibers Enables Ultrasensitive Hydrogen Sensing, Asky Fungura, Shan Hu, Shuang Gu, Yixin Liu

Michigan Tech Publications

The demand for sub-ppm hydrogen (H) sensing is growing across emerging applications such as environmental monitoring, breath-based disease diagnostics, and early-stage battery failure detection. However, achieving reliable ppb-level detection with chemiresistive metal oxide sensors remains challenging. At trace gas concentrations, resistance modulation is often insufficient, particularly in the absence of noble metal catalysts. Here, we report samarium-doped tin dioxide (Sm-SnO) nanofibers in which electronic trap-state modulation is exploited to enable ultrasensitive hydrogen sensing. The 2 at% Sm-doped SnO nanofibers exhibited markedly enhanced H sensitivity, achieving clear detection down to 25 ppb H at 200 °C, with a theoretical limit of …

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The Relationship Between Smartphone Screen Time Duration And Individual Chronotype: A Systematic Literature Review, Diego Sergio Giasia Lumbantobing, Thalia Altamilano Pramudya Mar 2026

The Relationship Between Smartphone Screen Time Duration And Individual Chronotype: A Systematic Literature Review, Diego Sergio Giasia Lumbantobing, Thalia Altamilano Pramudya

Jurnal Epidemiologi Kesehatan Indonesia

The rapid increase in smartphone use over the past decade led to prolonged screen time across age groups, particularly during nighttime hours. Exposure to artificial light and pre-sleep digital activities was associated with circadian rhythm disruption and alterations in individual chronotype. This systematic literature review aimed to synthesize empirical evidence on the relationship between smartphone screen time duration and individual chronotype across all age groups and to identify key moderating factors influencing this association. The review was conducted in accordance with PRISMA 2020 guidelines. Literature searches were performed in PubMed, Scopus, and ScienceDirect for studies published between 2015 and 2025. …

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Prevalence And Determinant Factors Of Depression Among Pregnant Women In Poned Health Center In Tangerang City Area, Dian Geumala Hayati, Sudijanto Kamso, Popy Yuniar, Yuli Puspita Devi Mar 2026

Prevalence And Determinant Factors Of Depression Among Pregnant Women In Poned Health Center In Tangerang City Area, Dian Geumala Hayati, Sudijanto Kamso, Popy Yuniar, Yuli Puspita Devi

Jurnal Epidemiologi Kesehatan Indonesia

According to World Health Organization (WHO), approximately 10% of pregnant women experience mental disorders, with depression being particularly prevalent. In developing countries, this rate is was even higher, reaching 19.8% after childbirth and 15.6% during pregnancy. Various studies conducted in Indonesia show that the prevalence of depression among pregnant women ranges widely, from 21.4% to 26.2%.This study aimed to determine the prevalence and risk factors associated with depression during pregnancy in pregnant women at the PONED Community Health Center in Tangerang City Area. A facility-based cross-sectional study was conducted with 105 pregnant women attending antenatal check-ups at the 17 PONED …

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Ai Adoption In Research Administration At Emerging Research Institutions, Dylan Ruediger, Ruby Macdougall, Stefanie Brachfield, Douglas R. Dechow, Jonathan Parker, Jana Remy Mar 2026

Ai Adoption In Research Administration At Emerging Research Institutions, Dylan Ruediger, Ruby Macdougall, Stefanie Brachfield, Douglas R. Dechow, Jonathan Parker, Jana Remy

Library Articles and Research

"With funding from the National Science Foundation’s GRANTED program (grant #2437518), Ithaka S+R, Chapman University, and Montclair State University organized two workshops to help research administrators consider how to leverage AI to build research capacity at ERIs. Our first workshop, held at Montclair State in September 2025, brought together 31 participants from 13 academic and medical institutions in the New York/New Jersey/Pennsylvania region. Our second workshop, hosted by Chapman University on December 5, 2025, included 32 participants from 13 colleges and universities in Southern California. The approximately 2,600 ERIs in the United States receive a disproportionately small amount of federal …

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Dietary Selenium Supplementation Modulates Proliferative Gene Regulators Through Attenuating Cell Cycle Inhibition On Late G1/S Transition In Pre-Pubertal Goat Testis, Muhammad Awais Soomro, Moolchand Malhi, Tarique Ahmed Khokhar, Faiz Muhammad Khand, Zafar Ali Khoso, Maria Sardar, Muhammad Mohsen Rahimoon, Awais Bin Shahid, Muhammad Anees Memon, Nabi Bux Solangi, Jawed Ali Dhiloo Mar 2026

Dietary Selenium Supplementation Modulates Proliferative Gene Regulators Through Attenuating Cell Cycle Inhibition On Late G1/S Transition In Pre-Pubertal Goat Testis, Muhammad Awais Soomro, Moolchand Malhi, Tarique Ahmed Khokhar, Faiz Muhammad Khand, Zafar Ali Khoso, Maria Sardar, Muhammad Mohsen Rahimoon, Awais Bin Shahid, Muhammad Anees Memon, Nabi Bux Solangi, Jawed Ali Dhiloo

Journal of Bioresource Management

Selenium (Se) is essential for normal gonadal improvement in prepubertal male goat. Thus hypothesized that dietary Se may influence late G1/S through M-phase gene networks in the testis, thereby advancing pre-pubertal testicular development via attenuation of inhibitory signals and modulation of late G1 cell-cycle regulators. The total of twenty animals, male goats (3 months old) weighing ~11 kg were arbitrarily given to a basal diet (Control; C, n = 10) or the same diet plus Se-yeast (SY; 0.3 mg/kg; n = 10) for 10 weeks. Basal Se concentration in control diet was 0.037 mg/kg (ICP‑OES Optima 2100‑DV, PerkinElmer). Transcript analysis …

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Enterotoxaemia In Goats: Prevalence, Etiology, Risk Factors, And Therapeutic Approaches: A Comprehensive Review, Muhammad Mohsen, Jam Kashif Zaman, Amjad Hussain Mirani, Nazeer Hussain Kalhoro, Benazir Sahito Mar 2026

Enterotoxaemia In Goats: Prevalence, Etiology, Risk Factors, And Therapeutic Approaches: A Comprehensive Review, Muhammad Mohsen, Jam Kashif Zaman, Amjad Hussain Mirani, Nazeer Hussain Kalhoro, Benazir Sahito

Journal of Bioresource Management

Enterotoxaemia remains one of the most severe and rapidly fatal diseases affecting goats, mainly caused by Clostridium perfringens types C and D. Despite widespread vaccination practices, the disease continues to produce significant health and economic losses, particularly in intensive and semi-intensive goat production systems. This review summarizes the current understanding of enterotoxaemia, focusing on its etiology, pathogenesis, epidemiology, risk factors, diagnostic approaches, and updated therapeutic and preventive strategies. C. perfringens overgrows in the intestinal lumen under favorable conditions such as sudden dietary changes, high-energy feeding, or stress-related microbial imbalance. The toxins produced especially epsilon and beta induce intestinal necrosis, vascular …

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"I Know Who I Am": Gender-Creative Children Draw-And-Tell Their Social And Healthcare Experiences, Eline L. Lenne, Ben Anderson-Nathe, Christina J. Sun, Martha Driessnack Mar 2026

"I Know Who I Am": Gender-Creative Children Draw-And-Tell Their Social And Healthcare Experiences, Eline L. Lenne, Ben Anderson-Nathe, Christina J. Sun, Martha Driessnack

School of Social Work Faculty Publications and Presentations

Gender-creative children have an elevated risk of healthcare avoidance and adverse health outcomes related to stigma and discrimination. Despite evidence that family affirmation is protective and pediatric providers influence care outcomes, young children’s perspectives related to their social support and clinical experiences remain underrepresented in health research. Indeed, children’s agency has been historically restricted in healthcare and health research. This community-engaged, artsbased, qualitative study used Draw-and-Tell Conversations—a participatory approach combining drawing, storytelling, and writing—with 12U.S.-based gender-creative children (ages 5–10). Although children’s caregivers completed surveys to contextualize findings, the project highlighted children’s capacity to report on their own experiences. Data were …

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Advancing The Kingdom, Anna Bennett Mar 2026

Advancing The Kingdom, Anna Bennett

The Main Thing Devotional

“Therefore, go and make disciples of all the nations, baptizing them in the name of the Father and the Son and the Holy Spirit. Teach these new disciples to obey all the commands I have given you. And be sure of this: I am with you always, even to the end of the age,” Matthew 28:19-20, NLT.

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Inside 'N Out: Etv2 Specification Of Hemangiogenic Lineages From Flk1+ Mesoderm, Dereck Antonio Shakeel Alleyne Mar 2026

Inside 'N Out: Etv2 Specification Of Hemangiogenic Lineages From Flk1+ Mesoderm, Dereck Antonio Shakeel Alleyne

Arts & Sciences Graduate Student Theses and Dissertations

The cardiovascular system is generated by mesodermal progenitors that give rise to endothelial, hematopoietic and muscle (smooth muscle and cardiomyocyte) lineages. Although vascular endothelial growth factor (VEGF), its receptor, FLK1/KDR and the transcription factor ETV2 are critically required for hemangiogenic specification, Flk1 and Etv2 expression has been observed in other mesodermal derivatives. During gastrulation, mesodermal progenitors are specified to contribute to the cardiovascular system; however, the early divergence of hemangiogenic and muscle progenitors, and their shared marker expression, complicates identification of common mesoderm progenitor populations contributing to both lineages. In this dissertation, I demonstrate how Flk1+ and Etv2+ lineage relationships …

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Multiplex Functional Assessment Of Variant Effect In The Retinal Transcription Factor Crx, James Lewis Shepherdson Mar 2026

Multiplex Functional Assessment Of Variant Effect In The Retinal Transcription Factor Crx, James Lewis Shepherdson

Arts & Sciences Graduate Student Theses and Dissertations

The transcription factor Cone-Rod Homeobox (CRX) is a master regulator of photoreceptor cell fate. Sequence variants in CRX can cause Retinitis Pigmentosa, Cone-Rod Dystrophy, and Leber Congenital Amaurosis, all inherited causes of vision loss and blindness. CRX is the only gene implicated in the pathogenesis of all three of these diseases, which present with both rod- and cone-centric phenotypes of varying age of onset and severity. Several CRX variants have been reported to cause severe dominant disease through antimorphic genetic interactions with wild-type CRX, and yet these mutations are adjacent to variants which are benign or only cause mild, recessive …

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Ribosomal Stress In The Pathogenesis And Treatment Of T-Cell Acute Lymphoblastic Leukemia, Kimberly Bridget Johansson Mar 2026

Ribosomal Stress In The Pathogenesis And Treatment Of T-Cell Acute Lymphoblastic Leukemia, Kimberly Bridget Johansson

Arts & Sciences Graduate Student Theses and Dissertations

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy in which activating mutations in the Notch pathway are thought to contribute to transformation, in part, through activation of c-Myc. Increased expression of c-Myc induces oncogenic stress that can lead to apoptosis through the Mdm2-p53 tumor suppressor pathway. Since the great majority of T-ALL cases maintain wildtype MDM2 and TP53, we hypothesized that T-ALL cells are selectively sensitive to MDM2 inhibition. Treatment with idasanutlin, an MDM2 inhibitor, although only inducing modest apoptosis in T-ALL cells, resulted in a significant upregulation of pro-apoptotic BH3 domain genes BAX and BBC3. This prompted …

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