Digital Commons Network^™

Methodological Framework Of Identifying Disruptive Technologies On Emerging Stage: Based On Science, Jianjun Deng, Anrong Liu, Xiaoyang Cao, Ke Zhang, Guangzu Bai, Yue Chen, Zhijie Gao, Haiwen Dai, Weinan Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

To realize sci-tech self-reliance and self-strengthening at higher levels in China, it is imperative for disruptive technologies to embark on a new journey and open new horizons. The layout and development of disruptive technologies is a complicated and systematic project with strategic significance, in which the identification of disruptive technologies holds the key and serves as the premise. To this end, based on the underlying logic that disruptive technologies are destined to transit from marginalized forces to mainstream power in the future through the process of 10→3→1 constringency, on the understanding that the generation of disruptive technologies is driven by …

Developing Science And Technology Policies For High Risk-High Reward Research, Lingjing Cao, Zhiqiang Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

High Risk-High Reward (HRHR) research refers to scientific research with high risk of failure but characterized by breakthrough, innovation and originality. It truly reflects the original innovation ability of science and technology, is committed to bringing major scientific discoveries and technological breakthroughs, and is conducive to accelerating the improvement of national competitiveness in original science and technology. The theoretical and methodological research in this area will help improve science and technology policies. On the basis of clarifying its development background, conceptual connotation and characteristics, this paper discusses the construction of a "decision-fundingimplementation" model of HRHR research and management system. By …

National Innovation Force Measurement And International Comparison: 2006–2020, Kaihua Chen, Chao Zhang, Xiaoyu Xue

Bulletin of Chinese Academy of Sciences (Chinese Version)

Based on the innovation value chain, this study establishes the "three horizontal and two vertical dimensions" measurement framework of National Innovation Force, which has a science-technology-industry horizontal dimension and a strength-effectiveness vertical dimension. The framework realizes a comprehensive analysis of National Innovation System from different perspectives and supports the categorized research and differentiated implementation of innovation policies and strategies. The framework considers the differences in science, technology, and innovation activities, as well as those between strength and effectiveness. Based on the analysis of 35 countries in The Report of National Innovation Force Measurement and International Comparison completed by the authors, …

On Deep Integration Of Party Building And Scientific Research Endeavors In Research Institutes, Changhong Nie, Bingguo Jiang, Baoyu Jia

Bulletin of Chinese Academy of Sciences (Chinese Version)

Promoting the deep integration of Party building and scientific research endeavors in research institutes is an important measure to strengthen the Party's overall leadership over the development of science and technology, implement the requirement of full and strict governance of the Party, improve the effectiveness of Party building in research institutes, and advance the modernization of the governance system and capacity of research institutes. This study adopts the perspective of innovation management and discusses the theoretical basis for promoting the deep integration of Party building and scientific research endeavors in research institutes. On the basis of studying and reviewing the …

Very First Meeting Of First Youth Editorial Committee For Bulletin Of Chinese Academy Of Sciences Was Held In Beijing

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

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Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

2022 Issue5 Content

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Butterfly Pattern: Innovative Exploration Of Scientific Research Paradigm In Era Of Big Science—Based On 15-Year Practice Of Integrated Development Of Science And Industry In Shenzhen Institute Of Advanced Technology (Siat), Chinese Academy Of Sciences, Jianping Fan

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the era of big science, the innovation chain and the industry chain are deeply integrated, promoting the continuous evolution of the underlying logic of the "linear model" and the "Pasteur's quadrant". The world scientific research is gradually evolving to the collaborative interaction of innovative subjects and the system integration of various elements. On the basis of in-depth exploration of the linear model and Pasteur's quadrant, SIAT focuses on creating a closed-loop ecology of the innovation chain and industrial chain. By integrating science and industry from design to advancing, SIAT has built a "butterfly pattern", which integrates and reconstructs the …

The Experiences Of International Graduate Students From Latin America In Their Transition Of Graduating And Finding A Job In The United States, Natalia Hernandez

Master's Theses

The purpose of this thesis project is to conduct a qualitative phenomenological study to understand the lived experiences of international graduate students from Latin America in the United States as they transition from their studies to finding a full-time job in the United States. The most common themes mentioned in the different sections of the interviews were: the different dynamics in their identity, the benefits, and limitations of their status in the American context, and how their professional development and economy are impacted while being international graduate students from Latin America. Student service departments such as the Career Service department, …

Save Lives And Sanitize: Prevention Of Surgical Site Infections Post-Cesarean Section Through Increased Hand Hygiene Compliance, Lindsay N. Nance

Master's Projects and Capstones

Problem: Surgical site infections (SSIs) occur in 3-15% of cesarean sections, making SSIs one of the most common hospital-acquired infections (HAIs). Surgical site infections (SSIs) have increased within a Labor & Delivery (L&D) unit in a large California teaching hospital for the past three years, affecting reimbursement and creating a range of adverse outcomes for patients. Performance of consistent and thorough hand hygiene practices is key to preventing infection, yet the unit’s hand hygiene compliance of 66.7% is well below the facility’s target goal of 90%. Based on recommendations from the organization’s Infection Prevention & Control (IPC) specialist, the …

In “Plane” Sight: A Study Of Sfo’S Human Trafficking Intervention Sticker, Kendall R. Anderson

Master's Projects and Capstones

Human trafficking is a growing problem globally. Recent data indicates that airports are one of the few locations that victims can be identified and removed from a human trafficking situation. As a result, US airports have been working to raise awareness through public campaigns and employee trainings. The San Francisco International Airport, for example, created a campaign that directly appeals to victims in private spaces. To understand the effectiveness and implications of the campaign, I ask the following research question: how is the SFO campaign constructed to intervene in human trafficking? What are the limits and possibilities of this campaign? …

Implementing Aidet And Commit To Sit To Increase Patient Satisfaction In The Pediatric Outpatient Setting, Tiffany Nguyen

Master's Projects and Capstones

Problem: This quality improvement initiative aims to implement AIDET, Commit to Sit, and culturally competent care in a pediatric outpatient surgery clinic to increase patient satisfaction. The microsystem falls beneath the 85th percentile of patient satisfaction scores on their unit. They have a pre-intervention Net Promoter Score (NPS) of 80.7, indicating about 80% of patients were "promoters" and would likely return to the clinic, and 20% of patients were "detractors" and unlikely to return (Appendix F). "Detractors" were found in areas including patients trusting providers with care, care providers listening, care providers explaining things, and patients recommending the facility to …

The Future Of Soes : Part – Iii, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

A detailed and rigorous exercise was undertaken to examine each SOE based on the ownership rationale and its financial performance as explained earlier, and all the commercial SOEs were categorized into two broad categories: (a) to be retained under state ownership; and (b) to be privatized or liquidated. The first category includes those performing core functions and fall within the scope of public policy framework. These SOEs are further sub-divided into two parts according to their financial performance: one, those which are profitable and financially viable – 25 SOEs were profitable in FY2018-19. Using a more stringent criteria to evaluate …

Definition Of Germ Layer Cell Lineage Alternative Splicing Programs Reveals A Critical Role For Quaking In Specifying Cardiac Cell Fate, W Samuel Fagg, Naiyou Liu, Ulrich Braunschweig, Karen Larissa Pereira De Castro, Xiaoting Chen, Frederick S Ditmars, Steven G Widen, John Paul Donohue, Katalin Modis, William K Russell, Jeffrey H Fair, Matthew T Weirauch, Benjamin J Blencowe, Mariano A Garcia-Blanco

Faculty, Staff and Student Publications

Alternative splicing is critical for development; however, its role in the specification of the three embryonic germ layers is poorly understood. By performing RNA-Seq on human embryonic stem cells (hESCs) and derived definitive endoderm, cardiac mesoderm, and ectoderm cell lineages, we detect distinct alternative splicing programs associated with each lineage. The most prominent splicing program differences are observed between definitive endoderm and cardiac mesoderm. Integrative multi-omics analyses link each program with lineage-enriched RNA binding protein regulators, and further suggest a widespread role for Quaking (QKI) in the specification of cardiac mesoderm. Remarkably, knockout of QKI disrupts the cardiac mesoderm-associated alternative …

Three-Dimensional Evaluation Of Isodose Radiation Volumes In Cases Of Severe Mandibular Osteoradionecrosis For The Prediction Of Recurrence After Segmental Resection, Haye H Glas, Joep Kraeima, Silke Tribius, Frank K J Leusink, Carsten Rendenbach, Max Heiland, Carmen Stromberger, Ashkan Rashad, Clifton D Fuller, Abdallah S R Mohamed, Stephen Y Lai, Max J H Witjes

Faculty, Staff and Student Publications

Background: Pre-operative margin planning for the segmental resection of affected bone in mandibular osteoradionecrosis (ORN) is difficult. The aim of this study was to identify a possible relation between the received RT dose, exposed bone volume and the progression of ORN after segmental mandibular resection.

Method: Patients diagnosed with grade 3-4 ORN for which a segmental resection was performed were included in the study. Three-dimensional reconstructions of RT isodose volumes were fused with postoperative imaging. The primary outcome was the recurrence of ORN after segmental resection. Subsequently, RT exposed mandibular bone volumes were calculated and the location of the bone …

Tite-Boin12: A Bayesian Phase I/Ii Trial Design To Find The Optimal Biological Dose With Late-Onset Toxicity And Efficacy, Yanhong Zhou, Ruitao Lin, J Jack Lee, Daniel Li, Li Wang, Ruobing Li, Ying Yuan

Faculty, Staff and Student Publications

In the era of immunotherapies and targeted therapies, the focus of early phase clinical trials has shifted from finding the maximum tolerated dose to identifying the optimal biological dose (OBD), which maximizes the toxicity-efficacy trade-off. One major impediment to using adaptive designs to find OBD is that efficacy or/and toxicity are often late-onset, hampering the designs’ real-time decision rules for treating new patients. To address this issue, we propose the model-assisted TITE-BOIN12 design to find OBD with late-onset toxicity and efficacy. As an extension of the BOIN12 design, the TITE-BOIN12 design also uses utility to quantify the toxicity-efficacy trade-off. We …

Gli1 Activates Pro-Fibrotic Pathways In Myelofibrosis Fibrocytes, Taghi Manshouri, Ivo Veletic, Ping Li, C Cameron Yin, Sean M Post, Srdan Verstovsek, Zeev Estrov

Faculty, Staff and Student Publications

Bone marrow (BM) fibrosis was thought to be induced exclusively by mesenchymal stromal cells (MSCs). However, we and others found that neoplastic fibrocytes induce BM fibrosis in myelofibrosis (MF). Because glioma-associated oncogene-1 (GLI1), an effector of the Hedgehog pathway, plays a role in the induction of BM fibrosis, we wondered whether GLI1 affects fibrocyte-induced BM fibrosis in MF. Multiplexed fluorescence immunohistochemistry analysis of MF patients' BM detected high levels of GLI1 in MF fibrocytes compared to MSCs or normal fibrocytes. Immunostaining, RNA in situ hybridization, gene expression analysis, and western immunoblotting detected high levels of GLI1 and GLI1-induced matrix metalloproteases …

Pirtobrutinib Inhibits Wild-Type And Mutant Bruton’S Tyrosine Kinase-Mediated Signaling In Chronic Lymphocytic Leukemia, Burcu Aslan, Gorkem Kismali, Lakesla R Iles, Ganiraju C Manyam, Mary L Ayres, Lisa S Chen, Mihai Gagea, Maria Teresa Sabrina Bertilaccio, William G Wierda, Varsha Gandhi

Faculty, Staff and Student Publications

Pirtobrutinib (LOXO-305), a reversible inhibitor of Bruton's tyrosine kinase (BTK), was designed as an alternative strategy to treat ibrutinib-resistant disease that develops due to C481 kinase domain mutations. The clinical activity of pirtobrutinib has been demonstrated in CLL, but the mechanism of action has not been investigated. We evaluated pirtobrutinib in 4 model systems: first, MEC-1, a CLL cell line overexpressing BTKWT, BTKC481S, or BTKC481R; second, murine models driven by MEC-1 overexpressing BTKWT or BTKC481S; third, in vitro incubations of primary CLL cells; and finally, CLL patients during pirtobrutinib therapy (NCT03740529, ClinicalTrials.gov). Pirtobrutinib inhibited BTK activation as well …

Stinging The Predators: A Collection Of Papers That Should Never Have Been Published, Zen Faulkes

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

This ebook collects academic papers and conference abstracts that were meant to be so terrible that nobody in their right mind would publish them. All were submitted to journals and conferences to expose weak or non-existent peer review and other exploitative practices. Each paper has a brief introduction. Short essays round out the collection.

Adverse Radiation Effect And Freedom From Progression Following Repeat Stereotactic Radiosurgery For Brain Metastases, Michael Mcdermott

All Publications

Objective: The authors previously evaluated risk and time course of adverse radiation effects (AREs) following stereotactic radiosurgery (SRS) for brain metastases, excluding lesions treated after prior SRS. In the present analysis they focus specifically on single-fraction salvage SRS to brain metastases previously treated with SRS or hypofractionated SRS (HFSRS), evaluating freedom from progression (FFP) and the risk and time course of AREs.

Methods: Brain metastases treated from September 1998 to May 2019 with single-fraction SRS after prior SRS or HFSRS were analyzed. Serial follow-up magnetic resonance imaging (MRI) and surgical pathology reports were reviewed to score local treatment failure and …

Ceftriaxone Resistance And Adequacy Of Initial Antibiotic Therapy In Community Onset Bacterial Pneumonia, Richard F Van Besien, Nicholas Hampton, Scott T Micek, Marin H Kollef

Open Access Publications

ABSTRACT: Much remains unknown about the impact of initial antibiotic adequacy on mortality in community onset bacterial pneumonia (COBP). Therefore, we performed a study to determine how the adequacy of initial antibiotic therapy affects in-hospital mortality for patients with COBP.We carried out a retrospective cohort study among the 11 BJC Healthcare community and academic hospitals in Missouri and Illinois. The electronic medical records for BJC Healthcare were queried to obtain a set of patient admissions with culture positive (respiratory or blood) COBP admitted from January 1, 2016 through December 31, 2019. Patients with COBP required an International Classification of Diseases …

Individual-Level And Neighborhood-Level Factors Associated With Longitudinal Changes In Cardiometabolic Measures In Participants Of A Clinic-Based Care Coordination Program: A Secondary Data Analysis, Sonal J Patil, Mojgan Golzy, Angela Johnson, Yan Wang, Jerry C Parker, Robert B Saper, Debra Haire-Joshu, David R Mehr, Randi E Foraker, Robin L Kruse

Open Access Publications

BACKGROUND: Identifying individual and neighborhood-level factors associated with worsening cardiometabolic risks despite clinic-based care coordination may help identify candidates for supplementary team-based care.

METHODS: Secondary data analysis of data from a two-year nurse-led care coordination program cohort of Medicare, Medicaid, dual-eligible adults,

RESULTS: 6378 participants had pre-and post-intervention levels reported for at least one outcome measure. In adjusted models, higher pre-intervention cardiometabolic measures were associated with worsening of all cardiometabolic measures. Women had worsening LDL-cholesterol compared with men. Women with pre-intervention HbA1c > 6.8% and systolic blood pressure > 131 mm of Hg had worse post-intervention HbA1c and systolic blood pressure compared …

Untethering The “Other”: Creating Spaces For Black Autonomy And Community, Kaylyn Webster

Bachelor of Fine Arts Senior Papers

By complicating viewers’ relationships to my painted figures through the application of the gaze, my work analyzes how America’s colonial past affects our current landscape to find ways to break the cycle, and to make space for Black autonomy. Blackness should be free to exist without being tethered in a position of inferiority to Whiteness. Radical defiance, resiliency, and expressions of agency have been used by Black people for centuries, and their employment must continue to combat systems of oppression. Our history has been one of division, but mutual respect and cooperation are needed for our communities to stand against …

Active Testing Of Executive Functions: Toward More Efficient And Equitable Individual Behavioral Modeling, Mariluz Rojo Domingo

McKelvey School of Engineering Graduate Student Theses & Dissertations

Inferences about executive functions are commonly drawn through serial administration of various individual assessments that often take a long time to complete and cannot capture complex trends across multiple variables. In an attempt to improve upon current methods used to estimate latent brain constructs, this thesis makes two primary contributions to the field of behavioral modeling. First, it brings attention to sequential designs for more efficient diagnostic testing of fluctuations in executive functions with respect to a baseline level. It was shown that a sequential framework was successfully capable of detecting significant differences in cognitive performance more rapidly than conventional …

Anti-Amyloid Chimeric Antigen Receptor Macrophages For Alzheimer's Disease Immunotherapy, Qiuyun Pan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Alzheimer’s disease is the most common cause of dementia. None of the available drugs can cure the disease. Chimeric Antigen Receptor (CAR) macrophages, because of their phagocytic activity, have potential as a cellular treatment for amyloid aggregation. In this study, we generated an anti-amyloid CAR hematopoietic progenitor cell line. By inducing the progenitor cell line to differentiate into macrophages, we show that the anti-amyloid CAR-Macrophage has enhanced specific phagocytic activity towards amyloid in in vitro experiments. In addition, in ex vivo experiments, anti-amyloid CAR significantly reduces the plaque load on brain slice from APP/PS1 mice when compared to a non-targeted …

Design Of An Offner-Chrisp Imaging Spectrometer For A Planetary Fluorescence Instrument, Tristan Wells Carlson

McKelvey School of Engineering Graduate Student Theses & Dissertations

Spectrometers have been an integral part of space exploration in the late 20th and 21st centuries and will continue to provide quantitative measurements to answer exciting questions like, “Is or was there life on other planets?” PERISCOPE, Probe for Exploring Regolith and Ice by Subsurface Classification of Organics, Polycyclic aromatic hydrocarbons, and Elements, is a next generation spectrometer designed to explore icy worlds like Europa. It uses time-resolved ultraviolet (UV) fluorescence spectroscopy, a technique that identifies organic molecules, polycyclic aromatic hydrocarbons (PAH), and rare earth elements (REE). Photon wavelength discrimination is very important for this technique and is accomplished by …

„Kopfschmerzen, Familiensorgen": Urszenen-Konfigurationen, Psychotherapie-Parodie Und Sublimierungspraktiken In Kafkas "Proceß", Anna Lynn Dolman

Arts & Sciences Graduate Student Theses and Dissertations

The thesis presents a re-reading of Kafka's novel "The Trial" against the background of Kafka's negotiation of Freudian psychoanalysis. Rather than merely employing the Freudian framework as a hermeneutic tool, the thesis argues that Kafka constructs his novel along the lines of psychoanalytic theories while simultaneously attempting to deconstruct them and question the effectiveness of the so-called talking cure by means of ironically subverting a therapeutic configuration. The starting point of the thesis centers on an oftentimes overlooked scene at the very beginning of the novel, arguing that the voyeuristic old couple across the street from K. demonstrate that the …

"The Sound Of The Underground": Distinguishing Alternative Identity In Rap's Contemporary Moment, Jacob P. Cupps

Arts & Sciences Graduate Student Theses and Dissertations

This thesis focuses on transcribing and analyzing a repertory of underground rap songs, examining how the quality of undergroundness manifests within beats and flows. I define underground as a subgenre of hip-hop that is unified by a culture of meditative listening, and I opt for it over related terms because it is style agnostic. Therefore, I am able to investigate how a small set of techniques manifest across a variety of approaches to making underground hip-hop. I argue that these are a way of sounding the underground, communicating meaning to the listener at the level of the song. After an …

Storytelling For A Changing World: Comics As Agitprop, Kruttika Susarla

MFA in Illustration & Visual Culture

This essay imagines fictional storytelling and urban practices of maintenance, repair, and care as interrelated to one another. They are both practices engaged in building a better world. Urban scholars like Gautam Bhan, Shannon Mattern, and David Harvey propose the city as a space for envisioning the kind of community we want to be—a space for working towards our collective future. By engaging in fictional storytelling, I argue, we are doing the same thing: the dual work of taking from fact and representing it to an audience while also engaging in imagining and world-building. This is also a practice of …

The Wizard's Alphabet Book: Illustration As Counter-Environment To The Digital World, Stephen Barany

MFA in Illustration & Visual Culture

This thesis essay accompanies a built installation of twenty-six densely drawn illustrations, each consisting of numerous creatures and objects whose names all begin with the same letter. Thus, each illustration represents a different letter of the alphabet. Printed on cloud-shaped substrates and suspended as a group in a 10”x10” ring, the array of illustrations form a small space where viewers can immerse themselves in the act of free and careful looking. This essay elaborates on the ideas that propelled the design and construction of this illustrated installation.

This essay explores the potential for illustration to create a space for looking …