Digital Commons Network^™

Out-Of-Plane Load-Bearing And Mechanical Energy Absorption Properties Of Flexible Density-Graded Tpu Honeycombs, Ibnaj Anamika Anni, Kazi Zahir Uddin, Nicholas Pagliocca, Nand Singh, Oyindamola Rahman, George Youssef, Behrad Koohbor

Henry M. Rowan College of Engineering Departmental Research

Honeycomb structures are widely used in applications that require excellent strain energy mitigation at low structural weights. The load-bearing and energy absorption capacity of honeycomb structures strongly depend on their cell wall thickness to edge ratios. This work studies the mechanical response and strain energy absorption characteristics of hexagonal honeycomb structures with various cell wall thicknesses in response to out-of-plane loading conditions. Honeycomb structures with various nominal densities are first additively manufactured from flexible thermoplastic polyurethane (TPU). A comprehensive experimental study characterized the mechanical strength, energy absorption performance, and the strain recoverability of the structures. Density-graded structures are then fabricated …

Employee Policy Handbook August 2022, Sacred Heart University

Handbooks & Factbooks

No abstract provided.

The Avenger - August 2022, Naval Air Station Fort Lauderdale Museum

The Avenger

No abstract provided.

Tennessee Child Welfare Practice Model, Tennessee. Department Of Children's Services

Tennessee Child Welfare Practice Model

Published August 1, 2022. The Practice Model is a set of guidelines that capture the organizational values, structures, mechanisms, tools, and skills needed to successfully implement the mission of the Department of Children's Services.

Revenue Collections, August 2022, Tennessee. Department Of Revenue

2022 Revenue Collection Reports

No abstract provided.

Approvals And Prices Of Systemic Antibiotics In Saudi Arabia And The United States, Saad Alharthi

Pharmaceutical Sciences (MS) Theses

Introduction

Antibiotics is one of the therapeutic classes with the highest level of consumption in the world. Despite the global diffusion of antibiotics, their availability and prices vary by country. This study assessed differences in the availability and prices of systemic antibiotics marketed in the United States (US) and Saudi Arabia and evaluated the factors associated with the differences in prices of systemic antibiotics marketed in both countries.

Material and Methods

We collected regulatory data from the US Food and Drug Administration (FDA) and the Saudi Food and Drug Authority (SFDA), the National Average Drug Acquisition Cost (NADAC) and the …

Reviewing The Ethics And Philosophy Behind Social Media's Crowdsourced Panopticon, Amanda Furiasse

Humanities and Politics Faculty Articles

Philosopher Jeremy Weissman theorizes a new approach to social media surveillance by utilizing a familiar theoretical model: the Panopticon. In effect, Weissman argues that social media has transformed ordinary people into prison guards within the Panopticon's public watchtower and endowed ordinary individuals with the power to track, survey, and discipline elite officials, once shielded from public scrutiny. This new power, however, comes with a catch. Social media subsumes individuals within an anonymous, de-individualized public, which erases individual difference while simultaneously and paradoxically promising to amplify that very difference. This review critically examines this paradoxical tension and the ethical concerns and …

Application Of Sulfur Sad To Small Crystals With A Large Asymmetric Unit And Anomalous Substructure, Tung Chung Mou, Baisen Zeng, Tzanko I. Doukov, Stephen R. Sprang

Biological Sciences Faculty Publications

The application of sulfur single-wavelength anomalous dispersion (S-SAD) to determine the crystal structures of macromolecules can be challenging if the asymmetric unit is large, the crystals are small, the size of the anomalously scattering sulfur structure is large and the resolution at which the anomalous signals can be accurately measured is modest. Here, as a study of such a case, approaches to the SAD phasing of orthorhombic Ric-8A crystals are described. The structure of Ric-8A was published with only a brief description of the phasing process [Zeng et al. (2019), Structure, 27, 1137-1141]. Here, alternative approaches to determining the 40-atom …

Motivations For Women In Stem Pursuing Higher Education, Karin Moore

Education Division Scholarship

No abstract provided.

Saket Chaudhari V. Matthew Parker

2022 Decisions

USDC for the District of New Jersey

Dominique Diorio V. Laurel Harry

2022 Decisions

USDC for the Middle District of Pennsylvania

Evaluation Of The Time To Ask Program At St. Croix Regional Family Health Center, Mary Lindsey Smith Phd, Evelyn Ali Bs, Tyler Egeland Ba

Substance Use Research & Evaluation

The goals of the Time to Ask (TTA) education and quality improvement program are to increase the capacity of the interprofessional care team to effectively, efficiently and compassionately discuss alcohol use with their patients through screening, brief intervention, and referral (SBIRT) as well as to expand regular screening and monitoring of unhealthy alcohol use at the practices. This infographic is a summary of a participant feedback following the TTA program at St. Croix Regional Family Health Center. For more information, please contact Lindsey Smith at [email protected]

The Unity Of Hobbes’S Philosophy: Science, Politics, And God?, Zachary Vereb

Faculty and Student Publications

This paper re-examines the dispute concerning Hobbes’s religious beliefs in light of his natural philosophy. First, I argue that atheistic readings of Hobbes can be more plausibly defended provided interpreters make use of a methodological unity thesis. Second, I suggest that theistic readers of Hobbes have good reason to favor the autonomy thesis. I conclude by highlighting how a re-examination of the theism dispute motivates reconsideration of the role of Hobbes’s natural philosophy and scientific methodology vis à vis politics. Maintaining the unity thesis as a methodological device can shed important light on the politics and methods of Leviathan. More …

Scalable Relevance Ranking Algorithm Via Semantic Similarity Assessment Improves Efficiency Of Medical Chart Review, Tianrun Cai, Zeling He, Chuan Hong, Yichi Zhang, Yuk Lam Ho, Jacqueline Honerlaw, Alon Geva, Vidul Ayakulangara Panickan, Amanda King, David R. Gagnon, Michael Gaziano, Kelly Cho, Katherine Liao, Tianxi Cai

Computer Science and Statistics Faculty Publications

Objective: Accurately assigning phenotype information to individual patients via computational phenotyping using Electronic Health Records (EHRs) has been seen as the first step towards enabling EHRs for precision medicine research. Chart review labels annotated by clinical experts, also known as “gold standard” labels, are essential for the development and validation of computational phenotyping algorithms. However, given the complexity of EHR systems, the process of chart review is both labor intensive and time consuming. We propose a fully automated algorithm, referred to as pGUESS, to rank EHR notes according to their relevance to a given phenotype. By identifying the most relevant …

2022-2023 Lindenwood University Undergraduate Course Catalog, Lindenwood University

Course Catalogs

Lindenwood University Undergraduate Course Catalog

Genealib Archive 2022-08, Genealib

GENEALIB Archive

No abstract provided.

Examining The Diagnostic Yield Of Tumour Testing And Qualifying Germline Concordance For Hereditary Cancer Variants In Patients With High-Grade Serous Carcinoma, Emily A. Goebel, Jennifer Kerkhof, Oleksandra Dzyubak, C. Meg Mclachlin, Jacob Mcgee, Bekim Sadikovic

Obstetrics & Gynaecology Publications

Despite advances in treatment, prognosis for most patients with high-grade serous carcinoma (HGSC) remains poor. Genomic alterations in the homologous recombination (HR) pathway are used for cancer risk assessment and render tumours sensitive to platinum-based chemotherapy and poly (ADP-ribose) polymerase inhibitors (PARPi), which can be associated with more favourable outcomes. In addition to patients with tumours containing BRCA1 or BRCA2 pathologic variants, there is emerging evidence that patients with tumours harbouring pathologic variants in other HR genes may also benefit from PARPi therapy. The objective of this study is to assess the feasibility of primary-tumour testing by examining the concordance …

Adapting Despite “Walls Coming Down”: Healthcare Providers’ Experiences Of Covid-19 As An Implosive Adaptation, Sayra Cristancho, Emily Field, Taryn Taylor

Obstetrics & Gynaecology Publications

Introduction: The COVID-19 pandemic has been a daunting exercise in adaptation for healthcare providers. While we are beginning to learn about the challenges faced by teams during the COVID-19 pandemic, what remains underexplored are the strategies team members used to adapt to these challenges. The goal of this study is therefore to explore how healthcare providers navigated and adapted to on-the-ground challenges imposed by COVID-19. Methods: We interviewed 20 healthcare workers at various hospitals in Ontario, who provided care as part of clinical teams during the COVID-19 pandemic. Data were collected and analyzed following Constructivist Grounded Theory principles including iteration, …

The Ability Of Sweat And Buffer Solutions To Reduce Hexavalent Chromium Of Relevance For Leather Extraction, Alexandra Wright, Lila Laundry-Mottiar, Yolanda Hedberg

Chemistry Publications

The European Union restricted the amount of hexavalent chromium (Cr(VI)) in leather in 2015, but skin allergy cases due to Cr-tanned leather are not declining. Standardized extraction methods have been criticized to both over- and underestimate the expected amount of bioavailable Cr(VI) in leather. This study aims to evaluate the ability of four extraction solutions to reduce or preserve Cr(VI): artificial sweat solutions (ASWs) of pH 4.7, 6.5, and 8.0, and phosphate buffer (PB) of pH 8.0. This was investigated by incubating each solution with added Cr(VI) as a function of time, and then measuring the recovered Cr(VI). All solutions, …

Caliper: A Software For Blood-Free Parametric Patlak Mapping Using Pet/Mri Input Function, Praveen Dassanayake, Lumeng Cui, Elizabeth Finger, Matthew Kewin, Jennifer Hadaway, Andrea Soddu, Bjoern Jakoby, Sven Zuehlsdorf, Keith S.St Lawrence, Gerald Moran, Udunna C. Anazodo

Paediatrics Publications

Routine clinical use of absolute PET quantification techniques is limited by the need for serial arterial blood sampling for input function and more importantly by the lack of automated pharmacokinetic analysis tools that can be readily implemented in clinic with minimal effort. PET/MRI provides the ability for absolute quantification of PET probes without the need for serial arterial blood sampling using image-derived input functions (IDIFs). Here we introduce caliPER, a modular and scalable software for simplified pharmacokinetic modeling of PET probes with irreversible uptake or binding based on PET/MR IDIFs and Patlak Plot analysis. caliPER generates regional values or parametric …

Sex And Gender Differences In Symptoms Of Early Psychosis: A Systematic Review And Meta-Analysis, Brooke Carter, Jared Wootten, Suzanne Archie, Amanda L Terry, Kelly K. Anderson

Epidemiology and Biostatistics Publications

First-episode psychosis (FEP) can be quite variable in clinical presentation, and both sex and gender may account for some of this variability. Prior literature on sex or gender differences in symptoms of psychosis have been inconclusive, and a comprehensive summary of evidence on the early course of illness is lacking. The objective of this study was to conduct a systematic review and meta-analysis of the literature to summarize prior evidence on the sex and gender differences in the symptoms of early psychosis. We conducted an electronic database search (MEDLINE, Scopus, PsycINFO, and CINAHL) from 1990 to present to identify quantitative …

Parents’ Perceptions Of Their Children’S Physical Activity During The Covid-19 Pandemic, Emma Ostermeier, Patricia Tucker, Danielle Tobin, Andrew Clark, Jason Gilliland

Geography & Environment Publications

Background

COVID-19 has drastically changed the everyday lives of children, including limiting interactions with peers, loss of regularly organized activities, and closure of schools and recreational facilities. While COVID-19 protocols are in place to reduce viral transmission, they have affected children’s access to physical activity opportunities. The purpose of this study was to understand how COVID-19 has affected children’s engagement in physical activity and to identify strategies that can support children’s return to physical activity programming in public places.

Methods

Parents of past participants in the Grade 5 ACT-i-Pass Program in London, Ontario, Canada were invited to participate in a …

2022 Canadian Cardiovascular Society Guideline For Use Of Glp-1 Receptor Agonists And Sglt2 Inhibitors For Cardiorenal Risk Reduction In Adults, G.B. John Mancini, Eileen O'Meara, Shelley Zieroth, Mathieu Bernier, Alice Y.Y. Cheng, David Z.I. Cherney, Kim A. Connelly, Justin Ezekowitz, Ronald M. Goldenberg, Lawrence A. Leiter, Gihad Nesrallah, Breay W. Paty, Marie-Eve Piche, Peter Senior, Abhinav Sharma, Subodh Verma, Vincent Woo, Pol Darras, Jonathan Y. Gabor, Jean Gregoire, Eva Lonn, James A. Stone, Jean-Francois Yale, Colin Yeung, Deborah Zimmerman

Department of Medicine Publications

This guideline synthesizes clinical trial data supporting the role of glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter 2 inhibitors (SGLT2i) for treatment of heart failure (HF), chronic kidney disease, and for optimizing prevention of cardiorenal morbidity and mortality in patients with type 2 diabetes. It is on the basis of a companion systematic review and meta-analysis guided by a focused set of population, intervention, control, and outcomes (PICO) questions that address priority cardiorenal end points. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system and a modified Delphi process were used. We encourage comprehensive assessment of cardiovascular (CV) patients …

Interleukin 15 Modulates The Effects Of Poly I:C Maternal Immune Activation On Offspring Behaviour, Faraj L. Haddad, Salonee V. Patel, Ella E. Doornaert, Cleusa De Oliveira, Brian L. Allman, Kelly J. Baines, Stephen J. Renaud, Susanne Schmid

Neuroscience Institute Publications

Maternal infections during pregnancy are linked with an increased risk for disorders like Autism Spectrum Disorder and schizophrenia in the offspring. Although precise mechanisms are still unclear, clinical and preclinical evidence suggest a strong role for maternal immune activation (MIA) in the neurodevelopmental disruptions caused by maternal infection. Previously, studies using the Polyinosinic:Polycytidylic (Poly I:C) MIA preclinical model showed that cytokines like Interleukin 6 (Il6) are important mediators of MIA's effects. In this study, we hypothesized that Il15 may similarly act as a mediator of Poly I:C MIA, given its role in the antiviral immune response. To test this hypothesis, …

Number Symbols Are Processed More Automatically Than Nonsymbolic Numerical Magnitudes: Findings From A Symbolic-Nonsymbolic Stroop Task, H. Moriah Sokolowski, Zachary Hawes, Tali Leibovich-Raveh, Daniel Ansari

Neuroscience Institute Publications

Are number symbols (e.g., 3) and numerically equivalent quantities (e.g., •••) processed similarly or distinctly? If symbols and quantities are processed similarly then processing one format should activate the processing of the other. To experimentally probe this prediction, we assessed the processing of symbols and quantities using a Stroop-like paradigm. Participants (NStudy1 = 80, NStudy2 = 63) compared adjacent arrays of symbols (e.g., 4444 vs 333) and were instructed to indicate the side containing either the greater quantity of symbols (nonsymbolic task) or the numerically larger symbol (symbolic task). The tasks included congruent trials, where the greater symbol and quantity …

Mechanisms And Biomarker Potential Of Extracellular Vesicles In Stroke, Nikita Ollen-Bittle, Austyn D. Roseborough, Wenxuan Wang, Jeng Liang D. Wu, Shawn N. Whitehead

Neuroscience Institute Publications

Stoke is a prevalent and devastating neurologic condition with limited options for therapeutic management. Since brain tissue is rarely accessible clinically, peripheral biomarkers for the central nervous system’s (CNS’s) cellular response to stroke may prove critical for increasing our understanding of stroke pathology and elucidating novel therapeutic targets. Extracellular vesicles (EVs) are cell-derived, membrane-enclosed vesicles secreted by all cell types within the CNS that can freely pass the blood-brain barrier (BBB) and contain unique markers and content linked to their cell of origin. These unique qualities make brain-derived EVs novel candidates for non-invasive blood-based biomarkers of both cell specificity and …

Lockdown, Bottoms Up? Changes In Adolescent Substance Use Across The Covid-19 Pandemic, Tara M. Dumas, Wendy E. Ellis, Stephen Van Hedger, Dana M. Litt, Madeleine Macdonald

Neuroscience Institute Publications

The COVID-19 pandemic notably altered adolescent substance use during the initial stage (Spring 2020) of the pandemic. The purpose of this longitudinal study is to examine trajectories of adolescent substance use across the pandemic and subsequent periods of stay-at-home orders and re-opening efforts. We further examined differences as a function of current high school student versus graduate status. Adolescents (n = 1068, 14–18 years, Mage = 16.95 years and 76.7% female at T1) completed 4 different self-report surveys, starting during the first stay-at-home order and ending approximately 14 months later. Negative binomial hurdle models predicted: (1) the likelihood of no …

International Union Of Angiology (Iua) Consensus Paper On Imaging Strategies In Atherosclerotic Carotid Artery Imaging: From Basic Strategies To Advanced Approaches, Luca Saba, Pier Luigi Antignani, Ajay Gupta, Riccardo Cau, Kosmas I. Paraskevas, Pavel Poredos, Bruce Wasserman, Hooman Kamel, Efthymios D. Avgerinos, Rodrigo Salgado, Federico Caobelli, Leonardo Aluigi, Luis Savastano, Martin Brown, Tom Hatsukami, Emad Hussein, Jasjit S. Suri, Armado Mansilha, Max Wintermark, Daniel Staub, Jose Fernandes Montequin, Ruben Tomas Toro Rodriguez, Niranjan Balu, Jan Pitha, M. Eline Kooi, Brajesh K. Lal, J. David Spence, Giuseppe Lanzino, Hugh Stephen Marcus, Marcello Mancini

Neuroscience Institute Publications

Cardiovascular disease (CVD) is the leading cause of mortality and disability in developed countries. According to WHO, an estimated 17.9 million people died from CVDs in 2019, representing 32% of all global deaths. Of these deaths, 85% were due to major adverse cardiac and cerebral events. Early detection and care for individuals at high risk could save lives, alleviate suffering, and diminish economic burden associated with these diseases. Carotid artery disease is not only a well-established risk factor for ischemic stroke, contributing to 10%–20% of strokes or transient ischemic attacks (TIAs), but it is also a surrogate marker of generalized …

Tonic Pain Alters Functional Connectivity Of The Descending Pain Modulatory Network Involving Amygdala, Periaqueductal Gray, Parabrachial Nucleus And Anterior Cingulate Cortex, Timothy J. Meeker, Anne Christine Schmid, Michael L. Keaser, Shariq A. Khan, Rao P. Gullapalli, Susan G. Dorsey, Joel D. Greenspan, David A. Seminowicz

Neuroscience Institute Publications

Introduction: Resting state functional connectivity (FC) is widely used to assess functional brain alterations in patients with chronic pain. However, reports of FC accompanying tonic pain in pain-free persons are rare. A network we term the Descending Pain Modulatory Network (DPMN) is implicated in healthy and pathologic pain modulation. Here, we evaluate the effect of tonic pain on FC of specific nodes of this network: anterior cingulate cortex (ACC), amygdala (AMYG), periaqueductal gray (PAG), and parabrachial nuclei (PBN). Methods: In 50 pain-free participants (30F), we induced tonic pain using a capsaicin-heat pain model. functional MRI measured resting BOLD signal during …

Feasibility And Safety Of Combining Repetitive Transcranial Magnetic Stimulation And Quadriceps Strengthening Exercise For Chronic Pain In Knee Osteoarthritis: A Study Protocol For A Pilot Randomised Controlled Trial, Wei Ju Chang, Sam Adie, Justine M. Naylor, Nahian Chowdhury, Harrison Finn, Rodrigo R.N. Rizzo, Edel O'Hagan, Siobhan M. Schabrun

Neuroscience Institute Publications

Introduction Knee osteoarthritis is a leading cause of disability, resulting in pain and reduced quality of life. Exercise is the cornerstone of conservative management but effects are, at best, moderate. Early evidence suggests that repetitive transcranial magnetic stimulation (rTMS) applied over the primary motor cortex (M1) may improve the effect of exercise in knee osteoarthritis. This pilot study aims to (1) determine the feasibility, safety and participant-rated response to an intervention adding M1 rTMS to exercise in knee osteoarthritis; (2) elucidate physiological mechanisms in response to the intervention; (3) provide data to conduct a sample size calculation for a fully …