Digital Commons Network^™

Targeted Copy Number Variant Identification Across The Neurodegenerative Disease Spectrum, Allison A. Dilliott, Kristina K. Zhang, Jian Wang, Agessandro Abrahao, Malcolm A. Binns, Sandra E. Black, Michael Borrie, Dar Dowlatshahi, Elizabeth Finger, Corinne E. Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Sanjeev Kumar, Anthony E. Lang, Jennifer Mandzia, Mario Masellis, Stephen H. Pasternak, Bruce G. Pollock, Tarek K. Rajji, Ekaterina Rogaeva, Demetrios J. Sahlas, Gustavo Saposnik, Christine Sato, Dallas Seitz, Christen Shoesmith, Thomas D.L. Steeves, Richard H. Swartz

Neuroscience Institute Publications

Background: Although genetic factors are known to contribute to neurodegenerative disease susceptibility, there remains a large amount of heritability unaccounted for across the diagnoses. Copy number variants (CNVs) contribute to these phenotypes, but their presence and influence on disease state remains relatively understudied. Methods: Here, we applied a depth of coverage approach to detect CNVs in 80 genes previously associated with neurodegenerative disease within participants of the Ontario Neurodegenerative Disease Research Initiative (n = 519). Results: In total, we identified and validated four CNVs in the cohort, including: (1) a heterozygous deletion of exon 5 in OPTN in an Alzheimer's …

Machine Learning-Based Predictive Modeling Of Resilience To Stressors In Pregnant Women During Covid-19: A Prospective Cohort Study, Emily S. Nichols, Harini S. Pathak, Roberta Bgeginski, Michelle F. Mottola, Isabelle Giroux, Ryan J. Van Lieshout, Yalda Mohsenzadeh, Emma G. Duerden

Neuroscience Institute Publications

During the COVID-19 pandemic, pregnant women have been at high risk for psychological distress. Lifestyle factors may be modifiable elements to help reduce and promote resilience to prenatal stress. We used Machine-Learning (ML) algorithms applied to questionnaire data obtained from an international cohort of 804 pregnant women to determine whether physical activity and diet were resilience factors against prenatal stress, and whether stress levels were in turn predictive of sleep classes. A support vector machine accurately classified perceived stress levels in pregnant women based on physical activity behaviours and dietary behaviours. In turn, we classified hours of sleep based on …

The Task Matters: A Scoping Review On Reading Comprehension Abilities In Adhd, Kaitlyn M.A. Parks, Christine N. Moreau, Kara E. Hannah, Leah Brainin, Marc F. Joanisse

Neuroscience Institute Publications

Objective: A broad range of tasks have been used to classify individuals with ADHD with reading comprehension difficulties. However, the inconsistency in the literature warrants a scoping review of current knowledge about the relationship between ADHD diagnosis and reading comprehension ability. Method: A comprehensive search strategy was performed to identify relevant articles on the topic. Thirty-four articles met inclusion criteria for the current review. Results: The evidence as a whole suggests reading comprehension is impaired in ADHD. The most prominent effect was found in studies where participants retell or pick out central ideas in stories. On these tasks, participants with …

Anomia Is Present Pre-Symptomatically In Frontotemporal Dementia Due To Mapt Mutations, Arabella Bouzigues, Lucy L. Russell, Georgia Peakman, Martina Bocchetta, Caroline V. Greaves, Rhian S. Convery, Emily Todd, James B. Rowe, Barbara Borroni, Daniela Galimberti, Pietro Tiraboschi, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, John C. Van Swieten, Harro Seelaar, Lize Jiskoot, Sandro Sorbi, Chris R. Butler, Caroline Graff, Alexander Gerhard, Tobias Langheinrich, Robert Laforce, Raquel Sanchez-Valle, Alexandre De Mendonça, Fermin Moreno, Matthis Synofzik, Rik Vandenberghe, Simon Ducharme, Isabelle Le Ber

Neuroscience Institute Publications

INTRODUCTION: A third of frontotemporal dementia (FTD) is caused by an autosomal-dominant genetic mutation in one of three genes: microtubule-associated protein tau (MAPT), chromosome 9 open reading frame 72 (C9orf72) and progranulin (GRN). Prior studies of prodromal FTD have identified impaired executive function and social cognition early in the disease but few have studied naming in detail. METHODS: We investigated performance on the Boston Naming Test (BNT) in the GENetic Frontotemporal dementia Initiative cohort of 499 mutation carriers and 248 mutation-negative controls divided across three genetic groups: C9orf72, MAPT and GRN. Mutation carriers were further divided into 3 groups according …

What Happened During Covid-19? Instructional Setting As A Predictor Of Student's Academic Achievement, Wil Perkins Ed.D., Usen Akpanudo Ed.D.

Administrative Faculty & Staff Research and Publications

Our goal in the current study was to identify the degree to which instructional setting (remote versus traditional) predicted students’ academic achievement during the COVID-19 pandemic. A matched sample of data from 194 undergraduate students who were continuously enrolled at a private university in the southeastern United States from the spring semester of 2020 through the spring semester of 2021 was selected for this study. Data from students enrolled remotely across 37 majors were matched by sex, enrollment status, and Spring 2020 GPA. Our findings showed that neither instructional setting, students’ sex, nor the number of hours they attempted were …

Complexity In The Classroom Workshop: Teaching And Learning The Cynefin Framework By Applying It To The Classroom, Jennifer Karlin, L. Eric James, Lauren Singlelmann

Integrated Engineering Department Publications

Complex adaptive systems are both an important fundamental principle in systems engineering education and a reality of all engineering education. The Cynefin framework, as created by Snowden and Boone (2007), is a decision-making tool that helps the engineer recognize the type of system within which they are operating and then respond in a manner that is appropriate for the cause-and-effect relationships associated with that system type. The types of system, or the domains, fall into five categories and their liminal spaces: obvious, where the cause-and-effect relationships are clear to everyone involved; complicated, where the cause-and-effect relationships are clear to those …

August/September 2022, Issue 1, James Madison University Student Affairs Communications And Marketing

Potty Mouth

No abstract provided.

The American Dream In Crisis: How Student Debt Impacts The Educational Experiences Of Black Students, Jessie N. Webb

McNair Scholars Manuscripts

In a society riddled with inequities, student debt can be viewed as a crisis for which long term solutions are a necessity. For Black students, student debt has detrimental effects on their overall college experience, including negative implications on their economic status, academic performance, emotional/mental well-being, as well as inhibiting social/civic engagement. This research will highlight the financial disadvantages that Black students undergo, which leads to an oppressive cycle of student debt and limits social mobility. With the stressors of student debt, Black students lose out on engaging socially with peers, as well as having enough time to focus on …

The Role Of Pereceived Racial Discrimination On Help-Seeking Intention And Psychological Distress, Emili Noel Pickenpaugh

Dissertations

Based on their experiences of perceived discrimination, Black, Indigenous, and People of Color (BIPOC) college students should theoretically be in higher need of mental health care services as perceived discrimination often increases psychological distress. However, there is a documented disparity in the utilization of services. The Theory of Planned Behavior (TPB) suggests that those with higher levels of psychological distress should be more likely to seek services. This study analyzed the relationship between race, psychological distress, and perceived racial discrimination as predictors of help-seeking intention, specifically, with the hopes of understanding the potential moderating role perceived racial discrimination plays between …

Understanding Learners' Motivation Through Machine Learning Analysis On Reflection Writing, Elizabeth Pluskwik, Yuezhou Wang, Lauren Singelmann

Integrated Engineering Department Publications

Educational data mining (EDM) is an emerging interdisciplinary field that utilizes a machine learning (ML) algorithm to collect and analyze educational data, aiming to better predict students' performance and retention. In this WIP paper, we report our methodology and preliminary results from utilizing a ML program to assess students’ motivation through their upper-division years in the XYZ project-based learning (PBL) program. ML, or more specifically, the clustering algorithm, opens the door to processing large amounts of student-written artifacts, such as reflection journals, project reports, and written assignments, and then identifies keywords that signal their levels of motivation (i.e., extrinsic vs. …

Working Full Time And Earning An Engineering Degree: Wellbeing In A Co-Op-Based Engineering Program, Catherine Mcgough Spence, Luke Nyberg, Justine Chasmar, Jodi Nelson, Marissa Tsugawa

Integrated Engineering Department Publications

The purpose of this research paper is to describe how stress manifests in undergraduate engineering students who are working in paid engineering positions while completing their upper-division coursework, through the analysis of reflective prompts on wellbeing, and engineering belongingness. Previous research has identified the culture of “suffering and shared hardship” where heavy workloads and stressful situations are expected in engineering programs and engineering as a discipline. Stress, specifically feelings of being overwhelmed with workload, has far reaching implications for an individuals’ wellbeing beyond academic performance.

We focus on the frameworks of self-determination theory, engineering belonging, identity, to better understand undergraduate …

Fire And Human Management Of Late Holocene Ecosystems In Southern Africa, Benjamin Davies, Mitchell J. Power, David R. Braun, Matthew J. Douglass, Stella G. Mosher, Lynne J. Quick, Irene Esteban, Judith Sealy, John Parkington, J. Tyler Faith

School of Natural Resources: Faculty Publications

Globally, fire is a primary agent for modifying environments through the long-term coupling of human and natural systems. In southern Africa, control of fire by humans has been documented since the late Middle Pleistocene, though it is unclear when or if anthropogenic burning led to fundamental shifts in the region's fire regimes. To identify potential periods of broad-scale anthropogenic burning, we analyze aggregated Holocene charcoal sequences across southern Africa, which we compare to paleoclimate records and archaeological data. We show climate-concordant variability in mid-Holocene fire across much of the subcontinent. However, increased regional fire activity during the late Holocene (~2000 …

Secondary Science Teachers Use Of Models In Teaching And Learning About Earth’S Climate, Kimberly Carroll Steward

School of Natural Resources: Dissertations, Theses, and Student Research

Global climate change (GCC) presents unprecedented global concerns, notably food supply limitations, unsustainable use of natural resources, and widespread environmental degradation. The International Panel on Climate Change (IPCC) reports a 0.85 °C increase in global average temperatures between 1880 and 2018 and a 50% increase in global carbon dioxide emissions since 1990 (Stocker et al., 2018). As a result of the urgency of the situation, there is a strong emphasis on empowering citizens through outreach and education. There is a need to adequately prepare the next generation of scientists, politicians, business leaders, and other people; it is crucial to foster …

Interprofessional Education – Occupational Therapy And Eating Disord, Alexis Namyak

Department of Occupational Therapy Entry-Level Capstone Projects

Living with an eating disorder (ED) can strip an individual from experiencing a meaningful life engaging in occupations, tasks, habits, rituals, routines, and roles that were once familiar to oneself prior to their diagnosis. Having an ED can lead to negative behaviors that become maladaptive and obsessive (Wagenfeld & Olson, 2017). Typical treatment for individuals with EDs includes members on an interprofessional (IP) team composed of a primary care physician (PCP), nutritionist, and a mental health professional (Walsh et al., 2000). However, another professional, an occupational therapist (OT), should be included throughout treatment due to their unique contribution to address …

Problem Solving Like A Mathematician: Disciplinary Literacy Instruction In Elementary Mathematics, Charlotte Frambaugh-Kritzer, Stephanie Buelow

Reading Horizons: A Journal of Literacy and Language Arts

This study aims to grow the literature by examining the how of disciplinary literacies (DL) elementary mathematics instructional practices in teacher education, which is under-reported. Using qualitative case study methods, we examined how one cohort of elementary preservice teachers (PTs) enacted the DL instructional practices in their field practicum K–6 classrooms. Using a social constructivism perspective, we combined directed content analysis with real-time dialogue and the writing process as analytical tools to examine our data. Data sources included observation notes from the mathematics methods course, observation notes from the field practicum, and multiple artifacts (e.g., post observation oral and written …

Developing Preservice Teachers’ Critical Literacy Praxis In A Rural Teacher Education Program, Vera Sotirovska, Margaret Vaughn

Reading Horizons: A Journal of Literacy and Language Arts

This research examined preservice teachers’ beliefs about critical literacy praxis in a rural teacher education program. Using qualitative methods, preservice teachers participated in interviews, reflective engagements, and picture book analysis. Thematic analysis was used to understand preservice teacher reflections on critical literacy, structured around discussions about multicultural literature, and preservice teacher experiences with critical literacy practices in their coursework. This article presents preservice teachers’ beliefs on critical literacy praxis.

Teacher Agency As A Route To Adaptive Expertise: Relational, Informed, And Reflective Action, Jennifer Sharples Reichenberg

Reading Horizons: A Journal of Literacy and Language Arts

This case study of two fourth-grade teachers explored teachers’ literacy instructional practices and perceptions of their professional agency during the hybrid synchronous teaching of the COVID-19 pandemic. In anticipation of the challenges of hybrid synchronous instruction, these teachers combined their classes to co-teach 39 students. Analysis of observation and interview data showed that the co-teachers acted as adaptive experts. They reflected on challenges such as maintaining students’ focus, developing rapport, and gaining active participation. Their collaborative reflection informed adaptations to increase students’ access to learning by employing multiple modalities, developing community, and enacting inclusive practices. Teachers also supported students’ agency …

Manufacturing & Service Systems, Robert S. Keyser

KSU Distinguished Course Repository

An analysis of decision making in the current production environment and the tools and optimization models needed for finding solutions to problems relating to production planning and scheduling, inventory, and warehouse design.

Evaluating The Student Training Equity Project: An Upstream Recruitment Approach To Diversifying Clinical Psychology Graduate Programs, Hannah L. Joseph, Mary Fernandes, Meghan Goyer, M. Alejandra Arce, Ciera Lewis, Claudia A. Delbasso, Suzann Lawry, Corey A. Walker, Omolade Amole, Mikael Sampson, Erin Tone

Georgia Educational Researcher

The U.S. psychology workforce is considerably less diverse than the population that it serves. While several recruitment and admission practices are effective for diversifying psychology training programs, upstream recruitment of underrepresented candidates is particularly promising. Aiming to diversify the clinical psychology graduate program applicant pool, the Student Training Equity Project (STEP) was developed to promote and evaluate upstream recruitment of undergraduate students of color interested in psychology graduate studies. This study used a mixed-method design to evaluate immediate outcomes for three STEP programmatic strategies. Survey results suggest that STEP networking events were associated with undergraduate research and mentorship opportunities. Findings …

Pas Hall Of Fame 2022 Bernard Woma, Robert Damm

CoE Publications

No abstract provided.

Machine Learning And Software Solutions For Data Quality Assessment In Cern’S Atlas Experiment, Cary Randazzo

Master's Theses

The Large Hadron Collider (LHC) is home to multiple particle physics experiments designed to verify the standard model and push our understanding of the universe to its limits. The ATLAS detector is one of the large general-purpose experiments that make use of the LHC and generates a significant amount of data as part of its regular operations. Prior to physics analysis, this data is cleaned through a data assessment process which involves significant operator resources. With the evolution of the field of machine learning and anomaly detection, there is great opportunity to upgrade the ATLAS Data Quality Monitoring Framework to …

Tumor Lysis Syndrome (Tls), Children's Mercy Kansas City

Clinical Pathways (Formally Known As Clinical Practice Guidelines)

No abstract provided.

Disability Inclusion, Quality Improvement Center For Workforce Development

Workforce Analytics Resources

The following resources provide information to help agencies create disability-inclusive workplace policies and practices. The Office of Disability Employment Policy (ODEP) is a non-regulatory federal agency that promotes policies and coordinates with employers and all levels of government to increase workplace success for people with disabilities. The Employer Assistance and Resource Network on Disability Inclusion (EARN) is an ODEP technical assistance center that provides resources to help employers recruit, hire, retain, and advance individuals with disabilities and comply with their responsibilities under the ADA. Inclusion@Work: A Framework for Building a Disability-Inclusive Organization allows organizations to explore strategies for creating disability-inclusive …

Leadership Practices In Urban High Schools That Decrease Dropout Rates, Karura Rainey York

Doctoral Dissertations

The purpose of this study was to investigate the practices urban school leaders implement in daily school operations, how they form relationships with their students, and how these practices and relationships affect student initiative to engage in the high school experience and earn a diploma. High school students living in urban communities are often challenged by academic and societal deficits that separate them from their suburban counterparts. Students in these circumstances are more apt to drop out of high school. Leadership practices executed by urban school leaders to connect with their students are instrumental in motivating students to persist toward …

Surgical Stabilization Versus Nonoperative Treatment For Flail And Non-Flail Rib Fracture Patterns In Patients With Traumatic Brain Injury, Jonne T.H. Prins, Esther M. M. Van Lieshout, Francis Ali-Osman, Zachary M. Bauman, Eva-Corina Caragounis, Jeff Choi, D. Benjamin Christie Iii, Peter A. Cole, William B. Devoe, Andrew R. Doben, Evert A. Eriksson, Joseph D. Forrester, Douglas R. Fraser, Brendan Gontarz, Claire Hardman, Daniel G. Hyatt, Adam J. Kaye, Huan-Jang Ko, Kiara N. Leasia, Stuart Leon, Silvana F. Marasco, Allison G. Mcnickle, Timothy Nowack, Temi D. Ogunleye, Prakash Priya, Aaron P. Richman, Victoria Schlanser, Gregory Semon, Ying-Hao Su, Michael H. J. Verhofstad, Julie Whitis, Fredric M. Pieracci, Mathieu M. E. Wijffels

Department of Surgery Faculty Publications

Purpose: Literature on outcomes after SSRF, stratified for rib fracture pattern is scarce in patients with moderate to severe traumatic brain injury (TBI; Glasgow Coma Scale ≤ 12). We hypothesized that SSRF is associated with improved outcomes as compared to nonoperative management without hampering neurological recovery in these patients.

Methods: A post hoc subgroup analysis of the multicenter, retrospective CWIS-TBI study was performed in patients with TBI and stratified by having sustained a non-flail fracture pattern or flail chest between January 1, 2012 and July 31, 2019. The primary outcome was mechanical ventilation-free days and secondary outcomes …

Effect Of Varying Amounts Of Sandstone On The Performance Of Asphalt Mixtures In Arkansas, David Murphy

Graduate Theses and Dissertations

There are many different species and subspecies of aggregate used across the state of Arkansas, and the rest the country. However, it cannot be presumed that the amount and type of these aggregates will be compatible with the commonly used asphalt binder of an area; this can lead to performance issues and premature pavement damage. It has been suspected in Arkansas that an excessive amount of sandstone in asphalt mixtures may be a culprit of some of these premature pavement damage issues, especially regarding the moisture susceptibility of a pavement. This study aimed to analyze the performance effects of using …

The Effect Of Plant Elicitor Peptide On Nematode Infected Soybean, Siyang Liu

Graduate Theses and Dissertations

Soybean (Glycine max), an important economic crop native to East Asia, is grown worldwide for its edible beans. Soybean plants are vulnerable to a wide range of diseases, and nematodes are among the worst pests of soybean. The southern root-knot nematode (Meloidogyne incognita) and soybean cyst nematode (Heterodera glycines) are both notable nematode pests of soybean, with the soybean cyst nematode causing more than 30% of total yield loss in the US. Numerous attempts have been made to control soybean nematodes over the past several decades, and genetic engineering technology has received a lot of attention in recent years. Plant …

Environmental Communication: Changing The Attitude-Behavioral Gap In Science Communication Utilizing Strategic Messaging, Carrie Helgeson Nelms

Graduate Theses and Dissertations

National Polls in the United States consistently find the public’s beliefs and attitudes about climate change and other environmental issues significantly diverge from those held by the science community. A communication gap between the findings on the causes and effects of environmental issues and the public’s inability to interpret or refuse to accept these findings are possible causes of this divergence. This communication gap constitutes a threat to society because of inaction to environmental problems and points to needed changes in scientific messaging that better informs and motivates behavioral change. The present research employed a strategic message design to affect …

Analysis Of Seismicity And Related Seismic Risk In Muslim Countries: Case Studies From Afghanistan And Pakistan, Ikramuddin Bahram

Graduate Theses and Dissertations

How communities respond to a natural hazard is influenced by how they perceive it. This dissertation evaluated the gap between intent and action regarding earthquake hazards in Muslim countries with a focus on Afghanistan and Pakistan. Cultural biases provided predictions of risk perceptions and risk-taking preferences that were often more powerful than measures of knowledge and experience. In Muslim communities, perception of risk was influenced by the teachings of Islam and related rituals, traditions, and culture.

This study evaluated the seismicity and earthquake hazard in Afghanistan and Pakistan. Assessments of seismic risk and perception of danger were conducted to examine …

Assessing Consumer Demand, Producer Profitability, And The Environmental Impacts Of Conservation Agriculture Adoption In Sub-Saharan Africa, Willy Byamungu Mulimbi

Graduate Theses and Dissertations

This dissertation explores three aspects of conservation agriculture (CA) in the Sub-Saharan African region (SSA). The first article examines the demand side of CA and explores whether urban maize (Zea mays L.) consumers in the Democratic Republic of the Congo (DRC) would be willing to pay a premium for CA-produced maize flour. The second article estimates the effects CA provides to adopters and their farms in smallholder farming systems in the DRC, focusing on changes in soil properties and cowpea (Vigna unguiculata) yields. The final article uses a Life Cycle Assessment (LCA) approach to monetize the environmental impacts of adopting …