Digital Commons Network^™

Metabolic Syndrome Predictors Of Brain Gray Matter Volume In An Age-Stratified Community Sample Of 776 Mexican- American Adults: Results From The Genetics Of Brain Structure Image Archive, Eithan Kotkowski, Larry R. Price, Ralph A. Defronzo, Crystal G. Franklin, Maximino Salazar, Amy S. Garrett, Mary Woolsey, John Blangero, Ravi Duggirala, David C. Glahn, Peter T. Fox

School of Medicine Publications

Introduction: This project aimed to investigate the association between biometric components of metabolic syndrome (MetS) with gray matter volume (GMV) obtained with magnetic resonance imaging (MRI) from a large cohort of community-based adults (n = 776) subdivided by age and sex and employing brain regions of interest defined previously as the “Neural Signature of MetS” (NS-MetS).

Methods: Lipid profiles, biometrics, and regional brain GMV were obtained from the Genetics of Brain Structure (GOBS) image archive. Participants underwent T1-weighted MR imaging. MetS components (waist circumference, fasting plasma glucose, triglycerides, HDL cholesterol, and blood pressure) were defined using the National Cholesterol …

Overlapping And Distinct Functions Of The Paralogous Pagr Regulators Of Bacillus Anthracis, Ileana D Corsi, Theresa M Koehler

Faculty, Staff and Student Publications

The Bacillus anthracis pagA gene, encoding the protective antigen component of anthrax toxin, is part of a bicistronic operon on pXO1 that codes for its own repressor, PagR1. In addition to the pagAR1 operon, PagR1 regulates sap and eag, two chromosome genes encoding components of the surface layer, a mounting structure for surface proteins involved in virulence. Genomic studies have revealed a PagR1 paralog, PagR2, encoded by a gene on pXO2. The amino acid sequences of the paralogues are 71% identical and show similarity to the ArsR family of transcription regulators. We determined that the expression of either rPagR1 …

Amino Acids, Microbiota-Related Metabolites, And The Risk Of Incident Diabetes Among Normoglycemic Chinese Adults: Findings From The 4c Study, Shuangyuan Wang, Mian Li, Hong Lin, Guixia Wang, Yu Xu, Chunyan Hu, Ruizhi Zheng, Ruying Hu, Lixin Shi, Rui Du, Qing Su, Jiqiu Wang, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Ruixin Liu, Xiaolin Wang, Qi Li, Guijun Qin, Qin Wan, Gang Chen, Min Xu, Meng Dai, Di Zhang, Xulei Tang, Zhengnan Gao, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Shenghan Lai, Yiming Mu, Lulu Chen, Donghui Li, Guowang Xu, Guang Ning, Weiqing Wang, Yufang Bi, Jieli Lu

Faculty, Staff and Student Publications

Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs and 22 MRMs in 3,414 subjects with incident diabetes and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic AAs, asparagine, alanine, glutamic acid, homoserine, 2-aminoadipic acid, histidine, methionine, and proline are positively associated with incident T2DM. In the MRM panel, serum carnitines, N-acetyltryptophan, and uric acid are positively associated with …

Effect Of Roflumilast Cream Vs Vehicle Cream On Chronic Plaque Psoriasis: The Dermis-1 And Dermis-2 Randomized Clinical Trials, Zoe D Draelos, Neal Bhatia, James Q Del Rosso, Laura K Ferris, Lawrence J Green, Adelaide A Hebert, Terry Jones, Steven E Kempers, David M Pariser, Paul S Yamauchi, Matthew Zirwas, Lorne Albrecht, Alim R Devani, Mark Lomaga, Amy Feng, Scott Snyder, Patrick Burnett, Robert C Higham, David R Berk

Faculty, Staff and Student Publications

IMPORTANCE: Once-daily roflumilast cream, 0.3%, a potent phosphodiesterase 4 inhibitor, demonstrated efficacy and was well tolerated in a phase 2b trial of patients with psoriasis.

OBJECTIVE: To evaluate the efficacy of roflumilast cream, 0.3%, applied once daily for 8 weeks in 2 trials of patients with plaque psoriasis.

DESIGN, SETTING, AND PARTICIPANTS: Two phase 3, randomized, double-blind, controlled, multicenter trials (DERMIS-1 [trial 1; n = 439] and DERMIS-2 [trial 2; n = 442]) were conducted at 40 centers (trial 1) and 39 centers (trial 2) in the US and Canada between December 9, 2019, and November 16, 2020, and between …

Intensity-Modulated Radiation Therapy Reduces Patient-Reported Chronic Toxicity Compared With Conventional Pelvic Radiation Therapy: Updated Results Of A Phase Iii Trial, Anamaria R Yeung, Snehal Deshmukh, Ann H Klopp, Karen M Gil, Lari Wenzel, Andre A Konski, William Small, J Spencer Thompson, Desiree E Doncals, Guilherme H C Cantuaria, David P D'Souza, Amy Chang, Vijayananda Kundapur, Dasarahally S Mohan, Michael L Haas, Yong Bae Kim, Catherine L Ferguson, Stephanie L Pugh, Lisa A Kachnic, Deborah W Bruner

Faculty, Staff and Student Publications

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned coprimary or secondary analyses are not yet available.

Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.

The purpose of this update was to determine differences in patient-reported chronic toxicity and disease outcomes with intensity-modulated radiation therapy (IMRT) compared with conventional pelvic radiation. Patients with cervical and endometrial cancers who received postoperative pelvic radiation …

Overlapping And Distinct Functions Of The Paralogous Pagr Regulators Of Bacillus Anthracis

Faculty, Staff and Student Publications

The Bacillus anthracis pagA gene, encoding the protective antigen component of anthrax toxin, is part of a bicistronic operon on pXO1 that codes for its own repressor, PagR1. In addition to the pagAR1 operon, PagR1 regulates sap and eag, two chromosome genes encoding components of the surface layer, a mounting structure for surface proteins involved in virulence. Genomic studies have revealed a PagR1 paralog, PagR2, encoded by a gene on pXO2. The amino acid sequences of the paralogues are 71% identical and show similarity to the ArsR family of transcription regulators. We determined that the expression of either rPagR1 …

A Novel Method For Identifying Coded Tags Recorded On Aquatic Acoustic Monitoring Systems, Christopher D. Lowe, Nicolas J.C. Tregenza, Claudia J. Allen, Georgina E. Blow, Hanna Nuuttila, Chiara M. Bertelli, Anouska F. Mendzil, Thomas Stamp, Emma V. Sheehan, Peter Davies, Jonathan C.D. Gordon, Jonathan D. Bolland, J. Robert Britton, Robert Main, Randolph Velterop, Charles Crundwell, Andrew Schofield, David R.K. Clarke

School of Biological and Marine Sciences

AbstractAquatic biotelemetry increasingly relies on using acoustic transmitters (‘tags’) that enable passive detection of tagged animals using fixed or mobile receivers. Both tracking methods are resource-limited, restricting the spatial area in which movements of highly mobile animals can be measured using proprietary detection systems. Transmissions from tags are recorded by underwater noise monitoring systems designed for other purposes, such as cetacean monitoring devices, which have been widely deployed in the marine environment; however, no tools currently exist to decode these detections, and thus valuable additional information on animal movements may be missed. Here, we describe simple hybrid methods, with potentially …

Sequential Lonsdaleite To Diamond Formation In Ureilite Meteorites Via In Situ Chemical Fluid/Vapor Deposition, Andrew G. Tomkins, Nicholas C. Wilson, Colin Macrae, Alan Salek, Matthew R. Field, Helen E.A. Brand, Andrew D. Langendam, Natasha R. Stephen, Aaron Torpy, Zsanett Pintér, Lauren A. Jennings, Dougal G. Mcculloch

School of Geography, Earth and Environmental Sciences

Ureilite meteorites are arguably our only large suite of samples from the mantle of a dwarf planet and typically contain greater abundances of diamond than any known rock. Some also contain lonsdaleite, which may be harder than diamond. Here, we use electron microscopy to map the relative distribution of coexisting lonsdaleite, diamond, and graphite in ureilites. These maps show that lonsdaleite tends to occur as polycrystalline grains, sometimes with distinctive fold morphologies, partially replaced by diamond + graphite in rims and cross-cutting veins. These observations provide strong evidence for how the carbon phases formed in ureilites, which, despite much conjecture …

Emergency Department Transfers From Residential Aged Care: What Can We Learn From Secondary Qualitative Analysis Of Australian Royal Commission Data?, Patricia Cain, Janine Alan, Davina Porock

Research outputs 2022 to 2026

Objectives: To use publicly available submissions and evidence from the Australian Royal Commission into Aged Care Quality and Safety as data for secondary qualitative analysis. By investigating the topic of emergency department transfer from the perspective of residents, family members and healthcare professionals, we aimed to identify modifiable factors to reduce transfer rates and improve quality of care. Design: The Australian Royal Commission into Aged Care Quality and Safety has made over 7000 documents publicly available. We used the documents as a large data corpus from which we extracted a data set specific to our topic using keywords. The analysis …

Clustering Behavior In Solar Flare Dynamics, Elmer C. Rivera, Jay R. Johnson, Jonathan Homan, Simon Wing

Faculty Publications

The solar magnetic activity cycle provides energy input that is released in intense bursts of radiation known as solar flares. As such, the dynamics of the activity cycle is embedded in the sequence of times between the flare events. Recent analysis shows that solar flares exhibit memory on different timescales. These previous studies showed that the time ordering of flare events is not random, but rather there is dependence between successive flares. In the present work, the clustering of flares is demonstrated through a straightforward nonparametric method where the cumulative distribution function of successive flares is compared with the cumulative …

The Roles Of Flux Tube Entropy And Effective Gravity In The Inward Plasma Transport At Saturn, S. Wing, M. F. Thomsen, J. R. Johnson, D. G. Mitchell, R. C. Allen, X. Ma, P. A. Delamere

Faculty Publications

The inward plasma transport at the Saturnian magnetosphere is examined using the flux tube interchange stability formalism developed by Southwood & Kivelson. Seven events are selected. Three cases are considered: (1) the injected flux tube and ambient plasmas are nonisotropic, (2) the injected flux tube and ambient plasmas are isotropic, and (3) the injected flux tube plasma is isotropic, but the ambient plasma is nonisotropic. Case 1 may be relevant for fresh injections, while case 3 may be relevant for old injections. For cases 1 and 2, all but one event have negative stability conditions, suggesting that the flux tube …

Current Understanding Of Osteoarthritis Pathogenesis And Relevant New Approaches, Liping Tong, Huan Yu, Xingyun Huang, Jie Shen, Guozhi Xiao, Lin Chen, Huaiyu Wang, Lianping Xing, Di Chen

2020-Current year OA Pubs

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during OA development. To better understand the pathological mechanisms of OA, new approaches, methods, and techniques need to be used to understand OA pathogenesis. In this review, we first focus on the epigenetic regulation of OA, with a particular focus on DNA methylation, histone modification, and microRNA regulation, followed by a summary of several key …

Neighborhood Characteristics And Dementia Symptomology Among Community-Dwelling Older Adults With Alzheimer’S Disease, Dana M. Alhasan, Matthew C. Lohman Ph.D., Jana A. Hirsch, Margaret Chandlee Miller Ms, Ph.D., Bo Cai Ph.D., Chandra L. Jackson

Faculty Publications

Background: Neuropsychiatric symptoms (NPSs) lead to myriad poor health outcomes among individuals with Alzheimer’s disease (AD). Prior studies have observed associations between the various aspects of the home environment and NPSs, but macro-level environmental stressors (e.g., neighborhood income) may also disrupt the neuronal microenvironment and exacerbate NPSs. Yet, to our knowledge, no studies have investigated the relationship between the neighborhood environment and NPSs.

Methods: Using 2010 data among older adults with AD collected from a sample of the South Carolina Alzheimer’s Disease Registry, we estimated cross-sectional associations between neighborhood characteristics and NPSs in the overall population and by race/ethnicity. Neighborhood …

Effect Of The Tokyo 2020 Summer Olympic Games On Covid-19 Incidence In Japan: A Synthetic Control Approach, Daisuke Yoneoka, Akifumi Eguchi, Kentato Fukumoto, Takayuki Kawashima, Yuta Tanoue, Takahiro Tabuchi, Hiroaki Miyata, Cyrus Ghaznavi, Kenji Shibuya, Shuhei Nomura

2020-Current year OA Pubs

BACKGROUND: The Tokyo 2020 Summer Olympic Games (23 July-8 August 2021) were held in the middle of Japan's fifth wave of COVID-19, when the number of cases was on the rise, and coincided with the fourth state of emergency implemented by the host city, Tokyo.

AIM: This study aimed to assess whether the hosting of the Games was associated with a change in the number of COVID-19 cases in Japan using a synthetic control method.

METHODS: A weighted average of control countries with a variety of predictors was used to estimate the counterfactual trajectory of daily COVID-19 cases per 1 …

Access To Nature And Economy In Rochester, Nh: Storymap Of A Walking Tour, Cody G. Crytzer, Shannon Rogers, Catherine M. Ashcraft

Faculty Publications

This StoryMap provides photos and short descriptions of a walking tour held on October 6, 2022 in Rochester, NH focused on exploring how access to nature supports a community’s economy and quality of life. The walking tour was organized by the Nature Economy Collaborative in partnership with the City of Rochester, Granite Outdoor Alliance, and the University of New Hampshire Cooperative Extension. Funding was provided by the University of New Hampshire Collaborative Research Excellence (CoRE) Initiative. The interactive StoryMap is available at: https://storymaps.arcgis.com/stories/9d7dc7cf7b0e4d349d082ac90b832d60/print

Single-Piece Burner_Id-06071, Christian Mohr

Defensive Publications Series

The present invention solving the above-mentioned problem provides a single-piece burner. The single-piece burner has an integrated piece portion including an orifice holder, a burner crown, and a gas injector, wherein the integrated piece portion is obtained by an aluminum die-casting process. The burner crown of the integrated piece portion has a through hole having two ends respectively connected to the injector of the integrated piece portion and a cap assembled to the single-piece burner. The internal shape of the through hole is defined as a divergent area from the one end connected to the injector of the integrated piece …

Session 3a: Karst And Groundwater, Kentucky Water Research Institute

Kentucky Water Resources Annual Symposium

• Examining the Utility of Tryptophan-Like Fluorescence As a Proxy for Fecal Contamination in Karst Basins, Inner Bluegrass Region, Kentucky
• A Predictive Flood Model for Urban Karst Environments
• Improving Best Management Practices for the Siting, Maintenance, and Design of Urban Karst Groundwater Injection Wells

Session 3b: Sediments, Kentucky Water Research Institute

Kentucky Water Resources Annual Symposium

• Sediment Degradation Experiments for a Low Gradient Stream Suggest the Watershed’s Connectivity Regime Exhibits Control on Stream Biogeochemistry
• Does Sediment Organic Matter Content Mediate the Effects of Chironomid Larvae on Benthic Nitrous Oxide Flux
• Drivers of Variability in Annual Sediment Accretion Rates Within Wetland Easements of Western Kentucky

Poster Session, Kentucky Water Research Institute

Kentucky Water Resources Annual Symposium

• Evaluating the Effects of Beaver Dam Removal on the Hydrology, Water Quality, and Bioindicators of a Restored Wetland
• Predictive Sediment Flux Modeling of a Karst Spring Using High Resolution Sensors and Stable Carbon and Nitrogen Isotopes
• Development and Validation of qPCR Assays for Use in eDNA Detection of Four Species of Semiaquatic Salamanders .
• Analyzing Recent Spatio-Temporal Rainfall Erosivity Patterns and Trends Across Kentucky
• Development of eDNA Protocols for Detection of Four Darter (Percidae: Etheostomatinae) Species in Central Kentucky Streams
• Assessing Change in the Seasonality of Stable Isotopes δ18O and δ2H for Meteoric and Terrestrial Waters of Central Kentucky
• Coupling …

Deaths In Open Water Swimming Races In Brazil From 2009 To 2019, Fabrízio Di Masi, Gabriel Costa E Silva, Danielli Braga De Mello, David Szpilman, Mike Tipton

International Journal of Exercise Science

International Journal of Exercise Science 15(6): 1295-1305, 2022. Since the inclusion in the Olympic Games (2008), open swimming races have attracted greater media attention and, therefore, have a greater number of practitioners, especially in Brazil, an extremely favorable country for this sport. However, increasing reports of fatal incidents in open water races brought the medical and scientific community to attention. The aim of this study was to review the characteristics of deaths in open waters events in Brazil from 2009 to 2019. The survey was divided into 3 steps: 1) contacting sports-related federations and companies, including swimming and triathlon federations, …

Session 2: Water And The Community, Kentucky Water Research Institute

Kentucky Water Resources Annual Symposium

• Development of Human Health Criteria for Surface Waters of the Commonwealth of Kentucky
• Kentucky Workforce Survey Results
• Modeling, Managing, and Mitigating Stormwater Flooding using a Real-time Monitoring Network and Environmental Equity Approach

“My Companion Through The Pandemic”: The Importance Of The Human-Animal Bond During Covid-19, Christine Krouzecky, Jan Aden, Anastasiya Bunina, Katharina Hametner, Armin Klaps, Zuzana Kovacovsky, Nora Ruck, Birgit Ursula Stetina

People and Animals: The International Journal of Research and Practice

The COVID- 19 pandemic, due to its global biopsychosocial effects, encourages re-search regarding the promotion of health. Studies in this area concentrate on the human–animal bond as a source of physical and psychological well- being (Shoesmith et al., 2021). In this context, contradictory results have been reported, which on the one hand underline the positive influences of animal companionship on humans’ well- being (Ratschen et al., 2020), and on the other hand demonstrate contrary effects (Mueller et al., 2021). Based on inconsistent findings, the present study aimed to investigate to what extent the human–animal bond influences different psychosocial parameters (including …

Mirrored Windows Theory And The Nypd: Does Heavy Surveillance Policing Translate Into Greater Use Of Force, Deborah A. Carroll

Journal of Public Management & Social Policy

No abstract provided.

“Why Do I Have To Send My Child There?” How Low-Income And Working-Class Black Mothers Perceive School Choice In Washington, D.C., Brian Robinson

Journal of Public Management & Social Policy

Despite being cemented into the American education system, school choice policies remain controversial among scholars, practitioners, policy makers, and education reform advocates. This study seeks to understand how low-income and working-class parents, for whom school choice advocates claim these policies are intended to benefit, perceive school choice and what motivates these perceptions. In particular, this study focuses on low-income and working-class Black mothers who are often disadvantaged in the education marketplace. Taking advantage of a relatively robust school choice system in Washington, D.C., the author interviewed 10 low-income and working-class Black mothers. The mothers in this sample see school choice …

State Tanf Spending: Does Devolution Matter?, Rhucha Samudra

Journal of Public Management & Social Policy

Using the state-level panel data, this study examines the role of Second-Order Devolution (SOD) in state TANF spending patterns. The study uses the Within-Between RE model to examine this connection. No statistically significant effect of second-order devolution is observed. The race continues to be a strong predictor of state funding and complex effects for Black, Hispanic, and Asian clients are observed. Such effects encourage a nuanced discussion of the racialization of welfare policy beyond the dichotomous exploration of black-white differences. Implications of this evidence are discussed.

Race And The Rush To Reopen Schools During Covid-19, Emily M. Farris, Heather Silber Mohamed

Journal of Public Management & Social Policy

While the emergence of the COVID-19 pandemic disrupted student learning in the spring of 2020 and impacted nearly all of the 55 million students in kindergarten to 12th grade nationwide, it also magnified significant racial inequities in schools and society. Generations of systemic racism left communities of color and their neighborhood schools more at risk during the crisis. Over the summer of 2020, school leaders and communities considered whether to reopen school campuses or keep buildings closed for the 2020-2021 academic school year, and media began to highlight racial and ethnic difference in attitudes about those plans. Consistent with popular …

Impact Of Stand Your Ground, Background Checks And Conceal And Carry Laws On Homicide Rates In The U.S, Sounak Chakraborty, Charles E. Menifield, Ranadeep Daw

Journal of Public Management & Social Policy

In recent years, the number of gun related killings appear to be on the rise. In fact, data show that gun related murders rose 32% between 2014 and 2017 (Gramlich 2019). While the second amendment to the U.S. Constitution allows citizens to bear weapons, many states have passed additional laws regulating the industry. These include restrictive and prohibitive laws. The goal of this paper is to assess the impact of changes in hand gun related legislation on firearm homicide rates in the United States for the period 1999-2015. More specifically, we focus on the impact of stand your ground, right …

Changing The Social Equity Language Game In Public Administration: An Ethical Perspective, Diana P. Negron, Parisa J. Vinzant, Staci M. Zavattaro, Adam M. Butz

Journal of Public Management & Social Policy

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Managed Racial Capitalism: Understanding The Bureaucratic State’S Racialized Practices In Detroit, Michigan, Meghan Wilson, Prentiss A. Dantzler, Jason D. Rivera

Journal of Public Management & Social Policy

Public administration navigates an important place in governing in that it is multidisciplinary and focused on practice, thus all theories need to be prepared to face critique from the people. At this watershed moment of social justice, political reckoning, and revolutionary imagination, it is key that public administration contends with the racist logics driving the field and the practice. In this article, we examine the ways that the current governing system fails to account for the racialized political economy, thus reproducing the inequality inherent in that system. The paper poses two questions: 1) How does the public administration of local …

Strategies For Introspection And Instruction Towards Antiracism In Public Management And Administration, Rachel Emas, Megan E. Hatch, Del Bharath, Tia Sherèe Gaynor

Journal of Public Management & Social Policy

To be anti-racist is to be actively engaged in the fight against racism, as inaction only serves to reinforce racism and oppression. In teaching the next generation of public servants, educators have a responsibility to be antiracist in their classrooms. The development of this antiracist approach requires both introspective and instructional efforts. Building on knowledge from Critical Race Theory, Black Feminism, intersectionality, and public service pedagogy, this article discusses the internal work that educators must undertake to become antiracist before teaching students how to do so. Then, the article explores what steps faculty can take towards building an antiracist pedagogy …