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Articles 672331 - 672360 of 5209315
Full-Text Articles in Entire DC Network
Think Tank Science And Engineering: Construction Of New High-End Think Tank Starts From Specialization And Scientifization To Disciplinization—Interview With Professor Pan Jiaofeng, Editorial Office Bulletin Of Chinese Academy Of Sciences
Think Tank Science And Engineering: Construction Of New High-End Think Tank Starts From Specialization And Scientifization To Disciplinization—Interview With Professor Pan Jiaofeng, Editorial Office Bulletin Of Chinese Academy Of Sciences
Bulletin of Chinese Academy of Sciences (Chinese Version)
No abstract provided.
2022 Issue 9 Content
Bulletin of Chinese Academy of Sciences (Chinese Version)
No abstract provided.
Ceballos V. Np Palace, Llc, 138 Nev. Adv. Op. 58 (August. 11, 2022), Lindsay Reynolds
Ceballos V. Np Palace, Llc, 138 Nev. Adv. Op. 58 (August. 11, 2022), Lindsay Reynolds
Nevada Supreme Court Summaries
NRS 613.333 creates a private right of action in favor of an employee discharged from employment for engaging in the lawful use in this state of any product outside the employer’s premises during the employee’s nonworking hours. Although marijuana is legal in Nevada, because federal law criminalizes marijuana in Nevada, its use is not “lawful . . . in this state” and, therefore, does not provide for a private right of action. Further, an employee discharged for testing positive for recreational marijuana at work does not have a common-law tortious discharge claim under NRS 678D.510(1)(a).
Rethinking Ethical Questions In Life-History Interview Research, Anne Rothe
Rethinking Ethical Questions In Life-History Interview Research, Anne Rothe
The Qualitative Report
Having interviewed Germans who emigrated to Israel and, in most cases, converted to Judaism, I experienced a paralyzing sense of ethical conflict when I began analyzing the first order discourse my participants and I had co-constructed to transform it into the second-order discourse of research publications. So, I set out to rethink the ethics of life-history interview research. My quest into our ethical responsibilities began with rule-based deontological and consequentialist ethics and the guidelines in the social sciences they inform. It led me to reconsider such core notions as informed consent, privacy, and risk-benefit analysis. I came to realize that …
Morton-Ordered Gpu Lattice Boltzmann Cfd Simulations With Application To Blood Flow, Gerald Gallagher, Fergal J. Boyle
Morton-Ordered Gpu Lattice Boltzmann Cfd Simulations With Application To Blood Flow, Gerald Gallagher, Fergal J. Boyle
Conference Papers
Computational fluid dynamics (CFD) is routinely used for numerically predicting cardiovascular-system medical device fluid flows. Most CFD simulations ignore the suspended cellular phases of blood due to computational constraints, which negatively affects simulation accuracy. A graphics processing unit (GPU) lattice Boltzmann-immersed boundary (LB-IB) CFD software package capable of accurately modelling blood flow is in development by the authors, focusing on the behaviour of plasma and stomatocyte, discocyte and echinocyte red blood cells during flow. Optimised memory ordering and layout schemes yield significant efficiency improvements for LB GPU simulations. In this work, comparisons of row-major-ordered Structure of Arrays (SoA) and Collected …
Tracking Health Behaviors In People With Multiple Sclerosis (Trac-Ms): Study Protocol And Description Of The Study Sample., Ruchika S Prakash, Heena R Manglani, Elizabeth J Duraney, Anita Shankar, Megan E Fisher, Alisha Janssen, Lauren Cea, Rick Petosa, Rebecca Andridge, Jacqueline Nicholas
Tracking Health Behaviors In People With Multiple Sclerosis (Trac-Ms): Study Protocol And Description Of The Study Sample., Ruchika S Prakash, Heena R Manglani, Elizabeth J Duraney, Anita Shankar, Megan E Fisher, Alisha Janssen, Lauren Cea, Rick Petosa, Rebecca Andridge, Jacqueline Nicholas
Ambulatory and Primary Care Articles
INTRODUCTION: People with multiple sclerosis (PwMS) experience a range of physical, cognitive, and affective symptoms. Behavioral interventions targeting increased physical activity show promising support as low-cost methods to improve working memory, episodic memory, and processing speed in PwMS. In this randomized controlled trial, we will examine the efficacy of a pedometer-tracking intervention, designed to increase low-to-moderate levels of physical activity, for improving working memory in PwMS.
METHODS AND ANALYSIS: Eighty-seven PwMS, between the ages of 30-59, have been recruited for the study. Seventy-five of the eligible and interested individuals were randomized to six-month health behavior monitoring groups: a Step-track group …
Can The Big Five Of Publishing Become The Big Four?, Olivia Nacionales
Can The Big Five Of Publishing Become The Big Four?, Olivia Nacionales
Cardozo Arts & Entertainment Law Journal (AELJ) Blog
On March 4, 2020, ViacomCBS announced its intention to sell its book-publishing subsidiary, Simon & Schuster. This announcement came less than a year after the merger between Viacom and CBS. Since the 2019 merger, ViacomCBS decided to focus on television and video and began selling its smaller companies that do not have a “significant connection for [its] broader business.” Prior to the announcement to buy Simon & Schuster, ViacomCBS had received “unsolicited inbound calls” regarding the sale of the book publishing company.
This post was originally published on the Cardozo Arts & Entertainment Law Journal website on September 20, 2022. …
Anticipating The New “Green Guides”: Ftc Promises Review Of Environmental Marketing Guidance, Frances Bandas
Anticipating The New “Green Guides”: Ftc Promises Review Of Environmental Marketing Guidance, Frances Bandas
Cardozo Arts & Entertainment Law Journal (AELJ) Blog
The Federal Trade Commission (“FTC”) is poised to review its “Green Guides,” a series of guidelines issued to help marketers make nondeceptive environmental claims that comply with federal regulations. Guidance is supplied for claims about a product or its packaging, claims made in connection with a sale or service, and all forms of marketing claims.
This post was originally published on the Cardozo Arts & Entertainment Law Journal website on September 20, 2022. The original post can be accessed via the Archived Link button above.
Whole-Tree Harvest Effects On Macronutrients In An Oak-Dominated System After Seven Years, Robert Richard, Evan Kane, Dustin Bronson, Randall Kolka
Whole-Tree Harvest Effects On Macronutrients In An Oak-Dominated System After Seven Years, Robert Richard, Evan Kane, Dustin Bronson, Randall Kolka
Michigan Tech Publications, Part 1
This study assesses the impacts of whole-tree harvesting (WTH) versus stem-only harvest (SOH) on two oak-dominated stands located in Northern Wisconsin. Specifically, our study follows up on an experiment designed to better understand the impacts of WTH and whether stands are at risk of long-term nutrient losses, which could contribute to declines in productivity. The original study assessed: (i) full biomass removal (referred to as WTH), (ii) partial biomass removal (removal to 5 cm diameter bole), (iii) a traditional SOH (removal to 10 cm bole), and (iv) no harvest (control). Our data were collected 93 months after harvest and showed …
Local Agency And Development Trajectories In A Rural Region, Deanna Hutchinson, Robyn Eversole
Local Agency And Development Trajectories In A Rural Region, Deanna Hutchinson, Robyn Eversole
Faculty Journal Articles
Employing a theoretical lens from the anthropology of development, this paper takes an actor-oriented approach to understand the socio-cultural context of regional path development in a peripheral rural region and the role of local agency, drawing on a qualitative case study of the Cradle Coast region of Tasmania, Australia. Findings demonstrate the value of bottom-up attention to the logics of regional actors to understand regional development trajectories and the emergence of new economic paths. Analysing the regional development logics and actions of local actors in particular contexts can reveal the mechanisms through which regions create new paths or reinforce old …
Invasive Group A Streptococcal Penicillin Binding Protein 2× Variants Associated With Reduced Susceptibility To Β-Lactam Antibiotics In The United States, 2015-2021, Theresa Tran, Yuan Li, Lesley Mcgee, Bernard Beall
Invasive Group A Streptococcal Penicillin Binding Protein 2× Variants Associated With Reduced Susceptibility To Β-Lactam Antibiotics In The United States, 2015-2021, Theresa Tran, Yuan Li, Lesley Mcgee, Bernard Beall
Faculty, Staff and Student Publications
All known group A streptococci [GAS] are susceptible to β-lactam antibiotics. We recently identified an invasive GAS (iGAS) variant (emm43.4/PBP2x-T553K) with unusually high minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin, although clinically susceptible to β-lactams. We aimed to quantitate PBP2x variants, small changes in β-lactam MICs, and lineages within contemporary population-based iGAS. PBP2x substitutions were comprehensively identified among 13,727 iGAS recovered during 2015-2021, in the USA. Isolates were subjected to antimicrobial susceptibility testing employing low range agar diffusion and PBP2x variants were subjected to phylogenetic analyses. Fifty-five variants were defined based upon substitutions within an assigned PBP2x …
College Of Business News, Georgia Southern University
College Of Business News, Georgia Southern University
College of Business: News & Publications
- Finance Alum Addresses FA and SIA Members
The George-Anne Daily, Georgia Southern University
The George-Anne Daily, Georgia Southern University
George-Anne Media Group: Newsletters & Magazines
No abstract provided.
A Reflection Of Canadian Society? An Analysis Of Federal Appointments To Provincial Superior Courts By The Liberal Government Of Justin Trudeau, Erin Crandall
Dalhousie Law Journal
Recent reforms to Canada’s system of federal judicial appointments have sought to make the process more transparent and better able to produce a bench reflective of the society it serves. This paper reviews these reforms and using judicial appointment data (2016–2020), considers whether the Liberal government has met these objectives. The relationship between official bilingualism and representation on the bench is also considered. The paper finds that “diversity” on Canada’s federally appointed provincial courts remains unbalanced. While women have made up the majority of appointments since the Trudeau Liberals formed government in 2015, other equity-deserving groups, like people of colour …
Impact Of Cardiac Disorders On Renal Function Tests And Serum Electrolytes In Sudanese Patients With Acute Myocardial Infarction, Abuagla M. Dafalla, Leena A. Dafalla
Impact Of Cardiac Disorders On Renal Function Tests And Serum Electrolytes In Sudanese Patients With Acute Myocardial Infarction, Abuagla M. Dafalla, Leena A. Dafalla
Muthanna Medical Journal
Acute myocardial infarction (AMI) is the most serious clinical manifestation of coronary artery disease leading to irreversible heart necrosis due to prolonged ischemia. From being an illness prevalent predominantly in developed countries, AMI is now becoming increasingly more common in developing countries. The study aims to estimate renal function test and serum electrolytes in acute myocardial infarction patients to reflect the effect of AMI on renal function. Case control study conducted at Cardiac center, Wad Medani, Gezira State, from September 2017 to February 2021. A total of three hundred and forty blood samples were collected, one hundred and seventy from …
Empowering Responsible And Sustainability-Aware Business Graduates Through Digital Authentic Assessment, Lucia Walsh, Olivia Freeman, Alacoque Mcalpine, Cormac H. Macmahon
Empowering Responsible And Sustainability-Aware Business Graduates Through Digital Authentic Assessment, Lucia Walsh, Olivia Freeman, Alacoque Mcalpine, Cormac H. Macmahon
Conference papers
Business schools must engage in fundamental change to retain their legitimacy and position themselves as providers of solutions to urgent economic, social and environmental crises. Achievement of the UN Sustainable Development Goals (SDGs) has emerged as a megatrend and business education must enhance graduate skills to contribute to their achievement. The world requires the next generation of graduates to become responsible business leaders who will address wicked sustainability problems. Hence, we need pedagogy that enables students to become sustainability literate and thus develop appropriate knowledge, skills and mindsets.
Authentic assessment provides transformative learning opportunities that empower students to achieve meaningful …
Comments For The Draft Final Butte Priority Soils Operable Unit, 2021 Unreclaimed Sites Sampling Ur-39 Site Evaluation Summary Report (June 15, 2022), Nikia Greene
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Distribution Of The Native Freshwater Mussels Anodonta Nuttalliana And Margaritifera Falcata In Utah And Western Wyoming Using Environmental Dna, Torrey W. Rodgers, Lusha M. Tronstad, Bernardo R. Gonzales, Madison Crawford, Karen E. Mock
Distribution Of The Native Freshwater Mussels Anodonta Nuttalliana And Margaritifera Falcata In Utah And Western Wyoming Using Environmental Dna, Torrey W. Rodgers, Lusha M. Tronstad, Bernardo R. Gonzales, Madison Crawford, Karen E. Mock
Western North American Naturalist
Native freshwater mussels have seen dramatic declines in western North America, but effective monitoring and management of these organisms can be difficult due to their cryptic nature. We used environmental DNA sampling—a sensitive, noninvasive genetic technique—to examine the contemporary distribution of 2 native freshwater mussel species, Anodonta nuttalliana and Margaritifera falcata, in Utah and western Wyoming. We sampled water bodies with historical presence, as well as additional water bodies and locations with promising habitat for the species. We detected A. nuttalliana from 39% of the 31 water bodies sampled and M. falcata from 16% of the 25 water …
Gata Now!, Georgia Southern University
Gata Now!, Georgia Southern University
Athletics: News & Publications
- Homecoming 2022
- Armstrong Shuttle Bus
- Back to the 2000's
- Single Game Tickets
- Pick 3 Mini Plans on Sale Now
- Pledge Now Per Win
- 2022 Football Schedule
- Tailgate
- Volleyball Schedule
- Women's Soccer Schedule
- Men's Soccer Schedule
- Full Schedule
- Headlines
Gata Now!, Georgia Southern University
Gata Now!, Georgia Southern University
Athletics: News & Publications
- Homecoming 2022
- Armstrong Shuttle Bus
- Back to the 2000's
- Single Game Tickets
- Pick 3 Mini Plans on Sale Now
- Pledge Now Per Win
- 2022 Football Schedule
- Tailgate
- Volleyball Schedule
- Women's Soccer Schedule
- Men's Soccer Schedule
- Full Schedule
- Headlines
Deja Vu: Semantics-Aware Recording And Replay Of High-Speed Eye Tracking And Interaction Data To Support Cognitive Studies Of Software Engineering Tasks—Methodology And Analyses, Vlas Zyrianov, Cole S. Peterson, Drew T. Guarnera, Joshua Behler, Praxis Weston, Bonita Sharif Ph.D., Jonathan I. Maletic
Deja Vu: Semantics-Aware Recording And Replay Of High-Speed Eye Tracking And Interaction Data To Support Cognitive Studies Of Software Engineering Tasks—Methodology And Analyses, Vlas Zyrianov, Cole S. Peterson, Drew T. Guarnera, Joshua Behler, Praxis Weston, Bonita Sharif Ph.D., Jonathan I. Maletic
School of Computing: Faculty Publications
The paper introduces a fundamental technological problem with collecting high-speed eye tracking data while studying software engineering tasks in an integrated development environment. The use of eye trackers is quickly becoming an important means to study software developers and how they comprehend source code and locate bugs. High quality eye trackers can record upwards of 120 to 300 gaze points per second. However, it is not always possible to map each of these points to a line and column position in a source code file (in the presence of scrolling and file switching) in real time at data rates over …
Development And Pretesting Of Prescription Opioid Misuse Prevention Messages: Results And Implications For Practice, Holli H. Seitz, Mary Nelson Robertson, Je'kylynn Steen, Sarah G. Dulaney, David R. Buys
Development And Pretesting Of Prescription Opioid Misuse Prevention Messages: Results And Implications For Practice, Holli H. Seitz, Mary Nelson Robertson, Je'kylynn Steen, Sarah G. Dulaney, David R. Buys
Publications
Well-designed health communication campaigns can contribute to the uptake of preventive behaviors, but there has been a lack of attention on using communication research to develop opioid misuse prevention messages. We report the results of two studies designed to inform the development of prescription opioid misuse prevention messages for adults ages 30–59. In Study 1, 16 adults across 4 counties participated in semi-structured interviews to provide input on message concepts addressing six key prescription opioid misuse prevention behaviors. In Study 2, 1,335 adults completed an online, survey-based between-subjects experiment in which participants were randomized to a no message control condition …
A Rare Cause Of Recurrent Hypersomnia- Klein-Levin Syndrome, Mohammed Khalid, Tariq Karim Dr, Waqas Anwar Dr
A Rare Cause Of Recurrent Hypersomnia- Klein-Levin Syndrome, Mohammed Khalid, Tariq Karim Dr, Waqas Anwar Dr
Manipal Journal of Medical Sciences
Recurrent episodes of severe hypersomnia coupled with cognitive and behavioral abnormalities like disorientation, apathy, derealization, compulsive eating and hypersexuality are hallmarks of unusual sleep disease known as Klein-Levin syndrome. We hereby discuss a 46-year-old gentleman who came with recurrent episode of loss of muscle tone, was diagnosed with Klein-Levin syndrome and responded well to medications.
Student Motivations And Barriers Toward Online And In-Person Office Hours In Stem Courses, Jeremy L. Hsu, Melissa Rowland-Goldsmith, Elaine Benaksas Schwartz
Student Motivations And Barriers Toward Online And In-Person Office Hours In Stem Courses, Jeremy L. Hsu, Melissa Rowland-Goldsmith, Elaine Benaksas Schwartz
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Office hours are one of the most common support mechanisms found in courses. Despite the prevalence of office hours in life sciences classes, there has been little investigation of how science, technology, engineering, and math (STEM) students perceive office hours, particularly at non–research intensive universities or other institutions where a majority of students attend office hours. We surveyed more than 500 students, representing most life sciences majors at a comprehensive university, to investigate their motivations and barriers for attending office hours. We then compared instructors’ perceptions to students’ conceptions of office hours. We identified key themes in student and instructor …
5 Things To Know About Open Enrollment, Linda Gunter
5 Things To Know About Open Enrollment, Linda Gunter
Browse All News
No abstract provided.
Kinetic Modeling Of Ionospheric Outflows Observed By The Visions-1 Sounding Rocket, Robert M. Albarran Ii
Kinetic Modeling Of Ionospheric Outflows Observed By The Visions-1 Sounding Rocket, Robert M. Albarran Ii
Doctoral Dissertations and Master's Theses
Plasma escape from the high-latitude ionosphere (ion outflow) serves as a significant source of heavy plasma to magnetospheric plasma sheet and ring current regions. Outflows alter mass density and reconnection rates, hence global responses of the magnetosphere. The VISIONS-1 (VISualizing Ion Outflow via Neutral atom imaging during a Substorm) sounding rocket was launched on Feb. 7, 2013 at 8:21 UTC from Poker Flat, Alaska, into an auroral substorm with the objective of identifying the drivers and dynamics of nightside ion outflow at altitudes where it is initiated, below 1000 km. Energetic ion data from the VISIONS-1 polar cap boundary crossing …
Metabolic Syndrome Predictors Of Brain Gray Matter Volume In An Age-Stratified Community Sample Of 776 Mexican- American Adults: Results From The Genetics Of Brain Structure Image Archive, Eithan Kotkowski, Larry R. Price, Ralph A. Defronzo, Crystal G. Franklin, Maximino Salazar, Amy S. Garrett, Mary Woolsey, John Blangero, Ravi Duggirala, David C. Glahn, Peter T. Fox
Metabolic Syndrome Predictors Of Brain Gray Matter Volume In An Age-Stratified Community Sample Of 776 Mexican- American Adults: Results From The Genetics Of Brain Structure Image Archive, Eithan Kotkowski, Larry R. Price, Ralph A. Defronzo, Crystal G. Franklin, Maximino Salazar, Amy S. Garrett, Mary Woolsey, John Blangero, Ravi Duggirala, David C. Glahn, Peter T. Fox
School of Medicine Publications
Introduction: This project aimed to investigate the association between biometric components of metabolic syndrome (MetS) with gray matter volume (GMV) obtained with magnetic resonance imaging (MRI) from a large cohort of community-based adults (n = 776) subdivided by age and sex and employing brain regions of interest defined previously as the “Neural Signature of MetS” (NS-MetS).
Methods: Lipid profiles, biometrics, and regional brain GMV were obtained from the Genetics of Brain Structure (GOBS) image archive. Participants underwent T1-weighted MR imaging. MetS components (waist circumference, fasting plasma glucose, triglycerides, HDL cholesterol, and blood pressure) were defined using the National Cholesterol …
Overlapping And Distinct Functions Of The Paralogous Pagr Regulators Of Bacillus Anthracis, Ileana D Corsi, Theresa M Koehler
Overlapping And Distinct Functions Of The Paralogous Pagr Regulators Of Bacillus Anthracis, Ileana D Corsi, Theresa M Koehler
Faculty, Staff and Student Publications
The Bacillus anthracis pagA gene, encoding the protective antigen component of anthrax toxin, is part of a bicistronic operon on pXO1 that codes for its own repressor, PagR1. In addition to the pagAR1 operon, PagR1 regulates sap and eag, two chromosome genes encoding components of the surface layer, a mounting structure for surface proteins involved in virulence. Genomic studies have revealed a PagR1 paralog, PagR2, encoded by a gene on pXO2. The amino acid sequences of the paralogues are 71% identical and show similarity to the ArsR family of transcription regulators. We determined that the expression of either rPagR1 …
Amino Acids, Microbiota-Related Metabolites, And The Risk Of Incident Diabetes Among Normoglycemic Chinese Adults: Findings From The 4c Study, Shuangyuan Wang, Mian Li, Hong Lin, Guixia Wang, Yu Xu, Chunyan Hu, Ruizhi Zheng, Ruying Hu, Lixin Shi, Rui Du, Qing Su, Jiqiu Wang, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Ruixin Liu, Xiaolin Wang, Qi Li, Guijun Qin, Qin Wan, Gang Chen, Min Xu, Meng Dai, Di Zhang, Xulei Tang, Zhengnan Gao, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Shenghan Lai, Yiming Mu, Lulu Chen, Donghui Li, Guowang Xu, Guang Ning, Weiqing Wang, Yufang Bi, Jieli Lu
Amino Acids, Microbiota-Related Metabolites, And The Risk Of Incident Diabetes Among Normoglycemic Chinese Adults: Findings From The 4c Study, Shuangyuan Wang, Mian Li, Hong Lin, Guixia Wang, Yu Xu, Chunyan Hu, Ruizhi Zheng, Ruying Hu, Lixin Shi, Rui Du, Qing Su, Jiqiu Wang, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Ruixin Liu, Xiaolin Wang, Qi Li, Guijun Qin, Qin Wan, Gang Chen, Min Xu, Meng Dai, Di Zhang, Xulei Tang, Zhengnan Gao, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Shenghan Lai, Yiming Mu, Lulu Chen, Donghui Li, Guowang Xu, Guang Ning, Weiqing Wang, Yufang Bi, Jieli Lu
Faculty, Staff and Student Publications
Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs and 22 MRMs in 3,414 subjects with incident diabetes and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic AAs, asparagine, alanine, glutamic acid, homoserine, 2-aminoadipic acid, histidine, methionine, and proline are positively associated with incident T2DM. In the MRM panel, serum carnitines, N-acetyltryptophan, and uric acid are positively associated with …
Effect Of Roflumilast Cream Vs Vehicle Cream On Chronic Plaque Psoriasis: The Dermis-1 And Dermis-2 Randomized Clinical Trials, Zoe D Draelos, Neal Bhatia, James Q Del Rosso, Laura K Ferris, Lawrence J Green, Adelaide A Hebert, Terry Jones, Steven E Kempers, David M Pariser, Paul S Yamauchi, Matthew Zirwas, Lorne Albrecht, Alim R Devani, Mark Lomaga, Amy Feng, Scott Snyder, Patrick Burnett, Robert C Higham, David R Berk
Effect Of Roflumilast Cream Vs Vehicle Cream On Chronic Plaque Psoriasis: The Dermis-1 And Dermis-2 Randomized Clinical Trials, Zoe D Draelos, Neal Bhatia, James Q Del Rosso, Laura K Ferris, Lawrence J Green, Adelaide A Hebert, Terry Jones, Steven E Kempers, David M Pariser, Paul S Yamauchi, Matthew Zirwas, Lorne Albrecht, Alim R Devani, Mark Lomaga, Amy Feng, Scott Snyder, Patrick Burnett, Robert C Higham, David R Berk
Faculty, Staff and Student Publications
IMPORTANCE: Once-daily roflumilast cream, 0.3%, a potent phosphodiesterase 4 inhibitor, demonstrated efficacy and was well tolerated in a phase 2b trial of patients with psoriasis.
OBJECTIVE: To evaluate the efficacy of roflumilast cream, 0.3%, applied once daily for 8 weeks in 2 trials of patients with plaque psoriasis.
DESIGN, SETTING, AND PARTICIPANTS: Two phase 3, randomized, double-blind, controlled, multicenter trials (DERMIS-1 [trial 1; n = 439] and DERMIS-2 [trial 2; n = 442]) were conducted at 40 centers (trial 1) and 39 centers (trial 2) in the US and Canada between December 9, 2019, and November 16, 2020, and between …