Digital Commons Network^™

Confirming Subarachnoid Hemorrhage Induction In The Endovascular Puncture Mouse Model, Ari Dienel, Sung-Ha Hong, Jose Guzman, Kumar T Peeyush, Spiros L Blackburn, Devin W Mcbride

Faculty, Staff and Student Publications

Background and purpose: Experimental studies of subarachnoid hemorrhage (SAH) using the endovascular perforation model routinely use either cerebral blood flow (CBF) or intracranial pressure (ICP) monitoring to confirm SAH induction. We designed this study to test the hypothesis that contralateral CBF is a better marker of SAH induction than ipsilateral CBF.

Methods: Sixty-eight adult C57BL/6J mice were subjected to endovascular perforation. Mice were monitored using laser Doppler (for relative CBF) or ICP probes.

Results: The ipsilateral CBF significantly decreased prior to ICP rising. However, reduction of the CBF in the contralateral hemisphere occurred at the same time as the rise …

Idh1 Prr32h Ctdna And D-2-Hydroxyglutarate As Csf Biomarkers In Patients With Idh-Mutant Gliomas, Yoko Fujita, Luis Nunez-Rubiano, Antonio Dono, Allison Bellman, Mauli Shah, Juan C Rodriguez, Vasanta Putluri, Abu Hena Mostafa Kamal, Nagireddy Putluri, Roy F Riascos, Jay-Jiguang Zhu, Yoshua Esquenazi, Leomar Y Ballester

Faculty, Staff and Student Publications

INTRODUCTION: We aimed to evaluate IDH1 p.R132H mutation and 2-hydroxyglutarate (2HG) in cerebrospinal fluid (CSF) as biomarkers for patients with IDH-mutant gliomas.

METHODS: CSF was collected from patients with infiltrating glioma, and 2HG levels were measured by liquid chromatography-mass spectrometry. IDH1 p.R132H mutant allele frequency (MAF) in CSF-ctDNA was measured by digital droplet PCR (ddPCR). Tumor volume was measured from standard-of-care magnetic resonance images.

RESULTS: The study included 48 patients, 6 with IDH-mutant and 42 with IDH-wildtype gliomas, and 57 samples, 9 from the patients with IDH-mutant and 48 from the patients with IDH-wildtype gliomas. ctDNA was detected in 7 …

Plasmonic Gadolinium Oxide Nanomatryoshkas: Bifunctional Magnetic Resonance Imaging Enhancers For Photothermal Cancer Therapy, Luke Henderson, Oara Neumann, Yara Kadria-Vili, Burak Gerislioglu, James Bankson, Peter Nordlander, Naomi J Halas

Faculty, Staff and Student Publications

Nanoparticle-assisted laser-induced photothermal therapy (PTT) is a promising method for cancer treatment; yet, visualization of nanoparticle uptake and photothermal response remain a critical challenge. Here, we report a magnetic resonance imaging-active nanomatryoshka (Gd2O3-NM), a multilayered (Au core/Gd2O3 shell/Au shell) sub-100 nm nanoparticle capable of combining T1 MRI contrast with PTT. This bifunctional nanoparticle demonstrates an r1 of 1.28 × 108 mM-1 s-1, an MRI contrast enhancement per nanoparticle sufficient for T1 imaging in addition to tumor ablation. Gd2O3-NM also shows excellent stability in an acidic environment, retaining 99% of the internal Gd(3). This report details the synthesis and characterization of …

Automation Of Radiation Treatment Planning For Rectal Cancer, Kai Huang, Prajnan Das, Adenike M Olanrewaju, Carlos Cardenas, David Fuentes, Lifei Zhang, Donald Hancock, Hannah Simonds, Dong Joo Rhee, Sam Beddar, Tina M Briere, Laurence Court

Faculty, Staff and Student Publications

PURPOSE: To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy (3DCRT) treatment planning that combines deep learning (DL) aperture predictions and forward-planning algorithms.

METHODS: We designed an algorithm to automate the clinical workflow for 3DCRT planning with field aperture creations and field-in-field (FIF) planning. DL models (DeepLabV3+ architecture) were trained, validated, and tested on 555 patients to automatically generate aperture shapes for primary (posterior-anterior [PA] and opposed laterals) and boost fields. Network inputs were digitally reconstructed radiographs, gross tumor volume (GTV), and nodal GTV. A physician scored each aperture for 20 patients on a 5-point scale (>3 …

Introduction To Mathematical Analysis I - 3rd Edition, Beatriz Lafferriere, Gerardo Lafferriere, Mau Nam Nguyen

PDXOpen: Open Educational Resources

Video lectures explaining problem solving strategies are available.

This set of lecture notes is meant to provide students with a strong foundation in mathematical analysis. Such a foundation is crucial for future study of deeper topics of analysis. Students should be familiar with most of the concepts presented here after completing the calculus sequence. However, these concepts will be reinforced through rigorous proofs.

Introduction to Mathematical Analysis II contains lecture notes that complement this book, with sections on integration, numerical series, series of functions, and selected advanced topics. Together, both volumes support a one semester or two-quarter course on introductory …

Crafting Strategy For Irregular Warfare: A Framework For Analysis And Action (2nd Edition), David H. Ucko, Thomas A. Marks

Strategic Monographs

The United States, and the West, struggle to understand and respond to irregular warfare, whether by states or nonstate actors. Attempts to master the art have generated much new jargon, ranging from “hybrid war” to “the gray zone,” and most recently “integrated deterrence.” The terminology belies a struggle to overcome entrenched presumptions about war—a confusion that generates cognitive friction with implications for strategy. To inform a better approach, this monograph presents an analytical framework to assess and respond to irregular threats.

Modelling Of Cohesive Expandable Lcms For Fractures With Large Apertures, Lu Lee, Musaab Magzoub, Arash Dahi Taleghani, Saeed Salehi, Guoqiang Li

Faculty Publications

The problem of loss circulation in geothermal wells is inherently challenging due to high temperatures, brittle rocks, and presence of abundant fractures. Because of the inherent challenges in geothermal environments, there are limitations in selecting proper lost circulation materials (LCMs). Traditional LCMs such as calcium carbonates that are commonly used in the oil and gas drilling may be softened and prone to failure during geothermal drilling. Moreover, evaluating the performance of different LCMs for geothermal drilling requires unique testing setups, which is expensive, and complicated to run due to harsh environmental conditions of geothermal systems. Herein, we present a numerical …

Thermal, Physical, And Optical Properties Of The Solution And Melt Synthesized Single Crystal Cspbbr3 Halide Perovskite, Kirti Agrawal, Syed Mohammad Abid Hasan, Joanna Blawat, Nishir Mehta, Yuming Wang, Rafael Cueto, Miriam Siebenbuerger, Orhan Kizilkaya, Narasimha S. Prasad, James Dorman, Rongying Jin, Manas Ranjan Gartia

Faculty Publications

Inorganic lead-halide perovskite, cesium lead bromide (CsPbBr3), shows outstanding optoelectronic properties. Both solution- and melt-based methods have been proposed for CsPbBr3 crystal growth. The solution-based growth was done at low-temperature, whereas the melt-based growth was done at high-temperature. However, the comparison of optical, physical, and defect states using these two different growth conditions has been scarcely studied. Here, we have compared the thermal and optical properties of solution-grown and melt-grown single crystals of CsPbBr3. Positron Annihilation Lifetime Spectroscopy (PALS) analysis showed that melt-grown crystal has a relatively smaller number of defects than the chemical synthesis method. In addition, crystals grown …

Multi-Objective Optimization Of Aquifer Storage And Recovery Operations Under Uncertainty Via Machine Learning Surrogates, Hamid Vahdat-Aboueshagh, Frank T.C. Tsai, Emad Habib, T. Prabhakar Clement

Faculty Publications

Aquifer storage and recovery (ASR) is an important water management approach to store excess surface water into aquifers for later use. Quantitative evaluation of ASR performance is not a trivial task and yet becomes more exacting when uncertainty analysis is added to the dimensionality of the problem. Inclusion of uncertainty into the framework of scheduling optimal ASR operations also increases the level of complexity. This study integrates a surrogate modeling approach coupled with a mixed integer nonlinear programming (MINLP) algorithm to optimize multi-objective ASR operations. The uncertainties are analyzed based upon a thorough sampling of the parameters space as well …

Bar Exam Registration Fees, Accesslex Institute

Law Licensing Process

This source includes data on bar exam registration fees, character and fitness investigation fees, law student registration fees, late registration penalties, and laptop fees for the 50 states and the District of Columbia.

September 2022 Library News, University Libraries

Library News

No abstract provided.

Gulf Coast Faculty Council Minutes - September 01, 2022, Usm Gulf Coast Faculty Council

Gulf Coast Faculty Council Minutes

No abstract provided.

2022-September-01-Graduate Program In Geosciences Earns National Recognition, University Marketing And Communication, East Tennessee State University

ETSU News

East Tennessee State University’s Geosciences Department, known for offering students valuable field experience and professors excelling in both research and teaching, has added a national recognition. 

The master’s degree in geosciences, geospatial analysis concentration, received an honorable mention for the 2022 American Association of Geographers Award for Master's Program Excellence. 

“This is a wonderful honor for ETSU,” said Dr. Ingrid Luffman, an associate professor who helped prepare the award application. “This concentration was established in 2011 and is already helping fill a rapidly growing industry.”  

Geosciences offers potential graduate students an option to concentrate in either geospatial analysis …

Volume 106, Number 3 (2023)

Judicature

No abstract provided.

Taxing Risky Development: A New Tool For Increasing Coastal Resilience, James Daher

Michigan Journal of Environmental & Administrative Law

Coastal overdevelopment in the United States is a persistent issue. Climate change continues to increase the risk of flooding and other damage from natural disasters facing many coastal communities. Yet, development in some of the most at-risk areas has not slowed. Policies at the federal government level have encouraged such development by shifting costs of flood-related property damage from the property owner to taxpayers. At the same time, government actors at all levels are actively trying to protect their coastlines through coastal resilience projects. However, there are not enough funds to protect coastal property, especially at the state and local …

Generalization Of Bi-Canonical Degrees, Joseph Brennan, Laura Ghezzi, Jooyoun Hong, Wolmer Vasconcelos

Publications and Research

We discuss invariants of Cohen-Macaulay local rings that admit a canonical module ω. Attached to each such ring R, when ω is an ideal, there are integers–the type of R, the reduction number of ω–that provide valuable metrics to express the deviation of R from being a Gorenstein ring. In (Ghezzi et al. in JMS 589:506–528, 2017) and (Ghezzi et al. in JMS 571:55–74, 2021) we enlarged this list with the canonical degree and the bi-canonical degree. In this work we extend the bi-canonical degree to rings where ω is not necessarily an ideal. We also discuss generalizations to rings …

Issue Brief: Impact Assessment And Responsible Business Guidance Tools In The Extractive Sector: An Environmental Human Rights Toolbox For Government, Business, Civil Society & Indigenous Groups, Sara L. Seck, Penelope Simmons, Charlotte Connolly

Responsible Business Conduct and Impact Assessment Law

This issue brief provides an overview of the impact assessment and responsible business conduct toolbox for the extractive sector. The toolbox provides guidance on how governments, businesses, civil society, and Indigenous groups may encourage and adopt a human rights approach to impact assessment (IA). It forms part of a broader research project aimed at highlighting the interrelationship between IA laws and Responsible Business Conduct (RBC) tools, funded by the Social Sciences & Humanities Research Council (SSHRC) Knowledge Synthesis Grant: Informing Best Practices in Environmental & Impact Assessments (the “KSG”).

Is It Time To Bury Barry? Why An Old Change At The Legislature Requires A New Look At Washington's Nondelegation Doctrine, Daniel A. Himebaugh

Washington Law Review Online

Fifty years ago, the Supreme Court of Washington adopted a relaxed version of the nondelegation doctrine in a case called Barry and Barry v. Department of Motor Vehicles. The Barry rule, which only loosely restricts the delegation of policy-making power from the Legislature to other bodies, is now widely applied in Washington State. However, the Barry Court’s reasons for adjusting the nondelegation doctrine were based on an outdated understanding of the Legislature, especially its regular session schedule. While the Legislature’s regular sessions have changed since 1972—becoming longer and more frequent due to constitutional amendment—the Court has not considered how …

Pestfacts Wa Issue 15 - September 2022, Svetlana Micic, Cindy L. Webster, Jean Galloway, Mark Seymour, Kithsiri Jayasena, Andrea Hills, Ciara Beard

PestFacts WA

PestFacts WA Issue 15 - September 2022 contents:

• Managing diamondback moths late in the season
• Chocolate spot in faba beans
• Loose smut in barley

Lsab Minutes September 2022, Shawna Battle, Maryke H. Barber

WRL: Library Student Advisory Board Minutes

No abstract provided.

Mckee Minute September 2022, Southern Adventist University

McKee Minute – McKee Library This Month

The September 2022 issue of McKee Minute includes information on Hispanic Heritage Month, Living Memoirs, Statista, and new books.

Ipulse: September 2022, Lynn University

Student Newspapers

Issues:

• September 2022 [Fall Week 1]: Meet the iPulse Staff
• September 2022 [Fall Week 2]: Healthy Habits for a Healthier You; How to Stress Less; This Isn't Your Grandma's Library!; Is Music a Study Aid?; Food Stop: BagelWorks; From Placekicker to Social Media Superstar; Believe and Achieve; Going Out With a Bang; Remembering Oregon Ducks Football Player Spencer Webb

Clinical Efficacy Of Ultrasound Guided Erector Spinae Plane Block In Patients Undergoing Microwave Ablation, Özlem Öz Gergin, Sibel Seçkin Pehlivan, İbrahim Erkan, Adnan Bayram, Recep Aksu, Cihangir Biçer, Karamehmet Yıldız, Güven Kahriman

Saudi Medical Journal

Objectives: To compare the effect of pre-emptive erector spinae plane block (ESPB) applied before the procedure on opioid consumption during the procedure and analgesic demand and opioid consumption after the procedure. Methods: American Society of Anesthesiologists Physical Status Classification (ASA) I-II, 30 patients, with liver tumor and planned for microwave ablation (MWA) treatment were included in the interventional radiology clinic, Erciyes University, Kayseri, Turkey, Turkey between 2021 and 2022. Patients were randomized either to the ESPB or control group. Ultrasound-guided ESPB block with 20 mL of 0.25% bupivacaine was performed preoperatively in the ESPB group patients, and the patients who …

The Importance Of Emphasizing Addiction Medicine During Medical Toxicology Fellowship Training: A Case Study Of Tertiary Care Hospital System Toxicology Consultation Service, Nicholas S. Imperato, Chase Jones Do, Derek J. Fikse Do, Gillian A. Beauchamp Md, Marna R. Greenberg Do, Mph, Facep, Alexandra Amaducci, Katelyn Mclain

Toxicology Division

No abstract provided.

On Behalf Of The Toxicology Investigators Consortium (Toxic). A Five-Year Analysis Of The Toxicology Investigator’S Consortium (Toxic) Core Registry: Exposure Differences In Patients That Identified As Transgender Vs. Cisgender, K Magnusson, Derek J. Fikse Do, E Glidden, Gillian A. Beauchamp Md, K Aldy, D Mustaquim, Judith Sabino Mph, Cdp, Marna R. Greenberg Do, Mph, Facep, Alexandra Amaducci

Toxicology Division

No abstract provided.

Forensic Investigation Of Google Meet For Memory And Browser Artifacts, Farkhund Iqbal, Zainab Khalid, Andrew Marrington, Babar Shah, Patrick C.K. Hung

All Works

Web applications have experienced a widespread adaptation owing to the agile Service Oriented Architecture (SOA) reflecting the ever-changing software needs of users. Google Meet is one of the top video conferencing applications, especially in the post-COVID19 era. Security and privacy concerns are therefore critical. This paper presents an extensive digital forensic analysis of Google Meet running on multiple browsers and software platforms including Google Chrome, Mozilla Firefox, and Microsoft Edge browsers in Windows 10 and Linux. Artifacts, traces of potential evidence, are extracted from different locations on a client's desktop, including the memory and browser. These include meeting records, communication …

Genetic Structure Correlates With Ethnolinguistic Diversity In Eastern And Southern Africa, Elizabeth G. Atkinson, Shareefa Dalvie, Yakov Pichkar, Allan Kalungi, Lerato Majara, Anne Stevenson, Tamrat Abebe, Dickens Akena, Melkam Alemayehu, Lukoye Atwoli

Brain and Mind Institute

African populations are the most diverse in the world yet are sorely underrepresented in medical genetics research. Here, we examine the structure of African populations using genetic and comprehensive multi-generational ethnolinguistic data from the Neuropsychiatric Genetics of African Populations-Psychosis study (NeuroGAP-Psychosis) consisting of 900 individuals from Ethiopia, Kenya, South Africa, and Uganda. We find that self-reported language classifications meaningfully tag underlying genetic variation that would be missed with consideration of geography alone, highlighting the importance of culture in shaping genetic diversity. Leveraging our uniquely rich multi-generational ethnolinguistic metadata, we track language transmission through the pedigree, observing the disappearance of several …

Post-Digital Curation: The Contemporary Flaneur, Technology And The Artist Book, Jared O’Sullivan

Postgraduate

This project identifies and examines the emergent themes in the original photographic work of Australian photographer Jared O’Sullivan from 2009 – 2019 and reflects on the curation and production of a retrospective artist book that celebrates a decade of professional practice.

The exegesis explores how the creation of an artist book retrospective can illuminate underlying themes in past works and how curation as method facilitates the discovery and communication of these new insights into practice. Referencing the works of Charles Baudelaire, Walter Benjamin and Susan Sontag, the literature review explores the effects of technology in relation to photographic theory and …

Law Library Blog (September 2022): Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.

Leukapheresis Guidance And Best Practices For Optimal Chimeric Antigen Receptor T-Cell Manufacturing., Muna Qayed, Joseph P. Mcguirk, Douglas Myers, Vinod Parameswaran, Edmund K. Waller, Peter Holman, Margarida Rodrigues, Lee F. Clough, Jennifer Willert

Manuscripts, Articles, Book Chapters and Other Papers

Chimeric antigen receptor (CAR) T-cell therapy is an individualized immunotherapy that genetically reprograms a patient's T cells to target and eliminate cancer cells. Tisagenlecleucel is a US Food and Drug Administration-approved CD19-directed CAR T-cell therapy for patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia and r/r diffuse large B-cell lymphoma. Manufacturing CAR T cells is an intricate process that begins with leukapheresis to obtain T cells from the patient's peripheral blood. An optimal leukapheresis product is essential to the success of CAR T-cell therapy; therefore, understanding factors that may affect the quality or T-cell content is imperative. CAR T-cell therapy …