Digital Commons Network^™

Screening Families In Primary Care For Social And Economic Needs: Patients’ Urgency And Activation For Social Care Navigation, Sarah D. Ronis, Marie Masotya, Kurt C. Stange

Faculty Scholarship

Introduction: Social determinants of health (SDoH) screening and intervention in primary care aim to alleviate adverse influences on health, but its efficacy may be diluted when offered supports are not well matched to families’ desire for such services. The purpose of this prospective cohort study was to provide guidance to social care navigation teams regarding which families would be most likely to make use of services. Methods: Analysis of registry data collected in April 1–September 30, 2021 from a social care navigation program embedded in a medical home was conducted. Multivariable regression models explored (1) whether family-reported urgency of needs, …

Tct-70 Clinical Predictors Of Patients Requiring Prolonged Mechanical Circulatory Support After High-Risk Pci, Mir B. Basir, Alejandro Lemor, Yanru Li, Bjorn Redfors, Alexander Truesdell, Aditya Bharadwaj, Amir Kaki, David Wohns, Perwaiz Meraj, Ramesh Daggubati, Cindy Grines, William O'Neill, Jeffrey Moses

Cardiology Meeting Abstracts

Background: There are limited data on predicative parameters to guide weaning after high-risk percutaneous coronary intervention (HRPCI) requiring mechanical circulatory support (MCS).

Methods: Patients enrolled into the prospective, multicenter, adjudicated, PROTECT III study who underwent HRPCI with Impella MCS were evaluated. Patients who required prolonged MCS, defined as requiring ongoing MCS beyond the index PCI, were compared to those in whom MCS was successfully weaned and explanted after index PCI.

Results: 1,196 patients were treated at 46 sites between 2017 and 2020. 207 patients (17%) required prolonged support with a mean duration of support of 27.3 ± 34.2 compared to …

Impact Of Covid-19 Pandemic On Tavr Activity: A Worldwide Registry, Xavier Armario, Jennifer Carron, Mohamed Abdel-Wahab, Didier Tchetche, Sabine Bleiziffer, Thierry Lefevre, Thomas Modine, Alexander Wolf, Thomas Pilgrim, Pedro Villablanca, Michael Cunnington, Nicolas Van Mieghem, Christian Hengstenberg, Lars Sondergaard, Martin Swaans, Bernard Prendergast, Marco Barbanti, John Webb, Neal Uren, Jon Resar, Mao Chen, David Hildick-Smith, Mark Spence, David Zweiker, Rodrigo Bagur, Hospital De Cruz, Flavio Ribichini, Duk-Woo Park, Pablo Codner, Joanna Wykrzykowska, Matjaz Bunc, Rodrigo Estevez-Loureiro, Karl Poon, Matthias Götberg, Hüseyin Ince, Azeem Latib, Erik Packer, Marco Angelillis, Yusuke Kobari, Luis Nombela-Franco, Yingqiang Guo, Mikko Savontaus, Amr A. Arafat, Chad Kliger, David Roy, Béla Merkely, Mariana Silva, Jonathon White, Masanori Yamamoto, Pedro Carrilho Ferreira, Stefan Toggweiler, Yohei Ohno, Ines Rodrigues, Soledad Ojeda, Vasileios Voudris, Marek Grygier, Khaled Almerri, Ignacio Cruz-Gonzalez, Viliam Fridrich, Jose De La Torre Hernandez, Nicolo Piazza, Stephane Noble, Dabit Arzamendi, Ibrahim H. Kurt, Johan Bosmans, Martins Erglis, Ivan Casserly, Fadi Sawaya, Ravinay Bhindi, Joelle Kefer, Wei-Hsian Yin, Liesbeth Rosseel, Hyo-Soo Kim, Stephen O'Connor, Farrel Hellig, Matias Sztejfman, Oscar Mendiz, Robert Xuereb, Fabio Brito Jr, Vilhelmas Bajoras, Mohammed Balghith, Michael Kang-Yin Lee, Guering Eid-Lidt, Bert Vandeloo, Vinicius Vaz, Mirvat Alasnag, Gian Paolo Ussia, Jorge Mayol, Gennaro Sardella, Wacin Buddhari, Hsien-Li Kao, Antonio Dager, Apostolos Tzikas, Ahmad Edris, Luis Gutierrez, Eduardo Arias, Mehmet Erturk, César Nicolás Conde Vela, Darko Boljevic, Adolfo Ferrero Guadagnoli, Ahmed Elguindy, Luciano Santos, Luis Perez, Gabriel Maluenda, Ali Riza Akyüz, Imad Alhaddad, Haitham Amin, So Chak Yu, Arif Alnooryani, Juan Albistur, Quang Nguyen, Darren Mylotte

Cardiology Meeting Abstracts

Background: The COVID-19 pandemic had a considerable impact on the provision of structural heart intervention worldwide. Our objectives were: 1) to assess the impact of the COVID-19 pandemic on transcatheter aortic valve replacement (TAVR) activity globally; and 2) to determine the differences in the impact according to geographic region and the demographic, development, and economic status of diverse international health care systems.

Methods: We developed a multinational registry of global TAVR activity and invited individual TAVR sites to submit TAVR implant data before and during the COVID-19 pandemic. Specifically, the number of TAVR procedures performed monthly from January 2019 to …

Tct-374 Structural Heart Intraprocedural Versus Nonprocedural Transesophageal Echocardiography: A Quantitative Analysis Of Complexity, Ayman Alsaadi, Ali H. Ghandour, Abel Ignatius, Alexandra Martin, James Lee, Bobak T. Rabbani, Bryan Zweig, Sachin Parikh, Pedro Villablanca, Carl P. Wilson, Tiberio Frisoli, Brian P. O'Neill, William O'Neill, Dee Dee Wang

Cardiology Meeting Abstracts

Background: Transesophageal echocardiography (TEE) is an essential tool in many structural heart procedures, such as transcatheter mitral valve edge-to-edge repair (TEER). Interventional procedural TEE requires a unique skill set. This study aims to evaluate the complexity of interventional structural heart TEE used to guide TEER compared with standard of care (SOC) TEE studies performed at a single center.

Methods: A retrospective case-control analysis was performed of 200 patients who underwent TEE in the Henry Ford Health System. One hundred cases of interventional TEE-guided TEER were compared with 100 controls of SOC TEE. Complexity was quantified by the total duration of …

Tct-353 Clinical Characteristics And Outcomes Of Alcohol Septal Ablation In The Era Of Transcatheter Valve Interventions, Samuel Gregerson, Shazil Mahmood, Collin Brooks, Pedro Engel Gonzalez, Pedro Villablanca, Tiberio Frisoli, James Lee, Dee Dee Wang, William O'Neill, Brian P. O'Neill

Cardiology Meeting Abstracts

Background: Alcohol septal ablation (ASA) is an alternative to surgical myectomy for left ventricular outflow tract (LVOT) obstruction in HCM and pre-emptive before transcatheter mitral valve replacement (TMVR) to prevent LVOT obstruction. This study aimed to evaluate the procedural characteristics and outcomes of ASA in contemporary practice.

Methods: This was a single-center retrospective study of 137 patients undergoing ASA for HCM and TMVR at Henry Ford Hospital from January 2010 to August 2021. Patient/procedure characteristics and outcomes were assessed. The primary endpoint was an adverse composite of new pacemaker requirement (PPM), stroke, sustained ventricular tachycardia, resuscitated cardiac arrest, and all-cause …

Tct-66 Door To Impella Placement In Acute Coronary Syndrome Complicated By Cardiogenic Shock: An Updated Meta-Analysis, Mario Iannaccone, Luca Franchin, Ivan Hanson, Giacomo Boccuzzi, Mir B. Basir, Alexander Truesdell, William O'Neill

Cardiology Meeting Abstracts

Background: The impact of time to hemodynamic support in acute myocardial infarction complicated by cardiogenic shock (AMICS) has yet to be defined. The aim of this meta-analysis was to evaluate the impact of timing of mechanical circulatory support (MCS) with Impella.

Methods: a systematic literature review and meta-analysis was conducted using PubMed and Cochrane databases. All studies reporting short-term mortality rates and timing of Impella insertion, pre vs during/post PCI, were included. Primary end point was short-term mortality (≤30 days), while secondary end pointswere midterm mortality, device-related bleeding and limb ischemia.

Results: Of 1,289 studies identified, 13 studies (6,810 patients; …

Tct-171 Predicting The Risk Of Perforation Requiring Pericardiocentesis In Chronic Total Occlusion Percutaneous Coronary Intervention: The Progress-Cto Pericardiocentesis Score, Bahadir Simsek, Spyridon Kostantinis, Judit Karacsonyi, Khaldoon Alaswad, Oleg Krestyaninov, Dmitrii Khelimskii, Rhian Davies, Jeremy Rier, Omer Goktekin, Sevket Gorgulu, Ahmed Elguindy, Raj Chandwaney, Mitul Patel, Dimitri Karmpaliotis, Jaikirshan Khatri, Farouc Jaffer, Paul Poommipanit, Bavana Rangan, Yader Sandoval, Basem Elbarouni, William Nicholson, Stephane Rinfret, Michail Koutouzis, Ioannis Tsiafoutis, Robert Yeh, M. Nicholas Burke, Salman Allana, Olga Mastrodemos, Emmanouil Brilakis

Cardiology Meeting Abstracts

Background: Estimating the risk for complications facilitates risk-benefit assessment and procedural planning in chronic total occlusion (CTO) percutaneous coronary intervention (PCI).

Methods: We analyzed the PROGRESS-CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention; NCT02061436) and created a risk score for pericardiocentesis. Patients with histories of coronary artery bypass graft surgery were excluded. Logistic regression prediction modeling was used to identify independently associated variables, and the model was internally validated with bootstrapping.

Results: Of the 7,672 CTO PCI cases performed between 2012 and 2022 at 40 centers, 83 (1.1%) required pericardiocentesis. The final prediction model identified predictors …

Tct-113 Predicting The Risk Of In-Hospital Major Adverse Cardiovascular Events In Chronic Total Occlusion Percutaneous Coronary Intervention: The Progress-Cto Mace Score, Bahadir Simsek, Spyridon Kostantinis, Judit Karacsonyi, Khaldoon Alaswad, Oleg Krestyaninov, Dmitrii Khelimskii, Rhian Davies, Jeremy Rier, Omer Goktekin, Sevket Gorgulu, Ahmed Elguindy, Raj Chandwaney, Mitul Patel, Dimitri Karmpaliotis, Jaikirshan Khatri, Farouc Jaffer, Paul Poommipanit, Bavana Rangan, Yader Sandoval, Basem Elbarouni, William Nicholson, Stephane Rinfret, Michail Koutouzis, Ioannis Tsiafoutis, Robert Yeh, M. Nicholas Burke, Salman Allana, Emmanouil Brilakis

Cardiology Meeting Abstracts

Background: Estimating the risk of complications in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) facilitates risk-benefit assessment and procedural planning.

Methods: We analyzed the Prospective Global Registry for the Study of Chronic Total Occlusion Intervention (PROGRESS-CTO; NCT02061436) and created a risk score for in-hospital major adverse cardiovascular events (MACE). Logistic regression prediction modeling was used to identify independently associated variables and the model was internally validated with bootstrapping.

Results: Of the 10,480 CTO PCI cases performed between 2012-2022 at 40 US and non-US centers, in-hospital MACE occurred in 215 (2.05%). The final prediction model identified 5 independent predictors of …

Tct-123 Predictors Of Success In Primary Retrograde Strategy In Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From The Progress-Cto Registry, Bahadir Simsek, Spyridon Kostantinis, Judit Karacsonyi, Khaldoon Alaswad, Dimitri Karmpaliotis, Farouc Jaffer, Jaikirshan Khatri, Paul Poommipanit, Sevket Gorgulu, Omer Goktekin, Oleg Krestyaninov, Rhian Davies, Ahmed Elguindy, Elias Haddad, Jimmy Kerrigan, Mitul Patel, Raj Chandwaney, Olga Mastrodemos, Salman Allana, Bavana Rangan, Emmanouil Brilakis

Cardiology Meeting Abstracts

Background: An upfront (primary) retrograde strategy is often used in chronic total occlusion (CTO) percutaneous coronary intervention (PCI).

Methods: We examined the clinical, angiographic characteristics, and procedural outcomes of CTO PCIs that were approached with a primary retrograde strategy in the Prospective Global Registry for the Study of CTO Intervention (PROGRESS-CTO; NCT02061436). Interventional collaterals were defined as collaterals that appeared suitable for retrograde CTO PCI.

Results: Of 10,286 CTO PCIs, a primary retrograde strategy was used in 1,329 (13%) with an initial technical success of 66% and a final success of 83% with subsequent strategies. Successful vs unsuccessful primary retrograde …

Tct-117 Impact Of Proximal Cap Ambiguity On The Outcomes Of Chronic Total Occlusion Intervention: Insights From The Progress-Cto Registry, Spyridon Kostantinis, Bahadir Simsek, Judit Karacsonyi, Khaldoon Alaswad, Michael Megaly, Oleg Krestyaninov, Dmitrii Khelimskii, Farouc Jaffer, Jaikirshan Khatri, Paul Poommipanit, Mitul Patel, Ehtisham Mahmud, Michail Koutouzis, Ioannis Tsiafoutis, Sevket Gorgulu, Basem Elbarouni, William Nicholson, Wissam Jaber, Stephane Rinfret, Omer Goktekin, Ahmed Elguindy, Yader Sandoval, M. Nicholas Burke, Salman Allana, Bavana Rangan, Emmanouil Brilakis

Cardiology Meeting Abstracts

Background: The impact of proximal cap ambiguity on procedural techniques and outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has received limited study.

Methods: We examined the clinical and angiographic characteristics and procedural outcomes of 11,169 CTO PCIs performed in 10,932 patients at 42 US and non-US centers between 2012 and 2022.

Results: Proximal cap ambiguity was present in 35% of CTO lesions. Patients whose lesions had proximal cap ambiguity were more likely to have had prior PCI (65% vs 59%; P < 0.01) and prior coronary artery bypass graft surgery (37% vs 24%; P < 0.01). Lesions with proximal cap ambiguity were more complex with higher J-CTO score (3.1 ± 1.0 vs 2.0 ± 1.2; P < 0.01) and lower technical (79% vs 90%; P < 0.01) and procedural success (77% vs 89%; P < 0.01) rates compared with non-ambiguous CTO lesions. The incidence of major adverse cardiovascular events (MACE) was higher in cases with proximal cap ambiguity (2.5% vs 1.7%; P < 0.01). The retrograde approach was more commonly used among cases with ambiguous proximal cap (51% vs 21%; P < 0.01) and was more likely to be the final successful crossing strategy (29% vs 13%; P < 0.01). PCIs of CTOs with ambiguous proximal cap required longer procedure time (140 [95-195] vs 105 [70-150] min; P < 0.01) and more contrast volume (225 [160-305] vs 200 [150-280] mL; P < 0.01).

Conclusion: Proximal cap ambiguity in CTO lesions is associated with higher utilization of the retrograde approach, …

Tct-128 Saphenous Vein Graft Occlusion Following Native Vessel Chronic Total Occlusion Percutaneous Coronary Intervention, Spyridon Kostantinis, Bahadir Simsek, Judit Karacsonyi, Khaldoon Alaswad, Michael Megaly, Farouc Jaffer, Jaikirshan Khatri, Paul Poommipanit, Rhian Davies, Stephane Rinfret, Basem Elbarouni, Luiz Ybarra, Abdul Sheikh, Catalin Toma, Raj Chandwaney, Omer Goktekin, Ahmed Elguindy, Olga Mastrodemos, Bavana Rangan, M. Nicholas Burke, Emmanouil Brilakis

Cardiology Meeting Abstracts

Background: The practice of occluding patent saphenous vein grafts (SVGs) after successful chronic total occlusion (CTO) percutaneous coronary intervention (PCI) of the native vessel has received limited study.

Methods: We analyzed baseline clinical and angiographic characteristics and procedural outcomes of 51 patients who following successful CTO PCI of the native vessel underwent attempted SVG occlusion between 2015 and 2022 at 14 centers. Results: Mean patient age was 71 ± 8 years and 80% were men. The most common CTO target vessel was the right coronary artery (41%), followed by the left circumflex artery (35%). Retrograde crossing was the successful crossing …

Tct-170 Development And Validation Of A Scoring System For Predicting Clinical Coronary Artery Perforation During Percutaneous Coronary Interventions Of Chronic Total Occlusions: The Progress-Cto Perforation Score, Spyridon Kostantinis, Bahadir Simsek, Judit Karacsonyi, Khaldoon Alaswad, Farouc Jaffer, Jaikirshan Khatri, James Choi, Wissam Jaber, Stephane Rinfret, William Nicholson, Mitul Patel, Ehtisham Mahmud, Catalin Toma, Rhian Davies, Jimmy Kerrigan, Elias Haddad, Sevket Gorgulu, Ahmed Elguindy, Omer Goktekin, Salman Allana, M. Nicholas Burke, Olga Mastrodemos, Bavana Rangan, Emmanouil Brilakis

Cardiology Meeting Abstracts

Background: Coronary artery perforation is a feared complication of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) and often leads to serious adverse clinical events.

Methods: We analyzed clinical and angiographic parameters from 9,618 CTO PCIs in the PROGRESS-CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention). Logistic regression prediction modeling was used to identify independently associated variables, and models were internally validated with bootstrapping. Clinical coronary artery perforation was defined as any perforation requiring treatment.

Results: The incidence of clinical coronary perforation was 3.8% (n = 367). Five factors were independently associated with perforation and were …

Invasive Versus Conservative Strategy In Elderly Patients With Non–St-Segment Elevation Myocardial Infarction: A Meta-Analysis Of Randomized Controlled Trials, Mahmoud Khalil, Muhammad H. Maqsood, Mir B. Basir, Marwan Saad, George Yassa, Laila Hakam, Bassam Hennawy, Shehad El Etriby, Santiago Garcia, Emmanouil Brilakis, Khaldoon Alaswad, Michael Megaly

Cardiology Meeting Abstracts

Background: Management of non–ST-segment elevation myocardial infarction (NSTEMI) has evolved over the years, but most published data are from younger patients. Data on the NSTEMI management in elderly patients remains limited. Methods: We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the long-term outcomes of invasive vs conservative strategies in elderly patients with NSTEMI.

Results: Of 1,550 reports searched, 4 RCTs (1,126 patients) were included in the analysis with a median follow-up of 1.25 years (range: 1 to 2.5 years). The median age of included patients was 83.6 (IQR 2.8 years). The invasive strategy was associated with significantly …

Tct-109 Use Of Subintimal Tracking And Reentry Technique In Chronic Total Occlusion Percutaneous Coronary Intervention, Judit Karacsonyi, Spyridon Kostantinis, Bahadir Simsek, Khaldoon Alaswad, Dimitri Karmpaliotis, Ajay Kirtane, Margaret Mcentegart, Farouc Jaffer, James Choi, Paul Poommipanit, Michalis Koutouzis, Ioannis Tsiafoutis, Jaikirshan Khatri, David Kandzari, Ray Chandwaney, Basem Elbarouni, Sevket Gorgulu, Ahmed Elguindy, Nidal Abi-Rafeh, Omer Goktekin, Imre Ungi, Bavana Rangan, Olga Mastrodemos, Yader Sandoval, Salman Allana, M. Nicholas Burke, Emmanouil Brilakis

Cardiology Meeting Abstracts

Background: There are limited data on the use of the subintimal tracking and reentry (STAR) technique for chronic total occlusion (CTO) percutaneous coronary intervention (PCI).

Methods: We analyzed 2,353 CTO PCIs performed using antegrade dissection re-entry (ADR) in the PROGRESS-CTO Registry, between 2012 and June 2022 at 41 centers.

Results: STAR was used in 450 cases (19.1%), primary STAR in 325 (13.8%) and secondary STAR (STAR after other ADR approaches) in 125 (5.3%). The Stingray system was used in 1,048 (44.5%), limited antegrade subintimal tracking (LAST) in 177 (7.5%), and contrast-guided STAR in 31 (1.3%) of re-entry cases. The mean …

How Many Mutex Bugs Can A Simple Analysis Find In Go Programs?, Fumi Takeuchi, Hidehiko Masuhara, Raffi Khatchadourian, Youyou Cong, Keisuke Ishibashi

Publications and Research

In open-source software, it is known that there are many concurrency bugs. A previous study in Go revealed that a considerable number of such bugs are simple (for example, 9% of the bugs are the ones that forget to unlock a mutex,) through a manual program investigation. This paper tries to detect such bugs by applying a simple analysis to see how far such a tool can match the manual analysis. We built a simple intraprocedural control flow analysis in Go, and evaluated its performance concerning the open source programs with concurrency bugs reported in the previous study. Consequently, as …

Processing And Mechanical Properties Of Hot-Pressed Zirconium Diboride – Zirconium Carbide Ceramics, Eric W. Neuman, William Fahrenholtz, Gregory E. Hilmas

Materials Science and Engineering Faculty Research & Creative Works

ZrB2 was mixed with 0.5 wt% carbon and up to 10 vol% ZrC and densified by hot-pressing at 2000 °C. All compositions were > 99.8% dense following hot-pressing. The dense ceramics contained 1–1.5 vol% less ZrC than the nominal ZrC addition and had between 0.5 and 1 vol% residual carbon. Grain sizes for the ZrB2 phase decreased from 10.1 µm for 2.5 vol% ZrC to 4.2 µm for 10 vol% ZrC, while the ZrC cluster size increased from 1.3 µm to 2.2 µm over the same composition range. Elastic modulus was ~505 GPa and toughness was ~2.6 MPa·m½ for all compositions. …

Global Tellurium Supply Potential From Electrolytic Copper Refining, Nedal T. Nassar, Haeyeon Kim, Max Frenzel, Michael S. Moats, Sarah M. Hayes

Materials Science and Engineering Faculty Research & Creative Works

The transition towards renewable energy requires increasing quantities of nonfuel mineral commodities, including tellurium used in certain photovoltaics. While demand for tellurium may increase markedly, the potential to increase tellurium supply is not well-understood. In this analysis, we estimate the quantity of tellurium contained in anode slimes generated by electrolytic copper refining by country between 1986 and 2018, including uncertainties. For 2018, the results indicate that 1930 (1500-2700, 95% confidence interval) metric tons of tellurium were contained in anode slimes globally. This is nearly quadruple the reported tellurium production for that year. China has the greatest potential to increase tellurium …

Best Practices For Reducing Construction Accidents Involving Hispanic Construction Workers, Michael E. Asuquo, Khalid Siddiqi

The Professional Constructor

The objective of this study was to determine best practices for reducing accidents among Hispanic construction workers. It was hypothesized that language barrier between the Hispanics and American workers contributed immensely to high rate of construction accidents on industrial projects. Accident case studies and questionnaire survey were both used. Data was collected through semi-structured interviews with Hispanic workers involved in industrial construction projects in Metro Atlanta. Findings from the study concluded that most accidents involving Hispanic workers were caused due to lack of communication from supervisors, ignorance of workers on work procedures, lack of equipment training, and worker negligence. Language …

Construction Management Internship: A Key Opportunity For Assessment And Continuous Curriculum Improvement, James S. Vaux, Bree Dority, Dana E. Vaux

The Professional Constructor

The internship is an integral part of most Construction Management curricula. Studies have noted the importance and reciprocal value of internships for the student, the employer, and the academic program. However, to date, no studies have specifically outlined the value internships provide to the CM program for assessment and evaluation. This paper examines the value of the CM internship as an indirect measure to assess and incorporate change into program curricula. With 10 years of qualitative and quantitative data collected from CM student interns, industry employers, and university internship supervisors, this study supports that CM internships are a valuable tool …

Genetic Loci And Prioritization Of Genes For Kidney Function Decline Derived From A Meta-Analysis Of 62 Longitudinal Genome-Wide Association Studies, Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F Thomas, Sarah E Graham, Gardar Sveinbjornsson, Thomas W Winkler, Felix Günther, Klaus J Stark, Jin-Fang Chai, Bamidele O Tayo, Matthias Wuttke, Yong Li, Adrienne Tin, Tarunveer S Ahluwalia, Johan Ärnlöv, Bjørn Olav Åsvold, Stephan J L Bakker, Bernhard Banas, Nisha Bansal, Mary L Biggs, Ginevra Biino, Michael Böhnke, Eric Boerwinkle, Erwin P Bottinger, Hermann Brenner, Ben Brumpton, Robert J Carroll, Layal Chaker, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Audrey Y Chu, Marina Ciullo, Massimiliano Cocca, James P Cook, Josef Coresh, Daniele Cusi, Martin H De Borst, Frauke Degenhardt, Kai-Uwe Eckardt, Karlhans Endlich, Michele K Evans, Mary F Feitosa, Andre Franke, Sandra Freitag-Wolf, Christian Fuchsberger, Piyush Gampawar, Ron T Gansevoort, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Christian Gieger, Daniel F Gudbjartsson, Stein Hallan, Pavel Hamet, Asahi Hishida, Kevin Ho, Edith Hofer, Bernd Holleczek, Hilma Holm, Anselm Hoppmann, Katrin Horn, Nina Hutri-Kähönen, Kristian Hveem, Shih-Jen Hwang, M Arfan Ikram, Navya Shilpa Josyula, Bettina Jung, Mika Kähönen, Irma Karabegović, Chiea-Chuen Khor, Wolfgang Koenig, Holly Kramer, Bernhard K Krämer, Brigitte Kühnel, Johanna Kuusisto, Markku Laakso, Leslie A Lange, Terho Lehtimäki, Man Li, Wolfgang Lieb, Lifelines Cohort Study, Lars Lind, Cecilia M Lindgren, Ruth J F Loos, Mary Ann Lukas, Leo-Pekka Lyytikäinen, Anubha Mahajan, Pamela R Matias-Garcia, Christa Meisinger, Thomas Meitinger, Olle Melander, Yuri Milaneschi, Pashupati P Mishra, Nina Mononen, Andrew P Morris, Josyf C Mychaleckyj, Girish N Nadkarni, Mariko Naito, Masahiro Nakatochi, Mike A Nalls, Matthias Nauck, Kjell Nikus, Boting Ning, Ilja M Nolte, Teresa Nutile, Michelle L O'Donoghue, Jeffrey O'Connell, Isleifur Olafsson, Marju Orho-Melander, Afshin Parsa, Sarah A Pendergrass, Brenda W J H Penninx, Mario Pirastu, Michael H Preuss, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Myriam Rheinberger, Kenneth M Rice, Federica Rizzi, Alexander R Rosenkranz, Peter Rossing, Jerome I Rotter, Daniela Ruggiero, Kathleen A Ryan, Charumathi Sabanayagam, Erika Salvi, Helena Schmidt, Reinhold Schmidt, Markus Scholz, Ben Schöttker, Christina-Alexandra Schulz, Sanaz Sedaghat, Christian M Shaffer, Karsten B Sieber, Xueling Sim, Mario Sims, Harold Snieder, Kira J Stanzick, Unnur Thorsteinsdottir, Hannah Stocker, Konstantin Strauch, Heather M Stringham, Patrick Sulem, Silke Szymczak, Kent D Taylor, Chris H L Thio, Johanne Tremblay, Simona Vaccargiu, Pim Van Der Harst, Peter J Van Der Most, Niek Verweij, Uwe Völker, Kenji Wakai, Melanie Waldenberger, Lars Wallentin, Stefan Wallner, Judy Wang, Dawn M Waterworth, Harvey D White, Cristen J Willer, Tien-Yin Wong, Mark Woodward, Qiong Yang, Laura M Yerges-Armstrong, Martina Zimmermann, Alan B Zonderman, Tobias Bergler, Kari Stefansson, Carsten A Böger, Cristian Pattaro, Anna Köttgen, Florian Kronenberg, Iris M Heid

Faculty, Staff and Student Publications

Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 individuals and in high-risk groups. We also explored different covariate adjustment. Twelve genome-wide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR-baseline (11 novel, one known for this phenotype), including nine …

Major Pathologic Response And Prognostic Score Predict Survival In Patients With Lung Cancer Receiving Neoadjuvant Chemotherapy, Apar Pataer, Annikka Weissferdt, Arlene M Correa, Ara A Vaporciyan, Boris Sepesi, John V Heymach, Sabina Berezowska, Tina Cascone, Stephen G Swisher

Faculty, Staff and Student Publications

INTRODUCTION: Complete pathologic response (CPR) is an acceptable surrogate for survival in clinical trials but it occurs infrequently in patients with NSCLC receiving neoadjuvant chemotherapy (NCT). Therefore, we studied the impact of major pathologic response (MPR) for predicting survival of patients with NSCLC receiving NCT. We also tested a newly reported scoring system-the prognostic score (PRSC)-which combines T category, lymph node status, and MPR status.

METHODS: We analyzed CPR and MPR, defined as 0% and less than or equal to 10% viable tumor cells, respectively, in 339 patients with NSCLC with various histologic types who had been treated with NCT …

Tumor Immune Microenvironment Changes By Multiplex Immunofluorescence Staining In A Pilot Study Of Neoadjuvant Talazoparib For Early-Stage Breast Cancer Patients With A Hereditary Brca Mutation, Tapsi Kumar, Evie Hobbs, Fei Yang, Jeffrey T Chang, Alejandro Contreras, Edwin Roger Parra Cuentas, Haven Garber, Sanghoon Lee, Yiling Lu, Marion E Scoggins, Beatriz E Adrada, Gary J Whitman, Banu K Arun, Elizabeth A Mittendorf, Jennifer K Litton

Faculty, Staff and Student Publications

PURPOSE: The immunological profile of early-stage breast cancer treated with neoadjuvant PARP inhibitors has not been described. The aim of this study was to delineate the changes in the tumor immune microenvironment (TiME) induced by talazoparib.

PATIENTS AND METHODS: Patients with operable germline BRCA1/2 pathogenic variant (gBRCA1/2+) breast cancer were enrolled in a feasibility study of neoadjuvant talazoparib. Thirteen patients who received 8 weeks of neoadjuvant talazoparib were available for analysis, including 11 paired pre- and post-talazoparib core biopsies. Treatment-related changes in tumor-infiltrating lymphocytes were examined and immune cell phenotypes and their spatial distribution in the TiME were identified and …

Confirming Subarachnoid Hemorrhage Induction In The Endovascular Puncture Mouse Model, Ari Dienel, Sung-Ha Hong, Jose Guzman, Kumar T Peeyush, Spiros L Blackburn, Devin W Mcbride

Faculty, Staff and Student Publications

Background and purpose: Experimental studies of subarachnoid hemorrhage (SAH) using the endovascular perforation model routinely use either cerebral blood flow (CBF) or intracranial pressure (ICP) monitoring to confirm SAH induction. We designed this study to test the hypothesis that contralateral CBF is a better marker of SAH induction than ipsilateral CBF.

Methods: Sixty-eight adult C57BL/6J mice were subjected to endovascular perforation. Mice were monitored using laser Doppler (for relative CBF) or ICP probes.

Results: The ipsilateral CBF significantly decreased prior to ICP rising. However, reduction of the CBF in the contralateral hemisphere occurred at the same time as the rise …

Idh1 Prr32h Ctdna And D-2-Hydroxyglutarate As Csf Biomarkers In Patients With Idh-Mutant Gliomas, Yoko Fujita, Luis Nunez-Rubiano, Antonio Dono, Allison Bellman, Mauli Shah, Juan C Rodriguez, Vasanta Putluri, Abu Hena Mostafa Kamal, Nagireddy Putluri, Roy F Riascos, Jay-Jiguang Zhu, Yoshua Esquenazi, Leomar Y Ballester

Faculty, Staff and Student Publications

INTRODUCTION: We aimed to evaluate IDH1 p.R132H mutation and 2-hydroxyglutarate (2HG) in cerebrospinal fluid (CSF) as biomarkers for patients with IDH-mutant gliomas.

METHODS: CSF was collected from patients with infiltrating glioma, and 2HG levels were measured by liquid chromatography-mass spectrometry. IDH1 p.R132H mutant allele frequency (MAF) in CSF-ctDNA was measured by digital droplet PCR (ddPCR). Tumor volume was measured from standard-of-care magnetic resonance images.

RESULTS: The study included 48 patients, 6 with IDH-mutant and 42 with IDH-wildtype gliomas, and 57 samples, 9 from the patients with IDH-mutant and 48 from the patients with IDH-wildtype gliomas. ctDNA was detected in 7 …

Plasmonic Gadolinium Oxide Nanomatryoshkas: Bifunctional Magnetic Resonance Imaging Enhancers For Photothermal Cancer Therapy, Luke Henderson, Oara Neumann, Yara Kadria-Vili, Burak Gerislioglu, James Bankson, Peter Nordlander, Naomi J Halas

Faculty, Staff and Student Publications

Nanoparticle-assisted laser-induced photothermal therapy (PTT) is a promising method for cancer treatment; yet, visualization of nanoparticle uptake and photothermal response remain a critical challenge. Here, we report a magnetic resonance imaging-active nanomatryoshka (Gd2O3-NM), a multilayered (Au core/Gd2O3 shell/Au shell) sub-100 nm nanoparticle capable of combining T1 MRI contrast with PTT. This bifunctional nanoparticle demonstrates an r1 of 1.28 × 108 mM-1 s-1, an MRI contrast enhancement per nanoparticle sufficient for T1 imaging in addition to tumor ablation. Gd2O3-NM also shows excellent stability in an acidic environment, retaining 99% of the internal Gd(3). This report details the synthesis and characterization of …

Automation Of Radiation Treatment Planning For Rectal Cancer, Kai Huang, Prajnan Das, Adenike M Olanrewaju, Carlos Cardenas, David Fuentes, Lifei Zhang, Donald Hancock, Hannah Simonds, Dong Joo Rhee, Sam Beddar, Tina M Briere, Laurence Court

Faculty, Staff and Student Publications

PURPOSE: To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy (3DCRT) treatment planning that combines deep learning (DL) aperture predictions and forward-planning algorithms.

METHODS: We designed an algorithm to automate the clinical workflow for 3DCRT planning with field aperture creations and field-in-field (FIF) planning. DL models (DeepLabV3+ architecture) were trained, validated, and tested on 555 patients to automatically generate aperture shapes for primary (posterior-anterior [PA] and opposed laterals) and boost fields. Network inputs were digitally reconstructed radiographs, gross tumor volume (GTV), and nodal GTV. A physician scored each aperture for 20 patients on a 5-point scale (>3 …

Introduction To Mathematical Analysis I - 3rd Edition, Beatriz Lafferriere, Gerardo Lafferriere, Mau Nam Nguyen

PDXOpen: Open Educational Resources

Video lectures explaining problem solving strategies are available.

This set of lecture notes is meant to provide students with a strong foundation in mathematical analysis. Such a foundation is crucial for future study of deeper topics of analysis. Students should be familiar with most of the concepts presented here after completing the calculus sequence. However, these concepts will be reinforced through rigorous proofs.

Introduction to Mathematical Analysis II contains lecture notes that complement this book, with sections on integration, numerical series, series of functions, and selected advanced topics. Together, both volumes support a one semester or two-quarter course on introductory …

Crafting Strategy For Irregular Warfare: A Framework For Analysis And Action (2nd Edition), David H. Ucko, Thomas A. Marks

Strategic Monographs

The United States, and the West, struggle to understand and respond to irregular warfare, whether by states or nonstate actors. Attempts to master the art have generated much new jargon, ranging from “hybrid war” to “the gray zone,” and most recently “integrated deterrence.” The terminology belies a struggle to overcome entrenched presumptions about war—a confusion that generates cognitive friction with implications for strategy. To inform a better approach, this monograph presents an analytical framework to assess and respond to irregular threats.

Modelling Of Cohesive Expandable Lcms For Fractures With Large Apertures, Lu Lee, Musaab Magzoub, Arash Dahi Taleghani, Saeed Salehi, Guoqiang Li

Faculty Publications

The problem of loss circulation in geothermal wells is inherently challenging due to high temperatures, brittle rocks, and presence of abundant fractures. Because of the inherent challenges in geothermal environments, there are limitations in selecting proper lost circulation materials (LCMs). Traditional LCMs such as calcium carbonates that are commonly used in the oil and gas drilling may be softened and prone to failure during geothermal drilling. Moreover, evaluating the performance of different LCMs for geothermal drilling requires unique testing setups, which is expensive, and complicated to run due to harsh environmental conditions of geothermal systems. Herein, we present a numerical …

Thermal, Physical, And Optical Properties Of The Solution And Melt Synthesized Single Crystal Cspbbr3 Halide Perovskite, Kirti Agrawal, Syed Mohammad Abid Hasan, Joanna Blawat, Nishir Mehta, Yuming Wang, Rafael Cueto, Miriam Siebenbuerger, Orhan Kizilkaya, Narasimha S. Prasad, James Dorman, Rongying Jin, Manas Ranjan Gartia

Faculty Publications

Inorganic lead-halide perovskite, cesium lead bromide (CsPbBr3), shows outstanding optoelectronic properties. Both solution- and melt-based methods have been proposed for CsPbBr3 crystal growth. The solution-based growth was done at low-temperature, whereas the melt-based growth was done at high-temperature. However, the comparison of optical, physical, and defect states using these two different growth conditions has been scarcely studied. Here, we have compared the thermal and optical properties of solution-grown and melt-grown single crystals of CsPbBr3. Positron Annihilation Lifetime Spectroscopy (PALS) analysis showed that melt-grown crystal has a relatively smaller number of defects than the chemical synthesis method. In addition, crystals grown …