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Crisis Ocean Modelling With A Relocatable Operational Forecasting System And Its Application To The Lakshadweep Sea (Indian Ocean), Georgy I. Shapiro, Jose M. Gonzalez-Ondina, Mohammed Salim, Jiada Tu, Muhammad Asif Oct 2022

Crisis Ocean Modelling With A Relocatable Operational Forecasting System And Its Application To The Lakshadweep Sea (Indian Ocean), Georgy I. Shapiro, Jose M. Gonzalez-Ondina, Mohammed Salim, Jiada Tu, Muhammad Asif

School of Biological and Marine Sciences

This study presents the Relocatable Operational Ocean Model (ReOMo), which can be used as a Crisis Ocean Modelling System in any region of the global ocean that is free from ice. ReOMo can be quickly nested into an existing coarser resolution (parent) model. The core components of ReOMo are the NEMO hydrodynamic model and Rose-Cylc workflow management software. The principal innovative feature of ReOMo is the use of the Nesting with Data Assimilation (NDA) algorithm, which is based on the model-to-model assimilation technique. The NDA utilises the full 3D set of field variables from the parent model rather than just …


The George-Anne Daily, Georgia Southern University Oct 2022

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.


The George-Anne Inkwell Edition Oct 2022

The George-Anne Inkwell Edition

The Inkwell

No abstract provided.


The Flaws Of Magic Bullet Theory: Retraining Unconscionability To Discretely Target Different Contexts Of Unfairness In Contracts, Marcus Moore Oct 2022

The Flaws Of Magic Bullet Theory: Retraining Unconscionability To Discretely Target Different Contexts Of Unfairness In Contracts, Marcus Moore

All Faculty Publications

Unconscionability has long been a troublesome area in Canadian jurisprudence. This is of significant concern given unconscionability’s pre-eminence as a protection of contractual fairness. This article elaborates a much-needed reorganization and rationalization of unconscionability in Canada. Under current law, a single doctrine hopelessly targets two divergent purposes. I set out here a proposed redevelopment rather of separate common law doctrines, each fit-for-purpose: (1) An English-style unconscionable bargains doctrine for avoiding bargains that exploited disability, and (2) an American-style unconscionable clauses doctrine to control unfair terms in standard form contracts. Extensive Canadian precedent supports this solution, assuring its feasibility and legitimacy. …


Novel Chelating Agents For Zirconium-89-Positron Emission Tomography (Pet) Imaging: Synthesis, Dft Calculation, Radiolabeling, And In Vitro And In Vivo Complex Stability, Chi Soo Kang, Shuyuan Zhang, Haixing Wang, Yujie Liu, Siyuan Ren, Yanda Chen, Jingbai Li, Nilantha Bandara, Andrey Yu Rogachev, Buck E Rogers, Hyun-Soon Chong Oct 2022

Novel Chelating Agents For Zirconium-89-Positron Emission Tomography (Pet) Imaging: Synthesis, Dft Calculation, Radiolabeling, And In Vitro And In Vivo Complex Stability, Chi Soo Kang, Shuyuan Zhang, Haixing Wang, Yujie Liu, Siyuan Ren, Yanda Chen, Jingbai Li, Nilantha Bandara, Andrey Yu Rogachev, Buck E Rogers, Hyun-Soon Chong

2020-Current year OA Pubs

We report the synthesis and evaluation of novel chelating agents for zirconium-89 (


Ring-Fused 2-Pyridones Effective Against Multidrug-Resistant Gram-Positive Pathogens And Synergistic With Standard-Of-Care Antibiotics, Taylor M Nye, Hasan Tükenmez, Pardeep Singh, Ana L Flores-Mireles, Chloe L P Obernuefemann, Jerome S Pinkner, Souvik Sarkar, Mari Bonde, Anders E G Lindgren, Karen W Dodson, Jörgen Johansson, Fredrik Almqvist, Michael G Caparon, Scott J Hultgren Oct 2022

Ring-Fused 2-Pyridones Effective Against Multidrug-Resistant Gram-Positive Pathogens And Synergistic With Standard-Of-Care Antibiotics, Taylor M Nye, Hasan Tükenmez, Pardeep Singh, Ana L Flores-Mireles, Chloe L P Obernuefemann, Jerome S Pinkner, Souvik Sarkar, Mari Bonde, Anders E G Lindgren, Karen W Dodson, Jörgen Johansson, Fredrik Almqvist, Michael G Caparon, Scott J Hultgren

2020-Current year OA Pubs

The alarming rise of multidrug-resistant Gram-positive bacteria has precipitated a healthcare crisis, necessitating the development of new antimicrobial therapies. Here we describe a new class of antibiotics based on a ring-fused 2-pyridone backbone, which are active against vancomycin-resistant enterococci (VRE), a serious threat as classified by the Centers for Disease Control and Prevention, and other multidrug-resistant Gram-positive bacteria. Ring-fused 2-pyridone antibiotics have bacteriostatic activity against actively dividing exponential phase enterococcal cells and bactericidal activity against nondividing stationary phase enterococcal cells. The molecular mechanism of drug-induced killing of stationary phase cells mimics aspects of fratricide observed in enterococcal biofilms, where both …


Friendship As The Primary Purpose Of Law, Michael P. Moreland Oct 2022

Friendship As The Primary Purpose Of Law, Michael P. Moreland

Faculty Publications

A significant aspect of the legacy of John Finnis is the restoration of friendship to a central place in moral, political, and legal theory building on the classical tradition in Plato, Aristotle, and Aquinas. This essay surveys the implications of friendship for law by way of exploring Finnis’s treatment of friendship in several of his works, including friendship as a condition for discourse, friendship as an especially important illustration of the central case, the relationship between friendship and the common good, and the place of civic friendship in a political community. The essay concludes with a discussion of friendship with …


Word Document Example Of A -Zine, Christian Jon Peshlakai, Midjourney, Https://Howtodotechystuff.Wordpress.Com/2019/11/20/Heres-A-Word-Label-Template-For-Printing-An-8-Page-Zine-From-One-A4-Sheet/ Oct 2022

Word Document Example Of A -Zine, Christian Jon Peshlakai, Midjourney, Https://Howtodotechystuff.Wordpress.Com/2019/11/20/Heres-A-Word-Label-Template-For-Printing-An-8-Page-Zine-From-One-A4-Sheet/

University Libraries & Learning Sciences Faculty and Staff Publications

Vague instructions on utilizing a -zine template from https://howtodotechystuff.wordpress.com/2019/11/20/heres-a-word-label-template-for-printing-an-8-page-zine-from-one-a4-sheet/ , and adapting it to create a -zine within Photoshop to easily create instruction on the creation of a -zine.


Faculty Recital Series: Ben Stiers, Percussion; Andy Rummel, Tuba; Baryl Brandt, Vibraphone; Noah Berkshier, Marimba; Sara Eckert, Marimba; October 25, 2022, Ben Stiers, Andy Rummel, Baryl Brandt, Noah Berkshier, Sara Eckert Oct 2022

Faculty Recital Series: Ben Stiers, Percussion; Andy Rummel, Tuba; Baryl Brandt, Vibraphone; Noah Berkshier, Marimba; Sara Eckert, Marimba; October 25, 2022, Ben Stiers, Andy Rummel, Baryl Brandt, Noah Berkshier, Sara Eckert

School of Music Programs

Kemp Recital Hall
October 25, 2022
Tuesday Evening
8:00 p.m.


Recombinant Protein Micelles To Block Transduction By Sars-Cov-2 Pseudovirus, Rajarshi Chattaraj, Christina Y Kim, Daeyeon Lee, Daniel A Hammer Oct 2022

Recombinant Protein Micelles To Block Transduction By Sars-Cov-2 Pseudovirus, Rajarshi Chattaraj, Christina Y Kim, Daeyeon Lee, Daniel A Hammer

Faculty, Staff and Student Publications

The continuing emergence of variants of the SARS-CoV-2 virus requires the development of modular molecular therapies. Here, we engineered a recombinant amphiphilic protein, oleosin, to spontaneously self-assemble into multivalent micellar nanostructures which can block the Spike S1 protein of SARS-CoV-2 pseudoviruses (PVs). Short recombinant proteins like oleosin can be formulated more easily than antibodies and can be functionalized with precision through genetic engineering. We cloned S1-binding mini-protein genes called LCB


Risk Factors Of Female-Perpetrated Intimate Partner Violence Among Hispanic Young Adults: Attachment Style, Emotional Dysregulation, And Negative Childhood Experiences, Joahana Segundo, Arturo L. Cantos, Gabriela Ontiveros, K. Daniel O'Leary Oct 2022

Risk Factors Of Female-Perpetrated Intimate Partner Violence Among Hispanic Young Adults: Attachment Style, Emotional Dysregulation, And Negative Childhood Experiences, Joahana Segundo, Arturo L. Cantos, Gabriela Ontiveros, K. Daniel O'Leary

Psychological Science Faculty Publications

This paper examined whether risk factors commonly associated with intimate partner violence (IPV) are associated with female-perpetrated physical IPV and female physical IPV victimization among young Hispanic women. It also examined how emotion dysregulation, impulsivity, and attachment style exacerbated these relationships. Furthermore, it investigates how these associations differ by the type of self-reported physical violence against their romantic partner. Based on the participants' self-reported physical violence, they were classified into one of four groups: nonviolent, victim-only, perpetrator-only, and bidirectionally violent. Bidirectional violence was by far the most common form of violence reported. Utilizing self-report data from 360 young Hispanic women, …


Understanding How Language Revitalisation Works: A Realist Synthesis, Brandon Wiltshire, Steven Bird, Rebecca Hardwick Oct 2022

Understanding How Language Revitalisation Works: A Realist Synthesis, Brandon Wiltshire, Steven Bird, Rebecca Hardwick

Peninsula Medical School

Indigenous communities, linguists, teachers, and language activists have been developing methods to revitalise endangered languages over several decades. Not only are these methods diverse, they are usually implemented in various ways according to local needs and aspirations. Language revitalisation methods focus on proficiency, but there is also interest in strengthening identity, resilience, and wellbeing. Aside from a handful of successes, programs may not be achieving desired outcomes. One could try to evaluate specific programs. However, we believe that a necessary first step is to examine published literature of revitalisation efforts to develop initial understandings of how they work. In particular, …


Designing Public Policy To Support Entrepreneurial Activity Within The Disabled Community In Ireland, Thomas M. Cooney Oct 2022

Designing Public Policy To Support Entrepreneurial Activity Within The Disabled Community In Ireland, Thomas M. Cooney

Research Outputs: 2025-Present

No abstract provided.


Tesla Transformation And Hidden Champions: The Pace Of Innovation It The Only Thing That Matters In The Long Run., Jan-Philipp BüChler Prof. Dr. Oct 2022

Tesla Transformation And Hidden Champions: The Pace Of Innovation It The Only Thing That Matters In The Long Run., Jan-Philipp BüChler Prof. Dr.

Case Studies

After having internally invested significant amounts of time and resources into customer-specific development, the CEO of CoMaTec - family-owned and mid-sized world-market leader in the automotive industry - receives the contract for batch production from emerging electric automotive giant TESLA. However, the timing for the final development stage and start of production (SOP) deviates distinctly from all prior agreements. The tightened timing would put his company at tremendous risk. Should he accept the contract? Which mitigation strategies present an option for managing the emerging risks?


Antihypertensives In Dementia: Good Or Bad For The Brain?, Lucy Beishon, Victoria J. Haunton, Ronney B. Panerai Oct 2022

Antihypertensives In Dementia: Good Or Bad For The Brain?, Lucy Beishon, Victoria J. Haunton, Ronney B. Panerai

Peninsula Medical School

Hypertension is associated with both ageing and dementia. Despite this, optimal blood pressure targets in dementia remain unclear. Both high and low blood pressure are associated with poorer cognition. Changes in vascular physiology in dementia may increase the vulnerability of the brain to hypoperfusion associated with antihypertensives. We discuss the potential risks of antihypertensives in the context of altered cerebral haemodynamics, and evidence from antihypertensive trials in dementia. We suggest that individualised blood pressure targets should be the focus for antihypertensive therapy in dementia, rather than strict control to uniform targets extrapolated from trials in cognitively healthy individuals.


Cardiorespiratory Fitness Is A Risk Factor For Lower-Limb And Back Injury In Law Enforcement Officers Commencing Their Basic Training: A Prospective Cohort Study, Myles C. Murphy, Nicole Merrick, Andrea B. Mosler, Garth Allen, Paola Chivers, Nicolas H. Hart Oct 2022

Cardiorespiratory Fitness Is A Risk Factor For Lower-Limb And Back Injury In Law Enforcement Officers Commencing Their Basic Training: A Prospective Cohort Study, Myles C. Murphy, Nicole Merrick, Andrea B. Mosler, Garth Allen, Paola Chivers, Nicolas H. Hart

Research outputs 2022 to 2026

We aimed to report the epidemiology of lower-limb and lumbosacral injuries in Police Force recruits. We performed a cohort study of Police Force recruits undergoing a six-month training program with prospective injury data collected between 2018 and 2021. Cardiorespiratory fitness was quantified by the beep-test and police-specific-functional-capacity was quantified using a specifically designed physical performance evaluation (PPE) tool. Injury frequency and prevalence were reported. Fifteen percent (n = 180) of study Police Force recruits (n = 1,181) sustained a lower-limb or lumbosacral injury. The six-month training program significantly improved cardiorespiratory fitness (p < 0.001) and functional capacity (p < 0.001). Increased cardiorespiratory fitness at baseline decreased injury risk (OR = 0.8, 95%CI: 0.66–0.97, p = 0.019). Injury rates decreased over time and females were injured significantly earlier than males (HR = 0.70, 95%CI: 0.52 to 0.95, p = 0.021). Interventions that can pre-condition Police Force recruits prior to the commencement of their basic physical training may reduce the number of lower-limb and lumbosacral injuries.


‘Meet New Vcd’ Immersive Art Gallery, Wenting Toby Xue Oct 2022

‘Meet New Vcd’ Immersive Art Gallery, Wenting Toby Xue

Theses

Students of the Visual Communication Design (VCD) program may have a relatively distressing question about how to explain some details of this program to others. Someone will always ask how to define and explain the VCD. Therefore, in the spirit of redefining the VCD program and creating a platform to more intuitively demonstrate the current success of VCD students in visual design. The curriculum of this program and related student works are mainly user-centered design as the primary starting point. Innovation and forward-looking are necessary. To better communicate the VCD project and expand its influence. According to the questionnaire and …


Cantor V. New York State Div. Of Hous. & Community Renewal Oct 2022

Cantor V. New York State Div. Of Hous. & Community Renewal

All Decisions

No abstract provided.


Mr. Stanley White Oct 2022

Mr. Stanley White

African American Funeral Programs

Mr_Stanley_White.pdf - Funeral program for Mr. Stanley White


An Active Biodegradable Layer-By-Layer Film Based On Chitosan-Alginate-Tio2 For The Enhanced Shelf Life Of Tomatoes, Kalpani Y. Perera, Shubham Sharma, Brendan Duffy, Shiviani Pathania, Amit K. Jaiswal, Swarma Jaiswal Oct 2022

An Active Biodegradable Layer-By-Layer Film Based On Chitosan-Alginate-Tio2 For The Enhanced Shelf Life Of Tomatoes, Kalpani Y. Perera, Shubham Sharma, Brendan Duffy, Shiviani Pathania, Amit K. Jaiswal, Swarma Jaiswal

Articles

This work aims at developing biodegradable active chitosan-alginate layer-by-layer bio-nanocomposite film with TiO2NPs using the solvent casting method followed by CaCl2 crosslinking for food packaging applications. The developed films enhanced the tensile strength and elongation at break by 14.76 and 2 folds (p < 0.05) respectively. The UV barrier properties of CH-SA-0.3%TiO2 film increased by 88.6%, while the film transparency decreased by 87.23%. All films showed antimicrobial activity against foodborne pathogens E. coli, S. aureus, S. typhi, and L. monocytogene. The film with 0.1%TiO2 showed the complete killing of gram-positive bacteria. The CH-SA-0.1%TiO2 film was completely biodegraded during the …


Acg 2021 Laparoscopic Assisted Enteroscopy With A Pediatric Colonoscope In Peutz-Jeghers Syndrome Surveillance, Matthew Kobeszko, Ahmed Akhter Oct 2022

Acg 2021 Laparoscopic Assisted Enteroscopy With A Pediatric Colonoscope In Peutz-Jeghers Syndrome Surveillance, Matthew Kobeszko, Ahmed Akhter

Aurora GME

No abstract provided.


Acg 2021 Covid-19 Induced Persistent Jaundice With Secondary Sclerosing Cholangitis, Matthew Kobeszko, Nilay Kumar Oct 2022

Acg 2021 Covid-19 Induced Persistent Jaundice With Secondary Sclerosing Cholangitis, Matthew Kobeszko, Nilay Kumar

Aurora GME

No abstract provided.


Algorithmic Design Of 3d Wireframe Rna Polyhedra, Antti Elonen, Ashwin Karthick Natarajan, Ibuki Kawamata, Lukas Oesinghaus, Abdulmelik Mohammed, Jani Seitsonen, Yuki Suzuki, Friedrich C. Simmel, Anton Kuzyk, Pekka Orponen Oct 2022

Algorithmic Design Of 3d Wireframe Rna Polyhedra, Antti Elonen, Ashwin Karthick Natarajan, Ibuki Kawamata, Lukas Oesinghaus, Abdulmelik Mohammed, Jani Seitsonen, Yuki Suzuki, Friedrich C. Simmel, Anton Kuzyk, Pekka Orponen

Faculty Research, Scholarly, and Creative Activity

We address the problem of de novo design and synthesis of nucleic acid nanostructures, a challenge that has been considered in the area of DNA nanotechnology since the 1980s and more recently in the area of RNA nanotechnology. Toward this goal, we introduce a general algorithmic design process and software pipeline for rendering 3D wireframe polyhedral nanostructures in single-stranded RNA. To initiate the pipeline, the user creates a model of the desired polyhedron using standard 3D graphic design software. As its output, the pipeline produces an RNA nucleotide sequence whose corresponding RNA primary structure can be transcribed from a DNA …


Microbusinesses Practices During Disruptor Events: Perceptions, Adaptations, And Performance, Debra Lynn Frank Oct 2022

Microbusinesses Practices During Disruptor Events: Perceptions, Adaptations, And Performance, Debra Lynn Frank

USF Tampa Graduate Theses and Dissertations

During COVID-19 closures, business owners and managers experienced a disruptor event that pushed them to find new ways to navigate their businesses practices. The purpose of this qualitative study was to learn how business owners and managers adapt their business models to survive disruptor events. The objective was identification of factors owners and managers of microbusinesses perceived as critical to avoiding closures, assessment of the effectiveness of the adaptations adopted during closures that enabled businesses to remain open, and analysis of the results of those adaptations. Owners and managers of businesses in the craft brewing industry were interviewed. The four …


An Object For Sexual Pleasure: Does Viewing Sexualized Media Predict Increases In Self And Partner Objectification Impacting Feelings Of Sexual And Romantic Closeness?, Kaitlyn Ligman Oct 2022

An Object For Sexual Pleasure: Does Viewing Sexualized Media Predict Increases In Self And Partner Objectification Impacting Feelings Of Sexual And Romantic Closeness?, Kaitlyn Ligman

USF Tampa Graduate Theses and Dissertations

Exposure to sexually objectifying media has been linked to the objectification of the self and of one’s romantic partner (e.g., partner-objectification); yet the implications of this for romantic relationships have remained relatively unexamined. There is, however, reason to suspect that exposure to sexually objectifying media and engaging in objectification may have implications for romantic couples. When a woman frequently monitors her appearance this may undermine her ability to sexually connect with her partner and when a man views his partner as an object for sexual pleasure it may impede his ability to develop intimate feelings of relational closeness to his …


Organizing For Here And There: Exploring The Grassroots Organizing Of The Puerto Rican Diaspora In The Tampa Bay Area, Dominique Rivera Oct 2022

Organizing For Here And There: Exploring The Grassroots Organizing Of The Puerto Rican Diaspora In The Tampa Bay Area, Dominique Rivera

USF Tampa Graduate Theses and Dissertations

Drawing upon participant observations and semi-structure interviews with 10 Puerto Rican grassroots organizers from the Tampa Bay area of Florida, this project examines the processes by which Puerto Rican diaspora members build, maintain, and utilize social and symbolic ties as resources for organizing and executing grassroot projects and campaigns with a dual focus on the Puerto Rican community in the Tampa Bay area and in Puerto Rico. Complex webs of interlocking social and symbolic ties that transcend region of origin and regions of destination constitute a transnational social field, within which exchanges of ideas, practices, and resources are organized among …


Deceptive Appeals And Cognitive Influences Used In Fraudulent Scheme Sales Pitches, Rafael J. Toledo Oct 2022

Deceptive Appeals And Cognitive Influences Used In Fraudulent Scheme Sales Pitches, Rafael J. Toledo

USF Tampa Graduate Theses and Dissertations

Fraud schemes exploit the complex interplay that results from utilizing deceptive appeals to activate underlying cognitive influences. This study was designed, first, to identify the deceptive appeals present in the messaging of fraudulent schemes and, second, to identify the underlying cognitive influences being exploited by the deceptive appeals utilized. Findings reveal that effectively used deceptive appeals work to keep viewers’ mental processes in a state of cognitive ease. This state allows cognitive influences--such as heuristics, cognitive biases, and the System 1 mind--to remain in control of mental processing; however, System 1 is prone to accept deceptive beliefs. The results of …


Interferon Signaling In The Endometrium And In Endometriosis, Yuri Park, Sang Jun Han Oct 2022

Interferon Signaling In The Endometrium And In Endometriosis, Yuri Park, Sang Jun Han

Faculty, Staff and Students Publications

Endometriosis is an estrogen-dependent inflammatory disease that develops in reproductive-aged women who experience pelvic pain and infertility. Even though endometriosis is not a new disease, its molecular etiology has not been clearly elucidated. Defects in the immune system might be one of the factors that promote endometriosis progression. For example, elevated levels of proinflammatory cytokines are associated with endometriosis. Interferon is one of the cytokines that is elevated in endometriotic tissues compared with normal endometrium. Therefore, high interferon levels play a crucial role in endometriosis progression. In addition to endometriosis, however, interferon has a critical role in endometrial function, particularly …


14-3-3Τ Drives Estrogen Receptor Loss Via Erα36 Induction And Gata3 Inhibition In Breast Cancer, Lidija A Wilhelms Garan, Yang Xiao, Weei-Chin Lin Oct 2022

14-3-3Τ Drives Estrogen Receptor Loss Via Erα36 Induction And Gata3 Inhibition In Breast Cancer, Lidija A Wilhelms Garan, Yang Xiao, Weei-Chin Lin

Faculty, Staff and Students Publications

About one-fourth of recurrent estrogen receptor-positive (ER+) breast cancers lose ER expression, leading to endocrine therapy failure. However, the mechanisms underlying ER loss remain to be fully explored. We now show that 14-3-3τ, up-regulated in ∼60% of breast cancer, drives the conversion of ER+ to ER- and epithelial-to-mesenchymal transition (EMT). We identify ERα36, an isoform of ERα66, as a downstream effector of 14-3-3τ. Overexpression of 14-3-3τ induces ERα36 in xenografts and tumor spheroids. The regulation is further supported by a positive correlation between ERα36 and 14-3-3τ expression in human breast cancers. ERα36 can antagonize ERα66 and inhibit ERα66 expression. Isoform-specific …


A Participant-Level Integrative Data Analysis Of Differential Placebo Response For Suicidal Ideation And Nonsuicidal Depressive Symptoms In Clinical Trials Of Intravenous Racemic Ketamine, Bartholt Bloomfield-Clagett, Elizabeth D Ballard, Deanna K Greenstein, Samuel T Wilkinson, Michael F Grunebaum, James W Murrough, Sanjay J Mathew, Jennifer L Phillips, Maurizio Fava, Gerard Sanacora, Carlos A Zarate Oct 2022

A Participant-Level Integrative Data Analysis Of Differential Placebo Response For Suicidal Ideation And Nonsuicidal Depressive Symptoms In Clinical Trials Of Intravenous Racemic Ketamine, Bartholt Bloomfield-Clagett, Elizabeth D Ballard, Deanna K Greenstein, Samuel T Wilkinson, Michael F Grunebaum, James W Murrough, Sanjay J Mathew, Jennifer L Phillips, Maurizio Fava, Gerard Sanacora, Carlos A Zarate

Staff and Researcher Publications

Background: Clinical trials of intravenous (IV) racemic (R,S)-ketamine (hereafter referred to as IV ketamine) have consistently reported rapid and substantial reductions in overall depressive symptoms compared with saline (inactive placebo) or midazolam (active placebo). The evidence for IV ketamine's specific effects on suicidal ideation is less clear, however. This study sought to examine whether differential placebo (saline or midazolam) response to overall depressive symptoms vs suicidal ideation may help explain these divergent findings.

Methods: Data for this participant-level integrative data analysis were drawn from 151 participants across 10 studies, and linear regression was used to examine the relationship between placebo …