Digital Commons Network^™

Sevoflurane Reverses Cisplatin Resistance In Neuroblastoma Cells Through The Linc00473/Mir-490-5p/Akt1 Axis, Huiqing Li, Xiaobo Fu, Huiyu Guo, Yue Sun, Di Wang, Zengzhen Zhang

Saudi Medical Journal

Objectives: To determine whether sevoflurane regulates cisplatin resistance in neuroblastoma cells. Methods: The SH-SY5Y cell line with cisplatin-resistant phenotype (SH-SY5Y-SR) was generated. Cells were co-treated with sevoflurane and cisplatin to seek the sevoflurane function on cisplatin resistance. Key targets of sevoflurane treatment were determined using sequencing (ribonucleic acid [RNA-seq]). Cells were then transfected with specific vectors. Linc00473 and microRNA-490-5p (miR-490-5p) levels were detected using reverse transcriptase quantitative real-time reverse transcription PCR (RT-qPCR). Linc00473-miR-490-5p binding was confirmed using a luciferase reporter-gene assay. After treatment, cell proliferation, viability, and caspase-3 activity were measured to determine the effects of treatment on tumor cells. …

Clinical Significance Of Ca-125 In Elderly Patients With Active Pulmonary Tuberculosis: A Retrospective Study, Ping Zhao, Liang Chen, Ze Q. Xie, Ji Y. Jian, Pan P. Sun

Saudi Medical Journal

Objectives: To assess the clinical significance of serum CA-125 levels in elderly patients with pulmonary tuberculosis (PTB). Methods: We retrospectively analyzed 1613 participants–patients (aged ≥60 years) admitted to the Beijing Shijitan Hospital, Beijing, China from February 2015 to January 2021 and healthy participants, divided into 4 groups: PTB (group 1), pulmonary malignancies (group 2), pulmonary non-malignant diseases (group 3), and healthy participants (group 4). Data concerning demographics, physical examination findings, computed tomography, histopathological examination, and laboratory tests for Mycobacterium tuberculosis and serum CA-125 levels were collected and analyzed. Results: There were 720 healthy individuals and 893 patients in the study. …

Antibacterial And Anti-Biofilm Activity Of Plumbagin Against Multi-Drug Resistant Clinical Bacterial Isolates, Mohammad A. Alfhili, Irfan Ahmad, Yasser Alraey, Abdulaziz Alangari, Taha Alqahtani, Ayed A. Dera

Saudi Medical Journal

Objectives: To evaluate the antibacterial activity of plumbagin (PGN) against multidrug resistance (MDR) clinical isolates. Methods: This study was carried out at the Department of Clinical Lab Sciences, King Khalid University from October 6, 2021 to December 14, 2021. We investigated the antibacterial and anti-virulence activity of PGN against MDR Gram-negative ( Escherichia coli , Klebsiella pneumoniae , Salmonella Typhi , and Pseudomonas aeruginosa ) and Gram-positive ( Staphylococcus aureus [S. aureus] , Staphylococcus saprophyticus [S. saprophyticus] , Streptococcus pyogenes , and Enterococcus faecalis ) clinical bacterial isolates. Agar well diffusion, microdilution assay, colony count method, biofilm formation, and time-kill …

Correlating Excessive Daytime Sleepiness With Body Mass Index, Waist Circumference, And Lipid Profile In Shift Workers, Diah Kurnia Mirawati, Naomi Ditya Sari, Yetty Hambarsari, Hanindia Riani Prabaningtyas, Pepi Budianto, Muhammad Hafizhan, Stefanus Erdana Putra

Saudi Medical Journal

Objectives: To determine the correlation between excessive daytime sleepiness and body mass index, waist circumference, and lipid profile of shift workers at Dr. Moewardi General Hospital, Surakarta. Methods: This cross-sectional study was carried out at the Dr. Moewardi Hospital, Surakarta, Indonesia between October 2018 and July 2019. The participants were recruited using purposive sampling. Multiple linear regression with backward elimination was performed to identify the odds ratios between Epworth Sleepiness Scale scores, anthropometric measurements, and lipid profiles. A p -value of <0.05 indicated statistically significant correlations. Results: Of the 150 included participants, 127 (84.67%) were women. Statistical analyses revealed odds ratios of 2.38 (95% confidence interval [CI] 1.14-4.89, p =0.000) for daytime sleepiness severity and total cholesterol levels, and 2.45 (95% CI 1.36-4.98, p =0.020) for daytime sleepiness severity and high-density lipoprotein levels. Conclusion: Increased total cholesterol and decreased high-density lipoprotein levels increase the risk of excessive daytime sleepiness in shift workers.

The Prevalence Of Metabolic Syndrome Among University Students In Wasit, Iraq, Alaa H. Zamil, Seenaa S. Amin

Saudi Medical Journal

Objectives: To determine the prevalence of the metabolic syndrome (MetS) and its related risk factors in a group of healthy subjects. Methods: This cross-sectional analytic investigation used a convenient sample of 300 apparently healthy university students from Wasit, Iraq, between October 2021 and February 2022. The data was collected using a structured direct interview with a self-administered questionnaire. Anthropometric measurements (waist circumference [WC], body mass index [BMI], height, weight, and the blood pressure), total cholesterol level, triglyceride level, high-density lipoprotein (HDL-C), and fasting blood glucose (FBG) were all measured. IDF/AHA/NHLBI criteria were used to diagnose metabolic syndrome. Results: Overall, 41.3% …

Evaluation Of Clinical And Laboratory Characteristics And Factors Affecting Mortality In 500 Hospitalized Covid-19 Patients: A Retrospective Study, Petek Ş. Konya, Neşe Demirtürk, Derya Korkmaz, Havva Tünay, Elif Betül Koşar

Saudi Medical Journal

Objectives: To evaluate the clinical and laboratory characteristics of COVID-19 patients admitted to Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey, and to determine the factors affecting mortality. Methods: A total of 500 patients who were diagnosed with COVID-19 between 19th of March and 30th of September 2020 in Afyonkarahisar Health Sciences University, Faculty of Medicine, Pandemic Service, Afyonkarahisar, Turkey, were retrospectively investigated for this study. These individuals’ prognoses, demographic, clinical, laboratory, and radiological information were examined and recorded retrospectively. Comparisons were carried out between the characteristics of patients with a prognosis of death and those who recovered. Results: Of the 500 …

Evaluation Of Participation And Performance Indicators In A Breast Cancer Screening Program In Saudi Arabia, Yasser M. Alatawi, Hala A. Alshomrani, Sara M. Baeshen, Hayat H. Alkhamisi, Roaa M. Almazrui, Mohammed S. Alghamdi, Sara M. Bugshan, Tarik K. Alafif, Hussam A. Hijazi, Jawaher R. Alahmadi, Sawsan A. Ashoor, Ahmad M. Alamri, Faris Alkhilaiwi

Saudi Medical Journal

Objectives: To evaluate early performance indicators for breast cancer screening at the King Abdulaziz University Hospital in Saudi Arabia. Methods: This study retrospectively evaluated data from women who underwent their first breast cancer screening program in Jeddah, Saudi Arabia between 2012 and 2019. Data on screening results were used to estimate performance indicators and generate descriptive statistics. Results: Of the 16000 women invited from 2012 to 2019, a total of 1911 (11.9%) participated. The majority of women (68.8%) were between 40 and 55 years old. Based on the screening process results, 26.6%, 40.1%, 9.7%, 1.3%, 0.7%, and 5.2% of women …

Insight Into Sars-Cov-2 Omicron Variants In Saudi Arabian Genomic Isolates

Saudi Medical Journal

Objectives: To investigate the emergent mutations involved in the evolutionary stages of the virus for better management of pandemic. Methods: This cross-sectional genomic investigation was performed on February 28, 2022, at the Biology Department, Faculty of Science, Tabuk University. Numerous mutations were searched in genomic isolates of Omicron variant prevalent in the Kingdom of Saudi Arabian. Whole-genome sequences were retrieved from genomic databases and were subjected to the Global Initiative on Sharing Avian Influenza Data (GISAID) CoVsurver for the Omicron variant detection and mutations. Results: Approximately 8.755 million SARS-CoV-2 genomes were reported to GISAID on February 28, 2022, of which …

Erratum

Saudi Medical Journal

No abstract provided.

Do Caffeine And Alcohol Affect Fertility Treatments?

Saudi Medical Journal

No abstract provided.

Individuals With Inflammatory Breast Cancer At Higher Risk Of Cancer Spread To The Brain

Saudi Medical Journal

No abstract provided.

Clinicopathologic Features Of Renal Cell Carcinomas Seen At The Aga Khan University Hospital In Kenya, Anderson Mutuiri, Samuel Gakinya

Pathology, East Africa

Introduction: Kidney cancer accounted for 1. 8% of global cancer deaths according to Globocan 2020 estimates, with most of these being renal cell carcinomas. Lower rates of renal cell carcinoma are reported for Africa and these are expected to change for a combination of reasons. The clinical and morphologic characteristics of renal cell carcinoma seen within Kenya have not been described before. This study aims to partially fill this gap.

Materials and methods: This was a cross-sectional descriptive study examining electronic histopathology reports from the Aga Khan University Hospital Nairobi Laboratory for the period January 2016 to May 2022.

Results: …

Call Me By My Name, Shitong Lyu, Special Collections, Fleet Library

9th Baker & Whitehill Student Artists' Book Contest 2023

Entry for the 9th Annual Baker & Whitehill Student Artists' Book Contest. Opening Reception Thursday, March 02, 2023, Fleet Library, Main Reading Room. Juror: Andre Lee Bassuet.

My Wild Type Collection, Xinyu Hu, Special Collections, Fleet Library

9th Baker & Whitehill Student Artists' Book Contest 2023

Entry for the 9th Annual Baker & Whitehill Student Artists' Book Contest. Opening Reception Thursday, March 02, 2023, Fleet Library, Main Reading Room. Juror: Andre Lee Bassuet.

Between Book And People, Youjin (Amy) Lim, Special Collections, Fleet Library

9th Baker & Whitehill Student Artists' Book Contest 2023

Entry for the 9th Annual Baker & Whitehill Student Artists' Book Contest. Opening Reception Thursday, March 02, 2023, Fleet Library, Main Reading Room. Juror: Andre Lee Bassuet.

Survive, Haeun Um, Special Collections, Fleet Library

9th Baker & Whitehill Student Artists' Book Contest 2023

Entry for the 9th Annual Baker & Whitehill Student Artists' Book Contest. Opening Reception Thursday, March 02, 2023, Fleet Library, Main Reading Room. Juror: Andre Lee Bassuet.

Borderplex Business Barometer, Volume 6, Number 11, Thomas M. Fullerton Jr., Steven L. Fullerton

Border Region Modeling Project

No abstract provided.

The Effects Of Prior Trading Performance Have On Risk-Taking Of Subsequent Trading – The House Money Effect, Lenz Tan Koon Bin

Dissertations and Theses Collection (Open Access)

This study tests for house money effect on 2,030 non-professional FX investors trading through an Australian Financial Service provider. The results indicate that, in general, investors display a positive relationship between prior gains and the change in subsequent weekly risk-taking - the house money effect. The results also suggest that astute investors display a stronger house money effect than mediocre investors following prior gains. In comparison, mediocre investors display a stronger disposition effect following prior losses than astute investors. The study further reveals that investors who initially demonstrated the house money effect became more prone to the disposition effect during …

Autonomous Vehicle Innovation And Implications On Adoption, Liability And Policy, Using Quantum Technologies And Artificial Wisdom, Chia Jie Jun Jeremy

Dissertations and Theses Collection (Open Access)

This paper will explore the use of two new innovations for the issues facing autonomous vehicles (AV), those of quantum technologies and artificial wisdom. The issue of delayed at-scale commercialization and adoption of autonomous vehicles due to the extensive dynamic capability required to derive an optimal process solution for any complex, dynamic and adaptive autonomous vehicle ecosystem is shown to be resolved by the use of these innovations, will be shown to be more widely applicable for other issues for AV and for any scenario where automated decision making is required.

QC might open up the door for the application …

Mining Product Textual Data For Recommendation Explanations, Le Trung Hoang

Dissertations and Theses Collection (Open Access)

Recommendation explanations help to make sense of recommendations, increasing the likelihood of adoption. Here, we are interested in mining product textual data, an unstructured data type, coming from manufacturers, sellers, or consumers, appearing in many places including title, summary, description, review, question and answers, etc., can be a rich source of information to explain the recommendation. As the explanation task could be decoupled from that of recommendation objective, we can categorize recommendation explanation into integrated approach, that uses a single interpretable model to produce both recommendation and explanation, or pipeline approach, that uses a post-hoc explanation model to produce explanation …

Reinforcement Learning Approach To Coordinate Real-World Multi-Agent Dynamic Routing And Scheduling, Joe Waldy

Dissertations and Theses Collection (Open Access)

In this thesis, we study new variants of routing and scheduling problems motivated by real-world problems from the urban logistics and law enforcement domains. In particular, we focus on two key aspects: dynamic and multi-agent. While routing problems such as the Vehicle Routing Problem (VRP) is well-studied in the Operations Research (OR) community, we know that in real-world route planning today, initially-planned route plans and schedules may be disrupted by dynamically-occurring events. In addition, routing and scheduling plans cannot be done in silos due to the presence of other agents which may be independent and self-interested. These requirements create …

The Impact Of Board Heterogeneity On Corporate Internationalization Strategy, Yi Qiang

Dissertations and Theses Collection (Open Access)

This study analyzes the relationship between board heterogeneity and the company’s internationalization strategy to determine the internal mechanism through which board heterogeneity affects the company’s internationalization strategy. Based on the analysis of the primary effect, the moderating effects of contextual factors at various levels, such as individual, organization, and environment, are introduced. Subsequently, this study empirically tests the proposed research hypothesis using the data of Chinese listed companies from 2011 to 2020.

The empirical results indicate that board heterogeneity has a positive impact on the company’s internationalization strategy. When the board chairman is female or has a longer tenure, board …

Evaluation Of Sedimentary Bacterial Community Dynamics And Contamination Assessment Of Lower Des Plaines River, Philips O. Akinwole, Madeline C. Draper, Amerti Guta, Mahaila J. Martin

Biology Faculty publications

Urban rivers often contain elevated concentrations of contaminants such as organic pollutants and heavy metals which can be amplified in lotic ecosystems receiving effluents from wastewater treatment plants (WWTP). However, the impact of WWTPs on the microbial parameters of the urban river sediments has not been well documented compared to urban surface water. Collecting sediment samples at five different locations over a 9,000 m transect during four sampling periods, we investigated spatiotemporal variations of microbial parameters in sediments of lower Des Plaines River; the largest effluent-dominated stream in the United States and the effects of sediment physicochemical properties on the …

Microvascular Flow Imaging: A State-Of-The-Art Review Of Clinical Use And Promise., Muhammad Usman Aziz, John R Eisenbrey, Annamaria Deganello, Mohd Zahid, Kedar Sharbidre, Paul Sidhu, Michelle L Robbin

Department of Radiology Faculty Papers

Vascular imaging with color and power Doppler is a useful tool in the assessment of various disease processes. Assessment of blood flow, from infarction and ischemia to hyperemia, in organs, neoplasms, and vessels, is used in nearly every US investigation. Recent developments in this area are sensitive to small-vessel low velocity flow without use of intravenous contrast agents, known as microvascular flow imaging (MVFI). MVFI is more sensitive in detection of small vessels than color, power, and spectral Doppler, reducing the need for follow-up contrast-enhanced US (CEUS), CT, and MRI, except when arterial and venous wash-in and washout characteristics would …

Use Of High-Resolution Ultrasound To Guide Alcohol Neurolysis For Chronic Pain, Russell A. Reeves, Cole J. Miller, Dajie Wang, Andrew Ng, Joshua E. Heller, Levon N. Nazarian

Department of Radiology Faculty Papers

BACKGROUND: The diagnosis and treatment of neuropathic pain is often clinically challenging, with many patients requiring treatments beyond oral medications. To improve our percutaneous treatments, we established a clinical pathway that utilized ultrasound (US) guidance for steroid injection and alcohol ablation for patients with painful neuropathy.

OBJECTIVES: To describe a collaborative neuropathy treatment pathway developed by a neurosurgeon, pain physicians, and a sonologist, describing early clinical experiences and patient-reported outcomes.

STUDY DESIGN: A retrospective case series was performed.

METHODS: Patients that received percutaneous alcohol ablation with US guidance for neuropathy were identified through a retrospective review of a single provider's …

Cyclic Porewater Pressure Generation In Intact Silty Soils, Arash Khosravifar, Stephen Dickenson, Diane Moug

Civil and Environmental Engineering Faculty Publications and Presentations

The results of cyclic strain-controlled, constant volume direct simple shear (CDSS) tests and field shaking tests have been evaluated for intact, natural, low-plastic silts from six different fine-grained soils with 54%–100% fines content, 47%–83% silt content, and plasticity indices (PI) ranging from nonplastic to 16. These tests constitute a subset of a larger archive of CDSS tests performed on silt deposits from the Pacific Northwest, British Columbia, and Alaska collected and analyzed by the co-authors. The cyclic data are presented in this paper for two objectives: (a) to characterize cyclically-induced excess pore pressure generation in intermediate soils with various soil …

Reciprocating Our Marketing Powers: Academic And Public Library Partnerships, Mark Aaron Polger

Publications and Research

No abstract provided.

Cultural And Telehealth Considerations For Trauma-Focused Treatment Among Latinx Youth: Case Reports And Clinical Recommendations To Enhance Treatment Engagement, Andel V. Nicasio, Juventino Hernandez Rodriguez, Bianca T. Villalobos, Aubrey R. Dueweke, Michael A. De Arellano, Regan W. Stewart

Psychological Science Faculty Publications

Given that trauma exposure among youth, particularly those from communities of color, is high, there is a dire need to improve trauma-focused treatment for young people of color. Growing research has documented that integrating cultural and telehealth considerations into trauma-focused treatment can enhance treatment engagement and lead to positive treatment outcomes. Therefore, the purpose of this paper is to demonstrate how to incorporate cultural and telehealth considerations concurrently to enhance treatment engagement for Latinx youth and their caregivers. Specifically, we describe the process of delivering Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) to three trauma-exposed Latinx youths through the use of telehealth …

Abdominal Pain For Community Providers, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Cleft Palate Repair Enhanced Recovery After Surgery, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.