Digital Commons Network^™

Ashes, Cl Bledsoe

The Alembic

No abstract provided.

Student Stormwater Research Helping Keep Community Ecosystems Healthy, Keith Testa

Sustainability Institute Blog

No abstract provided.

Development Of A Multiplex Assay For Early Detection Of Pancreatic Cancer In High-Risk Groups, Sheng Pan, Ramesh Karki, Lisa A Lai, Chad J Creighton, Teresa A Brentnall, Randall E Brand, Ru Chen

Faculty, Staff and Student Publications

No abstract provided.

Faculty Senate Executive Committee Agenda (4/21/2026), Csusb Faculty Senate

CSUSB Faculty Senate records

No abstract provided.

Faculty Senate Executive Committee Minutes (4/21/2026), Csusb Faculty Senate

CSUSB Faculty Senate records

No abstract provided.

Morphology Extraction And Analysis Of Primary Soot Particles And Aggregates And Aggregates In Soot Tem Images Using Machine Learning, Timothy Paul Day

Master's Theses (2009 -)

Accurate characterization of soot morphology is crucial for understanding soot’s physical and chemical properties and their effects on climate and public health. Morphological characterization requires manual identification and segmentation of individual primary particles and aggregates, a labor-intensive and time-consuming process limits scale and reproducibility and contributes to uncertainty in climate models. Therefore, automated approaches are needed to reliably quantify soot morphology. This work develops SAGE (Soot Aggregate Geometry Extraction), an instance segmentation model and framework to segment primary particles in TEM images and extract morphological properties. Four key questions are addressed: (1) can the model achieve segmentation quality comparable to …

Building A Sustainable Framework For Pharmacy Resident Ce Programming, Heather Raeder

All Other Contributions

No abstract provided.

Development Of Telenutrition Education And Counseling Protocol To Improve Diet Quality In Individuals With Spinal Cord Injury, Adrianne Widaman, Benjamin Dirlikov, Ramya Gopalan, Shelley Wood, Maria Sol Casas, Kazuko Shem

Faculty Research, Scholarly, and Creative Activity

Background: Cardiometabolic disease (CMD) is a leading cause of death for individuals living with chronic spinal cord injury (SCI), with a mortality rate due to CMD being higher than individuals without SCI. Telenutrition (TN) interventions tailored to health and accessibility needs of individuals with SCI may mitigate cardiometabolic risks. Objectives: To describe the development and validation of a telehealth-based medical nutrition therapy (MNT) within a clinical trial investigating the effectiveness of modifying diets to improve cardiometabolic health in persons with chronic SCI. Methods: The adaptive module-based MNT education content was developed in 3 phases by a multidisciplinary team. The first …

Deep Learning Framework For Quantifying Self-Organization In Myxococcus Xanthus, Jiangguo Zhang, Eduardo A. Caro, Peiying Chen, Trosporsha Tasnim Khan, Patrick A. Murphy, Lawrence J. Shimkets, Ankit B. Patel, Roy D. Welch, Oleg A. Igoshin

Faculty Research, Scholarly, and Creative Activity

Under starvation, Myxococcus xanthus bacteria initiate a multicellular developmental program in which cells move to form fruiting bodies and differentiate into distinct cell types. Many genes affecting this process have been identified, and it is assumed that perturbing genes within the same pathway induces similar changes in the phenotype, although these changes may be subtle or obscured by pleiotropy. However, these pathways cannot be systematically mapped because there are no reliable methods for quantifying phenotype similarity. Here, we applied deep learning to quantify phenotype patterns and self-organization dynamics of 292 genetically distinct strains. We integrated ResNet and StyleGAN2 into a …

Cardiovascular Disease And Dyslipidemia In Pediatric Type 1 Diabetes, Grace K Kim, Preneet Cheema Brar, Nidhi Bansal

Faculty, Staff and Students Publications

Purpose of review

Despite advances in type 1 diabetes (T1D) management, mortality is still increased, with cardiovascular disease (CVD) as the leading cause. Dyslipidemia is a highly prevalent modifiable CVD risk factor. We reviewed the existing literature on CVD mortality in T1D to highlight CVD risk in pediatric patients with T1D.

Recent findings

Pathophysiology of T1D and premature CVD risk is still not fully understood. Dyslipidemia remains a highly prevalent and undertreated CV risk factor in T1D. Statins have been shown to be safe and effective to improve CVD risk in adults with T1D, and in children with familial hypercholesterolemia, …

Riverton Square, Llc V. Serigne

All Decisions

In a nonpayment proceeding, the landlord claimed the apartment was exempt from rent stabilization due to high rent vacancy deregulation. The tenant challenged this deregulation and the proper monthly rent. Citing inconsistencies in the apartment's rent history, including varying rent registrations and periods of no registration, the tenant moved for discovery into the regulatory status and legal regulated rent. The court found "ample need" for discovery due to these unexplained irregularities and granted the tenant's motion, directing the landlord to produce the requested information.

Tracey-Douglas V. Douglas

All Decisions

In a holdover proceeding, the tenant's motion to dismiss was granted due to the landlord's failure to properly serve the predicate 60-day notice. The purported substitute service was defective as it lacked proof of required mailings. Additionally, the landlord failed to comply with the Good Cause Eviction Law (GCEL) pleading requirements. Although claiming a "small landlord" exemption, the petition did not provide the statutorily mandated disclosures and contained contradictory allegations regarding the grounds for eviction. The court dismissed the petition against all respondents.

Obstructive Sleep Apnea Treatment Modifies The Effectiveness Of Catheter Ablation For Atrial Fibrillation: Post Hoc Analysis Of The Cabana Trial, Matthew W Segar, Kaleb D Lambeth, Brett Doliner, Joshua R Hirsch, Abdi Rasekh, Mehdi Razavi

Faculty, Staff and Students Publications

No abstract provided.

Rhesus Macaques With An Opa1 Mutation Demonstrate Features Of Autosomal Dominant Optic Atrophy, Tracy N Jaggers, Ana Ripolles-Garcia, Ala Moshiri, Brett D Story, Jun Wang, Rui Chen, Lucy G Moore, Leandro B C Teixeira, Jaeho Shim, Ana C Raposo, Maria Isabel Casanova, Sophie M Le, Sangwan Park, Laura J Young, Soohyun Kim, Karolina P Roszak, Vanessa Ureno, Paige M Karpinen, Nayeli Echeverria, Monica Ardon, Brian C Leonard, Marguerite Knipe, Eliza Bliss-Moreau, Brad Fortune, J Timothy Stout, Jeffrey Rogers, Nicholas Marsh-Armstrong, Sara M Thomasy

Faculty, Staff and Students Publications

Autosomal dominant optic atrophy (ADOA) is an inherited optic neuropathy primarily caused by mutations in OPA1. We identified and defined a spontaneous nonhuman primate (NHP) model of ADOA using rhesus macaques heterozygous for a missense mutation (OPA1A8S). With ocular examinations, ophthalmic imaging, electroretinography, histopathology, immunohistochemistry, and transmission electron microscopy (TEM), we documented retinal nerve fiber layer (RNFL) thinning, retinal ganglion cell (RGC) loss and dysfunction, OPA1 mislocalization, and reduced axonal mitochondrial density in affected macaques. Our investigation revealed substantial phenotypic variability among affected macaques, shedding light on the pathogenesis of ADOA. The retinas were evaluated using techniques …

Model Unification: A Systematic Approach For The Cluster Expansion, Kolten Barfuss

Theses and Dissertations

A systematic approach for model unification of cluster expansion models is developed and demonstrated. The method builds on previous work with the Manifold Boundary Approximation Method (MBAM) to identify supremal models. The work is motivated by the exercise of unifying cluster expansion models – characterized by Π matrices – for two binary alloys that share one atomic species to form a model for the ternary alloy. The result is the Supremal Π Algorithm, a systematic unification algorithm that relies on an MBAM-informed understanding of models and on the singular value decomposition. The algorithm yields ΠΛ, a Π matrix for the …

Deep Learning And Experimental Validation Of Brca1-Associated Protein-1 Missense Variant Pathogenicity In Uveal Melanoma, Nikhil Davé, David J. Taylor Gonzalez, Mak B. Djulbegovic, Linda A. Cernichiaro-Espinosa, Benjamin A. King, Carol L. Shields, Matthew W. Wilson

Wills Eye Hospital Papers

OBJECTIVE: To benchmark the pathogenicity predictions of AlphaMissense, a deep learning model, against high-throughput functional scores from saturation genome editing (SGE) for all experimentally tested BRCA1-associated protein-1 (BAP1) missense variants in uveal melanoma (UM).

DESIGN: Cross-sectional analytical study comparing computational predictions with experimentally derived functional classifications and clinical annotations.

SUBJECTS PARTICIPANTS AND/OR CONTROLS:  ClusteredAll 4619 BAP1 single amino acid substitutions profiled in a published Regularly Interspaced Short Palindromic Repeats-Cas9 SGE viability assay. No separate control cohort was required. Clinical Variant Database (ClinVar)-annotated variants within this set served as an independent reference.

METHODS: Saturation genome editing log₂-fitness …

Teacher Voices In Ethnic Studies: Bridging Policy And Practice Through Educator Insights In California, Isiah Peter Iniguez

LMU Theses and Dissertations

This study explores ethnic studies teachers’ perceptions of implementing ethnic studies as a required course in California. This study used both critical pedagogy (Freire , 1970) and pedagogical content knowledge (PCK; Shulman, 1986) as theoretical frameworks. Through interviews with thirteen ethnic studies teachers across California, this research uncovered the pedagogical demands, implementation challenges, and transformative potential of ethnic studies education. The findings illuminated a fundamental tension between ethnic studies’ community-centered nature and pressures toward standardization. Teachers emphasized that ethnic studies had to be rooted in community, describing powerful outcomes when the curriculum reflected students’ identities, local histories, and lived experiences. …

What's The Scoop On Life In New Hampshire? Youth Perspectives On New Hampshire As A Place To Live, Learn, And Work After High School, Elliot Ng, Jayson Seaman, Cindy L. Hartman, Andrew D. Coppens, Kate Moscouver, Hannah Falcone

Carsey Publications

To support its long-term economic vitality, New Hampshire must cultivate and retain its young talent. This brief analyzes the perspectives of New Hampshire youth and proposes actionable strategies that encourage them to build their futures in the state. While a majority of New Hampshire youth leave the state after high school, retention opportunities lie in leveraging what youth already love about the Granite State: Its natural environment, abundant outdoor amenities, and safe communities. By leveraging these assets and complementary policies such as expanding career-connected learning, promoting the abundance of in-state opportunities, and developing centralized social spaces, New Hampshire can create …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Unusual Rna Polymerase Ii Patterns In Meiotic Prophase I In Nannospalax Xanthodon: Insights Into Chromatin, Telomeres, And Sex Chromosomes, Sergey N. Matveevsky, Ferhat Matur, Faruk Çolak, Andrei Kandaurov, Mustafa Sözen, Svetlana V. Pavlova, Oxana Kolomiets

Turkish Journal of Biology

Background: Meiotic transcription is a highly regulated process involving stage-specific chromatin remodeling and dynamic RNA polymerase II (RNAPII) activity. Nevertheless, our current understanding is largely based on classical model organisms, while many nonmodel mammals remain unexplored. This study investigates the transcriptional dynamics and chromatin features during meiotic prophase I in Nannospalax xanthodon, a subterranean blind mole rat species with extensive intraspecific karyotype variation.Materials and methods: Using immunofluorescence, we analyzed synapsis and transcriptional activity in spermatocyte nuclei of two geographically distant N. xanthodon males, detecting SYCP3, CREST, γH2AFX, and phosphorylated RNAPII (Ser5, Ser2). Telomereassociated proteins RAP1 and TERT were also examined …

Protective Effect Of Pinocembrin On Zearalenone-Induced Hepatotoxicity Via Pi3k/Akt And Nrf2 Signaling In Albino Mice, Sujatha Tejavat

Turkish Journal of Biology

Background/aim: Zearalenone (ZEA) is a Fusarium-derived mycotoxin that frequently contaminates food and feed and induces hepatotoxicity in humans and animals through oxidative stress and inflammation. Pinocembrin (PCM), a naturally occurring flavonoid, has potent antioxidant and antiinflammatory properties. This study investigated the hepatoprotective effects of PCM against ZEAinduced liver injury in albino mice, with a focus on the nuclear factor erythroid 2–related factor 2 (NRF2) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathways. Materials and methods: Twenty-four albino male mice were allocated into four groups: (1) control (vehicle 0.05% dimethyl sulfoxide), (2) ZEA-treated (40 mg/kg body weight), (3) PCM-treated (50 mg/kg …

Single-Walled Carbon Nanotube-Mediated Plasmid Dna Delivery In The Model Monocot Brachypodium Distachyon, Kaya İşleyen Bi̇lge, Bahar Soğutmaz Özdemi̇r

Turkish Journal of Biology

Background/aim: Plant genetic engineering is a valuable approach for improving stress tolerance, crop productivity, and quality traits. However, its progress is limited by the drawbacks of traditional transformation methods. Commonly used techniques, such as Agrobacterium-mediated transformation and biolistics, are restricted by genotype dependency, lengthy tissue culture steps, and low efficiency, particularly in monocot species. Therefore, the development of alternative gene delivery strategies remains an ongoing research focus in plant biotechnology. Nanoparticle-based delivery systems have recently gained attention due to their physiochemical properties, biocompatibility, and potential for alternative gene delivery approaches in plant systems.Materials and methods: We investigated the use of …

Modulating Microtubule Stability Via Α-Tubulin Acetylation Partially Restores Golgi Fragmentation In Spinal Muscular Atrophy, Peli̇n Zobaroğlu Özer, Memet Gözüböyük, Özge Çeti̇n, Niko Hensel, Güzi̇n Emecen, Adam Malik, Melissa Bowerman, Peter Claus, Hayat Erdem Yurter, Gamze Bora Akoğlu

Turkish Journal of Biology

Background/aim: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of survival of motor neuron (SMN) protein. SMN deficiency leads to perturbations of the cytoskeleton, including microtubules, which are mainly involved in motilityrelated cellular processes. However, the molecular mechanisms of microtubule dysregulation in SMA remain elusive. Alpha (α)-tubulin is a structural component of microtubules, and its posttranslational modifications affect microtubule dynamics. Here, we aimed to investigate α-tubulin acetylation and related molecular mechanisms in SMA. Materials and methods: Two different SMA mouse models, the Drosophila melanogaster model and patient-derived fibroblasts, were used in the study. Western blot and …

Combinatorial Effect Of Epirubicin And 5-Fluorouracil In The Treatment Of Temozolomide-Resistant Glioblastoma Cells, Mehrsa Bayat, Muhli̇s Akman, Türker Kiliç, Ti̇muçi̇n Avşar

Turkish Journal of Biology

Background: Glioblastoma (GBM) is a highly aggressive form of brain tumor characterized by rapid proliferation and invasiveness. It is associated with a poor prognosis due to acquired resistance to temozolomide (TMZ). In this study, we investigated whether a combination of epirubicin, 5-fluorouracil (5-FU), and TMZ could improve TMZ sensitivity in resistant GBM cells and help overcome resistance.Materials and methods: TMZ resistance was established in the U87MG cell line. The MTT assay was used to measure cell viability. Reactive oxygen species (ROS) and apoptosis were measured using flow cytometry. RNA-seq was used to evaluate genomic changes based on treatment with drugs …

Perceived Inadequate Neighborhood Food Shopping And Cardiovascular Disease Risk: The Multi-Ethnic Study Of Atherosclerosis, Amier Haidar, Ghadi Ghanem, Rishi Rikhi, Karol E Watson, Shreela V Sharma, Michael D Shapiro

Faculty, Staff and Student Publications

Background: Individuals with access to healthy food have healthier diets, improved cardiometabolic risk profiles, and decreased cardiovascular disease (CVD). However, previous studies have focused on the neighborhood food environment as distance to and density of food retailers. Our study examines the association between an individual's perceived adequacy of neighborhood food shopping and incident CVD.

Methods: We analyzed data from 6814 participants in the MESA (Multi-Ethnic Study of Atherosclerosis), a prospective cohort study of individuals aged 45 to 84 who were enrolled in the study between 2000 and 2002 and followed longitudinally. Cox proportional hazards models estimated hazard ratios (HRs) for …

The Impact Of Cannabis Use On Pulmonary Function Among Young Adults: A Literature Review, Ava Petersen

Honors Theses

Cannabis is the most used illicit drug among young adults and many of these users perceive cannabis as harmless and do not believe the drug to be addictive. Cannabis is derived from the flower of the hemp plant and contains cannabinoids THC (tetrahydrocannabinol) and CBD (cannabidiol). THC is the psychoactive component that interacts with the endocannabinoid system to produce a coveted euphoric state among users. Cannabis can be consumed in an edible or combusted and inhaled via joint, pipe, bong, etc. The purpose of this review is to examine the effects of inhaled cannabis on pulmonary function with a specific …

Losing The Loop: Iteratively Autonomous Artificial Intelligence And The Question Of Human Operational Involvement, Elise Annett, James Giordano

Strategic Insights

As AI systems evolve from analytic tools to iteratively autonomous systems, they assume greater roles in filtering information, structuring decision pathways, and shaping operational outcomes. This transition alters human involvement, moving operators from direct decision-makers to supervisors, while distributing authority across designers, commanders, and operators. Growing reliance on AI introduces cognitive and behavioral shifts, including reduced critical scrutiny and increased dependence on machine-generated outputs. These dynamics can create self-reinforcing decision loops in which AI-generated data and assessments are recursively validated without sufficient grounding in real-world conditions. Such conditions risk obscuring attribution, degrading command and control, and increasing the likelihood of …

Functional Requirement For Dicer Helicase Arginine Methylation In 26 G Sirna Biogenesis And Oocyte Meiotic Program, Nick Newkirk, Shin-Yu Chen, Tokiko Furuta, Kenneth A Trimmer, Leilei Shi, Sabrina Stratton, Hongyuan Li, Xiaodong Cheng, Mark T Bedford, Swathi Arur

The Brown Foundation: Institute of Molecular Medicine

Spatiotemporal regulation of Dicer is essential for small RNA biogenesis and fertility, yet how its helicase domain is controlled remains unclear. Using Caenorhabditis elegans, we identify a regulatory role for the arginine-rich GRARR motif within helicase domain motif VI of DCR-1. Mutating conserved arginines in this sequence disrupts maternal 26 G endo-siRNA production, impairs oocyte meiosis I and II, and reduces fertility. Biochemically, an asymmetrically dimethylated DCR-1 GRA[R495*]R peptide enhances interaction with ERI-5, a tandem-Tudor protein in the ERIC complex, while loss of DCR-1(R495) diminishes this interaction in vivo. Genetically, eri-5 deletion phenocopies the dcr-1 R495K mutant, supporting a functional …

Mild Thermal Treatment Of Lithium-Ion Batteries To Optimize Black Mass Production, Brooke Lillie

Theses and Dissertations

This thesis explains the design of equipment and the experimental procedure for thermal treatment of lithium-ion batteries for the purpose of low-cost materials recycling. Conditions used were between 150 ℃ and 425 ℃, involving different atmospheric conditions and treatment durations. The battery samples were processed through a sieve shaker device. Mass loss during the heat treatment, and separation of the battery through sieving was used to analyze the effect of the treatments on separability of black mass from the batteries. Additionally, internal battery temperature was measured and compared to real average furnace temperature to monitor thermal runaway. Testing showed minimal …

The Artificial Maintenance Of Relationship Satisfaction: Romantic Ai Companion Usage Sustains Emerging Adults' Human Romantic Relationship Satisfaction While Eroding Relationship Stability, Rebekah M. Hakala

Theses and Dissertations

As artificial intelligence becomes increasingly sophisticated, romantic AI companions--AI systems designed to simulate romantic, emotional, or sexual relationships--have emerged as a novel relational phenomenon. Nearly one in four emerging adults now engage with romantic AI companions, yet little is known about how this usage affects their romantic human relationships. Drawing on Social Exchange Theory and the Investment Model of Commitment, and employing structural equation modeling, this thesis uses data from 2,431 emerging adults in romantic relationships to examine whether romantic AI companion usage influences relationship satisfaction and relationship stability among emerging adults in the United States (ages 18-30), and whether …