Digital Commons Network^™

Feasibility Of [18f]Fspg Pet For Early Response Assessment To Combined Blockade Of Egfr And Glutamine Metabolism In Wild-Type Kras Colorectal Cancer, Seong-Woo Bae, Jianbo Wang, Dimitra K Georgiou, Xiaoxia Wen, Allison S Cohen, Mohammed Noor Tantawy

Faculty, Staff and Student Publications

Early response assessment is critical for personalizing cancer therapy. Emerging therapeutic regimens with encouraging results in the wild-type (WT) KRAS colorectal cancer (CRC) setting include inhibitors of epidermal growth factor receptor (EGFR) and glutaminolysis. Towards predicting clinical outcome, this preclinical study evaluated non-invasive positron emission tomography (PET) with (4S)-4-(3-[18F]fluoropropyl)-L-glutamic acid ([18F]FSPG) in treatment-sensitive and treatment-resistant WT KRAS CRC patient-derived xenografts (PDXs). Tumor-bearing mice were imaged with [18F]FSPG PET before and one week following the initiation of treatment with either EGFR-targeted monoclonal antibody (mAb) therapy, glutaminase inhibitor therapy, or the combination. Imaging was correlated with tumor volume and histology. In PDX …

Monitoring Resistance And Biochemical Studies Of Three Egyptian Field Strains Of Spodoptera Littoralis (Lepidoptera: Noctuidae) To Six Insecticides, Moataz A M Moustafa, Rasha I A Moteleb, Yehia F Ghoneim, Sameh Sh Hafez, Reham E Ali, Nancy N Hassan

Faculty, Staff and Student Publications

BACKGROUND:

METHODS: Laboratory bioassays were carried out using the leaf-dipping method to examine the susceptibility of the laboratory and field strains to the tested insecticides. Activities of detoxification enzymes were determined in an attempt to identify resistance mechanisms.

RESULTS: The results showed that LC

CONCLUSION: Our findings, along with other tactics, are expected to help with the resistance management of

“From This Invisible Archipelago”: The Oceanic Ecopoetics Of Craig Santos Perez, Mandy Bloomfield

School of Law, Humanities and Social Sciences

No abstract provided.

Patient And Therapeutic Radiographer Experiences Of Comfort During The Radiotherapy Pathway: A Qualitative Study, Simon Goldsworthy, Jos M. Latour, Shea Palmer, Helen A. Mcnair, Mary Cramp

School of Nursing and Midwifery

Introduction There is little research regarding the experiences of patient comfort and how it is best managed in radiotherapy. The aim of this study was to explore the experiences of patient and therapeutic radiographer views of comfort during radiotherapy. Methods This qualitative study involved semi-structured interviews, with cancer patients (n=25) and therapeutic radiographers (n=25), conducted between January-July 2019. Patients were recruited from one radiotherapy clinic and therapeutic radiographers were recruited from across the United Kingdom via specialist interest groups and social media. Interviews were audio-recorded and transcribed verbatim. Thematic analysis was used to analyse the data separately between both groups …

Multitrait Genome-Wide Analyses Identify New Susceptibility Loci And Candidate Drugs To Primary Sclerosing Cholangitis, Ryan Sun, Julia Y Roh, Heather J Cordell, Hyun-Sung Lee, Vikram R Shaw, Sung Wook Kang, Javad Razjouyan, Matthew A Cooley, Manal M Hassan, Katherine A Siminovitch, Trine Folseraas, David Ellinghaus, Annika Bergquist, Simon M Rushbrook, Andre Franke, Tom H Karlsen, Konstantinos N Lazaridis, Kathryn A. Mcglynn, Katherine A Mcglynn, Lewis R Roberts, Christopher I Amos, International Psc Study Group

Faculty, Staff and Students Publications

Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly associated with immune-mediated disorders. In this study, we implemented multitrait joint analyses to genome-wide association summary statistics of PSC and numerous clinical and epidemiological traits to estimate the genetic contribution of each trait and genetic correlations between traits and to identify new lead PSC risk-associated loci. We identified seven new loci that have not been previously reported and one new independent lead variant in the previously reported locus. Functional annotation and fine-mapping nominated several potential susceptibility genes such as MANBA and IRF5. Network-based in silico drug …

50th Anniversary Of Kitlv-Jakarta, Marrik Bellen

Wacana, Journal of the Humanities of Indonesia

No abstract provided.

Foreword, Adrianus L.G. Waworuntu

Wacana, Journal of the Humanities of Indonesia

No abstract provided.

Design Power And Potential Future Of Global Organization Of Life, A. Fuat Fırat

Markets, Globalization & Development Review

In this essay I propose a definition of design to address its potential role in largely determining power relations in the future. Some foundational discussion of wealth, culturally constructed differently in different historical times, trends of corporatization in the contemporary world, and the birth of control society is presented to help understand the possibilities and difficulties of building future organizations of life. I invite discussions and dialogues to widen and deepen the concept of design power.

An Institutional Perspective On Climate Change, Markets, And Consumption Across Three Countries, Delphine Godefroit-Winkel

Markets, Globalization & Development Review

This manuscript enriches knowledge about consumers’ responses to climate change actions. Through the lens of institutional theory, it examines the findings of three studies run in France, Morocco and the United States. In Morocco, consumers are more responsive to climate change actions when they are managed at the level of their country, and company. Moroccan consumers express ambivalent emotions when their supermarket engages in actions to combat climate change. In France, consumers are less responsive when their country engage in climate change actions, but they display positive responses towards their supermarkets’ climate change actions. In the United States, the responses …

Marketing, Development, And The Question Of Meaning, Dominique Bouchet

Markets, Globalization & Development Review

Originally developed as a sales technique, marketing ended up playing an economic and political role globally. With the advent of globalization and sustainability issues, the importance given to the techniques of marketing in both analyses and in communication limits the possibility of mutual understanding and of social creativity. A profound understanding of what is at stake for society and culture is not what matters when the focus is on the ways to maintain the superficial link to the instrument of power.

The market plays a central role within the fields of marketing, economics and politics. Yet, questions of what the …

Privileging Localism And Visualizing Nationhood In Anti-Consumption, Rohit Varman, Russell Belk

Markets, Globalization & Development Review

The main aim of this research is to understand the genesis and nature of an anti-consumption movement in India and its emphasis on nationalism through localism. This research adopted a case study design, including in-depth interviews and discursive analysis. Through a historical analysis this research shows the influence of anarchist political philosophy in a contemporary anti-consumption movement. It demonstrates that anti-consumption is inflected with discourses of freedom, anti-authoritarianism, and anti-statism, which are central to the anarchist conception of localism. This research shows that anti-consumption movements in India use consumption objects to privilege local over both national and international. This helps …

Establishing Meaning And Values In Marketing And Broadening Perspectives In Understanding Nationhood And Climate Change, Deniz Atik, Nikhilesh Dholakia

Markets, Globalization & Development Review

No abstract provided.

Pasture Land Management System Decision Support Software, G. E. Groover, S. R. Smith, N. D. Stone, J. J. Venuto, J. M. Galbraith

IGC Proceedings (1977-2023)

Controlled or rotational grazing provides benefits to producers and society through profitable and sound management of grazing land and livestock. Pasture land management system (PLMS) is a decision support system developed to help university, government, and professionals provide technical pasture management assistance to beef and dairy producers. The PLMS focuses on the balance between seasonal forage supply and nutrient demand in a dairy or beef cattle operation. It allows users to explore and compare alternatives (dividing fields into multiple paddocks, changing stocking rates, and forage species) through a visual display and embedded simulation. Users enter a description of the farm …

Forecast Of Herbage Production Under Continuous Grazing, K. Søegaard, J. Berntsen, K. A. Nielsen, I. Thysen

IGC Proceedings (1977-2023)

The utilization of pasture is very sensitive to oscillations in herbage growth. The farmer’s daily planning involves decisions on pasture use as well as on the amount and composition of supplement feeding. In this planning, expected daily growth rate is an important factor. Often the knowledge and experience about the growth rate is first available after changes in management should have been made. A different growth rate than expected should lead to changes in the grazing area or in the supplement feeding. Therefore, a simple model of grass/clover growth under grazing and irrigated conditions was developed. From spring 2004, the …

A Decision Support Tool For Seed Mixture Calculations, B. P. Berg, G. Hutton

IGC Proceedings (1977-2023)

Grassland species are normally seeded in mixtures rather than monocultures. In theory, seeding rates for mixtures are simply a sum of the amount of pure live seed (PLS) of each seed lot in the mix, an amount sufficient to ensure establishment and survival of each species. Mixtures can be complex because of the number of species used (especially in conservation and reclamation programs) and variations in seed purity and seed size. Soil limitations and seeding equipment settings need to be considered and in Canada, a metric conversion may be required. All these conditions make by-hand calculations of mixtures containing more …

Risk-Efficiency Assessment Of Haying, A. J. Romera, J. Hodgson, S. T. Morris, S. J. R. Woodward, W. D. Stirling

IGC Proceedings (1977-2023)

Pastoral livestock farms are complex, dynamic systems subject to many forms of external disturbance. Farm Management strategies are therefore typically designed to minimize system variation. The objective of this study was to explore the impacts of different haying policies, in terms of expected profit and risk, for cow-calf farms in the Salado Region of Argentina.

Environmental Clustering Of New Zealand Dairy Herds, J. R. Bryant, N. López-Villalobos, J. E. Pryce, C. W. Holmes

IGC Proceedings (1977-2023)

Previous studies have found that milk yield (a proxy for feeding level) and temperature-humidity index (THI) are important factors in explaining genotype x environment (G x E) interactions, indicating differences between the abilities of genotypes to forage or consume concentrates effectively or to cope with thermal stress (Ravagnolo and Misztal, 2000; Zwald et al., 2003). The objective of this study was to quantify and cluster (CL) herd environments within New Zealand (NZ) based on production levels, a summer heat load index (HLI) and geographical location.

Irish Dairy Farming: Effects Of Introducing A Maize Component On Grassland Management Over The Next 50 Years, A. J. Brereton, N. M. Holden

IGC Proceedings (1977-2023)

Typical management of Irish dairy units is based on a low-cost spring-calving strategy with 90% of annual feed derived from grass grown on the farm. Almost 70% of feed is from grazed grass managed by rotational grazing, the remainder is conserved forage and concentrates. The objectives of the work were to examine how the management system has to be modified when part of the dairy unit land is allocated to maize silage instead of grass silage production, and to examine how climate change over the next 50 years will impact on grass and maize management within the production system.

Autumn Root Reserves Of Lucerne Affected Shoot Yields During The Following Spring, D. J. Moot, E. I. Teixeira

IGC Proceedings (1977-2023)

Frequent grazing affects shoot yield of lucerne (Medicago sativa L.) by limiting radiation interception (Teixeira et al., 2005b) and the accumulation of endogenous reserves (C and N) in perennial storage organs like crowns and taproots (Teixeira et al., 2005a). In temperate regions, the impact of low level of perennial reserves is particularly evident during early-spring, when lucerne regrowth resumes after an overwintering period. The analysis of lucerne yield can be fragmented into its yield components of plant population, shoots per plant and yield per shoot (Volenec et al., 1987). The objective of this research was to quantify …

Lucerne Crown And Taproot Biomass Affected Early-Spring Canopy Expansion, E. I. Teixeira, D. J. Moot, A. L. Fletcher

IGC Proceedings (1977-2023)

Leaf area index (LAI) quantifies canopy expansion in crops and is used in lucerne (Medicago sativa L.) simulation models to predict daily PAR interception (PAR i). This then drives yield through radiation use efficiency (RUE) (Gosse et al., 1984). In perennial crops, like lucerne, the level of biomass stored in crown and taproot may affect canopy expansion in subsequent regrowth cycles (Avice et al., 1997). In temperate regions the impact of this is likely to be greatest in early-spring, when low temperatures delay development. The objective of the current research was to identify whether contrasting levels of winter biomass in …

Extending The Grazing Season With Turnips, P. Thomet, S. Kohler

IGC Proceedings (1977-2023)

A comparison of the actual feeding costs on 86 typical Swiss dairy farms confirmed that the production of hay and grass silage is very expensive with costs from the field to intake in the range of 20-25 Euro cents/kg of dry matter (DM). Options to extend the grazing season for dairy cows in the late autumn and early winter, and hence reduce winter feeding costs, would therefore be welcome (Penrose et al., 1996). The aim of the study was to compare the DM production potential of summer-seeded turnips with other brassicas and Italian ryegrass and to test whether dairy cows …

Milk Production Performance Based On Grazed Grassland In Switzerland, P. Thomet, H. Menzi

IGC Proceedings (1977-2023)

A common feature of profitable dairy systems is the use of large amounts of low cost feed. One approach to improve the competitive ability of the dairy production therefore is to promote grazing (Dillon et al., 1995). A comparison of the actual feeding costs on typical Swiss dairy farms showed that hay and grass silage were four times and concentrates seven times more expensive than grazed grass. A maximum utilisation of grazed grass can be achieved with a seasonal production system, which synchronises the cow’s feed requirements with pasture growth. This strategy was implemented and consistently optimised on an …

The Effect Of Inclusion Of A Range Of Supplementary Feeds On Herbage Intake, Total Dry Matter Intake And Substitution Rate In Grazing Dairy Cows, S. J. Morrison, D. C. Patterson, S. Dawson, C. P. Ferris

IGC Proceedings (1977-2023)

The milk production potential of dairy cows has increased substantially over the past two decades. This development presents new challenges for managing dairy cows during grazing, particularly where the objective is to maximise the proportion of energy in the diet derived from forage. The objective of the current study was to explore supplementation strategies to maintain high total forage intakes from grazed grass supplemented with alternative forage supplements in dairy cows during the grazing season. A second objective of the study was to examine the effect of supplement on substitution rate (SR) and milk yield response.

White Clover Soil Fatigue: An Establishment Problem On Large And Intensive Dairy Farms, K. Søegaard, K. Møller

IGC Proceedings (1977-2023)

In recent years a new constraint, clover soil fatigue, has appeared for the establishment of white clover (Trifolium repens) in Denmark. Increasing dairy farm size has led to more intensive use of clover in crop rotation schemes in the grazing areas located at convenient distances from stables. It has become common practice to establish new clover/grass in the fields just after ploughing clover/grass swards, and soil fatigue is becoming more common. On fatigued land the clover plants emerge, then become stunted and eventually disappear within the same year. The problem tends to cover the full field area. Obviously, …

Loving Blackness: A Sense Experience, Ricardo J. Millhouse

Feminist Pedagogy

The late bell hooks framed feminist pedagogies as a set of practices and systems that provide a description of feminism, a feminist learning environment, and ways to cultivate a community that is ready for feminist instruction. Using intersectionality, hooks (1992) discussed “loving blackness” as a representational and destabilizing practice to de-center whiteness. hooks (1992, 20) writes, “loving blackness as a political resistance transforms our ways of looking and being, and thus creates conditions necessary for us to move against the forces of domination and death and reclaim black life.” I propose a black feminist praxis teaching tool, “a sense experience,” …

Academic Spaces Of Possibility? A Proleptic Dialogue With Blackfeminism At The Center, Liliana Herakova, Lauren O. Babb, Kevin Roberge

Feminist Pedagogy

This critical commentary engages our experiences as co-educators in a “Black Feminist Thought and Expression” (BFTE) course, first-of-its-kind at our predominantly white institution in the U.S.. We imagine and provoke redefinitions of “classrooms” and “students” toward the liberatory dialogic learning bell hooks continues to inspire. We reflect on the potentials and perils of BFTE as pedagogical moves toward 1) becoming learners over and over again and 2) creating multiple different learning spaces, not confined to the physical classroom or to texts-as-usual. By bringing our beings together in both this essay and in BFTE, we re-member the dialogic pedagogy of love-as-action …

‘Reading The Cultural Landscape’ In The ‘Birthplace’ Of Modern Race/Racism: Using Hooks To Invite Students In As Critical Knowledge Producers & Co-Conspirators, Danielle Docka-Filipek

Feminist Pedagogy

No abstract provided.

Black Feminist Pedagogy In White Southern Spaces, Frances B. Henderson

Feminist Pedagogy

In Teaching to Transgress, bell hooks situates the classroom as “the most radical space of opportunity in academia” (hooks 1994,), as it is within this space that we might challenge and transcend ways of knowing centered in patriarchy, sexism and racism. But what happens when the classroom is located in spaces loyal to the historical frameworks that buttress white supremacist heteropatriarchy? This article examines my twelve years of experience in teaching undergraduate courses in political science at a small liberal arts college in the mid-South. At its center are critical reflections on attempts to formulate and employ a black feminist …

Ungrading As Feminist Praxis, Jessica L. Furgerson

Feminist Pedagogy

No abstract provided.

How I Learned To Love Teaching: Bell Hooks And The Possibilities Of The Feminist Classroom, Patti Duncan

Feminist Pedagogy

In this critical commentary, I describe the influence bell hooks has had on my pedagogy since first reading her book, Teaching to Transgress: Education as the Practice of Freedom, when I was a graduate student in Women’s and Gender Studies in the 1990s. The profound influence hooks’ work had on me, as a first generation, woman of color scholar from a working-class background, cannot be overstated. Her words helped me name and begin to critique and resist the isolation, alienation, and oppressive systems that had, up to that point, shaped my experience and the experience of many women of color …