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Articles 585721 - 585750 of 5207274
Full-Text Articles in Entire DC Network
High School Choral Festival (2023), St. Norbert College Music Department
High School Choral Festival (2023), St. Norbert College Music Department
Music Performances
SNC Music Department presents: the High School Choral Festival (2023).
Volume Cxlii, Number 15, February 24, 2023, Lawrence University
Volume Cxlii, Number 15, February 24, 2023, Lawrence University
The Lawrentian
No abstract provided.
Uab Received More Than $332 Million In Research Funding From The National Institutes Of Health In 2022, Alicia Rohan
Uab Received More Than $332 Million In Research Funding From The National Institutes Of Health In 2022, Alicia Rohan
Browse All News
No abstract provided.
Molecular Diagnostics In The Evaluation Of Thyroid Nodules: Current Use And Prospective Opportunities, Jena Patel, Joshua Klopper, Elizabeth E. Cottrill
Molecular Diagnostics In The Evaluation Of Thyroid Nodules: Current Use And Prospective Opportunities, Jena Patel, Joshua Klopper, Elizabeth E. Cottrill
Department of Otolaryngology - Head and Neck Surgery Faculty Papers
Thyroid cancer is the most common endocrine malignancy with an estimated 43,800 new cases to be diagnosed in 2022 and representing the 7th most common cancer in women. While thyroid nodules are very common, being identified in over 60% of randomly selected adults, only 5-15% of thyroid nodules harbor thyroid malignancy. Therefore, it is incumbent upon physicians to detect and treat thyroid malignancies as is clinically appropriate and avoid unnecessary invasive procedures in patients with benign asymptomatic lesions. Over the last 15-20 years, rapid advances have been made in cytomolecular testing to aid in thyroid nodule management. Initially, indeterminate thyroid …
Field-Tunable Berezinskii-Kosterlitz-Thouless Correlations In A Heisenberg Magnet, D. Opherden, M.S.J. Tepaske, F. Bärtl, M. Weber, M.M Turnbull, T. Lancaster, S.J. Blundell, M. Baenitz, J. Wosnitza, C.P. Landee, R. Moessner, D.J. Luitz
Field-Tunable Berezinskii-Kosterlitz-Thouless Correlations In A Heisenberg Magnet, D. Opherden, M.S.J. Tepaske, F. Bärtl, M. Weber, M.M Turnbull, T. Lancaster, S.J. Blundell, M. Baenitz, J. Wosnitza, C.P. Landee, R. Moessner, D.J. Luitz
Chemistry
We report the manifestation of field-induced Berezinskii-Kosterlitz-Thouless (BKT) correlations in the weakly coupled spin-1/2 Heisenberg layers of the molecular-based bulk material [Cu(pz)2(2-HOpy)2](PF6)2. At zero field, a transition to long-range order occurs at 1.38 K, caused by a weak intrinsic easy-plane anisotropy and an interlayer exchange of J′/kB≈1 mK. Because of the moderate intralayer exchange coupling of J/kB=6.8 K, the application of laboratory magnetic fields induces a substantial XY anisotropy of the spin correlations. Crucially, this provides a significant BKT regime, as the tiny interlayer exchange J′ only induces 3D correlations upon close approach to the BKT transition with its exponential …
Who Cares For The Young Carers?, R. Witton, A. Nelder
Who Cares For The Young Carers?, R. Witton, A. Nelder
Peninsula Dental School
No abstract provided.
Spring Awakening (2023) | Program, Jacksonville State University
Spring Awakening (2023) | Program, Jacksonville State University
Department of Theatre & Film Performance Archive
Performed: 24-27 February 2023; "Spring Awakening" was based on the play by Frank Wedeking, book and lyrics by Steven Sater, and music and orchestrations by Duncan Sheik. The rock musical explores the journey from adolescence to adulthood. The director was Carolyn Conover, choreographer was Alison Woodward, music director was Michael Greenwood, fight and intimacy choreographer was Bridget McCarthy, scenic designer was Jason St. John, costume designer was Freddy Clements, lighting designer was Jenn Luck, make up designers were Freddy Clements and Addie Lot, sound designer was John A. Davis, conductor was Jacob Moorer, fight/dance/intimacy captains were Semaje Newton and Erin …
Diversity Concert: Historically And Systemically Underrepresented, Marginalized, And Silenced Communities, February 24, 2023, Illinois State University School Of Music
Diversity Concert: Historically And Systemically Underrepresented, Marginalized, And Silenced Communities, February 24, 2023, Illinois State University School Of Music
School of Music Programs
Kemp Recital Hall
February 24, 2023
Friday Evening
7:00 pm
Artificial Intelligence-Based Chatbots For Promoting Health Behavioral Changes: Systematic Review, Abhishek Aggarwal, Cheuk Chi Tam, Dezhi Wu, Xiaoming Li, Shan Qiao
Artificial Intelligence-Based Chatbots For Promoting Health Behavioral Changes: Systematic Review, Abhishek Aggarwal, Cheuk Chi Tam, Dezhi Wu, Xiaoming Li, Shan Qiao
Publications
BACKGROUND: Artificial intelligence (AI)-based chatbots can offer personalized, engaging, and on-demand health promotion interventions. OBJECTIVE: The aim of this systematic review was to evaluate the feasibility, efficacy, and intervention characteristics of AI chatbots for promoting health behavior change. METHODS: A comprehensive search was conducted in 7 bibliographic databases (PubMed, IEEE Xplore, ACM Digital Library, PsycINFO, Web of Science, Embase, and JMIR publications) for empirical articles published from 1980 to 2022 that evaluated the feasibility or efficacy of AI chatbots for behavior change. The screening, extraction, and analysis of the identified articles were performed by following the PRISMA (Preferred Reporting Items …
Detection And Characterization Of Constitutive Replication Origins Defined By Dna Polymerase Epsilon, Roman Jaksik, David A Wheeler, Marek Kimmel
Detection And Characterization Of Constitutive Replication Origins Defined By Dna Polymerase Epsilon, Roman Jaksik, David A Wheeler, Marek Kimmel
Center for Medical Ethics and Health Policy Staff Publications
Background: Despite the process of DNA replication being mechanistically highly conserved, the location of origins of replication (ORI) may vary from one tissue to the next, or between rounds of replication in eukaryotes, suggesting flexibility in the choice of locations to initiate replication. Lists of human ORI therefore vary widely in number and location, and there are currently no methods available to compare them. Here, we propose a method of detection of ORI based on somatic mutation patterns generated by the mutator phenotype of damaged DNA polymerase epsilon (POLE).
Results: We report the genome-wide localization of constitutive ORI in POLE-mutated …
“It's Important To Talk About These Issues”: The Need For Leaders To Establish Connections And Address Students' Experiences And Concerns, Elizabeth Gil
GSE Faculty Publications
In this Conversations in Urban Education, high school student leader Sofia Díaz shares her experience with racial and gender inequity and justice while transitioning into high school in the 2020-2021 school year and attending school virtually and in-person during the continued pandemics of Covid-19 and racial injustice. Díaz provides insights on how educational leaders and staff can build relationships and reach out to students and families in order to support student well-being and safety. Díaz's experiences and observations highlight the myriad issues students and families face and the importance of supporting students through increasing awareness of resources and developing coping …
A Phase 2 Trial Of Ibrutinib And Nivolumab In Patients With Relapsed Or Refractory Classical Hodgkin's Lymphoma., Walter Hanel, Polina Shindiapina, David A Bond, Yazeed Sawalha, Narendranath Epperla, Timothy Voorhees, Rina Li Welkie, Ying Huang, Gregory K Behbehani, Xiaoli Zhang, Eric Mclaughlin, Wing K Chan, Jonathan E Brammer, Samantha Jaglowski, John C Reneau, Beth A Christian, Basem M William, Jonathon B Cohen, Robert A Baiocchi, Kami Maddocks, Kristie A Blum, Lapo Alinari
A Phase 2 Trial Of Ibrutinib And Nivolumab In Patients With Relapsed Or Refractory Classical Hodgkin's Lymphoma., Walter Hanel, Polina Shindiapina, David A Bond, Yazeed Sawalha, Narendranath Epperla, Timothy Voorhees, Rina Li Welkie, Ying Huang, Gregory K Behbehani, Xiaoli Zhang, Eric Mclaughlin, Wing K Chan, Jonathan E Brammer, Samantha Jaglowski, John C Reneau, Beth A Christian, Basem M William, Jonathon B Cohen, Robert A Baiocchi, Kami Maddocks, Kristie A Blum, Lapo Alinari
Oncology Articles
BACKGROUND: Relapsed or refractory classical Hodgkin lymphoma (cHL) remains a difficult treatment challenge. Although checkpoint inhibitors (CPI) have provided clinical benefit for these patients, responses are generally not durable, and progression eventually occurs. Discovering combination therapies which maximize the immune response of CPI therapy may overcome this limitation. We hypothesized that adding ibrutinib to nivolumab will lead to deeper and more durable responses in cHL by promoting a more favorable immune microenvironment leading to enhanced T-cell-mediated anti-lymphoma responses.
METHODS: We conducted a single arm, phase II clinical trial testing the efficacy of nivolumab in combination with ibrutinib in patients ≥18 …
Maine Update: Mills Remains Popular Governor; Majorities Favor Voter Id & Family Leave Bills 2/24/2023, Unh Survey Center
Maine Update: Mills Remains Popular Governor; Majorities Favor Voter Id & Family Leave Bills 2/24/2023, Unh Survey Center
All UNH Survey Center Polls
A majority of Mainers continue to approve of Janet Mills’ performance as Maine's Governor and she remains personally popular in the state. Majorities of Mainers support voter identification and family leave bills, as well as a bill which would allow abortion after 24 weeks if approved by a doctor. Most Mainers consider homelessness to be a serious problem in the state and the cost of living and housing are most often mentioned as the most important problems facing Maine.
Does Structural Racism Influence How Black/African Americans Define Memory Loss And Cognitive Impairment? An Africana Phenomenological Study, Andre Pruitt
Dissertations and Theses
With the variety of research about dementia and Alzheimer's disease (AD), few studies have explored the effect of social structures, such as racism, on how Black/African Americans conceptualize memory loss, dementia, or AD. Furthermore, limited within the scholarship are the environmental factors and structural racism that are thought to influence cognitive impairments and meaning making about cognitive decline impacting Black/African Americans.
Most U.S. research centers on methodologies and epistemologies grounded in Eurocentric ways of knowing (objectivity, individuality, either/or logic). However, Eurocentric methodologies fail to acknowledge the cultural experiences with memory loss, cognitive impairment, dementia, and AD, as well as the …
Midwest Philosophy Colloquium To Focus On Social Epistemology, Communications And Marketing
Midwest Philosophy Colloquium To Focus On Social Epistemology, Communications And Marketing
Campus News Archive
No abstract provided.
Mitochondrial Phosphatidylethanolamine Modulates Ucp1 To Promote Brown Adipose Thermogenesis, Jordan M Johnson, Irfan J Lodhi, Et Al.
Mitochondrial Phosphatidylethanolamine Modulates Ucp1 To Promote Brown Adipose Thermogenesis, Jordan M Johnson, Irfan J Lodhi, Et Al.
2020-Current year OA Pubs
Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner mitochondrial membrane (IMM), where it dissipates membrane potential independent of adenosine triphosphate (ATP) synthase. Here, we provide evidence that phosphatidylethanolamine (PE) modulates UCP1-dependent proton conductance across the IMM to modulate thermogenesis. Mitochondrial lipidomic analyses revealed PE as a signature molecule whose abundance bidirectionally responds to changes in thermogenic burden. Reduction in mitochondrial PE by deletion of phosphatidylserine decarboxylase (PSD) made mice cold intolerant and insensitive to β3 adrenergic receptor agonist-induced increase in whole-body oxygen …
Ergot And Sterility In Bahiagrass: Genotypic And Environmental Effects On Seed Yield Potential, Javier Do Canto, Rafael Reyno, Hector Oberti, Marco Dalla Rizza, Daniel Real
Ergot And Sterility In Bahiagrass: Genotypic And Environmental Effects On Seed Yield Potential, Javier Do Canto, Rafael Reyno, Hector Oberti, Marco Dalla Rizza, Daniel Real
Grain and Other Field Crops Research Articles
Ergot disease (Claviceps paspali) and sterility have the potential to reduce seed yield in bahiagrass (Paspalum notatum Flüggé). Our objective was to determine the genotypic and environmental effects on seed yield, and the levels of ergot and sterility. Seventeen genotypes were evaluated in three locations across two years for seed yield, ergot severity, and total seed fractions (percentage of full seeds, ergot sclerotia and empty seeds). The percentage of full seeds and total seed yield were correlated (r = 0.52) but both were negatively correlated with the percentage of ergot sclerotia (r = −0.81 and −0.51). …
Generative Artificial Intelligence And Copyright Law, Christopher T. Zirpoli
Generative Artificial Intelligence And Copyright Law, Christopher T. Zirpoli
Copyright, Fair Use, Scholarly Communication, etc.
Recent innovations in artificial intelligence (AI) are raising new questions about how copyright law principles such as authorship, infringement, and fair use will apply to content created or used by AI. So-called “generative AI” computer programs—such as Open AI’s DALL-E 2 and ChatGPT programs, Stability AI’s Stable Diffusion program, and Midjourney’s self-titled program—are able to generate new images, texts, and other content (or “outputs”) in response to a user’s textual prompts (or “inputs”). These generative AI programs are “trained” to generate such works partly by exposing them to large quantities of existing works such as writings, photos, paintings, and other …
2023-02-24, Board Of Regents, Murray State University
2023-02-24, Board Of Regents, Murray State University
Board of Regents Meeting Minutes
No abstract provided.
Data From: Mechanisms Of Gill-Clogging By Hagfish Slime, Luke Taylor, Gaurav Chaudhary, Gaurav Jain, Andrew Lowe, Andre Hupe, Atsuko Negishi, Yu Zeng, Randy Ewoldt, Douglas Fudge
Data From: Mechanisms Of Gill-Clogging By Hagfish Slime, Luke Taylor, Gaurav Chaudhary, Gaurav Jain, Andrew Lowe, Andre Hupe, Atsuko Negishi, Yu Zeng, Randy Ewoldt, Douglas Fudge
Biology, Chemistry, and Environmental Sciences Faculty Data Sets
Abstract of Proc. Roy. Soc. article:
Hagfishes defend themselves from gill-breathing predators by producing large volumes of fibrous slime when attacked. The slime’s effectiveness comes from its ability to clog predators’ gills, but the mechanisms by which hagfish slime clogs are uncertain, especially given its remarkably dilute concentration of solids. We quantified the clogging performance of hagfish slime over a range of concentrations, measured the contributions of its mucous and thread components, and measured the effect of turbulent mixing on clogging. To assess the porous structure of hagfish slime, we used a custom device to measure its Darcy permeability. We …
Determinan Perilaku Pemeriksaan Payudara Sendiri (Sadari) Pada Mahasiswi Fakultas Kesehatan Masyarakat Universitas Indonesia Tahun 2022, Anna Triana, Ira Aulia, Yolanda Handayani
Determinan Perilaku Pemeriksaan Payudara Sendiri (Sadari) Pada Mahasiswi Fakultas Kesehatan Masyarakat Universitas Indonesia Tahun 2022, Anna Triana, Ira Aulia, Yolanda Handayani
Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan
Kanker payudara merupakan kanker dengan angka kejadian paling tinggi di dunia maupun di Indonesia. Keterlambatan diagnosa merupakan salah satu masalah dalam penanganan kanker payudara. Padahal keterlambatan diagnosa dapat dicegah dengan rutin melakukan pemeriksaan deteksi dini kanker payudara, salah satunya yaitu pemeriksaan payudara sendiri (SADARI). Penelitian ini merupakan penelitian analitik dengan metode kuantitatif dan menggunakan desain cross-sectional. Populasi dalam penelitian ini adalah seluruh mahasiswi kelas ekstensi angkatan tahun 2020, 2021, dan 2022 di Fakultas Kesehatan Masyarakat Universitas Indonesia. Pengambilan sampel dilakukan menggunakan teknik stratified sampling dengan hasil perhitungan akhir sampel sebanyak 108 responden. Pengambilan data dilakukan dengan instrumen kuesioner yang …
Autokorelasi Spasial Prevalensi Stunting Di Jawa Barat Tahun 2021, Aldila Riznawati, Deny Yudhistira, Martya Rahmaniati, Tiopan Sipahutar, Tris Eryando
Autokorelasi Spasial Prevalensi Stunting Di Jawa Barat Tahun 2021, Aldila Riznawati, Deny Yudhistira, Martya Rahmaniati, Tiopan Sipahutar, Tris Eryando
Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan
Angka prevalensi stunting Provinsi Jawa Barat tahun 2021 sebesar 24,5% dan menjadi salah satu provinsi dengan kategori stunting kronis-akut di Indonesia. Analisis spasial digunakan untuk mengetahui apakah terdapat korelasi secara spasial antar wilayah kabupaten/kota di Jawa Barat berdasarkan prevalensi stunting. Hasil penelitian menunjukkan adanya autokorelasi spasial positif dan terdapat korelasi secara spasial yang artinya prevalensi stunting di satu wilayah kabupaten/kota berkaitan dengan wilayah disekitarnya. Wilayah yang menjadi hotspot stunting di Jawa Barat tahun 2021 berdasarkan pola kluster yang terbentuk adalah Kabupaten Bandung, Kabupaten Bandung Barat, dan Kota Bandung. Ketiga wilayah ini menjadi prioritas utama dalam melakukan intervensi penurunan prevalensi stunting …
Keterpaparan Informasi Narkoba Dan Perilaku Pencarian Rehabilitasi: Studi Kasus Pada Penyalahguna Narkoba Di Rumah Kos, Yulia Pratiwi, Besral Besral
Keterpaparan Informasi Narkoba Dan Perilaku Pencarian Rehabilitasi: Studi Kasus Pada Penyalahguna Narkoba Di Rumah Kos, Yulia Pratiwi, Besral Besral
Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan
Keterpaparan informasi narkoba merupakan faktor penting dalam pengetahuan dan perubahan perilaku, terutama untuk melakukan rehabilitasi. Rumah kos merupakan populasi yang dianggap rawan terhadap penyalahgunaan narkoba. Tujuan dari penelitian ini adalah untuk mengetahui hubungan keterpaparan informasi narkoba dengan perilaku pencarian rehabilitasi pada pengguna narkoba di rumah kos. Analisis regresi logistik ganda digunakan untuk menilai hubungan yang signifikan pada α=0,05. Hasil penelitian ini menunjukkan bahwa penyalahguna narkoba di rumah kos yang memiliki keterpaparan informasi yang baik memiliki kecenderungan untuk 3,8 kali lebih besar untuk berperilaku mencari rehabilitasi dibandingkan dengan mereka yang keterpaparan informasinya kurang (ORa=3,8; 95% CI=0,7 – 21,5), setelah dikontrol oleh …
Hubungan Status Ekonomi Dengan Jumlah Anak Lahir Hidup Pada Wanita Kelompok Usia Kurang Dari 45 Tahun Dan Kelompok Usia 45-49 Tahun Kawin (Analisis Data Sdki 2017), Meilina Suwandi, Indang Trihandini
Hubungan Status Ekonomi Dengan Jumlah Anak Lahir Hidup Pada Wanita Kelompok Usia Kurang Dari 45 Tahun Dan Kelompok Usia 45-49 Tahun Kawin (Analisis Data Sdki 2017), Meilina Suwandi, Indang Trihandini
Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan
Permasalahan kependudukan masih sangat kompleks. Salah satu hal nyata yang dihadapi adalah pertumbuhan penduduk yang relatif masih tinggi. Salah satu bagian dari pertumbuhan penduduk tidak terlepas dari jumlah anak lahir hidup. Salah satu faktor yang diduga berhubungan dengan jumlah anak lahir hidup adalah status ekonomi. Penelitian ini dilakukan untuk melihat besar hubungan antara status ekonomi dengan jumlah anak lahir hidup pada wanita usia kurang dari 45 tahun berstatus kawin yang masa reproduksinya masih berjalan dan usia 45-49 tahun berstatus kawin yang sudah masuk ke akhir masa reproduksi. Penelitian ini dilakukan menggunakan desain studi potong lintang menggunakan data Survei Demografi Kesehatan …
2023 New Music Festival: Concert I Featuring Ensemble Dal Niente, February 24, 2023 [Program], University Of Northern Iowa. School Of Music.
2023 New Music Festival: Concert I Featuring Ensemble Dal Niente, February 24, 2023 [Program], University Of Northern Iowa. School Of Music.
Music Recital Programs
Program of a music recital given by faculty, students, or guest artists from the School of Music at the University of Northern Iowa.
2022-2023 Performance Forum - February 24, 2023, Juan Diaz Quijano, Silvia Valdivia Villasante, Jasmin Abdunazarova, Adriana Fernandez, Amelia Dixon, Daniel Guevara, Emin Huseynov, Sol Ochoa Castro, Megan Hagel, Vincent Cart-Sanders, Dina Bikzhanova, Francesca Puro, Jon Cruz
2022-2023 Performance Forum - February 24, 2023, Juan Diaz Quijano, Silvia Valdivia Villasante, Jasmin Abdunazarova, Adriana Fernandez, Amelia Dixon, Daniel Guevara, Emin Huseynov, Sol Ochoa Castro, Megan Hagel, Vincent Cart-Sanders, Dina Bikzhanova, Francesca Puro, Jon Cruz
Performance Forum
No abstract provided.
Festschrift Symposium: Honoring Professor Sam Pillsbury, Michael Waterstone, Guyora Binder, Mary Graw Leary, Deborah W. Denno, Stephen J. Morse, Scott Wood, John T. Nockleby, Gary C. Williams, Samantha Buckingham, Samuel Pillsbury, Kevin Lapp
Festschrift Symposium: Honoring Professor Sam Pillsbury, Michael Waterstone, Guyora Binder, Mary Graw Leary, Deborah W. Denno, Stephen J. Morse, Scott Wood, John T. Nockleby, Gary C. Williams, Samantha Buckingham, Samuel Pillsbury, Kevin Lapp
Journal Articles
The Loyola of Los Angeles Law Review is pleased to publish this Festschrift Symposium Honoring Professor Samuel Pillsbury. The following is an edited transcript of the live symposium held at LMU Loyola Law School on Friday, March 25, 2022.
Hybrid Modeling For Electrochemical Systems, Luis Alejandro Briceno-Mena
Hybrid Modeling For Electrochemical Systems, Luis Alejandro Briceno-Mena
LSU Doctoral Dissertations
The discovery of new materials like catalysts, polymeric films, and biomolecules, is driven by industrial needs such as improving reaction or separation selectivity, enhancing therapeutic effects on medical treatments, or reducing costs of replacement. However, deployment of these advances in industrial applications is often hindered by the lack of models needed for design and optimization. Due to the novelty of materials and devices, experimental data and first principles' knowledge are scarce, making it hard to build models either via data-driven or knowledge based approaches. In this context, a way to efficiently combine domain knowledge with data could provide a pathway …
Rank Ags Identification Scheme And Signature Scheme, Vaishnavi Nagaraja, Muhammad Rezal Kamel Ariffin, Terry Shue Chien Lau, Nurul Nur Hanisah Adenan, Ji Jian Chin, Sook Chin Yip, Timothy Tzen Vun Yap
Rank Ags Identification Scheme And Signature Scheme, Vaishnavi Nagaraja, Muhammad Rezal Kamel Ariffin, Terry Shue Chien Lau, Nurul Nur Hanisah Adenan, Ji Jian Chin, Sook Chin Yip, Timothy Tzen Vun Yap
School of Engineering, Computing and Mathematics
The identification protocol is a type of zero-knowledge proof. One party (the prover) needs to prove his identity to another party (the verifier) without revealing the secret key to the verifier. One can apply the Fiat–Shamir transformation to convert an identification scheme into a signature scheme which can be used for achieving security purposes and cryptographic purposes, especially for authentication. In this paper, we recall an identification protocol, namely the RankID scheme, and show that the scheme is incorrect and insecure. Then, we proposed a more natural approach to construct the rank version of the AGS identification protocol and show …
Microrna Profiles In Intestinal Epithelial Cells In A Mouse Model Of Sepsis, Eiji Kawamoto, Juneyoung Lee, Eun Jeong Park
Microrna Profiles In Intestinal Epithelial Cells In A Mouse Model Of Sepsis, Eiji Kawamoto, Juneyoung Lee, Eun Jeong Park
Faculty, Staff and Student Publications
Sepsis is a systemic inflammatory disorder that leads to the dysfunction of multiple organs. In the intestine, the deregulation of the epithelial barrier contributes to the development of sepsis by triggering continuous exposure to harmful factors. However, sepsis-induced epigenetic changes in gene-regulation networks within intestinal epithelial cells (IECs) remain unexplored. In this study, we analyzed the expression profile of microRNAs (miRNAs) in IECs isolated from a mouse model of sepsis generated via cecal slurry injection. Among 239 miRNAs, 14 miRNAs were upregulated, and 9 miRNAs were downregulated in the IECs by sepsis. Upregulated miRNAs in IECs from septic mice, particularly …