Digital Commons Network^™

Alternative Anticoagulation Strategies For Heparin-Intolerant Patients Undergoing Cardiopulmonary Bypass: A Scoping Review Of Patient Outcomes, Zachary Nelson

Student Works

Background/Introduction: Heparin intolerance, most notably heparin-induced thrombocytopenia (HIT), presents a major clinical challenge during cardiopulmonary bypass (CPB), where systemic anticoagulation is essential for safe circulation through the extracorporeal circuit. While several alternative anticoagulants have been described, there is limited consensus regarding their safety, dosing, and outcomes. The objective of this study was to map existing evidence describing alternative anticoagulation strategies for heparin-intolerant adult patients undergoing CPB and to summarize reported patient outcomes, dosing strategies, and intraoperative management considerations.

Methodology: This scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) …

Peaks Island Star : April 2026, Vol. 46, Issue 4, Service Agencies Of The Island

Peaks Island Star, 2026

The Peaks Island Star is the newsletter of the island's service agencies and other community news.

Oral History Of Dr. Edward Yost, Conducted On February 14, 2026 By Mallory Lough, Edward Yost, Mallory Lough

HIST 4798/5798: Recording Memory: Methods and Uses of Oral History

This interview, conducted by Mallory Lough in February 2026, documents the life and career of Dr. Edward Yost, a retired professor from Ohio University’s College of Business. Dr. Yost grew up in rural Litchfield, Ohio, where he was part of a fourth-generation dairy farming family. After his family’s farm declined, he pursued higher education using the GI Bill, eventually earning a PhD in Business Administration. Mentorship played a key role in guiding him into academia. At Ohio University, where he spent over 30 years, Yost held numerous leadership roles, particularly in graduate and international business programs. He helped develop and …

Oral History Of Ronald Lykins Conducted By Mallory Lough On March 12, 2026, Ronald Lykins, Mallory Lough

HIST 4798/5798: Recording Memory: Methods and Uses of Oral History

Ronald Lykins is a former professor within the College of Business at Ohio University. Raised in rural Adams County, Ohio, in a family facing significant economic hardships, Lykins grew up in a household with no running water or electricity. These early experiences shaped his work ethic, along with giving him a deep appreciation for helping others and granting opportunities. Ron enrolled at Ohio University as a first generation student, graduating with his MBA in 1967 and his PhD in 1971. Following his graduation, Ron developed a career in accounting and financial services, eventually founding his own accounting firm in 1969. …

Panitikan At Pakikibakang Pesante: Kasaysayan Ng Pakikibaka Para Sa Repormang Agraryo Sa Tatlong Nobela Ni Lazaro Francisco (Literature And Peasant Struggle: History Of Agrarian Reform Struggles In Three Novels Of Lazaro Francisco), Jester Gabriel De Leon

Akda: The Asian Journal of Literature, Culture, Performance

Binasa ng papel na ito ang tatlong nobela ng Pambansang Alagad ng Sining sa Panitikan na si Lazaro Francisco na Ama (1929), Maganda Pa ang Daigdig (1955), at Daluyong (1962), upang ipatampok ang kasaysayan ng pakikibaka repormang agraryo buhat sa iba pang mga tunggalian na binunga ng nagbabanggaang interes ng mga magbubukid at panginoong maylupa sa isang lipunang malapyudal sang-ayon sa pagsusuring Maoismo. Matapat na isiniwalat ng mga akda ni Francisco ang kalagayan ng magbubukid sa rurok ng malapyudal na pananamantala mula sa panahon ng pananakop ng Estado Unidos hanggang sa panunungkulan ng mga burukrata-kapitalista matapos ang Ikalawang Digmaang Pandaigdig. …

Literary Colonization And Locating Avenues Of Subversion In Bobby Flores-Villasis' Suite Bergamasque, Michael Aaron C. Gomez

Akda: The Asian Journal of Literature, Culture, Performance

This paper examines four short stories included in the collection titled Suite Bergamasque, written by multi-awarded Negrense playwright and fictionist Bobby Flores-Villasis. A materialist reading situates Villasis within the canon of Philippine literature in English and analyzes the way his stories formally render the class antagonisms of history through the interconnected narratives of Dumaguete City’s sugar elite. Finally, this paper also contends that the political imagination of Villasis’ work exhorts contemporary Dumaguete writers to critically examine inherited hagiographies in order to describe fully the conditions that have shaped the city into its contemporary formation, particularly the phenomena of gentrification …

Gregor Samsa’S Pagkagimata (Awakening) In Bikol: A Becoming-Minor In Translation, Victor John M. Loquias

Akda: The Asian Journal of Literature, Culture, Performance

Kristian Cordero’s translation of Franz Kafka’s Metamorphosis instantiates what the philosophers Gilles Deleuze and Felix Guattari call minor literature. Preferring the Bikol term Pagkagimata—the literal event of Gregor Sama’s becoming-animal in the novel as title of the translation and the utilization of the Rinconada Bikol language for the transformed Samsa—Cordero has typified a perspective of translation that challenges the popular view of fluent translation from the source text to the target language. Exemplifying the concept of becoming-minor of Deleuze and Guattari and deploying Lawrence Venuti’s notion of the “remainder,” An Pagkagimata ni Gregor Samsa exhibits a deterritorialization of Bikol …

Preliminaries & Editor's Introduction: In The Work Of Tension, Dinah Tapia Roma

Akda: The Asian Journal of Literature, Culture, Performance

No abstract provided.

Raheemah Whitmore V. Raheem Whitmore

2026 Decisions

USDC for the Eastern District of Pennsylvania

Reuven Lyak V. City Of Hackensack

2026 Decisions

USDC for the District of New Jersey

Kason Jamison V. Chrislyn Morgan

2026 Decisions

USDC for the District of New Jersey

Antoine Poteat V. Gerald Lydon

2026 Decisions

USDC for the Eastern District of Pennsylvania

Novel Adult Learning-Based Curriculum For Pathology Residents, Hafsa Nebbache, Aaron Daniel Shmookler, Justin Rueckert, Daniel Crump, Sahar Nozad, Nathan Shelman, Derek B. Allison, Robert J. Mcdonald, C. Darrell Jennings, Leanna Brignola, Therese J. Bocklage, Janna H. Neltner

Markey Cancer Center Faculty Publications

Active learning forms the foundation of adult education methodology as it promotes durable retention of knowledge in accessible long-term memory. The most successful active learning strategy uses periodic testing, a memory recall, application, and consolidation activity termed “retrieval practice.” After reviewing adult learning science evidence, we created a two-year anatomic and clinical pathology residency core curriculum (Pathology Core Curriculum) in which we deployed six principles of adult learning, prioritizing retrieval practice as our key learning strategy. We hypothesized that the Pathology Core Curriculum would improve long-term knowledge retention which would correlate with progressively higher retrieval practice and resident in-service exam …

Information-Content-Informed Kendall-Tau Correlation Methodology, Robert M. Flight, Praneeth S. Bhatt, Hunter N.B. Moseley

Markey Cancer Center Faculty Publications

Background: Almost all correlation measures currently available are unable to directly handle missing values. Typically, missing values are either ignored completely by removing them or are imputed and used in the calculation of the correlation coefficient. In either case, the correlation value will be impacted based on the perspective that the missing data represents no useful information. However, missing values occur in real datasets for a variety of reasons. In metabolomics datasets a major reason for missing values is that a specific measurable phenomenon falls below the detection limits of the analytical instrumentation (left-censored values). These missing data are not …

Mapping The Polar Neuro-Interactome Of Garcinia Mangostana Against The Ad-Pd-Als Nexus, Rahni Hossain, Sirirat Surinkaew, Pradoldej Sompol, Nasmah K. Bastaki, Rifat Jafrin, Nazim Sekeroglu, Jitbanjong Tangpong

Markey Cancer Center Faculty Publications

Background/Objectives: Neurodegenerative diseases like Alzheimer’s, Parkinson’s, and Amyotrophic lateral sclerosis (ALS) share common molecular pathways, including neuroinflammation and oxidative stress, which complicate the effectiveness of single-target treatments. Garcinia mangostana L. (mangosteen) has shown neuroprotective properties, but previous studies focused on lipophilic xanthones, which have poor bioavailability and uncertain blood–brain barrier permeability. Methods: In the current study, polar metabolites from G. mangostana peel aqueous extract (GMPE) were assessed for potential multi-target interactions via UHPLC-QTOF-MS-based metabolomics, systems pharmacology, and molecular docking analysis. Further, in silico ADMET screening and network-based analyses assessed for overlap between GMPE compounds and genes associated with neurodegeneration (AD, …

Role Of Succinate Dehydrogenase In Age-Related Th17 Inflammation, Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica-Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath

Markey Cancer Center Faculty Publications

Age-related cellular changes negatively impact CD4⁺ T cell function. Our prior work showed that mitochondrial complex II (succinate dehydrogenase [SDH]) expression was upregulated in T cells from older (O) adults (60–80 years old). T cells from older adults also produced higher amounts of cytokines generally considered proinflammatory, such as Th17 cytokines IL-17A/F and IL-21, and the Th-17-supportive cytokine IL-6, compared to T cells from younger (Y) adults (25–40 years old). The objective of our study is to evaluate whether hyperactivation of SDH is required for the induction of proinflammatory cytokines and the mechanistic link between SDH and Th17 cytokine …

Systemic Consequences Of Chronic Ethanol Intake, Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann

Markey Cancer Center Faculty Publications

Chronic ethanol (EtOH) consumption is a major contributor to multi-organ dysfunction, yet its systemic effects remain incompletely understood. To address this, we utilized a physiologically relevant long-term mouse model, administering 20% EtOH in drinking water for 60 weeks, to investigate the integrated consequences of chronic exposure. EtOH-consuming mice (0.4–0.5 mL/day) exhibited > 30% reductions in chow and fluid intake, resulting in a 12% decrease in total caloric intake compared to controls (p < 0.001). Body mass remained similar until Week 52, after which EtOH-treated mice had lower body mass due to reductions in both lean and fat mass (p ≤ 0.004). Functional assessments revealed impaired treadmill endurance (−17%) and grip strength (−11%) (p ≤ 0.037), while motor coordination remained unaffected (p = 0.203). Chronic EtOH exposure significantly altered gut microbiota composition, reducing Lactobacillus and enriching Faecalibaculum, Clostridium, and Bifidobacterium at the genus level. These changes were accompanied by marked depletion of short-chain fatty acids (p ≤ 0.05). Indirect markers of gut permeability (serum LPS & zonulin) and liver injury (serum ALT & AST, hepatic amyloid content) were elevated, alongside increased total cholesterol and > 62% upregulation of hepatic TNFα, IL-6 & serum amyloid A (p ≤ 0.046). EtOH also induced dyslipidemia and glucose intolerance (p ≤ 0.041), although transcriptomic changes in white adipose …

Machine Learning And Multisensor Data Fusion For Forest Above Ground Biomass Estimation In Arkansas, Abdullah Al Saim, Mohamed Aly

Geosciences Faculty Publications and Presentations

Forests are essential for biodiversity conservation, climate change, natural education, scientific research, and carbon sequestration. This study uses machine learning-based Random Forest (RF) regression to estimate the Above Ground Biomass (AGB) of the Ozark and Ouachita forests at a 10-meter resolution by combining data from Sentinel-2, Sentinel-1, and GEDI (Global Ecosystem Dynamics Investigation) on Google Earth Engine. The RF model included 34 out of 154 variables representing topographical, spectral, and textural factors demonstrating strong correlations with measured biomass. The RF model showed strong performance with R-squared and RMSE values of 0.95 and 18.46 for the training dataset and 0.75 and …

Freedom Readers And Sustainable Development Goal 4: Advancing Literacy In Low-Income Communities Of South Carolina, Madison Hayes

Goal 4: Quality Education

No abstract provided.

Pay-Per-Crawl Pricing For Ai: The Lm-Tree Agent, Richard Archer, Soheil Ghili, Nima Haghpanah

Cowles Foundation Discussion Papers

No abstract provided.

Growth With New And Old Technologies, Bernardo Ribeiro

Cowles Foundation Discussion Papers

This paper proposes a semi-endogenous growth theory that incorporates technology vintages and the endogenous evolution of multiple technological paradigms through innovation. It provides a characterization of both balanced growth equilibrium and transitional dynamics in an environment where new technologies continuously emerge. From a positive perspective, the model rationalizes two distinct empirical patterns. Using two centuries of US patent data, I first document that the age profile of patents has a pronounced hump shape: most contemporary patents build upon technologies that are between 50 and 100 years old. Second, this age profile has remained stable throughout the past century. From a …

Soft-Floor Auctions: Harnessing Regret To Improve Efficiency And Revenue, Dirk Bergemann, Kevin Breuer, Peter Crampton, Jack Hirsch, Yero S. Ndiaye, Axel Ockenfels

Cowles Foundation Discussion Papers

A soft-floor auction asks bidders to accept an opening price to participate in a second-price auction. If no bidder accepts, lower bids are considered using first-price rules. Soft floors are common despite being irrelevant with standard assumptions. When bidders regret losing, soft-floor auctions are more efficient and profitable than standard optimal auctions. Revenue increases as bidders are inclined to accept the opening price to compete in a regret-free second-price auction. Efficiency improves because a soft floor allows for a lower hard reserve, reducing the frequency of no sale. Theory and experiment confirm these motivations from practice.

Early Childcare Attendance And Cognitive Skills In Adolescence, Ingvild Almas, Nina Drange, Costas Meghir, Henrik Daae Zachrisson

Cowles Foundation Discussion Papers

This paper examines the impact of early childcare on academic achievement for children in grade 5 and grade 9, based on a 2003 policy expansion that created quasi-random variation in slot availability for children aged 1–2. Starting childcare one year earlier increases math scores by 9.7% of a standard deviation (SD) in grade 9. Children whose mothers do not hold a high school diploma benefit by a significant 0.28% of a SD at grade 9, reducing the math achievement gap from children of higher-educated mothers by about one third. We also present evidence of strong improvements for children of immigrants.

Capital Flows And The Global Collateral Cycle, Ana Fostel, John Geanakoplos, Gregory Phelan

Cowles Foundation Discussion Papers

Cross-country disparities in collateral technologies alone can account for large capital flows among mature economies, and allow the most advanced country to run a permanent trade deficit. When the collateral technology advantage is in creating negative beta (super safe) financial assets backed by positive beta assets, a Global Collateral Cycle emerges, with pro-cyclical gross and net flows and increased global asset price volatility. The supply of super safe assets is necessarily curtailed in downturns, providing a complementary (supply) channel to the flight to safety (demand) channel for explaining why US safe asset prices rise during crises.

Organizational Targets In General Equilibrium, Joel P. Flynn, George Nikolakoudis, Karthik Sastry

Cowles Foundation Discussion Papers

We build a general equilibrium model in which firms endogenously choose whether to target prices or quantities. We characterize how these choices of organizational targets depend on firms' uncertainty about microeconomic and macroeconomic factors. In equilibrium, the transmission of both nominal and real shocks hinges on firms' organizational targets. For example, under otherwise identical microfoundations, money is neutral under quantity targets and non-neutral under price targets. We further characterize how targets shape firms' strategic interactions and prove that the macroeconomic uncertainty that arises from each choice of targets reinforces incentives to choose that target. That is, choices of organizational targets …

Training Language Models For Bilateral Trade With Private Information, Dirk Bergemann, Soheil Ghili, Xinyang Hu, Chuanhao Li, Zhuoran Yang

Cowles Foundation Discussion Papers

Bilateral bargaining under incomplete information provides a controlled testbed for evaluating large language model (LLM) agent capabilities. Bilateral trade demands individual rationality, strategic surplus maximization, and cooperation to realize gains from trade. We develop a structured bargaining environment in which LLMs negotiate via tool calls within an event-driven simulator, separating binding offers from natural-language messages to enable automated evaluation. The environment serves two purposes: as a benchmark for frontier models and as a training environment for open-weight models via reinforcement learning. In benchmark experiments, a round-robin tournament among five frontier models (15,000 negotiations) reveals that effective strategies implement price discrimination …

Complex Iliac Artery And Iliocaval Venous Reconstruction Using Temporary, Redundant Graft To Facilitate Resection Of Recurrent Metastatic Sex Stromal Tumor, Shah-Jahan M Dodwad, Blaz Podgorsek, Ezra Koh, Taha S Zaidi, Justin E Bird, Shalin S Patel, Thanila A Macedo, Gustavo S Oderich

Faculty, Staff and Student Publications

We report a complex case of recurrent, metastatic sex cord stromal tumor involving the pelvic vasculature and spinal nerves. Posterior and anterior approaches were required with redo iliac artery reconstruction using a temporary, redundant aortoiliac to right external iliac artery graft and iliocaval venous reconstruction. After completion of tumor resection from nerve structures, reconstruction of the right iliac veins was completed and the redundant aortoiliac arterial graft was shortened. The redundant graft minimized ischemia time, enabling meticulous dissection and tumor removal. This case underscores the importance of multidisciplinary collaboration in managing rare, aggressive malignancies with complex vascular and neural involvement.

Complex Iliac Artery And Iliocaval Venous Reconstruction Using Temporary, Redundant Graft To Facilitate Resection Of Recurrent Metastatic Sex Stromal Tumor, Shah-Jahan M Dodwad, Blaz Podgorsek, Ezra Koh, Taha S Zaidi, Justin E Bird, Shalin S Patel, Thanila A Macedo, Gustavo S Oderich

Faculty, Staff and Student Publications

We report a complex case of recurrent, metastatic sex cord stromal tumor involving the pelvic vasculature and spinal nerves. Posterior and anterior approaches were required with redo iliac artery reconstruction using a temporary, redundant aortoiliac to right external iliac artery graft and iliocaval venous reconstruction. After completion of tumor resection from nerve structures, reconstruction of the right iliac veins was completed and the redundant aortoiliac arterial graft was shortened. The redundant graft minimized ischemia time, enabling meticulous dissection and tumor removal. This case underscores the importance of multidisciplinary collaboration in managing rare, aggressive malignancies with complex vascular and neural involvement.

Decarceration & Voting Rights Advocacy, Sophie E. Trudgeon

Graduate Student Portfolios, Professional Papers, and Capstone Projects

Portfolio detailing my MSW practicum placement at Catalyst MT under the Justice Initiative and the growth that accompanied it.

Msw Portfolio: Grounded In Perpetuity And Well-Being Of The Future Generation, Silver A. Little Eagle

Graduate Student Portfolios, Professional Papers, and Capstone Projects

The MSW Portfolio, Grounded in Perpetuity and Well-being of the Future Generation, by Silver Little Eagle (Northern Cheyenne), is an Advanced Integral Practice portfolio submitted in partial fulfillment of the Master of Social Work degree at the University of Montana. Integrating the core competencies outlined by the University of Montana School of Social Work and the Council on Social Work Education, this portfolio draws on the author's identity as an Indigenous social work practitioner, as a citizen of the Northern Cheyenne Tribe, as a Tsé-tsėhéstaestse naa Só'taeo'o woman, as an eldest sister raised by her grandmothers, and as a Youth …