Digital Commons Network^™

Itch And Janus Kinase Inhibitors, Yujin Han, Yu Ri Woo, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim

Faculty, Staff and Student Publications

Itch is a common skin symptom, with complex aetiology and pathogenesis. It is mediated by 2 pathways, the histaminergic and non-histaminergic pathways. Chronic itch is understood to be processed by the latter and is difficult to treat with traditional pruritus therapies. The Janus kinase and signal transducer and activator of transcription pathway is a signalling mechanism that regulates gene expression through various cytokines. Janus kinase inhibitors, which have been tested and used for several autoimmune diseases, have also been shown to be effective for itch through clinical trials and case reports. Janus kinase inhibitors could be a good choice for …

Baseline Extracellular Vesicle Tgf-Β Is A Predictive Biomarker For Response To Immune Checkpoint Inhibitors And Survival In Non-Small Cell Lung Cancer, Diego De Miguel-Perez, Alessandro Russo, Muthukumar Gunasekaran, Francesco Buemi, Lisa Hester, Xiaoxuan Fan, Brandon A Carter-Cooper, Rena G Lapidus, Ariel Peleg, Marisol Arroyo-Hernández, Andres F Cardona, Aung Naing, Fred R Hirsch, Philip C Mack, Sunjay Kaushal, Maria Jose Serrano, Vincenzo Adamo, Oscar Arrieta, Christian Rolfo

Faculty, Staff and Student Publications

Background: Immune-checkpoint inhibitors (ICIs) are an effective therapeutic strategy, improving the survival of patients with lung cancer compared with conventional treatments. However, novel predictive biomarkers are needed to stratify which patients derive clinical benefit because the currently used and highly heterogenic histological PD-L1 has shown low accuracy. Liquid biopsy is the analysis of biomarkers in body fluids and represents a minimally invasive tool that can be used to monitor tumor evolution and treatment effects, potentially reducing biases associated with tumor heterogeneity associated with tissue biopsies. In this context, cytokines, such as transforming growth factor-β (TGF-β), can be found free in …

Incentive Mechanisms To Exploit Intraseasonal Price Arbitrage Opportunities For Smallholder Farmers: Experimental Evidence From Malawi, Tabitha Nindi, Jacob Ricker-Gilbert, Jonathan Bauchet

Department of Agricultural Economics Faculty Publications

Seasonal commodity price fluctuations can potentially offer farmers arbitrage opportunities to increase their income. However, smallholder farmers in most of sub-Saharan Africa often do not exploit these opportunities to the fullest extent possible. To inform this issue, we conducted a randomized controlled trial among 1739 smallholder farmers in Malawi to estimate the impact of two key post-harvest constraints, lack of appropriate storage technology and commitment issues, on farmers' legume storage and sales decisions. The treated groups received (i) an improved storage technology in the form of two hermetic (airtight) bags, (ii) the same improved storage technology under the condition that …

Examining Dimensionality And Validity Of The Academic Integrity Survey Instrument, Zhidong Zhang, Luis Garcia

Teaching and Learning Faculty Publications

Dimensional reduction is one of the methods to ensure the quality of a questionnaire. This study examined two methods to reduce the dimension of the questionnaire: multidimensional scaling (MDS) and exploratory factor analysis (EFA). The questionnaire, Awareness of Academic Dishonesty consists of 30 questions. Participants included 110 college students. Multidimensional scaling analysis reduced the multidimensions to essentially two dimensions. The exploratory factor analysis reduced the multidimensions to three dimensions. MDS allowed the researchers to evaluate the questionnaire items by looking at the similarities of these data points. EFA provided an alternative thought about the construct of the questionnaire.

The Low Electability Of Women Legislative Candidates In Gender-Friendly Constituencies In Banten, Amilia Ulfaningrum, Sri Lestari Wahyuningroem, Anwar Ilmar

Jurnal Politik

Tulisan ini mengkaji fenomena rendahnya elektabilitas perempuan di Daerah Pemilihan Banten III pada Pemilihan Umum Legislatif tahun 2019. Daerah ini memiliki karakter pemilih rasional dan ramah gender, namun karakter tersebut ternyata tidak memberi pengaruh terhadap elektabilitas perempuan untuk menjadi anggota parlemen. Kajian-kajian tentang elektabilitas perempuan umumnya menggunakan pendekatan supply-demand untuk menjelaskan elektabilitas perempuan untuk meraih posisi-posisi politik. Kami menemukan bahwa pendekatan ini saja tidak cukup untuk menjelaskan permasalahan yang kami angkat. Hal ini karena analisis suppy-demand hanya memotret kondisi obyektif yang, dalam analisis gender, terjadi di banyak tempat di seluruh dunia saat perempuan tidak selalu dalam posisi lemah. Dengan menggunakan …

Formation Of Local Elite Power Base In Local Politics: “The Emerging” And “The Surviving”, Muhtar Haboddin, La Ode Machdani Afala

Jurnal Politik

Many recent studies show the development of an increasingly diverse elite characterized by the emergence of a new elite and, on the other hand, the collapse of the old elite. However, these studies mainly infer democratic political change as an explanatory factor. This article takes a different standpoint to explain why some local elites collapse, survive, and emerge as new elites. Specifically, this article describes the formation of the elite resource base and its accumulation by emphasizing the perspective of social changes. Resources become the basis of power that determines the position of the elite in society and the political …

Can Grid-Tied Solar Photovoltaics Lead To Residential Heating Electrification? A Techno-Economic Case Study In The Midwestern U.S., Nelson Sommerfeldt, Joshua M. Pearce

Michigan Tech Publications, Part 1

This study aims to quantify the techno-economic potential of using solar photovoltaics (PV) to support heat pumps (HP) towards the replacement of natural gas heating in a representative North American residence from a house owner's point of view. For this purpose, simulations are performed on: (1) a residential natural gas-based heating system and grid electricity, (2) a residential natural gas-based heating system with PV to serve the electric load, (3) a residential HP system with grid electricity, and (4) a residential HP+PV system. Detailed descriptions are provided along with a comprehensive sensitivity analysis for identifying specific boundary conditions that enable …

Hawc Detection Of A Tev Halo Candidate Surrounding A Radio-Quiet Pulsar, A. Albert, R. Alfaro, J. C. Arteaga-Velázquez, H. A. Ayala Solares, E. Belmont-Moreno, T. Capistrán, A. Carramiñana, S. Casanova, J. Cotzomi, S. Coutiño De León, E. De La Fuente, C. De León, R. Diaz Hernandez, M. A. Duvernois, J. C. Díaz-Vélez, C. Espinoza, K. L. Fan, N. Fraija, K. Fang, J. A. García-González, F. Garfias, A. Jardin-Blicq, M. M. González, J. A. Goodman, J. P. Harding, S. Hernandez, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, V. Joshi, Et. Al.

Michigan Tech Publications, Part 1

Extended very-high-energy (VHE; 0.1-100 TeV) γ-ray emission has been observed around several middle-aged pulsars and referred to as “TeV halos.” Their formation mechanism remains under debate. It is also unknown whether they are ubiquitous or related to a certain subgroup of pulsars. With 2321 days of observation, the High Altitude Water Cherenkov (HAWC) Gamma-Ray Observatory detected VHE γ-ray emission at the location of the radio-quiet pulsar PSR J0359+5414 with >6σ significance. By performing likelihood tests with different spectral and spatial models and comparing the TeV spectrum with multiwavelength observations of nearby sources, we show that this excess is consistent with …

Multicollinearity Applied Stepwise Stochastic Imputation: A Large Dataset Imputation Through Correlation‑Based Regression, Benjamin D. Leiby, Darryl K. Ahner

Faculty Publications

This paper presents a stochastic imputation approach for large datasets using a correlation selection methodology when preferred commercial packages struggle to iterate due to numerical problems. A variable range-based guard rail modification is proposed that benefits the convergence rate of data elements while simultaneously providing increased confidence in the plausibility of the imputations. A large country conflict dataset motivates the search to impute missing values well over a common threshold of 20% missingness. The Multicollinearity Applied Stepwise Stochastic imputation methodology (MASS-impute) capitalizes on correlation between variables within the dataset and uses model residuals to estimate unknown values. Examination of the …

Benchmarking The Generalizability Of Brain Age Models: Challenges Posed By Scanner Variance And Prediction Bias, Robert J Jirsaraie, Tobias Kaufmann, Vishnu Bashyam, Guray Erus, Joan L Luby, Lars T Westlye, Christos Davatzikos, Deanna M Barch, Aristeidis Sotiras

2020-Current year OA Pubs

Machine learning has been increasingly applied to neuroimaging data to predict age, deriving a personalized biomarker with potential clinical applications. The scientific and clinical value of these models depends on their applicability to independently acquired scans from diverse sources. Accordingly, we evaluated the generalizability of two brain age models that were trained across the lifespan by applying them to three distinct early-life samples with participants aged 8-22 years. These models were chosen based on the size and diversity of their training data, but they also differed greatly in their processing methods and predictive algorithms. Specifically, one brain age model was …

Indigenous Spaces, Kerri J. Malloy

Faculty Research, Scholarly, and Creative Activity

In this chapter, the use of memory by Indigenous activists and movements in North America to unsettle the status quo by bringing attention to a contested past is reviewed to demonstrate how memory activism has become an integral component of the Indigenous rights movement of the twenty-first century. Centered on awaking the memory of settler-colonial society to unsettle the dominant narrative that pervades the understanding of Indigenous peoples as something of the past serves to spark the settler-colonial state's remembrance that Indigenous people are of the present. Acknowledging the past by honoring the promises that were made undermines the historical …

2021 Rmap Non-Residential Parcels Data Summary Report Silver Bow Creek/Butte Area Npl Site Bpsou, Environmental Standards, Inc., Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

On The Architecture Of Collaboration In Inter-Organizational Natural Resource Management Networks, Gordon M. Hickey, Evelyn Roozee, Remko Voogd, Jasper R. De Vries, Antonia Sohns, Dongkyu Kim, Owen Temby

School of Earth, Environmental, & Marine Sciences Faculty Publications

This paper reviews the architecture of collaboration that exists within inter-organizational natural resource management (NRM) networks. It presents an integrative conceptual framework designed to help operationalize the multi-level interactions that occur between different dimensions of trust, risk perception, and control as key concepts in inter-organizational collaboration. The objective is to identify and justify a series of propositions considered suitable for assessing inter-organizational NRM network collaboration through empirical work. Such an integrative conceptualization goes beyond the existing trust scholarship related to collaborative NRM, and, we argue, offers a useful starting point for further exploring some of the ‘inner’ social dynamics affecting …

Elevated Estuary Water Temperature Drives Fish Gut Dysbiosis And Increased Loads Of Pathogenic Vibrionaceae, Alessandra L. Suzzi, Michael Stat, Troy F. Gaston, Nachshon Siboni, Nathan L. R. Williams, Justin R. Seymour, Megan J. Huggett

Research outputs 2022 to 2026

Marine water temperatures are increasing globally, with eastern Australian estuaries warming faster than predicted. There is growing evidence that this rapid warming of coastal waters is increasing the abundance and virulence of pathogenic members of the Vibrionaceae, posing a significant health risk to both humans and aquatic organisms. Fish disease, notably outbreaks of emerging pathogens in response to environmental perturbations such as heatwaves, have been recognised in aquaculture settings. Considerably less is known about how rising sea surface temperatures will impact the microbiology of wild fish populations, particularly those within estuarine systems that are more vulnerable to warming. We used …

Disruption Of The Atxn1-Cic Complex Reveals The Role Of Additional Nuclear Atxn1 Interactors In Spinocerebellar Ataxia Type 1, Stephanie L Coffin, Mark A Durham, Larissa Nitschke, Eder Xhako, Amanda M Brown, Jean-Pierre Revelli, Esmeralda Villavicencio Gonzalez, Tao Lin, Hillary P Handler, Yanwan Dai, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Roy V Sillitoe, Harry T Orr, Huda Y Zoghbi

Faculty, Staff and Students Publications

Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative disease in that it is caused by a mutation in a broadly expressed protein, ATXN1; however, only select populations of cells degenerate. The interaction of polyglutamine-expanded ATXN1 with the transcriptional repressor CIC drives cerebellar Purkinje cell pathogenesis; however, the importance of this interaction in other vulnerable cells remains unknown. Here, we mutated the 154Q knockin allele of Atxn1154Q/2Q mice to prevent the ATXN1-CIC interaction globally. This normalized genome-wide CIC binding; however, it only partially corrected transcriptional and behavioral phenotypes, suggesting the involvement of additional factors in disease pathogenesis. Using unbiased …

Cxcr4 Expression Is Associated With Proneural-To-Mesenchymal Transition In Glioblastoma, A Basit Khan, Sungho Lee, Akdes Serin Harmanci, Rajan Patel, Khatri Latha, Yuhui Yang, Anantha Marisetty, Hyun-Kyoung Lee, Amy B Heimberger, Gregory N Fuller, Benjamin Deneen, Ganesh Rao

Faculty, Staff and Students Publications

Glioblastoma (GBM) is the most common primary intracranial malignant tumor and consists of three molecular subtypes: proneural (PN), mesenchymal (MES) and classical (CL). Transition between PN to MES subtypes (PMT) is the glioma analog of the epithelial-mesenchymal transition (EMT) in carcinomas and is associated with resistance to therapy. CXCR4 signaling increases the expression of MES genes in glioma cell lines and promotes EMT in other cancers. RNA sequencing (RNAseq) data of PN GBMs in The Cancer Genome Atlas (TCGA) and secondary high-grade gliomas (HGGs) from an internal cohort were examined for correlation between CXCR4 expression and survival as well as …

Svep1 Is An Endogenous Ligand For The Orphan Receptor Pear1, Jared S Elenbaas, Upasana Pudupakkam, Katrina J Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C Lee, Kendall H Burks, Junedh M Amrute, Robert P Mecham, Carmen M Halabi, Arturo Aliso, Jorge Di Paola, Nathan O Stitziel

2020-Current year OA Pubs

Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an extracellular matrix protein that causally promotes vascular disease and associates with platelet reactivity in humans. Here, using a human genomic and proteomic approach, we identify a high affinity, disease-relevant, and potentially targetable interaction between SVEP1 and the orphan receptor Platelet and Endothelial Aggregation Receptor 1 (PEAR1). This interaction promotes PEAR1 phosphorylation and disease associated AKT/mTOR signaling in vascular cells and platelets. Mice lacking SVEP1 have reduced platelet activation, and exogenous SVEP1 induces PEAR1-dependent activation of platelets. SVEP1 and PEAR1 causally and concordantly relate to platelet …

Bacterial Outer Membrane Vesicles Promote Lung Inflammatory Responses And Macrophage Activation Via Multi-Signaling Pathways, Sunhyo Ryu, Kareeman Ni, Chenghao Wang, Ayyanar Sivanantham, Jonathon M. Carnino, Hong-Long Ji, Yang Jin

School of Medicine Faculty Publications and Presentations

Emerging evidence suggests that Gram-negative bacteria release bacterial outer membrane vesicles (OMVs) and that these play an important role in the pathogenesis of bacterial infection-mediated inflammatory responses and organ damage. Despite the fact that scattered reports have shown that OMVs released from Gram-negative bacteria may function via the TLR2/4-signaling pathway or induce pyroptosis in macrophages, our study reveals a more complex role of OMVs in the development of inflammatory lung responses and macrophage pro-inflammatory activation. We first confirmed that various types of Gram-negative bacteria release similar OMVs which prompt pro-inflammatory activation in both bone marrow-derived macrophages and lung alveolar macrophages. …

Graphical Models In Reconstructability Analysis And Bayesian Networks, Marcus Andrew Harris

Dissertations and Theses

This research focuses on the investigation of two machine learning methodologies, Reconstructability Analysis (RA) and Bayesian Networks (BN). Both methods are probabilistic graphical modeling (PGM) methodologies. RA was developed in the systems community and has applications including time-series analysis, classification, decomposition, compression, pattern recognition, prediction, control, and decision analysis. BNs have origins in path models and have applications similar to those of RA. BNs are another graphical modeling approach for data modeling that is closely related to RA; where BN overlaps RA the two methods are equivalent, but RA and BN each has distinctive features absent in the other methodology. …

Spontaneous Coronary Artery Dissection Complicated By Left Ventricular Free Wall Rupture In Turner Syndrome, Brendan F Caprio, Kunal Kotkar, Alan Zajarias, Alan C Braverman

2020-Current year OA Pubs

A 38-year-old with Turner syndrome presented with acute myocardial infarction due to multivessel spontaneous coronary artery dissection (SCAD) complicated by left ventricular free wall rupture. Conservative management for SCAD was pursued. She underwent sutureless repair for an oozing-type left ventricular free wall rupture. SCAD has not been previously reported in Turner syndrome. (

Fmr1 Mutation Alters The Early Development Of Sensory Coding And Hunting And Social Behaviors In Larval Zebrafish, Shuyu I Zhu, Michael H Mccullough, Zac Pujic, Jordan Sibberas, Biao Sun, Thomas Darveniza, Bianca Bucknall, Lilach Avitan, Geoffrey J Goodhill

2020-Current year OA Pubs

Autism spectrum disorders (ASDs) are developmental in origin; however, little is known about how they affect the early development of behavior and sensory coding. The most common inherited form of autism is Fragile X syndrome (FXS), caused by a mutation in

Developmental Programming: Adverse Sexually Dimorphic Transcriptional Programming Of Gestational Testosterone Excess In Cardiac Left Ventricle Of Fetal Sheep, Venkateswaran Ramamoorthi Elangovan, Nadia Saadat, Adel Ghnenis, Vasantha Padmanabhan, Arpita K Vyas

2020-Current year OA Pubs

Adverse in-utero insults during fetal life alters offspring's developmental trajectory, including that of the cardiovascular system. Gestational hyperandrogenism is once such adverse in-utero insult. Gestational testosterone (T)-treatment, an environment of gestational hyperandrogenism, manifests as hypertension and pathological left ventricular (LV) remodeling in adult ovine offspring. Furthermore, sexual dimorphism is noted in cardiomyocyte number and morphology in fetal life and at birth. This study investigated transcriptional changes and potential biomarkers of prenatal T excess-induced adverse cardiac programming. Genome-wide coding and non-coding (nc) RNA expression were compared between prenatal T-treated (T propionate 100 mg intramuscular twice weekly from days 30 to 90 …

The Nazis, The Vatican, And The Jews Of Rome, Patrick J. Gallo

Purdue University Press Books

On October 16, 1943, the Jews of Rome were targeted for arrest and deportation. The Nazis, the Vatican, and the Jews of Rome examines why—and more importantly how—it could have been avoided, featuring new evidence and insight into the Vatican’s involvement. At the time, Rome was within reach of the Allies, but the overwhelming force of the Wehrmacht, Gestapo, and SS in Rome precluded direct confrontation. Moral condemnations would not have worked, nor would direct confrontation by the Italians, Jewish leadership, or even the Vatican.

Gallo underscores the necessity of determining what courses of actions most likely would have spared …

Optimization Of Sniff Nasal Inspiratory Pressure (Snip) Measurement Methodology In Healthy Subjects., M Subhan

School of Biomedical Sciences

Background Maximal inspiratory pressure (MIP) is currently the most commonly used measure for respiratory muscle strength (RMS) estimation, however, requires significant effort. Falsely low values are therefore common, especially in fatigue-prone subjects, such as neuromuscular disorder patients. In contrast, sniff nasal inspiratory pressure (SNIP) requires a short, sharp sniff; this is a natural manoeuvre, decreasing required effort. Consequently, it has been suggested that use of SNIP could confirm the accuracy of MIP measurements. However, no recent guidelines regarding the optimal method of SNIP measurement exist, and varied approaches have been described. Objectives We compared SNIP values from three conditions, namely …

Named Entity Recognition From Biomedical Text, Maged Guirguis

Theses and Dissertations

As vast amounts of unstructured data are becoming available digitally, computer-based methods to extract relevant and meaningful information are needed. Named entity recognition (NER) is the task of identifying text spans that mention named entities, and to classify them into predefined categories. Despite the existence of numerous and well-versed NER methods, the bio-medical domain remains under-studied. The objective of this research is to identify an efficient technique for NER tasks from biomedical data. This is achieved by investigating using deep learning technologies namely pre-trained BERT [1] model and its variances SciBERT [2] and BioBERT [3]. Preprocessing the data before passing …

Investigating The Feasibility Of Creating A Disease Registry In Egypt: A Case Study Of Dementia, Shimaa Adel Heikal

Theses and Dissertations

The increased interest in evidence-based medicine led to the emergence of disease registries worldwide to help tackle the impact of chronic diseases by providing accurate data on several aspects of the disease care process. Age-associated diseases, particularly dementia, are growing worldwide with several implications and increased economic burden, especially in lower-income countries. In Egypt, there is a lack of accurate dementia prevalence and statistics data which hinders the establishment of appropriate disease management and care strategies. A national dementia registry would provide a massive valuable source of patient data that will significantly advance the disease management strategies and quality of …

Invisibility And Dis-Identification Of Algerian Women: Feminist Jurisprudence Eyes On The Legal Provisions Related To Personal Status And Criminal, Sophia Lina Meziane

Theses and Dissertations

Much of the debate around women’s rights in legal systems focuses on the increase of protection as a legal mechanism for approaching and guaranteeing gender equality. Yet, what extensive or comprehensive analysis has been done on how effective such laws are when applied? This thesis discusses the extent to which a feminist legal theory, separate and distinct from the patriarchal legal system, can demonstrate how an Islamic or Napoleonic order is conceptually another male rationality. While one could possibly identify inefficiencies of laws proclaiming equality and protection for women, the context of the question is inevitably entrenched in the very …

The Making And Unmaking Of Urban Citizenship In The Maspero Triangle, Nadine Abd El Razek

Theses and Dissertations

Cairo is undergoing a moment of sharpened exclusion and inclusion, with the city’s residents of informal settlements disproportionately experiencing displacement and abrupt interruptions to their social fabric to make way for investment opportunities. In pursuit of achieving the status of a global city, the Egyptian state has effectively widened its practice of structural violence, in order to accumulate capital through dispossession. In the process of doing so, the state has problematized the contested status of urban citizenship, disenfranchising the urban dwellers of Cairo from their right to the city. Following the temporal shifts in the negotiation for urban citizenship, the …

On Income Inequality And Poverty In Egypt: Is Prosperity Immoral?, Mohamed Karim Lotfy Abdelkhalek

Theses and Dissertations

There are varying perspectives on, and divergent solutions to, the phenomena of income inequality and poverty. There seems to be polarizing views on both of these sensitive topics. One side of the argument believes income inequality should in itself be mitigated through redistribution measures, while the other argues that this should not be the focus of policy makers, as it deters them from facing the more pressing issue facing society – which is absolute poverty. The relationship between income inequality, poverty, and citizen well-being in Egypt is one that warrants further research, and this paper aims to fill this lacuna. …

Biogas Combustion Characteristics In A Concentric Flow Slot Burner: Effects Of Co2 Concentration On Stability And Flame Structure, Maged Kiriakos

Theses and Dissertations

Biogas combustion is affected by the concentration of carbon dioxide. The successful applications of Biogas as a sustainable renewable alternative fuel produced from waste depend on its combustion stability, heat release, and pollution level. The aim of the current study is to apply new combustion technology and study the stability and combustion characteristics of natural gas with different percentages of carbon dioxide from 0 to 40% simulating biogas fuel. The stability characteristics and the temperature profiles of turbulent planar flames at different levels mixture inhomogeneity are investigated and presented in this work. The flames are created in a newly developed …