Digital Commons Network^™

Perusall—An Interactive Tool To Facilitate Online Reading And Discussions, Mai P. Trinh, Sophia R. Thomas, Tejal Wagadia, Christine V. Williams

Management Faculty Publications

No abstract provided.

Implementing Commercial Inverse Design Tools For Compact, Phase-Encoded, Plasmonic Digital Logic Devices, Michael Efseaff, Kyle Wynne, Krishna Narayan, Mark C. Harrison

Engineering Faculty Articles and Research

Numerical simulations have become an essential design tool in the field of photonics, especially for nanophotonics. In particular, 3D finite-difference-time-domain (FDTD) simulations are popular for their powerful design capabilities. Increasingly, researchers are developing or using inverse design tools to improve device footprints and performance. These tools often make use of 3D FDTD simulations and the adjoint optimization method. We implement a commercial inverse design tool with these features for several plasmonic devices that push the boundaries of the tool. We design a logic gate with complex design requirements as well as a y-splitter and waveguide crossing. With minimal code changes, …

Student Life E-Newsletter March 20, 2023, Seattle University School Of Law Student Life

Student Life E-Newsletters

No abstract provided.

Brigham City Corporation, Third-Party Defendant / Appellant, V. Paul B. Bywater, Third-Party Plaintiff / Appellee : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

No abstract provided.

Biomarker Metabolite Discovery For Pancreatic Cancer Using Machine Learning, Immanuelle Kezia, Linda Erlina, Aryo Tedjo, Fadilah Fadilah

Indonesian Journal of Medical Chemistry and Bioinformatics

Pancreatic cancer is one of the deadliest cancers in the world. This cancer is caused by multiple factors and mostly detected at late stadium. Biomarker is a marker that can identify some diseases very specific. For pancreatic cancer, biomarker has been recognized using blood sample known as liquid biopsy, breath, pancreatic secret, and tumor marker CA19-9. Those biomarkers are invasive, so we want to identify the disease using a very convenient method. Metabolite is product from cell metabolism. Metabolites can become a biomarker especially from difficult diseases. In this paper, we want to find biomarker from metabolite using machine learning …

New Embodiments Of Ancient Wisdom: How Green Spiritual Practices Of Simplicity Can Meaningfully Integrate Faith And Environmental Justice Among Emerging Adults, Falon Barton

DMin Project Theses

This March 2024 Doctor of Ministry Project thesis at Lipscomb University explores how green spiritual practices of simplicity provide opportunities for spiritual formation and missional participation, especially for emerging adults. This project synthesizes the biblical and theological foundations for creation care, overviews the sociology of emerging adulthood, offers a framework for Christian simplicity, and investigates how green spiritual practices of simplicity impact the lived experiences of average followers of Jesus. Through interviews with 20 participants between the ages of 18 and 35, this study outlines what green spiritual practices of simplicity are and offers an analysis of themes that demonstrate …

Mmu: 03/20/23–03/26/23, Student Bar Association

Monday Morning Update

This Week @ NDLS

Mass Times

Commons Daily Menu

General Announcements

NDLS Faculty & Staff Spotlights: Patti McLaughlin

Ask a 3L: Josh Lacoste

Jackie's Corner

Hemangioblastoma With Late Leptomeningeal Metastasis: A Case Report, Spencer J. Poiset, Aneesh Reddy, Catherine M. Tucker, Lawrence C. Kenyon, Kevin D. Judy, Wenyin Shi

Department of Radiation Oncology Faculty Papers

BACKGROUND: Hemangioblastoma of the central nervous system is an uncommon benign neoplasm, with about 25% of cases in patients with von Hippel-Lindau disease. The incidence of metastasis is rare, particularly in patients without von Hippel-Lindau disease. We report a case of hemangioblastoma with leptomeningeal dissemination as a late recurrence.

CASE PRESENTATION: A 65-year-old Caucasian man with a history of World Health Organization grade I hemangioblastoma of the cerebellar vermis underwent gross total resection in 1997. In early 2018, he developed intracranial recurrences with diffuse leptomeningeal disease of the entire spine. The patient underwent resection of intracranial recurrence, followed by palliative …

Dna Damage Response-Related Proteins Are Prognostic For Outcome In Both Adult And Pediatric Acute Myelogenous Leukemia Patients: Samples From Adults And From Children Enrolled In A Children's Oncology Group Study, Stefan E Hubner, Eduardo S De Camargo Magalhães, Fieke W Hoff, Brandon D Brown, Yihua Qiu, Terzah M Horton, Steven M Kornblau

Faculty, Staff and Student Publications

The survival of malignant leukemic cells is dependent on DNA damage repair (DDR) signaling. Reverse Phase Protein Array (RPPA) data sets were assembled using diagnostic samples from 810 adult and 500 pediatric acute myelogenous leukemia (AML) patients and were probed with 412 and 296 strictly validated antibodies, respectively, including those detecting the expression of proteins directly involved in DDR. Unbiased hierarchical clustering identified strong recurrent DDR protein expression patterns in both adult and pediatric AML. Globally, DDR expression was associated with gene mutational statuses and was prognostic for outcomes including overall survival (OS), relapse rate, and remission duration (RD). In …

Three-Year Update Of Tisagenlecleucel In Pediatric And Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia In The Eliana Trial., Theodore W. Laetsch, Shannon L. Maude, Susana Rives, Hidefumi Hiramatsu, Henrique Bittencourt, Peter Bader, André Baruchel, Michael Boyer, Barbara De Moerloose, Muna Qayed, Jochen Buechner, Michael A. Pulsipher, Douglas Myers, Heather E. Stefanski, Paul L. Martin, Eneida Nemecek, Christina Peters, Gregory Yanik, Seong Lin Khaw, Kara L. Davis, Joerg Krueger, Adriana Balduzzi, Nicolas Boissel, Ranjan Tiwari, Darragh O'Donovan, Stephan A. Grupp

Manuscripts, Articles, Book Chapters and Other Papers

In the primary analysis of the global phase II ELIANA trial (ClinicalTrials.gov identifier: NCT02435849), tisagenlecleucel provided an overall remission rate of 81% in pediatric and young adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL), with 59% of responders remaining relapse-free at 12 months. Here, we report an update on efficacy, safety, and patient-reported quality of life in 79 pediatric and young adult patients with R/R B-ALL following a median follow-up of 38.8 months. The overall remission rate was 82%. The median event-free survival was 24 months, and the median overall survival was not reached. Event-free …

Multicenter Phase Ii Trial Of The Wee1 Inhibitor Adavosertib In Refractory Solid Tumors Harboring, Siqing Fu, Shuyang Yao, Yuan Yuan, Rebecca A Previs, Anthony D Elias, Richard D Carvajal, Thomas J George, Ying Yuan, Lihou Yu, Shannon N Westin, Yan Xing, Ecaterina E Dumbrava, Daniel D Karp, Sarina A Piha-Paul, Apostolia M Tsimberidou, Jordi Rodon Ahnert, Naoko Takebe, Karen Lu, Khandan Keyomarsi, Funda Meric-Bernstam

Faculty, Staff and Student Publications

PURPOSE: Preclinical cancer models harboring

PATIENTS AND METHODS: Patients aged ≥ 18 years with measurable disease and refractory solid tumors harboring

RESULTS: Thirty patients were enrolled. The median follow-up duration was 9.9 months. Eight patients had partial responses (PRs), and three had stable disease (SD) ≥ 6 months, with an ORR of 27% (95% CI, 12 to 46), a SD ≥ 6 months/PR rate of 37% (95% CI, 20 to 56), a median progression-free survival duration of 4.1 months (95% CI, 1.8 to 6.4), and a median overall survival duration of 9.9 months (95% CI, 4.8 to 15). Fourteen patients …

Assessment And Contrast The Sustainable Growth Of Various Road Transport Systems Using Intelligent Neutrosophic Multi-Criteria Decision-Making Model, Nada Nabeeh

Sustainable Machine Intelligence Journal

This study analyses the elements and approaches to creating sustainable transport systems, with a focus on road travel. The study examines the environmental and economic aspects of sustainable road transport and stresses the need to curb carbon emissions, boost energy efficiency, clean the air, ensure everyone has easy access to transport, and think about societal goals as a whole. Important considerations including environmental effect, energy efficiency, legislative frameworks, and economic impact are highlighted in the study. The MCDM model is used as a complexity instrument to strike a balance between competing objectives and criteria. This research may help stakeholders use …

Protecting Iot Devices From Botnet Threats: A Federated Machine Learning Solution, Ahmed A. Metwaly, Ibrahim Elhenawy

Sustainable Machine Intelligence Journal

The proliferation of Internet of Things (IoT) devices has brought unprecedented convenience to our lives, but it has also opened the door to new security challenges. One of the most pressing threats in the IoT landscape is the proliferation of BotNets, which can compromise and control a multitude of devices for malicious purposes. In this paper, we propose a novel approach to address this issue: a Federated Machine Learning Solution for BotNet detection in IoT environments. Our method leverages the collective intelligence of distributed IoT devices while respecting privacy constraints, ensuring that sensitive data never leaves the device. We present …

A First-In-Human Phase I Study Of Milademetan, An Mdm2 Inhibitor, In Patients With Advanced Liposarcoma, Solid Tumors, Or Lymphomas, Mrinal M Gounder, Todd M Bauer, Gary K Schwartz, Amy M Weise, Patricia Lorusso, Prasanna Kumar, Ben Tao, Ying Hong, Parul Patel, Yasong Lu, Arnaud Lesegretain, Vijaya G Tirunagaru, Feng Xu, Robert C Doebele, David S Hong

Faculty, Staff and Student Publications

Purpose: This study evaluated the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of milademetan, a small-molecule murine double minute-2 (MDM2) inhibitor, in patients with advanced cancers.

Patients and methods: In this first-in-human phase I study, patients with advanced solid tumors or lymphomas received milademetan orally once daily as extended/continuous (days 1-21 or 1-28 every 28 days) or intermittent (days 1-7, or days 1-3 and 15-17 every 28 days) schedules. The primary objective was to determine the recommended phase II dose and schedule. Secondary objectives included tumor response according to standard evaluation criteria. Predefined analyses by tumor type were performed. Safety and …

About Lpa, Latvian Privatization Agency

Documents

No abstract provided.

The Effect Of Corruption Control On Efficiency Spillovers, Levent Kutlu, Xi Mao

School of Economics and Finance Faculty Publications

We examine the effect of corruption control on efficiency and its implications for efficiency spillovers by a stochastic frontier model. Our dataset covers 102 countries from 1996 to 2014. We find a positive relationship between corruption control and efficiency. If neighboring countries have difficulty in handling corruption, the country would be negatively affected by its neighbors' corruption through efficiency spillovers. We then compare the efficiency differences across countries for three time periods: 1996–2002, 2002–2008, and 2008–2014. On average, technical efficiencies slightly increased in the second period compared to the first period. In the third period, the efficiencies declined, particularly in …

Patterns And Processes In The History Of Body Size In Turritelline Gastropods, Jurassic To Recent, Carlie Pietsch, Michael Gigliotti, Brendan M. Anderson, Warren D. Allmon

Faculty Research, Scholarly, and Creative Activity

Body size is an important trait with implications for energy use and ecology as well as generation time and evolutionary rates. Turritelline gastropods are widely distributed through geologic time and space, making them an excellent group for evaluating macroevolutionary patterns. To evaluate the pattern of body-size change in turritelline gastropods, we compiled a dataset of shell lengths of 316 species of turritelline gastropods spanning the Jurassic to Recent. Type specimens were almost always significantly larger than specimen distributions from the same species. We found that turritelline gastropod size was inversely correlated with latitude, a trend likely driven by the Neogene-Recent …

Head Movement Behaviors In Various Communication Environments, Angkana Lertpoompunya

USF Tampa Graduate Theses and Dissertations

In a complex environment with only a single-source speech target, modern hearing aids can improve signal-to-noise ratios (SNRs) by using directional microphones, and consequently, improve speech intelligibility. However, in many realistic listening situations where there are multiple sound sources, especially in a turn-taking conversation, improving the SNRs in one location may come at a cost of another equally important location. Critically, the hearing aid user is also unlikely to retain a static head orientation to which the hearing aids reference in these complex environments. For this reason, modern premium hearing aids are now equipped with motion sensors (e.g., accelerometers) to …

Rhodium‐Catalyzed Asymmetric Arylation Of Cyclobutenone Ketals, David Egea-Arrebola, F Wieland Goetzke, Stephen P Fletcher

Faculty, Staff and Student Publications

Complex cyclobutanes are important motifs in both bioactive molecules and natural products, yet their enantioselective preparation has not been widely explored. In this work, we describe rhodium-catalyzed enantioselective additions of aryl and vinyl boronic acids to cyclobutenone ketals. This transformation involves enantioselective carbometalation to give cyclobutyl-rhodium intermediates, followed by β-oxygen elimination to afford enantioenriched enol ethers. Overall, this addition serves as a surrogate for Rh-catalyzed 1,4-additions to cyclobutenone.

Scurvy, Abnormal Mri, And Gelatinous Bone Marrow In An Adolescent With Avoidant Restrictive Food Intake Disorder, Ginny Claire Kim, Asha M Davidson, Rebecca M Beyda, Mona A Eissa

Faculty, Staff and Student Publications

BACKGROUND: Although medical literature describes pediatric scurvy as "rare", a growing number of case reports suggests otherwise. Patients often undergo costly and unnecessary workup due to unfamiliarity with the presentation of scurvy. This case report further supports the small yet growing literature documenting scurvy and its manifestations in patients with eating disorders.

CASE PRESENTATION: A 15-year-old female presented to the emergency department with bilateral knee and ankle swelling and pain in the setting of chronic lower limb rash and BMI of 16.3. For years, she had restricted her diet to carbohydrates. Exam showed perifollicular petechial hemorrhagic rash with corkscrew hairs, …

A Longitudinal Study Of The Effect Of Individual And Socio-Cultural Factors On Students’ Creativity, Hye-Sook Park, Seokmin Kang, Sungyeun Kim

Teaching and Learning Faculty Publications

This longitudinal study investigated how characteristics of individual and social relationships affect Korean students’ creativity development. Fifth graders (male: 3,623, female: 3,701) from 242 schools in Korea were followed annually from their 5th to 9th grades (indicating from the 5th elementary school grade to the 3rd middle school grade in the Korean school system). Exploratory factor analysis, internal consistency reliability (coefficient alpha), confirmatory factor analysis, and two-level growth model methods were performed. We investigated all nine constructs and their related items by checking metric and scalar invariance assumptions. When the measurement invariance assumptions were satisfied, we used the mean of …

Dental Board Of California, Dimitri A. Davis, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Medical Board Of California, Carter Cordura, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Board Of Pharmacy, Mackenzie Mccoy, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Board Of Registered Nursing, Carter Cordura, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Veterinary Medical Board, Dimitri A. Davis, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Contractors State License Board, Lauren Holappa, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Bureau Of Private Postsecondary Education, Mackenzie Mccoy, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Department Of Insurance, Shiloh Wallack, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.

Public Utilities Commission, Shiloh Wallack, Angela O’Hara

California Regulatory Law Reporter

No abstract provided.