Digital Commons Network^™

Design, Biological Evaluation, And Computer-Aided Analysis Of Dihydrothiazepines As Selective Antichlamydial Agents, Luana Janaína De Campos, Mohamed A. Seleem, Jiachen Feng, Kelly Mari Pires De Oliveira, João Víctor De Andrade Dos Santos, Shivdeep Hayer, Jonathan B. Clayton, Sharvath Kathi, Derek J. Fisher, Scot P. Ouellette, Martin Conda-Sheridan

Department of Food Science and Technology: Faculty Publications

Chlamydia trachomatis (CT) causes the most prevalent sexually transmitted bacterial disease in the United States. The lack of drug selectivity is one of the main challenges of the current antichlamydial pharmacotherapy. The metabolic needs of CT are controlled, among others, by cylindrical proteases and their chaperones (e.g., ClpX). It has been shown that dihydrothiazepines can disrupt CT-ClpXP. Based on this precedent, we synthesized a dihydrothiazepine library and characterized its antichlamydial activity using a modified semi-high-throughput screening assay. Then, we demonstrated their ability to inhibit ClpX ATPase activity in vitro, supporting ClpX as a target. Further, our lead …

Microwave Ablation As A Primary Versus Secondary Treatment For Hepatocellular Carcinoma., Philip Lee, Ajay Makkena, Mohamed Tantawi, Felipe Velasquez-Botero, John R. Eisenbrey, Colette M. Shaw

Department of Radiology Faculty Papers

PURPOSE: The purpose of this study was to analyze and compare the outcomes of percutaneous microwave ablation (MWA) when used as a primary vs. secondary treatment for hepatocellular carcinoma (HCC).

METHODS: The clinical data of 192 patients with HCC treated with MWA between January 2012 and July 2021 were reviewed retrospectively, with 152 patients being treatment naïve (primary treatment) vs. 40 who had residual or recurrent disease following previous trans-arterial chemoembolization or trans-arterial radioembolization (secondary treatment). The primary outcomes were primary technical efficacy, 1- and 3-year local recurrence-free survival (RFS) and overall survival (OS), local recurrence rates, and adverse events. …

20230329: President's Papers (Stewart Smith), 1964-1969, President's Office

Guides to University Archives

These items include materials from the Office of the President at Marshall University from 1964-1969. Items were received in 2023 from former President, Stewart Smith's Son (Fredrick Smith), which includes a binder of letters that was sent to his father when he was ending his presidency at Marshall, among a few other things. Also included is the series of notes taken during the donation, to include a few personal stories of Fred as a child growing up on Marshall's campus. The attached inventory will give a broad overview of what is contained in the collection.

State Of Tennessee Single Audit For The Year Ended June 30, 2022, Tennessee. Comptroller Of The Treasury.

Financial and Compliance Audit Reports

No abstract provided.

Single Audit Report For The Year Ended June 30, 2024, Tennessee. Comptroller Of The Treasury.

Financial and Compliance Audit Reports

No abstract provided.

The Shared Experiences Of Non-Traditional Groups In Academic Stem Disciplines, Kimberly Luthi

Publications

The results of this effort resulted in the identification of factors that can be used as a conceptual framework for establishing institutional conditions and a work environment across higher education institutions that support women’s advancement and retention in academic appointments of leadership related to STEM disciplines and workplace education. The research considers relevant literature related to current institutional strategies and predictors for women’s success and retention in STEM disciplines. Such an exploration addresses challenges of non-traditional groups, specifically gender inequity issues regarding women’s advancement in STEM.

The Emergence Of A Virus Variant: Dynamics Of A Competition Model With Cross-Immunity Time-Delay Validated By Wastewater Surveillance Data For Covid-19, Bruce Pell, Samantha Brozak, Tin Phan, Fuqing Wu, Yang Kuang

Faculty, Staff and Student Publications

We consider the dynamics of a virus spreading through a population that produces a mutant strain with the ability to infect individuals that were infected with the established strain. Temporary cross-immunity is included using a time delay, but is found to be a harmless delay. We provide some sufficient conditions that guarantee local and global asymptotic stability of the disease-free equilibrium and the two boundary equilibria when the two strains outcompete one another. It is shown that, due to the immune evasion of the emerging strain, the reproduction number of the emerging strain must be significantly lower than that of …

One Health: A Public Health Solution Or Slogan?, Andrew N. Rowan

WellBeing News

One Medicine has now morphed into One Health, but the concept has yet to be wholeheartedly embraced by the medical profession. In 2008, a Commentary in the American Journal of Medicine noted that medical schools, unlike veterinary schools, typically do not emphasize the ecology of zoonotic pathogens despite the estimated 60% of human diseases (and 75% of emerging diseases) originating in animals. The situation may be changing.

By The Grace Of God: The Lived Experience Of Mothering An Infant While Recovering From Chemical Dependency, Kathy R. Higgins

Dissertations

What is it like to mother an infant while recovering from chemical dependency? That question is answered by this research into one of our country's major public health issues. Research and literature related to drug use by women is generally lacking. Both members of the mother-baby dyad begin their relationship in a vulnerable state and are at great risk for problems. The predominant qualitative method used by nurse researchers has been grounded theory. This method results in describing a process; however, understanding the process and its meaning to those who live it every day is required to better deal with …

Integrating Oral Health Care Into Primary Care Well Child Visits: An Interprofessional Model Of Care, Lisa Moravec, Kelly Betts

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Immediate Vs Delayed Feedback In A Progressive Musculoskeletal E-Module Case For Clinical Reasoning Development, Megan Frazee, Krista Gipson, Elizabeth Lyden, Stephanie Langel

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Using Standardized Patient Assessments To Evaluate Effectiveness Of Health Literacy Training Modalities For Professional Students, Shayla Yoachim, Emma Baller, Wendy Zhao

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Evaluation Of A Comprehensive E-Module Of The Male And Female Perineal Pouches And Structures In The Gross Anatomy Dissection, Brittany Clifton, Kimberly Latacha, Megan Brown

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Impact Of Lecture Videos On Academic Performance, Marnie Imhoff, Linsey Donner

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Powerpoint-Free In 2023: Pedagogy Of Augmented Reality Integration In A Cadaver-Based Human Anatomy Curriculum, Ethan Snow, Shawn Magrum, Jaynie Bird

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Using Qr-Code Technology In Medical Education To Foster Health Equity: A Walking Tour About Combating Racism In Medicine, Mark Carter, Jennifer Liu

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Feedback Versus Compliments Versus Both In Suturing And Knot Tying Simulation: A Randomized Controlled Trial, Kelsey Tieken, Grace Kelly, Jessica Maxwell, Michael Visenio, Jannelle Reynolds, Abbey Fingeret

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Health Educators And Academic Leaders (Heal): Program Evaluation Of A Clinical Educator Pathway For Competency-Based Faculty Development (Cbfd), Cory Rohlfsen, Jonathan Hall, Michelle Howell

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

The Design Of An Interprofessional Mock Objective Structured Clinical Examination (Osce) In Preparation For High-Stakes Exams, Mckenzie R. Behrendt, Jessica Semin, Stacy Smallfield

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Efficacy Of 3d Printed Uterus And Silicone Cervix For Medical Education In Learning And Practicing Gynecologic Procedures, Jami Monico, Karen S. Carlson

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

A Comparative Evaluation Of 3d Printed Versus Standard Suture Materials, Thang Nguyen, Benjamin Reinhart, Elizabeth Lyden, Jason Langenfeld

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Teaching Procedural Skills: Beyond "See One, Do One, Teach One", Christopher J. Smith, Jana L. Wardian Phd, Khalid Sahak

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Student Responses To Feedback Versus Affirmation Versus Both In Suturing Skills: A Qualitative Study, Grace Kelly, Kelsey Tieken, Jessica Maxwell, Michael Visenio, Jannelle Reynolds, Abbey Fingeret

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Curriculum Development To Improve Internal Medicine Resident Subspecialty Education, Jay Hawkins, Prasanth Ravipati, Ryan P. Mullane, Troy Plumb, Scott Westphal, Trek Langenhan

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Development Of A Neurally Adjusted Ventilatory Assist (Nava) Education Bundle For Intensive Care Providers, Brianna Brei, Abhineet Sharma, Chelsey Marion, Joseph Novotny, Kara Mickas, Junghyae Lee, Kendra Christensen, Jeffrey D. Salomon

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Building Confidence And Competence: The Effects Of Early Career Coaching And Research Training On Student Research Perspectives, Joseph Kleinsmith, Jayme Dowdall, Michelle Howell Smith, Kristy Carlson

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Enhancing Patient Education With Innovative 3d-Virtual Reality Pelvic Model, Taylor Hedgecock, Jennifer Cera

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Evaluating The Feasibility Of Using A Tele-Mentoring Model In Performing A Two-Point Deep Vein Thrombosis (Dvt) Ultrasound Scan With Novice Sonographers, Thang Nguyen, Cody Bonk, Dalton Nelson, Jared Marx

Innovations in Health Sciences Education Journal

This is a published abstract from the UNMC Spotlight on Scholarship 2023.

Dissemination And Implementation Of A Text Messaging Campaign To Improve Health Disparities Among Im/Migrant Workers, Ellie Cherryhomes, Shannon Guillot-Wright

Faculty, Staff and Student Publications

The use of short message service (SMS) text messaging technology has grown in popularity over the last twenty years, but there is limited data on the design and feasibility of campaigns to reduce work-related injury, particularly among rural workers, non-native English speakers, and illiterate or low-literacy populations. Although there is a critical need for tech equity or 'TechQuity' interventions that reduce injury and enhance the wellbeing of under-reached communities, the barriers and benefits to implementation must be empirically and systematically examined. Thus, our team used D&I science to design and implement an 18-week texting campaign for under-reached workers with a …

Geographic Variations And The Associated Factors In Adherence To And Persistence With Adjuvant Hormonal Therapy For The Privately Insured Women Aged 18-64 With Breast Cancer In Texas, Junghyun Kim, Man S Kim, Suja S Rajan, Xianglin L Du, Luisa Franzini, Tae Gi Kim, Sharon H Giordano, Robert O Morgan

Faculty, Staff and Student Publications

The purpose of this study is to examine the geographical patterns of adjuvant hormonal therapy adherence and persistence and the associated factors in insured Texan women aged 18-64 with early breast cancer. A retrospective cohort study was conducted using 5-year claims data for the population insured by the Blue Cross Blue Shield of Texas (BCBSTX). Women diagnosed with early breast cancer who were taking tamoxifen or aromatase inhibitors (AIs) for adjuvant hormonal therapy with at least one prescription claim were identified. Adherence to adjuvant hormonal therapy and persistence with adjuvant hormonal therapy were calculated as outcome measures. Women without a …