Digital Commons Network^™

Phase Ii Trial Of Neoadjuvant Sitravatinib Plus Nivolumab In Patients Undergoing Nephrectomy For Locally Advanced Clear Cell Renal Cell Carcinoma, Jose A Karam, Pavlos Msaouel, Cara L Haymaker, Surena F Matin, Matthew T Campbell, Amado J Zurita, Amishi Y Shah, Ignacio I Wistuba, Enrica Marmonti, Dzifa Y Duose, Edwin R Parra, Luisa Maren Solis Soto, Caddie Laberiano-Fernandez, Marisa Lozano, Alice Abraham, Max Hallin, Curtis D Chin, Peter Olson, Hirak Der-Torossian, Xiaohong Yan, Nizar M Tannir, Christopher G Wood

Faculty, Staff and Student Publications

Sitravatinib is an immunomodulatory tyrosine kinase inhibitor that can augment responses when combined with programmed death-1 inhibitors such as nivolumab. We report a single-arm, interventional, phase 2 study of neoadjuvant sitravatinib in combination with nivolumab in patients with locally advanced clear cell renal cell carcinoma (ccRCC) prior to curative nephrectomy (NCT03680521). The primary endpoint was objective response rate (ORR) prior to surgery with a null hypothesis ORR = 5% and the alternative hypothesis set at ORR = 30%. Secondary endpoints were safety; pharmacokinetics (PK) of sitravatinib; immune effects, including changes in programmed cell death-ligand 1 expression; time-to-surgery; and disease-free survival …

Combining Granular Aerogels With Additively Manufactured Porous Structures For Broadband Sound Absorption, L. Paige Nobles, Yutong Xue, J Stuart Bolton, Bhisham Sharma

Publications of the Ray W. Herrick Laboratories

Our recent investigation [1] showed that the absorption behavior of granular aerogel agglomerates with average particle diameters less than 50μm is dominated by periodically spaced, high absorption peaks and troughs. While the absorption peaks, especially at lower frequencies, are desirable from an engineering application perspective, overcoming the loss in high frequency performance remains a challenge. Furthermore, the practical application of granular aerogels is limited by the difficulty in handling them. In this work, we propose a new design for a broadband noise absorber achieved by layering the aerogel granules within a 3D printed porous network. The design provides …

Study Of The Impact Of Boundary Conditions On Acoustical Behavior Of Granular Materials And Their Implementation In The Finite Difference Method, Zhuang Mo, Guochenhao Song, Tongyang Shi, J Stuart Bolton

Publications of the Ray W. Herrick Laboratories

Granular materials display significant differences in their acoustical response when tested in a standing wave tube, compared with the behavior of more traditional sound absorbing materials such as fibrous webs and foams. The latter materials can often be modeled as an equivalent fluid with the further assumption that the material properties do not depend on the input signal level. In contrast, the level dependence of the acoustical behavior of granular materials has been observed in measurements of glass bubbles, as reported in previous studies, for example. When the input level is low, the absorption coefficient of the glass bubble stack …

Prediction Of Acoustical Behavior Of Granular Material Stacks As Measured In A Standing Wave Tube By Using A Biot Theory-Based Model, Zhuang Mo, Guochenhao Song, Tongyang Shi, J Stuart Bolton

Publications of the Ray W. Herrick Laboratories

The acoustical behavior of granular materials, such as activated carbon and silica gel, has drawn attention in recent studies, due to their favorable properties such as good low frequency sound absorption. Like other more traditional porous materials, granular materials can also be tested in a standing wave tube for a convenient assessment of their acoustical properties. However, the behavior of granular materials stacked in a standing tube is more complex than that of traditional materials. For example, the response of lightweight glass bubbles reveals a clear dependence on the sound pressure level of the input signal. Also, when tested in …

Identification Of Novel Anti-Amoebic Pharmacophores From Kinase Inhibitor Chemotypes, Lori Ferrins, Melissa J. Buskes, Madison M. Kapteyn, Hannah N. Engels, Suzanne E. Enos, Chenyang Lu, Dana M. Klug, Baljinder Singh, Antonio Quotadamo, Kelly Bachovchin, Westley F. Tear, Andrew E. Spaulding, Katherine C. Forbes, Seema Bag, Mitch Rivers, Catherine Leblanc, Erin Burchfield, Jeremy R. Armand, Rosario Diaz-Gonzalez, Gloria Ceballos-Perez, Raquel Garcia-Hernandez, Guiomar Perez-Moreno, Cristina Bosch-Navarrete, Claudia Gomez-Linan, Luis Miguel Ruiz-Perez, Francisco Gamarro, Dolores Gonzalez-Pacanowska, Miguel Navarro, Kojo Mensa-Wilmot, Michael P. Pollastri, Dennis E. Kyle, Christopher A. Rice

Purdue University Libraries Open Access Publishing Fund

Acanthamoeba species, Naegleria fowleri, and Balamuthia mandrillaris are opportunistic pathogens that cause a range of brain, skin, eye, and disseminated diseases in humans and animals. These pathogenic free-living amoebae (pFLA) are commonly misdiagnosed and have sub-optimal treatment regimens which contribute to the extremely high mortality rates (>90%) when they infect the central nervous system. To address the unmet medical need for effective therapeutics, we screened kinase inhibitor chemotypes against three pFLA using phenotypic drug assays involving CellTiter-Glo 2.0. Herein, we report the activity of the compounds against the trophozoite stage of each of the three amoebae, ranging from …

Improved Distributed Coordination Of Multi-Robot Systems In Unknown Environments, Zhun Cheng

Electrical and Systems Engineering Undergraduate Student Research

Swarm robot control algorithms intend to compute and coordinate the paths of a group of robots, known as a swarm, to perform certain tasks. To cooperate a swarm of robots, constant communication often is needed. However, when the robots are deployed to areas where communication network is unsteady, or unavailable, like underwater, underground, or remote areas. A continuation of the author’s summer research, this semester the multi robot RRT* was improved by using individual rewire processes and recalculating communication point when deemed inaccessible. This allows the planning scheme to be extended into the unknown space.

Performance Evaluation Of Pgm-Free Catalysts In Hydrogen Fuel Cells: Towards Sustainable And Cost-Effective Energy Solutions, Minju Lee

Mechanical Engineering and Materials Science Independent Study

The research presented in this report focuses on evaluating the performance of hydrogen fuel cells using platinum-group-metal (PGM)-free catalysts and optimizing their operation by varying cathode back pressure. The objective was to achieve similar or better performance compared to conventional platinum-based membrane electrode assemblies (MEAs) while reducing the reliance on rare earth materials. A series of experiments were conducted using synthetically fabricated PGM-free MEAs, with results indicating that higher input pressures led to a significant increase in power output, reaching nearly 70% of the performance of the conventional platinum, ruthenium, and carbon-based MEAs. This research contributes to the overall understanding …

Integrative Analysis Of Cell-Free Dna Liquid Biopsy Data, Irfan Alahi

McKelvey School of Engineering Graduate Student Theses & Dissertations

No abstract provided.

Losing And Finding Braj: Commodification And Entrepreneurship In The Sacred Land Of Krishna, Leena Taneja

All Works

Braj is a sacred place revered by Bengali Vaishnavas, followers of the bhakti sect of Vaishnavism, one of four branches of Hindu devotion. Followers of the sect worship the God Krishna, who it is believed manifested in Braj and carried out many divine feats and activities that are imprinted onto the land. Braj today is dotted with thousands of holy shrines, temples and natural places connected to Krishna. Devotees connect to Krishna through the landscape of Braj; it is where the transcendental and the physical realms meet. Braj has been transformed in a multitude of ways with the influx of …

Perception Of Threat And Intent To Harm From Vocal And Facial Cues, James Tompkinson, Mila Mileva, Dominic Watt, Burton A Mike

School of Psychology

What constitutes a “threatening tone of voice”? There is currently little research exploring how listeners infer threat, or the intention to cause harm, from speakers’ voices. Here, we investigated the influence of key linguistic variables on these evaluations (Study 1). Results showed a trend for voices perceived to be lower in pitch, particularly those of male speakers, to be evaluated as sounding more threatening and conveying greater intent to harm. We next investigated the evaluation of multimodal stimuli comprising voices and faces varying in perceived dominance (Study 2). Visual information about the speaker’s face had a significant effect on threat …

Impact Of Social Media On Political Development And Stability In Nigeria, Helen Remilekun Oluleye, Lilian K. Maduagwu, John I Muyiwa Adeniyi, Adamu Baba Musa

Library Philosophy and Practice (e-journal)

Abstract

The invention and rapid advancement of Information and Communication Technologies (ICTs) has attracted considerable attention on the impact of social media on various human development. With the emergence of social media, people around the globe nascent democracies which have started using their online presence to engage in political discussions. This led to the creating of various strategies in ensuring and maintaining political development in Nigeria. This paper aims to discuss how social media impacted on political development and stability in Nigeria. To achieve the afore stated; the meaning of social media is discussed, the concept of political development and …

Final 2023 Residential Metals Abatement Program (Rmap) Park Soil Sampling Field Sampling Plan (Fsp) Submittal #8 [Ramsay Skating Rink, Skyline Park, Butte Vigilante Saddle Club, Butte Country Club, Fairmont Hot Springs, Silver Bow Homes Park, Gloria Dei Lutheran Church, And United Congregational Church], Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Perils Of The Heroine: The Historic Role Of Woman In Comics, Britain Bray

MFA in Illustration & Visual Culture

Now more than ever the comics industry is welcoming diversity in its creators and stories, but with its historically misogynistic past, what legacy are creators inheriting? This essay seeks to explore that history, delving into the various eras of American Comics and how sexism shaped them. From the earliest heroines of the 40s, the ground-breaking feminist indie comics of the 70s, and the rampant female sexualization of the 90s, examples of brilliance and drudgery will be investigated in order to gain a better understanding of how comics became what they are today.

It's A Match: Shaadi.Com, Tinder, And The Fantasy Of Frictionless-Ness, Purvi Rajpuria

MFA in Illustration & Visual Culture

In this essay I carry out case studies of Shaadi.com and Tinder to unpack the cultural principles underlying the apps that shape our interpersonal relationships today. I demonstrate that these apps are grounded in a fantasy of frictionless-ness, or the desire to shield the self from discomfort caused by external factors, and argue that this is a fraught cultural ideal. My analysis reveals that a fantasy of frictionless-ness gives birth to a cultural landscape of rampant subjectivity and tepid morality, which hampers our ability to form deep and meaningful connections with each other. Recognising the flaws of such a fantasy, …

My Kinship With The Trees, C. Daniela Shapiro

MFA in Illustration & Visual Culture

This paper explores facets of patriarchy affecting women and the natural world. The paper suggests a cultivation of allyship and relationality between women and nature due to a shared experience of objectification within patriarchy. The separation of women from nature through origin stories, science, religion, language, and advertisement will be discussed. Examples from the graphic memoir Running without Moving are employed to emphasize this philosophy, including first person accounts.

Prosthetic Traveling Companions, Carrie Keasler

MFA in Illustration & Visual Culture

This essay explores the potential for narrative art (film, literature, comics) to be a transformative experience in the life of the consumer (viewer, reader) through a sensuous, embodied interaction with that work of narrative art. Drawing from film, narrative and comics theory as well as primary sources, I show that there is potential for consumers to engage in reading and viewing in an embodied way that allows them to take on these experiences as new memories, highlighting the ability of art to engage our senses in a manner that is similar to everyday lived experiences. In contrast with some theories …

The Dark House And Its Inhabitants, Emily Bielski

MFA in Illustration & Visual Culture

From the inception of the genre, Gothic horror has been fixated on the domestic space in distress. This essay explores domestic archetypes and roles of the Gothic novel, serving as a “tour of the house”, analyzing the iconography of the dark castle, and how it externalizes and exacerbates the fears and behaviors of its inhabitants. The power dynamic of the household is starkly divided by the expectations and authority of masculine and feminine figures. In turn the “house” becomes a vehicle for the anxieties of the inhabitants—both experienced and inflicted—regarding gender, sexuality, isolation, and abuse. Exploration of the visual and …

Monster Planet Bounty Hunter, Arthur Santoro

MFA in Illustration & Visual Culture

In this paper I will be discussing my personal interest in games and art as well as my experience and process working on my original board game: Monster Planet Bounty Hunter. I will also discuss my visual influences, how I approach making games and why I think games are an important form of art.

Legends Of Light: Crafting Middle Grade Fantasy In The Tradition Of Catholic Philosophy And Medieval Visual Culture, Bernadette Lamb

MFA in Illustration & Visual Culture

This essay promotes the writing and illustrating of middle grade literature that mirrors the wonder-inducing experiences of leafing through an illuminated manuscript and stepping into a Gothic cathedral. An examination of Catholic medieval visual culture moves into a discussion on its underlying philosophy and theology, which are profoundly centered on relational healing and the dignity of the human person. Christian writers including St. Pope John Paul II, C.S. Lewis, J.R.R. Tolkien, Josef Pieper, Madeline L’Engle, Dr. Bob Schuchts, Makoto Fujimura, and Andrew Peterson inform an exploration of mercy, forgiveness, and love as self-gift in the context of illustration and storytelling …

Shambles & Crowley: Autobiographical Fiction In Four Panels, Shumyle Haider

MFA in Illustration & Visual Culture

This paper explores the development of Shambles & Crowley, a collection of autobiographical fiction comic strips featuring Shambles, a burnt-out boy, Crowley, a loudmouthed crow, Franz Kafka, a silent companion, Saadat Manto, a prankster, and God, an overbearing authority figure. Drawing inspiration from comic strips such as Peanuts by Charles Schulz, Calvin & Hobbes by Will Waterson, and shows such as Louie by Louis C.K, and Mr. Robot by Sam Esmail, the stories explore the inner conflicts of Shambles, which are induced by struggles with love, loneliness, depression, and faith.

Proceed With Caution: Fashion And The Case For Media Literacy, Stephanie Silva

MFA in Illustration & Visual Culture

This essay shows how one can further one’s media literacy by examining episodes of fashion as a cultural phenomenon and not an insular art practice. These episodes include Martin Margiela’s tabi boot and cultural appreciation; a Björk album cover and its potential yellowface; and the Rick Owens Spring 2014 show and the question of who gets to profit from representation in high fashion. This essay also confronts the role the Internet plays in educating the masses about fashion, both as a tool and as a distraction, and questions how a platform like Diet Prada affects fashion culture. Finally, this essay …

Personal Narratives & Their Unique Personalities, Aayesha Ejaz

MFA in Illustration & Visual Culture

This essay uncovers the motives behind memoir-writing, and explores the idea that it can serve as a gift—offering the audience some consolation by sharing one’s personal and emotional experiences. Since memoir-writing is an act of generosity, the essay also endorses the principle of crafting these narratives with love and one’s being—hands, voice, and other tangible ingredients. It focuses primarily on explicit storytelling through music, picture books, comics, et al. It also looks at some relevant terms like catharsis, misfit, vulnerability, and rigid gender roles in our world (school and society). On the whole, the essay encourages finding an outlet for …

Mothering As Feminism, Meera Patel

MFA in Illustration & Visual Culture

This critical essay proposes the concept of mothering-as-feminism, with the intention of interrogating American ideals of mothering and caregiving. Reforming the way we view mothering, as it relates to feminism, requires a re-evaluation of the American role of women and mothers—and how they are portrayed (and therefore seen and understood), valued, and supported. Focusing on the evolution of feminist theory throughout the past 70 years, as well as personal and secondary experiences, I demonstrate how political and social change occurs generationally and is dependent on the education of our children. Ultimately, I show the important role children’s literature plays …

Ambivalent Images, Beloved Objects: Building Bridges Between Picture Books And The Tangible World, Danielle Ridolfi

MFA in Illustration & Visual Culture

"Ambivalent Images, Beloved Objects" examines how pedagogical theories prioritizing objects and direct sensory experiences in early childhood can be applied to the creation of picture book illustrations. In doing so, it positions picture books as educational tools, and advocates for the importance of using them not to recreate nature, but to connect readers with the tangible world of natural and human-made objects that our digital-driven culture eclipses. It strives towards a unifying pedagogical and aesthetic philosophy that accomplishes what illustrator Eric Carle characterizes as a bridge between the tactile world of objects and the world represented in illustrations.

This exploration …

Carefree Black Girl: Trope Or Treasure?, Erin Williams

MFA in Illustration & Visual Culture

Abstract: The writing below is an experimental study on the idea of the “Carefree Black Girl,” a term coined in 2017 to define a way of life for Black women to emulate, focused on self-care and self-love. I write about its popularity and meaning, with parallels to my own life and mental health in order to define if this term is actually an attainable state of being or is more of an aspiration. I also paralleled the marriage of Meghan, Duchess of Sussex, conducted an independent poll with a small circle of Black, female contacts to learn about their knowledge …

Percepción De Docentes En Integración De Herramientas Tecnológicas Utilizando El Modelo Picrat En Una Institución De Nivel Superior, Marangely Perez Montalvo

Theses and Dissertations

Este estudio tuvo como propósito analizar la percepción de los profesores sobre el modelo de integración tecnológica PICRAT y cómo este evalúa los niveles de reemplazo, amplificación y transformación que se le realizan a las herramientas tecnológicas para lograr una interacción pasiva, interactiva y creativa con el estudiante durante el proceso de enseñanza y aprendizaje. Se utilizó un enfoque cuantitativo con un diseño transeccional no experimental con un alcance descriptivo y correlacional. La muestra estuvo compuesta por 23 profesores universitarios que imparten al menos un curso de manera remota en el nivel académico de maestría con especialidades en Ciencias de …

Identifying The Neural Correlates Of Anticipatory Postural Control: A Novel Fmri Paradigm, Jo Armour Smith, Rongwen Tain, Kelli G. Sharp, Laura M. Glynn, Linda R. Van Dillen, Korinne Henslee, Jesse V. Jacobs, Steven C. Cramer

Physical Therapy Faculty Articles and Research

Altered postural control in the trunk/hip musculature is a characteristic of multiple neurological and musculoskeletal conditions. Previously it was not possible to determine if altered cortical and subcortical sensorimotor brain activation underlies impairments in postural control. This study used a novel fMRI-compatible paradigm to identify the brain activation associated with postural control in the trunk and hip musculature. BOLD fMRI imaging was conducted as participants performed two versions of a lower limb task involving lifting the left leg to touch the foot to a target. For the supported leg raise (SLR) the leg is raised from the knee while the …

Detection Of Crypto-Ransomware Attack Using Deep Learning, Muna Jemal

Master of Science in Computer Science Theses

The number one threat to the digital world is the exponential increase in ransomware attacks. Ransomware is malware that prevents victims from accessing their resources by locking or encrypting the data until a ransom is paid. With individuals and businesses growing dependencies on technology and the Internet, researchers in the cyber security field are looking for different measures to prevent malicious attackers from having a successful campaign. A new ransomware variant is being introduced daily, thus behavior-based analysis of detecting ransomware attacks is more effective than the traditional static analysis. This paper proposes a multi-variant classification to detect ransomware I/O …

Efficient Approaches For Qubit Mapping On Nisq Computers, Sri Sesha Sailaja Lakshmi Tulasi Khandavilli

Master of Science in Computer Science Theses

—Quantum computing is gaining momentum in revolutionizing the way we approach complex problem-solving. However, the practical implementation of quantum algorithms remains a significant challenge due to the error-prone and hardware limits of near-term quantum devices. For instance, physical qubit connections are limited, which necessitates the use of quantum SWAP gates to dynamically transform the logical topology during execution. In addition, to optimize fidelity, it is essential to ensure that 1) the allocated hardware has a low error rate and 2) the number of SWAP gates injected into the circuit is minimized. To address these challenges, we propose a suite of …

Wronged Women: A Foray Into The Wronged Woman's Mind, Suzanna Poole

Master of Arts in Professional Writing Capstones

This capstone is about the wronged woman and how she is the the hated woman, the lonely woman, or the crazy woman. I have been a wronged woman and know countless women in my life that have been wronged in some sort of way; either by a lover, a friend, family, or even herself. This project was created to put a spotlight on these various women. My research covered various mental illnesses that occured after a woman was wronged and the ways these can affect women. I wrote four short screenplays about various women at different ages in their lives: …