Digital Commons Network^™

Development And Validation Of Uplc-Tqd/Ms Method For Quantification Of Six Bioactive Constituents In Thai Herbal Benjakul Formula, Benyathip Trakoolsilp, Manmas Vannabhum, Pravit Akarasereenont, Suksalin Booranasubkajorn

The Thai Journal of Pharmaceutical Sciences

Introduction: Thai herbal Benjakul formula (BKF) is a Thai traditional medicine for balancing and nourishing body elements in unhealthy persons. It is composed of five pungent plants, namely fruits of Piper retrofractum Vahl., roots of Piper sarmentosum Roxb., stems of Piper wallichii (Miq.) Hand.-Mazz., roots of Plumbago indica L., and rhizome of Zingiber officinale Roscoe. There was no efficient method for quantification of the bioactive constituents in BKF using UPLC-TQD/MS. Objective: The objective of the study was to establish a method for quantification of some constituents of BKF, namely pellitorine (PE), piperine (PI), piperlonguminine (PLM), plumbagin (PG), 6-gingerol …

Clinical Experience And Adverse Drug Events Of Favipiravir Use In Real-World Data, Thailand, Chotirat Nakaranurack, Wichai Santimaleeworagun, Gompol Suwanpimolkul, Benjabhorn Weeraphon, Watsa Charoenwaiyachet, Pattama Torvorapanit

The Thai Journal of Pharmaceutical Sciences

Favipiravir is one of the antiviral agents for coronavirus disease 2019 (COVID-19). This study described the adverse drug events (ADEs) and factors associated with aspartate transaminase (AST) or alanine transaminase (ALT) elevation in Thai COVID-19 patients who received favipiravir. A cross-sectional study was conducted at King Chulalongkorn Memorial Hospital, Thailand, among patients aged 18 years old or over with confirmed COVID-19, admitted between April and June 2021, and received favipiravir for COVID-19 treatment. Clinical pharmacists followed up ADEs after discharge from the hospital by phone. Seven hundred and fifteen COVID-19 patients were included in the study. Pharmacists could complete follow-ups …

A Comprehensive Assessment On Coumarin–Thiazole Composite As A Versatile Scaffold For The Potent Multifunctional Bioactive Agents, Swethan Babu Ravi, Muthu Kumaradoss Kathiravan

The Thai Journal of Pharmaceutical Sciences

In the discovery of new drugs, the molecular hybridization approach has emerged as a promising strategy as a multitargeted approach to prevent, treat, and address drug resistance and unmet needs. Several hybrid molecules are currently under various stages of clinical trials and could be implemented into clinical practice shortly to treat various diseases. In such purview, thiazole and coumarins play an essential role due to their diverse biological activities in medicinal chemistry. The hybridization approach of these two potential pharmacophores may lead to the discovery of newer drug candidates with a more comprehensive therapeutic application with multiple mechanisms of action. …

Drug-Induced Pseudoallergy Reaction Through Mas-Related G-Protein-Coupled Receptor X2: A Narrative Review, Zulfi Azizah, Ika Puspitasari, Muhammad Novrizal Abdi Sahid

The Thai Journal of Pharmaceutical Sciences

Pseudoallergy is a hypersensitivity condition not triggered by immunoglobulin E (IgE). These conditions can cause various health problems with symptoms identical to IgE-mediated allergic. The symptoms range from mild such as hives, to severe symptoms, such as anaphylactoid. Several drugs are known to activate mast cells directly through the mas-related G protein-coupled receptor X2 (MRGPRX2). MRGPRX2 is a receptor expressed on mast cells and responsible for their activation without being mediated by IgE. This review focuses on the types and methods of drugs that can induce pseudoallergy through MRGPRX2. The literature was collected with keywords in the form of “pseudo …

In Silico Study Of Polyphenol Compounds From Green Tea (Camellia Sinensis L.) As Inhibitors Of 3clpro Of Sars-Cov2, Junaidin Junaidin, Selvira Anandia Intan Maulidya, Krisyanti Budipramana, Faisal Ismail, Tegar Achsendo Yuniarta, Diana Sylvia

The Thai Journal of Pharmaceutical Sciences

Background: Coronavirus disease (COVID-19) outbreak prompts the world to develop novel drugs to treat the disease. Targeting the virus protein has attracted a great interest in COVID-19 drug discovery. The 3-chymotrypsin-like cysteine protease (3CLpro) of SARS-CoV-2 protein is one of the promising targets for its important role in viral replication. Various efforts have been made to find a specific therapeutic for COVID-19, including those derived from plants as anti-COVID-19. Green tea (Camellia sinensis L.) contains polyphenols which have been known for their health benefits. Objectives: This study aims to discover the activity of green tea polyphenols as 3CLpro …

Identification Of Dipeptidyl Peptidase-4 Inhibitory Compounds Of Paederia Foetida Twigs By Nuclear Magnetic Resonance Metabolomics, In Silico Models, And Liquid Chromatography–Mass Spectrometry Profiling, Dai Chuan Tan, Nur Kartinee Kassim, Intan Safinar Ismail, Siok Geok Chong

The Thai Journal of Pharmaceutical Sciences

Paederia foetida is a climber that has been traditionally used to treat various diseases, including diabetes. This study aims to investigate the dipeptidyl peptidase-4 (DPP-4) inhibitory activity of P. foetidaI/i> twig extracts and identification of the bioactive compounds by nuclear magnetic resonance (NMR) metabolomics, liquid chromatography–mass spectrometry (LC-MS), and in silico docking study. P. foetida twigs were extracted using organic solvents, namely hexane, chloroform, and methanol and submitted to DPP-4 inhibition assay. Ten milligram of each sample extract was diluted in 700 μL CDCl3 with 0.03% TMS and 1H-NMR spectra were recorded at 25°C on a JEOL FT-NMR spectrometer. The …

Anti-Inflammatory Activity Of Propolis Extract From The Stingless Bee, Tetragonula Pagdeni, In Mangosteen Orchard, Warisara Parichatikanond, Supachoke Mangmool, Savita Chewchinda, Vilasinee Hirunpanich, Boonyadist Vongsak

The Thai Journal of Pharmaceutical Sciences

In Thailand, Tetragonula pagdeni (TP) Schwarz is one of the most common and abundantly cultured stingless bee species in mangosteen orchards. The propolis extract of TP has been used as a traditional medicine to treat inflammation. TP propolis extract also exhibited antioxidant, antiproliferative, and antimicrobial properties in scientific reports. However, the anti-inflammatory effect of TP propolis extract has been limited. Thus, this study aims to evaluate the anti-inflammatory and antioxidant effects of TP propolis extract through alteration of mRNA expression of genes involved in inflammatory processes, including cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and cytokines (e.g., tumor necrosis factor-α …

2023 July - Tennessee Monthly Climate Report, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Monthly Reports

No abstract provided.

Cultural Orientations Of Northerners And Southerners, Evert Van De Vliert

Online Readings in Psychology and Culture

A growing group of psychologists recognizes that many collective mindsets and practices are functionally linked to natural habitats, which predominantly differ from north to south. Notably, cultural collectivism, power distance and aggression increase from the South Pole toward the Equator but decrease from the Equator toward the North Pole; conversely, cultural creativity, gender equality and life satisfaction decrease from the South Pole toward the Equator but increase from the Equator toward the North Pole. None of these cultural orientations varies considerably in east-west direction. Both theoretically and empirically, the most plausible explanation is that societies at higher latitudes adopt greater …

An Effective Heuristic To Reduce Total Flowtime For Randomly-Structured Flowshop Problems, Arun John Abraham

Theses

We propose a heuristic to reduce total flowtime in a six-job, four-machine permutation flowshop scheduling problem. This work contributes to the prolific research efforts reported in the permutation flowshop scheduling problem (PFSP).

The heuristic was applied to 102 randomly structured flowshop scheduling problems, with job processing times generated using an integer uniform distribution in the interval [1,100]. The results of computational experiments were deemed satisfactory after being evaluated by using the ordinal and percentile ranks of the resulting total flowtime for the six jobs.

The Role Of Psychological Safety On Employee Satisfaction And Retention In Healthcare Delivery Settings: A Systematic Literature Review, Jamey Paul

Capstone Experience: Master of Public Health

The healthcare industry typically has a high rate of employee turnover due to higher job stresses and burnout, lower job satisfaction, and insufficient organizational support and work culture. This turnover has worsened since the onset of the COVID-19 pandemic. Psychological safety, a shared belief by organizational members that the team/unit is safe for interpersonal risk-taking, can be one of the many ingredients that contribute to employee satisfaction and reduce turnover. This systematic literature review explored the role of psychological safety on job satisfaction and retention of healthcare workers in delivery settings by synthesizing the known antecedents and outcomes of psychological …

2023/2024 University Of The Pacific Graduate Catalog, University Of The Pacific

Catalogue, Bulletin, Catalog

No abstract provided.

Development And Reliability Analysis Of A Split-Administration Test Of The Math Epistemic Games Survey, Stephen Hackler, E. Elliott, M. Eichenlaub, Alison M. Sweeney

Physics & Astronomy Faculty Works

The increasing and diversifying student enrollments in introductory physics courses make reliable, valid, and usable instruments for measuring student skills and gains ever more important. In introductory physics, in addition to teaching facts about mechanics, we also seek to teach our students the skills of “thinking like a physicist,” or expertise in and intuition for physical problem solving. How and when these expert, intuitive problem-solving skills emerge during a STEM education, or what the most effective teaching methods might be, are not certain. A facile survey to measure students’ “physics-thinking” skills in a pretest and post-test format is therefore desirable …

The Remote Online Initiative: A Legislative Strategy For Rural Workforce Development In Utah, Amanda D. Ali, Paul A. Hill

Outcomes and Impact Quarterly

The Remote Online Initiative (ROI) was a legislative response to growing unemployment and limited job opportunities in rural Utah. The ROI program seeks to reduce unemployment in rural Utah communities via remote job placements. Since 2018, the ROI program has expanded to include three flagship certificate courses – Certified Remote Work Professional (CRWP), Certified Remote Work Leader (CRWL), and Certified Tech Sales Professional (CTSP). To date, evaluation results show that 411 Utah graduates found remote jobs after completing the CRWP course, 55% of participants said their department created a remote work environment and hired, on average, 19 remote employees upon …

Evaluating The “What’S Up Down South” Economic Summit: A Platform For Business Leaders To Share Ideas, Paul A. Hill, Amanda D. Ali

Outcomes and Impact Quarterly

The What’s Up Down South economic summit is southern Utah’s largest business gathering. The event provides the business community with economic insights to assist them in making informed decisions. USU Extension evaluated the 27^th annual What's Up Down South economic summit. Results showed the event was an effective platform for disseminating information and advancing knowledge on economic and business topics. Participants felt the summit provided a valuable experience to the business community. These findings support the continuation of the summit's information dissemination activities in the future.

The 2022 Intertribal Opioid Wellness Summit: Promoting The Integration Of Harm Reduction And Holistic Whole-Person Wellness Efforts, Lily Ward, Valentine Sireech, Suzi Prevedel, Cris Meier

Outcomes and Impact Quarterly

Substance Use Disorder, including Opioid Use Disorder, is a persistent problem within tribal and rural communities across Utah. In response, the Tribal and Rural Opioid Initiative Resource Center delivered an annual summit that brought together community members and local service providers impacted by substance misuse to improve awareness and use of harm reduction resources and reduce social stigma. This article describes the results of the 2022 Intertribal Opioid Wellness Summit.

Treatment Of Chronic Migraine With Botox (Onabotulinumtoxina): Development, Insights, And Impact, Catherine C. Turkel, Sheena Aurora, Hans-Christoph Diener, David W. Dodick, Richard B. Lipton, Stephen D. Silberstein, Mitchell F. Brin

Department of Jefferson Headache Center Papers and Presentations

Chronic migraine (CM) is a neurological disease characterized by frequent migraine attacks that prevent affected individuals from performing daily activities of living, significantly diminish quality of life, and increase familial burden. Before onabotulinumtoxinA was approved for CM, there were few treatment options for these seriously disabled patients and none had regulatory approval. The terminology and recognition of CM evolved in parallel with the onabotulinumtoxinA clinical development program. Because there were no globally accepted classification criteria for CM when onabotulinumtoxinA was in development, the patient populations for the trials conducted by Allergan were determined by the Allergan migraine team in collaboration …

Review Of Heaven & Earth Grocery, Michael F. Russo

Faculty Publications

No abstract provided.

A Structural And Provider Behavior Change Approach To Enhancing Respectful, Integrative, Responsive Care For Hospitalized Young Children (0–24 Months) In Kenya, Breakthrough Research

Sexual and Reproductive Health, Rights, and Choices

This brief describes a co-creation process and a resulting provider behavior change intervention approach that can be adapted to similar low- and middle-income hospital contexts. It offers policy and program managers details around each intervention component, linking to an accompanying provider orientation PowerPoint and other training materials/job aids. Finally, it recommends a few lessons to guide those interested in engaging in a similar co-creation and implementation approach.

Findings From A Mixed Methods Evaluation Of An Integrated Social And Behavior Change Approach To Improve Health Outcomes In Niger, Breakthrough Research

Sexual and Reproductive Health, Rights, and Choices

This brief summarizes findings from a mixed methods evaluation of an integrated social and behavior change (SBC) approach implemented in the Maradi and Zinder regions of Niger. It is intended to inform the Resilience in the Sahel Enhanced (RISE) II program implemented by the United States Agency for International Development (USAID) funded Resilience Food Security Activities (RFSA) to further improve reproductive, maternal, and child health outcomes. This brief provides an overview of the integrated SBC approach and evaluation methods and then guided by the program theory of change, describes the mechanisms through which the intervention contributed to change in health …

A Tribal Chief And A Colonial Legislation: The Excluded Areas Act Of 1846, Amrita Tulika

Socio-Legal Review

This article explores the nature of colonial sovereignty from a Hobbesian lens of ‘state necessity’ by taking the example of the Excluded Areas Act of 1846. This Act was a special law that placed the Bhil tribes of the Khandesh and Ahmadnagar districts (in present-day Maharashtra) outside the purview of the general laws in the Bombay Presidency. By drawing from archival sources, including records of the East India Company and legislative proceedings, the paper contrasts pre-colonial tribal autonomy with authoritarian and paternalistic colonial rule by a British Agent under the Act. First, the paper locates its argument on colonial rule …

Who's Publishing What: The Jon Boat Years, Erma Bombeck Writers' Workshop

Erma Bombeck Writers' Workshop Blog

Jim Mize has published his fifth book, The Jon Boat Years: And Other Stories Afield With Fine Friends, Fair Dogs, a Shotgun, and a Fly Rod.

Humor Writer Of The Month: Joan Arent, Erma Bombeck Writers' Workshop

Erma Bombeck Writers' Workshop Blog

Our Humor Writer of the Month for July is Joan Arent, a presenter, illustrator and author who motivates others to succeed through lighthearted living and play.

Leccionario B 2023-2024, Lcms

Liturgias

Leccionario B 2023-2024

Factors Affecting Treatment Adherence Among Leprosy Patients: Perceptions Of Healthcare Providers, Veincent Christian F. Pepito, Arianna Maever Loreche, Rae Erica D. Samontina, Sarah Jane A. Abdon, David Norman L. Fuentes, Ofelia P. Saniel

Ateneo School of Medicine and Public Health Publications

Background

Treatment adherence is a vital aspect in the management of chronic diseases like leprosy; however, most studies on treatment adherence focus on patients. This study aims to examine the perceptions of healthcare providers on factors that can promote or prevent patients from adhering to treatment.

Methods

We conducted three focus group discussions (FGDs) with healthcare providers who have at least one year experience in managing leprosy in three large leprosy case-holding hospitals in Metro Manila, Philippines. We audio-recorded, transcribed, translated the FGD proceedings, and analyzed the transcripts thematically to identify patient-intrinsic and patient-extrinsic enablers and barriers to treatment adherence …

The Viral Picture Of Well-Being: Biggest Concerns, Losses, And Unintended Gifts Of Covid-19 In The Philippines, Ma Teresa Tuason, Kelly Perniciaro, Richel Lamadrid, Jego Mallillin, C. Dominik Güss

Ateneo School of Medicine and Public Health Publications

The COVID-19 pandemic revealed more than anticipated about global human functioning and resiliency. This Philippines-based study replicated a recent U.S. COVID analysis on psychological well-being (PWB). Factors examined herein were grouped into categories for analysis: 1) predictors of PWB, 2) areas of greatest stress or worry (biggest concerns), 3) perceived or real losses across SES, and 4) identified “unintended gifts” across PWB. Participants (n = 1345) were volunteers who responded to an online survey from August to September 2021, peak of the Delta variant. Three general groups of predictors (biological, psychological, and socio-economic) contributed to PWB. A regression model containing …

Summer 2023, Echoes Staff

Rose Echoes

No abstract provided.

Covid Vaccine Policy 2023 Update

Human Resources Policies

For the safety of its employees and students, has adopted a policy regarding vaccination for COVID-19. From June 2022 through May 11, 2023, UHSP had a strict “fully vaccinated” requirement for all faculty, staff and students who did not have a valid medical or religious exemption. With the end of the COVID-19 public health emergency declaration, UHSP has shifted its stance to highly recommending the COVID-19 vaccine. Certain employees and students, such as faculty with clinical responsibilities and students rotating through sites requiring vaccination, such as in the Pharm.D. program, are still required to be fully vaccinated.

Studying The Topological Sector Of Quantum Gravity With Branched Covering Spaces, Christopher L. Duston

Physics Faculty Publications

Spatial topology change is generally expected to be prohibited classically, being present only at the quantum scale. However, including topology change into many of the current approaches to quantum gravity (such as Loop Quantum Gravity (LQG) and Causal Dynamical Triangulations (CDT)) has proven difficult for technical reasons. In this work we explore this sector numerically using branched covering spaces (in LQG this corresponds to the utilization of Topspin Networks). To this end, we have implemented a group-theoretic algorithm coming from knot theory to measure the topology of arbitrary spatial sections in a systematic way, and have constructed a statistical ensemble …

Policies, Practices And The Future Of Technical And Vocational Education And Training For Communities In The Margins, Matthew A. Witenstein, Radhika Iyengar

Educational Leadership Faculty Publications

Prior to embarking on this special issue, we had begun working on our own technical and vocational education and training (TVET) research project studying women’s upskilling in India. The Indian government demarcated women’s upskilling as an important initiative in their 12th five-year plan (an economic plan strategizing development and growth), which particularly remarked about the criticality of improving access while also notating the challenges and equity points that need to be worked on including economic empowerment and engagement in governance (Planning Commission, 2013). We then realized there was a need for studies on the ground to gauge whether this endeavor/initiative …