Digital Commons Network^™

Transitioning Statistical Iterative Dual-Energy Ct Reconstruction To The Clinic: Artifact Reduction And Machine Learning-Based Acceleration, Tao Ge

McKelvey School of Engineering Graduate Student Theses & Dissertations

Over the past few decades, dual-energy X-ray computed tomography (DECT) imaging has undergone significant advancements, mainly attributed to its remarkable ability to differentiate between different materials. In contrast to conventional X-ray computed tomography (CT), DECT employs two measurements acquired at distinct spectra, enabling the generation of highly informative and precise images, including material decomposition maps, virtual non-contrast images, and stopping-power maps for proton treatment plans. Image-domain decomposition (IDD) is a widely utilized technique in DECT imaging, assuming that low- and high-energy images can be represented as linear combinations of material decomposition maps on an element-wise basis. On the other hand, …

Combatting Teacher Attrition Through The Use Of Mentorship Programs, Logan Vallie

Masters Projects

Research has revealed important information regarding the recurring problem of teacher attrition throughout the field of education and solutions to combat the ongoing problem. This project explores the reasons that teachers are leaving the field early before retirement and subsequently, the development of mentorship programs in an effort to eradicate the problem. It has been concluded that mentorships are beneficial to the growth and retention of quality teachers, but current programs are lacking in some areas, leading to ineffective implementation of these programs. The proposed elements to the correct implementation of a quality program include best practices being instituted, specifically …

The Effect Of Third Dose Of Pfizer/Biontech And Moderna Covid-19 Mrna Vaccines On Igg Antibody Titers, Thao A. Khuc, Gregery Pequeno, Monica M. Betancourt-Garcia, Adrienne M. Casciato, Marissa Gomez-Martinez, Carlos D. Arroyo, Bill D. Pope Iii, Shravan Narmala, Sohail Rao

School of Medicine Publications

With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, the Centers for Disease Control and Prevention (CDC) authorized the third dose of the Pfizer-BioNTech (BNT162b2) vaccine with the rationale for prolonged elevation of anti-SARS-CoV-2 antibody titers and protection against the SARS-CoV-2 virus.

To better understand how administration of the third dose of the Pfizer/BioNTech coronavirus disease 2019 (COVID-19) vaccine affects the incidence and severity of SARS-CoV-2 infections, we administered the third dose of the Pfizer-BioNTech (BNT162b2) to 189 participants. Blood samples were collected from participants during each of their scheduled visits (baseline, week two, week 12, and …

A Global Study For Acute Myeloid Leukemia With Rarg Rearrangement, Hong-Hu Zhu, John S Welch, Et Al.

2020-Current year OA Pubs

Acute myeloid leukemia (AML) with retinoic acid receptor γ (RARG) rearrangement has clinical, morphologic, and immunophenotypic features similar to classic acute promyelocytic leukemia. However, AML with RARG rearrangement is insensitive to alltrans retinoic acid (ATRA) and arsenic trioxide (ATO) and carries a poor prognosis. We initiated a global cooperative study to define the clinicopathological features, genomic and transcriptomic landscape, and outcomes of AML with RARG rearrangements collected from 29 study groups/institutions worldwide. Thirty-four patients with AML with RARG rearrangements were identified. Bleeding or ecchymosis was present in 18 (54.5%) patients. Morphology diagnosed as M3 and M3v accounted for 73.5% and …

Temperature-Pressure Phase Diagram Of Confined Monolayer Water/Ice At First-Principles Accuracy With A Machine-Learning Force Field, Bo Lin, Jian Jiang, Xiao Cheng Zeng, Lei Li

Department of Chemistry: Faculty Publications

Understanding the phase behaviour of nanoconfined water films is of fundamental importance in broad fields of science and engineering. However, the phase behaviour of the thinnest water film – monolayer water – is still incompletely known. Here, we developed a machine-learning force field (MLFF) at first-principles accuracy to determine the phase diagram of monolayer water/ice in nanoconfinement with hydrophobic walls. We observed the spontaneous formation of two previously unreported high-density ices, namely, zigzag quasi-bilayer ice (ZZ-qBI) and branched-zigzag quasi-bilayer ice (bZZ-qBI). Unlike conventional bilayer ices, few inter-layer hydrogen bonds were observed in both quasi-bilayer ices. Notably, the bZZ-qBI entails a …

Pull-Push Method: A New Approach To Edge-Isoperimetric Problems, Sergei L. Bezrukov, Nikola Kuzmanovski, Jounglag Lim

Department of Mathematics: Faculty Publications

We prove a generalization of the Ahlswede-Cai local-global principle. A new technique to handle edge-isoperimetric problems is introduced which we call the pull-push method. Our main result includes all previously published results in this area as special cases with the only exception of the edge-isoperimetric problem for grids. With this we partially answer a question of Harper on local-global principles. We also describe a strategy for further generalization of our results so that the case of grids would be covered, which would completely settle Harper’s question.

Ecg Recordings As Predictors Of Very Early Autism Likelihood: A Machine Learning Approach, Deepa Tilwani, Jessica Bradshaw, Amit Sheth, Christian O'Reilly

Publications

In recent years, there has been a rise in the prevalence of autism spectrum disorder (ASD). The diagnosis of ASD requires behavioral observation and standardized testing completed by highly trained experts. Early intervention for ASD can begin as early as 1–2 years of age, but ASD diagnoses are not typically made until ages 2–5 years, thus delaying the start of intervention. There is an urgent need for non-invasive biomarkers to detect ASD in infancy. While previous research using physiological recordings has focused on brain-based biomarkers of ASD, this study investigated the potential of electrocardiogram (ECG) recordings as an ASD biomarker …

Multiple Ways To Implement And Infer Sentience, Nicolas Rouleau, Michael Levin

Animal Sentience

Segundo-Ortin & Calvo’s (S&C’s) thorough review of “plant neurobiology” presents evidence supporting the possibility of plant sentience. They make a compelling case that plants anticipate, assess risk, cooperate, mimic, and pursue goals, as do their animal counterparts. S&C point out that there is a double standard: behavioural patterns associated with subjective experiences in humans are considered valid for inferring cognition in non-human animals but not in diverse other systems including plants. We argue that cognitive functions, including sentience, can potentially be achieved by very different systems and their disparate substrates. We offer some context from the basal cognition literature and …

Industry 4.0 And Circular Economy: Opportunities Of Mena Countries On The Path To The Sustainable Development, Suzanna Elmassah

All Works

No abstract provided.

User Feedback On The Elements Influencing The Efficiency Of Resources, Services, And Facilities Offered By Higher Education Institutions' Libraries, Ramakrishna Kona

Library Philosophy and Practice (e-journal)

The study examined User feedback on the elements influencing the efficiency of resources, services, and facilities offered by higher education institutions' libraries. This study distributed 1164 questionnaires and received responses of 1030, the overall response percentage is 88. The survey found that the response rate varied between 71 and 100 among teachers, 68 and 91 percent among research scholars, and 84 and 95 percent among postgraduate students. The study found that the majority of students visit the library once a week. The study reveals that the majority of the users (nearly 96%) responded positively and expressed their view that the …

Optimizing The Management Of The Records Center In The Archive Rescue Program In The Eka Karya Bali Botanical Garden Scientific Conservation Area, Dhatu Kamajati, Ken Fitria Indrawardani Kfi, Suyatmi -. -, I Luh Ayu Sulistyawati, Dwi Ridho Aulianto

Library Philosophy and Practice (e-journal)

The Eka Karya Botanical Garden Scientific Conservation Area is one of the Archival Units II which is included in the Archive Area Service of the National Research and Innovation Agency with the duties and responsibilities of managing inactive archives that have a retention of under 10 years. In archive rescue activities as a result of the merger of several institutions within BRIN, the existence of the Records Center really needs to be optimized as one of the strategic steps in the stages of archive rescue activities, especially those that have status as inactive archives. This paper aims to describe how …

Measurements Of Scintillation Light Quenching For Protons In Rare-Earth Inorganic Scintillators, Tatiana Nathaly Espinoza

Nuclear Engineering ETDs

Scintillator detectors have become a leading choice of radiation detectors for a variety of applications, including space science. Due to their intrinsic characteristics, rare-earth inorganic scintillators provide the capability to detect both gamma and charged particles in a small detector. The response of these detectors is typically characterized using isotropic gamma sources. However, the light output produced in the scintillator from an incident gamma of a particular energy differs from the light output produced from an incident charged particle of the same energy; a phenomenon known as quenching. Using two types of rare-earth inorganic scintillators, Y2SiO5(YSO:Ce), and Gd₃Al₂Ga₃O₁₂(GAGG:Ce), we measured …

Uab Hht Clinic Named Center Of Excellence, Hannah Echols

Browse All News

No abstract provided.

Noise Analysis Of The Indian Pulsar Timing Array Data Release I, Aman Srivastava, Shantanu Desai, Neel Kolhe, Mayuresh Surnis, Bhal Chandra Joshi, Abhimanyu Susobhanan, Aurélien Chalumeau, Shinnosuke Hisano, Nobleson K, Raghav Girgaonkar

Physics & Astronomy Faculty Publications

The Indian Pulsar Timing Array (InPTA) collaboration has recently made its first official data release (DR1) for a sample of 14 pulsars using 3.5 years of uGMRT observations. We present the results of single-pulsar noise analysis for each of these 14 pulsars using the InPTA DR1. For this purpose, we consider white noise, achromatic red noise, dispersion measure (DM) variations, and scattering variations in our analysis. We apply Bayesian model selection to obtain the preferred noise models among these for each pulsar. For PSR J1600−3053, we find no evidence of DM and scattering variations, while for PSR J1909−3744, we find …

Big Interview Replaces Interviewstream As Uab's Interview Practice Platform, Reporter Staff

Browse All News

No abstract provided.

Exploration Of Efficient Dewatering Methods In Stimulus-Responsive Hydrogels And Their Potential For Desalination, Weiliang Sun

LSU Doctoral Dissertations

Addressing global freshwater scarcity is a pressing challenge, and desalination has emerged as a viable solution to generate high-quality water without compromising natural freshwater ecosystems. In comparison to conventional desalination methods such as thermal distillation and membrane-based processes, hydrogels offer distinct advantages including strong water absorption, water retention, well-defined pore structures, customizable functional groups, and responsive properties to external stimuli. These unique characteristics position hydrogels as promising candidates for water treatment applications. Hydrogel-based desalination involves the utilization of hydrogels to absorb water from saltwater, and then discharge low-concentration solutions to obtain reclaimed water. The fundamental principle underlying the desalination ability …

The Case For Succession Planning In Higher Education: A Study Of Knowledge Transfer Within Louisiana State University, Leila Shaik Villien

LSU Doctoral Dissertations

The primary purpose of this study was to explore the challenges, benefits, and perceptions of succession planning among currently employed administrators at research universities in the southern portion of the United States at the level of assistant department head or higher and the accessible population was defined as currently employed administrators at Louisiana State University at the level of assistant department head or higher. Deans, Associate Deans, Department Heads, Assistant Department Heads, and Department Chairs were invited to participate in an online survey designed by the researcher to assess the attitude toward succession planning and training, along with a variety …

Women's Interracial Friendships: Cultivating Coalitional Possibilities Across Difference Through Dialogue, Akie Fukushige Wenk

LSU Doctoral Dissertations

In my dissertation, I thread through the macro-structure as well as micro-operations of hegemonic ideologies, namely white-supremacist capitalist cis-hetero patriarchy (hooks, 1995, Valdes, 1996), that has historically plagued the United States, eventually gaining a global reach over time. I center interracial friendship between Black and White cis-women, where I locate coalitional possibilities that begin at the grassroots level. I situate this interracial relationship within the socio-ecological system where the personal meets the social (including racialized backgrounds). I use a series of analogies to equate these ideologies as toxins in the air, water, and soil. Soil is where we can work …

First-Principles Simulations Of Attosecond Transient X-Ray Absorption, Min Chen

LSU Doctoral Dissertations

The first part of this dissertation presents calculations of the extinction spec- tra of gold-silver/silver-gold core-shell nanospheres. The goal of this projectsis to get a deeper understanding of surface plasmonic resonance in metal nanospheres with core-shell geometry. Here, we used the finite-difference time-domain (FDTD) method and total-field/scattered-field (TFSF) framework to compute the extinction spectra of nanoparticles to determine the geometry of gold-silver/silver-gold core-shell nanoparticles. This supported experimental work on monitoring the growth dynamics of colloidal gold- silver/silver-gold core-shell nanoparticles using in situ second harmonic generation (SHG) and extinction spectroscopy.

The second and main project involved simulating attosecond transient spectra for …

Morphological And Molecular Characterization Of The Olfactory System In The Formosan Subterranean Termite, Paula Castillo

LSU Doctoral Dissertations

The Formosan subterranean termite, Coptotermes formosanus, is a eusocial insect species. Its members live in colonies consisting of reproductive (queen and king) and non-reproductive individuals (workers and soldiers). Olfaction is an essential sense for the social life of many insects. However, in termites, little is known about how olfactory cues are perceived in the peripheral sensory system (antennae) and processed in the central nervous system (brain) to elicit different behavioral responses across castes. In this study, we investigated the olfactory system in all castes (soldiers, workers, and reproductive alates), from the antennal and brain morphology to the antennal gene …

Computational Design Of Electro-Organocatalysts And Transition Metal Sulfides For The Electrochemical Reduction Of Co2, Foroogh Khezeli

LSU Doctoral Dissertations

Abstract

Electrochemical CO₂ reduction (ECO₂RR) has emerged as a promising approach for generating carbon-neutral liquid fuels by utilizing excess renewable electricity to convert CO₂. This thesis aims to employ atomistic simulations by using Density Functional Theory (DFT) to investigate the mechanistic details of how transition metal sulfides and electro-organocatalysts can enhance the activity and selectivity towards desired products, including those containing C-H bonds and molecules with C-C bonds. For this project, three different electrocatalysts were designed computationally.

Firstly, MoS₂ was chosen as a transition metal sulfide catalyst with the objective of understanding the kinetics …

Implicit Bias In School-Based Suicide Risk Assessment, Jessie Munson

LSU Doctoral Dissertations

Suicide remains a leading cause of death for youth, and the prevalence of suicidal behaviors continues to increase while demographic trends shift. Despite the considerable scope and impact of this global public health issue and robust evidence that cultural minority and gender-diverse youth are at particular risk, there is a significant dearth in the literature with respect to nonrandom variance or possible systematic error in suicide risk assessment practices. Moreover, studies related to school-based risk assessment are scarce despite the ethical and legal imperative to identify and serve at-risk youth as well as the unique ecological position of schools to …

Predicted Structure And Functional Roles Of Alphaherpesvirus Tegument Protein Ul37 In Virion Morphogenesis And Innate Immunity, Therese Marie Collantes

LSU Doctoral Dissertations

Several members of the Family Herpesviridae are clinically significant pathogens, affecting humans and a wide range of animals. Alphaherpesviruses infect epithelial cells at the primary site of infection and subsequently invade adjacent sensory neurons. Infectious bovine rhinotracheitis (IBR) is an economically important disease caused by bovine herpesvirus 1 (BoHV-1), which belongs to the subfamily Alphaherpesvirinae, genus Varicellovirus. To date, vaccination is the only preventive measure against IBR. Understanding determinants of herpesvirus replication and innate immune regulation is important to help further develop vaccines that are efficacious and incapable of establishing latency in the host nervous system. The alphaherpesvirus …

Integrating Behavioral Research Findings With A Liberal Arts Paradigm, Jonathan Peterson

LSU Master's Theses

This paper explores the role of behavioral research in understanding the complexity and relevance of creativity. A brief history of the liberal arts and its current application is followed by a discussion of the importance of variability in generating novel and diverse responses, challenging the notion that creativity is solely a product of innate talent. The effects of reinforcement on variability, and how it relates to a complex relationship between reinforcement and the probability of variable responding leads to a discussion of how the combination of previously trained behaviors can lead to creative problem-solving, emphasizing the role of combinatory behavior …

Proteoglycan 4 (Prg4)/Lubricin And The Extracellular Matrix In Gout, Khaled A. Elsaid, Gregory D. Jay, Ru Liu-Bryan, Robert Terkeltaub

Pharmacy Faculty Articles and Research

Proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes, released into synovial fluid, and adsorbed on cartilage and synovial surfaces. PRG4′s roles include cartilage boundary lubrication, synovial homeostasis, immunomodulation, and suppression of inflammation. Gouty arthritis is mediated by monosodium urate (MSU) crystal phagocytosis by synovial macrophages, with NLRP3 inflammasome activation and IL-1β release. The phagocytic receptor CD44 mediates MSU crystal uptake by macrophages. By binding CD44, PRG4 limits MSU crystal uptake and downstream inflammation. PRG4/CD44 signaling is transduced by protein phosphatase 2A, which inhibits NF-κB, decreases xanthine oxidoreductase (XOR), urate production, and ROS-mediated IL-1β …

An Extension Of The Complex–Real (C–R) Calculus To The Bicomplex Setting, With Applications, Daniel Alpay, Kamal Diki, Mihaela Vajiac

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this paper, we extend notions of complex ℂ−ℝ-calculus to the bicomplex setting and compare the bicomplex polyanalytic function theory to the classical complex case. Applications of this theory include two bicomplex least mean square algorithms, which extend classical real and complex least mean square algorithms.

A Global Study For Acute Myeloid Leukemia With Rarg Rearrangement, Hong-Hu Zhu, Ya-Zhen Qin, Zhang-Lin Zhang, Yong-Jing Liu, Li-Jun Wen, Cheng Zhang, Hong Luo, Hong-Jian Yuan, Hong-Sheng Zhou, Hong-Xing Liu, Reng Xu, Ji Li, Jian-Hu Li, Jian-Ping Hao, Jie Jin, Liang Yu, Jing-Ying Zhang, Li-Ping Liu, Le-Ping Zhang, Rui-Bin Huang, Shu-Hong Shen, Su-Jun Gao, Wei Wang, Xiao-Jing Yan, Xin-You Zhang, Xin Du, Xiao-Xia Chu, Yan-Fang Yu, Yi Wang, Ying-Chang Mi, Ying Lu, Zhen Cai, Zhan Su, David Christopher Taussig, Suzanne Macmahon, Edward D Ball, Huan-You Wang, John S Welch, C Cameron Yin, Gautam Borthakur, Miguel A Sanz, Hagop M Kantarjian, Jin-Yan Huang, Jiong Hu, Su-Ning Chen

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) with retinoic acid receptor γ (RARG) rearrangement has clinical, morphologic, and immunophenotypic features similar to classic acute promyelocytic leukemia. However, AML with RARG rearrangement is insensitive to alltrans retinoic acid (ATRA) and arsenic trioxide (ATO) and carries a poor prognosis. We initiated a global cooperative study to define the clinicopathological features, genomic and transcriptomic landscape, and outcomes of AML with RARG rearrangements collected from 29 study groups/institutions worldwide. Thirty-four patients with AML with RARG rearrangements were identified. Bleeding or ecchymosis was present in 18 (54.5%) patients. Morphology diagnosed as M3 and M3v accounted for 73.5% and …

Emt Activates Exocytotic Rabs To Coordinate Invasion And Immunosuppression In Lung Cancer, Guan-Yu Xiao, Xiaochao Tan, Bertha L Rodriguez, Don L Gibbons, Shike Wang, Xin Liu, Mayra E Vasquez, Hai T Tran, Jun Xu, William K Russell, Cara Haymaker, Younghee Lee, Jianjun Zhang, Luisa Solis, Ignacio I Wistuba, Jonathan M Kurie

Faculty, Staff and Student Publications

Epithelial-to-mesenchymal transition (EMT) underlies immunosuppression, drug resistance, and metastasis in epithelial malignancies. However, the way in which EMT orchestrates disparate biological processes remains unclear. Here, we identify an EMT-activated vesicular trafficking network that coordinates promigratory focal adhesion dynamics with an immunosuppressive secretory program in lung adenocarcinoma (LUAD). The EMT-activating transcription factor ZEB1 drives exocytotic vesicular trafficking by relieving Rab6A, Rab8A, and guanine nucleotide exchange factors from miR-148a-dependent silencing, thereby facilitating MMP14-dependent focal adhesion turnover in LUAD cells and autotaxin-mediated CD8

When A Calorie Is Not Just A Calorie: Diet Quality And Timing As Mediators Of Metabolism And Healthy Aging, Maria M Mihaylova, Amandine Chaix, Mirela Delibegovic, Jon J Ramsey, Joseph Bass, Rajat Singh, William W Ja, Michele Shirasu-Hiza, Mary N Latimer, Julie A Mattison, Anna E Thalacker-Mercer, Vishwa Deep Dixit, Satchidananda Panda, Dudley W Lamming

Faculty, Staff and Student Publications

An epidemic of obesity has affected large portions of the world, increasing the risk of developing many different age-associated diseases, including cancer, cardiovascular disease, and diabetes. In contrast with the prevailing notion that "a calorie is just a calorie," there are clear differences, within and between individuals, in the metabolic response to different macronutrient sources. Recent findings challenge this oversimplification; calories from different macronutrient sources or consumed at different times of day have metabolic effects beyond their value as fuel. Here, we summarize discussions conducted at a recent NIH workshop that brought together experts in calorie restriction, macronutrient composition, and …

High Throughput Single Cell Long-Read Sequencing Analyses Of Same-Cell Genotypes And Phenotypes In Human Tumors, Cheng-Kai Shiau, Lina Lu, Rachel Kieser, Kazutaka Fukumura, Timothy Pan, Jie Yang, Gahyun Lee, Yuanqing Yan, Jason T Huse, Ruli Gao

Faculty, Staff and Student Publications

Single-cell nanopore sequencing of full-length mRNAs transforms single-cell multi-omics studies. However, challenges include high sequencing errors and dependence on short-reads and/or barcode whitelists. To address these, we develop scNanoGPS to calculate same-cell genotypes (mutations) and phenotypes (gene/isoform expressions) without short-read nor whitelist guidance. We apply scNanoGPS onto 23,587 long-read transcriptomes from 4 tumors and 2 cell-lines. Standalone, scNanoGPS deconvolutes error-prone long-reads into single-cells and single-molecules, and simultaneously accesses both phenotypes and genotypes of individual cells. Our analyses reveal that tumor and stroma/immune cells express distinct combination of isoforms (DCIs). In a kidney tumor, we identify 924 DCI genes involved in …