Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 530071 - 530100 of 5207311

Full-Text Articles in Entire DC Network

Brentuximab Vedotin After Autologous Transplantation In Pediatric Patients With Relapsed/Refractory Hodgkin Lymphoma, Christopher J Forlenza, Jaclyn Rosenzweig, Audrey Mauguen, Ilia Buhtoiarov, Branko Cuglievan, Rebecca J Deyell, Anna K Franklin, Jennifer Krajewski, Kasey J Leger, Lianna J Marks, Robin E Norris, Martha Pacheco, Faye Willen, Adam Paul Yan, Paul D Harker-Murray, Lisa Giulino-Roth Jul 2023

Brentuximab Vedotin After Autologous Transplantation In Pediatric Patients With Relapsed/Refractory Hodgkin Lymphoma, Christopher J Forlenza, Jaclyn Rosenzweig, Audrey Mauguen, Ilia Buhtoiarov, Branko Cuglievan, Rebecca J Deyell, Anna K Franklin, Jennifer Krajewski, Kasey J Leger, Lianna J Marks, Robin E Norris, Martha Pacheco, Faye Willen, Adam Paul Yan, Paul D Harker-Murray, Lisa Giulino-Roth

Faculty, Staff and Student Publications

Outcomes for children and adolescents with relapsed and refractory Hodgkin lymphoma (HL) are poor, with ∼50% of patients experiencing a subsequent relapse. The anti-CD30 antibody-drug conjugate brentuximab vedotin improved progression-free survival (PFS) when used as consolidation after autologous stem cell transplantation (ASCT) in adults with high-risk relapsed/refractory HL. Data on brentuximab vedotin as consolidative therapy after ASCT in pediatric patients with HL are extremely limited, with data of only 11 patients reported in the literature. We performed a retrospective analysis of 67 pediatric patients who received brentuximab vedotin as consolidation therapy after ASCT for the treatment of relapsed/refractory HL to …

Go to article

The Potential Of Probiotics As Ingestible Adjuvants And Immune Modulators For Antiviral Immunity And Management Of Sars-Cov-2 Infection And Covid-19, Sophie Tomkinson, Cloe Triscott, Emily Schenk, Andrew Foey Jul 2023

The Potential Of Probiotics As Ingestible Adjuvants And Immune Modulators For Antiviral Immunity And Management Of Sars-Cov-2 Infection And Covid-19, Sophie Tomkinson, Cloe Triscott, Emily Schenk, Andrew Foey

School of Biomedical Sciences

Probiotic bacteria are able to modulate general antiviral responsiveness, including barrier functionality and innate and adaptive immune responses. The COVID-19 pandemic, resulting from SARS-CoV-2 infection, has created a need to control and treat this viral infection and its ensuing immunopathology with a variety of approaches; one such approach may involve the administration of probiotic bacteria. As with most viral infections, its pathological responses are not fully driven by the virus, but are significantly contributed to by the host’s immune response to viral infection. The potential adoption of probiotics in the treatment of COVID-19 will have to appreciate the fine line …

Go to article

Phytoplankton Responses To Dust Addition In The Femn Co-Limited Eastern Pacific Sub-Antarctic Differ By Source Region, Neil J. Wyatt, Antony Birchill, Simon Ussher, Angela Milne, Heather A. Bouman, Elizabeth Shoenfelt Troein, Katsiaryna Pabortsava, Alan Wright, Oliver Flanagan, Thomas S. Bibby, Adrian Martin, Cm Moore Jul 2023

Phytoplankton Responses To Dust Addition In The Femn Co-Limited Eastern Pacific Sub-Antarctic Differ By Source Region, Neil J. Wyatt, Antony Birchill, Simon Ussher, Angela Milne, Heather A. Bouman, Elizabeth Shoenfelt Troein, Katsiaryna Pabortsava, Alan Wright, Oliver Flanagan, Thomas S. Bibby, Adrian Martin, Cm Moore

School of Geography, Earth and Environmental Sciences

The seasonal availability of light and micronutrients strongly regulates productivity in the Southern Ocean, restricting biological utilization of macronutrients and CO2 drawdown. Mineral dust flux is a key conduit for micronutrients to the Southern Ocean and a critical mediator of multimillennial-scale atmospheric CO2 oscillations. While the role of dust-borne iron (Fe) in Southern Ocean biogeochemistry has been examined in detail, manganese (Mn) availability is also emerging as a potential driver of past, present, and future Southern Ocean biogeochemistry. Here, we present results from fifteen bioassay experiments along a north–south transect in the undersampled eastern Pacific sub-Antarctic zone. In addition to …

Go to article

Author Correction: Drugnomeai Is An Ensemble Machine-Learning Framework For Predicting Druggability Of Candidate Drug Targets, Lawrence Middleton, Ryan S Dhindsa, Pamela Hill, Ola Engkvist, Andrew R Harper, Slavé Petrovski, Dimitrios Vitsios Jul 2023

Author Correction: Drugnomeai Is An Ensemble Machine-Learning Framework For Predicting Druggability Of Candidate Drug Targets, Lawrence Middleton, Ryan S Dhindsa, Pamela Hill, Ola Engkvist, Andrew R Harper, Slavé Petrovski, Dimitrios Vitsios

Faculty, Staff and Students Publications

No abstract provided.

Go to article

Randomized, Double-Blinded, Placebo-Controlled Trial Of Allogeneic Cord Blood T-Regulatory Cells For Treatment Of Covid-19 Ards, Mi-Ae Lyu, Jason R Mock, Kevin W Gibbs, Darryl Abrams, Meixian Huang, Ke Zeng, James P Herlihy, Sergio T Castillo, Roland Bassett, Tara Sadeghi, Simrit Parmar, Christopher R Flowers, Siddhartha Mukherjee, David Schoenfeld, Peter F Thall, Arthur S Slutsky Jul 2023

Randomized, Double-Blinded, Placebo-Controlled Trial Of Allogeneic Cord Blood T-Regulatory Cells For Treatment Of Covid-19 Ards, Mi-Ae Lyu, Jason R Mock, Kevin W Gibbs, Darryl Abrams, Meixian Huang, Ke Zeng, James P Herlihy, Sergio T Castillo, Roland Bassett, Tara Sadeghi, Simrit Parmar, Christopher R Flowers, Siddhartha Mukherjee, David Schoenfeld, Peter F Thall, Arthur S Slutsky

Faculty, Staff and Students Publications

No abstract provided.

Go to article

Building Capacity Of Community Nurses To Strengthen The Management Of Uncomplicated Hypertension In Persons Living With Hiv In Low- And Middle-Income Countries, Dike Ojji, Daphne Lew, Et Al. Jul 2023

Building Capacity Of Community Nurses To Strengthen The Management Of Uncomplicated Hypertension In Persons Living With Hiv In Low- And Middle-Income Countries, Dike Ojji, Daphne Lew, Et Al.

2020-Current year OA Pubs

OBJECTIVES: Poor training of non-physician healthcare workers (especially community nurses) could hinder the successful integration of cardiovascular disease (CVD) management into HIV chronic care in primary healthcare facilities in low- and middle-income countries. To address this limitation, we included a holistic training programme with a robust module for both practice facilitators and community nurses as part of the formative stages of the managing hypertension among people living with HIV: an integrated model (MAP-IT), which is a study that is evaluating the effectiveness of practice facilitation on the integration of a task-strengthening strategy for hypertension control (TASSH) into primary healthcare centres …

Go to article

A Multicenter Analysis Of The Outcomes With Venetoclax In Patients With Relapsed Mantle Cell Lymphoma, Yazeed Sawalha, Scott Goldsmith, Brad S Kahl, Et Al. Jul 2023

A Multicenter Analysis Of The Outcomes With Venetoclax In Patients With Relapsed Mantle Cell Lymphoma, Yazeed Sawalha, Scott Goldsmith, Brad S Kahl, Et Al.

2020-Current year OA Pubs

To report the activity of venetoclax in patients with relapsed mantle cell lymphoma (MCL), we identified 81 patients treated with venetoclax monotherapy (n = 50, 62%) or in combination with a Bruton tyrosine kinase inhibitor (BTKi) (n = 16, 20%), an anti-CD20 monoclonal antibody (n = 11, 14%), or other active agents at 12 US academic medical centers. Patients had high-risk disease features including Ki67 >30% (61%), blastoid/pleomorphic histology (29%), complex karyotype (34%), and TP53 alterations (49%), and received a median of 3 prior treatments including BTKis in 91%. Venetoclax alone or in combination resulted in an overall response rate …

Go to article

A Single F153sβ3 Mutation Causes Constitutive Integrin Αiibβ3 Activation In A Variant Form Of Glanzmann Thrombasthenia, Sevasti B Koukouritaki, Aye Myat M Thinn, Katrina J Ashworth, Juan Fang, Haley S Slater, Lily M Du, Huong Thi Thu Nguyen, Xavier Pillois, Alan T Nurden, Christopher J Ng, Jorge Di Paola, Jieqing Zhu, David A Wilcox Jul 2023

A Single F153sβ3 Mutation Causes Constitutive Integrin Αiibβ3 Activation In A Variant Form Of Glanzmann Thrombasthenia, Sevasti B Koukouritaki, Aye Myat M Thinn, Katrina J Ashworth, Juan Fang, Haley S Slater, Lily M Du, Huong Thi Thu Nguyen, Xavier Pillois, Alan T Nurden, Christopher J Ng, Jorge Di Paola, Jieqing Zhu, David A Wilcox

2020-Current year OA Pubs

This report identifies a novel variant form of the inherited bleeding disorder Glanzmann thrombasthenia, exhibiting only mild bleeding in a physically active individual. The platelets cannot aggregate ex vivo with physiologic agonists of activation, although microfluidic analysis with whole blood displays moderate ex vivo platelet adhesion and aggregation consistent with mild bleeding. Immunocytometry shows reduced expression of αIIbβ3 on quiescent platelets that spontaneously bind/store fibrinogen, and activation-dependent antibodies (ligand-induced binding site-319.4 and PAC-1) report β3 extension suggesting an intrinsic activation phenotype. Genetic analysis reveals a single F153Sβ3 substitution within the βI-domain from a heterozygous T556C nucleotide substitution of ITGB3 exon …

Go to article

Lessons Learned Creating Microbiology Laboratory Demonstration Videos, Marnie Imhoff, Linsey Donner Jul 2023

Lessons Learned Creating Microbiology Laboratory Demonstration Videos, Marnie Imhoff, Linsey Donner

Innovations in Health Sciences Education Journal

Microbiology laboratory classes are designed to allow students to apply knowledge gained during lectures and become proficient in laboratory skills. Students are introduced to procedures for working with and identifying microorganisms. Instructors must prepare students to perform and interpret the necessary testing procedures to be successful. Laboratory demonstration videos provide students with a first-person, unobstructed demonstration on how to perform laboratory techniques. The videos can be used as a visual learning tool to supplement courses with an in-person laboratory session or as a component in online learning. This article describes the creation of instructional microbiology laboratory demonstration videos.

Go to article

Aurora Residency Programs House Staff Roster, 2006-2007, Advocate Aurora Health Jul 2023

Aurora Residency Programs House Staff Roster, 2006-2007, Advocate Aurora Health

Historical Documents - Combined

St. Luke's Medical Center: The house staff roster dated from July 2006 - June 2007, for the Aurora Residency Programs at St. Luke's Medical Center.

Go to article

Aurora Residency Programs Aurora Sinai Medical Center House Staff Roster, 2006-2007, Advocate Aurora Health Jul 2023

Aurora Residency Programs Aurora Sinai Medical Center House Staff Roster, 2006-2007, Advocate Aurora Health

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: The house staff roster dated from July 2006 - June 2007 for the Aurora Residency Programs at Aurora Sinai Medical Center.

Go to article

Aurora Residency Programs Aurora Sinai Medical Center House Staff Roster, 2010-2011, Advocate Aurora Health Jul 2023

Aurora Residency Programs Aurora Sinai Medical Center House Staff Roster, 2010-2011, Advocate Aurora Health

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: The house staff roster dated from July 2010 - June 2011 for the Aurora Residency Programs at Aurora Sinai Medical Center.

Go to article

Aurora Residency Programs House Staff Roster, 2010-2011, Advocate Aurora Health Jul 2023

Aurora Residency Programs House Staff Roster, 2010-2011, Advocate Aurora Health

Historical Documents - Combined

St. Luke's Medical Center: The house staff roster dated from July 2010 - June 2011, for the Aurora Residency Programs at St. Luke's Medical Center.

Go to article

泰尔指数在评分者间信度中的应用:与组内相关系数的比较, 潘 天舒, 阴 悦 Jul 2023

泰尔指数在评分者间信度中的应用:与组内相关系数的比较, 潘 天舒, 阴 悦

Chinese/English Journal of Educational Measurement and Evaluation | 教育测量与评估双语期刊

本文建议应用泰尔(Theil)指数比率于评分者间信度。我们讨论了其理论基础，并使用 真实数据进行了检验。研究结果表明，组内相关系数和泰尔指数比率结果之间的相关性 很高。但是，组内相关系数的估计可能会因评分者之间的某些极端分歧而低估评分者间 信度，比泰尔指数比率更容易受到这些极端分歧的影响。鉴于泰尔指数比率在某种程度 上克服了组内相关系数的局限性，至少在某些条件下，例如，当数据中存在奇异值，很 难估计方差分量，或者组内相关系数低估了评分者间信度的时候，泰尔指数比率提供了 评估评分者间信度的另一种方法。

Go to article

An Application Of Theil Indexes For The Interrater Reliability: A Comparison With Intraclass Correlations, Tianshu Pan, Yue Yin Jul 2023

An Application Of Theil Indexes For The Interrater Reliability: A Comparison With Intraclass Correlations, Tianshu Pan, Yue Yin

Chinese/English Journal of Educational Measurement and Evaluation | 教育测量与评估双语期刊

This study proposes to apply the Theil-index ratios for the interrater reliability. We discuss the theoretical foundations and examine its function empirically using real data. Our analyses show that Theil-index rations and intraclass correlation (ICC) estimates are highly correlated. However, ICC may underestimate the interrater reliability by some extreme disagreement among raters and be more likely to be influenced by the extreme disagreement. As Theil-index ratios overcome the limitations of ICC to some degree, it seems that Theil-index ratios provide an alternative to evaluating interrater reliability, at least under certain conditions, e.g., when outliers exist in the data, it is …

Go to article

Two New Species Of The Remarkable Scorpion Genus Megacormus Karsch, 1881 (Scorpiones: Euscorpiidae), Rolando Teruel, František Kovařík, Graeme Lowe, František Šťáhlavský Jul 2023

Two New Species Of The Remarkable Scorpion Genus Megacormus Karsch, 1881 (Scorpiones: Euscorpiidae), Rolando Teruel, František Kovařík, Graeme Lowe, František Šťáhlavský

Euscorpius

Two new species of the very interesting euscorpiid scorpion genus Megacormus Karsch, 1881, are herein described from eastern Mexico. Both had been previously misidentified in the published literature, one as Megacormus segmentatus Pocock, 1900, the other as Megacormus granosus (Gervais, 1844), but the direct comparison of adults of both sexes to adult topotypes from all members of the genus currently accepted as valid taxa, revealed solid morphological characters that warrant their recognition as distinct taxa. Both new species seem also to be endemics with a small distribution area, but apparently not restricted to a single locality. This addition raises the …

Go to article

Book Review On Methods, Methodologies, And Perspectives In The Humanities And Social Sciences: With Particular Reference To Islamic Studies - A Critical Rationalist Interpretation (By Ali Paya), Nevad Kahteran Jul 2023

Book Review On Methods, Methodologies, And Perspectives In The Humanities And Social Sciences: With Particular Reference To Islamic Studies - A Critical Rationalist Interpretation (By Ali Paya), Nevad Kahteran

Comparative Philosophy

No abstract provided.

Go to article

Book Review On Creating A Shared Morality: The Feasibility Of Ethical Constructivism (By Heather Salazar), Karin Brown Jul 2023

Book Review On Creating A Shared Morality: The Feasibility Of Ethical Constructivism (By Heather Salazar), Karin Brown

Comparative Philosophy

No abstract provided.

Go to article

Causality, Agency, And Moral Responsibility In Nikaya Buddhism, Soo Lam Wong Jul 2023

Causality, Agency, And Moral Responsibility In Nikaya Buddhism, Soo Lam Wong

Comparative Philosophy

In this paper, I aim to examine the relationship between the Buddhist notions of causality and agency, the questions of whether the Buddhist notion of causality affirms causal determinism and whether the Buddhist notion of agency affirms libertarian free will, the implications of the Buddhist notions of causality and agency for moral responsibility, and the implications of the Buddhist rejection of the metaphysical self for agency and moral responsibility. My claim is that although the question of whether the early Buddhist notions of causality and agency affirm causal determinism and libertarian free will respectively remains open, they are compatible with …

Go to article

Zhuang Zi And The “Greatest Joyousness”: Wang Fuzhi’S Approach, John R. Williams Jul 2023

Zhuang Zi And The “Greatest Joyousness”: Wang Fuzhi’S Approach, John R. Williams

Comparative Philosophy

The present article presents Wang Fuzhi 王夫之 (1619-1692 C.E.)’s reading of the eighteenth chapter of the Zhuang-Zi 莊子 (ZZ) by looking at his entry from Zhuang-Zi-Tong 莊子通 and other key glosses from Zhuang-Zi-Jie 莊子解. The philosophical upshot, I aim to show, is that Wang takes ZZ as presenting the consummation of “the greatest joyousness” (zhi-le 至樂) as requiring getting rid of joyousness as one’s desideratum. Using Derek Parfit’s work as a point of reference, I aim to show that this is not paradoxical or even inconsistent or even (directly or indirectly) self-defeating but is instead an interesting instance of …

Go to article

Daoist Freedom, Psychological Hygiene, And Social Criticism, Yun Tang Jul 2023

Daoist Freedom, Psychological Hygiene, And Social Criticism, Yun Tang

Comparative Philosophy

The article explores the inner logic and defining features of Daoist freedom. It argues that Daoist freedom can be meaningfully understood as psychological hygiene, and it suggests that Daoist xuan-jie (懸解) can be rendered possible only if one can rid oneself of intensional suffering—an idea ultimately inspired by Friedrich Nietzsche. This comparative approach enables the article contribute to the received way of understanding Daoist freedom by stressing its dialectics: by being at ease with one’s social and political environment, Daoist freedom demands social criticism, calling for room for people to be able to act spontaneously so that …

Go to article

The Dangers Of Re-Colonization: Possible Boundaries Between Latin American Philosophy And Indigenous Philosophy From Latin America, Jorge Sanchez-Perez Jul 2023

The Dangers Of Re-Colonization: Possible Boundaries Between Latin American Philosophy And Indigenous Philosophy From Latin America, Jorge Sanchez-Perez

Comparative Philosophy

The field of Latin American philosophy has established itself as a relevant subfield of philosophical inquiry. However, there might be good reasons to consider that our focus on the subfield could have distracted us from considering another subfield that, although it might share some geographical proximity, does not share the same historical basic elements. In this paper, I argue for a possible and meaningful conceptual difference between Latin American Philosophy and Indigenous philosophy produced in Latin America. First, I raise what I call Mariátegui’s Solidarity Challenge to show that there might be some neglectful treatment of the philosophical views of …

Go to article

No Place Like Home? A Dialogical Journey With Shlomo Biderman, Daniel Raveh Jul 2023

No Place Like Home? A Dialogical Journey With Shlomo Biderman, Daniel Raveh

Comparative Philosophy

This paper aims to think or rethink the concept of home as the contemporary avatar of the age-old question of self-identity. In dialogue with Shlomo Biderman, a comparative philosopher without borders who feels at home both in Jewish and Indian sources, the author assembles a philosophical jigsaw-puzzle made of different materials from different thinking traditions in attempt to reveal a new picture of home (and self) compatible with the changing world of immigration, relocation, dislocation and displacement, a world of emigrants, refugees and exiles, in which we live. The puzzle pieces include Plato’s cave, Isaiah Berlin’s “inner citadel”, Shmuel Yosef …

Go to article

Desc(Art) Or The 21st Century Cartesian Meditator, Andreea Mihali Jul 2023

Desc(Art) Or The 21st Century Cartesian Meditator, Andreea Mihali

Comparative Philosophy

In this paper I argue that the continued relevance of Descartes' philosophy for present-day concerns can be demonstrated by bringing to bear on his Meditations state-of-the-art developments in Informal logic and Argumentation theory, specifically Leo Groarke’s approach to multimodal arguments. I show that the meditative exercises that Descartes viewed as preconditions of establishing the metaphysical tenets of his system can be recast in present-day form using technological tools and media that we are familiar with. We will see that, due to the different historical and cultural contexts, the 21st century Cartesian meditating process can be: 1) technology-enhanced (a customizable, multimodal …

Go to article

Analyzing Nietzsche And Darwin In Search Of Origin Of Morality: The Evolving Perspective, Anirban Ghosh, Malabika Chakrabarti Jul 2023

Analyzing Nietzsche And Darwin In Search Of Origin Of Morality: The Evolving Perspective, Anirban Ghosh, Malabika Chakrabarti

Comparative Philosophy

It is generally believed that the greatest asset of human being is the moral values and according to theist such values have been infused in human by the creator. By accepting such view we simply get rid of any effort of searching the origin of morality or ethics and also transfer the responsibility of being ethical on the almighty. But when atheist denied God, the liability of being moral comes to human and also the significant question arose why we should be moral. Probably more important is the hunt for the origin of our morality. In this article we have …

Go to article

Dualism And Psychosemantics: Holography And Pansematism In Early Buddhist Philosophy, Federico Divino Jul 2023

Dualism And Psychosemantics: Holography And Pansematism In Early Buddhist Philosophy, Federico Divino

Comparative Philosophy

In the Indian philosophical debate, the relationship between the structure of knowledge and external reality has been a persistent issue. This debate has been particularly prominent in Buddhism, as evidenced by the earliest Buddhist attestations in the Pāli canon, where reality is described as a perceptual defection. The world (loka) is perceived through cognition (citta), and the theme of designation (paññatti) is central to the analysis of the Abhidhamma. Buddhism can be viewed as navigating between nominalism and cognitive normativism, as it deconstructs language, which is seen as an obfuscating element that separates the subject from the world. In this …

Go to article

Vol 14 No 2 Contents Page Jul 2023

Vol 14 No 2 Contents Page

Comparative Philosophy

No abstract provided.

Go to article

Vol 14 No 2 Information Page Jul 2023

Vol 14 No 2 Information Page

Comparative Philosophy

No abstract provided.

Go to article

Vol 14 No 2 Cover Page Jul 2023

Vol 14 No 2 Cover Page

Comparative Philosophy

No abstract provided.

Go to article

Promoting And Supporting English Language Study In The Usa, Cheryl Delk-Le Good Jul 2023

Promoting And Supporting English Language Study In The Usa, Cheryl Delk-Le Good

EnglishUSA Journal

EnglishUSA has officially kicked off its project “Promoting and Supporting English Language Study in the U.S.A” (PASELS-USA). The 3-year project, funded by the Department of Commerce Market Development Cooperator Program (MDCP), is intended to generate exports and support high quality U.S. jobs through funding and cooperation with several stakeholders worldwide. EnglishUSA’s initiatives will help increase the visibility of U.S.-based English language programs in targeted markets and highlight the importance of the industry within the larger field of international education and exports.

Go to article

First Prev Next Last