Digital Commons Network^™

Decade-Long Trends In Incidence Of Slipped Capital Femoral Epiphysis In The United States: A Nationwide Database Analysis Of Over 33 Million Patients, Aaron Singh, Travis Kotzur, Beltran Torres-Izquierdo, David Momtaz, Rishi Gonuguntla, Amir Human Hoveidaei, Ali Seifi, María Galán-Olleros, Pooya Hosseinzadeh

2020-Current year OA Pubs

PURPOSE: Slipped capital femoral epiphysis (SCFE) is a prevalent pediatric hip disorder linked to severe complications, with childhood obesity as a crucial risk factor. Despite the rising obesity rates, contemporary data on SCFE's epidemiology remain scarce in the United States. This study examined SCFE incidence trends and demographic risk factors in the United States over a decade.

METHODS: A decade-long (2011 to 2020) retrospective cohort study was undertaken using the Healthcare Cost and Utilization Project National Inpatient Sample. Patients aged younger than 18 years were identified and further analyzed if diagnosed with SCFE through ICD-9 or ICD-10 codes. Key metrics …

Epidemiology Of Dsm-5 Psychiatric Disorders In Kenyan Youth With Low And High Psychosis Risk, Rebekka H Sæle, David M Ndetei, Victoria N Mutiso, Daniel Mamah

2020-Current year OA Pubs

INTRODUCTION: There are few psychiatric epidemiology studies among Kenyan youth and fewer among those at high psychosis risk (HR).

METHODS: This study assessed the epidemiology of DSM-5 psychiatric disorders in HR and low-risk (LR) individuals to inform research and mental health services. 567 participants (aged 15-25) in HR (n = 246) and LR (n = 260) groups based on Washington Early Recognition Center Affectivity and Psychosis (WERCAP) Screen scores. Diagnostic Interview Schedule, version 5 (DIS-5) assessed DSM-5 psychiatric disorder prevalence. Diagnostic comorbidity and demographic relationships were investigated.

RESULTS: A higher prevalence was observed for all DSM-5 disorders in the HR …

Complement Regulation In The Eye: Implications For Age-Related Macular Degeneration, Georgia A. Wilke, Rajendra S. Apte

2020-Current year OA Pubs

Careful regulation of the complement system is critical for enabling complement proteins to titrate immune defense while also preventing collateral tissue damage from poorly controlled inflammation. In the eye, this balance between complement activity and inhibition is crucial, as a low level of basal complement activity is necessary to support ocular immune privilege, a prerequisite for maintaining vision. Dysregulated complement activation contributes to parainflammation, a low level of inflammation triggered by cellular damage that functions to reestablish homeostasis, or outright inflammation that disrupts the visual axis. Complement dysregulation has been implicated in many ocular diseases, including glaucoma, diabetic retinopathy, and …

Outcomes Of Limited Stage Primary Bone Diffuse Large B-Cell Lymphoma In The Rituximab Era: A Multicenter, Retrospective Study, Alexandra Rezazadeh, Nancy L. Bartlett, Et Al.

2020-Current year OA Pubs

Primary bone diffuse large B-cell lymphoma is a rare variant of extranodal non-Hodgkin lymphoma historically treated with induction chemotherapy followed by consolidative radiation therapy (RT). It remains unknown whether RT confers additional benefit following rituximab-based chemoimmunotherapy (CIT) induction in patients with limited stage disease. We conducted a multicenter, retrospective analysis of patients treated between 2005 and 2019 using rituximab-based CIT regimens with or without consolidative RT to discern whether consolidative RT adds benefit in patients with stage I-II disease that could be encompassed in one radiation field. A total of 112 patients were included: 78 received CIT and radiation (RT …

Astrocytes As A Mechanism For Contextually-Guided Network Dynamics And Function, Lulu Gong, Fabio Pasqualetti, Thomas Papouin, Shinung Ching

2020-Current year OA Pubs

Astrocytes are a ubiquitous and enigmatic type of non-neuronal cell and are found in the brain of all vertebrates. While traditionally viewed as being supportive of neurons, it is increasingly recognized that astrocytes play a more direct and active role in brain function and neural computation. On account of their sensitivity to a host of physiological covariates and ability to modulate neuronal activity and connectivity on slower time scales, astrocytes may be particularly well poised to modulate the dynamics of neural circuits in functionally salient ways. In the current paper, we seek to capture these features via actionable abstractions within …

A Prospective Phase I/Ii Clinical Trial Of High-Dose Proton Therapy For Chordomas And Chondrosarcomas, Sana S Dastgheyb, Alexandra D Dreyfuss, Michael J Lariviere, Jahan J Mohiuddin, Brian C Baumann, Jacob Shabason, Robert A Lustig, Jay F Dorsey, Alexander Lin, Sean M Grady, Bert W O'Malley, John Y K Lee, Jason G Newman, James M Schuster, Michelle Alonso-Basanta

2020-Current year OA Pubs

PURPOSE: The purpose of this study was to evaluate the feasibility and safety of dose-escalated proton beam therapy for treating chordomas and chondrosarcomas of the skull base and spine. Methods: A prospective cohort of 54 patients (42 with chordomas and 12 with chondrosarcomas) was enrolled between 2010 and 2018. The primary endpoints were feasibility and < 20% rate of acute grade ≥3 toxicity, and secondary endpoints included cancer-specific outcomes and toxicities. Patients were followed with magnetic resonance imaging or computed tomography at 3-month intervals. Proton beam therapy was delivered with doses up to 79.2 Gy using protons only, combination protons/intensity modulated radiation therapy (IMRT), or IMRT only.

RESULTS: Feasibility endpoints were met, with only 2 out of 54 patient radiation therapy plans failing to meet dosimetric constraints with protons, and 4 out of 54 experiencing a delay or treatment break >5 days, none for toxicities related to treatment. There were no grade …

Cardiovascular Safety Of Ozanimod In Patients With Ulcerative Colitis: True North And Open-Label Extension Analyses, Alessandro Armuzzi, Parakkal Deepak, Et Al.

2020-Current year OA Pubs

BACKGROUND & AIMS: Evaluating cardiovascular safety of sphingosine 1-phosphate (S1P) receptor modulators is warranted due to S1P receptor expression on cardiomyocytes and vascular endothelial cells. This analysis reports the cardiovascular safety of ozanimod, an S1P receptor modulator, in patients with moderately to severely active ulcerative colitis from the phase 3 True North (TN) and open-label extension (OLE).

METHODS: All patients who received ozanimod in TN (n = 796) and all eligible TN patients who entered the OLE (n = 823) were included. Cardiovascular-related adverse events were evaluated in patients with up to 146 weeks of ozanimod exposure (2219 patient-years), which …

Deconstructing Pathological Tau By Biological Process In Early Stages Of Alzheimer Disease: A Method For Quantifying Tau Spatial Spread In Neuroimaging, Stephanie Doering, Austin Mccullough, Brian A Gordon, Charles D Chen, Nicole Mckay, Diana Hobbs, Sarah Keefe, Shaney Flores, Jalen Scott, Hunter Smith, Stephen Jarman, Kelley Jackson, Russ C Hornbeck, Beau M Ances, Chengjie Xiong, Andrew J Aschenbrenner, Jason Hassenstab, Carlos Cruchaga, Alisha Daniels, Randall J Bateman, John C Morris, Tammie L S Benzinger, Et Al.

2020-Current year OA Pubs

BACKGROUND: Neuroimaging studies often quantify tau burden in standardized brain regions to assess Alzheimer disease (AD) progression. However, this method ignores another key biological process in which tau spreads to additional brain regions. We have developed a metric for calculating the extent tau pathology has spread throughout the brain and evaluate the relationship between this metric and tau burden across early stages of AD.

METHODS: 445 cross-sectional participants (aged ≥ 50) who had MRI, amyloid PET, tau PET, and clinical testing were separated into disease-stage groups based on amyloid positivity and cognitive status (older cognitively normal control, preclinical AD, and …

Contemporary Management Of Aneurysmal Subarachnoid Haemorrhage. An Update For The Intensivist, Chiara Robba, Katharina M Busl, Jan Claassen, Michael N Diringer, Raimund Helbok, Soojin Park, Alejandro Rabinstein, Miriam Treggiari, Mervyn D I Vergouwen, Giuseppe Citerio

2020-Current year OA Pubs

Aneurysmal subarachnoid haemorrhage (aSAH) is a rare yet profoundly debilitating condition associated with high global case fatality and morbidity rates. The key determinants of functional outcome include early brain injury, rebleeding of the ruptured aneurysm and delayed cerebral ischaemia. The only effective way to reduce the risk of rebleeding is to secure the ruptured aneurysm quickly. Prompt diagnosis, transfer to specialized centers, and meticulous management in the intensive care unit (ICU) significantly improved the prognosis of aSAH. Recently, multimodality monitoring with specific interventions to correct pathophysiological imbalances has been proposed. Vigilance extends beyond intracranial concerns to encompass systemic respiratory and …

Person-Centred Interventions To Improve Patient-Provider Relationships For Hiv Services In Low- And Middle-Income Countries: A Systematic Review, Laura K Beres, Ashley Underwood, Noelle Le Tourneau, Christopher Galloway Kemp, Gauri Kore, Lauren Yaeger, Jingjia Li, Alec Aaron, Claire Keene, Deepthi Priyanka Mallela, Banda A A Khalifa, Aaloke Mody, Sheree Renae Schwartz, Stefan Baral, Chanda Mwamba, Kombatende Sikombe, Ingrid Eshun-Wilson, Elvin H Geng, Marie-Claude C Lavoie

2020-Current year OA Pubs

INTRODUCTION: Person-centred care (PCC) has been recognized as a critical element in delivering quality and responsive health services. The patient-provider relationship, conceptualized at the core of PCC in multiple models, remains largely unexamined in HIV care. We conducted a systematic review to better understand the types of PCC interventions implemented to improve patient-provider interactions and how these interventions have improved HIV care continuum outcomes and person-reported outcomes (PROs) among people living with HIV in low- and middle-income countries.

METHODS: We searched databases, conference proceedings and conducted manual targeted searches to identify randomized trials and observational studies published up to January …

My Anesthesia Choice-Hf: Development And Preliminary Testing Of A Tool To Facilitate Conversations About Anesthesia For Hip Fracture Surgery, Mark D Neuman, Glyn Elwyn, Veena Graff, Viktoria Schmitz, Mary C Politi

2020-Current year OA Pubs

BACKGROUND: Patients often desire involvement in anesthesia decisions, yet clinicians rarely explain anesthesia options or elicit preferences. We developed My Anesthesia Choice-Hip Fracture, a conversation aid about anesthesia options for hip fracture surgery and tested its preliminary efficacy and acceptability.

METHODS: We developed a 1-page, tabular format, plain-language conversation aid with feedback from anesthesiologists, decision scientists, and community advisors. We conducted an online survey of English-speaking adults aged 50 and older. Participants imagined choosing between spinal and general anesthesia for hip fracture surgery. Before and after viewing the aid, participants answered a series of questions regarding key outcomes, including decisional …

Evaluation Of An Automated Von Willebrand Factor Glycoprotein Ibm Activity Assay Compared With 3 Alternative Von Willebrand Factor Activity Assays, Kenneth D Friedman, Martina Böhm-Weigert, Nicole Desimone, Dennis J Dietzen, Charles Eby, Cynthia Flickinger, Walter Hoyer, Mareike Kahl, Kandice Kottke-Marchant, Thomas L Ortel, Jürgen Patzke, Steven W Pipe, Morgan Stuart, Ayse Anil Timur, Ravindra Sarode

2020-Current year OA Pubs

BACKGROUND: To overcome deficiencies of the traditional von Willebrand factor (VWF) ristocetin cofactor activity assay (VWF:RCo), several automated assays for VWF platelet-binding activity have been developed. Information on the performance of these assays and their diagnostic utility remains limited.

OBJECTIVES: To validate the VWF:glycoprotein IbM assay INNOVANCE VWF Ac and compare it with an automated VWF:RCo assay as well as with an automated assay and a manual VWF:Ab assay and to generate reference ranges and analyze reproducibility of the VWF:glycoprotein IbM assay.

METHODS: Clinical sites enrolled healthy subjects and patients representing the intended use population; VWF activity assays were performed, …

Multi-Scale Cortical Bone Traits Vary In Females And Males From Two Mouse Models Of Genetic Diversity, Nicole Migotsky, Surabhi Kumar, John T Shuster, Jennifer C Coulombe, Bhavya Senwar, Adrian A Gestos, Charles R Farber, Virginia L Ferguson, Matthew J Silva

2020-Current year OA Pubs

Understanding the genetic basis of cortical bone traits can allow for the discovery of novel genes or biological pathways regulating bone health. Mice are the most widely used mammalian model for skeletal biology and allow for the quantification of traits that cannot easily be evaluated in humans, such as osteocyte lacunar morphology. The goal of our study was to investigate the effect of genetic diversity on multi-scale cortical bone traits of 3 long bones in skeletally-mature mice. We measured bone morphology, mechanical properties, material properties, lacunar morphology, and mineral composition of mouse bones from 2 populations of genetic diversity. Additionally, …

Broadway Theatre And The Covid-19 Pandemic: How Pre-Shutdown Longevity Impacted Production Success, Emmeline A. Lignowski

College Honors Program

On March 12, 2020 New York’s Broadway theaters halted performances due to the COVID-19 pandemic. After a year and a half of closure, Broadway finally reopened in August 2021, however, the market was drastically different from its pre-shutdown state. In the midst of a global pandemic, new productions faced increased challenges when trying to establish themselves on the Broadway stage, and even old productions struggled to recoup losses. In this paper, multiple regression analysis and a Cox proportional hazards model were used to test whether a production’s pre-shutdown longevity impacted its success after Broadway reopened. It was found that productions …

Herding Tigers Through A Reorganization: Practical Applications Of A Pandemic Reorganization, Michelle Colquitt, Renna Tuten Redd, Chris Vidas

Publications

Organizational change generally and reorganization especially can inherently cause feelings of nervousness and tension. This chapter discusses the moving parts of an organizational transformation to an R1 library and how communication and consensus-building efforts at multiple levels of the library are vital to this kind of transition. Prior to their library’s reorganization, the three authors worked on three different teams across two different units. After the reorganization, the authors were positioned in the same department within a new division in the library and faced the challenge of leading their teams in a new structural environment. Clemson University’s mascot is the …

Onc201 (Dordaviprone) In Recurrent H3 K27m-Mutant Diffuse Midline Glioma, Isabel Arrillaga-Romany, Andrew Cluster, Et Al.

2020-Current year OA Pubs

PURPOSE: Histone 3 (H3) K27M-mutant diffuse midline glioma (DMG) has a dismal prognosis with no established effective therapy beyond radiation. This integrated analysis evaluated single-agent ONC201 (dordaviprone), a first-in-class imipridone, in recurrent H3 K27M-mutant DMG.

METHODS: Fifty patients (pediatric, n = 4; adult, n = 46) with recurrent H3 K27M-mutant DMG who received oral ONC201 monotherapy in four clinical trials or one expanded access protocol were included. Eligible patients had measurable disease by Response Assessment in Neuro-Oncology (RANO) high-grade glioma (HGG) criteria and performance score (PS) ≥60 and were ≥90 days from radiation; pontine and spinal tumors were ineligible. The …

Computationally Restoring The Potency Of A Clinical Antibody Against Omicron, Thomas A Desautels, Suzanne M Scheaffer, Bradley Whitener, James B Case, Larissa B Thackray, Michael S Diamond, Et Al.

2020-Current year OA Pubs

The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs

Ligand Efficacy Modulates Conformational Dynamics Of The Μ-Opioid Receptor, Jiawei Zhao, Matthias Elgeti, Evan S O'Brien, Cecília P Sár, Amal Ei Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L Hubbell, Brian K Kobilka, Chunlai Chen

2020-Current year OA Pubs

The µ-opioid receptor (µOR) is an important target for pain management

A Precision Functional Atlas Of Personalized Network Topography And Probabilities, Robert J M Hermosillo, Ally Dworetsky, Babatunde Adeyemo, Caterina Gratton, Steven Petersen, Nico U F Dosenbach, Et Al.

2020-Current year OA Pubs

Although the general location of functional neural networks is similar across individuals, there is vast person-to-person topographic variability. To capture this, we implemented precision brain mapping functional magnetic resonance imaging methods to establish an open-source, method-flexible set of precision functional network atlases-the Masonic Institute for the Developing Brain (MIDB) Precision Brain Atlas. This atlas is an evolving resource comprising 53,273 individual-specific network maps, from more than 9,900 individuals, across ages and cohorts, including the Adolescent Brain Cognitive Development study, the Developmental Human Connectome Project and others. We also generated probabilistic network maps across multiple ages and integration zones (using a …

Phase Ii Trial Of Nab- Sirolimus In Patients With Advanced Malignant Perivascular Epithelioid Cell Tumors (Ampect): Long-Term Efficacy And Safety Update, Andrew J Wagner, Vinod Ravi, Richard F Riedel, Kristen Ganjoo, Brian A Van Tine, Rashmi Chugh, Lee Cranmer, Erlinda M Gordon, Jason L Hornick, Heng Du, Li Ding, Anita N Schmid, Willis H Navarro, David J Kwiatkowski, Mark A Dickson

2020-Current year OA Pubs

No abstract provided.

Geomorphic Analysis Of The Lower Arkansas River, Usa, Matthew Edwards

Graduate Theses and Dissertations

The Arkansas River is one of several large and important river systems stretching from the Rocky Mountains to the Mississippi River. It meanders across the Great Plains for ~1000 km before plunging into a mountain-bound valley, confined by the Ozarks to the north and Ouachitas to the south. The geologic history of the Arkansas River is poorly understood and crudely constrained to sometime between ~60 Ma and 100 Ka. Questions remain concerning its path(s), potential integration of the upper and lower sections, and overall history. The combination of knickpoint and chi (χ) mapping, tributary grain size analysis, tensile strength testing, …

Generalizations Of The Hardy Spaces And The Schwarz Boundary Value Problem, William L. Blair

Graduate Theses and Dissertations

We prove that many of the boundary properties associated with functions in the classic holomorphic Hardy spaces on the complex unit disk are present in Hardy classes of solutions to certain nonhomogeneous Cauchy-Riemann equations and higher-order generalizations of these equations. Also, we explicitly solve generalizations of the Schwarz boundary value problem on the complex unit disk and the upper-half plane when the boundary condition is in terms of boundary values in the sense of distributions.

Evaluation Of Late Season Potassium Applications To Arkansas Soybean, Carrie Ortel

Graduate Theses and Dissertations

Potassium (K) deficiency is one of the most important yield limiting factors in Arkansas soybean (Glycine max (L.) Merr.) production, although there are recently improved diagnostic and management opportunities available. However, several questions regarding the successful implementation of in-season K management in soybean production remain. Therefore, the research objectives were to (a) delineate the relationship between drought stress and K deficiency on soybean vigor, (b) identify the spatial dependencies of leaf-K concentrations at the production scale, (c) develop a leaf sampling protocol, (d) calibrate the fertilizer-K rate needed to correct varying levels of K deficiency at 15, 30, and …

Narrative Harmony: The Implementation Of Sound Design And Its Immersive Nature, Patrick Joseph Kelly

Graduate Theses and Dissertations

Sound is the first tool we are given to interact with the world we inhabit. Despite this, most discussion of narrative content revolves around written and visual storytelling. This often means audio is forgotten or overlooked during the production process. A phenomenon which is especially present amongst inexperienced content creators. By combining the transportation imagery model and Narrative Paradigm theories, a formula for analyzing narratives and immersion within the modern setting becomes prevalent. This combination would then lead to the creation of a four-episode podcast series was created where each episode was mixed to highlight a different component in sound …

The Effect Of Gentle Yoga On Average Daily Step Count, Francesca D'Agrosa

Graduate Theses and Dissertations

While walking is a widely accessible form of exercise that is highly effective at increasing overall wellness (Kadir et al., 2019; Zhao et al., 2015) and is a recommended form of physical activity for overweight and obese individuals, studies still indicate low step counts and levels of physical activity in people with obesity (Shultz et al., 2011). Sedentary overweight individuals may avoid walking for several reasons, including physiological and/or biomechanical factors that make walking more difficult. This study attempted to explore and address these avoidant behaviors by employing a single-case ABAB reversal design to implement bi-weekly gentle yoga sessions over …

Dyslexia Training: The Impact On The Perceptions And Knowledge-Base Of Pre-Professionals Preparing To Work In K-12 Educational Settings, Colby Fowler

Graduate Theses and Dissertations

This research explores the perceptions and understanding of dyslexia among first-year graduate students in speech-language pathology. Employing survey methodology, specifically a pre- and post-survey approach, this research investigates the attitudes and knowledge that the participants have in understanding and addressing dyslexia at the beginning of their graduate training. The study seeks to uncover the existing awareness, potential misconceptions, and the overall preparedness of these emerging professionals in dealing with individuals affected by dyslexia. Through a comprehensive survey analysis, the research aims to contribute valuable insights that can inform the development of targeted educational strategies and interventions within speech-language pathology programs, …

Ꮝꮘꮝꮩꮝꮣꭲ Ꭴᏸꭷꭲ Ꮢꭹ Ꭲꮎꭸ Ꭱꭿ: Reclamation Stories Of Indigenous Graduate Students At A Native American Serving Nontribal Institution, Sky B. Wildcat

Graduate Theses and Dissertations

The experiences of Indigenous graduate students in higher education are underrecognized in research and scholarship. Similarly, the experiences of Indigenous students, undergraduate or graduate, within Native American Serving NonTribal Institutions (NASNTIs) are largely excluded from research and scholarship. Although NASNTI designation is only dependent on the Indigenous undergraduate student population at an institution, the stories shared through this research signify the importance of considering Indigenous graduate students experiences at a NASNTI. The conceptual framework consisted of four core foundations as outlined by Kovach (2021), including ᎦᏚᏩ (ga-du-wa) knowledge, relational accountability, the Indigenous community of the NASNTI, and the situating of …

Vegetation Management During Establishment Of Native Grasses And Forb Plantings On Roadsides And Prairie Restoration, Rachel Woody-Pumford

Graduate Theses and Dissertations

North American prairies have been shrinking due to agricultural production, overgrazing, development of cities and towns, and climate change. However, integrated roadside vegetation management (IRVM) creates the opportunity to reestablish prairies along roadsides through planting native grasses and forbs. Utilizing postememergence (POST) herbicides registered for use along rights-of-way has the potential to remove invasive species and create space for newly establishing native grass and forb species. The use of clopyralid, florpyrauxifen-benzyl, metsulfuron, and quinclorac were found to be safe for use in plantings containing big bluestem (Andropogon gerardii Vitman) and butterfly milkweed (Asclepias tuberosa L.). However, florpyrauxifen-benzyl injured and stunted …

The Kids Aren’T Alright: Examining The Spatial Concentration Of Drug Crime Near Schools In Little Rock, Arkansas, Jason Neeley

Graduate Theses and Dissertations

In the last two decades, violence and death stemming from drug activity has become a concern to communities across the country. Increasingly, policymakers and law enforcement agencies have sought to understand where drug activity is located, including in and around schools, and why some places are more susceptible to drug problems than others. The current study explores two related questions: (1) How do drug crimes spatially pattern around schools? and, in turn, (2) What are the neighborhood-level predictors of the concentration of drug crime? Focusing on Little Rock, Arkansas, I examine the spatial distribution of drug offenses and overdoses within …

Ripperature: Crossing Gender And Genre, Gracie M. Bain

Graduate Theses and Dissertations

The murders of Polly Nichols, Annie Chapman, Elizabeth Stride, Catherine Eddowes, and Mary Jane Kelly in London in 1888 by the serial killer commonly known as “Jack the Ripper” were grotesque displays of violence against vulnerable women. As unsolved crimes, they have continuously been sensationalized and fictionalized since they occurred, beginning with dime novels like The Whitechapel Murders; Or, On the Track of a Fiend (1888) and continuing with novels like Stalking Jack the Ripper (2016). The sheer number of adaptations is staggering. This extensive adaptation process results in the mythologization of Jack the Ripper as a culture-text. This study …