Digital Commons Network^™

Inflammatory Myofibroblastic Tumor In A Patient With X-Linked Hypophosphatemia: A Case Of Occam's Razor Or Hickam's Dictum?, Farhan Chowdry, Kelsey M Miller, Ersan Altun, Sara E Wobker, Gary S Gottesman, Hikmat Al-Ahmadie, Tracy L Rose, Eric M Wallen, Matthew I Milowsky

2020-Current year OA Pubs

We present the case of a patient with X-Linked Hypophosphatemia (XLH) and an inflammatory myofibroblastic tumor (IMT) of the bladder which prompted further investigation into the possible relationship between XLH and IMT i.e. a case of Occam's Razor or Hickam's Dictum?

Explainable Ai-Based Deep-Shap For Mapping The Multivariate Relationships Between Regional Neuroimaging Biomarkers And Cognition, Puskar Bhattarai, Deepa Singh Thakuri, Yuzheng Nie, Ganesh B Chand

2020-Current year OA Pubs

BACKGROUND: Mild cognitive impairment (MCI)/Alzheimer's disease (AD) is associated with cognitive decline beyond normal aging and linked to the alterations of brain volume quantified by magnetic resonance imaging (MRI) and amyloid-beta (Aβ) quantified by positron emission tomography (PET). Yet, the complex relationships between these regional imaging measures and cognition in MCI/AD remain unclear. Explainable artificial intelligence (AI) may uncover such relationships.

METHOD: We integrate the AI-based deep learning neural network and Shapley additive explanations (SHAP) approaches and introduce the Deep-SHAP method to investigate the multivariate relationships between regional imaging measures and cognition. After validating this approach on simulated data, we …

Plecanatide Improves Abdominal Bloating And Bowel Symptoms Of Irritable Bowel Syndrome With Constipation, Darren M Brenner, Amol Sharma, Satish S C Rao, Adam P Laitman, Zeev Heimanson, Christopher Allen, Gregory S Sayuk

2020-Current year OA Pubs

BACKGROUND: Bloating is a bothersome symptom in irritable bowel syndrome with constipation (IBS-C).

AIM: To evaluate plecanatide efficacy in patients with IBS-C stratified by bloating intensity.

METHODS: Pooled phase 3 data (2 randomized, controlled IBS-C trials) from adults treated with plecanatide 3 mg or placebo for 12 weeks were analyzed. Patients were stratified post-hoc by baseline bloating severity (11-point scale: mild [≤ 5] and moderate-to-severe [> 5]). Assessments included change from baseline in bloating, abdominal pain, and complete spontaneous bowel movement (CSBM) frequency. Abdominal pain and bloating composite responders were defined as patients with ≥ 30% improvement from baseline in …

Mapping Brain Function In Adults And Young Children During Naturalistic Viewing With High-Density Diffuse Optical Tomography, Kalyan Tripathy, Morgan Fogarty, Alexandra M Svoboda, Mariel L Schroeder, Sean M Rafferty, Edward J Richter, Christopher Tracy, Patricia K Mansfield, Madison Booth, Andrew K Fishell, Arefeh Sherafati, Zachary E Markow, Muriah D Wheelock, Ana María Arbeláez, Bradley L Schlaggar, Christopher D Smyser, Adam T Eggebrecht, Joseph P Culver

2020-Current year OA Pubs

Human studies of early brain development have been limited by extant neuroimaging methods. MRI scanners present logistical challenges for imaging young children, while alternative modalities like functional near-infrared spectroscopy have traditionally been limited by image quality due to sparse sampling. In addition, conventional tasks for brain mapping elicit low task engagement, high head motion, and considerable participant attrition in pediatric populations. As a result, typical and atypical developmental trajectories of processes such as language acquisition remain understudied during sensitive periods over the first years of life. We evaluate high-density diffuse optical tomography (HD-DOT) imaging combined with movie stimuli for high …

Image Quality Characterization Of An Ultra-High-Speed Kilovoltage Cone-Beam Computed Tomography Imaging System On An O-Ring Linear Accelerator, Euidam Kim, Yang Kyun Park, Tianyu Zhao, Eric Laugeman, Xiaodong Neo Zhao, Yao Hao, Yoonsun Chung, Hugh Lee

2020-Current year OA Pubs

PURPOSE: The quality of on-board imaging systems, including cone-beam computed tomography (CBCT), plays a vital role in image-guided radiation therapy (IGRT) and adaptive radiotherapy. Recently, there has been an upgrade of the CBCT systems fused in the O-ring linear accelerators called HyperSight, featuring a high imaging performance. As the characterization of a new imaging system is essential, we evaluated the image quality of the HyperSight system by comparing it with Halcyon 3.0 CBCT and providing benchmark data for routine imaging quality assurance.

METHODS: The HyperSight features ultra-fast scan time, a larger kilovoltage (kV) detector, a more substantial kV tube, and …

Assessment Of Illness Severity In Adults Hospitalized With Acute Respiratory Tract Infection Due To Influenza, Respiratory Syncytial Virus, Or Human Metapneumovirus, Ann R Falsey, Edward E Walsh, Stacey L House, Yannick Vandendijck, Marita Stevens, Eric K H Chan, Gabriela Ispas

2020-Current year OA Pubs

BACKGROUND: Influenza, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) are common respiratory viruses causing similar symptoms. Optimal tools to assess illness severity for these viruses have not been defined. Using the Hospitalized Acute Respiratory Tract Infection (HARTI) study data, we report symptom severity by clinician-rated clinical severity scores (CSS) in adults with influenza, RSV, or hMPV and correlations between CSS and patient-reported outcomes (PROs).

METHODS: HARTI was a global epidemiologic study in adults hospitalized with acute respiratory tract infections. Patients were assessed at enrollment within 24 h of admission with CSS and twice during hospitalization with CSS, Respiratory Infection …

The Current And Future Role Of Insulin Therapy In The Management Of Type 2 Diabetes: A Narrative Review, Janet B Mcgill, Irl B Hirsch, Christopher G Parkin, Grazia Aleppo, Carol J Levy, James R Gavin

2020-Current year OA Pubs

Early initiation of intensive insulin therapy has been demonstrated to be effective in controlling glycemia and possibly preserving beta-cell function. Innovations in insulin formulations and delivery systems continue. However, we have seen an acceleration in the development of new classes of diabetes medications for individuals with type 2 diabetes and obesity, such as, for example, glucagon-like peptide-1 receptor agonists (GLP-1 RAs). These formulations have been shown to confer significant benefits in achieving good glycemic control with reduced hypoglycemia risk, weight loss, and cardiorenal protection. Therefore, it is reasonable to question whether there is still a role for insulin therapy in …

Seeing With New Eyes: A Costume Design Thesis On Wedding Band: A Love/Hate Story In Black And White, Jennifer Nielson Helms

Theses

AN ABSTRACT OF THE THESIS OFJennifer N. Helms, for the Master of Fine Arts degree in Theater Design, presented on March 26, 2024, at Southern Illinois University Carbondale. TITLE: SEEING WITH NEW EYES: A COSTUME DESIGN THESIS ON WEDDING BAND: A LOVE/HATE STORY IN BLACK AND WHITEMAJOR PROFESSOR: Wendi R. Zea This thesis document is a presentation and exploration of the process involving the costume design for Wedding Band: A Love/Hate Story in Black and White by Alice Childress. The play was produced in the Christian H. Moe Laboratory Theatre at Southern Illinois University Carbondale and ran from November 30 …

Selenate-Mediated Impacts On Mercury Methylation By Pseudodesulfovibrio Mercurii With Dissolved And Nanoparticulate Mercuric Nitrate, Md Sayeduzzaman Sarker

Theses

Inorganic mercury (Hg) is converted to potential neurotoxic methylmercury (MeHg) by a natural process called Hg methylation. MeHg can be biomagnified in the food chain, thus the consumption of Hg-contaminated fish contributes to harmful human health issues. Selenium (Se) inhibits the Hg bioavailability to the methylating bacteria by forming mercuric selenide (HgSe). Pseudodesulfovibrio mercurii, a type of sulfate-reducing bacteria (SRB) cultures were grown in anaerobic environments using an estuarine sulfate lactate growth medium to evaluate the effects of Hg concentrations, bacterial growth phase, and sodium selenate in the Hg methylation process. Bacterial cultures contained two types of mercuric (II) nitrate, …

Impact Of Early-Season Postemergence Co-Applications Of Foliar And Residual Herbicides On Crop Injury, Growth, And Yield In 2,4-D- And Dicamba-Tolerant Cotton (Gossypium Hirsutum L.), Logan N. Vallee

LSU Master's Theses

Studies were conducted in 2021 through 2023 at the LSU AgCenter Dean Lee Research and Extension Center near Alexandria, LA to determine the sensitivity of 2,4-D- or dicamba- tolerant cotton (Gossypium hirsutum L.) to an early season application of a Group 15 and foliar-only herbicides. Both studies were randomized complete block designs with a two-factorial arrangement of treatments with four replications. In the dicamba-tolerant cotton study, Factor A consisted of no foliar-herbicide, dicamba alone, glyphosate alone, or dicamba plus glyphosate. Factor B consisted of either no Group 15 residual herbicide, acetochlor, or S-metolachlor. In the 2,4-D- tolerant cotton …

Imperialism Unawareness: The Case Of Citizenship Construction Among Mexican Transnational Students, David Martinez-Prieto

Bilingual and Literacy Studies Faculty Publications

This study analyzes the impact that U.S. curricula have on Mexican transnational returnees. Specifically, this article focuses on the ideological development of the army and imperialism promoted in U.S. schools among Mexican populations. Using a framework that combines critical literacies, transnationalism, and Bourdieu’s concepts of habitus and doxa, this study draws on data from 24 interviews to Mexican transnational returnee students (n = 4), Mexican national professors (n = 4), and Mexican national students (n = 4) during their concurrence in a program of English language teaching in central Mexico. Findings suggest that, before returning to …

“I Want To Say The Right Thing”: Developing Translingual Literacy Practices Through Early Care Educator And University Researcher Partnerships, Angie Zapata, Mary Adu-Gyamfi, Adrianna González Ybarra

Bilingual and Literacy Studies Faculty Publications

An early care educator (ECE) and university collaborative model of teacher learning offers a distinct departure from common top-down models of professional development. Implementing a Social Design-Based Experiment, ECE and university partners collaborate to explore translingual picturebooks to address curricular inequities in their school settings. Featuring the experience of one white, middle-class ECE (Tamara) in a Midwest rural suburban school, we identify three critical components of this ECE and university researcher collaborative inquiry model: role of ECE as mentors and supporters, picturebooks as tools, and role of university partners as facilitators. Tamara’s experience highlights the critical components of the model, …

The Role Of Maternal Emotion Regulation In The Relationship Between Maternal Adverse Childhood Experiences (Aces), Negative Parenting, And Child Externalizing Behaviors, Maddison Knott

Master's Theses

Exploration of the effects of maternal Adverse Childhood Experiences (ACEs) on child externalizing behaviors were conducted in the proposed study. Subtypes of ACEs, such as household dysfunction and maltreatment, and their effects on child externalizing behaviors were also examined. Maternal ACEs have shown to have negative effects on their children through use of more negative parenting practices (NPP). However, the role of maternal difficulty in emotion regulation in the link between maternal ACEs, NPP, and child externalizing behaviors has not been previously shown in the literature. Thus, the present study aimed to examine these relations, specifically with NPP as a …

3d Analysis Of Fe-Ti Oxides And How They Affect Crystal-Plastic Deformation In Atlantis Bank, Southwest Indian Ridge, Sarah Hill

Master's Theses

This project focuses on the importance of the relationship between Fe-Ti oxide abundance and interconnectivity, and crystal-plastic deformation in Atlantis Bank, Southwest Indian Ridge by utilizing Micro-CT scanning. This was done through comparing the Micro-CT scans of 15 samples from three different Ocean Drilling Program and International Ocean Discovery Program drill holes using the Nikon NIS Advanced Research 3-D visualization program and producing plots and statistics from MATLAB. Results indicate a wide range of textures across a range of crystal-plastic fabric intensity and Fe-Ti oxide abundance. Ultimately, there was a generally positive relationship between depth, CPF intensity, and Fe-Ti oxide …

How Speech-Language Pathologists Account For Self-Determination Across The Progression Of Dementia, Emilee Mcgahee

Master's Theses

Dementia diagnoses are continuing to increase, with the number of diagnoses expected to reach 231 million globally by 2050 (World Alzheimer’s Report, 2019). With this comes a greater need for Speech-Language Pathologists (SLPs) who are able to best treat those who are diagnosed. Providing person-centered and strengths-based treatment approaches for people with dementia (PWD) has been proven to increase positive engagement responses while decreasing negative engagement responses (Skrainer et al., 2007). The primary objective of this research study was to assess treatment approaches used by SLPs in dementia care setting, along with how SLPs provide person-centered dementia treatment throughout the …

The Emerging Impacts Of Tourism On The Economy Of The Kingdom Of Saudi Arabia: A Comparative Study Of Oil And Tourism, Dania Abu Jabal

Master's Theses

Saudi Arabia was heavily dependent on oil, which caused an economic crisis due to the collapse of global oil prices. In 2016, the Saudi government launched Vision 2030 to diversify the Saudi economy and avoid dependence on oil revenues. One aim of Vision 2030 is to initiate numerous tourism initiatives to boost the tourism industry's economic impact, elevating its contribution from 3% of GDP to 10% by 2030.

This paper provides the necessary assessment to understand tourism's role and contribution to the Saudi economy and to determine whether the industry's growth is on the right track. Also, this paper also …

Outside Influence And Troop Deployment, Cara Wilson

Master's Theses

This paper examines the role that the President, the public, and the media played in troop deployment during the Afghanistan War. I hypothesized that each variable would influence troop deployment. Using a linear regression, I found that there is a positive relationship between the media and troop deployment. I concluded that media coverage did not influence troop deployment, but highlighted what was happening in Afghanistan. With the public, there is a negative relationship between the public and troop deployment. While troops increased, the public decreased in their support for the war. I conclude that the public did not have a …

Satellite Image Analysis And Sidewalk Classification Using Deep Learning Models, Subeksha Khanal

Master's Theses

Lack of sidewalk pavement can contribute to pedestrian fatalities and injuries in the USA. Although many researchers have conducted research on sidewalk detection, there are not many publicly available datasets that we would work on for sidewalk classification. In this study, I conducted classification tasks using pretrained CNN models including VGG16 and ResNet50. I extended these models by adding custom layers at the top of pretrained layers, employing various techniques to improve the classification accuracy.

The dataset comprises 4,731 images of sidewalk based on occlusion levels, including images where the sidewalk is visible from overhead and instances where sidewalk is …

Effects Of Identity And Competency-Based Rejection And Acceptance On Online Versus Face To Face Reaffiliation Preferences In Adults, August Namuth

Master's Theses

Humans are social animals, resulting in notable sensitivity to experiences of acceptance and rejection. This study extends existing research by considering whether rejection or acceptance based on identity uniquely influences reaffiliation interests. Participants recalled either an inclusionary or exclusionary experience (or a control state), which would have been based on their competency or identity. Following this experience, they indicated their interest in participating in virtual and in-person social activities. I hypothesized that identity-based rejection would foster an interest in reaffiliation through online activities due to the greater availability to join likeminded groups online compared to in person. Conversely, I hypothesized …

Disruption Of Polyunsaturated Fatty Acid Biosynthesis Drives Sting-Dependent Acute Myeloid Leukemia Cell Maturation And Death, Joice Kanefsky, Mary Basse, Judith Sokei, Orsola Di Martino, Liana Valin, Jeffrey A Magee, Francesca Ferraro, Stephen M Sykes, Et Al.

2020-Current year OA Pubs

The role of polyunsaturated fatty acid (PUFA) biosynthesis in acute myeloid leukemia (AML) remains largely undefined. A comparative expression analysis of 35 genes encoding fatty acid biosynthesis enzymes showed that fatty acid desaturase 1 (FADS1) was highly expressed across multiple AML subtypes relative to healthy controls and that elevated FADS1 expression correlates with worse overall AML patient survival. Functionally, shRNA-mediated inhibition of FADS1 reduced AML cell growth in vitro and significantly delayed leukemia onset in an AML mouse model. AML cell lines depleted of FADS1 arrested in the G1/S-phase of the cell cycle, acquired characteristics of myeloid maturation and subsequently …

Modulation Of Host Immunity By Sensory Neurons, Telma Saraiva-Santos, Tiago H Zaninelli, Felipe A Pinho-Ribeiro

2020-Current year OA Pubs

Recent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into this groundbreaking paradigm of neuroimmunology and discuss recent scientific evidence for the impact of sensory neurons on host responses against a wide range of pathogens and diseases, encompassing microbial infections and cancers. These valuable insights enhance our understanding of the interactions between the nervous and immune systems, and also pave the way for developing candidate innovative therapeutic interventions in immune-mediated diseases highlighting the importance of this interdisciplinary …

Understanding The ‘Dancing Nurses Of Tiktok’, Jacqueline Christianson, Sarah Marie Calonder, Jessica Leiberg, Virginia F. Riggs

College of Nursing Faculty Research and Publications

Judgment by nursing leaders is the wrong response.

Persistence And Evolution Of Pseudomonas Aeruginosa Following Initiation Of Highly Effective Modulator Therapy In Cystic Fibrosis, Catherine R. Armbruster, Yasmin K. Hilliam, Anna C. Zemke, Samar Atteih, Christopher Marshall, John Moore, Junu Koirala, Leah Krainz, Jordan R. Gaston, Stella E. Lee, Vaughn S. Cooper, Jennifer M. Bomberger

Biological Sciences Faculty Research and Publications

Today, more than 90% of people with cystic fibrosis (pwCF) are eligible for the highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy called elexacaftor/tezacaftor/ivacaftor (ETI) and its use is widespread. Given the drastic respiratory symptom improvement experienced by many post-ETI, clinical studies are already underway to reduce the number of respiratory therapies, including antibiotic regimens, that pwCF historically relied on to combat lung disease progression. Early studies suggest that bacterial burden in the lungs is reduced post-ETI, yet it is unknown how chronic Pseudomonas aeruginosa populations are impacted by ETI. We found that pwCF remain infected throughout their …

Guardians Of Precision: Advancing Radiation Protection, Safety, And Quality Systems In Nuclear Medicine, Francesco Giammarile, Peter Knoll, Jolanta Kunikowska, Diana Paez, Enrique Estrada Lobato, Miriam Mikhail-Lette, Richard Wahl, Ola Holmberg, May Abdel-Wahab, Andrew M Scott, Roberto C Delgado Bolton

2020-Current year OA Pubs

BACKGROUND: In the rapidly evolving field of nuclear medicine, the paramount importance of radiation protection, safety, and quality systems cannot be overstated. This document provides a comprehensive analysis of the intricate regulatory frameworks and guidelines, meticulously crafted and updated by national and international regulatory bodies to ensure the utmost safety and efficiency in the practice of nuclear medicine.

METHODS: We explore the dynamic nature of these regulations, emphasizing their adaptability in accommodating technological advancements and the integration of nuclear medicine with other medical and scientific disciplines.

RESULTS: Audits, both internal and external, are spotlighted for their pivotal role in assessing …

Validation Of A Stenotrophomonas Maltophilia Bloodstream Infection Prediction Score In The Hematologic Malignancy Population, Emily L Gill, Christian M Gill, Colleen Mcevoy

2020-Current year OA Pubs

Stenotrophomonas maltophilia (SM) bloodstream infections (BSIs) contribute to significant mortality in hematologic malignancy (HM) and hematopoietic stem cell transplantation (HSCT) patients. A risk score to predict SM BSI could reduce time to appropriate antimicrobial therapy (TTAT) and improve patient outcomes. A single center cohort study of hospitalized adults with HM/HSCT was conducted. Patients had ≥ 1 blood culture with a Gram-negative (GN) organism. A StenoSCORE was calculated for each patient. The StenoSCORE2 was developed using risk factors for SM BSI identified via logistic regression. Receiver operating characteristic (ROC) curves were plotted. Sensitivity and specificity for the StenoSCORE and StenoSCORE2 were …

Patient Engagement In Designing, Conducting, And Disseminating Clinical Pain Research: Immpact Recommended Considerations, Simon Haroutounian, Katherine J. Holzer, Et Al.

2020-Current year OA Pubs

In the traditional clinical research model, patients are typically involved only as participants. However, there has been a shift in recent years highlighting the value and contributions that patients bring as members of the research team, across the clinical research lifecycle. It is becoming increasingly evident that to develop research that is both meaningful to people who have the targeted condition and is feasible, there are important benefits of involving patients in the planning, conduct, and dissemination of research from its earliest stages. In fact, research funders and regulatory agencies are now explicitly encouraging, and sometimes requiring, that patients are …

Alport Syndrome And Alport Kidney Diseases - Elucidating The Disease Spectrum, Pongpratch Puapatanakul, Jeffrey H. Miner

2020-Current year OA Pubs

PURPOSE OF REVIEW: With the latest classification, variants in three collagen IV genes, COL4A3 , COL4A4 , and COL4A5 , represent the most prevalent genetic kidney disease in humans, exhibiting diverse, complex, and inconsistent clinical manifestations. This review breaks down the disease spectrum and genotype-phenotype correlations of kidney diseases linked to genetic variants in these genes and distinguishes "classic" Alport syndrome (AS) from the less severe nonsyndromic genetically related nephropathies that we suggest be called "Alport kidney diseases".

RECENT FINDINGS: Several research studies have focused on the genotype-phenotype correlation under the latest classification scheme of AS. The historic diagnoses of …

National Hiv And Hcv Screening Rates For Hospitalized People Who Use Drugs Are Suboptimal And Heterogeneous Across 11 Us Hospitals, Leo Knudsen Westgard, Laura R Marks, Et Al.

2020-Current year OA Pubs

BACKGROUND: To end the HIV and hepatitis C virus (HCV) epidemics, people who use drugs (PWUD) need more opportunities for testing. While inpatient hospitalizations are an essential opportunity to test people who use drugs (PWUD) for HIV and HCV, there is limited research on rates of inpatient testing for HIV and HCV among PWUD.

METHODS: Eleven hospital sites were included in the study. Each site created a cohort of inpatient encounters associated with injection drug use. From these cohorts, we collected data on HCV and HIV testing rates and HIV testing consent policies from 65 276 PWUD hospitalizations.

RESULTS: Hospitals …

Preexisting Diabetes And Breast Cancer Treatment Among Low-Income Women, Bayu Begashaw Bekele, Min Lian, Chester Schmaltz, Tracy Greever-Rice, Pratibha Shrestha, Ying Liu

2020-Current year OA Pubs

IMPORTANCE: Diabetes is associated with poorer prognosis of patients with breast cancer. The association between diabetes and adjuvant therapies for breast cancer remains uncertain.

OBJECTIVE: To comprehensively examine the associations of preexisting diabetes with radiotherapy, chemotherapy, and endocrine therapy in low-income women with breast cancer.

DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study included women younger than 65 years diagnosed with nonmetastatic breast cancer from 2007 through 2015, followed up through 2016, continuously enrolled in Medicaid, and identified from the linked Missouri Cancer Registry and Medicaid claims data set. Data were analyzed from January 2022 to October 2023.

EXPOSURE: Preexisting …

Avoiding Lead-Time Bias By Estimating Stage-Specific Proportions Of Cancer And Non-Cancer Deaths, Ellen T Chang, Christina A Clarke, Graham A Colditz, Allison W Kurian, Earl Hubbell

2020-Current year OA Pubs

PURPOSE: Understanding how stage at cancer diagnosis influences cause of death, an endpoint that is not susceptible to lead-time bias, can inform population-level outcomes of cancer screening.

METHODS: Using data from 17 US Surveillance, Epidemiology, and End Results registries for 1,154,515 persons aged 50-84 years at cancer diagnosis in 2006-2010, we evaluated proportional causes of death by cancer type and uniformly classified stage, following or extrapolating all patients until death through 2020.

RESULTS: Most cancer patients diagnosed at stages I-II did not go on to die from their index cancer, whereas most patients diagnosed at stage IV did. For patients …