Digital Commons Network^™

Riluzole As A Dual-Targeted Radiosensitizer For Osteosarcoma: Targeting Tumor Cells And Angiogenic Vasculature To Enhance Single High-Dose Radiotherapy Efficacy, Pooja P. Rao

Dissertations, Theses, and Capstone Projects

Osteosarcoma (OS), the most common primary bone malignancy of children and young adults, is intrinsically radioresistant, and outcomes for patients with unresectable or metastatic disease have not improved in over four decades. Single-dose radiation therapy (SDRT) is a potent modality against radioresistant, highly vascularized sarcomas, but its application in OS is constrained by dose-dependent normal tissue toxicity. Radiosensitizers achieving tumor control at lower doses therefore offer a direct route to widening the therapeutic window. Critically, OS radioresistance is not tumor-cell-autonomous. It emerges from two coordinated compartments: aberrant DNA repair and antioxidant capacity intrinsic to the tumor cell, and a radioprotective, …

Towards Identifying Fear And Safety Network States Across Sex, Rhonda Kolaric

Dissertations, Theses, and Capstone Projects

Post-traumatic stress disorder (PTSD) is a trauma- and stressor-related disorder with a lifetime prevalence of 5-6% in men, and 10-12% in women (National Center for PTSD). Generalized anxiety disorder (GAD) is a highly prevalent anxiety- and depression-related psychiatric disorder with a lifetime prevalence of 1-2% in men, and 3-4% in women (National Institutes of Health). Both of these disorders disproportionately affect women. A hallmark feature of both disorders is the maladaptive generalization of fear, in which defensive responses extend beyond the original traumatic or threatening stimulus to neutral or unrelated cues. This overgeneralization can become debilitating, disrupting cognitive, emotional, and …

Analysis Of Diterpenoid Alkaloids From American Aconitum Using Lc-Ms Metabolomic Methods, Yi Zhao

Dissertations, Theses, and Capstone Projects

Analysis of Diterpenoid Alkaloids from American Aconitum Using LC-MS Metabolomic Methods

by

Yi Zhao

Advisor: Edward J. Kennelly

Aconitum plants have been used as a traditional medicine in Asian countries for millennia to treat pain, rheumatism, syncope, fever, and other conditions. These therapeutic effects are mainly due to the bioactive diterpenoid alkaloids accumulated in the roots. Comparing with the large records and studies of Asian Aconitum and their medicinal use and the broad bioactive compounds, American Aconitum has been rarely investigated, not to mention how American Aconitum has been used medicinally. Based on previous phylogenetic and chemotaxonomic studies of Aconitum …

Architects Of Mrna Fate: Molecular And Cellular Control Of P-Body Organization In The Drosophilia Melanogaster Female Germline, Samantha Milano

Dissertations, Theses, and Capstone Projects

Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein condensates that regulate mRNA storage, translational repression, and decay. While the biochemical principles governing condensate assembly have been extensively studied in vitro, how P-body organization is established and dynamically regulated in vivo to control specific mRNA populations remains poorly understood. This dissertation investigated the molecular and cellular mechanisms that govern P-body architecture and function in the Drosophila melanogaster female germline. First, I identified the conserved LSm protein Trailer Hitch (Tral) as a central organizer of P-body architecture. Using quantitative confocal and super-resolution microscopy combined with chemical perturbations, I showed that Tral coordinates the …

Optimizing Nanoparticle Quality And Function In Applied Research, Angela M. Fried

Dissertations, Theses, and Capstone Projects

Radiology tests are among the fastest-growing categories of diagnostic analysis, and the gold standard of radiology tests is MRI.  MRI can be more informative if a contrast agent is used, and the standard of care contrasting agents (CA) are gadolinium-based.  Gadolinium is a heavy metal, toxic, and contraindicated for renal-compromised patients and the critically ill.  We propose a nanogel (NG) vehicle for an alternative organic CA.  CNs like 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL) and its derivatives have a variety of medical and industrial uses.  These cyclic CNs are stable, synthetic radicals with distinctive EPR/ESR signals and are helpful for various experimental applications, from …

The Role Of External Factors In Shaping Carbohydrate Conformational Landscapes, Murat Yaman

Dissertations, Theses, and Capstone Projects

Carbohydrates (glycans) are among the most structurally diverse biomolecules and participate in a wide range of biological processes, including molecular recognition, cell adhesion, immune response, host-pathogen interactions, and cellular signaling. Their biological functions are governed by a complex interplay between sequence, stereochemistry, conformational flexibility, and environmental factors. However, the structural heterogeneity and dynamic nature of glycans present significant challenges for both experimental characterization and theoretical modeling. In particular, the relationships between glycan structure, conformational dynamics, and the resulting potential energy surfaces remain incomplete.

This dissertation investigates how external factors modulate the potential energy surfaces of carbohydrates through a combination of …

"Is This America?" Fannie Lou Hamer, Humanity, Citizenship And The Struggle For Inclusive Democracy, Rhonda Chambers

Dissertations, Theses, and Capstone Projects

This thesis examines the life, political rhetoric, and enduring legacy of Fannie Lou Hamer, focusing on how her lived experiences under Jim Crow shaped the development of a distinctive political voice grounded in dignity, moral conviction, and democratic struggle.  Born into a Mississippi sharecropping family and denied the educational and political opportunities afforded to white Americans, Hamer developed an understanding of injustice through the realities of racial and economic oppression. Her experience with segregation, voter suppression, violence, and the Black church became central to the way she understood citizenship and was able to articulate the demands of freedom.

Through an …

Self-Organized Criticality In Biased Activated Random Walk, Joshua Meisel

Dissertations, Theses, and Capstone Projects

We demonstrate many of the conjectured universality and self-organized criticality (SOC) properties of the interacting particle system Activated Random Walk (ARW) in the setting of one-dimensional biased walks, as formulated for instance in Levine and Silvestri’s 2024 survey. Namely, there exists the same limiting critical state for two finite ARW models, as well as for the infinite model as the density approaches its critical value from below. Many of the desired properties hold, including heavy-tailed avalanches, but spatial correlations decay exponentially fast, a deviation from the SOC paradigm. Nonetheless, the obtained decay rate vanishes with the bias. Since the critical …

Panopticism And Pan-Oticism: Sound-Power From Foucault To Deleuze, Eric Dillenberger

Dissertations, Theses, and Capstone Projects

From Muzak to long range acoustic devices (LRADs), the contemporary proliferation of sonic technologies for governing moods, behaviors, and potentialities complicates the virtual absence of sound within Michel Foucault's primarily visual modality of disciplinary power in Discipline and Punish, exemplified by his central conceptual model of the panopticon. This thesis develops the corollary concept of pan-oticism to theorize the transformation of sound-power and its political function within administered sonic ecologies from Foucault's disciplinary societies to Gilles Deleuze's societies of control. Within the enclosed spaces constitutive of disciplinary societies, sound-power remains subordinated to Foucault's visual logic of panopticism, extending …

Parenthood And Re-Appraisal Of Childhood Maltreatment, Gayathri Cheran

Dissertations, Theses, and Capstone Projects

Background: Child maltreatment is associated with poorer physical and mental health outcomes across the lifespan.  Individuals’ appraisals of childhood maltreatment have important implications for these outcomes.  Appraisal is shaped by biological, psychological, and social-cultural factors, each of which undergoes change in parenthood.  Parenthood may prompt re-appraisal of childhood maltreatment in that being a parent evokes one’s experience of being parented.

Hypotheses: (1) Re-appraisal will be more likely in parents than non-parents.  In parents, re-appraisal will be more likely among: (2) primiparous parents, (3) parents with offspring of the same sex, and (4) parents who experienced maltreatment older in childhood (at …

Individual Intellectual Humility As A Predictor Of Perceived Information Sharing And Perceived Shared Leadership, Mary Beth Schroeder

Dissertations, Theses, and Capstone Projects

Cross-functional problem-solving teams are often assembled to address complex challenges by combining members’ distinct knowledge, ideas, and leadership capabilities. Yet teams do not always capitalize on these collective resources, because team members do not share the information they uniquely possess. This tendency to withhold information may be lessened by intellectually humility, a personality trait marked by a desire to close gaps in one’s knowledge and openness to what others contribute.

This study was originally designed to examine whether team intellectual humility relates to team creativity through information sharing and shared leadership. However, because of changes in the leadership development program …

Analyzing Harmony In Bulgarian And Bulgarian-Influenced Choral Arrangements From The Radio To The Screen, Annie Beliveau

Dissertations, Theses, and Capstone Projects

This dissertation investigates developments in arrangements and compositions made for Bulgarian choirs between 1950 and 2025. Arrangements from Bulgaria’s communist period (1944-1989), when musical radio broadcasts were tailored to promote nationalist sentiment, eventually reached the ears of foreigners on the other side of the Iron Curtain via recordings and ensemble tours. These obrabotki (arrangements of folk tunes) became popular in the “world music” boom of the 1980s, and foreign composers soon began to create new compositions for Bulgarian choirs to sing on albums and in scores for film, television, and video games. Over time, the uses of Bulgarian choir in …

The Effects Of Chronic Nicotine Exposure On Dopamine-Mediated Reinforcement Learning And Striatal Neurotransmission, Srishti Bose

Dissertations, Theses, and Capstone Projects

Tobacco is one of the most widely used substances across the United States; tobacco consumption is linked with several diseases and is one of the leading causes of preventable death in the country. Nicotine is the active substrate found in tobacco products, acting as a stimulant, which reinforces continued use. The introduction of tobacco-free options such as e-cigarettes and oral pouches has driven an increase in nicotine exposure across the population, especially in young adults. Acute nicotine use induces neuroadaptations in the mesolimbic dopaminergic system, which mediates reinforcement learning and addiction, that potentiates reward-related neurotransmission. Furthermore, there are clinical studies …

Retrieval Information From Working Memory: The Output Gating Framework Perspective And Its Underlying Processes, Chen Tiferet-Dweck

Dissertations, Theses, and Capstone Projects

Working memory (WM) keeps information accessible and available for further processing. However, not all the information we maintain in WM is behaviorally relevant at any given moment. To act effectively, we must dynamically control which memory representations are accessed to support ongoing goal-directed behavior. While the mechanisms underlying the selection of single items from WM access are comparatively well-studied, less is known about the principles governing multi-item access. Existing models of WM access imply that selecting multiple items should take longer and be more error-prone than single-item access. Yet, paradoxically, prior studies have shown that retrieving all items in WM …

‘A Sense Of The Sea’: Grassroots Culture, Care, And Endurance In Swansea, Cymru, Katy Clark

Dissertations, Theses, and Capstone Projects

This thesis argues that under present conditions, everyday political-aesthetic life is not only about resistance or reproduction but about holding: the work of keeping people, practices, and attachment present and oriented as conditions change. Holding takes the form of care and maintenance; as practices of making, assembling, and imagining; and as the work that keeps open the possibility of renewed attachment to public things and to each other. In the field, this was named as ‘a sense of the sea’, an affective register characterized by wariness, attunement, attentiveness, orientation, and endurance. I am calling this a fragile infrastructure of …

Urban Counterpoint (1992–2003): The Piano Music Of Ed Bland, Joseph Vaz

Dissertations, Theses, and Capstone Projects

This dissertation analyzes the piano music of Ed Bland, a politically and philosophically vocal composer active in the second half of the twentieth century, whose music draws on both the European and American twentieth-century avant-garde, and on African American vernacular music genres from ragtime to hip-hop. A review of the historical and personal context for these pieces, and a detailed examination of the compositional processes used in this music, work together to demonstrate how Bland thought about the relationship between different musical genres and languages.

Through this combination of theory of musical genre, historical and biographical study, and detailed analysis …

Waltzing Into Silence: Time, Space, And The Afterword In Ravel’S Valses Nobles Et Sentimentales In Comparison With Schumann’S Davidsbündlertänze, Op. 6, Nora I. Bartosik

Dissertations, Theses, and Capstone Projects

This dissertation undertakes an analysis of Maurice Ravel’s Valses nobles et sentimentales for piano against the backdrop of Robert Schumann’s Davidsbündlertänze, Op. 6, a work with significant parallels in structure, character, and narrative. The Davidsbündlertänze are examined as a model for the Valses nobles et sentimentales, with an emphasis on the two works’ use of the waltz form, their structure as a series of miniature dances composed as a single cohesive work, and their inclusion of an afterword, or epilogue. The analysis draws from the extensive literature on Schumann’s piano cycles in order to apply similar techniques to …

New York City Women’S Experiences With Perinatal Depression Inquiries, Diagnosis, And Treatment Initiation, Caterina Pisciotta

Dissertations, Theses, and Capstone Projects

Perinatal depression represents a significant public health concern, yet many women who experience depression symptoms during the perinatal period (either during pregnancy and/or after birth) do not receive treatment. Initiatives, such as ThriveNYC, were designed to address these gaps by screening and treating perinatal women for maternal depression, integrating screening into routine perinatal care and strengthening pathways to treatment. Using representative survey data collected between 2016 and 2021 via the Center for Disease Control and Prevention’s Pregnancy Risk Assessment Monitoring System (PRAMS), this study examined trends in perinatal depression inquiries (a proxy for “screening”) and postpartum diagnosis, as well as …

Ultrafast Spectroscopy Of Organic Materials In Strong Light–Matter Interaction And Terahertz Optics, Kamyar Rashidi

Dissertations, Theses, and Capstone Projects

Ultrafast spectroscopy is a powerful tool for investigating phenomena that occur on extremely short timescales and for probing ultrabroadband spectral responses enabled by its ultrashort laser pulses. These capabilities are essential for advancing both the fundamental understanding of light–matter interactions and the development of next-generation optoelectronic technologies. The first part of this thesis investigates the ultrafast dynamics of organic exciton–polaritons and their application to controlling molecular excited-state processes using momentum-resolved pump–probe spectroscopy. A major challenge in these systems is the dark-state problem, where photoexcitation predominantly populates long-lived excitonic reservoir states that obscure the in trinsic dynamics of the hybrid light–matter …

Mesoscopic Scaling Of Microwave Transmittance And Disorder-Induced Alignment, Israel Kurtz

Dissertations, Theses, and Capstone Projects

This thesis presents microwave measurements and numerical simulations of wave propagation and transmission through random mesoscopic waveguides. We analyze the scaling of mesoscopic microwave conductance, including departures from Ohm’s law near channel openings, which are frequencies at which new propagating modes enter the system, and the evolution of modal phase alignment within the medium, which leads to the observed diversity of transmission eigenvalues. We extend the transmission matrix formalism to all sample depths using the flux matrix, which relates the flux amplitude within the sample to the incident flux, and decompose the flux at each sample depth into forward- and …

Symphonies That "Sing": Reevaluating Voices And Vocality In Mahler's Early Symphonies, Erin M. Johnston

Dissertations, Theses, and Capstone Projects

This dissertation considers the role of vocal music in Gustav Mahler’s early symphonies through the lens of the composer’s practice of self-borrowing. Mahler was known to use his own pre-existing songs as the basis for large-scale movements in his early symphonies. While scholars have long recognized the close relationship between Mahler’s songs and symphonies, existing studies have emphasized questions of biography, intertextuality, musical meaning, and quotation rather than sustained analytical investigations of vocal influence in Mahler’s large-scale symphonic forms. The present study places this vocality at the forefront of its analyses, arguing that Mahler’s reworking of his own Lieder is …

Real-World Testing Of An Artificial Intelligence Conversational Agent As An Early Intervention And Support Tool In The Mental Health Referral Care Pathway: A Mixed-Methods Study, Rohit Shankar, Edward Meinert, Madison Milne-Ives, Emma Taylor, B Inkster, Alina Paik, Ananya Ananthakrishnan, Martin Orr, Ceire Costelloe

Peninsula Medical School

Background: The incidence of mental health concerns is growing, and demand for support is exceeding service capacity.Digital tools can provide additional support but risk causing harm if not delivered safely.Aims: We aimed to establish real-world evidence of the impact of an artificial intelligence-based mental healthconversational agent (Wysa) on depression and anxiety in patients waiting for Talking Therapies treatment.Methods: A mixed-methods randomized controlled trial was conducted with patients referred to Talking Therapies inthe Central and Northwest London NHS Foundation Trust. The primary outcome was change in depression severityover 12weeks between groups; secondary outcomes included anxiety severity, quality of life, safety, engagement, …

Serum Proenkephalin A (Penk) As An Emerging Biomarker Of Renal Failure And Its Association With Mineral, Endocrine, And Hematological Parameters, Zahraa H. K. Aljelawy, Haider Abdul-Moneem Al-Mothafer

Muthanna Medical Journal

Objective: Renal failure is related to metabolic and endocrine disorders, in particular chronic kidney disease-Mineral and Bone Disorder (CKD-MBD). In this study, the clinical utility of serum Proenkephalin A (PENK) as a novel renal biomarker was evaluated, and its changes and correlation matrix with established renal, mineral, bone and hematological parameters in patients with renal failure were studied. Materials and Methods: A case control study was performed including patients diagnosed clinically with renal failure and age and gender matched healthy controls. Venous blood samples were collected to analyze serum PENK, including urea, creatinine, parathyroid hormone (PTH), calcium, phosphate, Vitamin D, …

Assessment Of Glycemic Control Among Patients With Type 2 Diabetes Mellitus Attending A Tertiary Diabetes And Endocrinology Center In Sulaymania City/ Iraq, Lina Ali Al-Khafaji, Bahjat Abdulridha Alsaeedy

Muthanna Medical Journal

Introduction: The sociodemographic and clinical factors play a role in type 2 Diabetes Mellitus (T2DM) glycemic control.
Objectives: To assess glycemic control among T2DM patients and its association with sociodemographic and clinical factors.
Materials and methods: A prospective observational study of 210 patients with T2DM at a tertiary diabetes and endocrinology center in Sulaymania city/ Iraq, from April to November 2024. The study involved sociodemographic data, body mass index, blood pressure, and blood tests for HbA1c, fasting blood sugar, total cholesterol, LDL, HDL, triglycerides, blood urea and creatinine. The performed HbA1c tests were compared with baseline results to identify differences, …

Msmgoptimizer: An Open-Source R Package And Web Application For Streamlining Life Cycle Inventory Data Automation In Life Cycle Assessment, Philip Duah, Kwame Awuah-Offei

Mining Engineering Faculty Research & Creative Works

Life Cycle Inventory (LCI) compilation is indispensable in any Life Cycle Assessment (LCA) study, yet the preparation of inventory data for import into LCA software remains one of the most time‑consuming and error‑prone steps in the LCA workflow. LCI datasets frequently originate from multiple data sources and formats, necessitating automation tools that can optimize inventory data for direct use in LCA modeling platforms. SimaPro, the world's leading LCA modeling platform, for example, requires inventory data to be structured according to a proprietary CSV specification that is labour-intensive to prepare manually. Existing tools remain largely inaccessible to most researchers due to …

Review: Advancements In Fibrous Aerosol Filtration Across Experimental Analysis, Numerical Modeling, And Fabrication Technologies, Mirza Muhammad Zaid, Ashish Ranjan Kumar, Ashish Kakoria, Lina Zheng, Guang Xu

Mining Engineering Faculty Research & Creative Works

The increasing incidence of aerosol-related pulmonary diseases has intensified the need for efficient fibrous filtration technologies capable of capturing ultrafine particles with low pressure drop. Although nonwoven fibrous filters are widely used in medical, industrial, and ventilation systems, their complex internal structures and multiscale transport mechanisms remain insufficiently understood. This review examines the theoretical foundations of aerosol filtration, including single-fiber capture mechanisms and the concept of the most penetrating particle size. In addition, electrostatic interactions, including charge generation, transport, and stability, are incorporated to extend conventional mechanical filtration frameworks. Particular attention is given to flow–particle interactions within fibrous media. We …

The Role Of Mxene In The Process Of Sintering Hpcs To Ceramic, Jianyu Dai, Congjie Wei, Jeremy Watts, Chenglin Wu

Materials Science and Engineering Faculty Research & Creative Works

This work presents a detailed investigation of the pyrolysis and sintering processes of hydridopolycarbosilane (HPCS) polymers, focusing on the formation of β-silicon carbide (β-SiC) and the influence of Ti₃C₂–Ox in this process. Due to the computational limitations of density functional theory (DFT), molecular dynamics methods with appropriate potentials are necessary for simulating large-scale systems, however, the available potentials are limited when the modeling process evolves relatively more element types or complex chemical-mechanical processes are studied. In this work, a machine learning based MACE (Multi-body ACE) model is adopted and trained to accurately capture the polymer's transformation …

Examining The Impact Of Social Support On Academic Self-Efficacy In Black Doctoral Students In Psychology, Asia A. Hall

Dissertations

This study examined the relationship between perceived social support and academic self-efficacy, or academic confidence, among Black doctoral students in psychology programs at predominantly White institutions (PWIs). Grounded in self-efficacy theory, the study was designed to explore whether perceived social support was associated with and predictive of students’ academic confidence. A quantitative, cross-sectional design was used, and data were collected using adapted versions of the Multidimensional Scale of Perceived Social Support (MSPSS) and the Academic Self-Efficacy (ASE) scale. The sample consisted of 60 Black doctoral students enrolled in psychology programs at PWIs across the United States. Descriptive statistics indicated the …

Green Information Systems Adoption And Business Outcomes In Ugandan Smes: An Extended Theory Of Planned Behaviour Approach, Sonny Juma Nyeko, Samali Mlay, Cosmas Ogenmungu, Abdallah Ibrahim Nyero

Business Management Review

The study assesses the relationship between TPB antecedents and GIS business outcomes in SMEs, using an expanded TPB framework. Researchers gathered data from SMEs via a survey and analysed it using PLS-SEM. The framework used in the study explains 58.5% of the differences in GIS business outcomes. The results reveal that subjective norms, attitude, benefits, and obstacles are significant predictors of GIS business outcomes such as ecological IT practices, although perceived behavioural control displays an insignificant negative relationship. The study extended the TPB model by incorporating GIS benefits and GIS obstacles as additional factors influencing GIS adoption, business outcomes, …

Neural Symphony Of Flow Experience: Evidence For High-Dimensional Metastable Dynamics, Abdelrahman B.M. Eldaly, Kris Zhangguang Kang, Fiona Fui Hoon Nah, Leanne Lai Hang Chan, Keng Leng Siau, Xiao Fan Liu, Richard Huskey, Langtao Chen, Tejaswini Yelamanchili, René Weber

Business and Information Technology Faculty Research & Creative Works

Flow, an optimal experience characterized by deep immersion and engagement in an activity, has been extensively studied in behavioral research. However, its neural dynamic mechanism remains poorly understood. In a within-subject video gaming experiment, we captured neural activity underlying flow, boredom, and anxiety using a 64-channel electroencephalogram (EEG) system. Compared to boredom and anxiety, flow exhibits the highest global functional connectivity, metastability, and dimensionality of dynamic functional connectivity patterns, suggesting that flow is a highly adaptable process that is supported by high-dimensional neural dynamics. Unlike previous studies that focused on identifying static or localized brain activity, we examine the neural …