Digital Commons Network^™

Comparative Analysis Of Science And Technology Innovation Competitiveness In The Yellow River Basin, Weiyu Duan, Quanjing Wang, Kaihua Chen, Siqing Fang, Huiling Liang, Renhai Dai

Bulletin of Chinese Academy of Sciences (Chinese Version)

The assessment and comparison of the S&T innovation competitiveness among the provinces and regions in the Yellow River Basin are helpful to better utilize the supporting and leading role of S&T innovation in the ecological protection and high-quality development of the Yellow River Basin. Combined with the real characteristics of S&T innovation in the Yellow River Basin, the study considers five dimensions horizontally: S&T innovation input, S&T innovation output, S&T entrepreneurial condition, S&T innovation revenue, and S&T innovation influence. Vertically, it considers two types of indicators, namely, strength and efficiency, and constructs the index system of evaluation of S&T innovation …

Current Status, Challenges, And Policy Recommendations For Industrial Development In The Yellow River Basin, Chaokai Xue, Kaihua Chen, Quanjing Wang, Yujie Zhang, Xiaohui Qu, Mengfei Zhang, Haitao Ma

Bulletin of Chinese Academy of Sciences (Chinese Version)

The foundation for ecological protection and high-quality development in the Yellow River Basin lies in the rational development of industry. This study systematically analyzes the current state of industrial development in the Yellow River Basin, examining traditional industries, strategic emerging industries, and future industries. Based on this analysis, it identifies key issues and development directions. The study reveals that the industrial structure in the Yellow River Basin is unreasonable; traditional industries have short chains and high energy consumption; the cultivation of strategic emerging industries is inadequate and poorly aligned; and comprehensive planning for future industries is inadequate. Therefore, it is …

Research On Current Situation And Optimization Strategy Of Cross-Regional Scientific And Technological Innovation Cooperation In The Yellow River Basin, Gupeng Zhang, Wenbo Guo, Huiling Liang, Jingjing Zhang, Dongzhu Lu, Baorong Hou, Yan Liang, Weiyu Duan

Bulletin of Chinese Academy of Sciences (Chinese Version)

Realizing effective cross-regional innovation cooperation not only helps to enhance the overall scientific and technological innovation capabilities of the Yellow River Basin, but also is crucial for promoting the western development strategy and achieving industrial upgrading and leapfrogging in the western region. The innovation collaborative network composed of various enterprises, universities, and research institutes across different regions in the Yellow River Basin helps to break down information silos and help provinces and cities fully achieve information sharing in open scientific and technological innovation cooperation platforms. The cross-regional innovation collaborative network that have been constructed in the Yellow River Basin consists …

Digital Technologies Empower Innovative Development Governance Of The Yellow River Basin, Tara Qian Sun, Yingying Jia, Gaozuo Sun, Xixi Zhao, Rongping Mu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The application of digital technologies is the core driving force for innovating traditional development and realizing a leap in productivity. The innovative development governance of the Yellow River Basin is a complex social system, involving economic, social, and ecological aspects. Its key driving force is the profound influence of digital technologies. Focused on how digital technologies empower the innovative development governance of the Yellow River Basin, the development process, problems, and challenges are analyzed at different stages, from the digital Yellow River to the digital twin Yellow River. It is found that the governance of the Yellow River Basin still …

Study On Data Mining Of Hydrogen Energy Policy In China Based On Natural Language Processing Technology, Dongling Huang, Yuan Liu, Xiaoshuai Yuan, Guozhong Jin, Yuanhang Cai, Li Liu, Heng Cao, Wanjun Li, Rui Cai

Bulletin of Chinese Academy of Sciences (Chinese Version)

Report to the 20th National Congress of the CPC emphasized the importance of “working actively and prudently towards the goals of reaching peak carbon emissions and carbon neutrality”, as well as “speeding up the planning and development of a system for new energy sources”. As a green and low-carbon secondary energy source, hydrogen energy has multiple applications in promoting the large-scale and efficient use of renewable energy as well as energy substitution in the field of transportation. It can also accelerate decarbonization in industry, and as such, is an indispensable part of building a new energy system, reaching peak carbon …

Comparative Analysis And Insights Into R&D Mode Of Top Artificial Intelligence Companies In China And The Us, Xiyi Yang, Jia Jia, Xiaoyu Zhou, Shouyang Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Artificial intelligence (AI) is currently one of the most prominent fields in the technology industry, with China and the US being two global centers for AI research and development. However, the two countries differ in their development levels of the AI industry. In particular, the emergence of ChatGPT in 2022 has sparked extensive discussions regarding the capabilities and competitiveness of Chinese AI companies. This study analyzes over 120 000 AI invention patents approved in the past five years in both China and the US. Firstly, it constructs a multidimensional index based on AI patent features to identify the top 10 …

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Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

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Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

Accelerated Particle Swarm Optimization Algorithm For Efficient Cluster Head Selection In Wsn, Imtiaz Ahmad, Tariq Hussain, Babar Shah, Altaf Hussain, Iqtidar Ali, Farman Ali

All Works

Numerous wireless networks have emerged that can be used for short communication ranges where the infrastructure-based networks may fail because of their installation and cost. One of them is a sensor network with embedded sensors working as the primary nodes, termed Wireless Sensor Networks (WSNs), in which numerous sensors are connected to at least one Base Station (BS). These sensors gather information from the environment and transmit it to a BS or gathering location. WSNs have several challenges, including throughput, energy usage, and network lifetime concerns. Different strategies have been applied to get over these restrictions. Clustering may, therefore, be …

Diversity And Evolution Of Nitric Oxide Reduction In Bacteria And Archaea, Ranjani Murali, Laura A. Pace, Robert A. Sanford, Luce M. Ward, Mackenzie M. Lynes, Roland Hatzenpichler, Usha F. Lingappa, Woodward W. Fischer, Robert B. Gennis, James Hemp

Geosciences: Faculty Publications

With the advent of culture-independent techniques for studying environmental microbes, our knowledge of their diversity has exploded, uncovering unique organisms, pathways, and proteins carrying out important processes in the biosphere. Novel biochemical reactions are often proposed based on sequence data, but experimental validation is difficult and rare. In this work, we used environmental sequence data to find enzymes that produce the greenhouse gas N₂O from NO and validated our hypothesis with experiments. These new enzymes likely contribute to global N₂O fluxes and expand the breadth of nitrogen cycling. We also demonstrated that these enzymes evolved multiple …

Culture Or Power: The Eruption Of The Anglophone Crisis In Cameroon, Danielle Tagakou Talla

Dissertations and Theses

Located in Central West Africa, Cameroon has been the stage of a protracted conflict since 2016. The conflict called the "Anglophone crisis" is rooted in Cameroon colonial history. This is reflected in the composition of its population with a large majority of Francophones and only 20 percent of Anglophones. The subsequent thesis aims to examine the crisis between 2016 and 2022 and understand the shift in focus that happened in the early years of the conflict. Using a qualitative methodology, journal articles, books and recorded interviews will provide substantial sources to decipher the change from cultural focus to one of …

Uncovering The Dynamic Nature Of Fire Refugia Across Landscapes In Oregon's Western Cascades, Alec Scott Dyer

Dissertations and Theses

With increased fire activity, the presence of fire refugia is critical to support forest resiliency and mitigate large-scale vegetation conversion, however, the persistence of fire refugia within burn perimeters over time is uncertain. This study examines the dynamic nature of fire refugia by mapping the decline in forest cover over time, identifying spatiotemporal patch- and landscape-scale patterns and the biophysical drivers of delayed mortality following the 2020 Labor Day Fires occurring in Oregon’s western Cascades. After three years post-fire, delayed mortality accounted for an additional 8.5% of forest loss (total of 24,147 hectares in all five burns) compared to pre-fire …

Immune Responses To Mycobacterium Tuberculosis Infection In The Liver Of Diabetic Mice, Ali Badaoui, Kayvan Sasaninia, Aishvaryaa Shree Mohan, Abrianna Beever, Nala Kachour, Anmol Raien, Afsal Kolloli, Ranjeet Kumar, Santhamani Ramasamy, Selvakumar Subbian, Vishwanath Venketaraman

Student Publications

Individuals with uncontrolled diabetes are highly susceptible to tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) infection. Novel treatments for TB are needed to address the increased antibiotic resistance and hepatoxicity. Previous studies showed that the administration of liposomal glutathione (L-GSH) can mitigate oxidative stress, bolster a granulomatous response, and diminish the M. tb burden in the lungs of M. tb-infected mice. Nonetheless, the impact of combining L-GSH with conventional TB treatment (RIF) on the cytokine levels and granuloma formation in the livers of diabetic mice remains unexplored. In this study, we evaluated hepatic cytokine profiles, GSH, and tissue pathologies …

Enabling Tobacco Treatment For Gastroenterology Patients Via A Novel Low-Burden Point-Of-Care Model, Suha Abushamma, Li-Shiun Chen, Jingling Chen, Nina Smock, Giang Pham, Chien-Huan Chen

2020-Current year OA Pubs

BACKGROUND & AIM: Smoking is a major risk factor for multiple gastrointestinal cancers, and adversely affects peptic ulcer disease, gastroesophageal reflux, pancreatitis and Crohn's disease. Despite key recommendations for diagnosing and treating tobacco use disorder in healthcare settings, the degree to which this is implemented in Gastroenterology (GI) clinics is unknown. We aimed to assess our providers' practices, identify barriers for implementing evidence-based smoking cessation treatments, and address these barriers by implementing a novel low-burden point of care Electronic health record-enabled evidence-based tobacco treatment (ELEVATE), in GI clinics.

METHODS: An online survey was distributed to clinic gastroenterologists. ELEVATE module training …

Improving Emergency Medicine Resident Pediatric Lumbar Puncture Procedural Performance Through A Brief Just-In-Time Video Intervention, Sarayna S Mcguire, Alexander S Finch, Jenna M Thomas, Octavio Lazaro, Sara A Hevesi, Aidan F Mullan, Jim L Homme

2020-Current year OA Pubs

BACKGROUND: Emergency medicine (EM) trainee comfort level with lumbar puncture (LP) has decreased over time due to changing practice guidelines, particularly amongst pediatric patients. We implemented a "just in time" (JIT) brief educational video based on a previously published LP Performance Scoring Checklist to improve trainee efficiency and competence in LP performance.

METHODS: Our pilot quasi-experimental study took place January-June 2022 within a large, academic Midwestern emergency department (ED) with an established 3-year EM residency program. All 9 interns performed a timed diagnostic LP on an infant LP model in January, scored according to the LP Performance Scoring Checklist. In …

Understanding Social Impacts Of Major Disruptions From The Perspective Of Destination Access, Manika Rana Bhat

LSU Master's Theses

Major disruptions (like public health crises and extreme weather events) significantly impact human mobility and travel patterns. This study investigates the social impacts of major disruptions on human mobility from the perspective of accessing destinations. This study used a large-scale dataset from SafeGraph and focused on analyzing the impacts of COVID-19 and Hurricane Ida on destination access in Louisiana. The findings of the temporal plots indicated that the impact magnitude of Hurricane Ida was much smaller than that of the COVID-19 pandemic but still resulted in hardship on destination access. During COVID-19, it was found that parishes with limited active …

Navigating Undergraduate Medical Education: The Impact Of Enhanced Mentorship Pairing At A New Medical School, Shawn Izadi

School of Medicine Publications

Introduction

Transitioning into medical school is challenging, particularly in the first year, with a notable support gap. This study aimed to evaluate a mentorship program at a new medical school.

Methods

Initiated in 2017 at the University of Texas Rio Grande Valley School of Medicine, the mentorship program had two iterations: initial random pairings and subsequent formative pairings based on matching criteria. A mixed-methods approach assessed its effectiveness in supporting first-year students.

Results

Of 109 first-year students, 76% completed a 6-month survey. Both classes primarily had male mentees with varied interests in primary or specialty care. No significant demographic differences …

First Multicenter Study Evaluating The Utility Of The Benchmarktm Bmxtm 81 Large-Bore Access Catheter In Neurovascular Interventions, Ahmed Abdelsalam, Hayes B. Fountain, Ian A. Ramsay, Evan M. Luther, Mohammad Mahdi Sowlat, Michael A. Silva, Ameer E. Hassan, Aman B. Patel, Tiffany Eatz, Pradeep Joseph

School of Medicine Publications

Introduction

This study is the first multicentric report on the safety, efficacy, and technical performance of utilizing a large bore (0.081″ inner diameter) access catheter in neurovascular interventions.

Methods

Data were retrospectively collected from seven sites in the United States for neurovascular procedures via large bore 0.081″ inner diameter access catheter (Benchmark BMX81, Penumbra, Inc.). The primary outcome was technical success, defined as the access catheter reaching its target vessel. Safety outcomes included periprocedural device-related and access site complications.

Results

There were 90 consecutive patients included. The median age of the patients was 63 years (IQR: 53, 68); 53% were …

Troponin: Think Before Testing, Shakirat Ganiyu, Fatimah Bello, Danielle Stone, Gregory Ruhnke, James Stone

School of Medicine Publications

This is a high-value care-based quality improvement project that was carried out to decrease inappropriate troponin testing in the emergency department (ED) of a tertiary health institution in the United States with the goal of promoting evidence-based practices, minimizing waste, and enhancing the quality of care.

Creating Sustainable School And Home Gardens: Native Bee Homes, Daniel Findlay, Kaitlin Campbell, Rita Hagevik, Kathy Cabe Trundle

All Current Publications

This fact sheet is part of a series about creating sustainable school and home gardens. It provides information and resources on bee homes, including learning about bees and how to help them, how to obtain and install bee homes, fall cocoon care, fun facts, and resources.

Validating Risk Prediction Models For Multiple Primaries And Competing Cancer Outcomes In Families With Li-Fraumeni Syndrome Using Clinically Ascertained Data, Nam H Nguyen, Elissa B Dodd-Eaton, Jessica L Corredor, Jacynda Woodman-Ross, Sierra Green, Banu K Arun

Faculty, Staff and Student Publications

PURPOSE: There exists a barrier between developing and disseminating risk prediction models in clinical settings. We hypothesize that this barrier may be lifted by demonstrating the utility of these models using incomplete data that are collected in real clinical sessions, as compared with the commonly used research cohorts that are meticulously collected.

MATERIALS AND METHODS: Genetic counselors (GCs) collect family history when patients (ie, probands) come to MD Anderson Cancer Center for risk assessment of Li-Fraumeni syndrome, a genetic disorder characterized by deleterious germline mutations in the

RESULTS: For prediction of deleterious

CONCLUSION: We describe a study that fills in …

Electronic Patient-Reported Outcome-Based Symptom Management Versus Usual Care After Lung Cancer Surgery: Long-Term Results Of A Multicenter, Randomized, Controlled Trial, Wei Dai, Yaqin Wang, Jia Liao, Xing Wei, Zhen Dai, Yangjun Liu, Cecilia Pompili, Hongfan Yu, Yang Pu, Yuqian Zhao, Bangrong Cao, Qifeng Wang, Wenhong Feng, Yuanqiang Zhang, Fang Liu, Yuanle Deng, Jin Zhou, Juan Li, Shaohua Xie, Run Xiang, Xiang Wang, Bo Tian, Xiaozun Yang, Bin Hu, Xiaoqin Liu, Tianpeng Xie, Xiaojun Yang, Xiang Zhuang, Guibin Qiao, Qiang Li, Qiuling Shi

Faculty, Staff and Student Publications

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.We previously reported superior symptom control of electronic patient-reported outcome (ePRO)-based symptom management after lung cancer surgery for up to 1 month postdischarge. Here, we present the long-term results (1-12 months) of this multicenter, randomized trial, where …

Elderly Mice With History Of Acetaminophen Intoxication Display Worsened Cognitive Impairment And Persistent Elevation Of Astrocyte And Microglia Burden, Celso S G Catumbela, Rodrigo Morales

Faculty, Staff and Student Publications

Acetaminophen (APAP) is a leading cause of acute liver failure. The effect of APAP metabolite's effects in the periphery are well characterized; however, associated consequences in the brain remain poorly understood. Animal studies on this subject are few and reveal that frequent APAP intake can trigger cerebral abnormalities that vary depending on the subject's age. Alarmingly, experimental efforts have yet to examine associated consequences in elderly hosts, who correspond to the highest risk of medication overload, impaired drug clearance, and cognitive deficits. Here, we interrogated the cerebral and peripheral pathology of elderly mice submitted to monthly episodes of APAP intoxication …

Engaging Nursing Students With A Behaviour Change Intervention Designed To Improve Their Lifestyle, Daniela Austin, Jon May

School of Psychology

Background: In common with the general population, nursing students struggle to live a healthy lifestyle. Aims: To recruit students in a behaviour change intervention, using the COM-B model of behaviour change to understand engagement. Methods: Nursing students were invited to complete an online survey assessing height, weight, BMI, physical activity, lifestyle satisfaction, motivation for leading a healthy life, and quality of life. Those identified as overweight or not physically active were offered a webinar and social media site to support setting personal goals and boosting motivation to achieve a healthy lifestyle. Findings: 25% of invited students engaged with the interventions, …

Erratum: Gut Microbiota Composition Is Associated With The Efficacy Of Delta-24-Rgdox In Malignant Gliomas, Natalie M Meléndez-Vázquez, Teresa T Nguyen, Xuejun Fan, Andrés R López-Rivas, Juan Fueyo, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma, the most common primary brain tumor, has a 6.8% survival rate 5 years post diagnosis. Our team developed an oncolytic adenovirus with an OX-40L expression cassette named Delta-24-RGDOX. While studies have revealed the interaction between the gut microbiota and immunotherapy agents, there are no studies linking the gut microbiota with viroimmunotherapy efficacy. We hypothesize that gut bacterial signatures will be associated with oncolytic viral therapy efficacy. To test this hypothesis, we evaluated the changes in gut microbiota in two mouse cohorts: (1) GSC-005 glioblastoma-bearing mice treated orally with indoximod, an immunotherapeutic agent, or with Delta-24-RGDOX by intratumoral injection and …

Development Of An Effective Predictive Screening Tool For Prostate Cancer Using The Claritydx Machine Learning Platform, M Eric Hyndman, Robert J Paproski, Adam Kinnaird, Adrian Fairey, Leonard Marks, Christian P Pavlovich, Sean A Fletcher, Roman Zachoval, Vanda Adamcova, Jiri Stejskal, Armen Aprikian, Christopher J D Wallis, Desmond Pink, Catalina Vasquez, Perrin H Beatty, John D Lewis

Faculty, Staff and Student Publications

The current prostate cancer (PCa) screen test, prostate-specific antigen (PSA), has a high sensitivity for PCa but low specificity for high-risk, clinically significant PCa (csPCa), resulting in overdiagnosis and overtreatment of non-csPCa. Early identification of csPCa while avoiding unnecessary biopsies in men with non-csPCa is challenging. We built an optimized machine learning platform (ClarityDX) and showed its utility in generating models predicting csPCa. Integrating the ClarityDX platform with blood-based biomarkers for clinically significant PCa and clinical biomarker data from a 3448-patient cohort, we developed a test to stratify patients' risk of csPCa; called ClarityDX Prostate. When predicting high risk cancer …

Sensory Asic3 Channel Exacerbates Psoriatic Inflammation Via A Neurogenic Pathway In Female Mice, Zhichao Liu, An-Ran Ren, Jian-Fei Lu, Qin Jiang, Ying Li, Michael X Zhu, Zhirong Yao, Yang Tian, Xin Qi, Wei-Guang Li, Tian-Le Xu

Faculty, Staff and Student Publications

Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerbates psoriatic inflammation through a sensory neurogenic pathway. Global or nociceptor-specific Asic3 knockout (KO) in female mice alleviates imiquimod-induced psoriatic acanthosis and type 17 inflammation to the same extent as nociceptor ablation. However, ASIC3 is dispensable for IL-23-induced psoriatic inflammation that bypasses the need for nociceptors. Mechanistically, ASIC3 activation induces the activity-dependent release of calcitonin gene-related peptide (CGRP) from sensory neurons to promote neurogenic inflammation. Botulinum neurotoxin A and CGRP antagonists prevent sensory neuron-mediated …

Understanding Enterprise Data Warehouses To Support Clinical And Translational Research: Impact, Sustainability, Demand Management, And Accessibility, Boyd M Knosp

Faculty, Staff and Student Publications

OBJECTIVES: Healthcare organizations, including Clinical and Translational Science Awards (CTSA) hubs funded by the National Institutes of Health, seek to enable secondary use of electronic health record (EHR) data through an enterprise data warehouse for research (EDW4R), but optimal approaches are unknown. In this qualitative study, our goal was to understand EDW4R impact, sustainability, demand management, and accessibility.

MATERIALS AND METHODS: We engaged a convenience sample of informatics leaders from CTSA hubs (n = 21) for semi-structured interviews and completed a directed content analysis of interview transcripts.

RESULTS: EDW4R have created institutional capacity for single- and multi-center studies, democratized access …

A Taxonomy For Advancing Systematic Error Analysis In Multi-Site Electronic Health Record-Based Clinical Concept Extraction, Nansu Zong, Anamika Kumari, Feifan Liu, Sicheng Zhou, Rui Zhang, Chenyu Li, Yanshan Wang, Jennifer St Sauver, Hongfang Liu, Sunghwan Sohn

Faculty, Staff and Student Publications

Background: Error analysis plays a crucial role in clinical concept extraction, a fundamental subtask within clinical natural language processing (NLP). The process typically involves a manual review of error types, such as contextual and linguistic factors contributing to their occurrence, and the identification of underlying causes to refine the NLP model and improve its performance. Conducting error analysis can be complex, requiring a combination of NLP expertise and domain-specific knowledge. Due to the high heterogeneity of electronic health record (EHR) settings across different institutions, challenges may arise when attempting to standardize and reproduce the error analysis process.

Objectives: This study …

Implementation Of A Health Information Technology Safety Classification System In The Veterans Health Administration’S Informatics Patient Safety Office

Faculty, Staff and Student Publications

Objective: Implement the 5-type health information technology (HIT) patient safety concern classification system for HIT patient safety issues reported to the Veterans Health Administration's Informatics Patient Safety Office.

Materials and methods: A team of informatics safety analysts retrospectively classified 1 year of HIT patient safety issues by type of HIT patient safety concern using consensus discussions. The processes established during retrospective classification were then applied to incoming HIT safety issues moving forward.

Results: Of 140 issues retrospectively reviewed, 124 met the classification criteria. The majority were HIT failures (eg, software defects) (33.1%) or configuration and implementation problems (29.8%). Unmet user …