Digital Commons Network^™

Discovery Of Runs-Of-Homozygosity Diplotype Clusters And Their Associations With Diseases In Uk Biobank

Faculty, Staff and Student Publications

Runs-of-homozygosity (ROH) segments, contiguous homozygous regions in a genome were traditionally linked to families and inbred populations. However, a growing literature suggests that ROHs are ubiquitous in outbred populations. Still, most existing genetic studies of ROH in populations are limited to aggregated ROH content across the genome, which does not offer the resolution for mapping causal loci. This limitation is mainly due to a lack of methods for the efficient identification of shared ROH diplotypes. Here, we present a new method, ROH-DICE (runs-of-homozygous diplotype cluster enumerator), to find large ROH diplotype clusters, sufficiently long ROHs shared by a sufficient number …

The Relationship Between Medication Beliefs, Patient Activation, And Self-Rated Health In Patients Taking Oral Anticancer Agents

Faculty, Staff and Student Publications

Purpose: Patients on oral anticancer agent (OAA) therapies have the autonomy to manage their cancer treatments in home settings. However, patients may not have adequate knowledge, confidence, or ability to effectively manage OAA-related consequences, which can significantly impact their treatment and health outcomes. This study aims to identify the associations between medication beliefs, patient activation, and self-rated health (SRH) among oncology patients taking OAAs and explore the potential mediation effects of patient activation on the relationship between medication beliefs and SRH.

Methods: A secondary data analysis was conducted on cross-sectional data from 114 patients who were diagnosed with breast, colorectal, …

Study Of Prognostic Splicing Factors In Cancer Using Machine Learning Approaches

Faculty, Staff and Student Publications

Splicing factors (SFs) are the major RNA-binding proteins (RBPs) and key molecules that regulate the splicing of mRNA molecules through binding to mRNAs. The expression of splicing factors is frequently deregulated in different cancer types, causing the generation of oncogenic proteins involved in cancer hallmarks. In this study, we investigated the genes that encode RNA-binding proteins and identified potential splicing factors that contribute to the aberrant splicing applying a random forest classification model. The result suggested 56 splicing factors were related to the prognosis of 13 cancers, two SF complexes in liver hepatocellular carcinoma, and one SF complex in esophageal …

Identifying Forms Of After-Hours Information Communication Technology Use And Their Role In Psychological Detachment: An Episodic Approach, Adela Chen, Samantha A. Conroy, Tori L. Crain

Psychology Faculty Publications and Presentations

Employees increasingly conduct work outside of traditional work hours via information communication technologies (ICTs). There is a need to understand how after-hours ICT use relates to well-being, given that such connectivity has become unavoidable. We implement an episodic, event-contingent design to evaluate the association between different ICT media (i.e., e-mail, phone call, chat app, short message service) and the within-person outcomes of psychological detachment as partially mediated by task productivity. A daily diary survey was collected over three consecutive workdays to capture after-hours ICT use. Daily surveys were completed by 498 individuals, with a total of 1494 episodes being captured …

No Consensus In Nh On Appropriate Punishment For Trump, Few Expect A Prison Sentence 6/21/2024, Unh Survey Center

All UNH Survey Center Polls

New Hampshire residents are divided on the appropriate punishment for former President Donald Trump in the wake of his conviction in the New York "hush money" case. Most Democrats think a prison sentence is appropriate but less than a third of Independents and very few Republicans agree. Most Granite Staters do not think Trump will be sent to prison and are split on whether Trump's appeals will overturn his conviction. On another topic, a majority support President Biden's executive action concerning illegal immigration, with Republicans more likely than Democrats to be in support.

Half Of Vermonters Feel Prison Is Appropriate Punishment For Trump In "Hush Money" Case 6/21/2024, Unh Survey Center

All UNH Survey Center Polls

Half of Vermont residents think sentencing Donald Trump to prison is an appropriate punishment in his New York "hush money" case but few expect this to occur. Residents are divided on other potential punishments such as house arrest, community service, parole, or a small fine. Nearly half of Vermont Republicans think any punishment is inappropriate. Bipartisan majorities support President Biden's executive action concerning illegal immigration.

Mainers Divided On Appropriate Punishment, Chances Of Successful Appeal In Trump "Hush Money" Case 6/21/2024, Unh Survey Center

All UNH Survey Center Polls

Maine residents do not agree on an appropriate punishment for Donald Trump in the wake of his conviction in the New York "hush money" case and are split on the likelihood of a successful appeal in the case. Democrats think prison, a large fine, and house arrest are appropriate punishments but nearly half of Republicans think no punishment, even a small fine, is appropriate. Majorities of Democrats and Republicans in the state support President Biden's executive action concerning illegal immigration. However, approval of Biden's overall job performance has fallen since April.

Ijrtp Volume 12(I) Table Of Contents, Kevin A. Griffin, Razaq Raj, Carlos Fernandes

International Journal of Religious Tourism and Pilgrimage

Table of contents for Volume 12(i) of International Journal of Religious Tourism and Pilgrimage

Recent Trends In The Development Of Jewish Life And Heritage Tourism In Trani, Italy, Andrea Corsale

International Journal of Religious Tourism and Pilgrimage

This paper focuses on the recent revival of Jewish religious and cultural activities in the coastal town of Trani, in Southern Italy, after several centuries of substantial interruption. The specific events which led to the re-establishment of an institutional Jewish community and the restoration and reclamation of the local synagogues, along with the renewed visibility of the well-preserved Jewish district, of Medieval origins, are unique to this case study. However, at the same time, they reflect similar phenomena of restoration of Jewish sites and revival of Jewish communities in southern and eastern Europe, and beyond. As the case study analysis …

Business Operators’ Perception Of The Impact Of The Portuguese Way Of St. James, Paula Remoaldo, Eduardo Duque, Vítor Ribeiro, José Cadima Ribeiro, Hélder Silva Lopes, Sandro Ferreira, Cátia Faria

International Journal of Religious Tourism and Pilgrimage

This research aims to analyse business operators’ perception of the impact of the Portuguese Way of St. James and to assess the landscape situation along a total section of 115 kilometres. Perceptions were collected in a survey of 112 small operators between 2020 and 2021. The diversity and singular components of the landscape make it a pleasant route to experience, where pilgrims have the possibility to improve wellbeing, and enjoy the landscape. Operators have profited from the significant increase in the number of pilgrims walking along the Way and claim that they aim to continue their operations.

Review Of: The Politics Of Religious Tourism, Edited By Dino Bozonelos And Polyxeni Moira, Maria Laura Gasparini

International Journal of Religious Tourism and Pilgrimage

Review of: Bozonelos, D. and Moira. P. (Eds.) (2023) The Politics of Religious Tourism. Published by CABI, Oxfordshire, UK, 2023. Hardback: ISBN-13: 9781800621718, 248 pages - DOI: 10.1079/9781800621732.0000. Price: EUR 115.00 (Hardcover).

Review Of: The Bloomsbury Handbook Of Religion And Heritage In Contemporary Europe, Edited By Todd H. Weir And Lieke Wijnia, Maaike De Jong

International Journal of Religious Tourism and Pilgrimage

Review of: Weir, T.H. & Wijnia, L. (Eds.) (2023) The Bloomsbury Handbook of Religion and Heritage in Contemporary Europe, Bloomsbury Publishing, United Kingdom, 472 pages, £117 (Hardcover), ISBN: ‎ 978-1350251380.

Whose Opinions Do We Listen To? The Influence Of Online Product Ratings And Price On Consumers, David Ackerman, Jing Hu, Barbara L. Gross

Journal of Applied Marketing Theory

User-generated reviews have become important to consumers in evaluating market offerings and making purchase decisions. This study takes an overall look at the evolving sources of information from which consumers draw to get information about products and services and focuses specifically on an electronics product, a smart phone. We examine the influence of online product ratings and reviews on consumers. Results from data analysis found that online consumer ratings may have more of an impact on consumers than do the ratings of experts. Consumers were more likely to purchase products receiving high ratings from consumers despite receiving low ratings from …

Emerging Themes Regarding Customer Perception Of A Third-Party Online Food Delivery Provider And The Implications For Operators, Shian-Lih Chen Mccain, Jeff Lolli, Emma Liu

Journal of Applied Marketing Theory

This study discusses third-party online food delivery providers' (OFDPs) continuing dominance post-pandemic and provides recommendations for providers and foodservice operators by analyzing customer comments regarding a third-party OFDP. Thematic Analysis, a data-driven inductive approach, was applied in this study to identify four emergent themes. 1) App Technology- Oriented Quality Attributes, 2) App Service-Oriented Quality Attributes, 3) Delivery Person’s Performance, and 4) Restaurant Food Quality. Technology-Oriented Quality Attributes had the highest frequency of mentions (533), followed by Deliverer’s Performance (531), Service-Oriented Quality Attributes (524), and Restaurant Food Quality (115) for a total of 1,703 mentions of which 461(27%) were positive and …

Understanding Course Success In Mandated Online Learning: The Role Of Computer And Computer- Mediated Communication Anxiety, Chris Zimmer

Journal of Applied Marketing Theory

Amidst the COVID-19 pandemic, many universities shifted to fully online learning. This study contributes to the existing online learning literature by examining the connection between course success, student engagement, and levels of computer and computer-mediated communication anxiety. The research delves into understanding the impact of anxiety on course engagement and the relationship between engagement and overall course success. Regression analyses were used to test hypotheses, revealing an interaction between computer anxiety and computer-mediated communication anxiety. The study underscores the importance of student engagement with course materials, particularly for assignments that require higher-order thinking. In contrast, objective quizzes and tests that …

When Consumer Brand Advocacy Goes Bad: A Study Of Key Drivers Of Extreme, Negative Activism, Esta D. Shah, Julia E. Blose, Reagan C. Kilpatrick

Journal of Applied Marketing Theory

This paper uses an active, two-party political landscape in the U.S. as a testing ground to study the effects of an individual’s level of perceived political identification, fantasy proneness, and conspiracy mentality as possible antecedents of extreme, negative activism (e.g. attacking a police officer) undertaken to protect one’s brand community. Two independent, national surveys conducted one week prior to the November 2020 presidential election (N=481) and again in March 2021 after the presidential transition (N=465) allowed us to study the relationship between the three variables among U.S. citizens with liberal or conservative perceived political identifications, and measure likelihood to engage …

Cellular Energy Cycle Mediates An Advection-Like Forward Cell Flow To Support Collective Invasion, Jian Zhang, Jenna Mosier, Yusheng Wu, Logan Waddle, Paul V. Taufelele, Wenjun Wang, Heng Sun, Cynthia A. Reinhart-King

Biomedical Engineering Faculty Publications and Presentations

Collective cell migration is a model for nonequilibrium biological dynamics, which is important for morphogenesis, pattern formation, and cancer metastasis. The current understanding of cellular collective dynamics is based primarily on cells moving within a 2D epithelial monolayer. However, solid tumors often invade surrounding tissues in the form of a stream-like 3D structure, and how biophysical cues are integrated at the cellular level to give rise to this collective streaming remains unclear. Here, it is shown that cell cycle-mediated bioenergetics drive a forward advective flow of cells and energy to the front to support 3D collective invasion. The cell division …

Report On 2023-2024 Compliance With Continuous Quality Improvement Legislation, University Of Northern Iowa

Institutional Effectiveness & Planning Documents

A report provided to the Iowa Board of Regents regarding continuous improvement processes in courses at the University of Northern Iowa.

Moral Distress And Pediatric Palliative Care., Sunny Jeong, Angie Knackstedt, Jennifer Linebarger, Brian S. Carter

Manuscripts, Articles, Book Chapters and Other Papers

Moral distress is a complex phenomenon whereby a person feels tension, constraint, or conflict with an action or circumstance because it goes against their individual or the perceived collective (e.g., community, organizational, or professional association's) moral stance. In pediatric healthcare settings, managing and mitigating feelings of moral distress can be particularly difficult to navigate through because of the intricate dynamics between the pediatric patient, parent and/or legal guardians, and clinicians. The proactive integration of an experienced pediatric palliative care (PPC) team can be an appropriate step toward reducing clinicians feeling overwhelmed by various case-specific and team management issues that contribute …

Taylor Lajeunesse, Petitioners/Appellants V. City Of Cottonwood Heights, City Of Holladay, Respondents/Appellees : Brief Of Appellee, Utah Supreme Court

Utah Supreme Court Briefs (2021– )

On appeal from the Third Judicial District Court, Salt Lake County, Honorable Robert P. Faust, District Court No. 230902854

Andrew Deiss (7184) John Robinson Jr. (15247) David Ferguson (16043) DEISS LAW, P.C. Attorneys for Appellant

Matthew D. Church (15574) Kendra M. Brown (16409) MANNING CURTIS BRADSHAW & BEDNAR PLLC Attorneys for Appellees

Protocol For Preclinical Evaluation Of Locoregionally Delivered Car T Cells In Patient-Derived Xenograft Models Of Brain Tumors, Ailsa Greppi, John Anderson, Nabil Ahmed, Michael D Taylor, Laura K Donovan

Faculty, Staff and Students Publications

Here, we present a protocol for preclinical evaluation of locoregionally delivered CAR T cells in patient-derived xenograft models of primary, metastatic, and recurrent brain tumors. We provide instructions for isolating peripheral blood mononuclear cells (PBMCs), producing CAR T cells in conjunction with locoregional delivery, and preclinical trial design and analysis involving CAR T cells. Additionally, we describe comprehensive preclinical readouts and guidelines for critical endpoint sample collections. In line with clinical trial procedures, our protocol broadens available treatment modalities for direct clinical translation. For complete details on the use and execution of this protocol, please refer to Donovan et al …

Esr1 And P53 Interactome Alteration Defines Mechanisms Of Tamoxifen Response In Luminal Breast Cancer, Adrianne Groman, Stephen B Edge, Carl D Morrison, Wendy M Swetzig, Jianmin Wang, Jun Hyoung Park, Benny Abraham Kaipparettu, Prashant K Singh, Shicha Kumar, Helen H Cappuccino, Manish Ranjan, Araba Adjei, Mohammad Ghasemi, Andrew K L Goey, Swati Kulkarni, Gokul M Das

Faculty, Staff and Students Publications

The canonical mechanism behind tamoxifen's therapeutic effect on estrogen receptor α/ESR1+ breast cancers is inhibition of ESR1-dependent estrogen signaling. Although ESR1+ tumors expressing wild-type p53 were reported to be more responsive to tamoxifen (Tam) therapy, p53 has not been factored into choice of this therapy and the mechanism underlying the role of p53 in Tam response remains unclear. In a window-of-opportunity trial on patients with newly diagnosed stage I-III ESR1+/HER2/wild-type p53 breast cancer who were randomized to arms with or without Tam prior to surgery, we reveal that the ESR1-p53 interaction in tumors was inhibited by Tam. This resulted in …

Comprehensive Single-Cell Atlas Of The Mouse Retina, Justin Ma, Shahil Pema, Joshua R Sanes, Graeme Mardon, Benjamin J Frankfort, Nicholas M Tran, Yumei Li, Rui Chen

Faculty, Staff and Students Publications

Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cellular heterogeneity by characterizing cell types across tissues and species. While several mouse retinal scRNA-seq datasets exist, each dataset is either limited in cell numbers or focused on specific cell classes, thereby hindering comprehensive gene expression analysis across all retina types. To fill the gap, we generated the largest retinal scRNA-seq dataset to date, comprising approximately 190,000 single cells from C57BL/6J mouse retinas, enriched for rare population cells via antibody-based magnetic cell sorting. Integrating this dataset with public datasets, we constructed the Mouse Retina Cell Atlas (MRCA) for wild-type mice, encompassing …

Protocol For Optical, Aqueous-Based Clearing Of Murine Tissues Using Ez Clear, Mary E Dickinson, Chih-Wei Hsu, Joshua D Wythe

Faculty, Staff and Students Publications

Tissue clearing is an essential prerequisite for 3D volumetric imaging of larger tissues or organs. Here, we present a detailed protocol for optical, aqueous-based clearing of adult murine tissues using EZ Clear. We describe steps to ensure successful perfusion and fixation of organs from the adult mouse and supply guidelines for optimal lipid removal, refractive index matching, and tissue clearing. Finally, we provide imaging parameters for visualizing both exogenous perfused fluorescent dyes and endogenous fluorescence reporters in the adult mouse. For complete details on the use and execution of this protocol, please refer to Hsu et al.

Timely Access To Mental Health Care Within The Veterans Affairs Healthcare System, Irene Perez Cisneros

Walden Dissertations and Doctoral Studies

Background: The Veterans Health Administration is America’s largest integrated healthcare system, providing care at 1,298 healthcare facilities, including 171 medical centers such as Michael E. DeBakey Department of Veterans Affairs Medical Center in Houston, Texas, and 1,113 outpatient healthcare clinics. Studies show that suicide rates are significantly higher among the veteran population than the general population. Purpose: The purpose of conducting a literature review is to identify factors contributing to the lack of timely access to mental health care services internally and externally. It also explored what initiatives need to be implemented to improve the timely access of mental health …

The Relationship Between Abusive Management And Counterproductive Employee Behavior In The United States, Norma Ivette Rosado

Walden Dissertations and Doctoral Studies

Abusive supervision is a kind of destructive leadership that has a detrimental influence on direct subordinates, teams, and the whole business, and counterproductive work behavior has been a critical worry for researchers and managers over the last three decades. It results in undesirable reactions, including workplace deviance, damaging attitudes, and unproductive work habits. Toxic leadership and followership are still relatively new areas of study within the broader field of leadership studies. This study aimed to determine the effects of abusive management on personnel and the business. With counterproductive work behavior (CWB) becoming an increasingly prevalent concept in the workplace, the …

Differences In Art And Music High School Students’ Sat Test Scores From 2006 To 2015, Margaret Ellen Beyer

Walden Dissertations and Doctoral Studies

Academia and education advocates have reported a concern about the elimination of art and music education classes from high school curriculums in the United States. Studies using mean SAT test scores from 1984 and 1994 versions of the SAT test indicated participants who had art and music education classes had higher verbal and mathematical SAT test scores compared to those who did not. However, since revision of the SAT test in 2005, whether students had significantly increased mean SAT test scores with each added year of art and music education participation, and whether students who participated in art and music …

A Case Study Of Layered Border Security And Traffic Problems At Laredo, Texas Port Of Entry, Christopher S. Castacio

Walden Dissertations and Doctoral Studies

Securing the border is the United States Government's top priority to keep terrorists, illegal weapons, nuclear weapons, human smuggling, and drug smuggling from entering the United States during the continuous crossing of legitimate international trades and legitimate travelers. The primary purpose of this qualitative research study was to examine layered U.S. border security and analyze the vehicle and pedestrian flow of traffic problems in Laredo, Texas, Port of Entry. Qualitative methodology was used in this study using seven interviews and open-ended questionnaires. This study's theories were the environment criminology theory, which explored and analyzed the criminal act's environment; and the …

The Association Between Mental Health And Fibromyalgia In African Americans, Shalika J. Tisinger

Walden Dissertations and Doctoral Studies

Depression and fibromyalgia can often exacerbate each other and are known to be bidirectional disorders. Chronic pain from fibromyalgia often leads to depression, and depression can cause pain to become worse and affect the nervous system, causing pain. The purpose of this quantitative, binary logistic regression study is to determine if there is an association between mental health and fibromyalgia in African Americans while controlling for cardiovascular disease, chronic kidney disease, arthritis, education level (ie. Some high school, high school graduate, some college or higher), diet, poverty-income-ratio, PIR, diabetes, gender, and age. The socio-ecological model included in this cross-sectional study …

Rotational Rheometry Test Of Portland Cement-Based Materials – A Systematic Literature Review, Laura Silvestro, Artur Spat Ruviaro, Geannina Lima, Luís Urbano Durlo Tambara Júnior, Dimitri Feys, Ana Paula Kirchheim

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This Study Systematically Reviews 62 Papers on the Use of Rotational Rheometry to Assess the Fresh State Behavior of Portland Cement-Based Materials. the Research Highlights the Wide Variation in Test Methods and Aims to Provide a Comprehensive overview. Findings Reveal that 50.0% of Studies Employed Vane Geometry, despite its Limitations in Providing Transformation Equations. Regarding Dynamic Shearing Tests, 67.0% Followed a Consensus using a Pre-Shearing Step and a Stepwise Routine with Stabilization Times ≥ 10 S. While the Bingham Model is Commonly Used, the Study Emphasizes the Importance of Considering Shear-Thinning Behavior in Cementitious Materials. Models Like Herschel-Bulkley and Modified …