Digital Commons Network^™

Folate Metabolism And Risk Of Childhood Acute Lymphoblastic Leukemia: A Genetic Pathway Analysis From The Childhood Cancer And Leukemia International Consortium, Catherine Metayer, Logan G Spector, Michael E Scheurer, Soyoung Jeon, Rodney J Scott, Masatoshi Takagi, Jacqueline Clavel, Atsushi Manabe, Xiaomei Ma, Elleni M Hailu, Philip J Lupo, Kevin Y Urayama, Audrey Bonaventure, Motohiro Kato, Aline Meirhaeghe, Charleston W K Chiang, Libby M Morimoto, Joseph L Wiemels

Faculty, Staff and Students Publications

BACKGROUND: Prenatal folate supplementation has been consistently associated with a reduced risk of childhood acute lymphoblastic leukemia (ALL). Previous germline genetic studies examining the one carbon (folate) metabolism pathway were limited in sample size, scope, and population diversity and led to inconclusive results.

METHODS: We evaluated whether ∼2,900 single-nucleotide polymorphisms (SNP) within 46 candidate genes involved in the folate metabolism pathway influence the risk of childhood ALL, using genome-wide data from nine case-control studies in the Childhood Cancer and Leukemia International Consortium (n = 9,058 cases including 4,510 children of European ancestry, 3,018 Latinx, and 1,406 Asians, and 92,364 controls). …

Human Papillomavirus Vaccination And Human Papillomavirus-Related Cancer Rates, Victor Adekanmbi, Itunu Sokale, Fangjian Guo, Jessica Ngo, Thao N Hoang, Christine D Hsu, Abiodun Oluyomi, Abbey B Berenson

Faculty, Staff and Students Publications

IMPORTANCE: To inform the design and implementation of targeted interventions to reduce the future burden of human papillomavirus (HPV)-related cancers in Texas, it is necessary to examine the county and health service region (HSR) levels of (1) the proportion of children and teenagers aged 9 to 17 years who initiated and were up to date for HPV vaccination series and (2) HPV-related cancer incidence rates (IRs).

OBJECTIVE: To evaluate temporal trends and geospatial patterns of HPV vaccination initiation and up-to-date status as well as HPV-related cancer rates at county and HSR levels in Texas.

DESIGN, SETTING, AND PARTICIPANTS: This population-based …

Keratin 17 Is A Prognostic And Predictive Biomarker In Pancreatic Ductal Adenocarcinoma, Lyanne Delgado-Coka, Lucia Roa-Peña, Sruthi Babu, Michael Horowitz, Emanuel Petricoin, Lynn Matrisian, Edik Blais, Natalia Marchenko, Felicia Allard, Ali Akalin, Wei Jiang, Md, Phd, Brent Larson, Andrew Hendifar, Vincent Picozzi, Minsig Choi, Kenneth Shroyer, Luisa Escobar-Hoyos

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

OBJECTIVES: To determine the role of keratin 17 (K17) as a predictive biomarker for response to chemotherapy by defining thresholds of K17 expression based on immunohistochemical tests that could be used to optimize therapeutic intervention for patients with pancreatic ductal adenocarcinoma (PDAC).

METHODS: We profiled K17 expression, a hallmark of the basal molecular subtype of PDAC, by immunohistochemistry in 2 cohorts of formalin-fixed, paraffin-embedded PDACs (n = 305). We determined a K17 threshold of expression to optimize prognostic stratification according to the lowest Akaike information criterion and explored the potential relationship between K17 and chemoresistance by multivariate predictive analyses.

RESULTS: …

Concurrent Ependymal And Ganglionic Differentiation In A Subset Of Supratentorial Neuroepithelial Tumors With Ewsr1-Plagl1 Rearrangement, Julieann C Lee, Sonika Dahiya, Kaleigh Roberts, Et Al.

2020-Current year OA Pubs

Neuroepithelial tumors with fusion of PLAGL1 or amplification of PLAGL1/PLAGL2 have recently been described often with ependymoma-like or embryonal histology respectively. To further evaluate emerging entities with PLAG-family genetic alterations, the histologic, molecular, clinical, and imaging features are described for 8 clinical cases encountered at St. Jude (EWSR1-PLAGL1 fusion n = 6; PLAGL1 amplification n = 1; PLAGL2 amplification n = 1). A histologic feature observed on initial resection in a subset (4/6) of supratentorial neuroepithelial tumors with EWSR1-PLAGL1 rearrangement was the presence of concurrent ependymal and ganglionic differentiation. This ranged from prominent clusters of ganglion cells within ependymoma/subependymoma-like areas, …

State Legislature Approves, Funds New Um Cannabis Program, Natalie Ehrhardt

University of Mississippi News

OXFORD, Miss. – In a significant move toward advancing medical research and patient care in Mississippi, Gov. Tate Reeves has signed a bill that establishes the Mississippi Medical Cannabis Research Program at the University of Mississippi.

The Politics Of The Commons In Post-New Order Bali, Gede Indra Pramana

Jurnal Wacana Politik

This research describes the governance practices of the commons in Bali, including land, water sources, coastal areas, and forests, which are communally owned and managed. The relationship between the state and the community has led to changes in this governance. The author examines the practice of governing the commons in the context of post-New Order Bali, offering an alternative to dominant governance that often overlooks the common welfare. This is a qualitative study that utilizes a case study method to explore alternative governance of the commons in Bali. The study examines the governance of the commons in Tenganan Pegringsingan and …

Developing The Local Political Space For Inclusive Nagari Pasia Laweh Institutions In West Sumatera, Tengku Rika Valentina, Roni Ekha Putera

Jurnal Wacana Politik

This study focuses on the local political sphere by examining the policies and the spread of Nagari’s institutional structure in West Sumatra by following Law No. 6 of 2014 about Villages. We examine and reassess the new variations of the local political sphere, focusing on local elites (Penghulu-Alim Ulama) and local communities’ growth within Nagari institutions in West Sumatra. Data was gathered via a focus group discussion (FGD) including stakeholders, regency administration, the Nagari government, and the communities. The findings are Nagari Pasia Laweh envisions an advanced Nagari based on local wisdom and open dialogue. It possesses benefits that effectively …

Documenting The “So What?” Of Evidence-Based Programs: Communicating Results To Stakeholders With Research-Based Visual Tools, Deirdre J. Avery, Kara Haberstock Tanoue, Michele E. Walsh

Journal of Extension

As part of developing the University of Arizona Cooperative Extension 4-H Common Measures system, we created resources for communicating results to stakeholders with research-based visual tools. We outline the creation of two tools that may be useful to CE personnel to use evaluation findings to better “tell their story” to a variety of stakeholders. Effectively telling this story often means addressing the question “so what?”. These tools, 1) Outcome Linkages and 2) Infographics can translate the program’s “so what?” in easily interpretable and visually engaging ways. Step by step processes are reviewed to guide creation and use of both tools.

Hospital-Associated Functional Status Decline In Pulmonary Patients, Amy C. Shay

Dissertations

Chronic obstructive pulmonary disease (COPD) is a significant worldwide cause of chronic illness and mortality and one of the most common admitting diagnoses in the United States. Persons with COPD are at increased risk for deconditioning during hospitalization, which can lead to decreased functional status at discharge. Disease-related factors and elements of the hospital environment make older adults with COPD vulnerable to hospital-associated functional status decline. The purpose of this dissertation was to identify activity factors that contribute to hospital-associated functional status decline in older adults with COPD by promoting functioning during hospitalization. This predictive correlational study is a secondary …

Ocean Properties Llc V. Sierra

All Decisions

The landlord initiated a holdover proceeding against the tenant, claiming that the tenant's license to occupy the apartment had terminated upon the death of the tenant of record. The tenant defended the proceeding by asserting that she was entitled to succeed to the tenancy pursuant to the Rent Stabilization Code. The court denied the landlord's motion for partial summary judgment, finding that the tenant's right to succeed to the tenancy was not extinguished by the terms of a prior stipulation and was protected by the Rent Stabilization Law and Code.

Appeals Court Rejects Challenge To Provision Exempting Religious Schools From Title Ix, Arthur S. Leonard

Other Publications

No abstract provided.

Table Of Contents Vol 9(1), September 2024

The International Journal of Ecopsychology (IJE)

No abstract provided.

Book Review: The Evolved Nest: Nature’S Way Of Raising Children And Creating Connected Communities

The International Journal of Ecopsychology (IJE)

No abstract provided.

An Ecopsychological Reading Of Susan Fennimore Cooper’S “Rural Hours”

The International Journal of Ecopsychology (IJE)

Ecopsychology explores the relationships between the mind (psyche) and the surrounding environment. As Andy Fisher puts it in Radical Ecopsychology (2013), ecopsychology, “would approach the psyche in relation to its earthly or natural home, its native abode” as well as the “the basic shifts in our patterns of identity and relationship that occur when we include our connection to the web of life around us as essential to human well-being.” Fisher considers ecopsychology as a project that paves the ground for changing the role of humans from exploiters to members in the biotic community. If eco or ‘oikos’ refers to …

Humanitarian Natural Disaster Response And Recovery: A Proposed Ecopsychological Framework, Megan Scott

The International Journal of Ecopsychology (IJE)

This paper explores humanitarian natural disaster response and recovery through an ecopsychological lens. The author proposes an ecopsychological approach to humanitarian natural disaster response and recovery to (that?) addresses structural and personnel challenges typical of mainstream humanitarian disaster response. Three main threads inform this proposed ecopsychological natural disaster framework. First, exploreing the roots of colonization in disaster contexts and offering different ways of knowing through Indigenous perspectives and traditional ecological knowledge. Second, examineing grief experienced by humanitarian workers. Third, offering ecopsychological tools and healing modalities to support healing and resiliency for humanitarian workers and communities on the frontlines of natural …

Artist Interview: Viken Peltekian

The International Journal of Ecopsychology (IJE)

No abstract provided.

Vol 9(1) Editorial: Dr. Matthew Jamnik, Matthew Jamnik

The International Journal of Ecopsychology (IJE)

No abstract provided.

Ecopoetry As Mind Into Matter: Some Educational Possibilities

The International Journal of Ecopsychology (IJE)

In part, this work draws on the revisioning of curriculum in the context of the climate crisis that occupies Chapter 8 of the author’s book on Sense of Place, Identity, and the Revisioning of Curriculum (2023: Springer Nature). The focus here is the “genre” of ecopoetry, described by Walton (2018) as “contributing to the task of repairing divisions between humanity and the ecosystems that constitute and support us” (p. 393). As a response to the Anthropocene, ecopoetry is potentially polemical and activist. However, as it is argued, it can also operate in more covert means by modelling ways in which …

Americanitis

The International Journal of Ecopsychology (IJE)

No abstract provided.

The Relationship Between The Physical Activity Environment, Nature Relatedness, Anxiety, And The Psychological Well-Being Benefits Of Regular Exercisers

The International Journal of Ecopsychology (IJE)

Research from a variety of scientific fields suggests that physical activity in nature and feelings of connection to nature enhance psychological health and well-being. This study investigated the psychological health and well-being impact of the physical activity environment for those already undertaking the recommended weekly amount of physical activity. This topic is important for the design of health and well-being environments and interventions involving physical activity. Participants (N = 262) aged 18–71 years (M = 34.5, SD = 13.1) who met the UK physical activity guidelines completed the Nature Relatedness Scale, the trait section of the State Trait Inventory for …

Good Newsletter September 03, 2024, Seattle University School Of Law Dean

GOOD NEWSletter

No abstract provided.

Student Life E-Newsletter September 03, 2024, Seattle University School Of Law Student Life

Student Life E-Newsletters

No abstract provided.

~Common Sounds~ By Adam Wither

The International Journal of Ecopsychology (IJE)

"[...] The pond-bowl yearns, afterwards, in gentle dying ripples mist swirling the morning sun heavy barely rising. [...]"

American Letters: Theodore Dreiser (1871-1945), Editorial Board

The International Journal of Ecopsychology (IJE)

“Life seems to prove but one thing to me, and that is that the various statements concerning right, truth, justice, mercy are palaver merely, an earnest and necessitous attempt, perhaps, at balance and equation where all things are so very much unbalanced, paradoxical and contradictory—the small-change names for a thing or things of which we have not yet caught the meaning. History teaches me little save that nothing is really dependable or assured, but all inexplicable and all shot through with a great desire on the part of many to do or say something by which they may escape the …

Undergraduate Degree Type And Passing The Registered Dietitian Nutritionist Exam On The First Attempt, Jennifer J. Ford

Walden Dissertations and Doctoral Studies

To meet accreditation benchmarks, program directors of dietetic education programs monitor registered dietitian nutritionist (RDN) exam pass rates. The RDN exam first-time pass rate for a midwestern university’s dietetic coordinated graduate program (CGP) had been 72.73% in 2022, 47.62% in 2021, 60.87% in 2020, and 69.7% in 2019, all of which fell below the required minimum of 80% for accredited dietetic education programs. The purpose of this study was to explore the association between undergraduate degree type and passing the RDN exam on the first attempt. Constructivism was the theoretical framework that informed this study. This study employed a quantitative …

2024 September 3 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Flavonoid-Rich Foods, Dementia Risk, And Interactions With Genetic Risk, Hypertension, And Depression, Amy Jennings, Alysha S. Thompson, Anna Tresserra-Rimbau, Joshua K. O'Neill, Claire Hill, Nicola P. Bondonno, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Importance: A composite score of flavonoid-rich foods (flavodiet) may provide a clear public health message regarding the range of foods with the potential to lower dementia risk. Objective: To examine associations of flavodiet score and intakes of flavonoid subclasses with dementia risk according to genetic risk and presence of depression and hypertension. Design, Setting, and Participants: This prospective, population-based cohort study included dietary data from adults aged 40 to 70 years in the UK Biobank, recruited between 2006 and 2010, with a mean (SD) follow-up of 9.2 (1.5) years. The data analyses were conducted from September 1 to 30, 2023. …

Residual Stroke Risk Among Patients With Atrial Fibrillation Prescribed Oral Anticoagulants: A Patient-Level Meta-Analysis From Combine Af, Linda Johnson, Alexander Benz, Ashkan Shoamanesh, John W Eikelboom, Michael Ezekowitz, Robert Giugliano, Lars Wallentin, Christian Ruff, Renato Lopes, Sanjit Jolly, Richard Whitlock, Christopher Granger, Stuart Connolly, Jeffrey Healey

Division of Cardiology Faculty Papers

Background: Despite oral anticoagulation, patients with atrial fibrillation (AF) remain at risk of ischemic stroke and systemic embolism (SE) events. For patients whose residual risk is sufficiently high, additional therapies might be useful to mitigate stroke risk.

Methods and results: Individual patient data from 5 landmark trials testing oral anticoagulation in AF were pooled in A Collaboration Between Multiple Institutions to Better Investigate Non-Vitamin K Antagonist Oral Anticoagulant Use in AF (COMBINE AF). We calculated the rate of ischemic stroke/SE among oral anticoagulation-treated patients with a CHA₂DS₂-VASc score≥2, across strata of CHA₂DS₂-VASc …

Segregation By Payer In Obstetrics And Gynecology Residency Ambulatory Care Sites, Kavita Vinekar, Neena Qasba, Hannah Reiser, Erika Banks, Kavita Arora, Brownsyne Edmonds, Karen George

Department of Obstetrics and Gynecology Faculty Papers

IMPORTANCE: Many teaching hospitals in the US segregate patients by insurance status, with resident clinics primarily composed of publicly insured or uninsured patients and faculty practices seeing privately insured patients. The prevalence of this model in obstetrics and gynecology residencies is unknown.

OBJECTIVES: To examine the prevalence of payer-based segregation in obstetrics and gynecology residency ambulatory care sites nationally and to compare residents' and program directors' perceptions of differences in quality of care between payer-segregated and integrated sites.

DESIGN, SETTING, AND PARTICIPANTS: This national survey study included all 6060 obstetrics and gynecology residents and 293 obstetrics and gynecology residency program …

Tomivosertib Reduces Ectopic Activity In Dorsal Root Ganglion Neurons From Patients With Radiculopathy, Yan Li, Megan L Uhelski, Robert Y North, Juliet M Mwirigi, Claudio E Tatsui, Kathleen E Mcdonough, Juan P Cata, German Corrales, Greg Dussor, Theodore J Price, Patrick M Dougherty

Faculty, Staff and Student Publications

Spontaneous activity in dorsal root ganglion (DRG) neurons is a key driver of neuropathic pain in patients suffering from this largely untreated disease. While many intracellular signalling mechanisms have been examined in preclinical models that drive spontaneous activity, none have been tested directly on spontaneously active human nociceptors.

Using cultured DRG neurons recovered during thoracic vertebrectomy surgeries, we showed that inhibition of mitogen-activated protein kinase interacting kinase (MNK) with tomivosertib (eFT508, 25 nM) reversibly suppresses spontaneous activity in human sensory neurons that are likely nociceptors based on size and action potential characteristics associated with painful dermatomes within minutes of treatment. …