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Articles 323581 - 323610 of 5154137
Full-Text Articles in Entire DC Network
The Future Of Robotic-Teacher Relationship In Classrooms: Cooperation Or Competition?, Miaad Saleh Hassan Abdullah Mobarak
The Future Of Robotic-Teacher Relationship In Classrooms: Cooperation Or Competition?, Miaad Saleh Hassan Abdullah Mobarak
Theses
As the realms of artificial intelligence (AI) and robotics undergo exponential growth and the issue of teacher shortage remains a concern, the potential for remarkable advancements in education with the assistance of robots becomes increasingly important. This review is conducted to understand the forthcoming role of robotics in education and its impact on teachers’ role in the classroom. Currently, it is widely known that AI is evolving in a rapid way, creating a huge presence in our life, building a perception among people that it will take over the role of human in various settings in the future. Various articles …
Integration Of Blockchain And Machine Learning For Robust Intrusion Detection In Iot Network, Saeed Al Banna
Integration Of Blockchain And Machine Learning For Robust Intrusion Detection In Iot Network, Saeed Al Banna
Theses
This thesis explores the integration of blockchain technology and machine learning techniques to enhance cybersecurity in IoT networks. An intrusion detection system (IDS) framework is proposed, leveraging the decentralized, immutable, and transparent features of blockchain with the predictive capabilities of machine learning. The study utilizes the CICIoT2023 dataset, which has 33 diverse attack types on 105 devices, to evaluate five machine learning models: Random Forest, MLP, CNN, and RNN and a Hybrid RF/MLP Model. The Random Forest and MLP models demonstrated superior performance across multi-class, grouped, and binary classification tasks. Blockchain technology is integrated to securely log detected anomalies, to …
Developing Coexpression Systems To Introduce Hydroxyproline Into Protein Engineered Collagen Peptides Utilizing Hydroxylase From Acanthamoeba Polyphaga Mimivirus, Jennifer Soldatich
Developing Coexpression Systems To Introduce Hydroxyproline Into Protein Engineered Collagen Peptides Utilizing Hydroxylase From Acanthamoeba Polyphaga Mimivirus, Jennifer Soldatich
Theses and Dissertations
A major challenge of developing collagen mimetic peptides (CMPs) by bacterial expression is to include hydroxyproline for biomedical applications. Coexpression of Prolyl-4-hydroxylase from A.mimivirus with CMPs was investigated. Additionally, four expression designs were created for potential applications in mammalian cells to utilize their natural ability of proline-hydroxylation by post-translational modification.
Virtual Reality: Communication Channels, Trust, And Board Oversight, Nicola Faith Sharpe
Virtual Reality: Communication Channels, Trust, And Board Oversight, Nicola Faith Sharpe
The Business, Entrepreneurship & Tax Law Review
Post-pandemic, corporate directors, executives, and other employees are frequently found working from home as part of the modern global remote workforce. Since 2020’s pandemic necessitated mass exodus from the in-person workplace, working remotely has become the default for many. Quite the opposite of a transient phenomenon or a global pandemic stopgap measure, remote work is here to stay. It has changed more than the location of where business is conducted. It shifted the primary professional communication medium from face to face communications to virtual, computer mediated communications.
Insurance Law And Religious Belief, Chad Marzen
Insurance Law And Religious Belief, Chad Marzen
The Business, Entrepreneurship & Tax Law Review
This Article adds to the corpus of academic scholarship in insurance law with an analysis of jurisprudence involving insurance law and religious belief. Outside of the issue of contraception, health insurance and religious exemptions, there are a number of areas where insurance law intersects with religious belief. These areas, examined in this Article, include the admissibility of testimony regarding religious beliefs in liability cases, unemployment compensation and religious belief, the relationship between worker's compensation and religious belief, and whether motor vehicle financial responsibility laws violate the First Amendment.
Vol. 67, No. 02 (September 2, 2024)
Discovering How Exceptional Female Native Americans In Contemporary Educational Contexts Form Sustained Motivation, Vellena V. Howard
Discovering How Exceptional Female Native Americans In Contemporary Educational Contexts Form Sustained Motivation, Vellena V. Howard
Doctor of Education (EdD)
This phenomenological study embarked on a journey with four Native American females to discover the lifelong and life-wide experiences that led to sustained motivation as evidenced through their extended careers in contemporary educational settings. Limited research exists on Native American-voiced perceptions surrounding issues pertinent to their success. A series of three life interviews afforded meaning-making of key moments, from earliest to current. A Two- Eyed Seeing approach centering Indigenous and Western knowledge systems viewed Indigenous motivation holistically through The First Nations Holistic Lifelong Learning Model, the study’s guiding framework. Influencing elements included teachers, mentors, experiential learning, and learning from self-revelation, …
Impact Of A Suicide Prevention Learning Module For Firearm Training Courses In Louisiana, Claire Houtsma, Lauren Reyes, Katherine Macwilliams, Gala True
Impact Of A Suicide Prevention Learning Module For Firearm Training Courses In Louisiana, Claire Houtsma, Lauren Reyes, Katherine Macwilliams, Gala True
School of Medicine Faculty Publications
Background: Firearm suicide is a leading cause of death in the United States. Suicide prevention experts have advocated for upstream interventions that can be implemented prior to the development of suicidal thoughts, particularly those that focus on lethal means safety (LMS; e.g., increasing secure firearm storage). To reach firearm owners with LMS messaging, researchers have developed suicide prevention training content which can be incorporated into firearm training courses. However, no study to date has evaluated impact of such training on firearm course students’ subsequent knowledge, attitudes, and openness related to secure firearm storage. Thus, the current study sought to examine …
Mmu: 09/02/24–09/08/24, Student Bar Association
Mmu: 09/02/24–09/08/24, Student Bar Association
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Potential Nec2/Nek1 Inhibitor And Inh1 Analog N-[4-(2,4-Dimethylphenyl)-2-Thiazolyl]-4-Pyridinecarboxamide Via Hantzsch Thiazol Condensation, Robert E. Lee Sr, Isabella G. Mcdonald, Paige E. Heiple, Lukas D. Shelton
Potential Nec2/Nek1 Inhibitor And Inh1 Analog N-[4-(2,4-Dimethylphenyl)-2-Thiazolyl]-4-Pyridinecarboxamide Via Hantzsch Thiazol Condensation, Robert E. Lee Sr, Isabella G. Mcdonald, Paige E. Heiple, Lukas D. Shelton
Journal of the South Carolina Academy of Science
The potential active pharmaceutical ingredient (API), N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide (6) is a cancer cell metabolism mitosis inhibitor via the Nek2 and Hec1 enzymes. The three-step synthesis starts with the bromination of 1-(2,4-dimethylphenyl)ethan-1-one (1) using CuBr2 to produce 2-bromo-1-(2,4-dimethylphenyl)ethan-1-one (2) with a yield of 90%.[i],[ii],[iii] Followed by Hantzsch thiazol ring synthesis as (2) reacts with thiourea (3) and, resulting in 4-(2,4-dimethylphenyl)thiazol-2-amine (4)[iv] in 80% yield. Finally, isonicotinoyl chloride hydrochloride (5) and (4) reacted to form the amide (6).[v],[vi],[vii],[viii],[ix],[x] Characterization of the final product was determined …
Determining Drug Dosage Using Calculus, Rajendra Dahal, Keith Bullard
Determining Drug Dosage Using Calculus, Rajendra Dahal, Keith Bullard
Journal of the South Carolina Academy of Science
For most drugs, there is a concentration below for which the drug is ineffective and a concentration above for which the drug is dangerous. In this paper, we will study how the dosage and dosing intervals can be modified to ensure a safe, yet efficient level of the drug in the bloodstream using calculus. In particular, we will study the concentration of a drug over time and its dosing schedule.
Length-Weight And Length-Length Relationships For Common Fish And Invertebrate Species In The North Inlet-Winyah Bay Estuarine System, South Carolina, Usa, Catherine A. Friedline, Matthew E. Kimball, Bruce W. Pfirrmann, In Cha, Kayleigh B. Wolstenholme, Ryan J. Rezek
Length-Weight And Length-Length Relationships For Common Fish And Invertebrate Species In The North Inlet-Winyah Bay Estuarine System, South Carolina, Usa, Catherine A. Friedline, Matthew E. Kimball, Bruce W. Pfirrmann, In Cha, Kayleigh B. Wolstenholme, Ryan J. Rezek
Journal of the South Carolina Academy of Science
Establishing accurate weight-length relationships (WLR) and length-length relationships (LLR) is critical for effective fisheries management and ecological research. This study updates these essential metrics for commonly found fish and shrimp species in the North Inlet-Winyah Bay estuarine system, South Carolina, addressing gaps where previous data were unavailable, outdated, or sourced from other regions. Our research analyzed 7,874 specimens from 20 species across thirteen families, collected through trawl samples and bi-weekly seines from November 2022 to December 2023. The findings demonstrate robust WLRs with high coefficients of determination. Similarly, the LLRs confirmed reliable conversions between different length measurements. This study not …
Wild Pigs (Sus Scrofa) At Croft State Park In Spartanburg County, South Carolina, Jonathan J. Storm, Amelia R. Scollon, Melissa A. Storm, Briget C. Doyle
Wild Pigs (Sus Scrofa) At Croft State Park In Spartanburg County, South Carolina, Jonathan J. Storm, Amelia R. Scollon, Melissa A. Storm, Briget C. Doyle
Journal of the South Carolina Academy of Science
No abstract provided.
Examination Of Oncogenic Effects Of Environmental Pollutants, Andrew Ackerman, Matthew Behling, Brock Earley, Janay Vacharasin
Examination Of Oncogenic Effects Of Environmental Pollutants, Andrew Ackerman, Matthew Behling, Brock Earley, Janay Vacharasin
Journal of the South Carolina Academy of Science
Chemical byproducts produced by surrounding industrial complexes have polluted the local estuaries of Georgetown, South Carolina for several decades1. Previous studies completed by the EPA and SCDNR showed that the estuaries contained carcinogenic pollutants released from the local manufacturing plants1. One of the mentioned pollutants was dioxins which are produced during the paper bleaching process2. Dioxins are highly toxic compounds that have various carcinogenic effects on the organisms that inhabit the area. These previous studies were conducted over thirty years ago. Therefore, a current study to determine if chemical byproducts are contaminating local estuaries …
Hpv Prevalence In A College-Aged Sample Group And Its Link To Sexual Behaviors And Attitudes, Emily E. Bishop, Rahjai Thomas, Katelyn Ambrose, Gabriela Lewczyk, Paul E. Richardson
Hpv Prevalence In A College-Aged Sample Group And Its Link To Sexual Behaviors And Attitudes, Emily E. Bishop, Rahjai Thomas, Katelyn Ambrose, Gabriela Lewczyk, Paul E. Richardson
Journal of the South Carolina Academy of Science
HPV, or Human Papilloma Virus, is the most common Sexually Transmitted Infection (STI). It is the number one STI in men and women. There are over 460 subtypes; a majority of the subtypes are able to be cleared by the human immune system within 3 years after initial infection. However fifteen of these subtypes have been classified as ‘high-risk’ for carcinoma development, accounting for almost 100% of cervical cancers. This STI has an age prevalence starting at 19 for oral and genital infections. The overall goal of this research is to provide students with an equally represented and unbiased database …
A Triumph Of Conservation: The University Of South Carolina Aiken’S Bluebird Trail, Alyssa Godfrey, Emory Owens, Quinn Schreiber, Michelle L. Vieyra
A Triumph Of Conservation: The University Of South Carolina Aiken’S Bluebird Trail, Alyssa Godfrey, Emory Owens, Quinn Schreiber, Michelle L. Vieyra
Journal of the South Carolina Academy of Science
The Eastern Bluebird (Sialia sialis) was once an endangered species, with over 90% of its population declining in the early 1900s (Ritchison, 2000). These birds play a crucial role in regulating insect populations and maintaining the safety of food sources, making them important both economically and environmentally. Eastern Bluebirds are proof that conservation efforts work, as they are now a species of least conservation concern in the United States. Since 2020, undergraduate students at the University of South Carolina Aiken have collaborated with the South Carolina Bluebird Society to establish and monitor 31 nesting boxes across the main campus …
Striatal Beat Frequency Interval Timing Model With Microgravity Stressor, Jason Michael Fitzgerald, Sorinel Oprisan
Striatal Beat Frequency Interval Timing Model With Microgravity Stressor, Jason Michael Fitzgerald, Sorinel Oprisan
Journal of the South Carolina Academy of Science
The Striatal Beat Frequency (SBF) model of interval timing uses frontal cortex (FC) neural oscillations to record the state of the brain at the reinforcement time Tc during fixed interval (FI) procedures in the long-term memory (LMEM). The state of the FC oscillators at any given time is stored in a short-term memory (SMEM) buffer. The SBF model uses the spiny neurons of the basal ganglia (BG) as coincidence detectors to produce beats between the content of the SMEM and LMEM. Across multiple species that can perform interval timing, there are two invariant properties: (a) the timing is precise, and …
Growth And Mobility Of Physella Acuta Under Individual And Combined Acetaminophen And Salinity Exposure, Rhea Wilder, Jason Doll, Daniel Elias
Growth And Mobility Of Physella Acuta Under Individual And Combined Acetaminophen And Salinity Exposure, Rhea Wilder, Jason Doll, Daniel Elias
Journal of the South Carolina Academy of Science
Global climate change, driven by rapid population growth and anthropogenic activities, presents an urgent challenge to aquatic ecosystems. Salinity intrusion threatens water quality and availability for human and wildlife populations. At the same time, due to the demand for pharmaceuticals, these pollutants are increasingly detected in freshwater environments, with acetaminophen being one of the most prevalent. This research analyzed the individual and combined effects of salinity (2.5 g/L) and acetaminophen (488 μg/L) on Physella acuta. Overall, we observed reduced snail movement under elevated salinity and no effects on growth or movement with acetaminophen alone or in combination with salinity. …
Movement And Diving Behavior Of Satellite-Tagged Male Sperm Whales In The Gulf Of Alaska, Lauren A. Wild, Franz J. Mueter, Janice Straley, Russ D. Andrews
Movement And Diving Behavior Of Satellite-Tagged Male Sperm Whales In The Gulf Of Alaska, Lauren A. Wild, Franz J. Mueter, Janice Straley, Russ D. Andrews
Faculty
Male sperm whales (Physeter macrocephalus) are known to interact with and depredate from commercial longline fishing vessels targeting sablefish (Anoplopoma fimbria) in the Gulf of Alaska (GOA). This study aims to better understand their movement patterns and diving behavior in this region, and in relation to depredation behavior. Between 2007 and 2016 a total of 33 satellite tags were deployed on sperm whales interacting with fishing vessels in the eastern GOA. A subset of these tags also collected dive characteristics. We used state space models to interpolate hourly positions from tags and estimate behavioral state from 29 usable tag records, …
Methods For Efficient Computation Of Neutron Multiplicity Distributions And Snm Sample Characterization, Jawad Ribhi Moussa
Methods For Efficient Computation Of Neutron Multiplicity Distributions And Snm Sample Characterization, Jawad Ribhi Moussa
Nuclear Engineering ETDs
This dissertation advances neutron multiplicity counting (NMC) by developing a hierarchy of computational methods that combine deterministic and stochastic techniques with modern machine learning for improved special nuclear material (SNM) characterization. A system state-updating Monte Carlo method is introduced in addition to a dynamic point kinetic model based on a backward Master equation (BME) formulation. These models, along with newly developed distribution reconstruction methods, enable more efficient computation of neutron count distributions in a fixed detector time-gate. NMC limitations associated with finite-size and neutron phase effects are also addressed by extending the BME model to account for time-gated neutron count …
Nitrogen Credits After Peanut (Arachis Hypogaea L.), Michael J. Mulvaney, Joseph E. Iboyi, Kipling S. Balkcom, David Jordan, Brendan Zurweller, Arun Jani
Nitrogen Credits After Peanut (Arachis Hypogaea L.), Michael J. Mulvaney, Joseph E. Iboyi, Kipling S. Balkcom, David Jordan, Brendan Zurweller, Arun Jani
Biology, Agriculture and Chemistry Faculty Publications and Presentations
State-level cooperative extension services provide fertilizer recommendations for row crops in the United States. Of these, nitrogen (N) recommendations are arguably the most important because N is the most common yield-limiting nutrient in nonlegume crop production systems. Throughout the peanut (Arachis hypogaea L.) growing region of the United States, Cooperative Extension Services generally recommends 22–67 kg N/ha credit to crops following peanut, likely due to the assumption that peanut, being a legume, contributes N to the following crop. The body of peer-reviewed literature indicates that N credits from peanut to the subsequent crop are negligible. Recent literature indicates that …
“Home Is The Mouth Of A Shark”: Trauma And The Needs Of Students From Refugee Backgrounds From The Perspective Of Boundary Spanning Refugee Resettlement Workers, Shyla González-Doğan, Gonca Soyer, Siddika Asik Bayhan, Mualla Yazici, Meryem Akçay, Jordan Harb, Awad Mekkawi Ramadan, Adnan Turan
“Home Is The Mouth Of A Shark”: Trauma And The Needs Of Students From Refugee Backgrounds From The Perspective Of Boundary Spanning Refugee Resettlement Workers, Shyla González-Doğan, Gonca Soyer, Siddika Asik Bayhan, Mualla Yazici, Meryem Akçay, Jordan Harb, Awad Mekkawi Ramadan, Adnan Turan
Montclair State University Scholarship & Creative Works
This research project examines the experiences of four individuals working in refugee resettlement and their perspectives on the educational needs of refugee students, given their role as boundary spanners. They also discuss the need for teachers to encourage students to use the Funds of Knowledge in the classroom. Participants discuss their varied experience as professionals in refugee resettlement, with two being refugees and one being an immigrant. This paper (1) explores the stress associated with relocation, (2) delves into the mental health issues faced by individuals from refugee backgrounds, emphasizing trauma, (3) analyzes how inefficiencies and lack of support within …
Efficacy And Safety Of Blood Flow Restriction Therapy In Knee Arthroplasty, Zayd M. Ayas, Michael Sander
Efficacy And Safety Of Blood Flow Restriction Therapy In Knee Arthroplasty, Zayd M. Ayas, Michael Sander
MEDI 9331 Scholarly Activities Clinical Years
Blood Flow Restriction (BFR) treatment is gaining attention as a method for improving recovery and muscle strength following total knee replacement surgery (TKA). This analysis combines results from studies to assess how effective and safe BFR therapy is, in postoperative settings and to highlight any possible drawbacks it may have. Studies suggest that when administered correctly BFR therapy can bring advantages to patients in terms of their recovery process, muscle strength improvement and overall health status. Several research investigations indicate that Blood Flow Restriction (BFR) therapy plays a role in enhancing post-surgery results for individuals with severe post operative muscle …
Emergent Medication Labels In The Pediatric Intensive Care Unit, Christine Hajovsky
Emergent Medication Labels In The Pediatric Intensive Care Unit, Christine Hajovsky
EBP Fellowship
No abstract provided.
Exploring Ai Technology And Consumer Behavior In Retail Interactions, Maria Petrescu, Anjala S. Krishen, John T. Gironda, J. Ricky Fergurson
Exploring Ai Technology And Consumer Behavior In Retail Interactions, Maria Petrescu, Anjala S. Krishen, John T. Gironda, J. Ricky Fergurson
Publications
This research systematically reviews artificial intelligence (AI) effects in customer-interfacing retail applications based on an ecosystem value co-creation framework. We conduct a bibliometric and conceptual mapping analysis study, focusing on AI-related implications for consumers’ and other stakeholders' well-being, social interaction, and societal welfare. A co-citation network visualization of critical AI journal articles is generated, and a network visualization of AI keyword relationships and clustered topic areas is presented and discussed, along with a conceptual map of the relationships between key concepts and substantive AI themes. In an ecosystem context, the multidisciplinary-based bibliometric and conceptual mapping findings of our analysis reflect …
Enhanced External Counterpulsation Improves Dyspnea, Fatigue, And Functional Capacity In Patients With Long Covid, Jessie Fox, Farhan Ali, Marielisa Lopez, Sachin A. Shah, Christian W. Schmidt, Odayme Quesada, Timothy D. Henry, Monica Verduzco-Gutierrez
Enhanced External Counterpulsation Improves Dyspnea, Fatigue, And Functional Capacity In Patients With Long Covid, Jessie Fox, Farhan Ali, Marielisa Lopez, Sachin A. Shah, Christian W. Schmidt, Odayme Quesada, Timothy D. Henry, Monica Verduzco-Gutierrez
Pacific Faculty Work
Approximately 31% of patients previously infected with SARS-CoV-2 are living with symptoms of long COVID in the United States. Long COVID significantly reduces quality of life and increases morbidity and disability; however, treatment options are limited. Enhanced External Counterpulsation (EECP) is an FDA-approved, non-invasive treatment for the management of cardiovascular symptoms with a mechanism of action which stimulates pathways that induce endothelial homeostasis, improving microvascular function, inflammation, and immune regulation, thereby potentially targeting the underlying etiology of long COVID. We recently reported that EECP improved symptoms in 231 patients with long COVID. Previous studies assessing the effects of EECP for …
Sourcing Derivatives: Time To Reverse The Rule?, Reuven S. Avi-Yonah
Sourcing Derivatives: Time To Reverse The Rule?, Reuven S. Avi-Yonah
Articles
In their excellent Tax Notes article on the application of withholding taxes on derivatives, Lorenz F. Haselberger and Michael B. Shulman write that:
A taxpayer entering into a derivative may derive income of a kind that is different from the kind of income that would have been realized had the taxpayer instead acquired the underlying asset, resulting in different U.S. withholding tax treatment.
For example, when a foreign taxpayer enters into a swap referencing an equity security or interest rate, amounts it receives that correspond to dividends or interest generally are characterized as periodic payments on a financial contract rather …
Microrna-532-3p Modulates Colorectal Cancer Cell Proliferation And Invasion Via Suppression Of Foxm1, Ketakee Mahajan, Ani V. Das, Suresh K. Alahari, Ramesh Pothuraju, S. Asha Nair
Microrna-532-3p Modulates Colorectal Cancer Cell Proliferation And Invasion Via Suppression Of Foxm1, Ketakee Mahajan, Ani V. Das, Suresh K. Alahari, Ramesh Pothuraju, S. Asha Nair
School of Graduate Studies Faculty Publications
Colorectal cancer (CRC) is a heterogeneous disease and classified into various subtypes, among which transcriptional alterations result in CRC progression, metastasis, and drug resistance. Forkhead-box M1 (FOXM1) is a proliferation-associated transcription factor which is overexpressed in CRC and the mechanisms of FOXM1 regulation have been under investigation. Previously, we showed that FOXM1 binds to promoters of certain microRNAs. Database mining led to several microRNAs that might interact with FOXM1 3’UTR. The interactions between shortlisted microRNAs and FOXM1 3’UTR were quantitated by a dual-luciferase reporter assay. MicroRNA-532-3p interacted with the 3’UTR of the FOXM1 mRNA transcript most efficiently. MicroRNA-532-3p was ectopically …
Optimizing Tigertriever Adjustable Stentriever Technique: Operators’ Experience, Brian Jankowitz, Eitan Abergel, Ronit Agid, Abdul Rahman Al-Schameri, Krzysztof Bartosz Kądziołka, Allan Brook, Michael Diepers, Jeffrey Farkas, Johanna Fifi, Sebastian Fischer, Chirag Gandhi, Reid Gooch, Ramesh Grandhi, Guglielmo Pero, Guy Raphaeli, Sudipta Roychowdhury, Shahram Majidi, Christian Paul Stracke, Nader Sourour, Omar Tanweer, Satoshi Tateshima, Phil Taussky, Martin Wiesmann, Albert Yoo, Daniel W Zumofen, Justin Singer
Optimizing Tigertriever Adjustable Stentriever Technique: Operators’ Experience, Brian Jankowitz, Eitan Abergel, Ronit Agid, Abdul Rahman Al-Schameri, Krzysztof Bartosz Kądziołka, Allan Brook, Michael Diepers, Jeffrey Farkas, Johanna Fifi, Sebastian Fischer, Chirag Gandhi, Reid Gooch, Ramesh Grandhi, Guglielmo Pero, Guy Raphaeli, Sudipta Roychowdhury, Shahram Majidi, Christian Paul Stracke, Nader Sourour, Omar Tanweer, Satoshi Tateshima, Phil Taussky, Martin Wiesmann, Albert Yoo, Daniel W Zumofen, Justin Singer
Faculty, Staff and Students Publications
The Tigertriever is a novel, radially adjustable stentriever that addresses limitations in traditional mechanical thrombectomy devices by providing enhanced user control over clot integration. This provides the ability to adapt to patient-specific factors such as varying vessel sizes and clot compositions and may be particularly crucial for ensuring efficacy and safety in distal locations. This consensus paper synthesizes the clinical techniques from a consortium of experienced international operators. It outlines the current data on the Tigertriever, discusses the new operator-controlled capabilities, and provides a recommended approach for both proximal and distal mechanical thrombectomy, emphasizing the "FLEX" approach (Fast Controlled Expansion …
Setrusumab For The Treatment Of Osteogenesis Imperfecta: 12-Month Results From The Phase 2b Asteroid Study, Francis H Glorieux, Bente Langdahl, Roland Chapurlat, Suzanne Jan De Beur, Vernon Reid Sutton, Kenneth E S Poole, Kathryn M Dahir, Eric S Orwoll, Bettina M Willie, Nicholas Mikolajewicz, Elizabeth Zimmermann, Seyedmahdi Hosseinitabatabaei, Michael S Ominsky, Chris Saville, James Clancy, Alastair Mackinnon, Arun Mistry, Muhammad K Javaid
Setrusumab For The Treatment Of Osteogenesis Imperfecta: 12-Month Results From The Phase 2b Asteroid Study, Francis H Glorieux, Bente Langdahl, Roland Chapurlat, Suzanne Jan De Beur, Vernon Reid Sutton, Kenneth E S Poole, Kathryn M Dahir, Eric S Orwoll, Bettina M Willie, Nicholas Mikolajewicz, Elizabeth Zimmermann, Seyedmahdi Hosseinitabatabaei, Michael S Ominsky, Chris Saville, James Clancy, Alastair Mackinnon, Arun Mistry, Muhammad K Javaid
Faculty, Staff and Students Publications
Osteogenesis imperfecta (OI) is a rare genetic disorder commonly caused by variants of the type I collagen genes COL1A1 and COL1A2. OI is associated with increased bone fragility, bone deformities, bone pain, and reduced growth. Setrusumab, a neutralizing antibody to sclerostin, increased areal bone mineral density (aBMD) in a 21-week phase 2a dose escalation study. The phase 2b Asteroid (NCT03118570) study evaluated the efficacy and safety of setrusumab in adults. Adults with a clinical diagnosis of OI type I, III, or IV, a pathogenic variant in COL1A1/A2, and a recent fragility fracture were randomized 1:1:1:1 to receive 2, 8, or …