Digital Commons Network^™

From Readiness To Transformation: The Mediating Role Of Digital Maturity In Linking Ai Readiness To Organizational Change In Hospitals, Muhammad Ryan Adi Putra, Giovanni Reynaldo, Dewi Sri Surya Wuisan

Journal of Health Research

Background: Organizational readiness is essential for AI-enabled digital transformation as healthcare organizations increasingly integrate artificial intelligence (AI). However, empirical evidence regarding the relationship between AI readiness and organizational change, the mediating role of digital maturity, remains limited in healthcare settings. This study investigated the mediating role of digital maturity in the relationship between AI readiness and organizational change.

Methods: This cross-sectional study involved 300 healthcare professionals from two Indonesian hospitals: Persahabatan Hospital (n = 165) and St. Carolus Hospital (n = 135). Data were collected using a questionnaire and analyzed through Partial Least Squares Structural Equation Modeling (PLS-SEM) to assess …

Identification Of Ca2 As A Potential Candidate Gene Involved In The Therapeutic Effect Of Huatan Huoxue Decoction On Polycystic Ovary Syndrome: An Integrated Study Of Network Pharmacology, Mendelian Randomization, And Experimental Validation, Chan Zhu, Yijin Zhang, Panwei Hu, Cong Qi, Qiu Chen, Hong Yang, Jing Li

Journal of Food and Drug Analysis

Purpose: Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Methods: Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for PCOS from the FinnGen R12 database. These targets were integrated with the active ingredients and protein targets of HTHXD retrieved from the TCMSP and BATMAN-TCM databases for network pharmacology analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted. Core targets were validated using molecular docking. Experimental validation was performed using a letrozole-induced …

Impact Of The Widespread Use Of Online Pharmacies On Overall Consumer Safety, Hasanain Am. Abbas, Eswar Kumar Kilari, Shereen M. Mekkey, Hussein Ahmed Jabbar, Mohammed Haider Majid, Haider Majeed Abd Abbas, Hassanein Khaled Hassan

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Online pharmacies improve access to medicines by offering convenient ordering and home delivery, but their growth also creates important risks for medication safety and public health. This review examines the benefits and hazards associated with online medicine supply, including access without a valid prescription, falsified and substandard products, inappropriate medicine use, privacy breaches, and weak cross-border regulatory oversight. The available evidence indicates that illicit online sellers can expose consumers to products of uncertain identity, quality, and dose, while vulnerable users may have limited ability to distinguish legitimate services from unlawful vendors. At the same time, licensed platforms can support continuity …

Preparation And In Vitro Evaluation Of Gastro-Retentive Tablets Of Frusemide Using Gas Generating Excipients As Floating Mechanism, Yousif K. Younis, Ahmed Yousif Fadhel, Nihad Hussein Ahmed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Frusemide is a loop diuretic used for hypertension, heart failure among many other indications. It has an absorption window in the stomach and it's a class IV drug according to BCS with low bioavailability.
Floating tablets are one of the dosage forms that is best suited for drugs with such absorption window and gas generating excipients can be used to reduce floating lag times even more than traditional floating tablets that relay on density difference alone.
The aim of the study was to investigate the feasibility of floating tablets as a convenient dosage form for oral administration of frusemide aiming …

Impact Of Erythropoietin Therapy On Inflammatory Biomarkers In Chronic Kidney Disease: A Comparative Study, Riyam Naji Al_Alwani, Jahanbakhsh Asadi, Zainab Mohammadi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Chronic kidney disease (CKD) is a progressive disorder frequently complicated by anemia and a persistent inflammatory state, both of which significantly contribute to morbidity and mortality. Reduced renal production of erythropoietin (EPO) is the primary cause of anemia in CKD. Emerging evidence suggests that EPO may exert anti-inflammatory and metabolic effects beyond its hematopoietic role. This study aimed to compare serum EPO levels and inflammatory biomarkers in CKD patients treated with EPO versus untreated CKD controls.
Material and Methods: This cross-sectional analytical study was conducted on 60 adult patients with CKD undergoing regular hemodialysis. Participants were divided into two …

Current Advances In Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, And Future Perspectives, Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Cancer immunotherapy has emerged as a transformative therapeutic strategy that harnesses the host immune system to recognize and eliminate malignant cells. This review provides a comprehensive overview of current immunotherapeutic approaches, including immune checkpoint inhibitors (ICIs), monoclonal antibodies (mAbs), cancer vaccines, dendritic cell (DC)-based vaccines, chimeric antigen receptor (CAR)-T cell therapy, and oncolytic virus therapy. The mechanisms of action, therapeutic applications, and clinical benefits of each modality are discussed. Monoclonal antibodies selectively target tumor-associated antigens, whereas ICIs restore antitumor immunity by blocking inhibitory immune checkpoints. Cancer vaccines and DC-based vaccines enhance antigen-specific immune responses, while CAR-T cell therapy employs genetically …

Computational Design, Molecular Docking, Sar, And Admet Analysis Of Novel Jak1 Inhibitors As A Possible Treatment For Rheumatoid Arthritis, Sarah Ahmed Waheed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Rheumatoid arthritis is an inflammatory autoimmune disease affecting the joints which eventually leads to systemic comorbidities. Its pathogenesis was attributed to disturbances in the Janus Kinase/Signal Transducer and Activator of Transcription signaling pathway. In this research, an innovative lead compound C6 was created and docked toward Janus Kinase1 (JAK1). The docking process was confirmed by re-docking of the co-crystallized ligand MI1 (Tofacitinib). C6 showed a predicted docking score of -9.17 kcal/mol, with enhancement of 1.26 kcal/mol over Tofacitinib. Evaluation of the interactions showed a framework of five hydrogen bonds within the binding site involving an important contact with Glu966 as …

Diagnostic Accuracy Of Quantitative Coronary Analysis As Compared With Instantaneous Wave-Free Ratio In Intermediate Coronary Lesions: A Prospective Vessel-Level Study, Tamer Mosaad Ragab, Khaled Ahmed Alkhashab, Mohamed Zaki Hussain, Ibrahim Mohammed Nosseir, Marwa Salah Sayed, Waleed Khaled Ali Salem

Journal of the Saudi Heart Association

Background: Instantaneous wave-free ratio (IFR) represents a new vasodilator-free innovative approach which is considered as a gold standard for functional assessment of the hemodynamic significance of intermediate coronary stenoses. Although relatively safe, iFR is still an invasive procedure that has its potential hazards, complications and cost. Two-dimensional quantitative coronary analysis (2D-QCA) is a non-invasive technique that has emerged robustly as an excellent and attractive tool for delineating coronary anatomy.

Aims: To assess the ability of two-dimensional quantitative coronary analysis (2D-QCA) to guide decision-making for quantification of severity of intermediate coronary stenoses (40–80% diameter stenosis) in each of the three main …

Cvgtc‑3.1: A Unified, Place‑And‑Route‑Independent Power‑Grid Research Engine For Early Voltage‑Drop, Dynamic Droop, Electromigration, And Thermal‑Coupled Analysis, Michael Victor Caldwell Mr.

Defensive Publications Series

This disclosure describes CVGTC‑3.1, a fully buildable and testable open‑hardware research engine for early power‑grid analysis in system‑on‑chip (SoC) design. The system integrates:

• A place‑and‑route‑independent DC IR‑drop solver

• A dynamic RLC droop simulator

• An electromigration lifetime estimator

• A machine‑learning IR‑prediction model

• A physical PDN coupon for hardware validation

• A multi‑domain thermal stack including:

• Arachne Microfluidic Interposer (microfluidic cooling + CTE control)

• Vortex‑TPMS Core (high‑flux thermal removal)

• Forgecell PCM Module (transient heat buffering)

• CRFG Thermoacoustic Pump (thermal stabilization)

• MMRA Resonant Diagnostics (EM/IR hotspot detection)

• APR‑AI telemetry for automated calibration and control

• Mechanic’s Battery for stable DC supply during testing

The solver …

Octvec-Xd: Deterministic Multi-Resolution Integer Signatures For Multidimensional Vectors, Nenad Micic

Defensive Publications Series

A technique is proposed herein for converting a multivariate integer vector into a deterministic, fixed-size, multi-resolution signature that separates sign pattern, magnitude scale, quantization frame, and coarse-to-fine direction. Exact integer quantization, bounded portable arithmetic, nested resolution fields, and versioned records provide reproducible results across heterogeneous platforms without floating-point arithmetic, training, dynamic allocation, or per-stream model state. Under a common pinned frame and the declared lossless coarse capacity, participating devices or streams can be correlated by exact tuple equality, while a graded comparison ladder supports finer similarity evaluation. The technique explicitly identifies capacity limits, collision regimes, frame-compatibility requirements, reverse quantization bounds, …

Caldwell Chip‑Scale Vortex‑Tpms Thermal Engine (Ccvte‑3.X) Open‑Hardware • No Patents • No Secrets • Builder‑Ready, Michael Victor Caldwell Mr.

Defensive Publications Series

CCVTE‑3.x is an upgraded chip‑scale thermal engine integrating micro‑vortex conditioning, Diamond/I‑WP TPMS hotspot suppression, graded Diamond→Gyroid transitions, micro‑restrictor flow balancing, and micro‑bypass hydraulic stabilization. It is designed for direct‑die cooling, chiplet cooling, microfluidics, and semiconductor hotspot management.

This invention incorporates improvements derived from prior Caldwell inventions including UGCRM‑2.0, Mechanic’s Battery v3.0, GCI #259‑B, Arachne v9.0, and CVGTC‑2.x. All geometry is scaled to chip‑level dimensions and is fully manufacturable using CNC micromachining, micro‑EDM, or SLM metal printing.

CCVTE‑3.x provides measurable improvements in hotspot suppression, thermal resistance, pump efficiency, boundary‑layer disruption, and transient thermal stability.

Caldwell Variable‑Topology Vortex‑Gyroid Thermal‑Hydraulic Core (Cvgtc‑2.X) Unified Tdcommons Posting + Integration Map + Fabrication Blueprint + Test‑Bench Layout Open‑Hardware • No Patents • No Secrets • Fully Engineer‑Ready, Michael Victor Caldwell Mr.

Defensive Publications Series

CVGTC‑2.x is a next‑generation open‑hardware cold‑plate architecture designed for high‑power electronics, AI accelerators, HPC processors, and advanced thermal research. It integrates:

• heat‑flux‑matched flow allocation

• impedance‑matched manifolds

• variable‑topology TPMS zones

• graded Diamond→Gyroid transitions

• vortex boundary‑layer conditioning

• bypass‑protected hydraulic architecture

• Arachne v9.0 structural + sensing envelope

• optional CRFG‑2.0 transient gradient injection

• optional downstream TEG energy recovery

This document provides:

• TDCommons‑ready disclosure

• Integration map of all six upgraded inventions

• Full fabrication blueprint with hard dimensions and tolerances

• Complete test‑bench wiring + sensor layout

Everything required to build and validate CVGTC‑2.x is included.

Theta-Xd: Integer-Only Direction Change And Slow-Drift Detection In Multivariate Telemetry Streams, Nenad Micic

Defensive Publications Series

A system is proposed herein for detecting sudden turns, changes in turning behavior, and slow drift in the joint movement of multivariate telemetry counters. The system uses an overflow-bounded integer direction metric and an exact division-free threshold gate, requires work linear in the number of counters and fixed-size per-stream state, and produces exactly reproducible results without floating-point arithmetic or model training. Optional discrete direction keys support compact grouping, and peer-relative integer classification identifies outliers among comparable elements. The resulting signals can be generated close to the telemetry source, where independent per-counter thresholds may miss coordinated changes.

Caldwell Multi‑Core Thermal‑Hydraulic Upgrade Suite (2026 Edition) Ugcrm‑2.0 • Cmhre‑Ω2.0 • Mechanic’S Battery V3.0 • Arachne V9.0 • Gci #259‑B • Crfg‑2.0, Michael Victor Caldwell Mr.

Defensive Publications Series

This disclosure presents six upgraded, non‑duplicate open‑hardware inventions that collectively enhance the performance of the Caldwell Variable‑Topology Vortex‑Gyroid Thermal‑Hydraulic Core (CVGTC‑2.x). Each subsystem is independently buildable and testable, and each contributes measurable improvements in heat‑transfer density, hydraulic efficiency, sensing fidelity, vortex conditioning, and transient thermal‑gradient control.

The suite includes:

• UGCRM‑2.0 — Variable‑Topology TPMS Thermal Distribution Engine

• CMHRE‑Ω2.0 — Heat‑Flux‑Matched Thermal Validation Platform

• Mechanic’s Battery v3.0 — TPMS‑Aware Low‑ΔP Branching Engine

• Arachne v9.0 — Structural + Sensing + Leak‑Detection Backbone

• GCI #259‑B — Chip‑Scale Vortex Conditioner

• CRFG‑2.0 — COP‑Gated Thermoacoustic Gradient Engine

All inventions are compatible with CVGTC‑2.x and increase its …

Single-Queue, Multi-Kind Escalation: One Human-Confirmation Gate For Three Structurally Different Automated Judgments In An Autonomous Compliance Pipeline, Vipul Panday

Defensive Publications Series

An autonomous pipeline that both detects issues and acts on them (filing tickets, refreshing a reference corpus, adopting a new rule) will, almost as soon as it does more than one kind of consequential thing, produce more than one kind of moment where its own judgment is not trustworthy enough to act on unsupervised. The conventional response is a bespoke review mechanism per kind of uncertainty, added piecemeal as each is discovered during development: a findings-review screen here, an admin flag there, a Slack thread for whatever comes up next. This disclosure documents a mechanism from a production website-accessibility scanning …

Tamper-Proof Artificial Intelligence (Ai) Decision Chains, Raghunath Ramesh Kulkarni, Jaswanth D K, Pranetha Priya R

Defensive Publications Series

Autonomous artificial intelligence (AI) agents increasingly perform critical tasks, yet their lack of transparency makes it difficult to verify that a model was authentic and uncompromised when a decision was made and to maintain a trustworthy audit trail. The techniques presented herein implement a Cryptographic Agent Provenance Ledger (CAPL) security architecture that uses hardware-backed enclaves, privacy-preserving zero-knowledge proofs, hardware-rooted state continuity, and in-enclave cryptographic batching to create tamper-resistant, forensic-grade provenance for AI decisions. CAPL gates release of each inference output until its provenance record is created and ordered, while later hardware-backed notarization anchors batches of already-gated records. By cryptographically binding …

Method For Memory-Bounded Construction Of A Globally Complete, High-Zoom-Level Cloud-Optimized Geotiff From Tile-Access Logs, Sascha Brawer

Defensive Publications Series

A memory-bounded method is disclosed for constructing a globally complete, high-zoom-level Cloud-Optimized GeoTIFF — a planet-wide raster at web-map zoom level 18, on the order of 10¹¹ cells — from a rolling window of tile-access logs, using working memory that is essentially constant in the number of cells. The output is a standards-compliant COG with a full reduced-resolution overview pyramid, derived by robustly aggregating the per-tile time series; it is several hundred times smaller than a naïve dense encoding. The method combines a level-embedding space-filling tile key, a two-stage disk-backed ordering (per-period external sort followed by a cross-period streaming merge), …

System And Method For Provenance-Gated Vector Embedding: Structural Exclusion Of Shadow Inference Records From Production Ai Knowledge Bases, Durga S. Kala, Tianyi Xu, Ketaki Surendra Kumbharkar, Jun Xu

Defensive Publications Series

The present disclosure relates to a method and a system for maintaining provenance-based separation of Artificial Intelligence (AI) inference data. The present disclosure suggests receiving an inference result record generated by an artificial intelligence (AI) inference platform. The present disclosure also suggests identifying a provenance attribute associated with the inference result record, the provenance attribute indicating an execution context of the artificial intelligence model. Based on the provenance attribute, the present disclosure suggests determining whether the inference result record corresponds to a production execution mode, a shadow execution mode, or an unrecognized execution mode. Upon determination, the present disclosure suggests …

A Process For The Preparation Of Elafibranor And Its Intermediate, Msn Laboratories Private Limited, R&D Center; Srinivasan Thirumalai Rajan, Sagyam Rajeshwar Reddy, Keshavareddy Navin Kumar Reddy And Kootikanti Krishnaiah.

Defensive Publications Series

The present disclosure relates to a novel process for the preparation of Elafibranor and its novel intermediate. The structure of Elafibranor of formula-1 is shown below:

Formula-1.

The present application also provides a crystalline form of Elafibranor and its process for the preparation.

Designing High-Resilience Hybrid Metamaterials: A Systems Engineering Specification For Elemental Hybridization, Solitonic Stabilization, And Non-Destructive Process Verification In Artificial Crystal Lattices, Christopher L. Eckes

Defensive Publications Series

Traditional artificial crystal lattices grown via high-mass commercial methods exhibit acute failure modes under extreme operational environments. These loops manifest as high-frequency acoustic micro-cracking along crystal grain boundaries during cyclic load profiles, or structural delamination driven by thermal expansion differentials across thin-film interfaces.

This specification introduces a formalized systems engineering framework for the elemental hybridization of lab-grown crystal substrates—specifically Thin-Film Lithium Niobate (LiNbO₃) and 3D Self-Assembled Inverse Opal Lattices. By strategically infiltrating these substrates with low-weight-fraction Graphene Oxide (GO) nanosheets and Boron Nitride Nano-Tubes (BNNTs), we create hybrid, non-linear metamaterials that isolate, dampen, and redirect destructive kinetic and thermal wave …

Electrospun Pvp/Zno/Ha Coatings On Silane-Modified Zk60: Corrosion, Antibacterial Activity, And In Vitro Apatite Formation, Qasim Saad Abdulwahid, Akeel Dhahir Subhi, Iman Adnan Annon

Engineering and Technology Journal

This study investigated a two-stage surface modification strategy for ZK60 magnesium alloy based on 3-aminopropyltriethoxysilane (APTES) pretreatment followed by electrospun polyvinylpyrrolidone (PVP) nanofibers containing ZnO and hydroxyapatite (HA) nanoparticles. Three PVP/ZnO/HA formulations were prepared to examine the effect of nanoparticle loading, and corresponding coatings with and without APTES pretreatment were compared. The coatings were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM/EDX), and a cross-hatch adhesion test. Corrosion behavior was evaluated in simulated body fluid (SBF) using open-circuit potential (OCP) monitoring and potentiodynamic polarization. Antibacterial activity was screened against S. …

Corrosion Inhibition By Carboxymethyl Cellulose Doped With Graphite Nanosheet And Silica Nanoparticles In Seawater Environment, Mohamed R. Mohssen, Sinan S. Hamdi, Rana A. Anaee, Mathew T. Mathew

Engineering and Technology Journal

This work aims to inhibit carbon steel surface as pipelines by adding carboxymethyl cellulose (CMC) with three concentrations (1, 3 and 5 g/L) in seawater environment at four temperatures in the range of 298 – 328 K. The investigation was done by recording Tafel plots and EIS curves to show that the lowest concentration is the best to protect the steel surface with efficiencies ranged between 95.68 – 89.36 % that decrease with increasing temperature due to the decomposition of CMC that begin after ≈ 308 K. An attempt to enhance the protection by CMC at higher temperature has been …

Reconfiguring Distribution Networks Using The Aco+Tnc Algorithm, Specifying The Location, Size, And Number Of Added Renewable Energy Sources, Mohammed Falah Hasan, Rana Ali Abttan

Engineering and Technology Journal

Distribution networks face increasing pressure from rising loads and renewable energy integration, making the simultaneous optimization of reconfiguration and distributed generation placement a critical engineering challenge, and conventional single-objective methods are insufficient for simultaneously addressing power losses, voltage profile degradation, and the structural constraints of radial networks. This paper proposes a hybrid framework that combines Ant Colony Optimization with the Truncated Newton Constrained method to jointly solve network reconfiguration alongside the optimal placement, sizing, and type selection of renewable distributed generation—both solar PV and wind—within a single unified model. The approach relies on a four-part weighted objective function covering active …

Illinois Wesleyan University Celebrates Grand Opening Of Petrick Idea Center, Emily Bollinger

Press Releases 2020-2029

No abstract provided.

Montana Kaimin, September 3, 2026, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Building Better Research: Structured Activities To Support Student Projects, Alicia G. Vaandering

Faculty Learning Day 2026

Students often feel overwhelmed by large research assignments, struggling to break large papers, presentations, or other projects into manageable steps. This session explores practical ways to support the development of students’ research skills through scaffolded in-class activities and assignments. Participants will leave with adaptable ideas for designing and implementing sequenced tasks that reduce overwhelm while building critical research and information literacy skills.

Tips & Tricks For Fostering Online Engagement, Jacqueline Kociubuk, Karen Haskell, Arthur J. Spivack

Faculty Learning Day 2026

Creating engagement in online classroom spaces often requires new or unique tools, strategies, and practices. Join us as we share some of our student-tested methods for building online engagement in undergraduate and graduate courses across the humanities, social sciences, and natural sciences.

Appeal No.1067: Arrowhead Road Services, Llc V. Division Of Oil & Gas Resources Management, Ohio Oil & Gas Commission

Ohio Oil & Gas Commission Decisions

Review of Chief's Orders 2025-512

Complementary Vertebrate Wac Models Exhibit Phenotypes Relevant To Desanto-Shinawi Syndrome, Kang-Han Lee, Marwan Shinawi, Et Al.

2020-Current year OA Pubs

Monogenic syndromes are associated with neurodevelopmental changes that result in cognitive impairments and neurobehavioral phenotypes, including autism and seizures. Limited studies and resources are available to make meaningful headway into the underlying molecular mechanisms that result in these symptoms. One such example is DeSanto-Shinawi Syndrome (DESSH), a rare disorder caused by pathogenic variants in the

Fast Discovery Of Motivic Patterns In Symbolic Music Via Lossy Compression, Adam James Wilson

Publications and Research

Generative systems that react to live musicians require rapid analysis of musical data, which rules out deep learning models: they cannot be trained within the time constraints of live performance. But because analysis results are often transformed before use, we are free to reduce the parameters that undergo transformation to a small set of primitive states. We address this coincidence of constraint and opportunity with an algorithm for online discovery of maximal musical motives that achieves speed through lossy compression: the pitch and inter-onset-interval deltas for all pairs of events in a potential motive are reduced to two-bit values, conceptualized …