Digital Commons Network^™

Crystalline Forms Of 3-[3-(3,5-Dimethyl-1h-Pyrazol-4-Yl) Propoxy]-4-Fluorobenzoic Acid And Its Use In The Pharmaceutical Compositions, Msn Laboratories Private Limited, R&D Center, Srinivasan Thirumalai Rajan, Sagyam Rajeshwar Reddy, Revu Satyanarayana, Kommera Rajasekhar, Keshavareddy Navin Kumar Reddy, Parigi Raghavendar Reddy, Garai Abhijit, Yata Murali, Mayandi Ramesh

Defensive Publications Series

Abstract:

The present disclosure relates to a crystalline forms of 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid and process for their preparation.

Further, the present disclosure provides a pharmaceutical composition comprising Acoramidis or a pharmaceutically acceptable salt thereof.

The structure of Acoramidis is shown as below formula 1.

Formula-1

Caldwell Global Thermodynamic Upgrade Engine — Gaps 21–30 Edition, Michael Victor Caldwell Mr.

Defensive Publications Series

Global analyses from the UN, WHO, IPCC, FAO, IEEE, and OECD identify ten critical gaps beyond the first 20 worldwide thermodynamic gaps: heat‑resilient agriculture, soil heavy‑metal remediation, atmospheric pathogen capture, emergency medical shelter stability, hydrogen micro‑production safety, battery‑storage cooling, water‑positive mining, refugee‑infrastructure stability, waste‑heat‑to‑water conversion, and micro‑reactor safety.

This disclosure presents a unified thermodynamic upgrade engine designed to fill all ten gaps using gyroid thermal‑hydraulic cores, TPMS purification lattices, vortex‑enhanced cooling engines, atmospheric water harvesters, MOF‑gyroid remediation cartridges, quantum‑grade cold‑plates, micro‑thermal biologic reactors, and chemical‑neutralization lattices.

Includes full architecture, subsystem breakdown, BOM, build path, test protocol, physics rationale, performance analysis, …

Caldwell Global Thermodynamic Upgrade Engine — Gaps 11–20 Edition, Michael Victor Caldwell Mr.

Defensive Publications Series

Global priority analyses from the UN, WHO, IPCC, OECD, and IEEE identify ten critical gaps beyond the WEF Top‑10 list: water purification, atmospheric carbon capture, heat‑resilient medical supply chains, extreme‑heat urban cooling, environmental physics sensing, quantum‑thermal stability, food‑security bioprocessing, off‑grid medical manufacturing, climate‑resilient data centers, and persistent chemical destruction.

This disclosure presents a unified thermodynamic upgrade engine designed to fill all ten gaps using vortex‑TPMS cooling modules, gyroid thermal‑hydraulic cores, atmospheric water harvesters, MOF‑gyroid carbon cartridges, medical thermal‑power engines, environmental physics mappers, quantum cold‑plates, fermentation cores, biologic reactors, and chemical‑destruction lattices.

Includes full architecture, subsystem breakdown, BOM, build path, test …

Caldwell Thermodynamic Upgrade Engine For Wef 2026 Emerging Technologies, Michael Victor Caldwell Mr.

Defensive Publications Series

The World Economic Forum’s Top Emerging Technologies of 2026 identify critical gaps in thermal stability, micro‑structured geometries, environmental sensing, waste‑heat routing, water‑positive operation, and multi‑system coupling. This disclosure presents a unified thermodynamic upgrade engine composed of vortex‑TPMS cooling modules, gyroid thermal‑hydraulic cores, chip‑scale thermal engines, environmental‑state observatories, atmospheric water harvesters, and auxiliary subsystems. Each subsystem is explained in detail, including how it directly fills a WEF gap, how it works, and how it can be built. Includes full architecture, BOM, build path, test protocol, physics rationale, performance analysis, alternate configurations, simulation notes, and a global deployment roadmap. This disclosure is …

Autonomous Cyber Defense Policy Evolution Framework Using Risk-Aware Digital Twin Validation And Explainable Ai Feedback, Amir Hossein Jafari Chashmi

Defensive Publications Series

This disclosure presents a computer-implemented autonomous cyber-defense framework for generating, validating, deploying, monitoring, and evolving cybersecurity policies. The framework treats a security policy as an evolving control object and combines continuous security and operational telemetry, risk-aware analysis, generation of multiple candidate policy changes, machine-readable digital-twin validation, constrained candidate evaluation, explainable decision recording, controlled deployment, post-deployment monitoring, automatic rollback, and feedback-driven policy evolution. Candidate policies are evaluated before operational deployment against modeled security and operational conditions, including threat reduction, reachability, availability, latency, resource impact, policy conflicts, scope integrity, confidence, and recovery readiness. A decision controller may approve, modify, reject, defer, or …

Caldwell Quantum‑Safe Zero‑Knowledge Authentication Engine (Zk‑Nexus‑1.0), Michael Victor Caldwell Mr.

Defensive Publications Series

This invention provides a quantum‑safe zero‑knowledge authentication engine designed for networks that must verify identity without revealing credentials. ZK‑NEXUS‑1.0 integrates multi‑domain entropy fusion, resonance‑stabilized randomness, temporal‑artifact removal, lattice‑based zero‑knowledge proofs, and noise‑aligned challenge‑response protocols. The system improves authentication stability, eliminates credential exposure, and enhances resistance to quantum‑accelerated attacks. The core physics principle is that multi‑modal entropy fusion and resonance‑aligned randomness produce high‑stability zero‑knowledge proofs that remain secure against quantum adversaries. This disclosure includes full architecture, BOM, build path, and test protocol. This work is intended as open‑hardware prior art to ensure global public access.

Caldwell Quantum‑Safe Resonance‑Stabilized Cryptographic Key‑Exchange Engine (Qs‑Nexus‑1.0), Michael Victor Caldwell Mr.

Defensive Publications Series

This invention provides a next‑generation quantum‑safe cryptographic key‑exchange engine designed for hybrid networks that must remain secure against classical and quantum attacks. QS‑NEXUS‑1.0 integrates multi‑modal entropy harvesting, resonance‑stabilized randomness, temporal‑artifact removal, hybrid lattice‑based key encapsulation, and adaptive noise‑aligned packetization. The system improves key‑exchange stability, reduces entropy loss, and enhances resistance to quantum decryption. The core physics principle is that multi‑domain entropy fusion and resonance‑aligned randomness produce high‑stability keys that resist quantum‑accelerated attacks. This disclosure includes full architecture, BOM, build path, and test protocol. This work is intended as open‑hardware prior art to ensure global public access.

Caldwell Multi‑Modal Federated‑Learning Engine With Differential Privacy & Resonance‑Stabilized Aggregation (Fl‑Nexus‑2.0), Michael Victor Caldwell Mr.

Defensive Publications Series

This invention provides a next‑generation federated‑learning engine for edge devices requiring privacy‑preserving model training without transmitting raw data. The system integrates multi‑modal sensor fusion, temporal‑artifact removal, adaptive gradient compression, differential‑privacy noise shaping, and resonance‑stabilized aggregation to improve accuracy, reduce bandwidth, and enhance privacy. The core architecture uses stabilized multi‑domain tensors and artifact‑cleaned gradients to ensure reliable convergence across heterogeneous devices. The key physics principle is that multi‑modal fusion and resonance‑aligned aggregation reduce drift and noise during distributed learning. This disclosure includes full architecture, BOM, build path, and test protocol. This work is intended as open‑hardware prior art to ensure global …

Uaif‑2.0: Vendor‑Neutral Ai‑To‑Physical‑Safety Contract And Deterministic Enforcement Interface For Cyber‑Physical Systems, Michael Victor Caldwell Mr.

Defensive Publications Series

UAIF‑2.0 defines a vendor‑neutral, machine‑readable safety contract and deterministic enforcement interface connecting AI agent governance systems to independently assured physical‑safety controllers. Existing AI governance layers authorize actions; existing functional‑safety systems enforce physical constraints. No broadly adopted, vendor‑neutral standard currently defines how authorized AI actions should be translated into bounded physical‑domain constraints consumable by a safety‑rated controller.

UAIF‑2.0 introduces a Safety Contract and a Safety Envelope Compiler. The contract binds AI identity, capability, authorization window, physical constraints, safety envelope, provenance, and revocation status into a deterministic, cryptographically verifiable document. The compiler transforms human‑authored safety rules and engineering constraints into a monotonic, …

Caldwell Multi‑Modal Application‑Profile Network Routing Engine (Map‑Nre‑1.0), Michael Victor Caldwell Mr.

Defensive Publications Series

This invention provides a multi‑modal network‑quality measurement and routing engine designed to classify and route application traffic based on realistic, application‑specific performance metrics rather than high‑priority control packets. The system measures loss, latency, and jitter using traffic profiles that match actual application behavior, enabling routing decisions that reflect true network conditions. The core architecture integrates distributed measurement nodes, temporal‑artifact inspection, multi‑modal signal profiling, and adaptive routing logic. The key principle is that network liveliness must be measured using representative traffic rather than artificially prioritized packets. This disclosure includes full architecture, BOM, build path, and test protocol. This work is intended …

Multi-Channel Orchestration Of Context-Aware User Feedback Collection, Parnika Singhal

Defensive Publications Series

Collecting user satisfaction data can be challenging, as certain methods, such as delayed, single-channel email surveys, may result in low participation and skewed datasets. Disclosed are systems and methods for a multi-channel, event-driven orchestration framework for soliciting user feedback. A system can be initiated by an event, for example a support case closure, and may send an initial notification directing a user to a survey. For users who do not respond, a conditional, context-aware reminder can be delivered through an alternative communication channel, such as a synchronous chat application, after considering factors like the user's local time and calendar availability. …

Decentralized Contextual Personalization Using An On-Device Personal Knowledge Graph, N/A

Defensive Publications Series

Conventional personalization systems that utilize centralized, server-side user data collection may present privacy challenges and can result in profile contamination from transient user intents. A decentralized, client-side framework can shift data storage and processing to a user's local computing device (e.g., a smartphone, smart watch, wearable device, etc.). This framework can utilize a private, on-device knowledge graph to manage user context. For a given user action, a client-side process can extract a relevant sub-graph of contextual data, convert it into a transient, privacy-enhanced vector, and transmit it to a remote service. The service may return a generalized set of results …

Natural Language Query Decomposition Using A Small Language Model With Parallel Schema Processing, Pinkesh Badjatiya

Defensive Publications Series

Conversational artificial intelligence systems for enterprise databases may face a trade-off between the potentially high cost and latency of large models and the potentially lower accuracy of smaller models when processing complex, domain-specific schemas. A system is described for natural language query decomposition that can use a constrained-parameter small language model (SLM). The system can process large data schemas by decomposing them into smaller, parallel batches. Specialized prompt engineering, such as an inverted prompt structure for caching, and a structured reasoning template can guide the SLM. A sequential ambiguity resolver may then consolidate outputs from the parallel workers into a …

Caldwell Thermodynamic Upgrade Engine For Global Gaps 91–100, Michael Victor Caldwell Mr.

Defensive Publications Series

Global infrastructure analyses identify ten critical thermodynamic gaps beyond the first 90 worldwide gaps: humanitarian thermal‑stable blood‑transport nodes, micro‑structured cooling for magma‑adjacent industrial tunnels, atmospheric fluorine‑residue capture, thermal‑stable anaerobic‑digestion reactors, agricultural root‑zone cooling, extreme‑heat seaport‑signal stability, micro‑structured neutralization of industrial perchlorates, thermal‑stable emergency‑evacuation command hubs, water‑positive cooling for border‑region veterinary‑inspection nodes, and micro‑structured cooling for high‑density quantum‑sensor manufacturing.

This disclosure presents a unified thermodynamic upgrade engine composed of gyroid thermal‑hydraulic cores, TPMS purification lattices, vortex‑TPMS cooling modules, atmospheric water harvesters, micro‑particle capture lattices, chip‑scale cooling engines, radiative gyroid condensers, and auxiliary subsystems.

Includes full architecture, subsystem breakdown, BOM, build path, …

Secure Payment Payload Relay From An Offline Payer Device To A Connected Merchant Terminal, Saicharan Nimmala, Vineeth Kumar, Piyush Ramuka, Sanket Jain, Sailendra Bathi, Vishal Shroff

Defensive Publications Series

Digital payment transactions fail when a payer's computing device lacks an active internet connection, which can cause transaction failures in areas with poor network coverage. This disclosure describes systems and methods that address this issue by leveraging a merchant's network connectivity. For example, a payer's offline computing device (e.g., a smartphone, smart watch, or wearable device) can generate a multi-layered, cryptographically secure data payload encapsulating transaction and authorization details. This payload can then be transferred locally, such as via a dynamic quick response (QR) code or near-field communication, to a merchant’s terminal with an active internet connection . The merchant's …

Adaptive Discovery And Policy-Based Routing Of Local And Network Ai Services, Hp Inc

Defensive Publications Series

This article describes a client-side system that discovers artificial-intelligence services available on the same device, on a local network, or through a configured remote connection, and selects a suitable service separately for each request. Selection considers required functions, input sensitivity, response delay, service load, operating cost, network condition, and the client device’s battery and thermal state. A local classifier applies mandatory handling rules before any request leaves the device. Services that fail a functional or data-location constraint are removed; the remaining services are ranked, and ordered alternatives are retained for controlled failover. Conversation state is stored in a service-neutral representation …

Caldwell Thermodynamic Upgrade Engine For Global Gaps 81–90, Michael Victor Caldwell Mr.

Defensive Publications Series

Global infrastructure analyses identify ten critical thermodynamic gaps beyond the first 80 worldwide gaps: humanitarian thermal‑stable vaccine‑transport nodes, micro‑structured cooling for volcanic‑adjacent operations, atmospheric chlorine‑residue capture, thermal‑stable compost‑gas reactors, agricultural micro‑greenhouse cooling, extreme‑heat airport‑signal stability, micro‑structured neutralization of industrial bromates, thermal‑stable emergency‑response coordination centers, water‑positive cooling for border‑region food‑inspection nodes, and micro‑structured cooling for high‑density photonics manufacturing.

This disclosure presents a unified thermodynamic upgrade engine composed of gyroid thermal‑hydraulic cores, TPMS purification lattices, vortex‑TPMS cooling modules, atmospheric water harvesters, micro‑particle capture lattices, chip‑scale cooling engines, radiative gyroid condensers, and auxiliary subsystems.

Includes full architecture, subsystem breakdown, BOM, build path, test …

Process For The Preparation Of Tirzepatide, Anonymous

Defensive Publications Series

Based on literature, present inventors provide a process for the preparation of Tirzepatide.

Maturity-Adaptive Dynamic Ai Prompt Generation Using Network-Grounded Context Bundles, Mitchell Villeneuve, Pavan Bykampadi, Katie Louise Nail

Defensive Publications Series

A system is described herein for adapting artificial intelligence (AI) assistant landing-page prompts to individual user maturity. A persisted behavioral profile establishes an explorer, practitioner, or power-user stage that controls visible suggestion categories and dynamic-generation eligibility. Before the user submits a query, a coordinator assembles a context bundle from user query history, organization-level intent signals, role-based access control (RBAC) scope, and live network alerts or configuration changes. A large language model (LLM) generates up to five grounded suggestions, which are schema-validated and deterministically filtered for authorization before delivery. Refresh heuristics, context-fingerprint deduplication, per-user concurrency control, and honest empty results bound …

Method For Secure, Least-Privilege Local Execution Of Cloud-Hosted Artificial Intelligence Operations On Day-Zero And Network-Isolated Devices Via A Hardened Endpoint Bridge, Marian Volodymyrovych Rydzanych, Goudam Jaganmohan Muralitharan

Defensive Publications Series

A system is described herein for enabling a cloud-hosted artificial intelligence (AI) agent to securely execute a small, explicitly governed, fully audited set of local actions on an operator workstation. A hardened desktop bridge turns the workstation into a trusted proxy that extends the agent to day-zero, greenfield, and network-isolated devices through serial, Universal Serial Bus (USB), and local area network (LAN) paths during initial bring-up. Least privilege is maintained through a sandboxed renderer, a narrow inter-process boundary, a runtime fail-safe command allowlist, operating system (OS) keychain credential isolation, unconditional shell-metacharacter blocking, and an append-only audit log. The agent can …

Caldwell Thermodynamic Upgrade Engine For Global Gaps 71–80, Michael Victor Caldwell Mr.

Defensive Publications Series

Global infrastructure analyses identify ten critical thermodynamic gaps beyond the first 70 worldwide gaps: humanitarian cold‑chain stabilization, geothermal‑adjacent micro‑cooling, atmospheric sulfur‑residue capture, thermal‑stable landfill‑gas processing, agricultural nutrient‑solution cooling, extreme‑heat rail‑signal stability, micro‑structured neutralization of industrial chlorates, thermal‑stable emergency logistics hubs, water‑positive cooling for border‑region medical triage, and micro‑structured cooling for high‑density semiconductor packaging.

This disclosure presents a unified thermodynamic upgrade engine composed of gyroid thermal‑hydraulic cores, TPMS purification lattices, vortex‑TPMS cooling modules, atmospheric water harvesters, micro‑particle capture lattices, chip‑scale cooling engines, radiative gyroid condensers, and auxiliary subsystems.

Includes full architecture, subsystem breakdown, BOM, build path, test protocol, physics rationale, performance …

Caldwell Thermodynamic Upgrade Engine For Global Gaps 61–70, Michael Victor Caldwell Mr.

Defensive Publications Series

Global infrastructure analyses identify ten critical thermodynamic gaps beyond the first 60 worldwide gaps: thermal‑stable humanitarian refrigeration, micro‑structured cooling for geothermal operations, atmospheric ammonia‑residue capture, thermal‑stable wastewater treatment nodes, agricultural seed‑storage cooling, extreme‑heat telecom tower stability, micro‑structured neutralization of industrial nitrates, thermal‑stable emergency robotics hubs, water‑positive cooling for border‑region checkpoints, and micro‑structured cooling for high‑density manufacturing robotics.

This disclosure presents a unified thermodynamic upgrade engine composed of gyroid thermal‑hydraulic cores, TPMS purification lattices, vortex‑TPMS cooling modules, atmospheric water harvesters, micro‑particle capture lattices, chip‑scale cooling engines, radiative gyroid condensers, and auxiliary subsystems.

Each subsystem is explained in detail, including how it …

Caldwell Thermodynamic Upgrade Engine For Global Gaps 51–60, Michael Victor Caldwell Mr.

Defensive Publications Series

Global infrastructure analyses identify ten critical thermodynamic gaps beyond the first 50 worldwide gaps: humanitarian water‑transport stability, solar‑farm cooling, atmospheric chemical‑residue capture, waste‑sorting thermal stability, agricultural robotics cooling, desert transportation hub cooling, industrial VOC neutralization, emergency power node cooling, mining robotics cooling, and public‑health station cooling.

This disclosure presents a unified thermodynamic upgrade engine composed of gyroid thermal‑hydraulic cores, TPMS purification lattices, vortex‑TPMS cooling modules, atmospheric water harvesters, micro‑particle capture lattices, chip‑scale cooling engines, radiative gyroid condensers, and auxiliary subsystems.

Each subsystem is explained in detail, including how it directly fills a global gap, how it works, and how it …

Integrated System And Experimental Study Of A Compact Electro-Hydraulic Actuator For Marine Applications, Jiangang Yan

Yanbu Journal of Engineering and Science

To address issues such as loose structure, low integration, and reliance on imports in existing marine electro-hydraulic actuators, this paper presents an integrated compact electro-hydraulic actuation device. The device integrates the drive unit, connection block, hydraulic actuation unit, and feedback signal box into one assembly. Through the integrated design of a built-in radial piston pump and valve block, a micro hydraulic power unit with no external pipelines is achieved. This paper elaborates on the structural composition, working principle, and key module design of the device, and analyzes the implementation of its triple redundancy operation modes: "electric - manual hydraulic - …

Saudi Coffee And Representations Of National Identity: A Comparative Study Of Nabati Poetry And Travelogues, Bader I. Al-Harbi, Ahmad Ahmad Abd Al-Maqsoud Abd Al-Aal

Scientific Journal of King Faisal University: Humanities and Management Sciences

This study examines Saudi coffee as a symbol of national identity in the discourses of Western and Arab travelers and Saudi Nabati poets. Using comparative cultural criticism, it analyzes the emotions, collective images, and cultural meanings associated with coffee across these differing discourses. The findings identify three patterns of cultural representation: an ethnographic pattern in Western travel discourse that documents and defines the “exotic” other; a renaissance- oriented (nahḍawi) pattern in Arab travel discourse that presents coffee as a symbol of Arab national identity and views the Saudi state as a source of hope for unity and renaissance; and a …

Book Review: The History And Politics Of Star Wars: Death Stars And Democracy, Petra Hendrickson

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Book Review: The History and Politics of Star Wars: Death Stars and Democracy

Gc-Ms Profiling And Antibacterial Activity Of Cold-Macerated Garlic Extracts Against Multidrug-Resistant Uropathogens, Fatima A. Khalaf, Saeed A. Fayadh

Karbala International Journal of Modern Science

The growing number of cases of multidrug-resistant (MDR) urinary tract infections has made the clinical management of urinary tract diseases a significant challenge; therefore, the need for effective adjunctive therapies cannot be overemphasized. This study evaluated the bioactive components and antibacterial efficacy of cold-macerated garlic extracts obtained using distilled water, 70% ethanol and hexane solvents against antimicrobial-resistant urinary isolates. Out of 250 urine samples that were analyzed, 124 (49.6%) showed significant microbial growth, with Escherichia coli being the most frequently isolated organism. The results of the phytochemical screening and Gas Chromatography-Mass Spectrometry (GC-MS) analysis showed that the ethanolic extract had …

Reconstructing The Enforcement Of The Code Of Ethics For General Elections In Indonesia: A Prophetic Law Perspective, Fradhana Putra Disantara, Ratih Listyana Chandra, Aan Efendi, Iwan Rachmad Soetijono, Souad Ahmed Ezzerouali

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

This research examines the reconstruction of ethical code enforcement for election organizers in Indonesia through the perspective of prophetic law, arguing that ethical adjudication should extend beyond procedural compliance by integrating humanization, liberation, and transcendence as normative foundations of substantive justice. Employing doctrinal legal research, the study uses statutory, conceptual, case, and comparative approaches. It compares Indonesia's regulatory framework with the ethical governance systems of India and the United States to identify institutional models that strengthen integrity while respecting distinct constitutional traditions. The findings demonstrate that ethical adjudication differs fundamentally from administrative law: it governs the forum internum of election …

Caldwell Thermodynamic Upgrade Engine For Global Gaps 41–50, Michael Victor Caldwell Mr.

Defensive Publications Series

Global infrastructure analyses identify ten critical thermodynamic gaps beyond the first 40 worldwide gaps: global food cold‑chain stability, EV fast‑charging cooling, atmospheric micro‑plastic capture, water‑distribution thermal stability, autonomous‑vehicle compute cooling, emergency drone cooling, remote medical‑clinic cooling, agricultural‑chemical neutralization, rural edge‑compute cooling, and robotics cooling in extreme environments.

This disclosure presents a unified thermodynamic upgrade engine composed of gyroid thermal‑hydraulic cores, TPMS purification lattices, vortex‑TPMS cooling modules, atmospheric water harvesters, micro‑particle capture lattices, chip‑scale cooling engines, radiative gyroid condensers, and auxiliary subsystems.

Each subsystem is explained in detail, including how it directly fills a global gap, how it works, and how …

Caldwell Thermodynamic Upgrade Engine For Global Gaps 31–40, Michael Victor Caldwell Mr.

Defensive Publications Series

Global infrastructure analyses identify ten critical thermodynamic gaps beyond the first 30 worldwide gaps: vertical‑farm cooling, micro‑structured desalination, thermal‑stable vaccine manufacturing, atmospheric micro‑particle capture, humanitarian food‑processing stability, satellite ground‑station cooling, remote industrial camp cooling, PFAS‑adjacent soil neutralization, emergency communication node cooling, and AI‑edge device cooling in hot regions.

This disclosure presents a unified thermodynamic upgrade engine composed of gyroid thermal‑hydraulic cores, TPMS purification lattices, vortex‑TPMS cooling modules, atmospheric water harvesters, micro‑particle capture lattices, chip‑scale cooling engines, radiative gyroid condensers, and auxiliary subsystems.

Each subsystem is explained in detail, including how it directly fills a global gap, how it works, and …